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  • International Case Series Reveals Meningitis as a Potential Underrecognized Feature of MOGAD

    International Case Series Reveals Meningitis as a Potential Underrecognized Feature of MOGAD

    Eoin P. Flanagan, MB, BCh

    (Credit: Mayo Clinic)

    In a research letter recently published in JAMA Neurology, researchers highlighted that meningitis could be a feature of myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). Using data from a prior study that investigated the frequency and characteristics of meningitis in MOGAD, this potential feature was not included in the 2023 diagnostic criteria for the disease.1,2

    The previous study featured 810 patients with MOGAD, 34 (4%) of which had meningitis, with symptoms or signs at presentation that included headache (94%), fever (62%), nausea/emesis (56%), encephalopathy (50%), photophobia (38%), seizure (35%), nuchal rigidity (24%), or papilledema (12%). Notably, researchers noted that elevated cerebrospinal fluid (CSF) opening pressure occurred in 11 out of 18 patients with MOGAD in the study and 7 of the patients experienced leptomeningeal changes on their initial MRI scan.

    “A meningitis attack phenotype occurred in 4% of the MOGAD cohort,” senior author Eoin P. Flanagan, MB, BCh, professor of neurology and chief of the Division of Multiple Sclerosis and Autoimmune Neurology at Mayo Clinic, and colleagues wrote in the published research letter.1 “Given that 50% of the cohort developed intra-attack encephalopathy, evolved into a typical core demyelinating event, or both, meningitis may at times represent an early manifestation of meningoencephalitis or parenchymal disease, with demyelinating lesions initially absent due to radiologic lag.”

    “All cases met the definition of aseptic meningitis, misdiagnoses and antimicrobial use were frequent, and MOG IgG testing and immunotherapy administration were often delayed, suggesting that meningitis/meningoencephalitis is an underrecognized feature of MOGAD attacks. Future updates of MOGAD diagnostic criteria could add meningitis/meningoencephalitis as an attack type, allowing earlier testing, diagnosis, and treatment before onset of parenchymal disease,” Flanagan et al noted.

    This international study identified patients with MOGAD across 11 centers who had at least 1 symptom or sign of aseptic meningitis per criterion, CSF white blood cell count greater than 5/μL; MOG IgG positivity, absence of infectious or alternative etiologies, and lack of parenchymal brain involvement on MRI. Researchers tested the serum and CSF samples from the precipitants by fixed or live MOG IgG cell-based assay or both. In addition, pathology (n = 1) was assessed through EnVision FLEX (Dako) immunohistochemistry as performed previously.3 Investigators also reported the collected clinical variables from electronic medical records using descriptive statistics.

    READ MORE: Mendelian Randomization Analysis Identifies Neuroprotective and At-Risk Proteins for NMOSD

    In the research letter, authors noted that serum MOG IgG titers were assessed in 34 patients (live, n = 28; fixed, n = 6) and categorized as clear positive (n = 20), low positive (n = 3), or unavailable (n = 11). Among patients without a prior diagnosis of MOGAD, the median time for MOG IgG testing was 43 days (IQR, 12–563). Additionally, CSF MOG IgG was positive in all 5 patients who underwent CSF testing.

    All patients initially presented with suspected infectious meningitis, with 68% who received antimicrobials and 32% who received first-line immunotherapy in a median of 10 days (IQR, 6.5–11.5) from presentation. In 1 patient, brain and meningeal biopsy revealed meningeal infiltration by CD4+ T cells, CD20+ B cells, and microglia, along with cortical subpial demyelination and remyelination; MOG immunostaining was absent in normal control meninges.

    Authors also noted that 3 of the meningitis attacks presented in the study were initially attributed to MOGAD, which included 2 relapse attacks. In the group of patients with meningitis, 17 of them developed new clinical features or MRI lesions representing an evolution to a core demyelinating event in a median of 17 days (IQR, 11-25). At last follow-up, 27 of 34 patients fulfilled MOGAD criteria, and the 7 remaining patients had a single monophasic meningitis attack (clear positive, n = 6; persistent positive without titers available, n = 1).

    “Lack of MOG immunostaining in control meninges and transcriptomic data showing absent or extremely low MOG in human meninges make it unlikely to be the primary target. A cortical MOG origin with secondary meningeal inflammation is possible, given the cortical demyelination pathologically and insensitivity of MRI for cortical involvement, or MOG may not be the primary initiating antigenic target,” Flanagan et al noted in the letter.1 “This study is limited by its retrospective nature. Expanding the MOGAD spectrum requires caution because low-titer MOG IgG may occur with other diseases, but most patients fulfilled MOGAD criteria and had a clear positive MOG IgG result without alternative etiologies identified.”

    REFERENCES
    1. Aboseif A, Kim NN, Bou G, Nathoo N, Guo Y, Pique J, Kerbrat A, Audoin B, Demortiere S, Bourre B, Ciron J, Chen JJ, Cacciaguerra L, Toledano M, Quek AML, Gombolay G, Marignier R, Hacohen Y, Flanagan EP. Meningitis as an Attack Phenotype of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. JAMA Neurol. 2025 Jun 16. doi: 10.1001/jamaneurol.2025.1774. Epub ahead of print. PMID: 40522676.
    2. Gu M, Mo X, Fang Z, Zhang H, Lu W, Shen X, Yang L, Wang W. Characteristics of aseptic meningitis-like attack-an underestimated phenotype of myelin oligodendrocyte glycoprotein antibody-associated disease. Mult Scler Relat Disord. 2023 Oct;78:104939. doi: 10.1016/j.msard.2023.104939. Epub 2023 Aug 16. PMID: 37611382.
    3. Höftberger R, Guo Y, Flanagan EP, Lopez-Chiriboga AS, Endmayr V, Hochmeister S, Joldic D, Pittock SJ, Tillema JM, Gorman M, Lassmann H, Lucchinetti CF. The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody. Acta Neuropathol. 2020 May;139(5):875-892. doi: 10.1007/s00401-020-02132-y. Epub 2020 Feb 11. PMID: 32048003; PMCID: PMC7181560.

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  • Thom Browne Makes His Mark With Two New Boutiques on Madison Avenue

    Thom Browne Makes His Mark With Two New Boutiques on Madison Avenue

    On Wednesday evening, a stylish crowd clad in seersucker suits, sharply tailored grey blazers, and pleated skirts gathered on East 72nd Street, pausing to admire a shrub trimmed into the shape of Thom Browne’s iconic Hector bag, complete with a red, white, and blue striped ribbon for a collar. The playful topiary signaled what they’d come for: the debut of Browne’s latest venture.

    The designer officially opened two new boutiques on the Upper East Side’s luxury shopping corridor, marking his first retail expansion in New York City since 2006. One space houses his full men’s and women’s ready-to-wear collections; the other is Browne’s first-ever accessories-only boutique, dedicated to leather goods, footwear, eyewear, and fragrances. His original flagship remains downtown at 100 Hudson Street in Tribeca.

    Located at 19 East 72nd Street, the 1,700-square-foot ready-to-wear boutique echoes Browne’s signature mid-century modern aesthetic, but with a warmer, more residential atmosphere. Wooden slat blinds replace aluminum, and silver travertine stone lines the floors and walls. Overhead, a grid of wood lattice ceiling lights casts a soft glow over curated furniture pieces by Jacques Adnet and Edward Wormley—designers Browne personally admires.

    Just around the corner, at 898 Madison Avenue, the intimate 900-square-foot accessories boutique showcases Hector bags (modeled after Browne’s beloved dachshund), structured handbags, fragrances, eyewear, and footwear. Both spaces were designed by Browne himself to offer more than just retail—it’s about creating a fully immersive brand experience.

    “It’s a long time coming, and it’s nice to have a store in my neighborhood,” Browne told Vogue, as he hosted a cocktail reception in the ready-to-wear store to toast the openings. “It’s always been the idea to have something on Madison Avenue. But when I first started out, I didn’t think about anything other than making my clothes. Now, to have the stores open here—it feels great. It’s nice that everyone gets to experience what I want them to experience, exactly how I want them to experience it. It’s about housing and showcasing the different parts of the collection.”

    Around 145 guests mingled amid the new boutiques, sipping champagne and sampling chocolate gelato and raspberry sorbet. Christine Baranski, in a navy pleated skirt suit, was among the first to arrive, later linking up with her Gilded Age co-star Louisa Jacobson, who wore a denim Thom Browne skirt and top. Emmy nominees Cristin Milioti and Tramell Tillman, Past Lives director Celine Song, Kim Kardashian’s hairstylist Chris Appleton, and The White Lotus star Walton Goggins also made appearances. Goggins, after browsing a rack of crisp Oxford shirts, shared a conversation with Browne.

    “I think you enter a whole new universe when you’re wearing his clothes,” Goggins said. “The framework he’s created—his artistic expression—it’s so authentic and one of a kind. His clothes make you feel special.”

    With his new Madison Avenue outposts now open, Browne shows no signs of slowing down. “There’s still so much to do—the next collection, for starters,” he said. “This is just part of the growth of everything that’s going on. But I’m really proud of what we’ve accomplished.”

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  • Ted Sarandos Says AI Will Make Movies, TV “Better, Not Just Cheaper”

    Ted Sarandos Says AI Will Make Movies, TV “Better, Not Just Cheaper”

    Netflix co-CEO Ted Sarandos sees generative artificial intelligence tools expanding creativity during the making of movies and TV series and not just being a cost-cutting option for studios.

    “We remain convinced that AI represents an incredible opportunity to help creators make films and series better, not just cheaper,” Sarandos told financial analysts on Thursday after his company delivered its second quarter financial results.

    “So this is real people doing real work with better tools. Our creators are already seeing the benefits in production through pre-visualization and shot planning work, and certainly visual effects,” he added.

    And not just on bigger budget projects. Sarandos pointed to El Eternauta (The Eternaut), an Argentine sci-fi series that follows survivors of a sudden and devastating toxic snowfall and which made use of virtual production and AI-powered visual effects tools.

    In the first-ever generative AI footage to stream as part of a Netflix original series or film, Sarandos said Netflix and Argentinian VFX artists collaborated to show a building collapsing in Buenos Aires.

    “Using AI-powered tools, they were able to achieve an amazing result with remarkable speed and, in fact, that VFX sequence was completed ten times faster than it could have been completed with traditional VFX tools and work flows,” he recounted. And using AI tools enabled the use of VFX in a six-part series made entirely by an Argentine cast and crew and with a budget lower than is typical for big budget Hollywood productions.

    “The creators were thrilled with the result. We were thrilled with the result, and more importantly the audience was thrilled with the result. So I think these tools are helping creators expand the possibilities of storytelling on screen, and that is endlessly exciting,” Sarandos told analysts.

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  • Six Gunners involved in Euro quarter-final chaos | International | News

    Six Gunners involved in Euro quarter-final chaos | International | News

    Chloe Kelly was the super substitute, providing one assist, one pre-assist, and scoring in the penalty shootout, after coming off the bench as England came from 2-0 down to beat Sweden in the UEFA Women’s Euro 2025 quarter-finals on Thursday.

    Michelle Agyemang, also off the bench, scored England’s all important equaliser, assisted by another Gunners substitute, Beth Mead.

    A comeback seemed a long way off for the majority of the game after Stina Blackstenius’ sensational summer continued with a goal and assist for Sweden.

    Their high press hurt the Lionesses straight away as Blackstenius teed up Kosovare Asllani to provide an early lead.

    Our UEFA Champions League final winner then got herself on the scoresheet, appearing to shatter England’s dreams of retaining the trophy.

    Read more

    Stina Blackstenius: She’s always scored the goals

    But Kelly made an instant impact after coming on, her cross headed in by Lucy Bronze, before her next delivery was touched down by Mead, allowing Agyemang to convert.

    Leah Williamson and Alessia Russo also got 105 and 120 minutes respectively for the Lionesses.

    Then, on penalties, after one of the most bizarre shootouts, England won 3-2 with the two sides missing nine penalties in total, including Sweden goalkeeper, Jennifer Falk, who took their fifth.

    Russo scored England’s first penalty, while Kelly was next to score for the Lionesses, before Lucy Bronze set the shootout up for Smilla Holmberg’s decisive miss.

    Up next, England will play Italy in the semi-final at 8pm on Tuesday, July 22, while Mariona Caldentey and Lia Walti will be involved in tomorrow’s quarter-final between Spain and host nation Switzerland.

    Copyright 2025 The Arsenal Football Club Limited. Permission to use quotations from this article is granted subject to appropriate credit being given to www.arsenal.com as the source.

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  • Fears proposed energy park could hurt Galloway’s dark sky status

    Fears proposed energy park could hurt Galloway’s dark sky status

    Jamie Russell

    BBC Scotland News

    Matthew, Dark Sky Ranger The northern lights. Vivid colours of yellow-green and pink scattered through a dark night sky with light cloud cover. A shadow of a person [centre] is facing away from the camera while looking up at them. They are surrounded by dark shrubbery.Matthew, Dark Sky Ranger

    Low light pollution means visitors can see amazing sights when looking up

    Campaigners are concerned that the UK’s first Dark Sky Park could see its status at risk if a proposed energy development is approved.

    The Galloway site was first recognised in 2009 as one of the best places to view the night sky with the naked eye.

    The proposed Lairdmannoch Energy Park sits outside the park’s boundary and buffer zone but planning documents show wind turbines and safety aviation lights would be visible from the area.

    The new site’s developer – Wind2 – says the company is “very aware” of the dark sky status and the value of “preserving the area’s natural light skies.”

    Aviation lights are an essential safety measure in tall developments to mitigate the risk of collision.

    The proposed development includes both red “medium-intensity” lights and infrared lights invisible to the eye.

    Developers say only four of the proposed nine 180m (590ft) wind turbines would include red aviation lights, after consultation with the Civil Aviation Authority.

    They also stress the energy park was not within the Dark Sky Park or its designated buffer zone.

    Matthew, Dark Sky Ranger A visitor to the park uses astrobinoculars - the brighest light in the sky is JupiterMatthew, Dark Sky Ranger

    The park secured its status back in 2009

    Matthew McFadzean is one of two dark sky rangers at the Galloway Forest Park.

    He said the project created a “detrimental” threat to night time visibility.

    “You can come to Dumfries and Galloway and experience a really good level of light quality at night and night vision across the region,” he said.

    “But if you go into the Dark Sky Park, that’s where you get the absolute best.”

    Mr McFadzean believes visibility of the night sky has improved thanks to the lighting policies of the local authority over the two decades since the area secured its dark sky status.

    However, he said he concerned there had been an increasing encroachment of renewable energy developments on the park’s boundaries.

    He said he understood the need to support the transition to renewable energy but added that red light – although it has a smaller impact than white light – could still harm night time visibility.

    “It will really impact things,” he said.

    “In the Dark Sky Park, you can look up and see with the naked eye, thousands and thousands of stars on a clear night – more than people from the cities who come to visit can ever imagine.

    “The one word which people say the most when they actually experience looking up at a dark sky for the first time is wow and if we put red lights up there I think that can only be detrimental to that experience.”

    Matthew, Dark Sky Ranger A view of the night sky over Clatteringshaws Loch with a single light in the distance shining outMatthew, Dark Sky Ranger

    Ranger Matthew McFadzean said this picture at the shore of Clatteringshaws Loch shows how light impacts horizon views

    His concerns are shared by by Fi McClelland of The Scottish Dark Sky Observatory, which has plans to build a new facility in the park to replace the previous one, which was destroyed by fire.

    She said the red light effect could be scattered through the sky by clouds or cause a disruptive “sky glow” across the wider region.

    Campaigners say the elevated position of the turbines will see them dominate the landscape.

    “The combination of them both is over 1,300ft from sea level to the tip of the turbine – that’s bigger than the Empire State Building without its antenna,” resident Matthew James said.

    Matthew, Dark Sky Ranger A colourful sky over Galloway with hints of purple, green and dark blue and the silhouette of a treeMatthew, Dark Sky Ranger

    The fate of the energy park proposals will be decided by the Scottish government

    As well as the impact on the dark sky park, locals have raised concerns about the effect of the wind turbines on wildlife and the local water system.

    But developer Wind2 said it had been working with the community for two years and had taken steps to mitigate risks including potential threat to night time visibility and wildlife.

    It added it believed the area should see “tangible benefits from local renewable energy projects”.

    It has estimated community benefit funding of £310,000 per year would add up to £12.4m over its operational life.

    It said the scheme – which also includes solar panels and battery storage – matched Scottish government’s best practice guidance and could meet the energy needs of up to 67,000 homes.

    The company stressed it had taken every effort to make the turbines “as inconspicuous as possible from sensitive areas”.

    The window for the public to comment on the proposals is about to close.

    The Scottish government – which will decide the fate of the scheme – said it would not be appropriate to comment on a live planning application.

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  • Aberdeen woman discovers hundreds of bats living in her home

    Aberdeen woman discovers hundreds of bats living in her home

    Rachel Bell

    BBC Scotland News

    BBC A woman with blonde hair tied up in a ponytail is wearing a pink and grey checked shirtBBC

    Anne-Marie Murchie says she can’t sleep at night because of the noise made by the bats

    A woman has been forced to sleep in her car after discovering hundreds of bats roosting in her home – and being told there is nothing she can do to remove them.

    Anne-Marie Murchie says she is “living in fear every day” after discovering a colony of more than 500 of the protected animals in the walls and roof of her house in Aberdeen.

    She first heard flapping noises in the walls and later discovered a bat hiding in her toilet roll holder. She has since found more in the living room and kitchen.

    The NatureScot agency says it cannot remove bats from homes and has advised Ms Murchie that the animals will leave of their own accord at the end of the “maternity season” in August or September.

    Anne-Marie Murchie A brown bat sitting crawling along a black and white tiled florrAnne-Marie Murchie

    The bats have been spotted throughout the house, including in the kitchen

    That has been of no comfort to Ms Murchie, who says her anxiety is “through the roof” from the sound of the bats’ constant movement.

    She told BBC Scotland News: “They’re above the spotlights in the kitchen and they’ve popped them out a few times as well.

    “I’m scared to come in the house. Sometimes I actually sleep outside in the car. I’m just petrified.

    “The noise is horrendous, it’s like running water. But I think it’s all the wings going together, like flapping.

    “It never stops. They get louder at about five or six at night and then when they come in at five in the morning. But they’re constantly making noise. I wonder if they sleep.”

    The bats colonising Ms Murchie’s home are soprano pipistrelles, which are among the most common and widespread of British bat species.

    Anne-Marie Murchie A gloved hand holds a brown bat with its teeth showing and a wing hanging downAnne-Marie Murchie

    One bat found in the house was returned to the rest of the group

    They are known to form colonies well in excess of 200 adult animals – plus their offspring.

    NatureScot said these bats are usually seasonal visitors to houses and are present for four or five months of the year.

    They form maternity colonies in May and June and leave in August and early September, once the young bats are independent.

    NatureScot’s bat workers can collect information and advise homeowners on problems they have with the animals.

    But it says they “cannot carry out any works to your building or exclude/take away the bats”.

    The agency’s Kevin Giles told BBC Scotland News: ”With regard to what you can do with them, actually nothing, because they are a protected species under European protection laws and Scottish and UK laws.

    “So the bats themselves can’t be touched, nor can the roosts.”

    Getty Images A library picture of a soprano pipistrelle bat which has light brown furGetty Images

    The soprano pipistrelle bat is known to form colonies in properties between May and September (library picture)

    Ms Murchie first became concerned about a constant noise in her house a few months ago and believed it must be down to a wasps’ nest.

    But a pest control officer told her it was actually bats after looking at doorbell camera footage and seeing them outside.

    “We found out they were protected so we went through the proper channels and called Nature Scotland,” Ms Murchie said.

    “They then came out with thermal cameras and that gave them an idea of how many bats there are and all the entry points in the house.

    “It was about 500 bats at least and about 200 to 300 babies. But now we’ve found another site so they’re coming back next week to see how many are there.

    “It’s absolutely awful. I actually moved out because I couldn’t bear to live in the house. You can’t come in or out at certain times because there’s hundreds of them.”

    Anne-Marie Murchie A black bat curled up next to a white window frameAnne-Marie Murchie

    Bats have been spotted curled up inside and outside the house

    Ms Murchie returned to her house after a few weeks in the hope that the bats had left.

    “I thought, they’re definitely not in the house,” she said “but then I got up one night and went to the loo.

    “Half asleep, I grabbed the toilet roll holder and one came out and held on to my hand. I just flipped.”

    She added: “I phoned Nature Scotland and they came straight out. She (the bat expert) took her outside and put it back up beside the roost so she could go back up to her home.”

    Ms Murchie, who is a taxi driver, says she now spends as much time as possible working in her car to get away from the sights, sounds and smells in her house.

    “The smell comes through the fan. It’s like a musty, dirty smell.

    “It’s sad that you can’t do anything about it in your own home.

    “I feel like the rules should change a bit. Surely someone can come in that’s licensed and take them away to somewhere humanely?”

    Licence to seal

    NatureScot has told Ms Murchie an officer will return to her house next week to update the situation.

    She said: “Once they’ve checked that the bats are gone, I can get a special licence and it’s confirmation that I can seal up all the potential entry points. So that when they come back next year they won’t be able to get in.”

    NatureScot says people affected can call its Bats in Houses helpline on 01463 725 165 or email batsinhouses@nature.scot

    Anyone who finds a grounded bat in their property can also call either the Bat Conservation Trust Bat Helpline (0345 1300 228) or the SSPCA Animal Helpline (03000 999 999) for advice on how to best handle and remove the bat.

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  • Google rolling out Android 16 QPR1 Beta 3 for Pixel

    Google rolling out Android 16 QPR1 Beta 3 for Pixel

    Ahead of the stable launch in September, Google is rolling out Android 16 QPR1 Beta 3 to Pixel devices today.


    Everything new in Android 16 QPR1 Beta 2 [Gallery]


    Quarterly Platform Releases deliver more significant changes compared to monthly bug fixes. Historically, QPRs are relatively stable and launch as betas rather than developer previews. Google officially says they are “suitable for general use,” with Android 16 QPR1 expected to launch in September.

    What’s fixed this month:

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    • An issue around RTOS task list corruption that was causing restarts. (Issue #420999948, Issue #426316038)
    • Launcher not completely displaying (Issue #428088033, Issue #428405658, Issue #429817851)
    • Notification display issues (Issue #421792538, Issue #422749237, Issue #420418750, Issue #428896474)
    • The media player in the notification pulldown fails to fully display and function. (Issue #419184923, Issue #421879049, Issue #421810067, Issue #423172198, Issue #422560004, Issue #424116279)
    • Full phone restart due to class loader issues (Issue #427676713)
    • Kernel issue causing restarts (Issue #408888279, Issue #409949346, Issue #409960197, Issue #410624610, Issue #407373090, Issue #430095518)
    • Camera non-functional at startup with black screen (Issue #421870862, Issue #420725698)
    • Status bar icons missing corner padding (Issue #419573315, Issue #419134909)
    • Notification shade message folding breaks (Issue #421366916)

    The Android Beta Feedback app is available on Pixel devices to submit problems. You can access it from the app drawer or via Quick Settings to file bugs in the Google issue tracker, while the Android Beta community is on Reddit.

    Android 16 QPR1 Beta 3 (BP31.250610.004) with the July 2025 security patch is available for the Pixel 6, Pixel 6 Pro, Pixel 6a, Pixel 7, Pixel 7 Pro, Pixel 7a, Pixel Tablet, Pixel Fold, Pixel 8, Pixel 8 Pro, Pixel 8a, Pixel 9, Pixel 9 Pro, Pixel 9 Pro XL, Pixel 9 Pro Fold, and Pixel 9a, as well as the Android Emulator.

    Most people will be installing via the Android Beta Program, but you can also flash or sideload.

    The on-device OTA on a Pixel 9a is 529 MB.

    • Pixel 9a — OTA
    • Pixel 9 Pro Fold — OTA
    • Pixel 9 Pro XL — OTA
    • Pixel 9 Pro — OTA
    • Pixel 9 — OTA
    • Pixel 8a — OTA
    • Pixel 8 Pro — OTA
    • Pixel 8 — OTA
    • Pixel Fold — OTA
    • Pixel Tablet — OTA
    • Pixel 7a — OTA
    • Pixel 7 Pro — OTA
    • Pixel 7 — OTA
    • Pixel 6a — OTA (not currently available)
    • Pixel 6 Pro — OTA
    • Pixel 6 — OTA

    FTC: We use income earning auto affiliate links. More.

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  • Google adds new features in Search as AI race intensifies

    Google adds new features in Search as AI race intensifies

    Google further expanded its strategy for AI search by including Gemini 2.5 Pro and Deep Search in its longtime market-dominating Google Search platform. This move comes as it continues to face stiff competition from OpenAI, which on Thursday introduced a ChatGPT agent.

    The tech giant on July 16 revealed that Google AI Pro and AI Ultra subscribers can now select the Gemini 2.5 Pro multimodal model from a drop-down menu in the AI Mode tab in Search. Subscribers also can now access Deep Search, Google’s advanced tool for in-depth research.

    Google is also bringing a new agent capability into Search: AI-powered calling to certain local businesses. Users can ask Search to call businesses to get pricing and availability. The business calling feature is now available to all Search users. An automated voice generated by the Google Duplex platform informs businesses that an AI system is calling, and users receive the information by text. Humans will intervene in the process when necessary, according to Google.

    The new capabilities in AI Mode and Search are part of Google’s continual refinement of its search strategy as generative AI (GenAI) pioneer OpenAI and AI search vendor Perplexity seek to disrupt the cloud provider’s dominance. They also arrive in a market in which users are turning to large language models (LLMs) such as OpenAI’s ChatGPT to answer questions rather than using Google as their main tool for search.

    “We’re going to become increasingly comfortable with AI searching on our behalf, other than us doing the search,” said Forrester Research analyst Nikhil Lai.

    A day after the Google release, OpenAI launched ChatGPT agent, which enables users to ask ChatGPT to manage personal assistant-like tasks such as planning and buying ingredients for a breakfast, analyzing competitors, booking reservations or creating a slide deck. ChatGPT also has a visual browser that interacts with the web through a graphical UI and a text-based browser for simpler, reasoning-based web questions. Users can connect it to Gmail, GitHub or even direct it to log in to any website and allow it to dig deeper and more broadly.

    If the OpenAI agent works as advertised, it would realize some of the potential that Apple, for example, flaunted when it introduced Apple Intelligence just over a year ago. Most of those agentic features aren’t operational yet and it’s unclear when they will be.

    Trust and consistency

    While ChatGPT agent represents distinct momentum for OpenAI, as the AI vendor and Perplexity continue to erode, if slowly, Google’s dominance in search. However, Google is still a primary trusted resource, and many users return to the search giant when ChatGPT or Perplexity produces a response that seems wrong or suspicious.

    “Trust continues to be Google’s superpower,” Lai said.

    Google also has a better reputation among enterprises for consistency with its Gemini GenAI products than Perplexity or OpenAI in terms of making sure its technology performs the same way all the time, regardless of cost, said Bradley Shimmin, an analyst with Futurum Group.

    “They have a very generous free tier for developers to entice them to go buy into the Google Cloud platform and put their gravity into that platform going forward, and doing that while still being able to deliver high-quality consistency without a lot of latency is impressive,” Shimmin said. He added that Google’s ultimate goal is to inculcate users into its overall platform because that’s where it makes money. Therefore, it must be consistent with AI Mode to entice enterprise business users.

    “Google is anticipating a higher quality and customer engagement with AI Mode,” he said. He added that users will engage more with AI Mode because of capabilities such as Deep Search, and the removal of sponsored ad content seen now at the top of traditional search in Google.

    Business calling and an unfilled gap

    Another capability that sets AI mode apart is the business calling function.

    “The new business calling feature is accelerating the path to agentic search and is a way for Google to get users to trust Google to act on their behalf,” Lai said. He added that while business calling currently only searches prices, he anticipates it will soon be able to shop on users’ behalf.

    “That’s really going to be the jack point for Google,” Lai said, referring to an inflection point. “This is a step in that direction of mitigating counterparty risks between merchants and consumers and getting consumers comfortable with Google acting on their behalf.”

    While Google has the expertise and legacy in search and is continually innovating with AI Mode, it still has some gaps that put OpenAI and Perplexity slightly ahead of the search giant in some areas.

    One area in which the search giant appears to lag is that it has yet to find a way to develop a shopping capability so that users can directly shop on Google, Lai said. Meanwhile, OpenAI has partnered with Shopify, which could put the GenAI vendor closer than ever to offering a shopping capability directly from ChatGPT.

    OpenAI is reportedly also working on a payment checkout system within the AI chatbot.

    Meanwhile, French AI startup Mistral introduced new features to its Le Chat chatbot on Thursday. The vendor introduced a deep research mode, which provides fast, structured research reports on complex topics, Mistral said. Le Chat users can also try Mistral’s new voice model, Voxtral, while editing images directly in Le Chat. Other new capabilities include multilingual reasoning and the ability to organize conversations.

    Esther Shittu is an Informa TechTarget news writer and podcast host covering AI software and systems.

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  • Google study shows LLMs abandon correct answers under pressure, threatening multi-turn AI systems · EMSNow

    Google study shows LLMs abandon correct answers under pressure, threatening multi-turn AI systems · EMSNow

    A new study by researchers at Google DeepMind and University College London reveals how large language models (LLMs) form, maintain and lose confidence in their answers. The findings reveal striking similarities between the cognitive biases of LLMs and humans, while also highlighting stark differences.

    The research reveals that LLMs can be overconfident in their own answers yet quickly lose that confidence and change their minds when presented with a counterargument, even if the counterargument is incorrect. Understanding the nuances of this behavior can have direct consequences on how you build LLM applications, especially conversational interfaces that span several turns.

    SOURCE: Venture Beat

    Testing confidence in LLMs

    A critical factor in the safe deployment of LLMs is that their answers are accompanied by a reliable sense of confidence (the probability that the model assigns to the answer token). While we know LLMs can produce these confidence scores, the extent to which they can use them to guide adaptive behavior is poorly characterized. There is also empirical evidence that LLMs can be overconfident in their initial answer but also be highly sensitive to criticism and quickly become underconfident in that same choice.

    To investigate this, the researchers developed a controlled experiment to test how LLMs update their confidence and decide whether to change their answers when presented with external advice. In the experiment, an “answering LLM” was first given a binary-choice question, such as identifying the correct latitude for a city from two options. After making its initial choice, the LLM was given advice from a fictitious “advice LLM.” This advice came with an explicit accuracy rating (e.g., “This advice LLM is 70% accurate”) and would either agree with, oppose, or stay neutral on the answering LLM’s initial choice. Finally, the answering LLM was asked to make its final choice.

    Example test of confidence in LLMs Source: arXiv

    A key part of the experiment was controlling whether the LLM’s own initial answer was visible to it during the second, final decision. In some cases, it was shown, and in others, it was hidden. This unique setup, impossible to replicate with human participants who can’t simply forget their prior choices, allowed the researchers to isolate how memory of a past decision influences current confidence.

    A baseline condition, where the initial answer was hidden and the advice was neutral, established how much an LLM’s answer might change simply due to random variance in the model’s processing. The analysis focused on how the LLM’s confidence in its original choice changed between the first and second turn, providing a clear picture of how initial belief, or prior, affects a “change of mind” in the model.

    Overconfidence and underconfidence

    The researchers first examined how the visibility of the LLM’s own answer affected its tendency to change its answer. They observed that when the model could see its initial answer, it showed a reduced tendency to switch, compared to when the answer was hidden. This finding points to a specific cognitive bias. As the paper notes, “This effect – the tendency to stick with one’s initial choice to a greater extent when that choice was visible (as opposed to hidden) during the contemplation of final choice – is closely related to a phenomenon described in the study of human decision making, a choice-supportive bias.”

    The study also confirmed that the models do integrate external advice. When faced with opposing advice, the LLM showed an increased tendency to change its mind, and a reduced tendency when the advice was supportive. “This finding demonstrates that the answering LLM appropriately integrates the direction of advice to modulate its change of mind rate,” the researchers write. However, they also discovered that the model is overly sensitive to contrary information and performs too large of a confidence update as a result.

    Sensitivity of LLMs to different settings in confidence testing Source: arXiv

    Interestingly, this behavior is contrary to the confirmation bias often seen in humans, where people favor information that confirms their existing beliefs. The researchers found that LLMs “overweight opposing rather than supportive advice, both when the initial answer of the model was visible and hidden from the model.” One possible explanation is that training techniques like reinforcement learning from human feedback (RLHF) may encourage models to be overly deferential to user input, a phenomenon known as sycophancy (which remains a challenge for AI labs).

    Implications for enterprise applications

    This study confirms that AI systems are not the purely logical agents they are often perceived to be. They exhibit their own set of biases, some resembling human cognitive errors and others unique to themselves, which can make their behavior unpredictable in human terms. For enterprise applications, this means that in an extended conversation between a human and an AI agent, the most recent information could have a disproportionate impact on the LLM’s reasoning (especially if it is contradictory to the model’s initial answer), potentially causing it to discard an initially correct answer.

    Fortunately, as the study also shows, we can manipulate an LLM’s memory to mitigate these unwanted biases in ways that are not possible with humans. Developers building multi-turn conversational agents can implement strategies to manage the AI’s context. For example, a long conversation can be periodically summarized, with key facts and decisions presented neutrally and stripped of which agent made which choice. This summary can then be used to initiate a new, condensed conversation, providing the model with a clean slate to reason from and helping to avoid the biases that can creep in during extended dialogues.

    As LLMs become more integrated into enterprise workflows, understanding the nuances of their decision-making processes is no longer optional. Following foundational research like this enables developers to anticipate and correct for these inherent biases, leading to applications that are not just more capable, but also more robust and reliable.

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  • Spy Shots Catch Newly-Announced BMW M2 Track Package Already Testing At Nürburgring

    Spy Shots Catch Newly-Announced BMW M2 Track Package Already Testing At Nürburgring

    Well, that didn’t take long. Just a few days after BMW M announced that a street-legal Track Package is being developed for the M2 coupe, spy shots of the pre-production prototype testing around the Nürburgring have already been snapped.


    bmw-logo

    Base Trim Engine

    3.0 twin-turbocharged straight-six

    Base Trim Transmission

    6-Speed Manual

    Base Trim Drivetrain

    Rear-Wheel Drive



    As the M2 Track Package isn’t due to be launched until 2026, official details are being kept under heavily camouflaged wraps. It’s not even clear whether these new components will be sold individually or as a complete Track Day Package. We do know, however, that this project is being overseen by BMW’s M Performance Parts accessories division. This “serious upgrade” will then probably include M Division-developed tweaks to the suspension, the aerodynamics, the cabin, and possibly the powertrain.

    Related

    BMW Is Taking The M2 Back To The Nurburgring

    BMW’s Street Legal M2 Racing scheduled for 2026

    M-Grade Aero And Suspension Upgrades Expected

    There are a few details we can glean from these spy shots. That new and enormous rear spoiler, for example, features a Swan Neck mount. This is a notable update over the conventionally-mounted carbon wing offered as part of the first Performance Package BMW launched for the G87 M2 three years ago. Why is that significant? Well, the Swan Neck is a more effective way to force airflow over the wing, and thus improves mid-corner stability.

    Also, in 2022, that carbon wing could be traded out for a tail-lip spoiler instead, an option BMW may well introduce for 2026 as well. The new and presumably carbon-fiber front splitter, meanwhile, appears noticeably closer to the track surface in these spy shots. This suggests that an adjustable M Performance suspension has been mounted to this M2 mule, lowering the ride height and dialing in racier handling in the process.

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    Is a BMW iX3 M already in the works?

    There are some significant differences between this camouflaged bodywork and BMW’s 2022 performance package, too. The side skirt and front bumper aero flicks are nowhere to be seen on the Sao Paulo Yellow panels, suggesting there are limited aero changes to the doors, the side sills and the roofline. The carbon side spats behind the front and rear wheels are also missing. The camouflaged front and rear fenders, meanwhile, could be hiding a wider and/or more muscular wheel arch design. This suggests that the multi-spoke, and presumably lighter-weight, alloys shown on BMW’s official teaser image will be wider than those on the stock M2 to help improve traction. Whether these CS-esque wheels also conceal larger M Performance brakes remains to be seen.

    Track Pack Unlikely To Feature Stripped-Out Cabin

    It’s highly unlikely that this street-legal track package will feature a stripped-out cabin. Take a look through the rear window, and you’ll notice the rear headrests are still there. More than likely, BMW M Performance Parts have instead opted for a more dynamic carbon fiber and Alcantara-upholstered cabin. In a bid to shed further weight, BMW may have taken inspiration from the F87 M2 Performance Edition, a zestier package that ripped out the dual-zone climate control and power seats, among other cabin comforts, to shed weight and improve maneuverability.

    Related

    The Best Modern BMW M Car Is Now Available For $50,000

    The best modern M car, offering a powerful inline-six paired with a manual transmission, can be had for roughly $50,000.

    Whether BMW has upgraded the M2’s 3.0-liter TwinTurbo straight-six also remains to be seen. Indeed, the Bavarian brand may wish to leave a 50-horsepower window between the stock, 473-horsepower M2 Coupe and the 523-hp M2 CS for future upgraded models. In that case, this new track package could emulate its Performance Parts forebears by raising the electronically limited 155-mph top speed. Hopefully more updates will follow in the coming weeks.

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