Infinix launched two new Hot 60 Pro series phones yesterday, and we now have another entry – the Hot 60 5G. This one features MediaTek’s Dimensity 7020 chipset with full 5G support, unlike the rest of the Hot 60 series, which are limited to 4G connectivity.
Infinix Hot 60 5G
Hot 60 5G is built around a flat 6.7-inch IPS LCD (FHD+ 120Hz) and Panda Glass protection. The panel is rated at up to 700 nits peak brightness and features an 8 MP front-facing camera.
There’s a 50MP main shooter with an f/1.6 aperture around the back, which is paired with two unspecified auxiliary sensors.
The phone is IP64-rated against water and dust and features a dedicated AI button which quickly launches the Folax smart assistant. You also get a 3.5mm audio jack, an FM Radio receiver and expandable storage thanks to its microSD card slot.
Hot 60 5G packs a 5,200mAh battery with 18W charging and it supports bypass charging and reverse wired charging over USB. The software side is covered by XOS 15, based on Android 15, with Infinix pledging two years of security patches.
Infinix Hot 60 5G comes in Shadow Blue, Tundra Green, Sleek Black, and Caramel Glow colors. The 6/128GB trim is priced at INR 10,499 ($122). First sales in India start on July 15 from the official Infinix online store.
The recently discovered interstellar visitor 3I/ATLAS may be one of the oldest comets ever seen by humanity.
The object was already exciting to astronomers as only the third space object seen entering the solar system from beyond its limits, the other two being 1I/’Oumuamua seen in 2017 and 2I/Borisov detected in 2019.
However, new research has shown this potentially “water ice-rich” visitor could be even more extraordinary than initially believed. 3I/ATLAS could be around 3 billion years older than our 4.5 billion-year-old solar system and thus any comet ever before observed.
University of Oxford astronomer Matthew Hopkins is part of a team of scientists that think 3I/ATLAS, discovered on July 1, 2025 by the ATLAS survey telescope, is around 7 billion years old.
“All non-interstellar comets, such as Halley’s comet, formed at the same time as our solar system, so they are up to 4.5 billion years old,” Hopkins said in a statement. “But interstellar visitors have the potential to be far older, and of those known about so far, our statistical method suggests that 3I/ATLAS is very likely to be the oldest comet we have ever seen.”
The secret to 3I/ATLAS’ old age
The key to the advanced age of 3I/ATLAS is the fact that it comes from a completely different region of the Milky Way than previous interstellar visitors.
Based upon the steep trajectory that 3I/ATLAS appears to be taking through our galaxy, Hopkins and colleagues theorize that it originated in the Milky Way’s “thick disk” of stars.
Breaking space news, the latest updates on rocket launches, skywatching events and more!
The thick disk is a band of our galaxy’s most ancient stars that sandwiches the thin disk, which formed more recently and contains our relatively young star, the sun, and the solar system.
“This is an object from a part of the galaxy we’ve never seen up close before,” University of Oxford astrophysicist Chris Lintott said. “We think there’s a two-thirds chance this comet is older than the solar system, and that it’s been drifting through interstellar space ever since.”
The potentially 7 billion year old interstellar comet 3I/ATLAS traveling through a background of stars. (Image credit: ESA)
If 3I/ATLAS originates from the Milky Way’s thick stellar disk, and thus formed around an ancient star, this also has implications for its chemical composition. Hopkins and crew suggest the interstellar interloper may be rich in water ice.
As 3I/ATLAS gets closer to the sun, it will get warmer. Frozen ices will turn to gas, a process called sublimation, and erupt from the surface of the comet.
This outgassing will give 3I/ATLAS a cometary aura, or “coma,” and a bright tail, the familiar and distinctive characteristics of comets.
Observations have already indicated that 3I/ATLAS is bursting to life with cometary activity. These observations also seem to indicate that 3I/ATLAS is bigger than previous interstellar invaders 1I/’Oumuamua and 2I/Borisov.
“We’re in an exciting time, 3I/ATLAS is already showing signs of activity. The gases that may be seen in the future as 3I/ATLAS is heated by the sun will test our model,” team member Michele Bannister, of the University of Canterbury in New Zealand, said. “Some of the biggest telescopes in the world are already observing this new interstellar object – one of them may be able to find out!”
Stacked images of interstellar comet 3I/ATLAS taken by ESO’s Very Large Telescope (VLT) on July 8, 2025. (Image credit: ESO/O. Hainaut)
One of the telescopes that will be trying to get a look at 3I/ATLAS will be the Vera C. Rubin Observatory.
In fact, this interstellar visitor was first spotted as scientists were preparing to make observations with Rubin, which they predict will uncover between 5 and 50 interstellar objects passing through the solar system as it conducts the 10-year-long Legacy Survey of Space and Time (LSST).
“The discovery of 3I/ATLAS suggests that prospects for Rubin may now be more optimistic; we may find about 50 objects, of which some would be similar in size to 3I/ATLAS.
“This week’s news, especially just after the Rubin First Look images, makes the upcoming start of observations all the more exciting.”
The model the team used to investigate the origins of 3I/ATLAS was developed by Hopkins as part of his doctoral thesis, one he defended just one week before the interstellar object was discovered.
Rather than heading on vacation, Hopkins found himself applying the model, dubbed the Ōtautahi–Oxford Model, in real-time for the first time. The test subject: 3I/ATLAS.
“Rather than the quiet Wednesday I had planned, I woke up to messages like ‘3I!’ It’s a fantastic opportunity to test our model on something brand new and possibly ancient,” Hopkins concluded.
Hopkins discussed the 3I/ATLAS findings on Friday (June 11) at the Royal Astronomical Society National Astronomy Meeting (NAM) 2025 at Durham University in the UK.
A mystery interstellar object spotted last week by astronomers could be the oldest comet ever seen, according to scientists.
Named 3I/Atlas, it may be three billion years older than our own solar system, suggests the team from Oxford university.
It is only the third time we have detected an object that has come from beyond our solar system.
The preliminary findings were presented on Friday at the national meeting of the UK’s Royal Astronomical Society in Durham.
“We’re all very excited by 3I/Atlas,” University of Oxford astronomer Matthew Hopkins told BBC News. He had just finished his PhD studies when the object was discovered.
He says it could be more than seven billion years old, and it may be the most remarkable interstellar visitor yet.
3I/Atlas was first spotted on 1 July 2025 by the ATLAS survey telescope in Chile, when it was about 670 million km from the Sun.
Since then astronomers around the world have been racing to identify its path and discover more details about it.
Mr Hopkins believes it originated in the Milky Way’s ‘thick disk’. This is a group of ancient stars that orbit above and below the area where the Sun and most stars are located.
The team believe that because 3I/ATLAS probably formed around an old star, it is made up of a lot of water ice.
That means that as it approaches the Sun later this year, the energy from the Sun will heat the object’s surface, leading to blazes of vapour and dust.
That could create a glowing tail.
The researchers made their findings using a model developed by Mr Hopkins.
“This is an object from a part of the galaxy we’ve never seen up close before,” said Professor Chris Lintott, co-author of the study.
“We think there’s a two-thirds chance this comet is older than the solar system, and that it’s been drifting through interstellar space ever since.”
Later this year, 3I/ATLAS should be visible from Earth using amateur telescopes.
Before 3I/Atlas soared into view, just two others had been seen. One was called 1I/’Oumuamua, found in 2017 and another called 2I/Borisov, discovered in 2019.
Astronomers globally are currently gearing up to start using a new, very powerful telescope in Chile, called the Vera C Rubin.
When it starts fully surveying the southern night sky later this year, scientists expect that it could discover between 5 and 50 new interstellar objects.
Thank you. Listen to this article using the player above. ✖
In a world-first pilot study, researchers from the University of South Australia (UniSA) have used video footage of insects to extract their heart rates without touching or disturbing them.
The innovation, published in the Archives of Insect Biochemistry and Physiology, could transform how scientists monitor the health and stress levels of arthropods, that account for more than 80% of animal species.
Taking footage from smartphones, social media videos and digital cameras, the researchers used sophisticated signal processing methods to monitor the heart activity of ants, bees, caterpillars, spiders, grasshoppers and stick insects.
Unlike mammals, arthropods have an open circulatory system in which blood fills the body cavity, bathing the internal organs and tissues. Their heart is located on the top (dorsal) side of their body in the abdomen.
Led by UniSA PhD candidate Danyi Wang and her supervisor Professor Javaan Chahl, the study demonstrates that subtle body movements captured on standard digital or smartphone cameras can be analyzed to reveal accurate and detailed cardiac activity in a range of insect species.
Unlike traditional methods that require physical contact or immobilization, this technique allows insects to remain free, without disrupting their natural behavior.
“Insects are vital to our ecosystems, and understanding their physiological responses to environmental change is essential,” Wang says.
“Existing methods to measure insect’ vital signs are invasive, however. Our method preserves their natural behavior while providing accurate insights into their heart activity.”
The extracted heart rates closely matched the physiological ranges recorded via traditional techniques, validating the system’s accuracy.
Senior author Prof Javaan Chahl says the system successfully captured heart rates across multiple insect species, detecting physiological differences influenced by factors such as wing morphology and temperature.
“What’s exciting is that this was all achieved without attaching sensors or disturbing the insects in any way.”
One of the most impressive validations came from caterpillar recordings, where the team compared their video-derived cardiac signals to data from infrared contact sensors in previous studies. The shapes and frequencies were almost identical.
The study also revealed interesting inter-species variations. For example, spider heart rates varied significantly, reflecting differences between species rather than activity levels, since all subjects were at rest during filming.
Advanced image processing techniques, including motion tracking algorithms and magnification, were applied to detect tiny movements associated with heartbeats. These signals were analyzed using spectral filtering and transformed into frequency data to isolate the heart rate.
According to Prof Chahl, the study marks an important step forward in insect research.
“Non-invasive cardiac monitoring offers tremendous potential; not just for studying insect health, but also for understanding environmental stressors, pesticide effects, or even the wellbeing of social insects like ants and bees, where heart signals can provide insights into colony health and behavior.”
His team has previously used a similar technique with digital cameras to remotely extract cardiac signals in humans and wildlife.
The researchers hope to test the system in the field and refine it by using machine learning to improve the accuracy across different body types and light conditions.
“With more refinement, this could become a cost effective and valuable tool in the ecological research toolkit,” says Wang. “It gives us the ability to listen to the hearts of the smallest creatures without harming them.”
Reference: Wang D, Chahl J. Extracting cardiac activity for arthropods using digital cameras: Insights from a pilot study. Insect Biochem Physio. 2025. Doi: 10.1002/arch.70076
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.
“There should be a buffet at every comedy gig,” says Manchester-based Molly McGuinness – and luckily for us, she’s making that happen for her Edinburgh debut. Her laugh-packed sets, served with snacks and a warm conversational style, are inspired by the standup of Caroline Aherne. “I like it to feel as if I’m talking to a friend,” she says. Slob began as a turning-30 existential crisis about reaching your potential, but when a rare disease left McGuinness in a coma, everything shifted. She will share the “bizarre and surreal” experience of coma-induced delirium, tender reflections on “the sweetness of the nurses” that cared for her, and a blossoming love story. “A lot of people feel like a slob, but we’re doing the best we can,” she says. Monkey Barrel, 28 July–24 August
Simple Town
US group Simple Town make consistently brilliant short films, where everyday conundrums (what’s the meaning of “adroit”? What happens if you’re late for a funeral?) escalate to extremes, or descend into meta-narratives about the absurdity of online content. The foursome, who started performing regularly in New York around 2017, are bringing an hour of “pure sketch comedy” for their fringe debut. Their previous visits to the UK sold out fast. “Our work is somewhere between alternative and crowd-pleasing. Sometimes it’s brainy, ‘comedian’s comedian’ humour, but we also work very hard for the shows to be silly, broad, fast-paced, and fun,” they say. “So hopefully, both kinds of audiences will find something in the show to hate.” Pleasance Courtyard, 11–24 August
Jessica Barton in Dirty Work. Photograph: Paul Westbrook
Dirty Work
Australian performer Jessica Barton started out in musical theatre and got her first taste of comedy at French clown school Gaulier. She began to “play using song and movement, physical comedy and clowning”, moved to London and immersed herself in its alternative comedy scene. Dirty Work combines her vocal talents with playful audience interaction. In character as Floppins – a Mary Poppins-esque figure intent on cleaning up the stage – she cleverly explores gendered domestic roles. “Expect to have a lot of fun,” she says. “Expect to be challenged and to rise to the occasion. Especially the men in the audience.” Dirty Work was awarded best newcomer at Melbourne international comedy festival and as she gets deeper into the character: “I’ve enjoyed finding new things within the world I’ve created.” Underbelly Cowgate, 31 July–24 August
Ayoade Bamgboye: Swings and Roundabouts
Her assured presence and sideways perspective make Ayoade Bamgboye stand out on any lineup, despite having only three years of live comedy under her belt. She had been working as a writer when someone suggested she try it and Bamgboye is always experimenting, incorporating clowning, multimedia forays and different personae into her performances. She “grew up between London and Lagos” and gives a unique twist on observational comedy: “I’m looking at everything as if I’m on safari. I’m a curious silly billy.” Bamgboye says her comedy has sometimes been “confrontational and caustic” with spicy punchlines on racism and colonialism, but with her debut she’s ready to be more vulnerable, too: “Audiences should expect something bittersweet.” Pleasance Courtyard, 30 July–24 August
Sharon Wanjohi: In the House. Photograph: Rebecca Needmenear
Sharon Wanjohi: In the House
She first tried standup at university in Southampton (“We had a comedy society where all the nerds went”) and quickly racked up finalist spots at the Funny Women and BBC new comedy awards. Now, Sharon Wanjohi is making her fringe debut with a show about self-help culture and the zeitgeisty coping mechanisms that are “shoved down our throats” every day. “I’m presenting myself as this 90s talkshow host, in the mould of Trisha and Oprah”, Wanjohi says. “I’m satirising self-help, but also breaking out of character to do standup.” You’ll get a gen Z spin on societal issues like the housing crisis, but something “goofy, silly, less grounded in reality,” Wanjohi promises. Pleasance Courtyard, 30 July–24 August
Roger O’Sullivan: Fekken
This 90s-tinted debut from Irish comedian Roger O’Sullivan explores his relationship with his farmer father via Tekken and the rest of young Roger’s favourite PlayStation games. He started out on Cork’s small comedy scene eight years ago, where “there weren’t really any stakes, so any gig you’d do something new and try the weirdest thing. That’s the mentality I’ve had from early on.” He’s had success online with lo-fi animations, which he works into the show to great effect. “I wanted to end with a callback to retro video games and thought it would be really funny if I learned 3D animation just for that.” Expect warm standup that melds “a little bit of heart with absurdism”. PBH’s Free Fringe @ Carbon and Hoots @ The Apex, 2–23 August
In 2022, NASA rammed a spacecraft into an asteroid to see if it could alter its orbital period around its parent asteroid. The mission, dubbed the Double Asteroid Redirection Test (DART), aimed to determine whether humanity could theoretically save itself from a catastrophic asteroid impact.
DART collided with Dimorphos, a small moonlet orbiting a larger asteroid called Didymos, on September 26, 2022. The results of the impact blew NASA’s expectations out of the water, shortening Dimorphos’s orbital period by 32 minutes. Such a change would be more than enough to deflect a dangerous asteroid away from Earth, indicating that this strategy—the kinetic impactor technique—could save us if necessary. New research, however, complicates this success story. An investigation into the debris DART left behind suggests this technique, when applied to planetary defense, isn’t as straightforward as scientists initially thought.
“We succeeded in deflecting an asteroid, moving it from its orbit,” said study lead author Tony Farnham, a research astronomer at the University of Maryland, in a statement. “Our research shows that while the direct impact of the DART spacecraft caused this change, the boulders ejected gave an additional kick that was almost as big. That additional factor changes the physics we need to consider when planning these types of missions.” Farnham and his colleagues published their findings in The Planetary Science Journal on July 4.
Dimorphos is a “rubble pile” asteroid, a loose conglomeration of material such as rocks, pebbles, and boulders held together by gravity. This study only applies to this type of asteroid. Had DART collided with a more coherent, solid body, the impact wouldn’t have produced these bizarre effects. Still, there are plenty of other rubble pile asteroids in the galaxy, so understanding how they respond to the kinetic impactor technique is important.
The researchers analyzed images taken by LICIACube, an Italian Space Agency satellite that was mounted on the DART spacecraft. About two weeks before the impact, LICIACube separated and began following about three minutes behind the spacecraft, allowing the satellite to beam images of the collision and its effects back to Earth. In addition to observing the crater DART punched into the surface of Dimorphos, LICIACube captured the ejecta plume, or the cloud of debris ejected from the asteroid when DART hit it.
These images allowed Farnham and his colleagues to track 104 boulders ranging from 1.3 to 23.6 feet (0.4 to 7.2 meters) wide. The rocks shot away from the asteroid at speeds up to 116 miles per hour (187 kilometers per hour). Strangely, the distribution of this ejected debris was not random, defying the researchers’ expectations.
“We saw that the boulders weren’t scattered randomly in space,” Farnham said. “Instead, they were clustered in two pretty distinct groups, with an absence of material elsewhere, which means that something unknown is at work here.”
The larger of the two clusters, which contained 70% of the debris, shot southward away from the asteroid at high speeds and shallow angles. The researchers believe these objects came from a specific source on Dimorphos—perhaps two large boulders called Atabaque and Bodhran that shattered when DART’s solar panels slammed into them moments before the main body of the spacecraft hit.
When the team compared this outcome to that of NASA’s Deep Impact (EPOXI) mission, which punched a probe into a comet to study its interior structure, the distribution of the debris made more sense. Whereas Deep Impact hit a surface made up of very small, uniform particles, DART hit a rocky surface packed with large boulders. This “resulted in chaotic and filamentary structures in its ejecta patterns,” coauthor Jessica Sunshine, a professor of astronomy and geology at the University of Maryland who served as principal investigator for Deep Impact, explained in the statement.
“Comparing these two missions side-by-side gives us this insight into how different types of celestial bodies respond to impacts, which is crucial to ensuring that a planetary defense mission is successful,” she said.
The 104 ejected boulders carried a total kinetic energy equal to 1.4% of the energy of the DART spacecraft, and 96% of that energy was directed to the south, representing “significant momentum contributions that were not accounted for in the orbital period measurements,” the researchers state in their report. The force of debris exploding away from Dimorphos upon DART’s impact could have tilted the asteroid’s orbital plane by up to one degree, potentially causing it to tumble erratically in space.
“Thus, a full accounting of the momentum in all directions and understanding the role played by surface boulders will provide better knowledge of how the specifics of the impact could alter—either reducing or enhancing—the effects of a kinetic impactor,” the researchers write.
Astronomers have catalogued roughly 2,500 potentially hazardous asteroids in our corner of the galaxy. These are space rocks that can come alarmingly close to Earth and are large enough to cause significant damage upon impact. While there is currently no known risk of one of these asteroids hitting our planet within the next century, developing strategies to prevent such a catastrophe could someday prove lifesaving. The success of the DART mission suggests that NASA is on the right track, but this new study shows we still have much to learn about the effects of the kinetic impactor technique.
Discover more Featured Stories like this in The Strad Playing Hub
It’s 6:30am in Moshi, Kilimanjaro region. The sun is starting to rise daily at the same time as it is near the equator. The singing of roosters and other birds blends with the sounds of beeping boda bodas from the nearby road. The snow-covered top of Mount Kilimanjaro is coming out from the clouds. The security guard keeps talking loudly on the phone near the home windows, keeping some volunteers awake. It is another day of teaching at Daraja Music Initiative, the programme that bridges music education and nature conservation.
The programme was initiated by Michele Von Haugg under the name ’Clarinets for Conservation.’ She got the inspiration to come to Tanzania after seeing a documentary Mpingo – the tree that makes music. Now the programme is run by executive director clarinetist Ian Tyson from New York. First, it was a clarinet-only programme, but later on, the violin was added to it. Some of the students can play both the violin and the clarinet.
Mpingo, the African Blackwood tree, is special – it is the national tree of Tanzania. Not only are beautiful carvings made of this durable and expensive tree, but also musical instruments such as clarinets, oboes, and parts of the string instruments such as fingerboards, chin rests, pegs, and bow frogs.
The tree is over-harvested and not enough replenished, but during the 15 years of the programme, many trees have been planted at local Moshi schools, and students are being taught about the environmental and economic value of the tree and how to take good care of it.
The programme is truly building community and empowering students and local families in many ways. A former student of the programme, Michael Boaz, opened his own NGO non-profit organisation in Dar es Salaam called ’Music for Hope’ three years ago. Many older students aspire to travel abroad for the first time and have dreams to come to study in foreign universities to obtain music education degrees.
Every Thursday, students, together with volunteer teachers, perform at the local coffee shop ’Union Coffee’ owned by a parent of a student. These performances are very special as all students can showcase their skills, like a new scale or just the new three notes that they have learnt on the D-string.
A touching moment for me was playing together my arrangement of Mbuga Za Wanyama Tanzania. One of the seven-year-old violin students was conducting our little ensemble, and the whole audience joined in singing and cheering at the end. We were using my battery-operated lantern because the lights were so dim that we could barely see the music, but luckily, I also brought many spare batteries for the stand lights.
Weekly Friday performances of the programme take place in the Courage Cafe. This cafe is special because it supports women who have been victims of sexual abuse and trafficking. Women who are recovering from these severely challenging circumstances make clothes, bracelets, earrings, and other souvenirs that are sold at the store of this cafe.
The programme has run for 15 years, and many of the small students have grown and now are in need of the full-size violins. There is a lack of full-size violins, and many students need to play on violins that are a size or two too small. Even though there are many violins donated to the programme, the challenge is how to transport them from the US to Tanzania. I was able to bring three new violins to the programme, generously donated by my student Shwetha Manimaran and her mom, Nivetha.
In Tanzania, there are no shops where you can buy violins or strings, and no luthiers. One day, I was checking Makumira College student Fraterin Shayo’s violin to see if it had no open seams and was changing his three-year-old strings to a new set, and I noticed that his bridge was very crooked. I had a brand new spare bridge with me from America, and we decided to put it on. In the process of changing the bridge, the sound post fell down. I had never put in the sound post before that. After watching a YouTube video tutorial and one and a half hours of trying and failing, I managed to put the sound post back in with the tools that the programme luckily had. A few days later, the sound post fell down again. With another hour and a half and a more careful try, I was able to put it back in, and the violin sounded so beautiful with an open and ringing tone. I was extremely relieved that we managed to do it without access to any of the luthiers, and I only ended up with one bloody finger because of pinching it with the sharp edge of the tool.
Tanzania is a country to fall in love with and return to, and music is a universal language that can bridge and build international communities. Planting seeds of mpingo trees and planting the seed of education, kindness, and resilience in each and every student, and then watching it grow and flourish.
There are important lessons to learn from the community of Daraja Music Initiative – in a world full of hatred, conflict, and division, there is something beautiful and more important, which is the future of our planet and children. It’s in our daily steps that we can either build or destroy. With every note we play, with each lesson we teach, and with each tree we plant, we can create a compound and sustainable effort that will make an impact on our future generations.
All photos courtesy Aija Reke.
In The Best of Technique you’ll discover the top playing tips of the world’s leading string players and teachers. It’s packed full of exercises for students, plus examples from the standard repertoire to show you how to integrate the technique into your playing.
In the second volume of The Strad’s Masterclass series, soloists including James Ehnes, Jennifer Koh, Philippe Graffin, Daniel Hope and Arabella Steinbacher give their thoughts on some of the greatest works in the string repertoire. Each has annotated the sheet music with their own bowings, fingerings and comments.
The Canada Council of the Arts’ Musical Instrument Bank is 40 years old in 2025. This year’s calendar celebrates some its treasures, including four instruments by Antonio Stradivari and priceless works by Montagnana, Gagliano, Pressenda and David Tecchler.
The strength of England’s bench has been questioned this year. In theory, with 13 players on duty in Australia, it should be under even more pressure.
However, England finished on the front foot in the first Test, pushing for more points rather than clinging on for victory.
It is a young set of replacements – six of the eight are 24 or under – and the experience gained at the business end of a Test series in front of a loud, away support will be priceless.
Borthwick spoke about this tour being a chance to build and reveal Test-match temperament in his youngsters. That focus may be most acute on these finishers.
Twenty-year-old Asher Opoku-Fordjour, who came under pressure in Sale’s Premiership semi-final defeat by Leicester, will relish the chance to prove himself.
Chandler Cummingham-South, who is attempting to add second row to his repertoire, needs to rediscover his rampaging best.
The broken field and tired opposition might suit the all-court skills of Theo Dan, centrally-contracted, but third choice at hooker behind Luke Cowan-Dickie and Jamie George.
Cadan Murley is exorcising the ghosts of a difficult debut in Dublin, while Jack van Poortvliet, who would have travelled to the last World Cup as England’s first choice scrum-half but for a late injury, is pushing hard to move up the pecking order.
Unlike the brain and spinal cord, peripheral nerve cells, whose long extensions reach the skin and internal organs, are capable of regenerating after injury. This is why injuries to the central nervous system are considered irreversible, while damage to peripheral nerves can, in some cases, heal, even if it takes months or years. Despite decades of research, the mechanisms behind peripheral nerve regeneration remain only partially understood. In a new study published in Cell, researchers from Prof. Michael (Mike) Fainzilber’s lab at the Weizmann Institute of Science discovered that a family of hundreds of RNA molecules with no known physiological function is essential to nerve regeneration. Remarkably, the study showed that these molecules can stimulate growth not only in the peripheral nervous system of mice but also in their central nervous system. These findings could pave the way for new treatments for a variety of nerve injuries and neurodegenerative diseases.
For a peripheral nerve to regenerate, it must maintain communication between the neuron’s cell body and its long extension – the axon – which in humans can reach more than a meter in length. In a series of studies over the past two decades, Fainzilber’s lab has revealed key components of this communication: proteins that act like postal couriers, delivering instructions for the production of growth-controlling factors and other proteins, from the cell body to the axon. These molecular couriers also help assess the distance between the cell body and the axon tip, allowing the neuron to modulate its growth accordingly. Yet one central issue remained: What triggers the regenerative growth after injury, and why does this not happen in central nervous system cells?
“While the growth acceleration observed in our study is not yet sufficient to address clinical paralysis, it is definitely significant”
In the new study, Dr. Indrek Koppel of Fainzilber’s lab, in collaboration with Dr. Riki Kawaguchi of the University of California, Los Angeles (UCLA), examined a specific kind of gene expression in the peripheral nerves of mice following injury. The researchers were surprised to find that one day after damage, the neurons increased the expression of an entire family of short genetic sequences called B2-SINEs, whose role was previously unknown. These sequences do not encode any proteins, and because they are known for “jumping” around the genome, meaning that they can appear at the wrong place or time, they have a bad reputation. But the researchers found that after injury, the neurons began expressing many B2-SINE RNA transcripts, in parallel with other processes preparing the cell for regeneration and repair.
However, B2-SINE is an enormous family, comprising some 150,000 sequences scattered throughout the mouse genome. The initial analysis could not determine which of these were responsible for promoting growth. Dr. Eitan Erez Zahavi, also of Fainzilber’s lab, who led the new study alongside Koppel, used bioinformatics tools to identify 453 B2-SINE sequences that are highly expressed after injury, promoting nerve growth. Collaborating with international research teams, the scientists showed that this overexpression after injury is unique to peripheral nerve cells and does not occur in the central nervous system.
The periphery leads, the center follows
The researchers then tested whether B2-SINEs from peripheral nerve cells could also stimulate neuronal growth in the central nervous system. They induced retinal neurons in mice to overexpress RNA molecules of the B2-SINE type and observed faster regeneration after injury. A similar experiment in the mouse motor cortex – the brain region that controls muscle movement via long axons projecting to the spinal cord – showed that neurons expressing high levels of B2-SINE also regenerated faster than control neurons.
“There are still no effective treatments to accelerate nerve cell growth and regeneration,” Fainzilber notes. “While the growth acceleration observed in our study is not yet sufficient to address clinical paralysis, it is definitely significant. Of course, the path from basic research to clinical application is long, and we must make sure that enhancing growth mechanisms does not, for example, increase the risk of cancer.”
One final mystery remained: How do B2-SINE RNA molecules actually promote regeneration? With help from Prof. Alma L. Burlingame’s group at the University of California, San Francisco, the researchers discovered that these RNAs promote a physical link between the molecular “couriers” carrying instructions for producing growth-associated proteins and the ribosomes that read these instructions and carry them out. This means that production of the critical factors takes place closer to the cell body rather than to the tip of the axon. The researchers believe that this signals to the neuron that it is “too small,” triggering a growth response.
“There are over a million sequences called Alu elements in the human genome, the human equivalent of B2-SINEs in mice,” says Fainzilber. “These molecules had been previously shown to bind to ribosomes and mail couriers, but why this happens was unknown. We’re now trying to determine whether Alu or other noncoding RNA elements are involved in nerve regeneration in humans.”
“Recovery from peripheral nerve injuries, or from systemic diseases like diabetes that affect these nerves, can be very slow,” he adds. “That’s why we’re now testing a therapy that might speed up regeneration by mimicking B2-SINE activity. This therapy involves small molecules that connect the couriers to ribosomes while keeping them close to the nerve cell body, promoting faster growth. We are conducting this research in collaboration with Weizmann’s Bina unit for early-stage research with applicative potential.”
Beyond promoting peripheral nerve regeneration, the new study also hints at an even broader prospect: regeneration in the central nervous system. “We are currently working with UCLA on a study showing that the mechanism we discovered plays a role in recovery from stroke in mouse models,” Fainzilber says. “Additionally, we’re collaborating with Tel Aviv University, Hebrew University and Sheba Medical Center to study its possible role in ALS, a progressive neurodegenerative disease. Neurodegenerative conditions affect many millions of people worldwide. While the road ahead is long, I truly hope we’ll one day be able to harness our newly discovered regeneration mechanism to treat them.”
Reference: Zahavi EE, Koppel I, Kawaguchi R, et al. Repeat-element RNAs integrate a neuronal growth circuit. Cell. 2025. doi: 10.1016/j.cell.2025.04.030
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.