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  • Good News for Tofacitinib in Recent Study of Acute Severe UC

    Good News for Tofacitinib in Recent Study of Acute Severe UC

    A head-to-head comparison of the JAK inhibitor drug tofacitinib and chimeric monoclonal antibody infliximab in the treatment of acute severe ulcerative colitis (ASUC) shows that, contrary to concerns, tofacitinib is not associated with worse postoperative complications and in fact may reduce the risk of the need for colectomy.

    “Tofacitinib has shown efficacy in managing ASUC, but concerns about postoperative complications have limited its adoption,” reported the authors in research published in Clinical Gastroenterology and Hepatology.

    “This study shows that tofacitinib is safe and doesn’t impair wound healing or lead to more infections if the patient needs an urgent colectomy, which is unfortunately common in this population,” senior author Jeffrey A. Berinstein, MD, of the Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, told Medscape Medical News. 

    Recent treatment advances for UC have provided significant benefits in reducing the severity of symptoms; however, about a quarter of patients go on to experience flares, with fecal urgency, rectal bleeding, and severe abdominal pain of ASUC potentially requiring hospitalization.

    The standard of care for those patients is rapid induction with intravenous (IV) corticosteroids; however, up to 30% of patients don’t respond to those interventions, and even with subsequent treatment of cyclosporine and infliximab helping to reduce the risk for an urgent colectomy, patients often don’t respond, and ultimately, up to a third of patients with ASUC end up having to receive a colectomy.

    While JAK inhibitor therapies, including tofacitinib and upadacitinib, have recently emerged as potentially important treatment options in such cases, showing reductions in the risk for colectomy, concerns about the drugs’ downstream biologic effects have given many clinicians reservations about their use.

    “Anecdotally, gastroenterologists and surgeons have expressed concern about JAK inhibitors leading to poor wound healing, as well as increasing both intraoperative and postoperative complications, despite limited data to support these claims,” the authors wrote.

    To better understand those possible risks, first author Charlotte Larson, MD, of the Department of Internal Medicine, Michigan Medicine, and colleagues conducted a multicenter, retrospective, case-control study of 109 patients hospitalized with ASUC at two centers in the US and 14 in France.

    Of the patients, 41 were treated with tofacitinib and 68 with infliximab prior to colectomy. 

    Among patients treated with tofacitinib, five (12.2%) received infliximab and four (9.8%) received cyclosporine rescue immediately prior to receiving tofacitinib during the index admission. In the infliximab group, one (1.5%) received rescue cyclosporine.

    In a univariate analysis, the tofacitinib-treated patients showed significantly lower overall rates of postoperative complications than infliximab-treated patients (31.7% vs 64.7%; odds ratio [OR], 0.33; P = .006).

    The tofacitinib-treated group also had lower rates of serious postoperative complications (12% vs 28.9; OR, 0.20; P = .016).

    After adjusting for multivariate factors including age, inflammatory burden, nutrition status, 90-day cumulative corticosteroid exposure and open surgery, there was a trend favoring tofacitinib but no statistically significant difference between the two treatments in terms of serious postoperative complications (P = .061). 

    However, a significantly lower rate of overall postoperative complications with tofacitinib was observed after the adjustment (odds ratio, 0.38; P = .023).

    Importantly, a subanalysis showed that the 63.4% of tofacitinib-treated patients receiving the standard FDA-approved induction dose of 10 mg twice daily did indeed have significantly lower rates than infliximab-treated patients in terms of serious postoperative complications (OR, .10; P = .031), as well as overall postoperative complications (OR, 0.23; P = .003), whereas neither of the outcomes were significantly improved among the 36.6% of patients who received the higher-intensity thrice-daily tofacitinib dose (P = .3 and P = .4, respectively).

    Further complicating the matter, in a previous case-control study that the research team conducted, it was the off-label, 10 mg thrice-daily dose of tofacitinib that performed favorably and was associated with a significantly lower risk for colectomy than the twice-daily dose (hazard ratio 0.28; P = .018); the twice-daily dose was not protective.

    Berinstein added that a hypothesis for the benefits overall, with either dose, is that tofacitinib’s anti-inflammatory properties are key.

    “We believe that lowering inflammation as much as possible, with the colon less inflamed, could be providing the benefit in lowering complications rate in surgery,” he explained.

    Regarding the dosing, “it’s a careful trade-off,” Berinstein added. “Obviously, we want to avoid the need for a colectomy in the first place, as it is a life-changing surgery, but we don’t want to increase the risk of infections.” 

    In other findings, the tofacitinib group had no increased risk for postoperative venous thrombotic embolisms (VTEs), which is important as tofacitinib exposure has previously been associated with an increased risk for VTEs independent of other prothrombotic factors common to patients with ASUC, including decreased ambulation, active inflammation, corticosteroid use, and major colorectal surgery.

    “This observed absence of an increased VTE risk may alleviate some of the hypothetical postoperative safety concern attributed to JAK inhibitor therapy in this high-risk population,” the authors wrote.

    Overall, the results underscore that “providers should feel comfortable using this medication if they need it and if they think it’s most likely to help their patients avoid colectomy,” Berinstein said.

    “They should not give pause over concerns of postoperative complications because we didn’t show that,” he said.

    Commenting on the study, Joseph D. Feuerstein, MD, of the Department of Medicine and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, noted that, in general, in patients with ASUC who fail on IV steroids, “the main treatments are infliximab, cyclosporine, or a JAK inhibitor like tofacitinib or upadacitinib, [and] knowing that if someone needs surgery, the complication rates are similar and that pre-operative use is okay is reassuring.”

    Regarding the protective effect observed with some circumstances, “I don’t put too much weight into that,” he noted. “[One] could speculate that it is somehow related to faster half-life of the drug, and it might not sit around as long,” he said.

    Feuerstein added that “the study design being retrospective is a limitation, but this is the best data we have to date.”

    Berinstein and Feuerstein had no disclosures to report.

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  • Apple’s New Deal Makes Vision Pro Ultra Realistic & Human

    Apple’s New Deal Makes Vision Pro Ultra Realistic & Human

    Apple just made a game-changing move in the XR arena by acquiring TrueMeeting, a cutting-edge Israeli business that creates ultra-realistic 3D avatars through real-time facial scanning. The agreement, signed earlier this year, is currently driving a significant improvement in Vision Pro’s Persona function, giving Apple’s headset a significant advantage in lifelike virtual presence.

    This acquisition, revealed by EU regulatory papers, brings TrueMeeting’s whole staff inside Apple’s worldwide AR and AI divisions in Israel and Silicon Valley. The startup’s groundbreaking technology is already being tested in visionOS 26, where Apple is covertly developing the most humanlike avatars ever seen in XR.

    TrueMeeting Tech Upgrades Vision Pro’s Digital Personas

    TrueMeeting’s real-time, photorealistic avatars from iPhone facial scans are its highlight. This new software emphasizes natural movement, facial expressiveness, and accurate hair depiction, unlike Apple’s first-generation Personas, who were criticized for their artificial expressions.

    Early beta builds of visionOS 26 show significant improvements. Testers say the new Personas look “eerily real,” reflecting eye movement, blinks, and micro-expressions—bringing Apple closer to real presence in virtual meetings.

    What Is TrueMeeting and Why Apple Bought It

    TrueMeeting (formerly CommonGround AI) was founded in 2019 and raised around $45 million from Matrix Partners and Grove Ventures. Its focus has always been one thing: realistic human avatars for virtual environments.

    Apple’s acquisition secures exclusive access to this groundbreaking pipeline. It also sets the stage for a Vision Pro that feels less like a headset, and more like a portal to real human interaction.

    Strategic Timing and Market Advantage

    This move comes alongside Apple’s quieter acquisition of WhyLabs, an AI safety firm. Together, the two buys show Apple’s two-track strategy: build immersive virtual experiences while keeping AI hallucination-free.

    With Meta, Google, and Samsung all pushing their XR visions, Apple is now leading the race. Although they have made it very clear. They do not want to compromise on privacy, performance, or emotion. Whether that actually happens is a news story for another time.

    Why This Matters for the Future of XR

    Apple’s Vision Pro was already praised for its stunning visuals and interface. But avatars lagged behind, until now. TrueMeeting’s tech makes it possible to interact in VR and spatial video calls as if you were physically present.

    This could transform the way we do remote work, socialize, teach, or even perform on-stage, as well as use it to improve eye sight. With visionOS 26 on the way, the next version of “you” is going to look a lot more like… you.

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  • Police can’t delay or refuse registration of any incident’s FIR: SC

    Police can’t delay or refuse registration of any incident’s FIR: SC

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    ISLAMABAD, Jul 11 (APP):The Supreme Court of Pakistan on Friday accepted the acquittal appeal of an accused Sita Ram in murder case declaring that the police cannot refuse or delay the registration of first information report (FIR) of any incident as it could lead to injustice or loss of evidence.

    Justice Athar Minallah wrote a 30-page verdict, in which the court accepted the appeal of accused Sita Ram in murder case. The court said in the verdict that the prosecution had failed to present evidence against the accused. It should be noted that Sita Ram was accused of killing Chandra Kumar in 2018.

    The court said in the verdict that despite the timely information of the plaintiff, the case was registered with a delay of 2 days. The SHO admitted that the information was registered in the newspaper, but not an FIR.

    The order said that registration of a case is mandatory in a cognizable offence. Delay in registration of cases has been seen in most cases in Sindh. Registration and investigation of cases are executive processes and it is an important and fundamental part of the criminal system.

    The Supreme Court said in its verdict that it is the legal responsibility of the duty officer to register a case as soon as possible after receiving information. A police officer cannot refuse or delay the registration of a case. Delay has an impact on the accused and the plaintiff, and it could lead to the loss of evidence and the involvement of innocent people.

    The verdict said that the police force and police stations are for the service of the public. A report was also submitted by the IG Sindh and the Prosecutor General in the case. The reasons given in the order included cultural practices, attempts to reconcile the complainants, and religious beliefs that were not in accordance with the law.

    According to the court decision, the police’s failure to register an FIR is a constitutional violation and is a denial of justice. The trend of delay in registering an FIR in Sindh is worrying. Delay in FIR is an injustice to the weak, poor and backward classes. The police are serving the powerful class, not the people.

    The decision further said that the perception of a police state is dangerous, we need to move towards a constitutional state. Every police officer is strictly bound by the constitution. The Supreme Court, in its decision, directed the IGs of all provinces to ensure implementation of the law and said that the Prosecutor Generals should formulate SOPs and restore public trust.

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  • President, PM urge responsible parenthood on World Population Day – Pakistan

    President, PM urge responsible parenthood on World Population Day – Pakistan

    President Asif Ali Zardari and Prime Minister Shehbaz Sharif urged awareness on responsible parenthood and family planning to address population growth on the World Population Day on Friday, state-run Radio Pakistan reported.

    Established by the then-Governing Council of the United Nations Development Programme in 1989 and observed on July 11 every year, World Population Day seeks to focus attention on the urgency and importance of population issues, including their relations to the environment and development.

    The president, in his message to the nation, said that the challenge of population growth continued to hinder the country’s national development process which necessitated a comprehensive, and inclusive approach, state-run Associated Press of Pakistan reported.

    “When community leaders, elders, and civil society organisations promote the benefits of responsible parenthood and support access to family planning, societal attitudes begin to change. The media also has a central role to play in raising awareness and promoting healthy practices, and can significantly influence public behaviour,” he said.

    The president said that this year’s theme — which was to empower young people to create the families they want in a fair and hopeful world — captured the essence of Pakistan’s demographic reality.

    “With our population exceeding 242 million, the urgency to adopt forward-looking, evidence-based population policies has never been greater than it is at present. We have a huge youth bulge — our greatest strength, if nurtured through access to education, healthcare, opportunities, and agency.”

    Highlighting the pressure of population growth on the country’s national resources, health and education infrastructure, and public services, he said that the rising unemployment, environmental degradation, deforestation, and overstretched health and education systems were symptoms of the imbalance between population size and available resources.

    President Zardari called to expand access to quality family planning services, particularly in rural areas, with a focus on women’s education and employment who should be given equal opportunities, as their empowerment directly influences family choices.

    He also called for the government to enhance its focus on a comprehensive population agenda, guided by the principle of tawazun (balance) — achieving harmony between population growth and resource availability.

    “This approach is supported by stakeholders across sectors, including religious leaders, policymakers, and development partners. It reflects our shared commitment to securing a healthier, more equitable, and resource-efficient future.”

    He also stressed the need for adopting international best practices including integrating family planning into primary healthcare systems, promoting reproductive health through community-based outreach, deploying trained female health workers at the grassroots level, and using mass media to promote public education and behavioural change.

    “Such strategies can help stabilise population growth,” he added.

    Pakistan’s youth can become a dynamic force: PM

    In his message, PM Shehbaz said that his government was fully committed to a comprehensive, rights-based population agenda with a focus on equitable access to healthcare, informed family planning, and strengthening systems allowing individuals to make choices about their future with dignity and autonomy, according to APP.

    “These efforts are fully aligned with Pakistan’s commitments under the Sustainable Development Goals and Family Planning 2030 targets. The stability of population growth requires a coherent, multi-sectoral approach,” he said.

    “With a population of 242 million, approximately 65 per cent of whom are under the age of 30, Pakistan stands at a critical juncture in its history. This huge youth population represents both an extraordinary opportunity and a significant challenge,” he remarked.

    PM Shehbaz said that Pakistan’s young population could become a dynamic force driving innovation, productivity, and national development if attention was given to their good upbringing and empowerment.

    “However, managing such a large and growing population also places immense pressure on public resources and governance systems,” he added.

    He urged all stakeholders, including federal and provincial governments, development partners, civil society, the private sector, religious leaders, and local communities, to fulfil their shared responsibility and commitment to address these population challenges and build a healthier, more prosperous future for Pakistan.

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  • Paramount+ Celebrates New Release With ‘Dexter: The Experience’

    Paramount+ Celebrates New Release With ‘Dexter: The Experience’

    Paramount+ is offering Londoners a chance to live like a serial killer in celebration of the release of Dexter: Resurrection.

    From Jul. 10-13, fans will be able to get their hands bloody at Dexter: The Experience, an immersive journey in London’s East End where guests work as Dexter’s dark passenger for over 40 minutes to solve puzzles and evade capture.

    Narrated by Dexter star Michael C. Hall, actors guide ticket-holders through the experience as fans of the franchise get to join the forensics department at Miami Metro Police Department, piece together body parts left by the Ice Truck Killer and get some chilling photo ops under Dexter’s signature plastic wrap or in the Trinity Killer’s bathtub of blood.

    At the end of the immersive experience is the opportunity to order show-themed cocktails at the Cuban Bar and browse a range of merchandise thoughtfully curated by the Paramount+ team. Tickets have been released to waitlist sign-ups.

    Dexter: Resurrection premieres on Paramount+ on Jul. 11, and previous seasons of Dexter and Dexter: New Blood are also available on the platform. Prequel series Dexter: Original Sin with Paddy Gibson in the titular role is also on the streaming service.

    ‘DEXTER: THE EXPERIENCE’.

    Paramount+

    The Hollywood Reporter‘s recently-released review of Dexter: Resurrection describes the show as “an amusing but unnecessary gamble.”

    TV critic Daniel Feinberg wrote: “All of the grounding and clarity of purpose that carried Dexter: New Blood is gone, but if the version of Dexter that you enjoy was already borderline cartoonish — and the show is, and always has been, a dark comedy at heart — there’s entertainment to be found here.”

    ‘DEXTER: THE EXPERIENCE’ takes place in Shoreditch, London.

    Paramount+

    ‘DEXTER: THE EXPERIENCE’ gets fans of the show working at the Miami Metro Police Department.

    Paramount+

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  • Jamie Dimon has a blunt message for Europe: ‘You’re losing’

    Jamie Dimon has a blunt message for Europe: ‘You’re losing’

    Key Points

    • Jamie Dimon told an event in Ireland on Thursday that Europe was “losing” on competitiveness and lacked the kind of global, successful corporations common in the U.S.
    • The JPMorgan Chase boss also told an event in Ireland that there was “complacency in the markets” around U.S. tariffs and rates.
    • Dimon said he saw a 40-50% chance that the Federal Reserve would need to raise interest rates to tackle inflation, against market pricing of around a 20% chance.

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  • US star Tobin Heath announces her retirement from professional football

    US star Tobin Heath announces her retirement from professional football

    Tobin Heath, one of the most influencial women’s players in U.S. history, has announced she is retiring from professional football, disappointing many of her fans who had hoped to see her take to the pitch once again.

    The 37-year-old four-time Olympian revealed the decison on her RE-CAP Show podcast on Thursday (10 July).

    “I think I had a few more mountains I wanted to climb with football, even though I’m really grateful for the career that I had,” she on the podcast.

    “I get the question all the time: ‘So, are you coming back?’ — and kind of like, well, the writing’s on the wall.”

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  • LOGHAN LEWIS MAKES LONG AWAITED RETURN IN ROUND 18 SQUAD

    LOGHAN LEWIS MAKES LONG AWAITED RETURN IN ROUND 18 SQUAD

    Aussie prop, Loghan Lewis has been selected in the 21-man squad for the first time in 2025, ahead of Sunday’s clash with Castleford Tigers.

    It’s a double-header at the Salford Community Stadium, with our women’s team also taking to the main field at 12pm against Bradford Bulls.

    But the main event promises to be a cracker, with both sides looking to find a much-needed win. The Tigers, after a string of defeats, have parted company with Danny McGuire and placed Chris Chester in temporary charge.

    There are a few familiar faces in the Cas set-up, including prop, Brad Singleton and versatile back, Chris Atkin.

    In the red corner, however, the return of Lewis is a huge boost to the team after making a bruising impact following his move from the Canberra Raiders in 2024.

    There’s also a first outing for loan signing, Oliver Russell and a spot for development player, Declan Murphy, who impressed in his Reserves’ outing last Friday.

    Salford Red Devils vs Castleford Tigers (SL18) squad list:

    1. Ryan Brierley (C)
    2. Ethan Ryan
    6. Jayden Nikorima
    10. Chris Hill
    13. Joe Shorrocks
    16. Loghan Lewis
    17. Esan Marsters
    18. Jack Ormondroyd
    19. Justin Sangare
    22. Matty Foster
    23. Chris Hankinson
    24. Harvey Wilson
    27. Kai Morgan
    28. Nathan Connell
    30. Tiaki Chan
    44. Oliver Russell
    50. Toby Warren
    52. Dan Russell
    53. Tom Whitehead
    57. Declan Murphy


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  • Decision to drop zonal pricing for GB electricity generation welcomed

    Decision to drop zonal pricing for GB electricity generation welcomed

    The conclusion means that the government does not intend to introduce zonal pricing and instead will implement an ambitious approach to reformed national pricing – a cohesive package of reforms to improve the effectiveness of the national pricing model. This package sets out to deliver a more strategic and co-ordinated approach to the energy system, provide strong signals for efficient siting of new assets, and improve overall operational efficiency, whilst also increasing stability and certainty for investors.

    Ronan Lambe, energy projects expert at Pinsent Masons, said: “Stakeholders warned that the introduction of zonal pricing would cause significant investment risk, creating uncertainty and raised costs. We have already seen the potential impact of these proposed changes to create such uncertainty across a variety of deals, particularly where electricity prices need to be secured across an extended period of time.”

    The government hopes that reformed national pricing will provide certainty for investors, aligning network and connection charges with strategic planning to support long term investment. The strategy also aims to provide fairness for consumers. Consumers will continue to benefit from uniform national pricing, with locational costs absorbed through broader market mechanisms like contracts for difference (CfDs) and the capacity market. It is also hoped that reformatted national pricing will provide lower costs, simplifying the investment processes and better siting reduce costs, helping to lower consumer bills

    Gabby Greenslade, energy projects lawyer at Pinsent Masons, said: “The reformed national pricing approach emphasises stability and resilience – both crucial to navigating the energy transition by offering investors and consumers the predictability required to plan confidently.”

    At the core of the reforms will be the strategic spatial energy plan (SSEP), which will guide co-ordinated planning and proactive network investment. It will map optimal locations and types of energy infrastructure to support the UK’s clean energy transition, aiming to reduce delays and costs in connecting new projects to the grid. The plan will work to coordinate important levers such as planning reform, seabed leasing, network development, and connection and charging reforms.

    The first version of the SSEP, covering electricity and hydrogen generation and storage, is expected in 2026 and “will assess infrastructure needs regionally, providing clarity to industry while allowing market competition to determine the best projects to pursue”,  said Lambe.

    Further upcoming actions include the publication of a reformed national pricing delivery plan, outlining the design and implementation roadmap – expected later this year. The government is expected to release the final review of electricity market arrangements (REMA) analysis, including a full cost-benefit analysis of wholesale market reform options later this year.

    By the end of 2026, a collaboration between National Energy System Operator (NESO) and the government is expected in order to deliver the SSEP. The government will also work with Ofgem to advance reforms to transmission network use of system (TNUoS) and connection charges. Additionally, a consultation on balancing reform and completing NESO’s constraints collaboration project is also expected by the end of the year.

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  • Add to playlist: Sarah Meth’s resplendent, intimate songwriting and the week’s best new tracks | Music

    Add to playlist: Sarah Meth’s resplendent, intimate songwriting and the week’s best new tracks | Music

    From North London
    Recommended if you like Helena Deland, Billie Eilish, Okay Kaya
    Up next
    Headlining Bermondsey Social Club, 30 July; playing Green Man festival, Brecon Beacons, August

    London-based singer-songwriter Sarah Meth makes eerie, skeletal dream-pop cut through with a self-deprecating, very online sense of humour. A scan of her artist page on any streaming service offers a gratifying biography of an artist slowly but surely chipping away at her style in search of a distinct point of view: the lounge jazz stylings of 2020’s Dead End World give way to piquant, post-King Krule bedroom pop on 2022’s Leak Your Own Blues and Billie Eilish-ish pathos on 2023’s Steps EP.

    What could feel like a dog’s dinner of genres is held together by Meth’s warm, laconic voice and knack for resplendent but pathologically small-scale production. Winnies, a song from last year’s NY ILY single, is built atop a delirious, translucent organ line. Unlike many of her songs, which deal in winking self-subjugation, Winnies is about a blooming sense of self-determination, and Meth smartly plays it as something that could disappear at any moment.

    At a recent show at London’s Theatreship, a cabaret theatre on a boat in Canary Wharf, Meth previewed new songs that alternated between amenable folk music in the style of Julia Jacklin and Angel Olsen, and shimmery, skew whiff pop songs that she sang over a prerecorded track. The modes proved surprisingly complementary – indie music ego and id, maybe, or a real-time battle between extroversion and introversion. The new songs were indelible and exciting: memorable odes to growing up, and falling in and out of love, that stand out in a crowded field of indie-pop newcomers. Shaad D’Souza

    This week’s best new tracks

    Debby Friday. Photograph: Lucy Mahoney/JuliArtFlash

    Debby Friday – Bet on Me
    “Scared of what just might happen / If I go ahead and bet on me,” the Canadian pop star exhales over anxious breakbeats, building to a cheerleader chant riotous with self-belief. LS

    Galya Bisengalieva – Alash-kala (The Bug Reflection)
    From a new EP also featuring an ambient reinterpretation by KMRU, this remix of Alash-kala sees Kevin “The Bug” Martin blow the Kazakh-British composer’s lonely, glacial crackle up to an end-of-days cataclysm. LS

    Danny L Harle & PinkPantheress – Starlight
    Harle is a hard dance revivalist and a pop producer for Caroline Polachek and Dua Lipa, and both impulses cohere on this soft-donk stomper with Grimes-ish vocals from PinkPantheress. BBT

    Agriculture – Bodhidharma
    Anyone lamenting the loss of Black Sabbath this week should turn to this crushing post-metal anthem, with a splendid sky-scorching riff as well as eerie sound design and quiet-loud thrills. BBT

    Geese – Taxes
    After frontman Cameron Winter became an indie darling thanks to his classic solo debut Heavy Metal, Geese return with a winner: a rumpled slacker tune that straightens up and sticks out its chest for a joyful chorus. BBT

    SJ – Ozil
    With cool, softly swinging jazz obliterated by the arrival of a hard-headed drill beat, the Tottenham MC sprinkles references to his footballing past with the nimbleness of a boy-wonder midfielder. [Not on Spotify] BBT

    Fever Ray – Now’s the Only Time I Know (Therapy Session)
    Karin Dreijer is releasing an album of studio mixes of live versions of old songs: this spooked song about domesticity from their 2009 debut becomes a savage, ravey exorcism. LS

    Subscribe to the Guardian’s rolling Add to Playlist selections on Spotify.

    Add to playlist – Spotify Spotify

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