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  • Death toll rises to 36 following an explosion, fire at India pharmaceutical factory

    Death toll rises to 36 following an explosion, fire at India pharmaceutical factory

    HYDERABAD, India — The death toll from Monday’s massive explosion and fire at a pharmaceutical factory in India’s southern state of Telangana has risen to at least 36 while about three dozen were left injured, authorities said Tuesday.

    The fire department recovered the charred bodies of 34 workers from the accident site in an industrial area about 50 kilometers (31 miles) from the state capital Hyderabad, the state’s fire services director G.V. Narayana Rao told The Associated Press.

    Two other workers succumbed to burns and were pronounced dead in hospital, Rao said, adding that debris of the gutted pharmaceutical unit of Sigachi Industries was still being removed to find out if any more workers were trapped.

    Nearly three dozen injured workers were admitted to hospitals, he said.

    “The whole structure of the factory has collapsed. Fire has been doused, and we hope to finish removing the debris in the next few hours,” Rao said.

    The explosion and subsequent fire was reported on Monday in the factory’s spray dryer unit, which is used to process raw material into fine powder for making drugs, Rao said.

    The state’s Health Minister Damodar Raja Narasimha said there were 108 workers inside the factory at the time of the explosion.

    “As bodies were badly burnt and mutilated, a special medical team has been deployed to conduct DNA tests”, said Narasimha, adding the state government has set up a panel to investigate the cause of the incident.

    Witnesses said they heard the explosion from a couple of kilometers away from the site.

    India is home to some of the world’s top pharmaceutical companies, playing a pivotal role in the global supply of generic medicines and vaccines. The country’s robust manufacturing and cost-effective production have made it a hub for pharma giants.

    Industrial accidents, particularly involving chemical reactors, aren’t uncommon in such factories, underlining the need for authorities to implement stringent safety protocols and regulatory oversight in a sector critical to public health.

    Sigachi Industries Limited is an Indian company dealing with active pharmaceutical ingredients, intermediates and vitamin-mineral blends, according to the company’s website. It has five manufacturing facilities across India and subsidiaries in the U.S and the United Arab Emirates.

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  • Virginia Tech studies ultrasound delivery of creatine for children with brain disorders

    Virginia Tech studies ultrasound delivery of creatine for children with brain disorders

    Researchers at Virginia Tech’s Fralin Biomedical Research Institute are developing a method to deliver creatine directly to the brain using focused ultrasound. The technique is being investigated as a potential intervention for children with creatine transporter deficiency, a condition that can impair speech, memory, and learning.

    Creatine plays a role in cellular energy production and neurotransmitter regulation, making it critical not only for muscle but also brain function. While oral supplements often improve muscle mass in patients with creatine deficiency, they do not consistently address neurological symptoms, in part because creatine has difficulty crossing the blood-brain barrier.

    “Creatine is very crucial for energy-consuming cells in skeletal muscle throughout the body, but also in the brain and in the heart,” says Chin-Yi Chen, a research scientist working on the project.

    Ultrasound delivery to bypass the blood-brain barrier

    The research is led by assistant professor Cheng-Chia “Fred” Wu, who studies therapeutic focused ultrasound, a noninvasive technique that uses sound waves to temporarily open the blood-brain barrier. The goal is to allow beneficial compounds, like creatine, to reach brain tissue without damaging surrounding cells.

    The project, supported by a $30,000 grant from the Association for Creatine Deficiencies, builds on Wu’s broader work using ultrasound to improve drug delivery for pediatric brain cancer. His collaboration with Dr. Seth Berger of Children’s National Hospital led to the idea of applying the same method to treat creatine deficiency.

    “Through the partnership between Virginia Tech and Children’s National Hospital, I was able to present our work in focused ultrasound at the Children’s National Research & Innovation Campus,” says Wu. “There, I met Dr. Seth Berger, a medical geneticist, who introduced me to creatine transporter deficiency. Together, we saw the promise that focused ultrasound had to offer.”

    Collaboration supports early-stage translational research

    Both Virginia Tech and Children’s National have been named Centers of Excellence by the Focused Ultrasound Foundation, a designation that supports collaborative research bridging lab studies and clinical applications. Chen’s initial work will focus on whether creatine can be successfully delivered across the blood-brain barrier and restore normal brain mass in lab models.

    “It was a moment that made me really excited — that I had found a lab where I could move from basic research to something that could help patients,” says Chin-Yi Chen. “When Fred asked me, ‘Are you interested in this project?’ I said, ‘Yes, of course.’”

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  • Usercentrics Report Reveals: As Concern Over Data Use Grows, Transparency Becomes the Number One Driver for Building Trust – Business Wire

    1. Usercentrics Report Reveals: As Concern Over Data Use Grows, Transparency Becomes the Number One Driver for Building Trust  Business Wire
    2. The Trust Deficit: Brand Transparency and the New Rules of Retail  Retail TouchPoints
    3. 4 Things Every B2B Brand Should Be Doing to Earn Trust in 2025  Entrepreneur
    4. The Future’s Powered by AI. Just Don’t Expect Everyone to Love It  Lifewire
    5. How trust became the new currency of brand growth  Fast Company

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  • Fitness coach shares what your diabetic parents need to eat daily: Millet khichdi, pumpkin seeds, tofu, berries, sprouts | Health

    Fitness coach shares what your diabetic parents need to eat daily: Millet khichdi, pumpkin seeds, tofu, berries, sprouts | Health

    Managing diabetes, especially high blood sugar, requires a healthy lifestyle and a well-balanced diet. However, when we continue to eat certain foods without understanding their impact on blood sugar levels, we may unknowingly make the condition worse. This is particularly important for older adults, who need to be mindful of what’s on their plate, as some common food choices can significantly elevate blood sugar and complicate diabetes management. Also read | Diabetes: Must-have foods to manage your blood sugar in summer

    5 foods, your parents must consume every day, if they are diabetic.(Freepik)

    Fitness coach Navneeth Ramprasad, on April 11, shared an Instagram post and explained how avoiding healthy foods can worsen diabetes in your parents. “If your parents are diabetic and you’re not giving them these 5 foods every day, be prepared to spend a lot more on medical bills in a few years, especially the last one. Let’s be real: Most Indian households are still eating the same food that made us the diabetes capital of the world,” Navneeth added.

    According to him, here are five foods that your parents must consume every day, if they are diabetic.

    1. Fresh coconut and almonds

    First thing in the morning, instead of tea or coffee. The healthy fats stabilise blood sugar, reduce morning crashes, and support brain health. Have 2 pieces of coconut and 5 soaked almonds. That’s it. Also read | Diabetes: 7 high-fibre foods that can prevent blood sugar spikes

    2. Oats, Greek yoghurt and berries

    For breakfast, instead of dosa, idly, or toast. Low GI carbs + protein + fiber + antioxidants = no sugar spikes and longer fullness.

    3. Millet khichdi, sprouts and cooked veggies

    For lunch, instead of white rice, sambar, and papad. Use foxtail millet or quinoa with moong dal, add steamed sprouts, and a bowl of high fiber veggies. Balanced plate = fiber, protein, slow carbs, and better post-lunch sugar control.

    4. Tofu or tempeh for dinner

    High-protein, low-carb, and essential for reversing insulin resistance. Add veggies, stir-fry or grill — just don’t end the day with wheat rotis alone.

    5. Pumpkin seeds, just before bedtime (9–9:30 PM)

    Prevents midnight sugar dips, supports sleep and magnesium levels. 1 small spoon (not more) of raw or lightly roasted seeds is perfect for diabetics who wake up tired or with sugar crashes at night. Also read | Smart eating for diabetes: Nutritionist-approved diet tips to keep your blood sugar in check

    Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.


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  • TV tonight: Jordan Gray’s cracking supermarket sitcom | Television

    TV tonight: Jordan Gray’s cracking supermarket sitcom | Television

    Transaction

    10.05pm, ITV2
    Jordan Gray is a cracking new comic talent and her first sitcom is full of zingers. Based on her YouTube videos, it follows a transgender woman, Olivia (Gray), who has been hired by the supermarket boss Simon (Nick Frost) to help save his reputation after an LGBTQ+ marketing faux pas. Lazy Olivia is well aware that this means she can get away with anything without getting fired – and this week she actually tries to get too-nice-to-be-true Millie (Francesca Mills) fired instead. Hollie Richardson

    The Traitors NZ

    8.05pm, BBC Three
    Even if you haven’t been following New Zealand’s second series of the hit reality competition franchise, it’s easy for fans of the show to get into the last week of episodes – with the final on Wednesday. Paul Henry is the charismatic host and there are plenty of big characters to up the drama. HR

    To Catch a Stalker

    9pm, BBC Three
    “Inflicting pure fear … how is that love?” Both episodes of Zara McDermott’s documentary air on Tuesday, telling the true stories of women who have been stalked by ex-partners and total strangers. It’s accessible but still petrifying – not least when McDermott meets Isobel, whose emergency escape plan involves jumping from the roof of her home. Hannah J Davies

    The Yorkshire Vet: At Home With the Greens

    9pm, Channel 5
    As farmer Steve’s 96th birthday looms, thoughts turn towards his faithful colleague of 70 years, Oddjob – a tractor that looks primed for the scrap heap. While specialist mechanics help with a surprise makeover, a trip to Thirsk market and a stray kitten at a local steel yard make it another gently busy week in North Yorkshire. Jack Seale

    10pm, Channel 4

    On the case … Emilia Fox and David Wilson. Photograph: Channel 4

    Emilia Fox once again joins the criminologist David Wilson and the detective Dr Graham Hill as this true crime series continues. This time, the brutal, unsolved 1991 murder of Vera Anderson is explored. Vera was found strangled in her car – but who dialled her number and caused her to leave her home so suddenly? Phil Harrison

    Storyville: The Srebrenica Tape

    10pm, BBC Four
    This deeply emotive personal story set against the mass horrors of the Bosnian war is told by Alisa, who possesses a VHS tape that her father filmed for her during the enclave years of Srebrenica. It sets her on a journey in search of her family’s history. HR

    Film choices

    The Hunger Games: The Ballad of Songbirds & Snakes (Francis Lawrence, 2023), Netflix

    Always singing … Rachel Zegler in The Hunger Games: The Ballad of Songbirds & Snakes Photograph: BFA/Alamy

    This needs to be said upfront: The Ballad of Songbirds & Snakes is a musical. Even though the film’s publicity really did not want you to know about it, this is a film in which Rachel Zegler will not stop singing. But forewarned is forearmed, and once the shock of the genre has worn off, what’s left might be the best Hunger Games movie yet. A prequel, this is an origin story for Coriolanus Snow (the authoritarian ruler played in previous movies by Donald Sutherland), so it gets to exist in the moral murk more happily than the rest of the series. Stuart Heritage

    The Damned United (Tom Hooper, 2009), 12am, BBC Two
    Long before The King’s Speech made him an A-lister (and even longer before Cats blew his career to smithereens), Tom Hooper made probably his best film. A wilfully inaccurate biopic of Brian Clough’s ill-fated stint as manager of Leeds United in 1974, the film is like a tug-of-war between a headstrong individual and an immovable corporation. It is truly fantastic, with Michael Sheen operating at the highest possible level as the cocky, obstinate Clough. A wonderful celebration of a complex man. SH

    Live sport

    Cricket: women’s international T20, England v India 6pm, Sky Sports Main Event. The second T20 in the five-match series from Bristol.

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  • Pakistan says at least 57 killed, 99 injured from monsoon rains since June 26

    Pakistan says at least 57 killed, 99 injured from monsoon rains since June 26


    ISLAMABAD: Pakistan’s benchmark KSE-100 Index rose by 60 percent during the outgoing fiscal year, a top brokerage firm said in its report this week, crediting the stock market’s impressive performance to macroeconomic stability, improved credit ratings and “aggressive” easing of the monetary policy. 


    Pakistan has undertaken a series of International Monetary Fund-recommended structural reforms and fiscal adjustments aimed at stabilizing the economy since it came to the brink of a sovereign default in 2023. These measures have led to increasing macroeconomic stability, reduced inflation and improved ratings from international credit agencies. 


    “Pakistan’s benchmark KSE-100 index is up 60 percent YoY in PKR terms and 57 percent in USD terms in FY25,” Topline Securities, a Karachi-based top brokerage firm, said on Monday. 


    The report said that over the past two fiscal years (FY24 and FY25), the PSX has recorded a total gain of 203 percent in terms of the Pakistani rupee and 206 percent in terms of the US dollar. It credited the Pakistan Stock Exchange’s (PSX) rise to macroeconomic stability achieved by the country after it secured a $7 billion International Monetary Fund’s (IMF) loan program. 


    Topline Securities said other factors contributing to the “remarkable rally” at the stock market are the completion of the IMF’s first review by Pakistan in March, the central bank’s “aggressive” monetary easing from 20.5 percent to 11 percent, and improvement in the country’s credit rating by Fitch from CCC+ to B-.


    “As per Bloomberg data, Pakistan’s market was the 8th best performer in FY25 with a total USD return of 57 percent,” the report said. “However, over the cumulative two-year period (FY24 and FY25), it ranked as the best-performing market in the world.”


    The report noted that average traded volumes in the cash/ready market increased by 37 percent YoY to an average of 631 million shares per day during FY25, adding that the average traded value also jumped by 80 percent YoY to Rs28 billion per day.


    The report warned Pakistan may face pressure in achieving its revenue targets for FY26 but said it expected the government to pass the IMF’s program reviews in a timely manner by meeting the lender’s objectives. This, the report said, Islamabad would achieve through cutting development and other non-essential expenditures.


    Topline Securities said it also expected a credit rating upgrade for Pakistan in the current fiscal year.


    “The rating upgrade in our view is quite likely as debt ratios and FX reserves are showing improvements,” the report said. “With the credit rating upgrade to ‘B’ category, Pakistan may resort to the international bond market by issuing Eurobond and Sukuks which will further support FX reserves and strengthen the debt maturity profile of the country,” it added. 


    The report pointed out that any developments in Pakistan–US relations under President Donald Trump’s administration, along with regional tensions, could “significantly influence market sentiment.”


    “Currently, a ceasefire is in place between India and Pakistan; however, any escalation could negatively affect investor confidence,” it said.


    It also warned that any further conflict in the Middle East is likely to have broader macroeconomic implications for Pakistan amidst its dependency on oil imports, which could then weigh on the stock market’s performance.

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  • BCG Revaccination Fails to Prevent Sustained TB Infection

    BCG Revaccination Fails to Prevent Sustained TB Infection

    TOPLINE:

    Bacille Calmette-Guérin (BCG) revaccination showed no efficacy in preventing sustained Mycobacterium tuberculosis infection compared with placebo in adolescents, with similar rates of QuantiFERON-TB (QFT) test conversion from negative to positive.

    METHODOLOGY:

    • In a previous trial, BCG revaccination did not prevent primary M tuberculosis infection but did reduce the risk for sustained infections, prompting further study in a wider population.
    • Researchers conducted a phase 2b, randomized study to evaluate the efficacy of BCG revaccination for the prevention of sustained M tuberculosis infection in South Africa.
    • A total of 1836 adolescents (age, 10-18 years), who tested negative for HIV and had negative QFT test results at screening, were randomly assigned to receive either the BCG vaccine or placebo and were followed up for a median of 30 months.
    • A sustained M tuberculosis infection was defined as a sustained QFT test conversion from negative to positive (≥ 0.35 IU/mL interferon gamma), occurring any time after the first negative QFT test, followed by positive tests confirmed at 3 and 6 months.
    • The primary endpoint was sustained QFT test conversion, and the secondary endpoints were the safety and reactogenicity of BCG revaccination.

    TAKEAWAY:

    • BCG revaccination showed no protective effect against sustained M tuberculosis infection, with similar QFT test conversion rates in the vaccine and placebo groups (hazard ratio, 1.04; P = .58), with a vaccine efficacy of -3.8% (95% CI, -48.3 to 27.4).
    • The frequencies of antigen-specific CD4 T cells expressing various cytokines were higher in the BCG revaccination group than in the placebo group, and they remained higher than those at baseline even 6 months postvaccination.
    • Most adverse events were mild to moderate. Serious adverse events occurred in 0.3% of participants in each group and were unrelated to the vaccine or placebo, with no deaths or treatment discontinuations.

    IN PRACTICE:

    “Although this trial does not allow us to draw firm conclusions on the efficacy of BCG revaccination for the prevention of disease, the lack of vaccine efficacy with respect to prevention of infection probably decreases the likelihood of BCG revaccination conferring protection against disease,” the study authors wrote.

    SOURCE:

    The study was led by Alexander Schmidt, MD, Gates Medical Research Institute, Cambridge, Massachusetts. It was published online on May 7, 2025, in The New England Journal of Medicine.

    LIMITATIONS:

    Enrollment was paused for 4 months due to the COVID-19 pandemic, which may have contributed to a lower incidence of QFT test conversions.

    DISCLOSURES:

    The study was supported by the Gates Foundation. One author reported being an employee of the Gates Medical Research Institute. Some authors reported being employees of pharmaceutical companies such as GSK, Pfizer, and Third Rock Ventures, LLC, and owning stocks in these companies.

    This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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  • Godiva Festival brings back local talent stage after cash boost

    Godiva Festival brings back local talent stage after cash boost

    A third stage to showcase more local musicians will return to a Coventry music festival, enabling it to also celebrate its twin city of Kingston, Jamaica.

    The Cov ConneX Kingston Stage will be back at the Godiva Festival after organisers secured funding worth almost £30,000 from National Lottery through Arts Council England.

    Around 40 city-based artists will take to the stage over the weekend with styles ranging from rap, grime, afrobeat and reggae to DJs and MCs, all about celebrating local inspiration alongside the sounds of Jamaica.

    Councillor Abdul Salam Khan said the stage’s return will add “something extra special and I know it will be a big attraction for all music lovers”.

    The headliners this year have been confirmed as Marc Almond, Clean Bandit and Ocean Colour Scene.

    Staged in Coventry’s War Memorial Park the council-organised festival runs from Friday until Sunday.

    A second stage, called the Cov Stage, will also host local talent.

    Councillor Naeem Akhtar described Coventry as a “great musical city.”

    “Godiva is loved by so many, and with the music stages supported by a host of other attractions for families and visitors of all ages, it’s going to be another memorable weekend for the city,” he said.

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  • Irrigation Department issued timely warnings ahead of Swat flashflood, reveals report

    Irrigation Department issued timely warnings ahead of Swat flashflood, reveals report

    People can be seen stranded in the middle of the Swat River on June 27, 2025, in this still taken from a video. — Instagram/@geonewsdottv
    • Report says alerts were sent multiple times to DCs, PDMA.
    • Dept recommends providing flood rescue equipment to Rescue 1122.
    • It suggests developing policy to confine tourists to safe areas.

    PESHAWAR: As the concerns regarding the tragic death of 12 people by drowning in the Swat River due to a deluge grow, worrisome reports of official negligence continue to emerge. 

    A departmental probe revealed that the Khyber Pakhtunkhwa irrigation department had issued multiple warnings to relevant organisations and the deputy commissioners of Swat, Charsadda, and Nowshera just hours before a flash flood in the Swat River that lead to the loss of precious lives.

    The tragedy occurred when 17 members of a family from Sialkot were swept away by a sudden surge in the river while picnicking on a mound near the bank. Disturbing videos circulating on social media showed the family stranded on a rapidly shrinking patch of land, crying out for help for nearly an hour, with no immediate rescue response.

    So far, 12 bodies have been recovered, including that of a child found in Charsadda on Sunday. Search is still underway as one person remains missing.

    The report stated that the river’s flow at Khwazakhela spiked dramatically from 6,738 cusecs to 77,782 cusecs within a few hours on June 27. The first warning was issued at 8:41am, alerting all concerned authorities — including the deputy commissioners of Swat, Charsadda, and Nowshera — of the potential flood risk.

    The department continued to send real-time updates through WhatsApp and issued a severe flood warning by 10:30am. Repeated alerts were sent to the DCs, the Provincial Disaster Management Authority (PDMA), ADC Relief, and other relevant bodies, indicating that the department had issued timely and comprehensive warnings.

    According to the report, tourists at Khwazakhela had entered the river when water levels were still normal but became trapped as the flow rose sharply due to heavy rainfall. 

    It also noted that silt accumulation in the riverbed since 2022 has made it easier for visitors to wade deeper into the stream, increasing the risk during sudden surges.

    In its recommendations, the Irrigation Department suggested equipping Rescue 1122 with flood rescue gear, restricting access to tourist areas, and holding hotel owners accountable for allowing visitors into hazardous zones. 

    It also proposed that local administrations develop a policy to confine tourists to safe areas and recommended the installation of additional telemetry gauges in Madyan and Kalam to enhance monitoring of river levels.

    Failures in oversight, rescue efforts

    The rescue services has also come under fire after the Swat River tragedy. Despite being stationed just 3 to 4 kilometres from the site, Rescue 1122 teams reportedly took 19 minutes to arrive and were ill-equipped, lacking boats, ropes, and trained divers. Equipment had to be ordered during the operation, arriving too late to make a meaningful difference.

    Additionally, attention has turned to encroachments along the riverbank. Critics have questioned how structures were allowed to be built within 200 feet of the river, in violation of safety regulations.

    Although the government has since launched a crackdown on such illegal constructions, there are calls for accountability against the officials who issued no-objection certificates (NOCs) and building permits.

    Observers stress that for the operation to be effective and accepted by the public, it must be carried out without bias, regardless of the socioeconomic or political status of those affected.

    In response to the incident, the Khyber Pakhtunkhwa government has imposed a complete ban on mining along riverbeds and initiated a province-wide operation to remove illegal structures.

    The authorities are now under increased pressure to address the systemic issues that contributed to the deadly incident and to implement reforms that prioritise safety and accountability.


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  • Liquorland links up as official supplier for 2025 British & Irish Lions Tour

    Liquorland links up as official supplier for 2025 British & Irish Lions Tour

    Rugby fans across Australia are set to score, with Liquorland confirmed as Official Supplier
    of the 2025 British & Irish Lions Tour and the Wallabies.

    The tour kicked off on Saturday in Perth, marking the Lions’ first visit to Australia in 12
    years, with matches to cover ground in eight cities and more than 40,000 international
    fans expected to visit across the country.

    Rugby Australia CEO Phil Waugh said the Lions Tour is building into a huge national
    moment and Liquorland’s sponsorship has got fans covered for game-day cheers.

    “The British & Irish Lions Tour is going to be a massive event across six cities with packed
    stadiums, and fans flying in from all over. There’s nothing quite like a Lions Tour, and we’re
    excited to see the whole country get behind it.”

    “Having Liquorland on board adds to the momentum and energy. It’s great to see them
    backing the Wallabies and helping fans get in the spirit of the game particularly as the
    wider support for rugby across the country continues to grow.”

    Coles Liquor General Manager of Customer Loyalty Mia Horner said the team was proud
    to be part of the action celebrating the world’s biggest and most in-demand rugby tour.

    “We’re incredibly excited to be part of the tour and take up this once in every 12-year
    opportunity. It’s a bucket-list moment for fans from abroad to join the Lions tour and we
    can’t wait to welcome them down under,” she said.

    “We’ve lined up a cracking offer to help international fans find their local away from home
    with Liquorland and score great deals and money off their in-store shop through our
    partnership with SEN.”

    The British & Irish Lions Tour of Australia 2025

    Western Force v British & Irish Lions at 5:45pm AWST on Saturday 28 June at Optus
    Stadium, Perth

    Queensland Reds v British & Irish Lions at 7:45pm AEST on Wednesday 2 July at Suncorp
    Stadium, Brisbane

    New South Wales Waratahs v British & Irish Lions at 7:45pm AEST on Saturday 5 July at
    Allianz Stadium, Sydney

    ACT Brumbies v British & Irish Lions at 7:45pm AEST on Wednesday 9 July at GIO Stadium,
    Canberra

    AUNZ Invitational XV v British & Irish Lions at 7:15pm ACST on Saturday 12 July at Adelaide
    Oval, Adelaide

    Wallabies v British & Irish Lions at 7:45pm AEST on Saturday July 19 at Suncorp
    Stadium, Brisbane

    First Nations & Pasifika XV v British & Irish Lions at 7:45pm AEST on Tuesday 22 July at
    Marvel Stadium, Melbourne

    Wallabies v British & Irish Lions at 7:45pm AEST on Saturday July 26 at Melbourne
    Cricket Ground, Melbourne

    Wallabies v British & Irish Lions at 7:45pm AEST on Saturday August 2 at Accor
    Stadium, Sydney


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