Author: admin

  • How to clean keyboard grunge, earwax in earphones and screen smudges

    How to clean keyboard grunge, earwax in earphones and screen smudges

    LONDON (AP) — Smartphones, laptops, headphones and other electronic devices are essential for work and play in our daily lives. But all that time spent typing, scrolling or listening also means our devices gradually accumulate grime that needs to be cleaned off.

    You might not give much thought to cleaning your devices but there are reasons you should, says Logitech, which makes keyboards, webcams and other computer peripherals.

    “Regular cleaning and proper maintenance not only keeps your gadgets looking pristine, and wins you hygiene points, it also helps them perform better and last longer,” the company says. “In the case of devices like earbuds, the accumulated bacteria and debris may even cause health issues or discomfort.”

    Here are some pointers on cleaning your tech:

    Getting started

    Always check if the manufacturer has any specific guidelines for cleaning.

    Assemble some basic equipment and material for cleaning, which should include a soft and lint-free cleaning cloth, like a microfiber cloth; cotton swabs; a soft-bristled brush like a toothbrush, paintbrush or makeup brush; compressed air and isopropyl alcohol.

    Isopropyl, or rubbing alcohol, is a non-toxic cleaning solvent that’s antiseptic and antibacterial. It’s popular for cleaning electronics because it doesn’t leave any residue and dries quickly. But you might want to wear gloves to avoid skin irritation. Drip some of it on a cloth instead of pouring it directly onto your device. Also heed some of the more specific warnings below.

    Water and mild soap can be useful for cleaning dirty surfaces, but isopropyl alcohol is recommended for cleaning the internals of a device, said Alex Diaz-Kokaisl, senior technical writer at electronics repair company iFixit.

    “While there isn’t a hard-and-fast rule for cleaning electronics, we generally use high-concentration isopropyl alcohol (more than 90%) because it evaporates quickly,” he said. “The faster a liquid evaporates, the less likely it is to affect any components that conduct electricity.”

    For whatever device you’re cleaning, disconnect or power it off first. Remove any cases, plugs, covers and accessories.

    Computers and laptops

    When using a computer, the keyboard and mouse are the parts that are touched most often and therefore need the most frequent cleaning. And all those crevices between a keyboard’s keys are sure to catch crumbs.

    To remove any loose debris, iFixit’s official in-house cleaning guide recommends using a can of compressed air. Run the spray back and forth across the keys to blow out any bits. If possible, hold the keyboard upside down so the debris falls out.

    If you don’t have compressed air, Logitech suggests using a hair dryer on the cold air setting. Some social media users also recommend a handheld balloon pump.

    Next, dampen a cleaning cloth with water and gently wipe down the keyboard and mouse.

    Logitech says you can also use rubbing alcohol but recommends you test it first on an inconspicuous spot to make sure it doesn’t cause discoloration or scrub the lettering off the keys.

    Anti-bacterial baby wipes can also work on devices like a mouse, Diaz-Kokaisl said.

    “There shouldn’t be enough liquid to seep through cracks in the shell, and their residue typically evaporates faster than just using soap and water,” he said.

    For laptop screens or external monitors, use a dry microfiber cloth to gently wipe away fingerprint smudges.

    If there are more stubborn spots — like food stains or sneezy spatters — dampen the cloth with distilled water or a 50/50 solution of distilled water and vinegar.

    Computer maker Lenovo says the “gentle acidity of vinegar can help break down oils and fingerprints.” Avoid using household glass cleaners, which can contain ammonia that could damage the screen. The same goes for paper towels, which can scratch the screen. HP also warns against using rubbing alcohol.

    AirPods and earphones

    A lot of people listen to music or podcasts through their earbuds, but that also means they’ll need regular cleaning to remove any earwax, natural skin oils or other grungy buildup.

    If the earbuds have silicon tips, remove them. Cleaning procedures vary depending on your brand and model. Logitech and Bose recommend using soapy water. But Sony warns against water or wet wipes because they can speed deterioration, and, instead, advises using a dry cloth.

    Use a cotton swab to wipe the earbud nozzles clean.

    Owners of Apple AirPods need to follow a much more elaborate procedure to clean the mesh. You’ll need a child’s toothbrush, two small cups, a paper towel, distilled water, as well as micellar water — typically used as a facial cleanser.

    Pour some micellar water into a cup, dip the toothbrush, brush the AirPod’s various mesh parts, and then blot them dry with the paper. Repeat twice. Then repeat that procedure but using the distilled water to rinse off the micellar water. Finally, let the AirPods dry for at least two hours.

    To clean the rest of the AirPod’s body, use a damp cloth. And don’t forget about the charging case. Apple recommends brushing out any debris and then wiping with a dry cloth. If needed, dampen it with isopropyl alcohol.

    What about over-the-ear headphones? Bose says you should wipe them down at least once a week, especially after working out, to remove any dirt and bacteria hiding in the nooks and crannies. Remove the pads and use a cloth dampened with soapy water to clean them.

    Smartphones

    Apple has issued specific instructions on its website for cleaning various iPhone models. Samsung has posted similar guidelines for its Galaxy lineup.

    They both advise using a soft, lint-free cloth, such as a lens cleaning cloth, to gently wipe the outside of the phone. Apple warns against using any cleaning products, which could erode the oil-repellent coating that most iPhones come with.

    Both companies say it’s OK to use disinfectants such as rubbing alcohol to gently clean the exterior, but avoid bleach or hydrogen peroxide.

    ___

    Is there a tech topic that you think needs explaining? Write to us at [email protected] with your suggestions for future editions of One Tech Tip.

    Kelvin Chan, The Associated Press


    Continue Reading

  • Palace takes urgent action as Harry, Meghan plans leak in privacy breach

    Palace takes urgent action as Harry, Meghan plans leak in privacy breach



    Palace takes urgent action as Harry, Meghan plans leak in privacy breach

    Tensions are running high at Buckingham Palace as the top aides of the monarch were grasping at straws to stop a major leak from happening.

    Three weeks ago, The Telegraph published a report in which Prince Harry and Meghan Markle were “at the heart of the King’s funeral plans”. The funeral plans of the monarch are code named as ‘London Bridge’.

    The story about the ‘bridge plans’ was leaked by someone insider the Palace and it led to the a “huge censorship operation” to “contain the spill”, according to The Daily Beast.

    New details reveal that the king’s most senior aide, Tobyn Andreae, “had a meltdown on the phone” to editors at the Telegraph, a reliably pro-monarchy publication, about its London Bridge story.

    “These new details about London Bridge, including that Harry and Meghan will be invited for central roles and that the mourning period will be shortened, had found their way to the Telegraph exclusively,” said a well-placed Fleet Street source.

    “There was a conversation with the palace’s communications team ahead of publication.”

    Tobyn “was very, very, unhappy” as tried to convince the outlet to change the timing of the article with the outlet but the editors were determined to stick to their editorial independence. The top aide believed that the story was “premature”.

    As the publication proceeded to publish the exclusive story, Tobyn, who met with the Sussexes top aides in an informal meeting in London last week, issued a warning to other newspapers about even quoting the Telegraph report.

    The King’s aide did not confirm the accuracy of the claims but vehemently denied that there was any active funeral planning underway for the monarch getting weekly cancer treatments.

    He noted in a series of WhatsApp messages, via The Daily Beast, that the report is “deeply distasteful in normal circumstances” but “downright offensive” given the King is doing well.

    Tobyn warned the outlets that “no matter how ‘sensitively framed’” the article is, the Palace will “not assist media with operational planning” if newspapers published “speculative pieces about Bridges planning, whatever the source”.

    The update comes after Tobyn was seen meeting the Duke of Sussex’s chief of staff and communications director, Meredith Maines, and the Sussexes’s U.K. spokesperson, Liam Maguire, at a London’s private club near Clarence House.

    It is possible that the summit had been to discuss the security breach and how to deal with the new piece of information. Although, speculations of a reunion began after the meeting given that the monarch and his younger son have not been speaking since more than a year.

    It remains to be seen how the events will unfold over the next few weeks until Harry touches down in London in September.

    Continue Reading

  • Study Reveals New Clues in Liver Disease Prevention | Newsroom

    Study Reveals New Clues in Liver Disease Prevention | Newsroom

    The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to a study led by investigators at Weill Cornell Medicine. The findings suggest the possibility of future therapies that would block or reduce such changes to treat or prevent age-related chronic liver diseases—effectively making the liver more youthful and resilient.

    In the study, published on July 4 in Hepatology, the researchers compared gene activity and other features of the cells in aged versus young mouse livers. Among the major aging-related changes they observed were enlargements of many liver cells, inflammation and blurring of the functional zones of normal livers. The researchers observed similar changes when comparing older and younger human livers.

    “Do these changes underlie the aging liver’s reduced ability to metabolize drugs, neutralize toxins and resist liver disease?” said study senior author Dr. Robert Schwartz, an associate professor of medicine and the Irma Hirschl Trust Research Award Scholar at Weill Cornell Medicine and a hepatologist at NewYork-Presbyterian/Weill Cornell Medical Center. “That’s the big question we now intend to investigate.”

    Dr. Robert Schwartz

    The liver’s essential functions include filtering the blood and storing metabolites and nutrients. It does have the ability to regenerate itself, which has encouraged the view that it is less affected by aging than other organs. But chronic liver diseases, especially metabolic dysfunction-associated steatotic liver disease (MASLD), are more likely to develop as people age, and in general are extremely common—one recent study suggested that the condition affects 30 to 40 percent of the U.S. population. MASLD also can develop into severe, inflammatory forms leading to cirrhosis and cancer. Yet the molecular underpinnings of such age-related liver conditions are poorly understood.

    In the study, Dr. Schwartz’s team used a variety of tools to take a fresh look at the differences between aged and young livers. While the livers of two-year- and two-month-aged mice were similar in weight and overall appearance, comparison under a microscope showed that the cells in aged livers were much larger on average, with marked deposits of lipofuscin, a substance known to accumulate in, and potentially damage, aging cells.

    Some of the most striking findings came from single-nucleus RNA sequencing, a relatively new method that allows scientists to profile gene activity in essentially all cell types in a tissue sample. This study is thought to be the first that applies the technique to understand liver aging. The resulting dataset on gene activity in tens of thousands of liver cells revealed that aging has a strong impact on the usual functional organization or “zonation” of hepatocytes, the main type of liver cell.

    “In young, healthy livers, hepatocytes perform distinct functions in distinct zones in the liver with different proximities to blood supply, but in aged livers this zonation is lost,” said study first author Dr. Saloni Sinha, a postdoctoral research associate in the Schwartz laboratory. “We suspect this impairs the liver’s functions and its ability to respond to stress or injury.”

    The RNA sequencing showed that there are significant aging-related differences in the activity levels of hundreds of genes in dozens of distinct liver cell types. Analyses of these differences pointed, among other things, to higher levels of inflammation and the non-dividing, pro-inflammatory cell state known as senescence. Scientists in recent years have come to see the accumulation of senescent cells and associated inflammation—“inflammaging”—as a major driver of tissue aging and disease susceptibility.

    The researchers confirmed the likely relevance of their mouse findings to human biology with similar findings in biopsies of livers from younger and older people.

    The data generated in the study represent a significant new resource for scientists who study liver biology. Dr. Schwartz, who is also a member of the Weill Cornell Medicine Sandra and Edward Meyer Cancer Center, and Dr. Sinha hope it will lead them to new strategies for keeping aged livers younger and healthier.

    Many Weill Cornell Medicine physicians and scientists maintain relationships and collaborate with external organizations to foster scientific innovation and provide expert guidance. The institution makes these disclosures public to ensure transparency. For this information, see profile for Dr. Robert Schwartz.

    This research was supported in part by grants from the National Cancer Institute, the National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases, all part of the National Institutes of Health, through grant numbers R01CA234614, R01AI107301 and R01DK121072. Additional support was provided by the department of Defense through grant number W81XWH-21-1-0978, and from The Paul G. Allen Family Foundation UWSC13448.

    Continue Reading

  • England Men U19s squad announced for Second Youth Test

    England Men U19s squad announced for Second Youth Test

     

    England have announced their squad for the second U19s Youth Test match against India set to be played at the Ambassador Cruise Line Ground.

    Tickets and Hospitality are on sale for the four-day Second Youth Test Match which will begin in Chelmsford on Sunday 20 July.

    A 14-player squad has been selected for the second Youth Test which begins on Sunday at Chelmsford, with Will Bennison, Ben Dawkins, Joe Hawkins, and Adam Thomas being added.

    England U19s Men Youth Test squad:

    Thomas Rew (Somerset – captain)
    Ralphie Albert (Surrey)
    Will Bennison (Yorkshire)
    Ben Dawkins (Kent)
    Rocky Flintoff (Lancashire)
    Alex French (Surrey)
    Alex Green (Leicestershire)
    Joe Hawkins (Derbyshire)
    Jack Home (Worcestershire)
    Ben Mayes (Hampshire)
    James Minto (Durham)
    Aaryan Sawant (Middlesex)
    Jay Singh (Yorkshire)
    Adam Thomas (Surrey).

    India have also named their squad which includes 14-year old IPL sensation, Viabhav Suryavanshi, who has already made a big impression during the tour, smashing a 78-ball 143 during the one-day series at Worcester.

    India U19s Men Youth Test squad:

    Ayush Mhatre (captain)
    Vaibhav Suryavanshi
    Vihaan Malhotra
    Maulyarajsinh Chavda
    Rahul Kumar
    Abhigyan Kundu (Vice-Captain & WK)
    Harvansh Singh (WK)
    R S Ambrish
    Kanishk Chouhan
    Khilan Patel
    Henil Patel
    Yudhajit Guha
    Pranav Raghavendra
    Mohammed Enaan
    Aditya Rana
    Anmoljeet Singh

    Tickets

    Tickets are now on sale for all four days of the match via the Essex Cricket website. Don’t forget, the game is FREE to attend for all Essex Cricket 2025 Members. Simply show your Membership Card to gain entry.

    Members: Free

    Adults: £10

    Student/Young Adults (18-25): £10

    Junior (U18): £3


    Hospitality

    Hospitality is also available for the first three scheduled days of the match, starting from £54 per person and includes your match ticket.


     
    Head to the Seat Unique website to book your hospitality by clicking the button below or alternatively, please call Julie Ager on 01245 254063.

     


    Continue Reading

  • Bryan Mbeumo: Manchester United make £70m bid for Brentford forward

    Bryan Mbeumo: Manchester United make £70m bid for Brentford forward

    Although United have been strongly linked with Chelsea forward Nicolas Jackson and Aston Villa goalkeeper Emiliano Martinez in recent days, it has always been the priority at Old Trafford to get the Mbeumo deal done in time for Amorim to work with him in the Chicago, where United will largely be based for their 13-day trip.

    The 25-year-old scored 20 Premier League goals last season and a number of clubs were interested in him, including Tottenham, now managed by former Brentford boss Thomas Frank.

    However, Mbeumo’s preference was to join United.

    Brentford’s other main goal threat, striker Yoane Wissa, is the subject of interest from Newcastle.

    Last season Amorim repeatedly spoke about United’s failure to convert their chances.

    Their 44 Premier League goals was their worst return in a domestic campaign since they were relegated in 1973-74.

    United have signed forward Matheus Cunha and defender Diego Leon in the summer transfer window.

    Continue Reading

  • Why Android-Makers Should Focus on the Phone and Leave AI to Google

    Why Android-Makers Should Focus on the Phone and Leave AI to Google

    If you’ve bought an Android phone in the past year, you’ve likely noticed that it’s packed with AI features. Maybe you knew about them before you hit purchase, maybe you assumed (safely as it turns out) that there would be some kind of AI on your new phone, or maybe they took you totally by surprise.

    If you bought a Samsung Galaxy S25, for example, you’ll have had Gemini, Circle to Search, Bixby and Galaxy AI at your fingertips — all before you even thought about downloading the ChatGPT app. It reminds me of the early days of Android, when phone-makers tried to load devices with their own apps, services and overwrought UIs in the name of differentiation. Which sparks the question: Is AI the new Android bloatware?

    It’s easy to understand why Android phone-makers have latched onto the idea that AI might be a useful tool to set them apart from rivals. After all, most flagship Android phones share the same DNA: a high-end processor (usually the top Snapdragon chip from Qualcomm), the latest Android software, a competitive camera system and a battery that will last for a day or more. The truth is that we’re often splitting hairs when trying to recommend one over another.

    When generative AI arrived on the scene, offering the potential to bring new experiences to mobile devices, Android phone-makers were keen to tap into those possibilities. Here was a new opportunity to differentiate themselves, and give people a fresh reason to choose them over a competitor. (And over the iPhone, as Apple slow-walks Apple Intelligence into being.) 

    In reality, it’s not quite playing out that way — and for a few different reasons. First, research conducted by CNET and supported by the findings of independent industry analysts consistently shows us that people aren’t upgrading their phones due to the availability of AI features. Instead, the things they care about, in order of importance are price, longer battery life, storage, cameras. In other words, the same exact things they’ve prioritized for years when choosing a new phone.

    The second issue is that in spite of some manufacturers’ best efforts, AI isn’t the differentiator they thought it would be. At the heart of this problem is that there’s barely an Android phone hitting the market right now that doesn’t already have the most cutting-edge tech built into it thanks to Google Gemini. Every Android phone maker has its own flavor of AI, but more often than not, this means a bunch of gimmicky features added onto the existing software in a haphazard fashion, creating something of a Frankenstein effect.

    Early-mover advantage: Galaxy AI

    Of all the Android phone-makers trying to make their own AI brand stick in our minds, it’s perhaps Samsung that’s in with the best chance. Compared to rivals, it was relatively early to jump onto the AI bandwagon, launching Galaxy AI in January 2024, giving it a strategic headstart that it’s built on ever since.

    Last week it followed the launch of its latest foldables with an AI forum, during which it revealed that 70% of Galaxy S25 owners were using Galaxy AI features. More than half, it added, were using Circle to Search. This year it will bring Galaxy AI to more than 400 million devices.

    a screenshot from Samsung showing Android's Circle to Search feature

    Android’s Circle to Search feature originally launched on Samsung Galaxy S24 and Pixel 8 phones in January 2024.

    Samsung/Screenshot by CNET

    This all sounds positive, until you remember that Circle to Search is a Google feature, not a Samsung feature. Google, which makes the Android OS, often hands out temporary exclusives to Android phone-makers on new Gemini features, as it initially did with Circle to Search for Samsung in 2024. It did it again this year with an image-to-video generator, which debuted with Honor. 

    It’s surely a nice sweetener for Google’s relationships with phone-makers to be able to offer them these exclusives. But most of the standalone AI mobile tools we’ve seen grab the headlines are ultimately Gemini features made by Google, not the work of individual phone-makers, and it’s only a matter of time before they become available on other Android devices – including Google’s own Pixel phones.

    To Google, “nothing is more important than Gemini,” said Ben Wood, chief analyst at CCS Insight. It is a “strategic pillar of the future of Google.” And how better, he adds, to ensure its success than getting it into people’s hands through the 3 billion Android phones in the marketplace (which puts Samsung’s 400 million into perspective)?

    Samsung might have the largest market share of any Android phone maker, but when you look at its reach compared to Google’s, it’s clear that Galaxy AI, which sits on top of Gemini, is at a competitive disadvantage.

    Bonus AI

    Of course Samsung and other Android phone-makers will say their own flavors of AI don’t compete with Gemini, but complement it. And there is some validity in this idea. 

    It’s rare that a phone maker attempts to replicate something Google has already done. Instead they look for opportunities to add their own AI twist — often in the form of camera features. But whether they do this well enough for it to make any kind of meaningful impact on people’s decisions to buy their phones is another question entirely.

    This week, OnePlus began rolling out its own suite of AI features, announced back in May, to the OnePlus 13 and 13R. These include some photo tools and an AI content hub called Plus Mind to act as your memory for important information.

    img-6525

    OnePlus’ natural language search within “Mind Space” worked well for me.

    Katie Collins/CNET

    It would be a waste of time for OnePlus to replicate features in house that have already been developed by Google, said Arthur Lam in an interview at the software launch. A central part of the company’s AI strategy is to “embrace and integrate [Google AI features] as fast as possible,” he said.

    “At the same time, we should have our own proposition, our own idea about what OnePlus AI should stand for,” added Lam. 

    This is where Plus Mind comes in. It’s an interesting first step from the company, although perhaps not quite as compelling as a company such as Motorola, which is investing in a LAM (large action model) — as opposed to an LLM, or large language model — that will respond to questions with actions, not just words. The idea is that it will use its understanding of your environment and reduce the number of interactions you need to have with your phone to order a coffee or an Uber, for example.

    All roads lead to Gemini

    As for Google, the company thinks it’s “great” that phone makers are developing their own AI to complement the suite of tools it’s providing them. That’s what Sameer Samat, president of Android, told Tech Radar this week.

    “If the features are great, it’s more value for the consumers and more innovation,” he said. “But I think for us, as Google, we want to make sure those two pieces [Circle to Search and Gemini] are very clearly accessible, very clearly identifiable across all the different devices that consumers are considering.”

    It’s a revealing statement from Samat, supporting the theory that Google’s ambition is to be the final boss of the AI smartphone experience. As Wood puts it: “All roads lead to Gemini.”

    Ultimately, it’s not only Google’s reach that is going to allow Gemini to be the dominant AI tool on Android phones, but the budget and talent the company has to dedicate to AI, which individual phone-makers just can’t match.

    This means that when it comes to differentiation, AI is unlikely to be the factor that sets brands such as Samsung and OnePlus apart. “Handset manufacturers are in danger of being left to compete more on brand and industrial design than AI features and capabilities,” said Wood.

    True differentiation: The Nothing story

    One company that seems to have realized this is UK-based Nothing. Over the past year or so, I’ve attended, either in person or virtually, almost every major Android phone launch. One thing most of them have in common is a Google representative on stage espousing the many benefits of Gemini.

    At the launch of the Nothing Phone 3 in London earlier this month, the company bucked this trend. Nothing still has a tiny market share — around 0.2% as estimated by founder and CEO Carl Pei. But since its inception in 2022, it’s managed to thrive and grow in a competitive, mature phone marketplace thanks largely due to its focus on design.

    nothing-phone-3-lanxon-review-01

    Nothing’s focus on design sets it apart.

    Andrew Lanxon/CNET

    That’s not to say it’s ignored AI, but it has taken a different approach. Earlier this year it launched “Essential Space,” an AI-powered portal for storing and organizing everything important on your phone, from screenshots to calendar invites. It was a unique feature that’s already been effectively copied by some other phone-makers (see OnePlus’ efforts above).

    Nothing does use Gemini, but it’s not reliant on it in the same way its competitors are. “We don’t want to do the model side,” Pei explained to me at its Phone 3 launch earlier this month. “There’s companies that are really good at it. They’re very well funded and they’re all competing against each other.”

    Instead, Nothing has built its AI platform to be “model agnostic,” he said. “When the models get better, we just switch to the best one. Right now, I think it’s powered by Gemini, but there’s no stopping us from changing to the latest and greatest.”

    The uphill battle ahead

    A flexible approach to AI seems like the safest bet at this time when the technology is changing minute by minute. It’ll be an uphill battle for Android phone-makers to keep up, and hope their own efforts will remain relevant and prove useful as Google charges ahead offering best-in-class mobile AI experiences.

    The real fight here is the same one we’ve seen play out for the past decade and a half: It’s Apple versus Google. The true differentiation we’re seeing in mobile AI right now is between Google Gemini and Apple Intelligence, with the former leading the field and the latter trailing in its wake.

    For as long as Google attempts to aggressively build upon its early AI lead while holding the Android ecosystem in the palm of its hand, phone-makers will need to do more than just rely on AI to persuade us that their Android offering truly is the best of the best.


    Continue Reading

  • New Study Explores Oral Vancomycin to Prevent C difficile Recurrence, But Questions Remain

    New Study Explores Oral Vancomycin to Prevent C difficile Recurrence, But Questions Remain

    Realistic electron microscopy of Clostridioides difficile, highly detailed rod-shaped structure, spores with textured surfaces, flagella, acid-green and purple hues, contrasting black background.

    (Adobe Stock 1318793046 by Waseem by AI)

    A new randomized clinical trial published this month in JAMA Network Open sheds light on the use of oral vancomycin to prevent recurrent Clostridioides difficile infection (CDI) in patients taking antibiotics for reasons unrelated to CDI. While the findings suggest a trend toward reduced recurrence, the study was ultimately underpowered, leaving important questions about the effectiveness and risks of this approach.

    CDI remains the most common cause of health care-associated diarrhea, and recurrence is a significant concern. More than one-third of patients experience at least 1 repeat episode after an initial infection, with risk increasing further with each recurrence. Antibiotic exposure, even for conditions unrelated to CDI, is a primary trigger, disrupting the gut microbiome and allowing C difficile to flourish again. This creates an urgent need for effective strategies to prevent recurrence, especially when patients must take antibiotics for other infections.

    This new trial sought to test whether a daily low dose of oral vancomycin could prevent recurrent CDI in such high-risk patients. Conducted across 4 major health systems in the Midwest from 2018 to 2023, the study enrolled adults who had recovered from CDI within the previous 6 months and were beginning a short course of antibiotics for another condition. Participants were randomized to receive either 125 mg of oral vancomycin or a placebo once daily throughout their antibiotic course and for five days afterward.

    “In this randomized clinical trial, the incidence of recurrent CDI was lower (though did not reach significance) in participants taking oral vancomycin compared with those taking placebo,” the authors wrote. “Because the study was underpowered, it was unable to reveal firm conclusions about the efficacy (or lack thereof) of vancomycin prophylaxis with respect to recurrent CDI.”

    Ultimately, 81 participants were randomized: 39 to vancomycin and 42 to placebo. They were closely monitored for eight weeks after completing treatment. The study found that 43.6% of patients in the vancomycin group experienced a recurrence, compared to 57.1% in the placebo group. Although this suggested a possible protective effect, the difference was not statistically significant, highlighting the challenges of drawing firm conclusions from a study with fewer participants than initially planned.

    Beyond recurrence rates, the researchers also examined the impact on vancomycin-resistant Enterococcus (VRE), a concerning consequence of antibiotic use. By the end of the follow-up period, 50% of patients taking vancomycin showed VRE colonization, compared to only 24% in the placebo group 8 weeks after treatment. This points to a potential downside of using oral vancomycin prophylactically, as it may contribute to the spread of antibiotic-resistant organisms.

    Additionally, the authors wrote, “Adverse events occurred in 27 of 39 participants in the oral vancomycin group (69.2%) and 27 of 42 in the placebo group (64.3%).”

    These findings add to a complex and sometimes conflicting body of evidence. Previous retrospective studies and smaller trials have suggested that oral vancomycin may help reduce the likelihood of CDI recurrence when patients take additional antibiotics. However, data have been limited, with varying dosages, study designs, and patient populations. Some studies also noted that while vancomycin might temporarily suppress C difficile, many patients began shedding the organism again within weeks of stopping treatment, raising concerns about the durability of any protective effect.

    Guidelines reflect this uncertainty. While the American College of Gastroenterology has offered a conditional recommendation for oral vancomycin prophylaxis in patients at high risk for recurrence, it acknowledges the low quality of available evidence. Other leading groups, including the Infectious Diseases Society of America and European infectious disease societies, have either not endorsed routine prophylaxis or have suggested it only for carefully selected patients.

    This latest trial followed a rigorous double-blind, placebo-controlled design, making it one of the more robust efforts to explore this question. Yet enrollment challenges, including patients already taking vancomycin outside the study and disruptions from the COVID-19 pandemic, limited its statistical power. As a result, while trends favored fewer recurrences in the vancomycin group, the study could not definitively establish that the intervention worked better than placebo.

    Importantly, the increased detection of VRE in patients taking oral vancomycin underscores the trade-offs involved. While preventing CDI is critical, fostering resistant organisms carries its own serious risks for both individual patients and broader public health.

    In the end, this study highlights the urgent need for more research into effective ways to prevent recurrent CDI, especially during subsequent antibiotic exposures. It also serves as a caution that interventions like oral vancomycin prophylaxis should be carefully weighed against their potential to drive antibiotic resistance.

    For now, clinicians and patients must continue to navigate these complex decisions using the best available evidence, individualized risk assessments, and an understanding of both the benefits and downsides of prophylactic strategies. As the search continues for reliable methods to prevent recurrent CDI, studies like this provide essential insights to guide clinical practice and future investigations.

    Continue Reading

  • EV Anti-Involution Drives Gains As Biotech Breaks Out

    EV Anti-Involution Drives Gains As Biotech Breaks Out

    Key News

    Asian equities had a good day as Thailand, Indonesia, and Pakistan outperformed, while India posted a small loss.

    Hong Kong bounced around the room, while Shanghai and Shenzhen grinded higher, going from the lower left to the upper right.

    It was a fairly quiet night, as Premier Li and the State Council’s meeting on “strengthening the domestic big cycle” and limiting EV price wars, i.e. ”anti-involution”, were front page news. The implications of the government curtailing “overcapacity” in the auto, steel, cement, E-Commerce, and solar industries are significant for corporate balance sheets, ending domestic deflation, and China not exporting deflation.

    Li Auto gained +9.73% after announcing that a new model is open for pre-sales, as Geely Auto gained +4.16%, BYD gained +1.06%, XPeng gained +1.14%, though Xiaomi fell -2.01% and CATL fell -0.27%.

    Biotech stocks in both Hong Kong and Mainland China continued to outperform overnight, as Akeso gained +10.71% after starting Phase 3 trials for a metastatic colorectal cancer treatment. The space continues to benefit from drug releases, distribution deals, and favorable policy support. BeOne, formerly known as Beigene, gained +10.6%, Jiangsu Hengrui gained +2.06%, Sino Biopharmaceutical gained +5.9%, CSPC Pharma gained +3.58%, and WuXi Apptec gained +2.42%.

    Internet names were mixed, as Alibaba fell -1.14%, Meituan gained +1.13%, JD.com fell -0.16%, Trip.com fell -0.88%, Kuaishou fell -0.65%, and Tencent Music Entertainment gained +1.78%. South China Morning Post had an article about Meituan complaining about “irrational competition” from Alibaba and JD.com after the latter’s entrance into the restaurant delivery space sparked a price war. Another Chinese city announced local plans to curb the price war.

    Mainland investors bought $236 million worth of Hong Kong-listed stocks and ETFs via Southbound Stock Connect, though Tencent, which gained +0.10% overnight, remains a funding source and was sold by Mainland investors. Hong Kong and Mainland China-listed electronic equipment makers, software, and semiconductor stocks had very strong days. Nvidia’s Jensen Huang’s China trip and comments on chip sale approvals and the quality of Chinese electric vehicles (EVs) and AI garnered significant attention.

    According to the China Association of Automobile Manufacturers (CAAM), China’s auto exports increased +10.4% year-over-year (YoY) to 3.07 million in June.

    After the close, the Ministry of Finance (MoF) adjusted the tax rate on ultra-luxury cars with price tags above RMB 900,000 and canceled taxes on used vehicles.

    China and Australia singed a memorandum of understanding (MOU) to review the China-Australia Free Trade Agreement following Prime Minister Anthony Albanese’s six-day trip to China. There was also more media chatter of US-China trade deal percolating.

    Live Webinar

    Join us on Tuesday, July 22, 10:00 am EDT for:

    China Mid-Year Outlook: Trade Deal Loading, Consumption & Innovation Locked In

    Please click here to register

    New Content

    Read our latest article:

    KraneShares KOID ETF: Humanoid Robot Rings Nasdaq Opening Bell

    Please click here to read

    Last Night’s Performance

    Last Night’s Exchange Rates, Prices, & Yields

    • CNY per USD 7.18 versus 7.17 yesterday
    • CNY per EUR 8.31 versus 8.34 yesterday
    • Yield on 10-Year Government Bond 1.66% versus 1.66% yesterday
    • Yield on 10-Year China Development Bank Bond 1.72% versus 1.72% yesterday
    • Copper Price -0.08%
    • Steel Price +0.51%

    Continue Reading

  • Older adults and AI: U-M poll suggests a wary welcome – University of Michigan News

    1. Older adults and AI: U-M poll suggests a wary welcome  University of Michigan News
    2. Older Adults and AI: Poll Suggests a Wary Welcome | Newswise  Newswise
    3. Senior Issues: AI poised to make seniors’ lives better — like it or not  Traverse City Record-Eagle
    4. Watchful AI  Florida Trend
    5. The uncharted waters of AI  McKnight’s Senior Living

    Continue Reading

  • Emerging DJs Declan Knapp and Baobei (宝贝) win the chance to perform at Radio 1 Dance Weekend Ibiza 2025

    Emerging DJs Declan Knapp and Baobei (宝贝) win the chance to perform at Radio 1 Dance Weekend Ibiza 2025

    Emerging DJs Declan Knapp and Baobei (宝贝) have won the opportunity of a lifetime to play on the iconic island of Ibiza by opening Radio 1 Dance Weekend 2025 on Friday 1 August at 528 Ibiza. Every year, Radio 1 Dance partners with BBC Introducing to search for the UK’s very best and undiscovered DJs who produce their own music.

    Jaguar will host a special show tonight (Thursday 17 July) from 10pm on BBC Introducing on Radio 1 Dance where she will play tracks from both winners.

    The entries to Radio 1 Dance and BBC Introducing’s nationwide talent search were reviewed by BBC Introducing’s network of local and regional shows with each show forwarding one entry to the final shortlist and a panel of Radio 1 DJs and producers selecting the two winners.

    Declan Knapp is known for his high-energy blend of house, garage, and bass with emotive, euphoric builds. His official edit of Groove Armada’s ‘Superstylin’ landed its first radio play on Danny Howard’s Radio 1 Dance Party and earned support from Martin Garrix, Pete Tong, and Hannah Wants. Declan’s music has been played on Jaguar and Jess Iszatt’s Introducing shows, Radio 1’s Rave-Up with Arielle Free, Radio 1’s Future Dance with Sarah Story, and Radio 1’s Dance Anthems with Connor Coates.

    Declan Knapp says: “BBC Radio 1 has been a big part of my journey, so being invited to play their Ibiza weekend is something I’m really proud of. I’ve spent years crafting my sound and sets and now I get to bring that to one of the most iconic places in dance music. Expect a lot of energy and some proper moments.”

    Baobei (宝贝) is a London-born, British-Chinese DJ, producer and songwriter who blends next gen UK Garage and house with pure pop sensibilities. In January this year, Baobei’s track ‘Hugging My Friends’ was BBC Introducing’s Tune Of The Week and secured radio support from Danny Howard, Greg James, Radio 1’s Future Dance with Sarah Story, Jaguar on BBC Introducing on Radio 1 Dance, Jess Iszatt’s Introducing show, and Radio 1’s Chillest Show with Sian Eleri.

    Baobei says: “I am so looking forward to DJing for Radio 1 Dance Weekend and experiencing Ibiza club culture for the first time which I’ve heard so much about! I’m very grateful for the continued support from BBC Radio 1 and Introducing throughout my music journey. I am excited to play a fun set and add to Baobei lore!”

    They join a stellar line-up of some of the biggest names in Dance music including newly added Brazilian dance sensation, Alok, Ukrainian DJ, Miss Monique, and British DJ, TSHA. The full line-up for Radio 1 Dance Weekend Ibiza 2025 is (in alphabetical order):

    • Alok
    • Biscits
    • Chloé Caillet
    • Chris Lake
    • Coco & Breezy
    • Disciples
    • Emily Nash
    • Jess Bays
    • Special Guest b3b Special Guest b3b Locky
    • Miss Monique
    • Olive F
    • Sonny Fodera
    • TSHA
    • Zerb

    In addition to Radio 1’s epic dance event, the celebrations will continue throughout the weekend with Radio 1 Dance X at the following club across the island

    Radio 1 Dance X Afterparty at Amnesia Ibiza – Friday 1 August

    Line Up: Josh Baker, B2B Kettama, Caal, Chloe Callet, Danny Howard, Sarah Story

    ANTS at Ushuaïa Ibiza – Saturday 2 August

    Line-up: Djammin, Franky Rizardo B2b Cloonee, Jaguar, John Summit, Max Styler, Pete Tong

    elrow at [UNVRS] Ibiza – Saturday 2 August

    Line-up: Arielle Free, George Privati, Hugel, Matroda

    Glitterbox at Hï Ibiza – Sunday 3 August

    Line-up: Dan Shake B2b Myd, Dj Minx, Sophie Lloyd, Eli Escobar, Floorplan, Rich Medina, Joshua Lang, Mike Dunn

    Ibiza Rocks – Monday 4 August

    Line-up: Fish56Octagon, lau.ra, Connor Coates, Patrick Nazemi, Ibiza Rocks Resident DJs

    Tickets for Radio 1 Dance Weekend: Ibiza 2025 are currently on sale. Find more information on the Radio 1 Dance Weekend website.

    For those listening at home, the celebrations will kick off on Thursday 31 July in Radio 1 Dance Party Warmup with Danny Howard (Thursday, 6pm – 8pm) and will continue throughout the weekend with the station playing a mammoth eighty hours of Dance music. As well as this, Radio 1 Dance Weekend 2025 will broadcast live from Radio 1’s Main Stage on Friday 1 August, and from Radio 1’s Dance Stage on 2 August. Listeners will be able to tune in across the weekend on Radio 1 and Radio 1 Dance with performances and tracks available live and on demand across BBC Sounds and BBC iPlayer.

    EC2

    Follow for more

    Continue Reading