Qaasid News

Download Our App

Author: admin

  • 41 Microsoft Zero-Day Warnings — Millions Of Users Face Update Choice – Forbes

    1. 41 Microsoft Zero-Day Warnings — Millions Of Users Face Update Choice  Forbes
    2. Windows PowerShell now warns when running Invoke-WebRequest scripts  BleepingComputer
    3. Microsoft Issues Security Fixes for 56 Flaws, Including Active Exploit and Two…

    Continue Reading

  • Times have changed — but the Rockettes keep kicking – NPR

    Times have changed — but the Rockettes keep kicking – NPR

    1. Times have changed — but the Rockettes keep kicking  NPR
    2. 12 things you never knew about the Radio City Rockettes  6sqft
    3. Mother Cabrini Residents Celebrate Rockettes’ Centennial at Radio City Music Hall  The Good Newsroom
    4. What It Takes to Dance a…

    Continue Reading

  • Rapper Jeezy celebrates 20 years of ‘Thug Motivation 101’ with a 101-piece backing orchestra : NPR

    Rapper Jeezy celebrates 20 years of ‘Thug Motivation 101’ with a 101-piece backing orchestra : NPR



    (SOUNDBITE OF SONG, “AND THEN WHAT”)

    JEEZY: (Singing) Let’s get it. First, I’m gone stack my flo’. And then what? Then I’m gone stack some mo’. And then what?

    AYESHA RASCOE, HOST:

    Twenty years ago, rapper Young Jeezy…

    Continue Reading

  • Punjab Sahulat Bazar Authority earns Int’l certifications – RADIO PAKISTAN

    1. Punjab Sahulat Bazar Authority earns Int’l certifications  RADIO PAKISTAN
    2. Punjab Sahulat Bazaars Authority receives international certifications  Profit by Pakistan Today
    3. Punjab CM expresses happiness: Bazaar Authority to get ISO 901 & ISO 27001…

    Continue Reading

  • Vitexin induces apoptosis and enhances daunorubicin efficacy in acute leukemia via modulation of the HIF-1α/Bcl-2/caspase-3 pathway

  • Arber, D. A. et al. International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic clinical and genomic data. Blood 140(11), 1200–1228 (2022).

    Google Scholar 

  • Chennamadhavuni, A., Iyengar, V., Mukkamalla, S. K. R. & Shimanovsky, A. Leukemia. StatPearls. Treasure Island (FL): StatPearls Publishing, Copyright © 2024 (StatPearls Publishing LLC, 2025).

  • Churpek, J. E. Familial myelodysplastic syndrome/acute myeloid leukemia. Best Pract. Res. Clin. Haematol. 30(4), 287–289 (2017).

    Google Scholar 

  • Arbuckle, C. Exploring the use of alternative diets in people living with cancer. Nurs. Stand. 38(3), 63–68 (2023).

    Google Scholar 

  • Harris, P. E., Cooper, K. L., Relton, C. & Thomas, K. J. Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update. Int. J. Clin. Pract. 66(10), 924–939 (2012).

    Google Scholar 

  • Matriz, J., Hamachi, A. & Fukui, J. A. The use of complementary and alternative medicine (CAM) among patients with cancer in Hawaii. J. Clin. Oncol. 42(16_suppl), e24070–e (2024).

    Google Scholar 

  • Posadzki, P., Watson, L. K., Alotaibi, A. & Ernst, E. Prevalence of use of complementary and alternative medicine (CAM) by patients/consumers in the UK: systematic review of surveys. Clin. Med. (Lond). 13(2), 126–131 (2013).

    Google Scholar 

  • Yousefi, M., Reihani, H., Heydari, M., Nasimi Doost Azgomi, R. & Hashempur, M. H. Complementary and alternative medicine use among cancer patients in Iran: A systematic review. Prev. Med. Rep. 39, 102644 (2024).

    Google Scholar 

  • Ketelut-Carneiro, N. & Fitzgerald, K. A. Apoptosis, pyroptosis, and necroptosis-oh my! The many ways a cell can die. J. Mol. Biol. 434(4), 167378 (2022).

    Google Scholar 

  • Elmore, S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35(4), 495–516 (2007).

    Google Scholar 

  • Shen, S., Shao, Y. & Li, C. Different types of cell death and their shift in shaping disease. Cell. Death Discov. 9(1), 284 (2023).

    Google Scholar 

  • Alberts, B. J. A. et al. Programmed Cell Death (Apoptosis). 4th edition ed: Molecular Biology of the Cell. (2002).

  • Booth, L. A., Tavallai, S., Hamed, H. A., Cruickshanks, N. & Dent, P. The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell. Signal. 26(3), 549–555 (2014).

    Google Scholar 

  • Karmakar, U. et al. Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions. Cell. Death Dis. 12(4), 296 (2021).

    Google Scholar 

  • Tait, S. W. & Green, D. R. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell. Biol. 11(9), 621–632 (2010).

    Google Scholar 

  • Yutharaksanukul, P. et al. Effects of purified vitexin and iso-vitexin from mung bean seed coat on antihyperglycemic activity and gut microbiota in overweight individuals’ modulation. Nutrients. 16(17) (2024).

  • Maneewan, S., Tangpromphan, P. & Jaree, A. Separation of vitexin and Iso-vitexin from mung bean seed coats using a three-zone simulated moving bed (SMB). Waste Biomass Valoriz. 12(12), 6601–6618 (2021).

    Google Scholar 

  • Liu, X., Jiang, Q., Liu, H. & Luo, S. Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells. Biol. Res. 52(1), 7 (2019).

    Google Scholar 

  • Najafipour, R., Momeni, A. M., Mirmazloomi, Y. & Moghbelinejad, S. Vitexin induces apoptosis in MCF-7 breast cancer cells through the regulation of specific MiRNAs expression. Int. J. Mol. Cell. Med. 11(3), 197–206 (2022).

    Google Scholar 

  • Bhardwaj, M. et al. Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. Oncotarget 9(3), 3278–3291 (2018).

    Google Scholar 

  • Zhou, P. et al. Vitexin inhibits gastric cancer growth and metastasis through HMGB1-mediated inactivation of the PI3K/AKT/mTOR/HIF-1alpha signaling pathway. J. Gastric Cancer. 21(4), 439–456 (2021).

    Google Scholar 

  • Mubeen, M., Ali, H., Zehra, S. S. & Khan, A. Harnessing the power of vitexin as a vitamin D receptor agonist in colorectal cancer: A new frontier. Balkan Med. J. 42(3), 276–278 (2025).

    Google Scholar 

  • Khoja, K. K. et al. Cytotoxicity of fenugreek sprout and seed extracts and their bioactive constituents on MCF-7 breast cancer cells. Nutrients. 14(4) (2022).

  • Ganesan, K. & Xu, B. Molecular targets of vitexin and isovitexin in cancer therapy: a critical review. Ann. N Y Acad. Sci. 1401(1), 102–113 (2017).

    Google Scholar 

  • Sarkar, M. K., Mahapatra, S. K. & Vadivel, V. Oxidative stress mediated cytotoxicity in leukemia cells induced by active phyto-constituents isolated from traditional herbal drugs of West Bengal. J. Ethnopharmacol. 251, 112527 (2020).

    Google Scholar 

  • Sarkar, M. K., Kar, A., Jayaraman, A., Kar Mahapatra, S. & Vadivel, V. Vitexin isolated from prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via Inhibition of the BCR-ABL-Ras-Raf pathway. J. Pharm. Pharmacol. 74(1), 103–111 (2022).

    Google Scholar 

  • Liang, C., Jiang, Y. & Sun, L. Vitexin suppresses the proliferation, angiogenesis and stemness of endometrial cancer through the PI3K/AKT pathway. Pharm. Biol. 61(1), 581–589 (2023).

    Google Scholar 

  • Zhou, Y. et al. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin. Cancer Res. 15(16), 5161–5169 (2009).

    Google Scholar 

  • Al-Aamri, H. M. et al. Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia. BMC Cancer. 19(1), 179 (2019).

    Google Scholar 

  • Kantarjian, H. M., Kadia, T. M., DiNardo, C. D., Welch, M. A. & Ravandi, F. Acute myeloid leukemia: treatment and research outlook for 2021 and the MD Anderson approach. Cancer 127(8), 1186–1207 (2021).

    Google Scholar 

  • Rowe, J. M. The 7 + 3 regimen in acute myeloid leukemia. Haematologica 107(1), 3 (2022).

    Google Scholar 

  • Sarkar, M. K., Vadivel, V., Raja, M. R. C. & Kar Mahapatra, S. Investigation of phytochemical constituents of anti-leukemic herbal drugs used by the traditional healers of Purulia, Birbhum and Bankura districts of West Bengal. Nat. Prod. Res. 34(23), 3388–3393 (2020).

    Google Scholar 

  • Ullah, A. et al. Important flavonoids and their role as a therapeutic agent. Molecules 25(22), 5243 (2020).

    Google Scholar 

  • Chou, T. C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 70(2), 440–446 (2010).

    Google Scholar 

Continue Reading

  • How Social Media Shapes Children’s Attention Over Time

    How Social Media Shapes Children’s Attention Over Time

    NEW research from a major USA child-development study suggests that daily social media use, though often dismissed as harmless, may contribute to small but measurable increases in inattention symptoms over time. The findings, drawn from more…

    Continue Reading

  • Nanit Home Display Review: A Transformative Tablet

    Nanit Home Display Review: A Transformative Tablet

    Photograph: Nicole Kinning

    The Home monitor can run wirelessly and charges via a USB-C cable. It relies on your Wi-Fi network to connect to the camera, so while you can carry the monitor around your home, you can’t take it fully “off-grid”…

    Continue Reading

  • ICYMI: Highlights From AACR 2025

    ICYMI: Highlights From AACR 2025

    Each year, certain developments in oncology rise above the rest—either for their clinical impact, their potential to shift standards of care, or simply because they capture the imagination of clinicians, researchers, and patients alike. In 2025, readers gravitated toward stories spanning cutting-edge immunotherapy, emerging targets like RAS, lifestyle-related cancer risks, and promising early-phase science presented at the American Association for Cancer Research (AACR) meeting.

    Here are the 5 most-viewed AACR pieces of 2025.

    5. Proving the Concept: A Sampler of Early-Stage Science at AACR 2025

    Among the standout developments were SENTI-202, an off-the-shelf chimeric antigen receptor natural killer–cell therapy that produced complete remissions in a subset of patients with relapsed or refractory acute myeloid leukemia, and CHS-114, a novel antibody targeting CCR8-positive regulatory T cells with the potential to reprogram the tumor microenvironment in head-and-neck cancers. The roundup also featured encouraging data on micvotabart pelidotin, an antibody–drug conjugate that targets the EDB+ fibronectin domain to disrupt tumor structure across several solid tumors. Collectively, these early signals offer more than incremental progress. they represent concept-proving science with the potential to redefine treatment approaches in the years ahead.

    Read the full article.

    4. From “Super-Skeptical” Beginnings, a New Immune-Modulatory Vaccine Awaits Phase 3 Results

    This piece explored the development of an immunomodulatory vaccine designed not to prevent disease but to reshape immune responses against existing conditions—a departure from traditional vaccine use. Its move toward phase 3 trials speaks to the broader shift in oncology to harnessing and recalibrating the immune system in increasingly sophisticated ways. The article tracked how therapeutic vaccines might complement or even enhance established modalities like checkpoint blockade and adoptive cell therapy. With a pivotal trial now underway, many are waiting to see whether the early promise can translate into durable, clinically meaningful benefit.

    Read the full article.

    3. Addressing KRAS Resistance: RAS(ON) Therapies Find Limelight at AACR

    The long-standing challenge of targeting KRAS—once considered undruggable—remains a focal point of oncology research. The AACR 2025 updates on “RAS-(ON)” inhibitors, which aim to neutralize active forms of the protein driving tumor growth, struck a chord with oncologists who routinely confront KRAS-mutant cancers in the clinic. As RAS-targeting strategies expand and mature, the article highlighted a path toward more effective options for patients with KRAS-driven lung, colorectal, pancreatic, and other malignancies.

    Read the full article.

    2. Ultraprocessed Foods Tied to Higher Cancer Risk

    This interview spotlighted new epidemiologic findings linking high consumption of ultraprocessed foods with an elevated risk of developing cancer, drawing in clinicians, researchers, and consumers interested in the intersection of diet and cancer prevention. The analysis presented by Mingyang Song, MBBS, ScD, Harvard T.H. Chan School of Public Health, emphasized that although the overall association is statistically modest, the relationship appears consistent—particularly for colorectal cancer among men. This interview reflects rising awareness of lifestyle factors in cancer risk, as well as an appetite for clearer guidance on how diet contributes to long-term health outcomes.

    Watch the full interview.

    1. Patients With Multiple Types of Mismatch Repair–Deficient Tumors Avoid Surgery With Dostarlimab

    This year’s most-read story detailed a landmark phase 2 trial showing that patients with mismatch repair–deficient (dMMR) solid tumors achieved high rates of complete clinical response with dostarlimab, allowing many to forgo surgery entirely. The findings—82% complete response among evaluable patients and 92% recurrence-free survival at 2 years—captivated readers because they signal a potential paradigm shift in how dMMR tumors are managed across gastrointestinal and urothelial cancers. As early-onset gastrointestinal cancers continue to rise, the article highlighted a future in which immunotherapy-first strategies may offer curative outcomes without the morbidity of traditional operative approaches.

    Read the full article.

    Continue Reading

  • Little Foot hominin fossil may be new species of human ancestor | Evolution

    Little Foot hominin fossil may be new species of human ancestor | Evolution

    Little Foot, one of the world’s most complete hominin fossils, may be a new species of human ancestor, according to research that raises questions about our evolutionary past.

    Publicly unveiled in 2017, Little Foot is the most complete…

    Continue Reading

  • Bluey’s Quest for the Gold Pen: after some misfires we finally have the first good Bluey video game | Games

    Bluey’s Quest for the Gold Pen: after some misfires we finally have the first good Bluey video game | Games

    Bluey embodies the talent, heart and character of Australia’s creative industries. But unfortunately, until now, the beloved franchise’s video games had a track record spottier than her friend Chloe the dalmatian.

    Some parents treated Budge…

    Continue Reading