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  • Pakistan, Russia agree to enhance ties in trade, energy, defence sectors – Pakistan

    Pakistan, Russia agree to enhance ties in trade, energy, defence sectors – Pakistan

    Pakistan and Russia have agreed to further enhance cooperation in trade, energy, agriculture and defence sectors.

    This understanding came at a meeting between Deputy Prime Minister and Foreign Minister Ishaq Dar and Russian Foreign Minister Sergei Lavrov on the sidelines of the SCO Council of Foreign Ministers meeting in Tianjin, China.

    During the meeting, both the dignitaries expressed satisfaction over the positive trajectory of bilateral ties, DPM’s Office said.

    On this occasion, the foreign minister reiterated the invitation for FM Lavrov to visit Pakistan.

    FM Dar met Chinese President Xi Jinping as well at the Great Hall of the People in Beijing and conveyed him the warm greetings of the leadership, government and people of Pakistan.

    “As iron-clad brothers and all-weather strategic cooperative partners, we remain committed to deepening Pak-China enduring friendship and advancing shared regional goals,” Dar wrote in a post on X. The meeting between the foreign minister and Chinese president was held on the sidelines of the Shanghai Cooperation Organization (SCO) Council of Foreign Ministers meeting.

    Meanwhile, Foreign Minister Dar also represented Pakistan at the joint call of the Foreign Ministers of the SCO Member States on President Xi. The Chinese president, welcoming the heads of delegations, underlined the salience of regional cooperation under the ambit of SCO, an organisation covering the Eurasian land mass and a large expanse of the world’s population, Radio Pakistan reported.

    Senator Dar arrived in Beijing, China, on Monday to attend a three-day meeting of the SCO Council of Foreign Ministers being held in Tianjin, China. He is attending the event at the invitation of Foreign Minister of China Wang Yi.

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  • Israel must stop killings and home demolitions in occupied West Bank – ReliefWeb

    1. Israel must stop killings and home demolitions in occupied West Bank  ReliefWeb
    2. Attacks against Palestinians intensify in occupied West Bank: UN  Dawn
    3. Attacks on Palestinians intensifying in occupied West Bank: UN rights body  Al Jazeera
    4. After settlers uproot another Palestinian hamlet, activists aim ire at political powers  The Times of Israel
    5. Cartography of Israeli Apartheid: Gaza and the West Bank, two fronts of dispossession  Middle East Monitor

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  • OpenAI's ChatGPT-powered browser is codenamed 'Aura' – BleepingComputer

    1. OpenAI’s ChatGPT-powered browser is codenamed ‘Aura’  BleepingComputer
    2. Exclusive: OpenAI to release web browser in challenge to Google Chrome  Reuters
    3. Perplexity launches Comet, an AI-powered web browser  TechCrunch
    4. Google strengthens position as Perplexity and OpenAI launch browsers  Digital Watch Observatory
    5. AI Browsers : The Future of Productivity or Privacy Nightmare?  Geeky Gadgets

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  • Microplastics found to trigger cancer-linked changes in lung cells

    Microplastics found to trigger cancer-linked changes in lung cells

    Although the respiratory system is one of the main entry points for microplastics and nanoplastics (MNPs) from the air into the body, little is known about the effects of these tiny particles on the lungs. Researchers at MedUni Vienna have now demonstrated for the first time that MNPs can trigger malignant changes in lung cells that are associated with the development of cancer. The findings were published in the Journal of Hazardous Materials and once again underline the urgent need for action to reduce plastic waste.

    As part of the study, the research team led by Karin Schelch, Balazs Döme and Büsra Ernhofer (all from the Department of Thoracic Surgery and the Comprehensive Cancer Centre at MedUni Vienna) investigated how polystyrene micro- and nanoplastics (PS-MNPs) interact with different types of lung cells. Polystyrene is a plastic widely used in everyday objects, including food packaging and disposable items such as yoghurt pots and coffee-to-go cups. The surprising result of the research: healthy (non-malignant) lung cells absorb particularly small particles (0.00025 millimetres) of PS-MNPs significantly more than malignant cancer cells – and react with biological changes that once again highlight the health risks posed by MNPs.

    Specifically, after contact with the particles, the healthy cells showed increased cell migration, DNA damage, oxidative stress and the activation of signalling pathways that promote cell growth and survival – all processes that are considered early indicators of cancer development. “Particularly striking was the reduced ability of healthy cells to repair DNA damage and the simultaneous activation of certain signalling pathways that normally promote cell growth,” said study leader Karin Schelch, providing details.

    Long-term effects still unclear

    While lung cancer cells remained relatively unaffected under the same conditions, even short-term exposure to MNPs could be enough to influence healthy lung cells in a direction associated with malignant changes. According to the latest research findings, the cells’ defence mechanisms were also triggered under the influence of polystyrene particles. “We observed the activation of antioxidant defence systems – an indication that the cells are actively defending themselves against the stress caused by plastic particles,” explains first author Büsra Ernhofer.

    The lungs are considered one of the main routes of exposure to airborne microplastics. However, little was known about how these particles interact with lung tissue cells.

    The data now available provide initial indications that healthy lung cells in particular react in a way that gives cause for concern.”


    Balazs Döme, co-study leader

    This opens up new questions about the possible link between plastic pollution, chronic lung disease and cancer development – and underscores both the need for interdisciplinary research at the interface between environmental medicine and cancer biology and the need for action to reduce plastic waste. In addition, the long-term effects of MNP exposure on the lungs remain unclear and, according to the research team, need to be investigated urgently.

     

    Source:

    Medical University of Vienna

    Journal reference:

    Ernhofer, B., et al. (2025). Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells. Journal of Hazardous Materials. doi.org/10.1016/j.jhazmat.2025.139129.

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  • Microplastics found to trigger cancer-linked changes in lung cells

    Microplastics found to trigger cancer-linked changes in lung cells

    Although the respiratory system is one of the main entry points for microplastics and nanoplastics (MNPs) from the air into the body, little is known about the effects of these tiny particles on the lungs. Researchers at MedUni Vienna have now demonstrated for the first time that MNPs can trigger malignant changes in lung cells that are associated with the development of cancer. The findings were published in the Journal of Hazardous Materials and once again underline the urgent need for action to reduce plastic waste.

    As part of the study, the research team led by Karin Schelch, Balazs Döme and Büsra Ernhofer (all from the Department of Thoracic Surgery and the Comprehensive Cancer Centre at MedUni Vienna) investigated how polystyrene micro- and nanoplastics (PS-MNPs) interact with different types of lung cells. Polystyrene is a plastic widely used in everyday objects, including food packaging and disposable items such as yoghurt pots and coffee-to-go cups. The surprising result of the research: healthy (non-malignant) lung cells absorb particularly small particles (0.00025 millimetres) of PS-MNPs significantly more than malignant cancer cells – and react with biological changes that once again highlight the health risks posed by MNPs.

    Specifically, after contact with the particles, the healthy cells showed increased cell migration, DNA damage, oxidative stress and the activation of signalling pathways that promote cell growth and survival – all processes that are considered early indicators of cancer development. “Particularly striking was the reduced ability of healthy cells to repair DNA damage and the simultaneous activation of certain signalling pathways that normally promote cell growth,” said study leader Karin Schelch, providing details.

    Long-term effects still unclear

    While lung cancer cells remained relatively unaffected under the same conditions, even short-term exposure to MNPs could be enough to influence healthy lung cells in a direction associated with malignant changes. According to the latest research findings, the cells’ defence mechanisms were also triggered under the influence of polystyrene particles. “We observed the activation of antioxidant defence systems – an indication that the cells are actively defending themselves against the stress caused by plastic particles,” explains first author Büsra Ernhofer.

    The lungs are considered one of the main routes of exposure to airborne microplastics. However, little was known about how these particles interact with lung tissue cells.

    The data now available provide initial indications that healthy lung cells in particular react in a way that gives cause for concern.”


    Balazs Döme, co-study leader

    This opens up new questions about the possible link between plastic pollution, chronic lung disease and cancer development – and underscores both the need for interdisciplinary research at the interface between environmental medicine and cancer biology and the need for action to reduce plastic waste. In addition, the long-term effects of MNP exposure on the lungs remain unclear and, according to the research team, need to be investigated urgently.

     

    Source:

    Medical University of Vienna

    Journal reference:

    Ernhofer, B., et al. (2025). Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells. Journal of Hazardous Materials. doi.org/10.1016/j.jhazmat.2025.139129.

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  • SCOTUS on Education Department; Trump on Russia : NPR

    SCOTUS on Education Department; Trump on Russia : NPR

    Good morning. You’re reading the Up First newsletter. Subscribe here to get it delivered to your inbox, and listen to the Up First podcast for all the news you need to start your day.

    Today’s top stories

    The U.S. Supreme Court ruled yesterday that it will allow the Trump administration to resume dismantling the U.S. Department of Education. The Court overruled a lower court that temporarily paused massive cuts at the department. Congress created the department by law and President Trump promised to shut it down without any change in that law, which is why opponents sued.

    The Washington, D.C., headquarters of the U.S. Department of Education shown in March.

    Win McNamee/Getty Images North America


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    Win McNamee/Getty Images North America

    • 🎧 The court’s decision now means that roughly 1,400 Education Department workers will lose their jobs, NPR’s Cory Turner tells Up First. The work that those employees did, including helping local schools support kids with disabilities and children living in poverty, may also cease. The ruling isn’t the final word as the case continues to work its way through lower courts. The plaintiffs’ concern is that by the time they get a final ruling in court, it might not matter, as the harm to the department could be irreversible, Turner stated.

    Some Trump supporters over the weekend were surprised when he urged them to move on from the Epstein files. The Justice Department and the FBI released a two-page memo last week stating they found no evidence to support conspiracy theories about the life and death of disgraced financier and convicted sex trafficker Jeffrey Epstein. They stated he really did kill himself in jail in 2019 and left no client list. This comes after Attorney General Pam Bondi previously said on Fox News that she had the list on her desk.

    • 🎧 Heading into the last election, a central concept of Trump’s MAGA ideology was the belief that there was a deep state cabal of shadowy figures protecting pedophiles and unsavory people running the government and obstructing Trump’s agenda, says NPR’s Stephen Fowler. Now, Trump has a baseless theory about the files, suggesting Democrats created them to target him. Fowler says it is uncertain if Trump’s shift on the topic has hurt his favorability with his supporters, but it does reiterate the stranglehold the president has on the shape and direction of the GOP.

    Trump yesterday threatened to implement heavy tariffs on countries that trade with Moscow if the Kremlin doesn’t reach a ceasefire deal with Ukraine by September. The president also promised Ukraine billions of dollars worth of U.S.-made military equipment, which NATO countries in Europe will pay for.

    • 🎧 NPR’s Charles Maynes says the president’s change of tone on Russia was quite a shift. A big driver in this shift is Trump’s frustration with and even a sense of betrayal by Russian President Vladimir Putin. The president said he thought he had a peace deal with Putin four separate times, only to see Russian attacks in Ukraine continue. Some in Moscow see the 50-day grace period provided for the ceasefire as a sign that Trump isn’t ready to give up on Russia.

    Living better

    Frank Frost found camaraderie in a cycling group in the U.K. that his doctor recommended he try. They call themselves the “Chain Gang" and members look after each other, he said. “We're all of a certain age,” says Frost. “ We don't leave anybody."

    Frank Frost found camaraderie in a cycling group in the U.K. that his doctor recommended he try. They call themselves the “Chain Gang” and members look after each other, he said. “We’re all of a certain age,” says Frost. ” We don’t leave anybody.”

    Frank Frost


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    Frank Frost

    Living Better is a special series about what it takes to stay healthy in America.

    Doctors are writing “social prescriptions” to get people engaged with nature, art, exercise and volunteering in the same way they would prescribe pills or therapy. Research has shown it can help with mental health, chronic disease and dementia. The method worked for Frank Frost. He gained weight and was diagnosed with Type 2 diabetes in his 50s. A doctor found out he used to love riding a bike as a kid and gave him a prescription for a 10-week cycling course for adults getting back into cycling. The prescription led to Frost developing friends, losing 100 pounds and getting his diabetes under control. Julia Hotz, the author of The Connection Cure: The Prescriptive Power of Movement, Nature, Art, Service, and Belonging, shares details on the health approach:

    • 🚲 Health providers in around 30 countries are practicing social prescribing to address symptoms of Type 2 diabetes, chronic pain, dementia, attention deficit hyperactivity disorder, anxiety and depression, and more. A growing number of U.S. providers are also embracing the approach.
    • 🚲 Social prescribing can save money due to a reduction in emergency room visits and repeat visits to primary care physicians. Health care systems have acknowledged that it can be cheaper to cover weeks of Zumba classes than medication over the course of a lifetime.
    • 🚲 People interested in social prescribing can visit the map on Social Prescribing USA’s website to find a list of organizations and health systems involved in this practice.

    Picture show

    Evelyn del Rosario Morán Cojoc, an artist from Guatemala, creates a mural that depicts traditional foods from her Mayan culture — like that floating ear of corn and three yellow beans. She teaches art to kids across the country, encouraging them to depict their indigenous traditions.

    Evelyn del Rosario Morán Cojoc, an artist from Guatemala, creates a mural that depicts traditional foods from her Mayan culture — like that floating ear of corn and three yellow beans. She teaches art to kids across the country, encouraging them to depict their indigenous traditions.

    Ben de la Cruz/NPR


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    Ben de la Cruz/NPR

    The theme of this year’s Smithsonian Folklife Festival in Washington, D.C., was youth and the future of culture. The event showcased a diverse range of talent. A 26-year-old Bolivian rapper infused his unique style into Spanish hip-hop by incorporating words from his father’s indigenous language. Two refugee weavers made a traditional bag as they work to revitalize their ancient art form. A Guatemalan artist created a mural that highlights her Mayan culture. A Mexican American dad and his two daughters demonstrated techniques for shaping a guitar passed down from their great-grandfather. The Goats and Soda team sat down with the four ensembles to talk about their craft, the youth they mentor and the cultural traditions they’re keeping alive. Read what they had to say and see photos of their craft.

    3 things to know before you go

    Andrew Cuomo speaks during an election party following the primaries at the Carpenters Union in New York City on June 24, 2025.

    Andrew Cuomo speaks during an election party following the primaries at the Carpenters Union in New York City on June 24, 2025.

    John Lamparski/AFP via Getty Images


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    John Lamparski/AFP via Getty Images

    1. Former New York Gov. Andrew Cuomo announced yesterday that he is relaunching his campaign for New York City mayor, this time as an independent candidate. (via Gothamist)
    2. South African President Cyril Ramaphosa has suspended his police minister after serious allegations linking him to organized crime.
    3. Los Angeles is now three years away from the Olympic Games, and to commemorate the occasion, organizers yesterday released a preview of the competition schedule. (via LAist)

    This newsletter was edited by Suzanne Nuyen.

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  • Standard Chartered launches bitcoin, ether spot trading for institutional clients – Reuters

    1. Standard Chartered launches bitcoin, ether spot trading for institutional clients  Reuters
    2. Standard Chartered Steps into the Crypto Arena  OneSafe
    3. Standard Chartered Becomes First Global Bank to Launch Bitcoin and Ethereum Spot Trading  Cryptodnes.bg
    4. Standard Chartered Enters Crypto Trading — First Big Bank To Offer Deliverable BTC, ETH To Institutions  Benzinga
    5. Standard Chartered Says It’s the First Global Bank to Offer Spot Bitcoin, Ether Trading  Yahoo Finance

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  • Badminton – BWF Japan Open 2025: Women’s no.1 An through to second round, Kunlavut and Christie eliminated in men’s draw

    Badminton – BWF Japan Open 2025: Women’s no.1 An through to second round, Kunlavut and Christie eliminated in men’s draw

    Women’s badminton world number one An Seyoung continued her fine form as the BWF World Tour season resumed on Tuesday (15 July) with the BWF Japan Open 2025 in Tokyo.

    The Republic of Korea’s An, who has won five of her six World Tour tournaments this year, needed just 38 minutes to see off Thai opponent Ratchanok Intanon.

    A spell of seven consecutive points in each game took the wind out of Ratchanok’s sails as An breezed to a quick 21-14, 21-11 victory.

    She meets compatriot Kim Ga-eun in the last 16 at the Tokyo Metropolitan Gymnasium, with the meeting set for Thursday.

    The Japan Open is available to stream on Olympic Channel via Olympics.com and the Olympics app from the quarter-finals onwards (geographical restrictions apply).

    However, there was differing luck for the men’s top seed and world number one, Kunlavut Vitidsarn of Thailand.

    Facing Weng Hongyang of the People’s Republic of China, Olympic silver medallist Kunlavut found himself trailing by five at 6-11 in the first game before clawing the deficit back to a single point at 11-12.

    But from there, Weng rallied off seven points in a row before closing out to take it 21-13.

    Weng also had a six-point lead in the second at 13-7, and although Kunlavut once more managed to narrow the gap to a single point, Weng saw out the second game to register a 21-13, 21-19 victory.

    Kunlavut wasn’t the only men’s seed to fall on the opening day as fourth seed Jonatan Christie of Indonesia also crashed out.

    Christie, facing home shuttler Nishimoto Kenta, was despatched 13-21, 12-21 in just 45 minutes.

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  • Badminton – BWF Japan Open 2025: Women’s no.1 An through to second round, Kunlavut and Christie eliminated in men’s draw

    Badminton – BWF Japan Open 2025: Women’s no.1 An through to second round, Kunlavut and Christie eliminated in men’s draw

    Women’s badminton world number one An Seyoung continued her fine form as the BWF World Tour season resumed on Tuesday (15 July) with the BWF Japan Open 2025 in Tokyo.

    The Republic of Korea’s An, who has won five of her six World Tour tournaments this year, needed just 38 minutes to see off Thai opponent Ratchanok Intanon.

    A spell of seven consecutive points in each game took the wind out of Ratchanok’s sails as An breezed to a quick 21-14, 21-11 victory.

    She meets compatriot Kim Ga-eun in the last 16 at the Tokyo Metropolitan Gymnasium, with the meeting set for Thursday.

    The Japan Open is available to stream on Olympic Channel via Olympics.com and the Olympics app from the quarter-finals onwards (geographical restrictions apply).

    However, there was differing luck for the men’s top seed and world number one, Kunlavut Vitidsarn of Thailand.

    Facing Weng Hongyang of the People’s Republic of China, Olympic silver medallist Kunlavut found himself trailing by five at 6-11 in the first game before clawing the deficit back to a single point at 11-12.

    But from there, Weng rallied off seven points in a row before closing out to take it 21-13.

    Weng also had a six-point lead in the second at 13-7, and although Kunlavut once more managed to narrow the gap to a single point, Weng saw out the second game to register a 21-13, 21-19 victory.

    Kunlavut wasn’t the only men’s seed to fall on the opening day as fourth seed Jonatan Christie of Indonesia also crashed out.

    Christie, facing home shuttler Nishimoto Kenta, was despatched 13-21, 12-21 in just 45 minutes.

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  • Banking climate alliance battles to retain big European lenders – Financial Times

    Banking climate alliance battles to retain big European lenders – Financial Times

    1. Banking climate alliance battles to retain big European lenders  Financial Times
    2. HSBC Exits Net Zero Banking Alliance  ESG Today
    3. HSBC joins US banks in quitting climate coalition  Reuters
    4. HSBC becomes first UK bank to quit industry’s net zero alliance  The Guardian
    5. Is HSBC Abandoning Its Net Zero Targets After NZBA Dropout?  Sustainability Magazine

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