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  • OHSU research drives FDA approval for novel use of anemia drug in brain cancer imaging

    OHSU research drives FDA approval for novel use of anemia drug in brain cancer imaging

    Researchers with OHSU’s Neuro-Oncology Blood-Brain Barrier Program supported several clinical trials investigating a novel use of a drug for brain cancer imaging; the data helped achieve its recent FDA-approval. (OHSU/Christine Torres…

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  • Prevalence of Alzheimer’s disease pathology in the community

    Prevalence of Alzheimer’s disease pathology in the community

    Dementia is a growing global challenge, with Alzheimer’s disease (AD) being the most common cause, characterized by ADNCs, encompassing brain deposits of amyloid-β (Aβ) plaque and neurofibrillary tau tangles. The prevalence of dementia and…

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  • Colyer, Booth earn AVCA All-American honors

    Colyer, Booth earn AVCA All-American honors

    MADISON, Wis. – After a pair of stellar individual seasons, seniors Mimi Colyer and Carter Booth of the Wisconsin volleyball team each garnered All-America honors from the American Volleyball Coaches Association, as announced on Wednesday…

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  • Brazil’s Mobile Electron Beam Accelerator

    Brazil’s Mobile Electron Beam Accelerator

    Electron beam treatment of wastewater is highly effective, but still relatively unknown in many industrial sectors. To increase the awareness of this application, Brazil has made the unit mobile, with support from the Republic of Korea. Worldwide, only a handful of transportable e-beam accelerators are in use for industrial applications. The truck-mounted accelerator will be able to visit industrial sites around the country with ease – showcasing how e-beam irradiation can solve wastewater challenges and providing an opportunity for in-person training. The mobile irradiator has already been tested for various applications in chemical, oil, and sanitation sectors, such as São Paulo Sanitation Company and Petrobras. It has also been used for training purposes including with the National Industrial Apprenticeship Service.  

    “Together, we developed the mobile unit, which uses nuclear technology — an e-beam accelerator — to degrade organic compounds in wastewater,” said Wilson Calvo, Director of Research and Development, CNEN. “The main proposal is to reuse this water, for example from clothing production or industrial applications,” he said. 

    The unit, equipped with a 700 keV, 28.5 mA and 20 kW industrial electron accelerator, was established by the Nuclear and Energy Research Institute (IPEN), which is part of CNEN, supported by the IAEA technical cooperation programme, the Brazilian Innovation Agency, the National Research Council and Truckvan. Wastewater flows directly through the unit, where it is irradiated by the e-beam accelerator. This breaks down toxins and makes any additional conventional treatments more efficient. Up to 1000 cubic metres of wastewater can be treated every day.  

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  • PTI decides to contest Islamabad local govt elections despite ‘rigging’ fears – Dawn

    1. PTI decides to contest Islamabad local govt elections despite ‘rigging’ fears  Dawn
    2. Local PTI chapter sets up LG polls committee  Dawn
    3. Federal capital: LG polls: nominations today  Business Recorder
    4. PTI Islamabad forms committee for local…

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  • IMF Executive Board Concludes The 2025 Review of the Short-Term Liquidity Line

    IMF Executive Board Concludes The 2025 Review of the Short-Term Liquidity Line

    Washington, D.C.: The Executive Board of the International Monetary Fund (IMF) has formally completed its review of the Short-Term Liquidity Line (SLL) on December 17th. The Review concluded that the SLL will terminate in April 2027, at the end of the seven-year period following its establishment, in line with the original design of the instrument.

    Introduced in 2020, the SLL was established as a revolving and renewable backstop for countries with very strong economic fundamentals, policies, and track records of policy implementation. It provides liquidity support for members facing potential short-term, moderate balance of payments difficulties, reflected in pressures on the capital account and reserves and resulting from volatility in international capital markets. The SLL aims to help prevent emerging liquidity pressures from escalating into broader macroeconomic or financial instability. Since its inception, uptake has been limited.

    The 2025 review was informed by an IMF staff paper. Staff’s analysis highlighted the SLL’s role within the Global Financial Safety Net (GFSN) since the pandemic and its distinctive features within the IMF’s precautionary toolkit, including revolving access and cost advantages. However, the review also noted that the SLL’s attractiveness may be constrained compared to the FCL, which covers broader balance of payments problems, offers higher access, a longer repayment period, and has a more established signaling effect, while sharing the same qualification criteria.

    An informal meeting with Executive Directors was held on November 10, 2025, to discuss the review and the future of the SLL. The staff paper considered the merit of a short-term extension of the SLL term through October 2028, to allow for a decision on the SLL to be made in the context of the next comprehensive review of the IMF instruments available for precautionary lending. A range of views was expressed by Executive Directors with indications that support for such a short-term extension would be insufficient. Qualifying countries may request approval of SLL arrangements up until it is scheduled to lapse on April 14, 2027. Pursuant to the SLL policy, approved arrangements during this period will remain in effect until the earlier of the expiration or cancellation of the arrangement by the member.

    Looking ahead, a comprehensive review of the IMF’s instruments available for precautionary lending is tentatively planned for 2028. This review will incorporate lessons learned since the 2023 review of the FCL, SLL and PLL, and broad-based feedback from stakeholders. The objective will be to assess the IMF’s toolkit available for precautionary lending holistically, strengthen their effectiveness in supporting members’ balance of payments positions and crisis prevention, and address any gaps or overlaps. The review will build on recent and ongoing work related to the Global Financial Safety Net and the Review of Program Design and Conditionality, ensuring the IMF maintains a robust, flexible, and well-communicated toolkit that supports the resilience of the GFSN and meets the evolving needs of its diverse membership.

     

     

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  • Telford Krazy Races soapbox derby off to a flying start – team spaces closing soon!

    Since the announcement, team spaces have been flying off the shelves. Locals, including friends, families, colleges, charities, and businesses of all sizes, have been quick to sign up, with over half of the 40 available team…

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  • Human assembloids recapitulate periportal liver tissue in vitro

    Human assembloids recapitulate periportal liver tissue in vitro

    Human specimens

    All human liver tissues used in this study were obtained after informed consent was obtained from patients undergoing operations at either the Department of Visceral, Thoracic and Vascular Surgery (VTG), University Hospital Carl…

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  • Astrocyte CCN1 stabilizes neural circuits in the adult brain

    Astrocyte CCN1 stabilizes neural circuits in the adult brain

    Animals

    All animal experiments were approved by the Salk Institute Institutional Animal Care and Use Committee (IACUC). Rats and mice were typically housed with a standard 12 h:12 h light:dark cycle in the Salk Institute animal facilities,…

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  • Lesion-remote astrocytes govern microglia-mediated white matter repair

    Lesion-remote astrocytes govern microglia-mediated white matter repair

    Mice

    Young adult male and female mice were used between 2 and 4 months of age at the time of experimental procedures. C57BL/6 J mice (JAX: 000664) were used for experiments requiring a wild-type background. For RNA-seq of astrocyte-specific…

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