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  • Hoops powerhouse favours chemistry over all-stars at Rhine-Ruhr 2025

    Hoops powerhouse favours chemistry over all-stars at Rhine-Ruhr 2025

    Unlike most basketball teams set to compete at the Rhine-Ruhr 2025 FISU World University Games, the United States’ squads feature student-athletes from the same universities. This year in Germany, the Baylor University men and Texas Tech women were selected to represent their delegation.

    Men’s head coach Scott Drew sees distinct advantages in UniUSA’s approach of selecting a side from a single school, rather than the traditional approach of choosing a collection of all-stars from around the country.

    “When you put all-star teams together, you don’t have the chemistry and the familiarity plus you don’t have (the) same offense and defense, and you have to put everything in in a real quick manner,” Drew said during a USA Basketball media conference on 16 July at the FISU Games Main Press Centre in Essen. “Bringing university teams over that have had a chance to practice together gives you a better team.”

    Shooting guard Cameron Carr added that representing both his country and his university is a rare opportunity. “Since our team was chosen to do it, it’s another opportunity for us to grow as a team and it’s a great experience.”

    The next generation

    Carr is one of two players on the USA’s men’s team who have elite-level basketball in their lineage.

    His father Chris played in the NBA from 1995 to 2001 and finished runner-up to Kobe Bryant in the league’s 1997 Slam Dunk Contest.

    Meanwhile, incoming freshman Andre “Iggy” Iguodala II, also a guard, is the son of Andre Iguodala, who played in the world’s top circuit for 19 years and won NBA Finals MVP with the Golden State Warriors in 2015.

    “I would say he had a good foundation for me,” Carr said about his father. “Laying out the road for me and showing me how to go about things because he’s been where I want to go.”

    However, he added he has to be his own player and not try and be exactly like his dad. “I got to write my own story at the end of the day.”

    Friendly rivalry

    While most of Baylor’s team will represent the USA in the men’s tournament, one member of the squad, Michael Rataj, will be suiting up for the host country of Germany at these FISU Games.

    “I get to compete against him every day at practice,” Carr said. “Of course, that’s fun, but when you step between the lines and the actual intense game, there’s way more energy, there’s a lot more going on.”

    With a big smile on his face, guard JJ White said that Rataj is “so good it makes me mad,” and that he told his Baylor teammate to “play your worst out there and come back (to Baylor) and play better.”

    “I know he’ll be good,” White said. “He’s really good, so it’ll be fun going against him and when he comes back, he’ll be home.”

    USA Women’s Basketball Press Conference Rhine-Ruhr 2025 FISU Games | 16.07.2025 | Essen | Messe Essen | Basketball | © Michael Chisholm / Rhine-Ruhr 2025

    From manager to minutes

    Meanwhile, due to ineligible international players and early-season roster issues, Team USA’s women’s side is giving an unlikely candidate a chance to shine on the international stage.

    “When you start in April, and you end your season, you immediately go into recruiting mode,” head coach Krista Gerlich said. “We had to replace a lot of our roster… and so really, to be honest, we didn’t have our roster complete until the beginning of May, and we were having to put numbers in for this tournament very soon after that.”

    Laci White, a Texas Tech team manager, stopped playing organised basketball in high school due to a knee injury. When the time came to select her roster for the FISU Games, Gerlich decided to give White the final spot.

    “She was already there with us, and she could immediately start practicing, so that’s why we chose to move her up,” Gerlich said. “I think she had an instant impact with our kids just because they love her so much, because how hard she works for our programme.”

    The USA women face a tough challenge in their FISU Games opener as they are set to battle host Germany on Friday, 18 July. In men’s action, the United States debut against India on Saturday, 19 July.

    The Rhine-Ruhr 2025 FISU World University Games take place from 16-27 July. Watch all the competitions live on fisu.tv. Click on the link to find the full schedule. 

    Written by Fisher Madsen, FISU Young Reporter, USA

    The Young Reporters Programme exemplifies FISU’s commitment to more than sports competitions. At every FISU World University Games, a group of talented aspiring sports journalists are chosen to cover the competition. 

    We warmly thank FISU Official Partner Qiaodan Ltd. which provides remarkable uniforms to FISU Family and International Technical Officials since 2015. Qiaodan is a valuable partner for FISU as it continued to provide its support during the postponement of events due to the global pandemic, and recently extended the relationship with FISU up to and including 2025.

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  • CRISPR-mediated DNA methylation editing regulates inflammation and tumor growth

    CRISPR-mediated DNA methylation editing regulates inflammation and tumor growth

    Genes, fragments of DNA located on our chromosomes, control much of what happens in cells. Each cell activates only the genes it needs, silencing the rest through molecular “switches” present on each gene. However, these switches can sometimes be erroneously activated, leading the cell to behave abnormally and potentially resulting in diseases such as cancer or autoimmune disorders.

    The activity of these “switches” is regulated by their methylation status, chemical marks that can be added to or removed from DNA. Thanks to new tools based on CRISPR-Cas9 technology, the team led by Dr José Luis Sardina, group leader at the Josep Carreras Institute, has succeeded in controlling the “switch” of the IL1RN gene in cells derived from human leukemia, turning it on or off by adding or removing these chemical marks.

    The results of the study, led by Dr Gemma Valcárcel and conducted in collaboration with Dr. Esteban Ballestar’s team, have just been published in the prestigious journal Science Advances. The research demonstrates how precise control of IL1RN gene activity affects the production of inflammatory cells that respond abnormally to external stimuli. This altered response causes the cells to produce modified inflammatory cytokines, showing a distinct capacity to modulate tumor growth in laboratory models.

    This proof of concept demonstrates that it is possible to regulate the activity of key immune system genes such as IL1RN through DNA methylation, thereby modulating functions like inflammation or tumor progression. Although researchers already suspected that such chemical modifications could influence immune system behavior, this study provides the first experimental evidence confirming that connection and revealing its functional consequences.

    With this knowledge and the technological capability to activate or deactivate individual genes with precision, the door is opened to the development of new strategies aimed at intervening in the most fundamental biological processes of immune cells and, potentially, new therapies for certain subtypes of leukemia and other diseases with an inflammatory component.

    This work was funded by the Government of Spain, the Government of Catalonia, the Carlos III Health Institute, and Worldwide Cancer Research.

    Source:

    Josep Carreras Leukaemia Research Institute

    Journal reference:

    Valcárcel, G., et al. (2025). Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing. Science Advances. doi.org/10.1126/sciadv.adt1644.

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  • Deep Pulses Under Africa: Insight Into Volcanic Activity

    Deep Pulses Under Africa: Insight Into Volcanic Activity

    Earth’s continents may look fixed on a globe, but they’ve been drifting, splitting and reforming over billions of years – and they still are. Our new study reveals fresh evidence of rhythmic pulses of molten rock rising beneath east Africa, reshaping our understanding of how continents break apart.

    Authors

    • Emma Watts

      Postdoctoral Researcher in Geography, Swansea University

    • Derek Keir

      Associate Professor of Earth Science , University of Southampton

    • Thomas Gernon

      Professor in Earth & Climate Science, University of Southampton

    Our findings could help scientists understand more about volcanic activity and earthquakes.

    There are around 1,300 active volcanoes on the Earth’s surface . Active volcanoes are those thought to have had an eruption over the last 12,000 years or so. Of these volcanoes, over 90 lie on the East African Rift Valley – the seam along which Africa is splitting apart. This weak seam of crust may even allow a new ocean to form over the next few million years.

    Although ocean formation is happening around the world, and has been for several billion years, there are few places on Earth where you can study different stages of continental breakup at the same time. This is because they normally become submerged under water as the Earth’s crust thins, and seawater eventually inundates the rift valley.

    Get your news from actual experts, straight to your inbox. Sign up to our daily newsletter to receive all The Conversation UK’s latest coverage of news and research, from politics and business to the arts and sciences.

    The Rift Valley is different. There is, at its northern end (in Ethiopia) a place called Afar, which sits at the meeting point of three rifts . These are called the Red Sea Rift, the Gulf of Aden Rift, and the Main Ethiopian Rift (see the map below).

    The Red Sea Rift has been spreading for the last 23 million years , and the Main Ethiopian Rift for the last 11 million years . There are active volcanoes across all three of these rifts. In Afar, all three rifts are at least partly exposed, with the Red Sea Rift and Main Ethiopian Rift having the most exposure.

    Volcanic rocks that erupt when Earth’s tectonic plates spread apart provide a window into the inner Earth that wouldn’t otherwise be accessible. Each lava flow and volcano has its own story that is recorded in the rock and we can learn about that through geochemistry – the concentrations of the elements that make up the rock – and mineralogy – the minerals within the rock.

    Analysing these things can tell us about the depth at which the melting rock formed and roughly where in the Earth’s mantle it formed. In our new study, we analysed over 130 new lava samples, obtained from the Afar rock repository at the University of Pisa and our own fieldwork.

    We used these samples to investigate the characteristics of the mantle beneath this rifting, when tectonic plates are moving apart from each other. These samples are from Holocene eruptions (rocks younger than 11.7 thousand years old) from across Afar and the East African Rift.

    Since the 1970s, scientists have believed that there is a mantle plume beneath the Afar region. Mantle plumes are a portion of abnormally hot mantle (around 1,450°C) or unusual composition of the mantle (or both) below the Earth’s surface. Scientists think it pushed some of the mantle to the Earth’s surface. Our study not only confirms the presence of a mantle plume in this region, but also gives scientists details about its characteristics.

    We discovered that the mantle plume beneath the region rises beneath the tectonic plates in pulses, and the pulses have slightly different chemical compositions.

    There are mantle plumes around the world. They can be identified in the geological record as far back as several billion years . Each of the plumes has different characteristics – with their own unique chemical composition and shape.

    One mantle plume still active today is the one lying below the Hawaiian islands. These islands are part of the Hawaiian Emperor chain, formed over the last 80 million years or so , and are still forming today. The islands originate from the Pacific tectonic plate slowly moving across the top of a mantle plume, making lava bubble up, erupt and eventually solidify as rock.

    This plume melts the Earth’s mantle and forms magma, which over long periods results in the formation of an island chain or breaks up continents. It can also form volcanoes along a rift in the Earth’s crust, as we see in east Africa. The Hawaiian plume signature comes from two chemical compositions rising up through the mantle together like two vertical strands.

    While scientists have long thought there probably is a plume underneath Afar, what it looks like is debated .

    In our study, we created several scenarios of what the plume looks like and then used mathematical modelling to see which plume scenario best fit the sample data. Using this data-driven approach, we show that the most likely scenario is a singular plume that pulses with different chemical compositions.

    The three rifts in Afar are spreading at different rates. The Red Sea Rift and Gulf of Aden Rift are moving faster at about 15mm per year (that’s half the rate your fingernails grow at) compared to the Main Ethiopian Rift moving at about 5mm per year . We deduced that the pulses are flowing at different speeds along the stretched and thinner undersides of the tectonic plates.

    All this shows us that the motion of tectonic plates can help focus volcanic activity to where the plate is thinner.

    This finding has important implications for how we interpret volcanic and earthquake activity. It may indicate that volcanism could be more likely to occur in the faster spreading and thinner portions of the rift, as the flow beneath replenishes the magma more frequently.

    However, the eruptions here may be less explosive than the slower spreading rifts. This fits observations that explosive eruptions occur more frequently in the Main Ethiopian Rift (which sits on a thicker part of the plate and where the volcanoes are more mature), compared to the Red Sea Rift.

    Our understanding of the link between continental rifting and mantle plumes is still in its infancy but research is already providing insights into how tectonic plates affect mantle plumes and how this might be recorded in the future seafloors of Earth.

    Emma Watts works for Swansea University. She receives funding from Natural Environment Research Council and the UK Research Council.

    Derek Keir works for the University of Southampton. He receives funding from the Natural Environment Research Council.

    Thomas Gernon works for the University of Southampton. He receives funding from the WoodNext Foundation, a donor-advised fund program, and from the Natural Environment Research Council.

    /Courtesy of The Conversation. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).

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  • SMD Quantum Technology Day 2025

    SMD Quantum Technology Day 2025

    The NASA Science Mission Directorate (SMD) sponsored a Quantum Technology Day to share information about SMD’s quantum technology efforts and quantum efforts other organizations are undertaking that may be relevant to NASA.

    Location

    NASA Headquarters, Washington DC

    Agenda and Presentations

    Wednesday, July 9, 2025

    0930: Quantum Technology in SMD

    1030: Quantum Inspired Telescope Imaging—Dr. Michael Nayak (DARPA)

    1300: Quantum Technology in Space—Prof. Robert Malaney (U. South Wales, Australia)

    1430: Quantum Information Processing for SMD—Dr. Eleanor Rieffel and Dr. Lucas Bradywood (NASA Ames)

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  • Gigantic ‘fortresses’ found deep underground in Earth’s mantle

    Gigantic ‘fortresses’ found deep underground in Earth’s mantle

    Geologists have stumbled on what they call gigantic fortresses lying almost 1,800 miles below our feet in Earth’s mantle.

    New seismic evidence shows how these subterranean bulwarks are older and tougher than the cooler debris of dead ocean plates that surround them, turning a long‑running mystery into a concrete data story.


    Each fortress spans an area comparable to a continent beneath Africa and the Pacific, and registers hotter than its frigid surroundings.

    Utrecht University‘s seismologist Arwen Deuss, working with colleagues across Europe, Australia, and the United States, led the crew that pieced together the picture.

    Fortresses in Earth’s mantle

    The scientific shorthand for the fortresses is large low seismic velocity provinces or LLSVPs, continent‑scale masses perched at the core‑mantle boundary about 1,800 to 1,900 miles down.

    They dampen shear waves and slow them, marking them out as zones of hot, sluggish rock that differs sharply from the stiff material around them.

    Seismic tomography first lit them up in global maps during the 1990s. Two hulking blobs emerged, one under Africa and one under the central Pacific, each more than 3,000 miles across.

    Later surveys confirmed that the African LLSVP towers roughly 600 miles high while its Pacific twin rises even farther.

    Yet whether they were temporary stains or ancient fixtures remained unsettled, in part because most models assumed vigorous, homogenizing flow in the lower mantle.

    Taken together, the two provinces occupy about eight percent of the mantle’s volume, a reminder that Earth’s interior is far from uniform.

    Listening to the planet’s bell

    Seismologists treat the Earth like a giant bell that rings when a great quake strikes. The catastrophic 1994 Bolivia event provided tones that hummed for hours, carrying clues from the deepest layers and offering clean, low‑noise data.

    “Large earthquakes make the whole Earth ring like a bell with different tones,” said Deuss after reviewing decades of records.

    Her team tuned in not only to the pitch shifts but also to how loudly each mode persisted, a seldom‑used metric called quality factor.

    That loudness, known as damping, revealed something odd. Vibrations grew quiet in the cold slab graveyard but stayed loud inside the hot fortresses, implying low internal friction and unexpectedly efficient energy transmission.

    Against expectation, the LLSVPs sapped little energy from the waves. The finding overturned the simple view that heat alone controls attenuation, forcing scientists to search for another variable.

    Texture tells a deeper story

    The key lies in grain boundaries, the microscopic seams between crystals in mantle minerals. Fewer seams mean fewer places for energy to bleed away, a principle familiar to anyone who has tried to push water through a coarse versus fine filter.

    Subducted plates recrystallize into tiny grains as they plunge, multiplying boundaries and soaking up seismic energy. They show up as the quietest patches in the global map, matching the high‑damping ring around the Pacific.

    Inside the fortresses, grains have had eons to grow fat. Large crystals line up like chunky bricks, stiffening the rock and letting waves glide through with little loss, a behavior confirmed in high‑pressure laboratory rigs.

    Laboratory tests on olivine confirm the trend, showing that doubling grain size can nearly halve seismic attenuation at mantle temperatures.

    That experimental curve fits the numbers seen in the new global model, strengthening the grain‑size explanation.

    Restless mantle and giant fortresses

    Modeling suggests the grain growth needed to reach that size takes at least 500 million years, perhaps far longer.

    The fortresses, therefore, predate many supercontinents that have since broken apart, including Pangea and its earlier cousins.

    Such rigidity helps them ignore the slow churn of mantle convection. They stand their ground while cooler slabs crawl and sink around them, like boulders lodged in a riverbed of flowing rock.

    “There is less flow in Earth’s mantle than is commonly thought,” Deuss explained, noting that the presence of these immovable masses forces scientists to rethink convection cycles. The textbook picture of a well‑stirred mantle no longer fits.

    A layered mantle, part conveyor and part castle, now seems more likely. That hybrid view changes every surface process driven from below, from the drift of continents to the cycling of carbon.

    Why the finding matters at the surface

    The hot edges of the fortresses appear to be launchpads for mantle plumes that punch up to volcano chains such as Hawaii. Their buoyant rise fuels not only island arcs but also the massive basalt floods seen in Earth’s deep past.

    Large igneous provinces linked to mass extinctions tend to cluster above these plume zones. Knowing that the plumes come from fortress margins ties surface cataclysms to deep‑mantle architecture.

    Mountain belts form where plates collide, but the deep heat flow that drives those collisions may trace back to these hot roots. In that sense, the fortresses could set the tempo of orogeny and rifting alike.

    Over geologic time, their stability may even shape the drift path of continents, steering plates around the mantle’s slow‑moving keystones. That possibility will feed new computer models that link deep convection to plate motions.

    What scientists will chase next

    Researchers plan denser global arrays and machine‑learning tools to catch fainter normal modes. Each new quake becomes another flashlight aimed into the depths, refining the 3‑D map with every event.

    Geochemists will compare volcanic rocks to lab‑made analogs, hunting chemical fingerprints of the fortresses.

    A match would close the loop between seismic images and real material, settling the debate over whether the fortresses differ in composition as well as temperature.

    Mineral physicists also want to recreate fortress conditions in diamond‑anvil presses, squeezing and heating samples to map how grain growth unfolds through deep time. The work could reveal why some minerals coarsen while others stay fine and brittle.

    Meanwhile, geoneutrino observatories may soon detect radioactive decay signatures that differ inside and outside the fortresses.

    Any contrast would add a new dimension to the planet‑sized puzzle, linking deep geology to particle physics.

    The study is published in Nature.

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  • Study casts doubt on a widely used shortcut in rectal cancer drug trials

    Study casts doubt on a widely used shortcut in rectal cancer drug trials

    A new study by a Tulane University researcher casts doubt on a widely used shortcut in rectal cancer drug trials, raising concerns that some treatments may be fast-tracked for approval without evidence they help patients live longer.

    The study, published in JAMA Network Open in collaboration with researchers at Mayo Clinic in Arizona, found that the absence of detectable tumors after treatment – a key metric in clinical cancer drug trials known as pathologic complete response or pCR – does not reliably predict an improvement in long-term survival for patients diagnosed with rectal cancer.

    Traditionally, success of treatments for these patients was determined by measuring “overall survival,” or the years between a person’s diagnosis and death. Since 2012, the U.S. Food and Drug Administration has allowed pharmaceutical companies to use tumor-free status post-therapy as a surrogate for overall survival to cut down on time and expenses needed to approve new cancer treatments.

    The researchers conducted a meta-analysis of 25 clinical trials involving nearly 12,000 rectal cancer patients. They found no statistical relationship between pCR and overall survival, meaning cancer drugs may be moving toward development without showing meaningful long-term improvements over existing treatments, said first author Kavin Sugumar, chief resident of general surgery at Tulane University School of Medicine.

    This is about patient outcomes, but it’s also about how we evaluate whether a new drug works. The FDA has approved pCR as a substitute for a result that would normally take years to determine, but we found that pCR should not be used as a sole endpoint to determine if a cancer treatment has been effective.”


    Kavin Sugumar, chief resident of general surgery, Tulane University School of Medicine

    PCR remains vital for effectively determining if cancer has been cleared locally from tissue, and patients whose tumors disappear often fare better than those who don’t.

    Still, the metric may fail to capture the full picture, such as whether the patient has lingering toxicity from chemotherapy or undetected cancer cells elsewhere in the body.

    The use of pCR as a gold standard for drug approval may also increase costs for drug companies which may invest in approved therapies that cannot guarantee improved survival rates.

    “Overall survival is a costly and time-consuming endpoint to determine, and I don’t think we’ve found the ideal surrogate yet,” Sugumar said. “Instead of relying solely on pCR, we should maybe include a combination of surrogate endpoints that also includes pCR.”

    Source:

    Journal reference:

    Sugumar, K., et al. (2025). Pathologic Complete Response and Survival in Rectal Cancer. JAMA Network Open. doi.org/10.1001/jamanetworkopen.2025.21197.

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  • 2025 British Open: There’s a Buddhist monk at the top of the leaderboard

    2025 British Open: There’s a Buddhist monk at the top of the leaderboard

    For some, golf is a path to spiritual enlightenment. For Sadom Kaewkanjana, spiritual enlightenment is a path to golf.

    Kaewkanjana, of Thailand, isn’t just an accomplished professional golfer; he’s an ordained Buddhist monk. And after one round of the 2025 British Open at Royal Portrush, he’s one stroke off the clubhouse lead at 3-under.

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    “Honestly, I play in my country, have no like links course before,” he said after his round. “So when I play links course, it’s a new experience for me. I really enjoy to play a links course. It’s fun to play with a windy course and tough conditions. So very enjoy to play on a links course.”

    A three-time winner on the Asian Tour, Kaewkanjana missed the cut in the two PGA Championships he’s played, and finished at T11 in the 2022 British. After that major, he stepped away from the game

    “I was ordained because I wanted to return the greatest merit and repay my parents,” he said at the time. “I was cut off from the rest of the world when I was ordained,” he added. “That made me feel more calm. I was able to concentrate more, which will help me improve my game of golf.”

    He qualified for this year’s Open by winning the Kolon Korea Open on the Asian Tour, and after his round, he discussed how his new calling has helped him prepare for these tournaments.

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    “It’s a new experience being a monk,” he said. “They help like more concentrate on the golf course or outside the golf course. It’s made me a lot of focus. Forget everything outside, just live in the present. So I really enjoy being a monk.”

    “Forget everything outside, just live in the present” is pretty much the most perfect advice possible for playing golf, but especially in a tournament of rain and wind like the Open. Kaewkanjana’s round included two birdies and an eagle against just one bogey.

    While the calm and serenity that comes from his ordination has helped him get to this point, the 27-year-old Kaewkanjana has some higher ambitions.

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    “My goal is like I want to play in the Masters my whole life,” he said. “I want to play one time. So to get in the world ranking into the top 50, that’s my goal.”

    Calm, serenity … and a tee time at Augusta National. That’s the secret to a full life right there.

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  • Martian meteorite sells for record $5.3 million at New York auction – The Times of Israel

    1. Martian meteorite sells for record $5.3 million at New York auction  The Times of Israel
    2. Largest Mars rock ever found on Earth sells at auction after $4.3m bid  BBC
    3. World’s biggest Mars rock sells for $5.3 million at auction  CNN
    4. Martian meteorite sells for record $5.3 million at Sotheby’s  Reuters
    5. Rocks from Mars and Bones from the Past: When a Dinosaur Outshined a Martian Treasure  Vocal

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  • ‘Worse for hospitality than Covid’: bosses blame Reeves’ budget for UK downturn | Hospitality industry

    ‘Worse for hospitality than Covid’: bosses blame Reeves’ budget for UK downturn | Hospitality industry

    “From a financial point of view, last year’s budget was worse for hospitality than Covid,” says Philip Thorley, who owns 18 pubs across Kent and employs around 400 people.

    Usually he is looking to recruit staff to help out in the summer months but this year will be different, he says, as the £25bn increase in employers’ national insurance contributions (NICs) that came into force in April has been “catastrophic for our company and industry”.

    He says the fact that Thorley Taverns is now taxed around £8,000 a week, totalling more than £400,000 a year, means they cannot afford to take on anybody new during busier months. Current staff will have to work harder, Thorley adds, and the added pressure could impact customer service levels and opening times.

    Philip Thorley said changes made in last year’s budget had stopped him hiring new people this summer. Photograph: handout

    “This affects anybody in retail, in the high street and other entry-level jobs, especially young people,” he says.

    After the chancellor, Rachel Reeves, announced the NICs rise in October, business groups argued that they would hit hiring and retention. On Thursday signs of that impact emerged in the latest official jobs data showing that unemployment climbed and wage growth slowed in the three months to May.

    The trade body for the hospitality sector said data showed it had been the hardest hit sector since the budget, accounting for 45% of all job losses. The chair of UKHospitality, Kate Nicholls, said: “The change to employer NICs in particular, was socially regressive and had a disproportionate impact on entry level jobs.”

    Cliff Nicholls, who runs two trampoline parks in Tamworth and Bolton, says his business rates have gone up 240% over what they paid last year, resulting in him cutting around 14 jobs.

    Due to high business rates increasing energy costs, Cliff has reduced opening hours, which is what he says is impacting his business the most.

    Jump Xtreme was open seven days a week all year round, but they have now had to close two days a week during term-time to save on bills.

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    The trampoline parks are in large buildings, which use more energy than most other local businesses, Cliff says. “Wholesale energy costs, which are largely outside government control, have gone up by 100% in the last four years,” he adds.

    “I’m hopeful, because the government indicated business rates will be reviewed in the next budget, but I’m not holding my breath given the government’s track record.”

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  • YSPH Study Reveals How Gene Expression Evolves < Yale School of Public Health

    YSPH Study Reveals How Gene Expression Evolves < Yale School of Public Health

    Researchers at the Yale School of Public Health have discovered the evolutionary rhythm of gene expression, showing that changes happen at strikingly varied rates.

    In the study, published in Molecular Biology and Evolution, “we found that some genes’ expression patterns remain virtually frozen in place for hundreds of millions of years, while others adapt quickly, evolving their expression rapidly,” said Dr. Jeffrey Townsend, PhD, the study’s senior author, Elihu Professor of Biostatistics and Professor of Ecology and Evolutionary Biology at YSPH. “Knowing these rates of evolution shows us which genetic functions are the unchanging heartbeat of life—and which are evolution’s improvisations.”

    A Molecular Clock for Gene Expression

    Gene expression—the process by which DNA is transcribed into RNA and then translated into proteins—is central to how organisms develop and respond to their environments. Evolutionary shifts in DNA sequence have been documented, but changes in gene expression have been harder to quantify over long periods of time.

    Knowing these rates of evolution shows us which genetic functions are the unchanging heartbeat of life—and which are evolution’s improvisations.

    Dr. Jeffrey Townsend, Yale School of Public Health

    To tackle this challenge, Townsend led a team of investigators that examined over 3,900 genes in nine fungal species with comparable biological developmental stages. The team used diverse fungi for their analysis because they are easy to grow in a common environment. Because the species were meticulously cultured under identical conditions, it allowed the scientists to measure only genetic, not environmental, differences.

    Lead author Yen-Wen Wang, PhD, a postdoctoral researcher in Townsend’s lab, applied sophisticated statistical models to infer how frequently gene expression doubled or halved across millions of years of evolution. For most genes, the time ranged from 400 to 900 million years. But some genes—particularly those involved in early spore germination—evolved much faster, in just 6.9 million years.

    “This early germination stage is ecologically crucial,” explained Wang. “Fungi must adapt rapidly to capitalize on distinct ways to colonize environments and rapidly acquire nutrients. Their early germination genes are under strong pressure to change.”

    At the Heart of Life, Essential Expression Endures

    By analyzing gene function across biological pathways, the researchers found that evolution tends to act more quickly on genes involved in flexible, responsive tasks—such as carbon metabolism—than enduring processes such as meiosis, a key aspect of sexual reproduction.

    “These findings reveal how the role a gene plays in development affects the pace at which its expression evolves,” Townsend said. “If a gene is part of an ancient, important, tightly regulated process like meiosis, it can’t accommodate change. But if it’s in a metabolic pathway that responds to environmental shifts, there’s more room for evolutionary experimentation.”

    Unlocking Life’s Potential

    The study establishes a powerful new framework for investigating gene evolution.

    “Knowing which genes evolve quickly or slowly in their expression enables us to precisely target genes that are optimal targets for functional characterization and applications in nearly all fields of life sciences,” Townsend said, adding that it could be useful in biotechnology applications ranging from agriculture to medicine.

    The work was funded by the U.S. National Science Foundation and National Institutes of Health. The data and methodological approach are publicly available. The researchers hope others will be inspired to expand our knowledge of gene expression in other key areas.

    “Ultimately,” Townsend said, “we want to understand how the choreography of gene expression — its timing, location, and intensity — has evolved to build the immense diversity of life we see today.”

    Transcriptome data from the study are publicly available in the Gene Expression Omnibus under PRJNA1171587 and PRJNA1177519.


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