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  • Catching up with Ralf Reichert, CEO of the Esports World Cup Foundation

    Catching up with Ralf Reichert, CEO of the Esports World Cup Foundation

    The Esports World Cup officially kicked off last week with its second annual tournament in Riyadh, Saudi Arabia, drawing over 2,000 competitors from 84 different countries. CEO of the Esports World Cup Foundation, Ralf Reichert, described the event’s $70 million prize pool as “by far the largest prize pool in the industry, and probably in almost all of sports”.

    And while in Riyadh last week, CNN’s Eleni Giokos caught up with Reichert, to hear more of his observations about this expanding industry.

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  • Fujifilm Introduces FUJIFILM Frontier DX400W Compact Inkjet Printer

    Fujifilm Introduces FUJIFILM Frontier DX400W Compact Inkjet Printer

    VALHALLA, N.Y., July 17, 2025 – FUJIFILM North America Corporation, Imaging Division, today announced the launch of its Frontier DX400W compact inkjet printer (DX400W). The latest addition to Fujifilm’s Frontier printer lineup, DX400W boasts improvements in printing output, including the addition of two new ink colors, as well as faster image processing/printing times and a smaller overall footprint[1].

    “We’re excited about the enhanced capabilities DX400W brings to the photo printing space,” said Bing Liem, division president, FUJIFILM North America Corporation, Imaging Division. “DX400W enables on-demand printing of not only standard photo prints, but also a wide range of photo products including photo books and calendars. Designed to meet the ever-evolving needs of our customers, DX400W enhances Fujifilm’s inkjet system lineup with the latest functionality and convenience.”

    Main Features:

    High-Image Quality and Capability to Print a Wide Range of Photo Products

    • Featuring a 250ml high-capacity 6-ink system consisting of C (cyan), M (magenta), Y (yellow), K (black), SB (sky blue) and P (pink), which enables more faithful reproduction of skin textures and subtle color changes.
    • Fujifilm’s proprietary image processing technology, IMAGE INTELLIGENCE™[2], draws on decades of expertise in the photography field to automatically correct underexposure, backlighting, high-contrast, underexposure, and overexposure issues, producing highly precise prints.

    Updated Design, Increased Efficiency

    • A new structural design increases the durability of the printer body, reducing the need for frequent hardware replacements and minimizing maintenance efforts. As a result of this design improvement, the printer can print a total of up to 400,000 sheets[3] over the lifetime of the product. Additionally, with a 30% reduction in size over the prior model, DX400W fits seamlessly into a variety of challenging spaces.

    Enhanced Usability for Diversified Printing Business Needs

    • In addition to USB connectivity, DX400W now supports wired LAN connections. The addition of LAN compatibility allows for more flexible functionality at retail, accommodating customer-specific installation environments. This not only improves convenience for retail photo shops but also caters to a wide range of applications in business and event settings, meeting diverse user needs.

    Reduced Waste with High-Capacity Ink

    • Ink capacity has been increased from 200ML in the prior model to 250ML in DX400W, improving operational efficiency by reducing the need for frequent ink replacement. Additionally, DX400W uses pouch-style ink supply units instead of traditional cartridge-based systems.

    The FUJIFILM Frontier DX400W photo printer will be available September 2025. For more information, please click here.

    About Fujifilm 

    FUJIFILM North America Corporation, a marketing subsidiary of FUJIFILM Holdings America Corporation, consists of six operating divisions. The Imaging Division provides consumer and commercial photographic products and services, including silver halide consumables; inkjet consumables; digital printing equipment, along with service and support; personalized photo products fulfillment; film; one-time-use cameras; and the popular instax™ line of instant cameras, smartphone printers, instant film, and accessories. The Electronic Imaging Division markets its GFX System and X Series lines of mirrorless digital cameras, lenses, and accessories to provide a variety of content creation solutions for both still and moving imagery. The Optical Devices Division provides optical lenses for the broadcast, cinematography, closed circuit television, videography, and industrial markets, and also markets binoculars and other optical imaging solutions. The Business Innovation Division offers a full lineup of digital print and toner technologies focused on enabling the digital transformation of businesses and print shops with its offerings of multifunction printers, digital inkjet presses, production toner printers, software, and more. The Industrial Products Division delivers new products derived from Fujifilm technologies including data storage tape products, including OEM and FUJIFILM Ultrium LTO cartridges, desalination solutions, microfilters and gas separation membranes.

    For more information, please visit https://www.fujifilm.com/us/en/about/region, go to https://x.com/fujifilmus to follow Fujifilm on X, or go to www.facebook.com/FujifilmNorthAmerica to Like Fujifilm on Facebook. 

    FUJIFILM Corporation is a subsidiary of FUJIFILM Holdings Corporation. FUJIFILM Holdings Corporation, headquartered in Tokyo, leverages its depth of knowledge and proprietary core technologies to deliver innovative products and services across the globe through the four key business segments of healthcare, electronics, business innovation, and imaging with over 70,000 employees. Guided and united by our Group Purpose of “giving our world more smiles,” we address social challenges and create a positive impact on society through our products, services, and business operations. Under its medium-term management plan, VISION2030, which ends in FY2030, we aspire to continue our evolution into a company that creates value and smiles for various stakeholders as a collection of global leading businesses and achieve a global revenue of 4 trillion yen (29 billion USD at an exchange rate of 140 JPY/USD). For more information, please visit: https://holdings.fujifilm.com.

    For further details about our commitment to sustainability and Fujifilm’s Sustainable Value Plan 2030, click here.  

    FUJIFILM, IMAGE INTELLIGENCE, and instax are trademarks of FUJIFILM Corporation and its affiliates.

    © 2025 FUJIFILM North America Corporation and its affiliates. All rights reserved.

    [1] When compared to FUJIFILM Frontier DX100.

    [2] Image Intelligence™ can be used by connecting workflow management software (MS Software) with the printer.

    [3] The number of printable sheets varies depending on usage conditions.

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  • Astronomers may have found 100 ‘undetected’ galaxies orbiting Milky Way

    Astronomers may have found 100 ‘undetected’ galaxies orbiting Milky Way



    This representational image shows a view of the Milky Way. — Unsplash

    Scientists at Durham University in England have identified signs that up to 100 extremely faint galaxies (too dim to be spotted with current telescopes) may be orbiting the Milky Way. 

    These elusive objects, referred to as “orphan” galaxies, likely escaped detection because of their very low brightness.

    The team reached this conclusion using a cutting-edge approach that merges high-resolution supercomputer simulations with precise mathematical modelling. Their findings were shared at the Royal Astronomical Society’s National Astronomy meeting held in Durham on Friday, ABC News reported.

    The simulations suggest the presence of a hidden population of small galaxies clustered around the Milky Way. If future observations confirm this, it could significantly alter our understanding of the galaxy’s surroundings and the formation of cosmic structures!

    Isabel Santos-Santos, the lead researcher at Durham University’s Institute for Computational Cosmology, said: “We know the Milky Way has some 60 confirmed companion satellite galaxies, but we think there should be dozens more of these faint galaxies orbiting around the Milky Way at close distances.”

    If telescopes detect these galaxies, it would strongly support the Lambda Cold Dark Matter theory, the leading model of cosmology explaining how galaxies form and the large-scale structure of the Universe, researchers said.

    According to the model, galaxies form at the centres of massive clumps of dark matter known as halos. It also proposes that just 5% of the Universe is made up of ordinary matter, 25% is cold dark matter, and 70% is dark energy.

    Most galaxies in the Universe are low-mass dwarf galaxies that orbit larger ones like the Milky Way, astronomers said.

    These satellite galaxies have long challenged the Lambda Cold Dark Matter (ΛCDM) model, which predicts more companions than previous simulations could explain. However, the new technique enabled researchers to trace the number, spread, and characteristics of these faint “orphan” galaxies more accurately.

    The model provides a “clear illustration” of the power of physics and mathematics, said Carlos Frenk, a co-researcher at the Institute for Computational Cosmology.

    Current simulations lack the resolution to study faint satellite galaxies and their dark matter halos, leading to gaps in data, researchers said. If the predictions hold true, it would strengthen the Lambda Cold Dark Matter model.

    Santos-Santos concludes, “One day soon we may be able to see these ’missing’ galaxies, which would be hugely exciting and could tell us more about how the Universe came to be as we see it today.”

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  • Planet-forming pebbles reveal the birth of a Solar System

    Planet-forming pebbles reveal the birth of a Solar System

    Astronomers just caught a celestial sneak peek at how solar systems are born, and it starts with something delightfully small: space pebbles.

    Around two young stars, DG Tau and HL Tau, tiny grains are gathering in vast pancake-like clouds called protoplanetary discs, stretching to Neptune-like distances. These pebbles are nature’s building blocks, slowly clumping into massive worlds over millions of years, just like how Jupiter, Saturn, and even Earth formed 4.5 billion years ago.

    These stars are located approximately 450 light-years away, quietly forming miniature versions of our cosmic neighborhood. It’s like watching the universe sketch out its next masterpiece, one pebble at a time.

    Astronomers peering into the deep space nurseries around young stars DG Tau and HL Tau have uncovered something spectacular: enormous reservoirs of planet-building pebbles stretching as far out as Neptune’s orbit, and possibly beyond. It’s like stumbling on a galactic blueprint for mega solar systems.

    Stellar winds help dust grains grow into planet-building pebbles

    Using the e-MERLIN telescope network, scientists created a detailed map of DG Tau’s disc, a tilted swirl of gas and dust. In this interstellar pancake, Pebble-sized clumps are gathering like early ingredients for world-making. The disc tilts southeast to northwest, showing a graceful spread of material and outflows from the star streak northeast and southwest, a sign of stellar winds shaping the neighborhood.

    Astronomers are taking on a cosmic detective mission with a bold new initiative called PEBBLeS, led by Professor Jane Greaves of Cardiff University. Their goal? To search the skies for rocky belts around young stars, places where new planets are being born.

    dust and tiny grains in a protoplanetary disc
    An artist’s impression of dust and tiny grains in a protoplanetary disc surrounding a young star (left) alongside an e-MERLIN map showing the tilted disc structure around the young star DG Tauri (top right) and the HL Tau disc captured by e-MERLIN is shown overlaid on an ALMA image, revealing both the compact emission from the central region of the disc and the larger scale dust rings. NASA/JPL-Caltech/Hesterly, Drabek-Maunder, Greaves, Richards, et al./Greaves, Hesterly, Richards, and et al./ALMA partnership et al.

    By imaging these dusty zones, the team hopes to discover how often and where planets form around stars destined to become suns like our own.

    To do this, they’re using e-MERLIN, a UK-wide radio telescope super-array comprising seven dishes that span 217 kilometers. Linked by lightning-fast fiber optics and coordinated from the iconic Jodrell Bank Observatory, e-MERLIN has the unique precision needed.

    Finding a cosmic fog within shattered intergalactic ‘pancakes’

    The observations enabled astronomers to pinpoint the region where solid material accumulates in the discs. Hence, it offers clues on one of the earliest stages of planet formation.

    Since the 1990s, astronomers have discovered thousands of fully-formed planets and swirling disks of space dust around young stars. These discs, packed with grains like cosmic sand, are the raw material for building planets.

    Early on, when the grains are spread out (sometimes across areas as large as Jupiter’s orbit), they’re easy to spot using infrared or submillimeter telescopes, such as ALMA.

    As the grains start to clump into planets, their surface area decreases. That makes them harder to detect; the more planet-like they become, the less visible they become.

    To spot the baby building blocks of planets, those centimeter-sized pebbles quietly gathering in young star systems, scientists need a telescope tuned to just the right wavelength. Enter e-MERLIN, the UK’s radio interferometer, which observes at 4 cm, the sweet spot for detecting these tiny future worlds.

    Using e-MERLIN, researchers discovered that DG Tau’s disc is brimming with pebbles even out to Neptune-like orbits. Also, there’s a similar belt of planetary seeds forming around HL Tau.

    These dusty discs aren’t just signs of planets-to-be; they’re early blueprints for solar systems that might be even bigger than our own.

    Looking ahead, the massive Square Kilometre Array (SKA) in South Africa and Australia will take this to the next level. With greater sensitivity and scale, SKA will unveil thousands of discs across the galaxy. Starting in 2031, SKA-Mid will begin verifying science and dive into studying hundreds of planetary systems.

    As Dr. Hesterly put it, e-MERLIN showed what’s possible; SKA will explore the galaxy’s wild imagination.

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  • Number of city rail commuters in England and Wales passes pre-Covid levels | Rail industry

    Number of city rail commuters in England and Wales passes pre-Covid levels | Rail industry

    The number of rail passengers travelling into cities in England and Wales has overtaken pre-Covid levels but changing work and travel patterns have eased overcrowding on the morning commute, official statistics show.

    Almost 1.9 million people took trains into cities on a typical weekday last autumn, the highest figure since the records were first collated in 2010.

    However, there were still about 13% fewer passengers arriving during the morning peak than in 2019, showing that the return to traditional nine-to-five office working remains some way off, despite recent pressure on staff from some firms.

    Arrivals into every station in London grew in the 12 months to autumn 2024, with particularly rapid growth at Paddington and Liverpool Street stations, both served by the Elizabeth line. The data suggests that the line, fully opened in 2023, has taken the pressure off other trains, with overcrowding in the capital down from 2019 levels.

    Now busier trains into Birmingham are matching London for the squeeze on commuters, according to the Department for Transport. Five Thameslink and West Midland services were the most overcrowded, with the 7.30am Bedford to Three Bridges having an 184% load factor – or almost twice as many passengers as seats – when it reached London St Pancras.

    Southwestern and Chiltern services made up the rest of the top 10 most overcrowded trains recorded by the DfT.

    The total number of people travelling into cities outside London remains below pre-pandemic levels, at about 660,000 daily arrivals compared with 730,000 in 2019.

    The DfT figures allow for standing capacity on many London commuter services, with almost one in four passengers standing on arrival in the morning.

    It found that average overcrowding – or “passengers in excess of capacity” – on midweek (Tuesday to Thursday) morning arrivals to the capital had increased slightly in the last 12 months to 1.6%, a figure now matched by Birmingham, with trains arriving at Bristol and Sheffield stations ranking as the next most crowded, after rapid growth in rail commuting last year.

    The DfT said that while directly equivalent statistics on crowding were not available, British rail passenger numbers appeared to be recovering faster than those in France, Germany or Italy, with growth of 9% last year compared with 5-7% in the three biggest EU economies.

    Public transport campaigners heralded the figures as underlining the return of rail, after passenger numbers dropped to as little as 5% of pre-pandemic levels in 2020, followed by pay freezes and industrial unrest.

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    Ben Plowden, of the Campaign for Better Transport, said: “Gloomy predictions for the future of rail at the time of the pandemic have proven wrong: rail is back in a big way, boosting our economy, keeping workers moving and saving our streets from gridlock.

    “The fact that passenger arrivals are up while overcrowding is down is partly due to the huge success of the Elizabeth line. With more bold projects like this we could transform cities and improve daily life for vast numbers of people. An expanded rail network combined with more affordable fares could really bring about a rail revolution.”

    Rail fares are expected to continue to rise above inflation, however, as revenue is still significantly lower than before the pandemic, with more people travelling off-peak.

    The report noted that Southwestern, once the railway’s most lucrative commuter network, had roughly two-thirds of its previous demand, now concentrated from Tuesday to Thursday.

    A number of businesses in the City, including banks and hedge funds, have been pushing staff to return full-time to the office in recent months. However, recruitment firms say workers fear the impact on their wellbeing, as well as the cost of commuting. Hybrid working is now the standard mode for more than a quarter (28%) of working adults in the UK, according to the Office for National Statistics.

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  • Scientists predict 100 hidden galaxies around milky way

    Scientists predict 100 hidden galaxies around milky way





    Scientists predict 100 hidden galaxies around milky way – Daily Times




































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  • How to clean keyboard grunge, earwax in earphones and screen smudges

    How to clean keyboard grunge, earwax in earphones and screen smudges

    LONDON (AP) — Smartphones, laptops, headphones and other electronic devices are essential for work and play in our daily lives. But all that time spent typing, scrolling or listening also means our devices gradually accumulate grime that needs to be cleaned off.

    You might not give much thought to cleaning your devices but there are reasons you should, says Logitech, which makes keyboards, webcams and other computer peripherals.

    “Regular cleaning and proper maintenance not only keeps your gadgets looking pristine, and wins you hygiene points, it also helps them perform better and last longer,” the company says. “In the case of devices like earbuds, the accumulated bacteria and debris may even cause health issues or discomfort.”

    Here are some pointers on cleaning your tech:

    Getting started

    Always check if the manufacturer has any specific guidelines for cleaning.

    Assemble some basic equipment and material for cleaning, which should include a soft and lint-free cleaning cloth, like a microfiber cloth; cotton swabs; a soft-bristled brush like a toothbrush, paintbrush or makeup brush; compressed air and isopropyl alcohol.

    Isopropyl, or rubbing alcohol, is a non-toxic cleaning solvent that’s antiseptic and antibacterial. It’s popular for cleaning electronics because it doesn’t leave any residue and dries quickly. But you might want to wear gloves to avoid skin irritation. Drip some of it on a cloth instead of pouring it directly onto your device. Also heed some of the more specific warnings below.

    Water and mild soap can be useful for cleaning dirty surfaces, but isopropyl alcohol is recommended for cleaning the internals of a device, said Alex Diaz-Kokaisl, senior technical writer at electronics repair company iFixit.

    “While there isn’t a hard-and-fast rule for cleaning electronics, we generally use high-concentration isopropyl alcohol (more than 90%) because it evaporates quickly,” he said. “The faster a liquid evaporates, the less likely it is to affect any components that conduct electricity.”

    For whatever device you’re cleaning, disconnect or power it off first. Remove any cases, plugs, covers and accessories.

    Computers and laptops

    When using a computer, the keyboard and mouse are the parts that are touched most often and therefore need the most frequent cleaning. And all those crevices between a keyboard’s keys are sure to catch crumbs.

    To remove any loose debris, iFixit’s official in-house cleaning guide recommends using a can of compressed air. Run the spray back and forth across the keys to blow out any bits. If possible, hold the keyboard upside down so the debris falls out.

    If you don’t have compressed air, Logitech suggests using a hair dryer on the cold air setting. Some social media users also recommend a handheld balloon pump.

    Next, dampen a cleaning cloth with water and gently wipe down the keyboard and mouse.

    Logitech says you can also use rubbing alcohol but recommends you test it first on an inconspicuous spot to make sure it doesn’t cause discoloration or scrub the lettering off the keys.

    Anti-bacterial baby wipes can also work on devices like a mouse, Diaz-Kokaisl said.

    “There shouldn’t be enough liquid to seep through cracks in the shell, and their residue typically evaporates faster than just using soap and water,” he said.

    For laptop screens or external monitors, use a dry microfiber cloth to gently wipe away fingerprint smudges.

    If there are more stubborn spots — like food stains or sneezy spatters — dampen the cloth with distilled water or a 50/50 solution of distilled water and vinegar.

    Computer maker Lenovo says the “gentle acidity of vinegar can help break down oils and fingerprints.” Avoid using household glass cleaners, which can contain ammonia that could damage the screen. The same goes for paper towels, which can scratch the screen. HP also warns against using rubbing alcohol.

    AirPods and earphones

    A lot of people listen to music or podcasts through their earbuds, but that also means they’ll need regular cleaning to remove any earwax, natural skin oils or other grungy buildup.

    If the earbuds have silicon tips, remove them. Cleaning procedures vary depending on your brand and model. Logitech and Bose recommend using soapy water. But Sony warns against water or wet wipes because they can speed deterioration, and, instead, advises using a dry cloth.

    Use a cotton swab to wipe the earbud nozzles clean.

    Owners of Apple AirPods need to follow a much more elaborate procedure to clean the mesh. You’ll need a child’s toothbrush, two small cups, a paper towel, distilled water, as well as micellar water — typically used as a facial cleanser.

    Pour some micellar water into a cup, dip the toothbrush, brush the AirPod’s various mesh parts, and then blot them dry with the paper. Repeat twice. Then repeat that procedure but using the distilled water to rinse off the micellar water. Finally, let the AirPods dry for at least two hours.

    To clean the rest of the AirPod’s body, use a damp cloth. And don’t forget about the charging case. Apple recommends brushing out any debris and then wiping with a dry cloth. If needed, dampen it with isopropyl alcohol.

    What about over-the-ear headphones? Bose says you should wipe them down at least once a week, especially after working out, to remove any dirt and bacteria hiding in the nooks and crannies. Remove the pads and use a cloth dampened with soapy water to clean them.

    Smartphones

    Apple has issued specific instructions on its website for cleaning various iPhone models. Samsung has posted similar guidelines for its Galaxy lineup.

    They both advise using a soft, lint-free cloth, such as a lens cleaning cloth, to gently wipe the outside of the phone. Apple warns against using any cleaning products, which could erode the oil-repellent coating that most iPhones come with.

    Both companies say it’s OK to use disinfectants such as rubbing alcohol to gently clean the exterior, but avoid bleach or hydrogen peroxide.

    ___

    Is there a tech topic that you think needs explaining? Write to us at [email protected] with your suggestions for future editions of One Tech Tip.

    Kelvin Chan, The Associated Press


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  • Palace takes urgent action as Harry, Meghan plans leak in privacy breach

    Palace takes urgent action as Harry, Meghan plans leak in privacy breach



    Palace takes urgent action as Harry, Meghan plans leak in privacy breach

    Tensions are running high at Buckingham Palace as the top aides of the monarch were grasping at straws to stop a major leak from happening.

    Three weeks ago, The Telegraph published a report in which Prince Harry and Meghan Markle were “at the heart of the King’s funeral plans”. The funeral plans of the monarch are code named as ‘London Bridge’.

    The story about the ‘bridge plans’ was leaked by someone insider the Palace and it led to the a “huge censorship operation” to “contain the spill”, according to The Daily Beast.

    New details reveal that the king’s most senior aide, Tobyn Andreae, “had a meltdown on the phone” to editors at the Telegraph, a reliably pro-monarchy publication, about its London Bridge story.

    “These new details about London Bridge, including that Harry and Meghan will be invited for central roles and that the mourning period will be shortened, had found their way to the Telegraph exclusively,” said a well-placed Fleet Street source.

    “There was a conversation with the palace’s communications team ahead of publication.”

    Tobyn “was very, very, unhappy” as tried to convince the outlet to change the timing of the article with the outlet but the editors were determined to stick to their editorial independence. The top aide believed that the story was “premature”.

    As the publication proceeded to publish the exclusive story, Tobyn, who met with the Sussexes top aides in an informal meeting in London last week, issued a warning to other newspapers about even quoting the Telegraph report.

    The King’s aide did not confirm the accuracy of the claims but vehemently denied that there was any active funeral planning underway for the monarch getting weekly cancer treatments.

    He noted in a series of WhatsApp messages, via The Daily Beast, that the report is “deeply distasteful in normal circumstances” but “downright offensive” given the King is doing well.

    Tobyn warned the outlets that “no matter how ‘sensitively framed’” the article is, the Palace will “not assist media with operational planning” if newspapers published “speculative pieces about Bridges planning, whatever the source”.

    The update comes after Tobyn was seen meeting the Duke of Sussex’s chief of staff and communications director, Meredith Maines, and the Sussexes’s U.K. spokesperson, Liam Maguire, at a London’s private club near Clarence House.

    It is possible that the summit had been to discuss the security breach and how to deal with the new piece of information. Although, speculations of a reunion began after the meeting given that the monarch and his younger son have not been speaking since more than a year.

    It remains to be seen how the events will unfold over the next few weeks until Harry touches down in London in September.

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  • Study Reveals New Clues in Liver Disease Prevention | Newsroom

    Study Reveals New Clues in Liver Disease Prevention | Newsroom

    The aging liver undergoes dramatic changes in its functional organization and other key attributes, which may underpin its increasing susceptibility to disease, according to a study led by investigators at Weill Cornell Medicine. The findings suggest the possibility of future therapies that would block or reduce such changes to treat or prevent age-related chronic liver diseases—effectively making the liver more youthful and resilient.

    In the study, published on July 4 in Hepatology, the researchers compared gene activity and other features of the cells in aged versus young mouse livers. Among the major aging-related changes they observed were enlargements of many liver cells, inflammation and blurring of the functional zones of normal livers. The researchers observed similar changes when comparing older and younger human livers.

    “Do these changes underlie the aging liver’s reduced ability to metabolize drugs, neutralize toxins and resist liver disease?” said study senior author Dr. Robert Schwartz, an associate professor of medicine and the Irma Hirschl Trust Research Award Scholar at Weill Cornell Medicine and a hepatologist at NewYork-Presbyterian/Weill Cornell Medical Center. “That’s the big question we now intend to investigate.”

    Dr. Robert Schwartz

    The liver’s essential functions include filtering the blood and storing metabolites and nutrients. It does have the ability to regenerate itself, which has encouraged the view that it is less affected by aging than other organs. But chronic liver diseases, especially metabolic dysfunction-associated steatotic liver disease (MASLD), are more likely to develop as people age, and in general are extremely common—one recent study suggested that the condition affects 30 to 40 percent of the U.S. population. MASLD also can develop into severe, inflammatory forms leading to cirrhosis and cancer. Yet the molecular underpinnings of such age-related liver conditions are poorly understood.

    In the study, Dr. Schwartz’s team used a variety of tools to take a fresh look at the differences between aged and young livers. While the livers of two-year- and two-month-aged mice were similar in weight and overall appearance, comparison under a microscope showed that the cells in aged livers were much larger on average, with marked deposits of lipofuscin, a substance known to accumulate in, and potentially damage, aging cells.

    Some of the most striking findings came from single-nucleus RNA sequencing, a relatively new method that allows scientists to profile gene activity in essentially all cell types in a tissue sample. This study is thought to be the first that applies the technique to understand liver aging. The resulting dataset on gene activity in tens of thousands of liver cells revealed that aging has a strong impact on the usual functional organization or “zonation” of hepatocytes, the main type of liver cell.

    “In young, healthy livers, hepatocytes perform distinct functions in distinct zones in the liver with different proximities to blood supply, but in aged livers this zonation is lost,” said study first author Dr. Saloni Sinha, a postdoctoral research associate in the Schwartz laboratory. “We suspect this impairs the liver’s functions and its ability to respond to stress or injury.”

    The RNA sequencing showed that there are significant aging-related differences in the activity levels of hundreds of genes in dozens of distinct liver cell types. Analyses of these differences pointed, among other things, to higher levels of inflammation and the non-dividing, pro-inflammatory cell state known as senescence. Scientists in recent years have come to see the accumulation of senescent cells and associated inflammation—“inflammaging”—as a major driver of tissue aging and disease susceptibility.

    The researchers confirmed the likely relevance of their mouse findings to human biology with similar findings in biopsies of livers from younger and older people.

    The data generated in the study represent a significant new resource for scientists who study liver biology. Dr. Schwartz, who is also a member of the Weill Cornell Medicine Sandra and Edward Meyer Cancer Center, and Dr. Sinha hope it will lead them to new strategies for keeping aged livers younger and healthier.

    Many Weill Cornell Medicine physicians and scientists maintain relationships and collaborate with external organizations to foster scientific innovation and provide expert guidance. The institution makes these disclosures public to ensure transparency. For this information, see profile for Dr. Robert Schwartz.

    This research was supported in part by grants from the National Cancer Institute, the National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases, all part of the National Institutes of Health, through grant numbers R01CA234614, R01AI107301 and R01DK121072. Additional support was provided by the department of Defense through grant number W81XWH-21-1-0978, and from The Paul G. Allen Family Foundation UWSC13448.

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  • England Men U19s squad announced for Second Youth Test

    England Men U19s squad announced for Second Youth Test

     

    England have announced their squad for the second U19s Youth Test match against India set to be played at the Ambassador Cruise Line Ground.

    Tickets and Hospitality are on sale for the four-day Second Youth Test Match which will begin in Chelmsford on Sunday 20 July.

    A 14-player squad has been selected for the second Youth Test which begins on Sunday at Chelmsford, with Will Bennison, Ben Dawkins, Joe Hawkins, and Adam Thomas being added.

    England U19s Men Youth Test squad:

    Thomas Rew (Somerset – captain)
    Ralphie Albert (Surrey)
    Will Bennison (Yorkshire)
    Ben Dawkins (Kent)
    Rocky Flintoff (Lancashire)
    Alex French (Surrey)
    Alex Green (Leicestershire)
    Joe Hawkins (Derbyshire)
    Jack Home (Worcestershire)
    Ben Mayes (Hampshire)
    James Minto (Durham)
    Aaryan Sawant (Middlesex)
    Jay Singh (Yorkshire)
    Adam Thomas (Surrey).

    India have also named their squad which includes 14-year old IPL sensation, Viabhav Suryavanshi, who has already made a big impression during the tour, smashing a 78-ball 143 during the one-day series at Worcester.

    India U19s Men Youth Test squad:

    Ayush Mhatre (captain)
    Vaibhav Suryavanshi
    Vihaan Malhotra
    Maulyarajsinh Chavda
    Rahul Kumar
    Abhigyan Kundu (Vice-Captain & WK)
    Harvansh Singh (WK)
    R S Ambrish
    Kanishk Chouhan
    Khilan Patel
    Henil Patel
    Yudhajit Guha
    Pranav Raghavendra
    Mohammed Enaan
    Aditya Rana
    Anmoljeet Singh

    Tickets

    Tickets are now on sale for all four days of the match via the Essex Cricket website. Don’t forget, the game is FREE to attend for all Essex Cricket 2025 Members. Simply show your Membership Card to gain entry.

    Members: Free

    Adults: £10

    Student/Young Adults (18-25): £10

    Junior (U18): £3


    Hospitality

    Hospitality is also available for the first three scheduled days of the match, starting from £54 per person and includes your match ticket.


     
    Head to the Seat Unique website to book your hospitality by clicking the button below or alternatively, please call Julie Ager on 01245 254063.

     


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