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  • AHF Urges Vaccine Equity as Mpox Cases Surge in Sierra Leone – Business Wire

    1. AHF Urges Vaccine Equity as Mpox Cases Surge in Sierra Leone  Business Wire
    2. Multi-country outbreak of mpox, External situation report #54 – 27 June 2025  World Health Organization (WHO)
    3. S2 Ep4: Monkeypox (hMPXV) Update  iHeart
    4. 6,823 Mpox Cases and 16 Fatalities Last Month  Vax-Before-Travel
    5. Op-ed: Fighting an mpox outbreak, Sierra Leone ‘shouldn’t have to stand alone’  Harvard T.H. Chan School of Public Health

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  • Trust in UN’s nuclear watchdog is broken, Iranian president says | Iran’s nuclear programme

    Trust in UN’s nuclear watchdog is broken, Iranian president says | Iran’s nuclear programme

    Trust in the UN nuclear inspectorate is broken inside Iran, the country’s president, Masoud Pezeshkian, has told Emmanuel Macron, as European nations issued a statement in defence of its head.

    The two men spoke as Iranian officials said the total number of Iranian deaths during the 12-day air war with Israel and the US had risen to 935 people, including 38 children and 132 women.

    Pezeshkian criticised Rafael Grossi, the International Atomic Energy Agency (IAEA) director general, in the call, according to an Iranian account, saying he had not condemned the Israeli and US attacks even though they had been in flagrant breach of the UN charter and the nuclear non-proliferation treaty (NPT). His language was more constrained than others in Iran, where the conservative newspaper Kayhan said if Grossi came to the country he should be put on trial and sentenced to death for links to the Israeli spy agency the Mossad.

    The IAEA director general, Rafael Grossi. France, Germany and the UK condemned Iran’s threats against him. Photograph: Elisabeth Mandl/Reuters

    A joint statement on Monday from the UK, France and Germany said they condemned threats against Grossi “and reiterate our full support to the agency and [Grossi] in carrying out their mandate”, calling on Iran to cooperate with it.

    “We call on Iranian authorities to refrain from any steps to cease cooperation with the IAEA. We urge Iran to immediately resume full cooperation in line with its legally binding obligations, and to take all necessary steps to ensure the safety and security of IAEA personnel,” it said.

    But the sense in Iran of western double standards is fuelling a deep feeling of grievance, as well as a refusal to give the IAEA access to make an independent assessment of the damage to Iran’s nuclear sites, leaving such assessments to highly politicised reports emerging from the US.

    According to the Iranian account of the Sunday evening call, Pezeshkian told the French president: “What guarantee is there that our facilities won’t be attacked again, even if we cooperate?” He also questioned why Israel, which is not a member of the NPT, had been allowed to become a source of evidence for IAEA reports.

    Despite persistent reports that Iran and the US are using back channels to set up further indirect talks under the mediation of Oman, Iran’s deputy foreign minister, Majid Takht-Ravanchi, said no such dates or times had been agreed.

    A compromise being floated by the US special envoy Steve Witkoff suggests that Iran be entitled to enrich uranium, a key Iranian demand, but in a consortium on the Iranian island of Kish under severe constraints.

    Speaking at a seminar hosted by the UK defence thinktank the Royal United Services Institute, Nicholas Hopton, a former UK ambassador to Iran, said huge damage had been done to the Iranian regime, but questioned whether any of Israel’s key objectives had been met including regime change. He said: “There was little evidence that Iran was rushing to a bomb three weeks ago and apparently now 400 kilos of highly enriched uranium are unaccounted for.

    “It will be a long time before the IAEA can comment authoritatively on the extent to which Iran’s nuclear programme has even degraded.”

    Ali Ansari, a professor of Iranian history at St Andrews University, said: “There is a lot of shouting about nationalist solidarity that may subside as the dust settles. The official narrative that Iran has scored a major triumph against Israel is a classic case of when George Orwell talks about nationalism and indifference to reality.”

    He claimed that in reality serious discussions were going on within the state about what went wrong, its air defences, the lack of civil defence and the shocking and profound levels of infiltration of the security forces. “People are saying the one thing we thought the Islamic Republic can do is defend us and they cannot even do that. The Islamic Republic that went into this conflict will not be the Islamic Republic that comes out,” he said.

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  • Discover 5 strategies to increase your email marketing response rates

    Discover 5 strategies to increase your email marketing response rates

    Dear faculty and staff,

    The next Circles of Excellence, on Aug. 7, will focus on how to increase your email marketing response rates and better understand your target audience.

    Discover 5 strategies to increase your email marketing response rates

    Ready to boost your email engagement? In this virtual presentation led by Strategic Marketing and Communications, we’ll explore five proven strategies to increase response rates in your email marketing and communications.

    Backed by real-life examples and UIC-specific data, this session will highlight actionable tactics you can start using right away — including A/B testing, audience segmentation, personalized messaging and data-driven decision-making — all within UIC’s official Emma Email Marketing platform.

    When:
    1-2:30 p.m. Thursday, Aug. 7

    Where:
    Virtual via Zoom
    Advance registration is required.

    Who should attend:
    Anyone who creates and sends email marketing campaigns using UIC’s Emma email marketing platform.

    For questions or more information, please email smcs@uic.edu.

    Together, let’s continue to elevate the transformational story of UIC, where access is broad and excellence thrives.

    Gratefully,
    Chandra Harris-McCray, PhD
    Vice Chancellor for Strategic Marketing and Communications

    For more information, please contact:
    Strategic Marketing and Communications
    smcs@uic.edu

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  • Laughter lifts bonobo moods, offering clues to human emotion

    Laughter lifts bonobo moods, offering clues to human emotion

    When humans burst into laughter together, moods lift almost automatically. New research shows that a similar boost happens in our closest cousins.

    An international team led by Indiana University scientists has discovered that bonobos become more upbeat after hearing the giggles of their companions. This finding pushes the evolutionary history of positive emotions back millions of years.

    Laughter changed ape choices


    To explore laughter’s influence, the researchers designed a cognitive-bias test often used in animal psychology to gauge optimism or pessimism.

    First, they trained bonobos at the Ape Initiative in Des Moines, Iowa, to recognize two kinds of boxes: black ones that always contained a delicious snack and white ones that were always empty.

    Once the apes consistently chose black and ignored white, the experimenters introduced a third, ambiguous gray box. They then played one of two sounds: recorded bonobo laughter or a neutral control noise.

    “We know that other apes, like chimpanzees, have contagious laughter during play,” said lead author Sasha Winkler, a primatologist at Duke University. “We were wondering if that behavior could be explained by positive emotions produced from the sound itself.”

    If the bonobos felt a surge of good feeling after hearing laughter, the team expected them to treat the uncertain gray box as if it were the rewarding black one.

    That is exactly what happened. “Think of it like the rose-colored glasses effect,” Winkler said. “The bonobos were much more likely to approach the gray boxes after hearing laughter, treating them like the rewarded boxes, and indicating a more optimistic expectation of finding a treat.”

    Tracing optimism to our ancestors

    This study is the first experimental proof that great-ape laughter can shift mood and cognition the way human laughter does.

    “The tendency to behave more optimistically after hearing laughter suggests that the sound alone induced a positive emotional state in bonobos,” said senior author Erica Cartmill, the director of Indiana University’s Cognitive Science Program.

    “This is the first study of which we’re aware to measure a positive affect shift in nonhuman primates from a brief experimental intervention.”

    Great apes –  bonobos, chimpanzees, gorillas, orangutans – all emit play calls that acoustically resemble human chuckles. Earlier work tied those sounds to a common evolutionary origin. The new findings add a cognitive twist.

    “Our results suggest that laughter in other apes shares not only phylogenetic and behavioral similarities with human laughter but also perhaps some of the same cognitive-emotional underpinnings,” Winkler noted.

    “This emotional contagion appears to have been present in the primate lineage long before the evolution of language.”

    Laughter, empathy, and apes

    Emotional contagion is often described as a foundational element of empathy – the capacity to share another’s feelings. As Winkler put it, “studies like ours can help to untangle the evolutionary building blocks of empathy, communication, and cooperation in humans.”

    By revealing that a simple vocal cue can brighten outlooks in bonobos, the research suggests that the mechanisms linking social sound to positive mood were already in place in a common ancestor millions of years ago.

    Cartmill added that the work answers a long-standing bias in emotion research. “Our emotions influence many aspects of cognition, including memory, attention, and decision-making, but research has historically focused on negative emotions with clear behavioral correlates, like fear and aggression.”

    “We wanted to better understand the relationship between positive affect and cognition in our closest living relatives.”

    Kanzi and the future of empathy

    The experiments involved four bonobos, including the celebrated language-using ape Kanzi, who recently passed away.

    “I feel incredibly grateful to have had the opportunity to work with Kanzi while he was still alive,” Winkler said.

    “We hope this brings greater public awareness of the remarkable similarities between us and bonobos, who are an endangered species. We have so much to learn from these incredible animals.”

    Future studies will test whether laughter exerts similar cognitive effects in chimpanzees and other primates. They will also explore how social context – for example, hearing laughs from friends versus strangers – modulates optimism.

    For now, the discovery that bonobo giggles brighten expectations highlights a shared emotional heritage and hints that a simple laugh has been boosting group spirits since long before humans walked the Earth.

    The study is published in the journal Nature Scientific Reports.

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  • Apple stock fluctuates following report of potential AI partnership for Siri

    Apple stock fluctuates following report of potential AI partnership for Siri

    Investing.com — Apple (NASDAQ:AAPL) shares traded choppily Monday afternoon, paring an earlier decline of 0.7% following a Bloomberg report that the tech giant is considering using external AI technology to power its Siri voice assistant.

    According to the report, Apple has held discussions with both Anthropic and OpenAI about potentially using their large language models to power a new version of Siri. The company has reportedly asked these AI firms to train versions of their models that could run on Apple’s cloud infrastructure for testing purposes.

    Invest in Gold

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    This potential move would mark a significant shift in Apple’s AI strategy. The iPhone maker currently relies on its in-house technology, called Apple Foundation Models, for most of its AI features and had been planning to develop a new version of Siri using this proprietary technology for 2026.

    A decision to adopt Anthropic’s Claude or OpenAI’s ChatGPT models for Siri would signal that Apple is struggling to compete independently in the generative AI space, which has emerged as one of the most significant technological developments in recent years. While Apple already allows ChatGPT to answer web-based search queries in Siri, the assistant itself is currently powered by Apple’s own technology.

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    As stocks notch records, sentiment lags behind, but ’Fed put’ to support bulls

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  • A Super Mario Maker 2 player has cleared an astonishing 1 million levels

    A Super Mario Maker 2 player has cleared an astonishing 1 million levels

    was released six years ago this past Saturday. While Nintendo didn’t do a whole lot to mark the occasion, one of the game’s most dedicated players sure did. DSteves hit a remarkable milestone by becoming the first to clear 1 million SMM2 levels.

    The Twitch and YouTube streamer had hoped to reach that point by the game’s sixth anniversary and got there toward the end of a . In fact, DSteves cleared 1,000 levels during that single stream.

    This embedded content is not available in your region.

    After the 999,999th level clear, an emotional DSteves punched in the code for a custom level a player named raysfire created just for this occasion — you can try it yourself by entering the level ID QKQ-4TD-0DG. Since this is SMM2, of course there was some cheap (or should that be Cheep Cheep?) trolling from raysfire, such as a Question Block that dispensed an enemy instead of a power-up. DSteves died a couple of times while playing this level, including to Bowser fireballs that were disguised by a bunch of coins.

    DSteves said on the stream it took six years and eight hours to beat 1 million SMM2 levels, and then toasted the achievement with some champagne. The vast majority of the level clears, nearly 800,000 of them, occurred in one Endless Challenge streak on Easy difficulty (just slightly more than my current streak of 581). So, DSteves didn’t exactly grind through several hundred thousand ultra-hard kaizo-style stages, but it’s still an impressive achievement.

    To reach the goal, DSteves cleared an average of 456.4 levels per day. The streamer skipped more than 80,000 levels, died more than 772,000 times and hit the million mark with about 165,000 more stage clears than the player in second place (I love that SMM2 shows these stats publicly).

    Despite hitting an astounding number of cleared levels, DSteves isn’t done with SMM2. The streamer was back to playing the game the following night and, at the time of writing, has now beaten 1,000,050 Super Mario Maker 2 stages.

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  • AI-Based Electrocardiogram Interpretation Detects LVSD in Muscular Dystrophy

    AI-Based Electrocardiogram Interpretation Detects LVSD in Muscular Dystrophy

    Routine echocardiographic surveillance in adults with muscular dystrophy may uncover early signs of left ventricular systolic dysfunction (LVSD) and prompt timely intervention, but physical limitations can make consistent monitoring a challenge. Artificial intelligence (AI)–based electrocardiogram interpretation (AI-ECG) could offer a noninvasive, accessible alternative to routine echocardiography, according to findings published in the Journal of the American Society of Echocardiography.1

    “Our findings have potential implications for clinical practice. Current guidelines recommend routine echocardiographic monitoring for muscular dystrophy patients, typically on an annual or biannual basis,” the authors wrote. “However, obtaining high-quality echocardiographic images can be challenging due to patient-specific factors such as scoliosis and muscle weakness. Our findings suggest that AI-ECG could serve as a complementary screening tool, potentially allowing for more flexible and patient-friendly monitoring strategies.”

    Despite the AI-ECG model’s potential, the authors cautioned it must be evaluated in a structured clinical framework to ensure that it improves established monitoring methods rather than replaces them. | Image credit: Yan – stock.adobe.com

    Cardiac complications are substantial contributors to mortality in muscular dystrophies, including Duchenne muscular dystrophy (DMD), in which up to 70% of patients experience LVSD.2 Despite the recommendations for regular electrocardiography, capturing high-quality echocardiographic images can be challenging for patients with muscular dystrophy due to scoliosis, muscle weakness, immobility, and other physical limitations, the authors noted.1

    “Given these limitations and the current pressure on echocardiography availability in our health care systems, alternative methods for LVSD risk stratification are urgently needed,” the authors wrote. “[AI] applied to [AI-ECG] has shown promise for predicting LVSD in various populations. An ECG is widely accessible, cost-effective, and quick to perform (also in immobile populations), with the potential for home monitoring applications.”

    The researchers identified patients with DMD, Becker muscular dystrophy, limb-girdle muscular dystrophy, or myotonic dystrophy who were 16 years or older and underwent an ECG and transthoracic echocardiogram within 90 days of each other at the University Medical Center Utrecht hospital in the Netherlands between 2007 and 2023. The data pool also included female carriers of DMD or BMD, who are also at a higher risk of cardiac complications.

    A convolutional neural network was first trained using a derivation cohort of 53,874 ECG-echocardiogram pairs from 30,978 patients without muscular dystrophy to detect LVSD, then it was tested on a set of 390 ECG-echo pairs from 390 patients with muscular dystrophy. The researchers used a Cox proportional hazards model to determine the predictive value of AI-ECG for new-onset LVSD.

    Follow-up echocardiography was available for 177 patients without LVSD at baseline. At a median follow-up of 4.8 (IQR, 2.6-8.6) years, LVSD occurred in 92 (52%) patients. LVSD prevalence ranged from 13.4% in patients with myotonic dystrophy to 81.3% in patients with DMD. No BMD female carriers showed LVSD, but 17.4% of DMD carriers had LVSD.

    In the validation set, the model achieved an area under the receiving operator curve (AUROC) of 0.86 (95% CI, 0.85-0.88), sensitivity of 0.90 (95% CI, 0.88-0.92), and specificity of 0.58 (95% CI, 0.56-0.60). In the muscular dystrophy test set, the model demonstrated an AUROC of 0.83 (95% CI, 0.79-0.87), sensitivity of 0.87 (95% CI, 0.81–0.93), and specificity of 0.58 (95% CI, 0.52-0.63). The negative predictive value was 0.91 (95% CI, 0.86-0.95), and the positive predictive value was 0.49 (95% CI, 0.43-0.53).

    The model overall showed an AUROC of 0.72 (95% CI, 0.66-0.78) for predicting new-onset LVSD, and the AI-ECG probability was a significant predictor of LVSD occurrence.

    Despite the model’s potential, the authors cautioned that timely diagnosis of LVSD and initiation of cardioprotective treatment are crucial. Therefore, AI-ECG must be evaluated in a structured clinical framework to ensure that it improves established monitoring methods rather than replaces them. The clinical utility, cost-effectiveness, and optimal integration of AI-ECG into current care standards must also be determined through prospective studies and cluster randomized trials, they added. Their study was also limited by its single-center nature and reliance on routine clinical interpretation of echocardiograms.

    “This study demonstrates that AI-ECG can accurately detect and predict LVSD in muscular dystrophy patients, offering a non-invasive, widely accessible, and applicable tool for cardiac risk stratification,” the authors concluded. “The ability to detect and predict LVSD may enable more personalized follow-up strategies, reducing reliance on echocardiography. Future research should focus on external validation and pediatric application.”

    References

    1. Arends BKO, Zwetsloot PM, Heeres PS, et al. Left ventricular systolic dysfunction screening in muscular dystrophies using deep learning-based electrocardiogram interpretation. J Electrocardiol. Published online June 12, 2025. doi:10.1016/j.jelectrocard.2025.154048

    2. Verhaert D, Richards K, Rafael-Fortney JA, Raman SV. Cardiac involvement in patients with muscular dystrophies: magnetic resonance imaging phenotype and genotypic considerations. Circ Cardiovasc Imaging. 2011;4(1):67-76. doi:10.1161/CIRCIMAGING.110.960740

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  • Scientists thought they found a ‘zombie’ in space. Turns out, it was something even stranger

    Scientists thought they found a ‘zombie’ in space. Turns out, it was something even stranger

    In June last year, astronomers scanning the sky from the remote deserts of Western Australia picked up a sudden, blinding burst of radio energy. The signal was so powerful, it temporarily outshone every other radio source in the sky, according to a report of CNN.

    At first, the team at Curtin University believed they had discovered something extraordinary — perhaps a new type of astronomical object or an ultra-rare fast radio burst (FRB) from within our galaxy.

    “We were really excited,” Dr. Clancy James, associate professor at Curtin’s Institute of Radio Astronomy, told CNN. “It looked like we had found an unknown object near Earth.”
    The data came from the ASKAP telescope, an advanced array of 36 large antennas spread across the Wajarri Yamaji Country in Western Australia. This setup is usually used to detect FRBs — intense, millisecond-long bursts of radio energy from distant galaxies, potentially caused by exotic phenomena like magnetars, the ultra-magnetic remains of dead stars.

    These bursts are not only puzzling but also powerful tools for mapping the “missing” matter in the universe. But this particular signal wasn’t behaving like a normal FRB.


    Unlike typical FRBs that originate billions of light-years away, this burst appeared to be shockingly close — just 4,500 kilometers (2,800 miles) from Earth. When the team zoomed into the data, the image became blurry — a telltale sign the source was much closer than expected.After sifting through satellite databases, the astronomers matched the source to Relay 2, a long-defunct U.S. communications satellite launched in 1964. Relay 2 had been orbiting silently since its instruments failed in 1967.But this sparked an even more bizarre question: Could a dead satellite suddenly burst back to life?

    A Flash from the Past
    The leading theory is an electrostatic discharge — a burst of energy caused by a buildup of electric charge on the satellite’s surface, similar to the shock you get from touching a doorknob after walking on carpet. When the charge releases, it can emit a sharp flash of radio energy.

    While these discharges are common and often harmless, the intensity and brevity of this one — just 30 nanoseconds long — was unprecedented. In fact, it was 2,000 to 3,000 times brighter than any other signal the ASKAP instrument typically detects.

    Another possibility, though less likely, is that a micrometeorite no larger than a grain of sand slammed into Relay 2 at extreme speed, causing a burst of plasma and radio waves. However, the team estimates there’s only about a 1% chance that was the cause.

    Why This Matters
    Although this turned out to be a human-made source, the discovery underscores a major challenge in space research: the interference of space junk with astronomical observations. With over 22,000 satellites launched since the dawn of the space age — and thousands no longer functional — Earth’s orbit is becoming a crowded and unpredictable place.

    Signals like the one from Relay 2 could easily be mistaken for cosmic phenomena, especially as ground-based observatories like ASKAP and upcoming arrays such as SKA-Low (Square Kilometre Array) continue to scan the skies for fast, faint signals.

    While this unexpected “zombie signal” turned out to be from a defunct satellite, it opens up new possibilities for using radio telescopes to monitor aging spacecraft for signs of unusual activity.

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  • White House says Canada’s Carney ‘caved’ to Trump on tech tax

    White House says Canada’s Carney ‘caved’ to Trump on tech tax

    The White House said Canadian Prime Minister Mark Carney “caved” to pressure from President Donald Trump in rescinding a tax on big US technology firms.

    White House Press Secretary Karoline Leavitt told reporters on Monday Canada had made a mistake in trying to levy the tax, and that Carney called Trump on Sunday evening to say he would drop it.

    Since Trump returned to office, the two countries have been fighting over trade. In response to the tax, which he called a “blatant attack”, Trump on Friday called off trade deal negotiations and threatened to raise tariffs.

    Canada then said it would halt collection of payments, which were due on Monday, and introduce legislation to scrap the tax.

    “President Trump knows how to negotiate, and he knows he is governing the best country and the best economy in this world,” Leavitt said in response to a question from a reporter.

    “Every country on the planet needs to have a good relationship with the US,” she said, and called removal of the tax a “big victory for our tech companies and our workers here at home”.

    Canada’s digital services tax (DST) would have meant US tech giants including Amazon, Meta, Google and Apple faced a 3% charge on Canadian revenue above $20m (£15m).

    On Sunday, Canada’s finance minister, François-Philippe Champagne, issued a statement saying the tax would be rescinded.

    “The DST was announced in 2020 to address the fact that many large technology companies operating in Canada may not otherwise pay tax on revenues generated from Canadians,” he said.

    “Canada’s preference has always been a multilateral agreement related to digital services taxation,” the statement added.

    Pierre Poilievre, the leader of Canada’s opposition Conservative Party, criticised scrapping the tax at the “11th hour”.

    In a post on X, he said the prime minister had “put his elbows down” – in reference to the “elbows up” phrase used by Carney and his Liberal Party when campaigning in this April’s election to signify they were prepared to defend Canadian interests against the US.

    Poilievre urged Carney to “insist that the US immediately rescind softwood lumber tariffs” in exchange, adding that “we need to make gains for our workers in these talks”.

    Many countries, including the UK, are changing how they tax large multinational technology firms, which have millions of customers and advertisers around the world, but high corporation tax bills due to the way their businesses are structured.

    It was estimated that Canada’s tax would cost the tech giants more than C$2bn ($1.5bn; £1.06bn) in its first year as the tax was being applied retroactively to January 2022.

    Last year’s federal budget estimated the tax would bring in C$5.9bn in total over the next five years.

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  • João Fonseca handles nerves amid partisan crowd for debut victory against Jacob Fearnley

    João Fonseca handles nerves amid partisan crowd for debut victory against Jacob Fearnley

    Wimbledon 2025 – João Fonseca keeps calm, carries on, reaches round two

    Fonseca admitted after the match that he was feeling the nerves – coming into his Wimbledon debut against a Briton is no easy welcome to the Championships.

    But the world No.54 looked as if he had been playing at SW19 since he was born, so co-ordinated with each shot and winning 84 per cent of his points on first serve.

    This also marks the Brazilian’s third consecutive debut triumph in a Grand Slam main draw, achieving victory on his maiden outings at both the Australian Open and French Open this year.

    “Probably the place that you play, you just feel like you want to win a lot,” Fonseca explained of what brings out the best of him at majors. “You’re playing a Grand Slam. It’s an opportunity. It’s once in a year, so you just give it all. I was very focused today and I gave my best. So I’m very happy, I worked very much for this one.”

    For Fearnley, he falls short of consecutive second-round appearances at Wimbledon and bids farewell to the home crowd, who roared him on through the challenging conditions in south-west London.

    On the other side of the net, Fonseca looks to just be getting started. At the tender age of 18, he is the first player that young to reach the Wimbledon men’s singles second round since Carlos Alcaraz in 2021.

    Having reached the second round at Melbourne Park and the third round at Stade Roland-Garros, what lies in store for the boy from Rio de Janeiro at the Championships 2025?

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