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  • Diagnostic Performance of Ultrasound vs Ultrasound-Guided FNAC in Thyroid Nodules

    Diagnostic Performance of Ultrasound vs Ultrasound-Guided FNAC in Thyroid Nodules

    Hisham Mehanna, Paul Nankivell, Kristien Boelaert, Rebecca Woolley, Neil Sharma, Paul S Sidhu, Gitta Madani, Philip Da Forno, Catherine Moreman, Andrew Palmer, Tessa Fulton-Lieuw, Judith Taylor, Kanchana Rajaguru, Jasper Bekker, Ram Vaidhyanath, Thaj Rehman, Jon Deeks
    The Journal of Clinical Endocrinology & Metabolism, Volume 110, Issue 7, July 2025, Pages 1997–2006
    https://doi.org/10.1210/clinem/dgae682

    Abstract

    Introduction

    ElaTION is a large multicenter pragmatic randomized controlled trial, performed in 18 secondary/tertiary hospitals across England, comparing elastography ultrasound-guided fine needle aspiration cytology (EUS-FNAC) with ultrasound-guided FNAC (US-FNAC) alone in the diagnostic assessment of thyroid nodules. Secondary trial outcomes, reported here, assessed the accuracy of ultrasound alone (US) compared with US-FNAC to inform and update current practice guidelines.

    Methods

    Adults with single or multiple thyroid nodules who had not undergone previous FNAC were eligible. Radiologists assessed all thyroid nodules using US alone, thereby enabling assessment of its accuracy (sensitivity and specificity) vs US-FNAC.

    Results

    Of the 982 participants, a final definitive diagnosis was obtained in 688, who were included in the final analyses. The sensitivity of US alone was the same as US-FNAC (0.91 [95% CI, 0.85–0.97] vs 0.87 [95% CI, 0.80–0.95] P = .37). US alone had statistically significant lower specificity than US-FNAC alone (0.48 vs 0.67 respectively, P < .0001). The malignancy rate on histology in a nodule classified as benign on ultrasound (U2) was 9/263 (3.42%) and on cytology (Thy2) was 15/353 (4.25%), whereas the malignancy rate in a nodule that was benign on both (U2, Thy2) was 3/210 (1.43%). Malignancy risk for U3, U4, and U5 nodules was 68/304 (22.4%), 43/83 (51.8%), and 29/38 (76.3%), respectively (P < .0001). Yet 80/982 (8%) patients were discharged despite having U3-U5 scans with Thy1 (nondiagnostic) FNAC and no definitive diagnosis.

    Malignancy risk was higher in smaller nodules: < 10 mm 23/60 (38.3%), 10–20 mm 46/162 (28.4%), and >20 mm 80/466 (17.2%) (P < .0001). Nodules with indeterminate cytology with atypical features (Thy3a) carried a similar malignancy risk to those with indeterminate cytology (Thy3/3f): 27/95 (28.4%) vs 42/113 (37.2%) respectively (P = .18).

    Conclusion

    Ultrasound alone appears to be an effective diagnostic modality in thyroid nodules, confirming the recommendations of recent guidelines and the British Thyroid Association classification. However, findings also suggest caution regarding existing recommendations for conservative management of nondiagnostic (Thy1/Bethesda I) and atypical (Thy3a/Bethesda III) nodules. In those cases, ultrasound (U3–U5) features may help identify high-risk subgroups for more proactive management.

     

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  • Lowkey Films Becomes First Feature Film Company To Earn B Corp Status

    Lowkey Films Becomes First Feature Film Company To Earn B Corp Status

    EXCLUSIVE: Lowkey Films, the British indie behind the 2023 feature Kindling, has earned a B Corp certification.

    The company, led by Jamie Gamache and Connor O’Hara, is the first production company working on feature films to receive the certification, which assesses a company’s operations and designates businesses that are socially and environmentally conscious. High-profile companies with the certification include Ben & Jerry’s, Patagonia, Aesop, Allbirds, and The Body Shop. 

    The B Corp process is rigorous and requires companies to meet high standards of social and environmental performance, which is achieved by completing the B Impact Assessment and passing a thorough review and verification process.

    “For instance, there’s the legal element where we had to change the Articles of Association on Companies House to say that our business will act in the interests of all stakeholders, rather than just the shareholders,” Gamache explained of the 18-month process. “There are also things like we have to track our carbon footprint and make sure we offset that every year. We have to prove that we have a breastfeeding policy in the office. These are things that make such a massive difference to our staff and crew that are just never spoken or thought about.”

    Gamache and O’Hara added that the certification won’t only shape their business practices but also their creative production, and they hope to inspire other companies to also take the step and move away from what they described as the “Kubrickian” mode of “work until you drop.”

    “Our experience is that a project has never benefited from that way of working. That’s when things go wrong and people get hurt,” O’Hara said. “Everyone talks about sustainability primarily about the environment, but B Corp prioritizes sustainability for the people as well. It’s about looking at how we can sustain a work-life balance and workflow and have, for instance, a three-month shoot where everything is safe and well practiced for all those involved.” 

    There are four members of the core Lowkey team, and they scale up their workforce using freelancers when working on projects. The company works across film, documentaries, commercials, and music projects. This month, they debuted a live music project with Dua Lipa alongside Salvable, a feature drama they produced starring Toby Kebbell and Shia LaBeouf, which will be released in the UK this month following a U.S. release via Lionsgate. Kindling, their first feature, was released in the UK by Signature Entertainment in 2023 and by Byron Allen’s Freestyle Digital Media in the U.S.

    Kindling put us on the map,” O’Hara said. “We’ve now got three films lined up to shoot in the next 18 months. And alongside that, a documentary slate and a documentary TV series.”

    One of those projects is Arctic Skies, starring Morfydd Clark (The Lord of the Rings: The Rings of Power) and Ariyon Bakare (His Dark Materials). The sci-fi-thriller, inspired by one of the most well-documented UFO encounters on record, follows the harrowing journey of a cargo plane crew who, while flying at 40,000 feet above the Arctic Circle, become the target of otherworldly attention. The film will be shot at Steven Knight’s Digbeth Loc Studios in Birmingham.

    Next month, the company will also complete production on a short project commissioned as part of No Drama, a development project led by Jordan Peele’s Monkeypaw Productions, Universal, and TIFF. The initiative selects five filmmakers to create a short film or proof of concept for a feature that explores horror across cultures, time, environments, and society. The projects will be presented at TIFF 2025.

    “We were the only UK filmmakers selected as part of the initiative, which we take a lot of pride in as it aligns with our international aspirations,” O’Hara said. “We’re working with a director called Charlie Dennis. And the project is a horror that looks at the UK class system and is all set in Birmingham.”

    O’Hara added: “We finish it in a month, and then fly to TIFF.” 

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  • Towering ambition: the Swiss artist Not Vital’s Alpine playground – The Art Newspaper

    Towering ambition: the Swiss artist Not Vital’s Alpine playground – The Art Newspaper

    High on a hill in the Swiss Alpine region of Engadin sits Schloss Tarasp, an impressive castle thought to have been built in 1040. The fortress has changed ownership over the centuries. It belonged to the Count of Tyrol in the 13th century, later becoming part of an Austrian enclave and then of the short-lived Helvetic Republic in 1803, before passing through a series of private hands. Today, Schloss Tarasp is owned by the multidisciplinary Swiss artist Not Vital, who grew up in nearby Sent and bought this historic mountain retreat in 2016. The castle is part of a foundation—which also oversees a sculpture park, Parkin Sent, and the 17th-century Planta House Ardez—which the artist set up to preserve culture in the region by uniting art, nature and architecture.

    Vital came onto the art scene in the late 1970s and 1980s in New York City and has since earned international recognition, exhibiting in both the art and architecture editions of the Venice Biennale. Working in disciplines that include painting, drawing and sculpture, he is best known for what he calls SCARCH—his humorous and sometimes enigmatic sculpture-architecture hybrids that blur the boundaries between the two. Vital moves often between Rio de Janeiro, Beijing and Sent, living a relatively nomadic life.

    Vital established his artistic foothold in the Engadin region in southeastern Switzerland in 1998 when he bought Parkin Sent. Originally laid out in the early 20th century to house a private villa, the park had all the accoutrements of a luxurious retreat—a pool, luscious walking paths and a terrace—but the Second World War forced the then owner to abandon the plan. When Vital bought the park, he and his brother revived the overgrown land and began installing Vital’s artwork. In the early 2000s, the artist bought nearby Planta House Ardez, a house dating from 1642, and turned it into the headquarters of his foundation. The house contains a library of books in Romansch (the minority Swiss language) and hosts rotating exhibitions of modern and contemporary art, open to visitors each August.

    A sense of playfulness

    Parkin Sent is home to several outdoor installations by Vital that encourage visitors to explore the forests and rugged terrain, engaging with nature as they search for each artwork. Open seasonally (Fridays from mid-June to early October), the park includes Punt dals asens (Donkey Bridge) (2001), an installation of aluminium donkey heads on narrow vertical beams, the heads getting higher off the ground as the land below slopes downward. Brave visitors can walk along the pathway while holding rails on either side of them. Playing with perception is another bridge, simply called Bridge (2008), which is inconspicuous and vanishes into the forest, its stainless steel surfaces reflecting the surrounding environment. While the bridge only appears to be invisible, JOSÜJO (Disappearing House) (2007) takes a more literal approach. Resembling a triangle with a grass-covered roof, the structure descends into the ground at the push of a button.

    Not Vital’s House to Watch the Sunset (2018) is installed in the landscape surrounding Schloss Tarasp

    Photo: Eric Powell

    With his purchase of Schloss Tarasp, Vital deepened his connection to Engadin. The castle’s interior is both a time capsule of its previous lives and a home to modern and contemporary art—his own and that of fellow artists such as Rirkrit Tiravanija and George Condo. The land surrounding the castle gave Vital additional opportunities to display his sculptures. Here, in 2018, he installed a version of one of his best-known projects, House to Watch the Sunset, an ongoing installation that he began in 2005 in Niger. The tower-like piece resembles architecture, but is stripped of its function—it contains no utilities and defies logic in its construction. Thirteen metres high, the structure has external staircases leading from the ground to each floor, yet none is accessible via another. To climb the tower, visitors have to ascend and descend one set of stairs, turn the corner and climb another to reach the next level. A door adorns every floor, but the number of windows increases by the floor—one on the first, two on the second and three on the third.

    Additional pieces by Vital are scattered across the grounds, including several stainless steel sculptures, such as Camel (2018), a giant camel head below the hill with impressive views of the castle high above, and Tongue (2010), a playful, totemic tongue installed closer to the building, all of which can be visited seasonally with a guided tour.

    Vital’s JOSÜJO (Disappearing House) (2007) at his Parkin Sent sculpture park

    Photo: Eric Powell

    Vital is planning to construct a version of House to Watch the Sunset on every continent. For each iteration, he chooses materials in response to the work’s location. For the installation in Niger, Vital used mud and straw, while the Schloss Tarasp version is made of concrete and local sand. Other locations follow a similar trend, including local woods in the installation in Brazil near the Amazon. House to Watch the Sunset is emblematic of Vital’s SCARCH works. Although the piece lacks the infrastructure to function as a house, it does fulfil the second part of its title, providing stunning vantage points to watch the sunset. And, at least at Schloss Tarasp, the work takes on an additional purpose as a watchtower to overlook Vital’s poetic, creative reach across the Engadin region.

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  • PM appoints Qatari princess as brand ambassador after she scales Nanga Parbat – Pakistan

    PM appoints Qatari princess as brand ambassador after she scales Nanga Parbat – Pakistan

    Prime Minister Shehbaz Sharif on Tuesday appointed Qatari mountaineer and royal family member Sheikha Asma Al Thani as the brand ambassador for Pakistan’s mountains and tourism after she recently successfully summited Nanga Parbat, the ninth-highest mountain on Earth located in Gilgit-Baltistan region.

    Known as the “Killer Mountain,” the 8,126-metre-high peak is considered one of the world’s most dangerous climbs due to its severe weather conditions and rough terrain.

    In a post on X, the premier felicitated Sheikha Asma on the achievement.

    “I am pleased to appoint Her Highness Sheikha Asma Al Thani as the Brand Ambassador for Pakistan’s mountains and tourism.

    “My heartfelt felicitations to Her Highness on her recent feat of scaling Nanga Parbat. It is truly inspiring,” he wrote.

    “Her achievement sends a powerful message of courage and determination, and stands as a testament to the enduring friendship between Pakistan and Qatar,” he added.

    In a post on Instagram, Sheikha Asma described the relentless challenges she faced on her route to the summit and the emotional toll of the ascent.

    “My ninth 8000er and one of the toughest climbs I’ve faced. This mountain tested me in ways I didn’t expect, from black ice beneath my feet to rockfall every few seconds. A constant reminder of how fragile life truly is,” she wrote.

    “But even in that danger, there was growth. There was surrender and there was strength I didn’t know I still had. I climb not just to reach summits but to return to what matters, to strip away the noise and reconnect with myself,” she added.

    “This mountain will stay with me forever.”

    Sheikha Asma hoisted Qatar’s national flag at the summit and becomes the first Qatari woman to do so. Her earlier summits include Mount Everest, K2 and Makalu.

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  • Junior Boks call up Felix as they prepare for Scots

    Junior Boks call up Felix as they prepare for Scots

    Ndlozi, who scored two tries in their pool opener against Australia, sustained a hamstring injury against England on Friday, which has ruled him out of the rest of the tournament.

    Felix, who played for the SA Schools team in 2024, had a good FNB Varsity Cup campaign, and was part of the wider Junior Bok squad prior to their departure for Italy.

    With one pool game to go before the semi-finals, the Junior Boks are fully aware of the huge threat posed by Scotland when they meet at the Stadio San Michele in Calvisano on Wednesday. Kick-off is at 15h30 and the match will be televised live on SuperSport Rugby.

    With just five days between matches, and with two more games to come after Wednesday’s pool decider, both sides have made changes to their match squads.

    The Junior Boks have picked a strong starting fifteen stacked with players who have already donned the green and gold jersey during their tour of Georgia, the U20 Rugby Championship, and warm-up games against Kenya. The bench includes several players who participated in the victories over Australia and England in Italy.

    Meanwhile, Scotland have made nine changes to their starting line-up, meaning they will come at the Junior Boks with fresh legs and huge determination to challenge the South Africans from the outset.

    Alzeadon Felix in action in the U18 International Series last year.

    Thando Biyela, who captained the Junior Boks against Georgia and will lead the side against Scotland, said he will be leaning on the experienced players around him during the game.

    “It is a massive honour to be leading the Junior Springboks, but I have such experienced players around me, such as Vusi Moyo and Jaco Grobbelaar, and also Haashim Pead on the bench,” said Biyela.

    “We will be looking to maintain our momentum, but the Scots are a big and physical unit so it’s going to be an exciting battle. For us, it will be about getting clarity on all the things we are doing and focusing on our set piece to set up a good attacking platform.”

    Lumumba Currie, the Junior Springboks’ forward coach, echoed head coach Kevin Foote’s view that their performances thus far are the result of the squad’s hard work during their preparation back home in Stellenbosch.

    “We went to Georgia, and one of the big areas we focused on was getting the set piece right,” said Currie.

    “Then, to gain more experience, we trained against senior provincial players and against Kenya, so we took confidence from those camps leading up to the tournament. Our forwards have done well so far, but we did concede some penalties, so we have been working hard to eliminate our mistakes.

    “As a South African team, we want to impose ourselves on the opposition, but we know Scotland are a good set-piece team with a big pack of forwards and good plans, so we must be prepared for them.”

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  • ‘Ice in a volcano’ reveals age of gas cloud at Milky Way’s center

    ‘Ice in a volcano’ reveals age of gas cloud at Milky Way’s center

    ‘Ice in a volcano’ reveals age of gas cloud at Milky Way’s center

    by Tracey Peake for NCSU News

    Raleigh, NC (SPX) Jul 08, 2025






    Researchers have found clouds of cold gas embedded deep within larger, superheated gas clouds – or Fermi bubbles – at the Milky Way’s center. The finding challenges current models of Fermi bubble formation and reveals that the bubbles are much younger than previously estimated.



    “The Fermi bubbles are enormous structures of hot gas that extend above and below the disk of the Milky Way, reaching about 25,000 light years in each direction from the galaxy’s center – spanning a total height of 50,000 light years,” says Rongmon Bordoloi, associate professor of physics at North Carolina State University and corresponding author of the research.



    “Fermi bubbles are a relatively recent discovery – they were first identified by telescopes that ‘see’ gamma rays in 2010 – there are different theories about how it happened, but we do know that it was an extremely sudden and violent event, like a volcanic eruption but on a massive scale.”



    Bordoloi and the research team used the U.S. National Science Foundation Green Bank Telescope (NSF GBT) to observe the Fermi bubbles and get high resolution data about the composition of the gas within and the speed at which it is moving. These measurements were twice as sensitive as previous radio telescope surveys of the Fermi bubbles and allowed them to observe finer detail within the bubbles.



    Most of the gas inside the Fermi bubbles is around 1 million degrees Kelvin. However, the research team also found something surprising: dense clouds of neutral hydrogen gas, each one measuring several thousand solar masses, dotted within the bubbles 12,000 light years above the center of the Milky Way.



    “These clouds of neutral hydrogen are cold, relative to the rest of the Fermi bubble,” says Andrew Fox, ESA-AURA Astronomer at the Space Telescope Science Institute and coauthor of the paper.



    “They’re around 10,000 degrees Kelvin, so cooler than their surroundings by at least a factor of 100. Finding those clouds within the Fermi bubble is like finding ice cubes in a volcano.”



    Their existence is surprising because the hot (over 1 million degrees Kelvin), high-velocity environment of the nuclear outflow should have rapidly destroyed any cooler gas.



    “Computer models of cool gas interacting with hot outflowing gas in extreme environments like the Fermi bubbles show that cool clouds should be rapidly destroyed, usually within a few million years, a timescale that aligns with independent estimates of the Fermi bubbles’ age,” Bordoloi says. “It wouldn’t be possible for the clouds to be present at all if the Fermi bubbles were 10 million years old or older.



    “What makes this discovery even more remarkable is its synergy with ultraviolet observations from the Hubble Space Telescope (HST),” Bordoloi says. “The clouds lie along a sightline previously observed with HST, which detected highly ionized multiphase gas, ranging in temperatures from a million to 100,000 Kelvin – which is what you’d expect to see if a cold gas is getting evaporated.”



    The team was also able to calculate the speed at which the gases are moving, which further confirmed the age.



    “These gases are moving around a million miles per hour, which also marks the Fermi bubbles as a recent development,” Bordoloi says. “These clouds weren’t here when dinosaurs roamed Earth. In cosmic time scales, a million years is the blink of an eye.”



    “We believe that these cold clouds were swept up from the Milky Way’s center and carried aloft by the very hot wind that formed the Fermi bubbles,” says Jay Lockman, an astronomer at the Green Bank Observatory and coauthor of the paper. “Just as you can’t see the motion of the wind on Earth unless there are clouds to track it, we can’t see the hot wind from the Milky Way but can detect radio emission from the cold clouds it carries along.”



    This discovery challenges current understanding of how cold clouds can survive the extreme energetic environment of the Galactic Center, placing strong empirical constraints on how outflows interact with their surroundings. The findings provide a crucial benchmark for simulations of galactic feedback and evolution, reshaping our view of how energy and matter cycle through galaxies.



    Research Report:A New High-latitude H I Cloud Complex Entrained in the Northern Fermi Bubble


    Related Links

    North Carolina State University

    Stellar Chemistry, The Universe And All Within It


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  • Crystalline grains found in space ice challenge assumptions about its structure

    Crystalline grains found in space ice challenge assumptions about its structure

    Crystalline grains found in space ice challenge assumptions about its structure

    by Sophie Jenkins

    London, UK (SPX) Jul 08, 2025






    Ice commonly found in space is not entirely amorphous, as long believed, but instead contains nanoscale crystals, according to a new study by scientists at University College London (UCL) and the University of Cambridge. The findings revise long-held views about low-density amorphous ice, which forms under extremely cold conditions in comets, icy moons, and interstellar dust clouds.



    The research team used computer simulations and experimental methods to investigate the atomic-level structure of this widespread cosmic ice. Simulations showed the ice’s properties best matched experimental data when up to 25% of it was crystalline, consisting of crystals about three nanometres across embedded within an otherwise disordered matrix.



    By warming real samples of low-density amorphous ice created via various methods, researchers found that the resulting crystal structure varied depending on how the ice initially formed. This retention of structural memory indicates the ice was never fully amorphous to begin with.



    Lead author Dr Michael B. Davies explained, “We now have a good idea of what the most common form of ice in the Universe looks like at an atomic level. This is important as ice is involved in many cosmological processes, for instance in how planets form, how galaxies evolve, and how matter moves around the Universe.”



    The presence of crystalline regions also has implications for theories about the origin of life. One such idea, Panspermia, suggests life’s building blocks arrived on Earth embedded in space ice. However, Davies noted that partially crystalline ice offers less internal space to trap and transport these molecules. “The theory could still hold true, though, as there are amorphous regions in the ice where life’s building blocks could be trapped and stored,” he added.



    Professor Christoph Salzmann, a co-author from UCL Chemistry, remarked, “Our findings show [ice in space] is not entirely a snapshot of liquid water. Our results also raise questions about amorphous materials in general,” pointing to potential improvements in fiber optics and other technologies if these insights into structural disorder can be applied.



    The team created their simulations by cooling virtual boxes of water to -120 degrees Centigrade at different rates, observing that slower cooling allowed some crystallization. In separate trials, they simulated clusters of small ice grains with disordered boundaries, reaching similar structures. Real-world samples of amorphous ice were produced using methods like vapor deposition on cold surfaces or compressing and warming other ice forms.



    These investigations revealed subtle differences in hexagonal molecular arrangements after crystallization, reinforcing the presence of crystalline components. The researchers now seek to understand whether a truly amorphous ice can exist and how its structure depends on formation conditions.



    First identified in the 1930s and further characterized in later decades, amorphous ices now include low-, high-, and medium-density varieties. The medium-density form, discovered in 2023 by the same UCL-Cambridge team, matches the density of liquid water.



    “Water is the foundation of life but we still do not fully understand it,” said co-author Professor Angelos Michaelides. “Amorphous ices may hold the key to explaining some of water’s many anomalies.”



    Dr Davies added that knowing the properties of ice is also crucial for space technology. “It could shield spacecraft from radiation or provide fuel in the form of hydrogen and oxygen,” he said.



    Research Report:Low-density amorphous ice contains crystalline ice grains


    Related Links

    University College London

    Stellar Chemistry, The Universe And All Within It


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  • Bioiberica’s hyaluronic acid-based nutricosmetic makes the skin ‘glow’, study reveals

    Bioiberica’s hyaluronic acid-based nutricosmetic makes the skin ‘glow’, study reveals

    A new study has touted the anti-ageing and skin health-boosting effects of Bioiberica’s hyaluronic acid matrix ingredient, Dermial.


    With a high concentration of hyaluronic acid (>60%), collagen and a balance of other glycosaminoglycans (GAGs) including dermatan sulfate, Dermial is the first hyaluronic acid matrix ingredient on the market, according to Bioiberica.


    To assess the efficacy of Dermial as a nutricosmetic, the company performed a 12 week, randomised, double-blind, placebo-controlled clinical trial with 60 healthy female participants aged between 35 and 65 — all of which had visible signs of skin ageing.


    Published in Dermatology and Therapy, results revealed that daily supplementation with 60mg of Dermial can enhance skin hydration and reduce the appearance of facial wrinkles.1


    This suggests that hyaluronic acid, and specifically Dermial, could offer significant beauty from within benefits when taken daily.


     


    Beauty isn’t skin deep


    Hyaluronic acid has long been a staple of the cosmetics industry, with a vast number of topical products on the market utilising the super-ingredient to promote skin health and vitality.


    However, when applied topically, the ingredient can only achieve surface-level hydration, which doesn’t address dryness at a cellular level. (For more information on the rise of beauty from within ingredients, check out this interview with Tosla Nutricosmetics’ Monika Jesenko.)


    To overcome this issue, nutraceutical suppliers in both the joint health and beauty from within spaces have begun formulating with hyaluronic acid as an ingestible nutricosmetic ingredient — with promising results. 


    To assess the efficacy of Dermial specifically, Bioiberica conducted this clinical trial, which found that a low dose of 60mg a day could offer ‘powerful regenerative and moisturising properties’ alongside its unique glow-inducing effect, which was achieved six weeks into supplementation. 


    Researchers also observed: 


    • Significant improvements in the appearance of skin wrinkles in the Dermial group at six weeks
    • Those taking Dermial experienced significant improvements in skin smoothness by six weeks
    • Participants given Dermial had reduced skin roughness, while maintaining a more healthy skin pH balance (12 weeks)
    • The Dermial group had brighter and more hydrated skin by the end of the study
    • Those taking Dermial experienced a decrease in skin scaliness


    Meanwhile, participant satisfaction was 69%, with this proportion all stating they were either very satisfied or satisfied with the product. 


     


    Beauty benefits for all ages


    Alongside the measures discussed above, Bioiberica ran a sub-analysis of the study’s results, which suggest that Dermial could also offer different skin-supporting effects depending on a user’s age.


    Interestingly, participants older than 55 experienced significant improvements in biomarkers of skin barrier function — including brightness, hydration, smoothness, deformability, roughness, scaliness and temperature.


    Meanwhile, pH balance was also better maintained in the older group compared with the placebo, suggesting that Dermial can address age-related skin concerns, such as the appearance of wrinkles, dryness, dullness and roughness.


    “We are so excited to share the full details of this ground-breaking debut clinical trial, demonstrating the incredible potential Dermial holds for nutraceutical innovation,” comments Daniel Martínez-Puig, Head of R&D Human and Animal Health at Bioiberica and one of the study’s authors.


    “While overall improvements were less pronounced in volunteers younger than 55 years, they nevertheless experienced benefits in hydration, brightness and smoothness. These results point to the versatility of Dermial as a skin health supplement, able to meet consumers where they are in their skin health journey, regardless of age.”


     


    Reference


    Oral Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study

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  • London Pulse win the Netball Super League Grand Final for the First Time Ever

    London Pulse win the Netball Super League Grand Final for the First Time Ever

    London Pulse won their first ever Netball Super League (NSL) Grand Final this weekend at the O2 Arena, London, live and on demand for the international netball family on NetballPass.

    Pulse, who finished top of the ladder this season and won the pre-season Super Cup, faced defending Champions Loughborough Lightning in front of the biggest NSL Grand Final crowd ever.

    An end-to-end frantic start to the game made it hard to see who was going to come out on top, but once Pulse found their rhythm there was no stopping them.

    England Rose Funmi Fadoju lead the Pulse defensive end as she has all season, making eight deflections, three interceptions and eight gains – a performance she was later awarded Player of the Match for.

    The defensive work of Fadoju, and fellow international and domestic league teammates, Halimat Adoi and Zara Everitt, knocked Lightning and broke down their attacking flow which Pulse were able to capitalise on ensuring they always kept their opposition at arm’s length.

    There were later two Everitt’s on court for a period of time, as Zara’s sister, Darcey Everitt replaced an injured Adio in defence – despite the forced change, Pulse still did not miss a beat.

    Lightning on the other hand had their lowest scoring game of the season, scoring just 45 goals to Pulses 53.

    Pulse became the 7th different team to be crowned NSL Champions, and the first of the new era.                                                 

    One of their players also broke a record of her own, with the introduction of Gracie Smith as a substitute in the match making her the youngest ever player, aged just 16, to feature in a NSL Grand Final.

    You can catch up on the Grand Final on NetballPass, here. *

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  • How Xbox’s Game Pass policies is signalling the doom for the AAA industry | Esports News

    How Xbox’s Game Pass policies is signalling the doom for the AAA industry | Esports News

    Microsoft Xbox Game Pass provides gamers with unprecedented access to hundreds of titles for a very minimal monthly fee. Yet beneath its player-friendly model, as suggested and warned by industry leaders, there’s a gathering storm. This storm as per them, threatens blockbuster game development’s very foundation.Be it unsustainable developer payout or cannibalising sales, Xbox Game Pass, as per reports, is setting a dangerous precedent. The subscription giant and its strategy, as argued, are quietly undermining the AAA ecosystem’s economic pillars, forcing a reckoning that the industry might not survive without being unscathed.

    Game Pass policies have an unsustainable core

    At the heart of this entire crisis is Game Pass’s fundamental economics. As argued by Industry veterans, Microsoft leverages vast resources for subsidizing services. It creates an artificially lower price point. The model, as contended by critics, distorts market value—artificial market conditions created with traditional sales struggling to compete.

    Xbox Dev BLASTS Xbox Game Pass: “This Model DESTROYS Studios”

    Ex-founder of Arkane Studios, Raphael Colantonio, bluntly labelled Game Pass as unsustainable. As per his assertions, it “progressively harmed” the gaming industry for over a decade now, and it survives on corporate subsidies instead of genuine value. He further added that it’s propped by Microsoft’s “infinite money”. It is feared that Microsoft will persist until all alternative business models are crushed. It will leave all developers with a very limited choice.

    Xbox Game Pass for Developers Acts as Double-Edged Sword

    Microsoft’s subscription model promises guaranteed payouts and exposure for developers. But as revealed, Game Pass instead devalues games, conditioning players to expect content for just “free” under their subscription. Probably this was the reason why some major AAA titles, including Monster Hunter Wilds, Kingdom Come: Deliverance II, and Civilisation VII, avoided Xbox Play Anywhere, which is meant to unify the platform.Even Towerborne, the Xbox-published game, chose to launch its early access on Steam and not Xbox. That’s a sign of some internal doubts about the health of the Xbox platform.While smaller studios benefit from all upfront payments, AAA developers face a huge dilemma. If some major titles launch on Game Pass, the standalone sales of the game plummet. Despite Microsoft compensating them, in the long term, this model discourages purchases made at full price. It shrinks revenue streams while funding big-budget games. It even fails to attract Indies or AAA developers.

    Cannibalized sales create a devastating impact

    To understand the above-said better, when a game makes its debut on Game Pass, players do not need to buy it outright. While Microsoft does pay off developers for offsetting losses, it doesn’t replace the traditional sales value that could have been otherwise generated. As said, or rather warned by Michael Douse, Larian Studios’ publishing director, ‘infinite money doesn’t make sense forever.’

    The AAA Gaming Industry Just Got Destroyed From The Inside

    With evidence suggesting that Game Pass cannibalizes traditional sales, particularly on the Xbox platform, there are many who are now raising their voices against it. As per Industry journalist Christopher Dring, games that are launched on Game Pass can easily be expected to lose around 80% of the expected Xbox premium sales.Taking an example of Starfield, its inclusion within Game Pass boosted subscriber members. However, it likely slashed its direct sales. Even Hellblade 2 and Indiana Jones and the Great Circle underperformed in their full-priced Xbox sales. While Microsoft might not have directly blamed it on Game Pass, the correlation here is just undeniable.Even players start to gravitate to “free” access through subscription and bypass outright purchases. Such correlation is not coincidental, but it is structural. When any major release lands on the Xbox Game Pass, buying it becomes redundant. Now, if this starts to become a new norm, studios, especially AAA studios, might struggle to justify massive budgets. This will lead to a few AAA risks and a high reliance on Microsoft’s funding.

    Xbox Game Pass offers a false lifeline to smaller studios

    Proponents quite often highlight that Game Pass does act as a boon to smaller developers and all the risky new IPs. Douse acknowledges this potential. As noted by him, it could derisk those smaller teams’ launch, which face uncertain markets, but what exactly would happen when all the money runs out?

    Is Xbox Game Pass BAD for Developers?

    The current model is reliant on continuous and massive investments made by Microsoft to secure content. However, if funding shifts or slows down, the safety net for smaller studios would vanish overnight. It would leave them exposed, without any security for the creative risks.

    Game Pass: Destroying Gaming? Indie Devs Reveal Shocking Truth!

    But wait, there’s more beyond money running out. Game Pass, which initially was praised to help Indie games reach a wide audience, isn’t the same anymore. With growing services, smaller titles are at higher risk of getting buried within an oversaturated catalogue. Unlike Steam, where the games remain purchasable quite indefinitely, Game Pass keeps rotating titles in and out. It leaves developers scrambling for needed visibility.Even some successful indies are now facing a catch-22—Microsoft’s short-term payouts vs. Long-term sustainability. If the players do not buy outside the subscriptions, Indies would lose leverage over pricing and discoverability at the same time.

    Player Advantage vs Developer Disadvantage

    Why Xbox Game Pass Ultimate is Still the Best Deal

    For the players, Game Pass is quite an undeniably phenomenal deal. It gives instant access to a vast library that includes all major releases. With day-one access to the content, there’s an incredible value for players. It democratizes gaming. It makes AAA experiences affordable for those who might not otherwise participate in them. But what about AAA studios? They get forced to profit outside the subscriptions, and for it, they would either cut budgets or shift to live-service models, to sustain revenue.

    Is XBOX Game Pass Bad for Developers?

    For developers, especially those who are behind those large-budgeted AAA games, the entire picture is more grim. Xbox Game Pass subscription model devalues individual titles. Players who are accustomed to the lower monthly fee just become resistant to paying $70 for a purchase. This creates a shift in revenue stream from direct sales to those opaque subscription payouts as per engagement metrics. It creates huge financial uncertainty that is lethal for the AAA industry, especially for studios that invest $200M+ in projects.It is due to this that Colantonio has suggested Game Pass to keep its focus on back-catalogue titles and not day-one releases. It will help preserve sales for the newer games while still continuing to offer value. But will Game Pass do so? Only time can tell about it.

    Escalating situation seeks balance before the bubble bursts

    The industry is not calling for the demise of Game Pass, but it wishes for a critical reassessment. Colantonio and many others have already suggested a sustainable path for it—Game Pass must primarily function as the back-catalogue service and not the day-one AAA release platform. It will help preserve the value proposition for the players. It will also protect the economic model, which is required to fund ambitious and new projects.The current trajectory that’s been fueled by deep pockets of Microsoft risks creating a market where only subscription giants could survive. Without bringing in an urgent policy adjustment or a fundamental shift within the Game Pass model, the ability to fund next-generation, groundbreaking AAA experiences faces existential peril. So, in short, the time for a balance is right now.

    What will the AAA industry be without this balance?

    WILL XBOX GAME PASS LAST? Pros & Cons of Microsoft’s Game Pass

    The gaming industry today is at a crossroads. If the Game Pass continues to dominate, the world will see fewer big-budget single-player games, which will also be riskier without a direct sales line. There will also be more live-service and microtransactions models for offsetting lost revenue. Additionally, with increased consolidations of studios under Microsoft, competition will be reduced.The solution is therefore simple. There’s a need for a balanced approach. Subscriptions must complement, instead of replacing, the traditional sales. Otherwise, Xbox Game Pass might accelerate the decline of AAA games, on which it relies.


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