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  • Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US

    Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US

    A genomic analysis of US gonorrhea isolates shows a dramatic increase in tetracycline resistance.

    In a letter published this week in the New England Journal of Medicine, researchers from the Harvard TH Chan School of Public Health and the University of Georgia reported that their analysis of more than 14,000 publicly available Neisseria gonorrhoeae genome sequences collected through the Centers for Disease Control and Prevention’s N gonorrhoeae surveillance system from 2018 through 2024 show that the percentage of isolates carrying the tetM resistance gene rose from 10% in 2020 to more than 30% in 2024. The tetM gene confers high-level resistance to tetracycline antibiotics.

    The analysis also found that the number of large tetM-carrying N gonorrhoeae lineages increased from one to four over the period. The researchers suggest that increased use of doxycycline for treatment of chlamydia infections and for doxycycline post-exposure prophylaxis (doxyPEP) may be playing a role.

    Resistance increase tied to doxyPEP rollout

    “The increase in tetM prevalence in 2020 coincided with the shift away from azithromycin and toward doxycycline for treatment of chlamydia, and the increase that started in the summer of 2022 coincided with the reporting of the results of the DoxyPEP trial,” the researchers wrote, citing a conference abstract

    The highest prevalence of tetM-carrying N gonorrhoeae was in the Pacific Northwest. Seattle was also one of two cities (along with San Francisco) in which a large randomized clinical trial of doxyPEP was conducted. It was among the earliest adopters of doxyPEP for the prevention of sexually transmitted infections (STIs) for high-risk groups.

    The increase in tetM prevalence in 2020 coincided with the shift away from azithromycin and toward doxycycline for treatment of chlamydia, and the increase that started in the summer of 2022 coincided with the reporting of the results of the DoxyPEP trial.

    The doxyPEP trial, conducted from August 2020 to May 2022, found that taking a dose of doxycycline within 72 hours of unprotected sex significantly reduced incidence of chlamydia and syphilis by 88% and 87%, respectively, and gonorrhea by 55% in men who have sex with men (MSM) and transgender women. Public health departments in San Francisco and Seattle began recommending the strategy for these groups shortly after the trial results were announced in the summer of 2022.

    The data from the doxyPEP trial and other clinical trials formed the evidence base for the CDC’s recommendation of doxyPEP for gay, bisexual, and other MSM and transgender women in June 2024. Agency officials hailed it as the first new prevention tool against STIs in decades.

    Concerns about highly drug-resistant gonorrhea strains

    To date, several studies have shown doxyPEP to be highly effective in real-world settings against chlamydia and syphilis and moderately effective against gonorrhea. But the new study is the latest to add to concerns that doxyPEP use may be promoting tetracycline resistance in gonorrhea—a result that even proponents of the strategy have said needs to be monitored. 

    Although doxycycline is no longer used to treat gonorrhea, rising tetracycline resistance could reduce doxyPEP’s already limited effectiveness at preventing gonorrhea infections. There’s also concern about tetracycline resistance in “off-target” bacteria.

    In a study published earlier this year, researchers with the University of Washington found that, among gonorrhea isolates collected at a sexual health clinic in Seattle, the prevalence of tetracycline resistance genes rose from 27% in 2017 to 70% by the middle of 2024. They also found that colonization with tetracycline-resistant Staphylococcus aureus and group A Streptococcus bacteria—which are often present in the body sites where N gonorrhoeae is found—was more common among doxyPEP users than non-users.

    “Public health authorities should implement additional surveillance monitoring to assess the impact of doxy PEP implementation on bacterial colonization and AMR [antimicrobial resistance], including monitoring for clinically significant events related to doxy PEP induced changes in patients’ microbiomes,” the authors of that study concluded.

    Concerns over potentially untreatable gonorrhea

    Another concerning finding in the new study is that of the four major tetM-carrying N gonorrhoeae lineages identified, two carry mutations in another gene (penA) that confer high-level resistance to ceftriaxone, which is the currently recommended treatment and last remaining effective antibiotic for gonorrhea. The strains are also resistant to fluoroquinolone and macrolide antibiotics. 

    China and other countries in Asia have reported increases in incidence of these highly drug-resistant gonorrhea strains in recent years, raising concerns about the potential for untreatable gonorrhea.

    “The strength of selection in the United States for tetM, as indicated by the increasing proportion of isolates that carry the gene and the expansion of major tetM-carrying lineages, suggests a favorable environment for these highly drug-resistant strains to spread within the country and highlights the need for continued surveillance,” the researchers wrote.

    To date, the United States, Germany, Australia, and the United Kingdom are the only countries to officially recommend use of doxyPEP for the prevention of STIs. But in a report published last week in Eurosurveillance, Dutch researchers noted that informal use of doxyPEP in the Netherlands has been rising, despite lack of formal guidance from the Dutch health officials. They warned that lack of monitoring and regulation could lead to overuse and misuse.

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  • Taylor and Clarke of ‘Love Island USA’ On Their Relationship Status Now

    Taylor and Clarke of ‘Love Island USA’ On Their Relationship Status Now

    Taylor Williams and Clarke Carraway may have been voted out of the “Love Island USA” villa, but they say that hasn’t impacted the status of their relationship.

    “We’re still the same as we were in the villa,” Taylor tells TODAY.com. “That’s why I used the word exclusive instead of closed off. Closed off is a villa term. You’re not in the outside world saying, ‘We’re closed off.’”

    Before choosing to become exclusive in Episode 32, Taylor and Clarke met in Episode 19, when the girls on the show were sequestered in Casa Amor and five new female bombshells, including Clarke, entered the villa. While Clarke was initially coupled up with Taylor’s friend Nic Vansteenberghe, during Episode 20’s recoupling, Clarke and Taylor chose to give their connection a chance.

    Taylor tells TODAY.com he realized he was serious about exploring his relationship with Clarke by their second conversation.

    “We had a conversation, and she pulled me to talk to me and was like, ‘I want to let you know that I’m interested in you, that I like, you know, I want to get to know you,’” Taylor recalls. “And I was like, ‘OK, cool, after we get ready.’

    “And then we ended up talking like the rest of the morning. I was like, ‘What the hell? I haven’t gotten ready yet,’” he adds.

    Clarke says after meeting Taylor, “the conversation just flowed.” She describes one moment when she, Taylor as well as Casa couple Ace Green and Courtney “Coco” Watson had a “therapy session.” During this exercise, Ace and Coco asked them about their connection and their plans for the future before swapping.

    “That was fun, and then I was like, ‘My feet hurt,’ and then he took my shoes off for me,” she adds with a laugh.

    Clarke Carraway and Taylor Williams on “Love Island USA” Season 7.Peacock

    What Happened Between Taylor and Olandria?

    Before Casa, Taylor had been coupled with Olandria Carthen since Day 1 in the villa. But while in Casa, she was temporarily voted off the show after she wasn’t selected for a couple by the group of boy bombshells. At the same time, Nic was dumped from the villa.

    Or, so they thought.

    Episode 20 ended on a massive cliffhanger. As Nic left the villa, suitcase in hand, a black SUV pulled up, with Olandria inside. In the next episode, they were whisked off to a date and given the option to leave the show or couple up.

    At the same time as Nic and Olandria became the villa’s newest couple, Taylor was pursuing his connection with Clarke. Taylor confirms Nic had expressed interest in Olandria before they were officially coupled up.

    “He’s always told me he’s super attracted to her, but he never tried to explore it,” Taylor says, citing Nic’s first connection with Belle-A Walker, followed by Cierra Ortega. (Nic and Cierra chose to close off their relationship in Episode 25, then Cierra left the villa in Episode 30 after viewers resurfaced old posts in which she used racial slurs. Cierra apologized via a video she shared to social media July 9.)

    Taylor adds that Nic had a conversation with him about being coupled with Olandria.

    “They came back, and we’re sitting in the room. I was sitting next to him, and he asked me if I cared if he explored Olandria,” Taylor says. “I was like, ‘No, go ahead. I can’t get mad if you’re exploring Olandria and I’m exploring Clarke.’”

    When the girls came back from Casa, there was yet another recoupling, and Taylor had to choose between Olandria and Clarke. Taylor ended up choosing Clarke, citing the different feeling she gave him.

    Olandria was left single, before coupling up with Nic again in Episode 30 after Cierra left the villa. Clarke and Taylor meanwhile continued to grow their relationship, from having a picnic date to an energetic proposal for exclusivity.

    When asked for her favorite moment in the villa, Clarke makes Taylor guess.

    “The cheer?” Taylor says, as Clarke confirms with a laugh.

    In Episode 32, after the guys had a day of playing 3 v. 3 basketball, Taylor enlisted his fellow Islanders to help him ask Clarke to be exclusive via a cheer that involved spelling out her name. It started with Taylor opting to give that night’s toast, and Clarke remembers thinking, “I’ve never seen you do a toast, this is going to be fun.”

    “And then they start spelling everything out, and it gets to C-L, and I’m like, ‘Oh my god, is this about to say my name right now?’” Clarke says. “I was just like speechless. I could not stop laughing. And they’re doing cartwheels and flips … I loved it.”

    That night, the couple was dumped from the villa after receiving the fewest amount of fan votes. Taylor says he wasn’t surprised. A viewer poll from Episode 27 consistently resulted in Clarke and Taylor coming last in categories like “most genuine” and “best boyfriend material.”

    “Everything happens for a reason, so I can’t be mad at it,” he says. “You know I could be upset, but it’s like I can’t be absolutely mad because this happened for a reason.”

    Love Island USA - Season 7
    Couples Nic and Olandria and Clarke and Taylor stand in front of the fire pit of the villa before the dumped Islanders were announced.Peacock

    But is there anything they would have done differently in the villa?

    “Not for me,” Clarke says.

    “Yeah, no, I would have rocked out the same way I did, to be honest,” Taylor agrees. “I had a hell of a time in there. If I could do it again, I would do it the same way.”

    What’s Next for Clarke and Taylor?

    Taylor says their exclusive relationship is “something that I see on the outside world and something that I want to keep growing on the outside world.”

    But the two have quite the distance between them. Taylor is from Oklahoma City, Oklahoma, while Clarke is from Charlotte, North Carolina.

    Clarke confirms they have plans to maintain a long-distance relationship.

    “I’m going to go to Oklahoma and do the rodeo situation, and then he’s going to come visit me in Charlotte,” she says. “Definitely, like a lot of traveling, but things to look forward to.”

    Love Island USA - Season 7
    Clarke Carraway and Taylor Williams left the villa in Episode 32 of “Love Island USA.”Ben Symons / Peacock

    Taylor says he’s excited to introduce Clarke to “rodeo world,” “horses” and “country life.”

    Meanwhile Clarke says she wants to introduce Taylor to “city life,” such as “fine dining.”

    “You make it seem like I eat bugs for a living,” he jokes through laughter. “I’ve got that s—, too.”

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  • The Space Traffic Report: Starlink, ISS docking, and upcoming Falcon 9 & Kuiper launches

    The Space Traffic Report: Starlink, ISS docking, and upcoming Falcon 9 & Kuiper launches













    The Space Traffic Report: Starlink, ISS docking, and upcoming Falcon 9 & Kuiper launches – NASASpaceFlight.com























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  • Why solar power might be our best shot against climate calamity

    Why solar power might be our best shot against climate calamity

    Despite the end of solar panel tax incentives under President Trump’s One Big Beautiful Bill Act, globally, solar is having a moment. The World Economic Forum reported that renewable energy capacity increased by 15.1% in 2024, with much of that driven by solar growth in China.

    “Some point in the last five years or so, we crossed an invisible line where it became cheaper to generate power from the sun and the wind than it did from setting coal and gas and oil on fire,” said author and environmentalist Bill McKibben. “That’s an epochal moment in human history.”

    In his upcoming book, “Here Comes the Sun: A Last Chance for the Climate and a Fresh Chance for Civilization,” McKibben looks at how the explosive growth of the solar industry could pave the way for a more climate-resilient future. McKibben spoke with “Marketplace” host Amy Scott about the book; the following is a transcript of their conversation.

    Amy Scott: So why solar? Why is that a last and maybe our best chance at avoiding climate calamity?

    Courtesy W. W. Norton and Company

    Bill McKibben: You know, I’ve been working on climate change for a very long time, Amy. I wrote the first book for a general audience about what we then called the greenhouse effect back in the 1980s and the first hint that we’ve actually had of something that’s scaling fast enough to make even a small difference in how hot this planet gets has been the explosion in the last two years of the amount of solar power on this planet. Last year, 95% or so of new electric generating capacity came from the sun and the wind, and that’s remarkable. You can see it happening everywhere. It’s centered in China, which is building about half the clean energy on the planet. Forget petrostates, they’re now the world’s first ‘electrostate.’

    Scott: I mean, it’s really remarkable. Why has this happened in just the last couple of years?

    McKibben: Money, money, money. Some point in the last five years or so, we crossed an invisible line where it became cheaper to generate power from the sun and the wind than it did from setting coal and gas and oil on fire. That’s an epochal moment in human history. We really could wind down combustion quickly on this planet, saving something of the climate, preventing millions of deaths a year from breathing the bad effects of that combustion, and, not in a minor way, we could also take some of the pressure off the geopolitics of this earth. It’s pretty hard to fight a war over sunshine.

    Scott: But the myth that solar is expensive is so pervasive. You write it’s considered like the full the Whole Foods of energy, but actually it’s more like Costco. Why is that so sticky?

    McKibben: Well, it’s because it’s been true for 40 or 50 years. Ever since we started talking about this stuff, we’ve called it alternative energy, and that’s because fossil fuel was always, and remains, fairly cheap. But activists and government policy makers set the conditions that began to allow demand to build, and as that demand built across the world, but especially in China, people figured out how to make really cheap solar panels. There’s now parts of Europe where people are putting up solar panels instead of fences, because it’s cheaper than buying good wood. It’s only in the US where we’re, at least for the moment, determinedly turning our back on all of that.

    Scott: Right? We have to talk about the 900-page Republican tax cut and spending bill known as the ‘One Big, Beautiful Bill,’ that became law and will essentially remove incentives for solar power here in the United States. How big of a setback is that for the overall energy transition?

    McKibben: It’s a huge setback for the American role in that energy transition, but in the long run, it’s probably going to be at least as big a problem for us economically. We’re essentially ceding the future to the Chinese, and it’s possible that 20 years from now, the U.S. will be a kind of museum of coal-fired power plants and internal combustion engines, while the rest of the world has moved on to cheap, clean technology. That would be a great shame, and it’s not inevitable. Even with the current powers that be, there’s a lot that can be done at the state and local level to surge ahead with renewable energy, even while Washington is sticking its head as far down the sand as it can get.

    People protest against fossil fuels outside of the White House

    McKibben, center, at a protest outside of the White House.

    Courtesy McKibben

     Scott: As you mentioned, China is leading the solar revolution, leaving the United States behind. You’ve been to China’s Solar Valley. What did you see there?

    McKibben: Well, I’ve been to China a bunch of times and watched different phases of this, including the very early ones. The Chinese figured out early on that this was where the future lay, and that’s why now the pace at which they’re doing this is truly incredible. In May of this year, China was putting up a gigawatt’s worth of solar panels, and a gigawatt’s worth of solar panels is the rough equivalent of a nuclear or a coal-fired power plant, they were doing that every eight hours. Can you imagine building a nuclear plant every eight hours? That’s essentially what they were doing, and they’ve coupled it, of course, with the technologies to take full advantage of all that electricity.

    Scott: All this kind of makes you wonder, does the world even need the U.S. to be fully on board? Can we get to a livable climate ceiling without U.S. involvement?

    McKibben: The problem is not only that we’re still second-biggest source of carbon in the world, but also that the other thing that the Trump administration is doing is trying very hard to sell our fossil fuels abroad. For the moment, we’re going to have to do this without the help of Washington. But that doesn’t mean we can’t do it. You know what state in America is putting up renewable energy far faster than any other?

    Scott: I do know the answer, but yeah, it’s a surprise.

    McKibben: The Lone Star state of Texas and and it’s because they understand the economics of it. That’s what’s keeping their rapidly expanding grid affordable and, probably just as importantly, reliable.

    Scott: I was telling my producer before we started that reading the book is kind of an emotional roller coaster. It’s at times extremely hopeful and also very depressing. At the end of the book you write that when you finished writing your first book about climate change, “The End of Nature,” you felt catatonic. But after this book, 40 years later, you felt a combination of sadness and exhilaration. Why exhilaration?

    McKibben: Well, at the prospect that there’s finally something we can do that can scale. I’m sad because of all that we’ve already lost and will continue to lose, but we finally have something that, if we decided to do it at the pace that it’s possible to do it at would get us somewhere.

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  • Former Real Madrid manager mentioned in Pandora Papers receives suspended jail term in tax fraud case

    Former Real Madrid manager mentioned in Pandora Papers receives suspended jail term in tax fraud case

    A court in Madrid has sentenced Carlo Ancelotti to a one-year suspended prison term and fined him 386,362 euros (over $450,000) for tax fraud while he was manager of Real Madrid in 2014.

    Spanish prosecutors accused Ancelotti, 66, of defrauding the state of 1 million euros (over $1 million) in undeclared earnings from image rights in 2014 and 2015, The Guardian reported. Image rights grant the right to control how one’s image is used commercially and can be valuable.

    While prosecutors initially sought a prison sentence of up to four years and nine months on two counts of tax fraud, Ancelotti, who now coaches Brazil’s national team and no longer lives in Spain, will not serve jail time because the sentence is less than two years and he has no criminal record, ESPN reported.

    Ancelotti, who paid back the debt in full in 2021, testified that he had “never thought about committing fraud” and had left the handling of his financial affairs to advisers.

    The Italian is one of soccer’s most prolific and successful coaches. Besides Los Blancos and Brazil, he has coached Chelsea, Paris-Saint German, Everton,  Bayern Munich and AC Milan, and he has won the Champions League five times.

    Details of Ancelotti’s tax arrangements were revealed in the Pandora Papers, an investigation led by the International Consortium of Investigative Journalists with a team of more than 600 journalists from 150 news outlets that revealed the financial secrets of scores of world leaders, politicians and public officials, as well as a global lineup of fugitives, con artists and murderers.

    The two-year collaboration was based on a trove of more than 11.9 million confidential files leaked from 14 offshore services firms from around the world that set up shell companies and other offshore nooks for clients seeking to keep their financial activities in the shadows.

    El País reported in 2021 that the two companies Ancelotti used to receive payment for image rights were through a structure set up by employees of Trident Trust, an offshore service provider at the heart of the Pandora Papers document trove. With offices in the British Virgin Islands and operations in more than 20 jurisdictions, Trident Trust is one of the world’s largest offshore service providers.

    Ancelotti is the latest of several celebrities and sports identities to appear in ICIJ offshore investigations and to be pursued by Spanish tax authorities, including Shakira and Lionel Messi.

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  • Dollar strengthens against peers as Trump rekindles trade tensions; bitcoin hits record high – Reuters

    1. Dollar strengthens against peers as Trump rekindles trade tensions; bitcoin hits record high  Reuters
    2. US Dollar Forecast: A July rate cut by the Fed loses impulse  FXStreet
    3. No Erosion of US Reserve Currency Status  Forex Factory
    4. The USD moves higher as Trump tariff inflation risk increases  TradingView
    5. Bitcoin – Dollar Edges Up As Trump Unveils New Tariffs; Bitcoin At Record  eFXdata

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  • Disappointing derby-day defeat leaves quarter-final hopes in the balance

    Disappointing derby-day defeat leaves quarter-final hopes in the balance

    Worcestershire Rapids succumbed to a 23-run defeat to rivals the Bears on Friday, as their Vitality T20 Blast qualification hopes took a hit.

    The Rapids bowlers took wickets at regular intervals but struggled to contain the Bears batters, as Tom Taylor (1-27) had the most economical evening for his side, accompanied well by Ben Dwarshuis (3-30) as the Bears were bowled out for 176.

    Adam Hose batted in stylish fashion for his 51, but a lack of partnerships made life difficult for the home side, with cameos from Roderick (30) and Isaac (25) saw the home side fall to a 23- run defeat.

    A win against Leicestershire Foxes on Sunday is now essential if the Rapids are to stand a chance of reaching the last-eight of the competition.

    Less than 24 hours on from their nail-biting 12-run win away at Derbyshire Falcons, the Rapids were back in action as captain Brett D’Oliveira announced one team change at the toss, with Henry Cullen coming in for Kashif Ali.

    Electing to bowl first in the searing heat, the Rapids had youngster Henry Cullen to thank for a stunning reflex catch at first-slip in the third over of the match, that rewarded Tom Taylor’s excellent start as Tom Latham departed for one.

    Ben Dwarshuis (3-30) nearly made a breakthrough with the second ball of his spell, but D’Oliveira was unable to cling on to a tough chance at extra-cover, but the very next ball he did strike, as he had Alex Davies caught behind to peg the visitors back once more.

    At the end of the powerplay the Bears made their way to 53-2, with Adam Finch and Khurram Shahzad both introduced into the attack, continuing the Rapid’s search for top-order wickets.

    Hain and Mousley came together, adding 63 for the third-wicket in an assured partnership, before Finch returned in style to remove the dangerous Mousley for 31 in the tenth over.

    Fateh Singh (1-34) produced yet again for his side as he had England hopeful Jacob Bethell caught for six at long-off by Dwarshuis, with the visitors 98-4.

    Sam Hain continued to make life hard for the Rapids, but lost partner Ed Barnard (23) when he top-edged a short ball from Dwarshuis to give Gareth Roderick a steepling catch behind the stumps, before Hain himself departed for 44 when his efforts to clear the rope off Shahzad fell short and straight into the obliging hands of Cullen at deep backward square leg.

    At 141-6 with five overs remaining, Shahzad proved his worth once more by picking up his second wicket of the evening to dismiss Hasan Ali with a smart caught and bowled, before Dwarshuis had Briggs caught behind and Craig Miles was run-out without facing as the Rapids raced towards a strong finish.

    George Garton’s cameo of 36 dragged the Bears to 176 all out, as the Rapids set about their chase.

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  • ‘Superman’ Lands in Hollywood, ‘Dexter: Resurrection’ Arrives and This Week’s Best Events – The Hollywood Reporter

    ‘Superman’ Lands in Hollywood, ‘Dexter: Resurrection’ Arrives and This Week’s Best Events – The Hollywood Reporter

    1. ‘Superman’ Lands in Hollywood, ‘Dexter: Resurrection’ Arrives and This Week’s Best Events  The Hollywood Reporter
    2. How Will Reeve honored his dad at ‘Superman’ premiere  ABC News – Breaking News, Latest News and Videos
    3. Rachel Brosnahan Lights Up the Night in Rahul Mishra  Red Carpet Fashion Awards
    4. 5 Times David Corenswet Stepped Out Looking Like Clark Kent  L’Officiel Philippines
    5. After Receiving Brutal Reviews, New ‘Superman’ Movie Premieres In L.A.  IMDb

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  • Everything we know about ‘Superman’ star David Corenswet’s Jewish identity – Unpacked

    1. Everything we know about ‘Superman’ star David Corenswet’s Jewish identity  Unpacked
    2. From Superman to Phoenix: 7 Superheroes Who Remind Us of Jesus  relevantmagazine.com
    3. Superman and the secular longing for a Savior  Deseret News
    4. Heavenly Heroes: The Surprising Revival Of Superman And Faith  Religion Unplugged
    5. What Makes the New ‘Superman’ Movie So Jewish?  Hey Alma

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  • Julien Alfred back atop podium with statement win in women’s 100m

    Julien Alfred back atop podium with statement win in women’s 100m

    What comes next for Julien Alfred? “The goal is the double”

    The 2025 World Athletics Championships are just two months out (13-21 September) in Tokyo. Alfred is next set to compete at next weekend’s (19 July) London Diamond League, but only in the 200m.

    The goal for Tokyo remains two-fold – literally: She’s aiming to race in both the 100 and 200m.

    “I don’t have any [national] trials, so right now I just have the London 200m,” she said about her plans moving forward. “It’s up to my coach to decide if I run more before Tokyo.”

    Is she shying away from that goal as the season unfolds?

    “The goal is to run a double for sure,” she replied. “But we are taking it one step at a time and one race at a time, really.”

    Alfred claimed her stunning 100m Olympic gold last year at Paris 2024, but then followed that up with a silver medal in the 200m behind American Gabby Thomas. The American sprinters – including Jefferson-Wooden, Sears, Thomas and Sha’Carri Richardson – will all have to go through their national trials, set for early August in Eugene.

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