Aston Villa commenced the second week of pre-season training at Bodymoor Heath on Monday, as more of Unai Emery’s first team stars returned to action. Preparations for 2025/26 got underway last week, with a number of Villans back in the building for the first time in six weeks, as many players who spent the summer break on international duty returned a week later. The likes of Ollie Watkins, Lucas Digne, Youri Tielemans and captain John McGinn set foot in Bodymoor and got back to work, as Emery prepares his men for their first friendly outing at Walsall this Wednesday (ko 7.30pm). Here’s how the day unfolded… Checking in The Villans touched down at Bodymoor bright and early and got straight to work, with Emery’s charges all smiles in the July sunshine… Getting started in the gym First off was an indoor session in the gym for the Villans, who were put through their paces before heading outside… Grinding on the grass Then came an intense session outside for those back in training, as the Villans worked up a sweat by getting their legs moving on the grass… Villa’s all-new training range, as sported by Emery’s men above, is also now available to shop – both online and in person, from the Villa Store and AVFC Sport and Leisure store in the Bullring. 2025/26 Training Range On sale now Shop Here
Author: admin
-
FDA’s Oncologic Drugs Advisory Committee Casts Interesting Votes
John M. Burke, MD
Hematologist and Medical Oncologist Rocky Mountain Cancer Centers Associate Chair US Oncology Hematology Research Program
Aurora, CO
On May 20, 2025, the FDA convened a meeting of the Oncologic Drugs Advisory Committee (ODAC) to consider 2 important questions. The first addressed the application for full approval of glofitamab-gxbm (Columvi) for patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL). The second addressed the application for the monoclonal antibody daratumumab (Darzalex) for adult patients with high-risk smoldering myeloma (SM). The FDA granted accelerated approval in 2023 to glofitamab for treatment of R/R DLBCL based on a single-arm trial that demonstrated an overall response rate of 56%. STARGLO (NCT04408638) was the confirmatory trial that, if positive, would lead to a full approval of glofitamab. In the phase 3 STARGLO trial, patients with R/R DLBCL were assigned to receive glofitamab plus gemcitabine and oxaliplatin (GemOx) or rituximab (Rituxan; Genentech) plus GemOx. The results favored glofitamab-GemOx, which demonstrated improved overall survival (OS), progression-free survival (PFS), complete response rates, and overall response rate. Although these results suggest glofitamab should be a slam dunk for full FDA approval, there is, of course, a rub. The rub is that only 25 of the 274 patients in STARGLO were from North America, whereas 131 patients, or 48%, were from Asia. Furthermore, on subset analysis, the North American patients did not benefit from glofitamab-GemOx. The FDA convened the ODAC meeting to answer the question of whether the STARGLO population and trial results are applicable to the proposed US patient population. The ODAC voted 8-to-1 that the answer is no. The FDA’s message is loud and clear: A drug may not get approved if the trial does not include enough patients from the US. Pharma, take note. T he second question addressed by ODAC was more straightforward: “Should we approve this drug?” They considered whether the results of the phase 3 AQUILA (NCT03301220) trial support a favorable benefit-risk profile for daratumumab in high-risk SM. Patients treated with daratumumab had improved PFS and OS; however, OS results were immature. The ODAC voted 6-to-2 in favor of daratumumab’s benefit/risk profile in SM. I find this a bit surprising. What really matters clinically is whether such a treatment can prevent morbidity and/or prolong OS. It will be interesting to see what the FDA decides—and what our patients prefer.
Continue Reading
-
Scientists find Uranus is surprisingly warm, heating up the case for a new planetary mission
Scientists have found that Uranus is emitting its own internal heat — even more than it receives from sunlight — and this discovery contradicts observations of the distant gas giant made by NASA’s Voyager 2 probe nearly four decades ago.
Scientists led by Xinyue Yang of the University of Houston analyzed decades of readings from spacecraft and computer models to find that Uranus emits 12.5% more internal heat than the amount of heat it receives from the sun. However, that amount is still far less than the internal heat of other outer solar system planets like Jupiter, Saturn and Neptune, which emit 100% more heat than they get from the sun.
The researchers behind this new study say Uranus’ internal heat could help reveal the origins of the curious, tilted world. “This means it’s still slowly losing leftover heat from its early history, a key piece of the puzzle that helps us understand its origins and how it has changed over time,” Wang said in a statement.
In 1986, the iconic Voyager 2 probe flew by Uranus while headed out of the solar system and into interstellar space. A good deal of what scientists understand about the seventh planet from the sun comes from that flyby, that found that Uranus does not reveal significant internal heat.
But it turns out that we may have caught Uranus at a weird time, and some of the readings Voyager 2 collected could have been skewed by a surge in solar weather that occurred during its flyby of the planet.
By reviewing a large set of archival data and combining that with computer models, researchers now believe the internal heat emitted by Uranus could imply a completely different internal structure or evolutionary history for the planet we thought we knew. Its believed that Uranus formed around 4.5 billion years ago along with the rest of the solar system, and NASA believes it formed closer to the sun before moving to the outer solar system around 0.5 billion years later. That story, however, is now called into question by these new findings.
“From a scientific perspective, this study helps us better understand Uranus and other giant planets,” Wang said in the statement. The researchers also believe this new understanding of Uranus’ internal processes could help NASA and other agencies plan for missions to the distant planet.
In 2022, the National Academy of Sciences flagged a mission concept known notionally as Uranus Orbiter and Probe (UOP) as one of the highest-priority planetary science missions for the next decade. But even then, before massive budget uncertainty hit NASA and the science community in the wake of President Donald Trump’s overhaul of U.S. government spending, scientists knew such an ambitious and expensive mission would be difficult to put into motion.
“There are many hurdles to come — political, financial, technical — so we’re under no illusion,” Leigh Fletcher, a planetary scientist at the University of Leicester in the U.K. who participated in the decadal survey process, told Space.com in 2022 when the report was published. “We have about a decade to go from a paper mission to hardware in a launch fairing. There’s no time to lose.”
A full-sized wide shot of Uranus captured by the James Webb Space Telescope on Feb. 6, 2023 also shows six of the planet’s known 27 moons. (Image credit: NASA, ESA, CSA, STScI, J. DePasquale (STScI)) Whether or not new research into Uranus helps boost support for such a mission, scientists are already hailing these new results as groundbreaking on their own. Study co-author Liming Li said the study of Uranus’ internal heat not only helps us understand the distant, icy world better, but could also help inform studies of similar processes here on Earth, including our own changing climate.
“By uncovering how Uranus stores and loses heat, we gain valuable insights into the fundamental processes that shape planetary atmospheres, weather systems and climate systems,” Li said in the statement. “These findings help broaden our perspective on Earth’s atmospheric system and the challenges of climate change.”
A study on Uranus’ internal heat was published in the journal Geophysical Research Letters.
Continue Reading
-
Int’l AIDS forum kicks off in Rwanda’s capital-Xinhua
KIGALI, July 14 (Xinhua) — The 13th International AIDS Society (IAS) Conference on HIV Science officially opened Monday in the Rwandan capital of Kigali, with a strong call to accelerate access to long-acting HIV prevention and treatment innovations amid growing global funding challenges.
The event, themed “Breakthroughs amid Crisis: the Future of HIV Innovation,” has convened about 4,000 participants, including global leaders, researchers, scientists, and civil society members.
Speaking at the conference, Rwandan Minister of Health Sabin Nsanzimana said that Rwanda’s experience in the HIV response over the past few decades demonstrates what is possible when countries prioritize people-centered approaches and invest in strategic partnerships.
“We have better tools for prevention and treatment. We have better ways to engage our communities to fight stigma and discrimination, and better integration within our systems. This means we can not only achieve HIV control, but we also need to strengthen our health systems,” he added.
IAS President Beatriz Grinsztein underlined new World Health Organization (WHO) guidelines, groundbreaking licensing agreements, and promising research as signs that long-acting HIV prevention and treatment options are becoming more feasible for widespread use.
“Our next challenge is clear: leaders must commit the funding and resources needed to integrate these scientific advances into health systems quickly and equitably so that people everywhere can benefit from these life-changing options,” Grinsztejn emphasized.
At the event, the WHO issued a statement announcing new guidelines that recommend using injectable lenacapavir twice a year as an additional pre-exposure prophylaxis option for HIV prevention — a landmark policy action that could help reshape the global HIV response.
“While an HIV vaccine remains elusive, lenacapavir is the next best thing: a long-acting antiretroviral shown in trials to prevent almost all HIV infections among those at risk,” WHO Director-General Tedros Adhanom Ghebreyesus is quoted as saying in the statement.
The IAS Conference on HIV Science is recognized as the world’s most influential meeting on HIV research and its applications.
Its 2025 edition, which runs until Thursday, features hundreds of sessions and presentations focused on translating scientific breakthroughs into real-world impact, with a particular emphasis on solutions for regions and populations most affected by HIV. ■
Continue Reading
-
Volvo Cars to book $1.2bn charge on tariffs and launch delays
Unlock the Editor’s Digest for free
Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter.
Volvo Cars will book a one-off charge of SKr11.4bn ($1.2bn) as the Swedish group forecast smaller profits from two critical vehicle models due to US President Donald Trump’s car tariffs and launch delays.
The Geely-owned group is heavily exposed to higher import tariffs in the US and Europe and has already announced a cut of 3,000 jobs globally to save costs.
Volvo Cars on Monday blamed the non-cash impairment charge on launch delays and additional development costs for its flagship EX90 sport utility vehicle, which led to lower margins.
The company added it was unable to sell its new ES90 — which is built in China — profitably in the US due to the 25 per cent tariffs Trump has imposed on imports of foreign-made vehicles.
The group has said it wants to increase production in South Carolina to address the higher US tariffs.
German carmakers and Volvo Cars had earlier expressed hope that the US would adjust its policy to allow them to offset import tariffs if they also exported vehicles from America. But there has been no such concession from the Trump administration, which over the weekend threatened to impose tariffs of 30 per cent on the EU from August 1.
“Given market developments such as import tariffs in the US, development and launch delays for the EX90 and strategic investment prioritisations, we have reassessed volume assumptions for these two cars,” said Fredrik Hansson, chief financial officer at Volvo Cars. This has led to “lower than planned lifecycle profitability”, he added.
To address the EU’s higher tariffs on imports of electric vehicles made in China, Volvo Cars will produce its EX30 EV model in its Ghent plant in Belgium, as well as in China from this year.
Beyond the tariffs, the carmaker was also forced to temporarily pause production at its Charleston, South Carolina, plant in May due to a supplier issue, while the company has suffered from a slower than expected production boost for the EX90 due to software issues.
Bernstein analyst Stephen Reitman said the group’s second-quarter results, which will be released on Thursday, would probably be the weakest for the company for 2025, with gross margins likely to fall to 16 per cent from 18 per cent in the previous quarter.
“Volvo will feel the full effect of EU-China and EU-US tariffs before mitigations start to kick in from third quarter,” he added.
Shares in Volvo Cars fell 4.4 per cent on Monday following Trump’s tariff threat on the EU, bringing its year-to-date decline to 25 per cent.
Continue Reading
-
Threads users still barely click links
Two years in, Threads is starting to look more and more like the most viable challenger to X. It passed 350 million monthly users earlier this year and Mark Zuckerberg has predicted it could be Meta’s next billion-user app.
But Threads still isn’t sending much traffic to other websites, which could make the platform less appealing for creators, publishers and others whose businesses depend on non-Meta owned websites. According to Similarweb, a marketing intelligence firm, outbound referral traffic from Threads climbed to 28.4 million visits in June. That’s a notable jump from 15.1 million visits a year ago, but still relatively tiny considering Threads is currently averaging more than 115 million users a day on its app, according to Similarweb.
Regular Threads users have long suspected that Meta deprioritizes posts with links. For most of the last two years of Threads’ existence the common wisdom was that users shouldn’t share links, or should only share them as replies to a primary post. Instagram chief Adam Mosseri, who also oversees Threads, hasn’t exactly encouraged linking either. He said last year that Threads doesn’t intentionally downrank links but that “we don’t place much value on” them because “people don’t like and comment on links much.”
Meta’s reluctance wasn’t just about users’ preferences, though. The company was also concerned about how spammers and other bad actors might abuse links on the text-based platform. More recently though, Meta has changed course, and has been taking steps to surface more “good” links in recommended posts.
“We’ve been working on making sure links are ranked properly,” Mosseri said in June. “Links have been working much better for more than a month now.” The company has also bolstered links on the platform by allowing users to add more links to their Threads profiles and providing link-specific analytics to its “insights” feature. “We want Threads to be a place that helps you grow your reach – even outside of Threads,” Meta said in a May update.
But despite these changes, Threads is still sending very little traffic to websites. Data shared by Similarweb shows that during May and June of last year — when Threads had more than 150 million monthly users — it sent just 24.8 million referrals to outside websites. During May and June of this year, that number more than doubled, rising to 51.8 million.
Those numbers still suggest, though, that the majority of Threads’ users are rarely, if ever, clicking on links they see on Threads. Lia Haberman, a social media marketing consultant and author of the ICYMI newsletter, said she’s not surprised. “People just got trained not to look for them, not to include them, not to think about them,” she tells Engadget. “You can’t just flip a switch and all of a sudden expect people to embrace links.”
Publishers, a group that likely posts more links on Threads than anyone else, don’t seem to be seeing significant traffic from Threads either. Data provided by Chartbeat, a company that provides analytics data to publishers, shows that publisher page views from Threads have nearly doubled since the start of the year, rising from 8.8 million in January to 15.1 million in June.
Interestingly, according to both Similarweb and Chartbeat’s data for 2025, referrals from Threads peaked in March. That month, Threads sent 28.8 million outbound referrals to websites, according to Similarweb, while Chartbeat publishers saw 25 million page views from the platform.
But while the latest stats show that traffic from Threads has grown significantly over the last year, it still represents a tiny proportion of the publishers’ traffic overall. According to Chartbeat, over the last year and a half Threads has consistently accounted for less than one tenth of a percent of sites’ referral traffic. By comparison, Facebook referrals have hovered around 2 – 3 percent over the same period, while Google Discover has accounted for about 13 – 14 percent of referrals. Even among other “small” sources of referrals, like chatGPT, Reddit and Perplexity, Threads is only ahead of Perplexity in terms of the number of referrals it sends.
Threads referrals even pale in comparison to Twitter’s, which was never known as a major traffic driver even before Elon Musk’s takeover of the company. In January of 2018, Twitter accounted for 3 percent of publishers’ page views, according to Chartbeat data reported by the Press Gazette. By April of 2023, after Musk’s takeover but before he rebranded the site to X, that number had fallen to 1.2 percent.
Chartbeat’s data isn’t a complete picture — stats provided to Engadget were based on an analysis of 3,000 sites that have opted in to anonymized data sharing — but the slight increase in referral traffic roughly lines up with another major change Meta made this year. In January, following Mark Zuckerberg’s move to end fact checking and walk back content moderation rules, Threads also ended its moratorium on recommending political content to all users.
Following this change, some publishers of political news, including Newsweek, Politico and Forbes saw a spike in referrals from Threads, Digiday reported. But those gains don’t seem to be universal, and it’s not clear why some publishers may be benefitting more than others. “Threads is trailing significantly in traffic, subscription conversions, and overall conversion rate,” compared with Bluesky and X, the Boston Globe’s VP of Platforms Mark Karolian recently shared on Threads.
While Threads’ growth so far hasn’t been hampered by its inability to drive users off-platform, it could become an increasingly important issue for Meta if it really wants to bring more creators onto the platform. The company is also getting ready to flip the switch on ads on the platform. A user base that ignores links could complicate Meta’s pitch to advertisers, who are already taking a cautious approach to Threads. Meta declined to comment.
Haberman says that Threads’ ambivalence toward links might be symptomatic of a larger identity crisis the platform is still facing. It has a large user base, but it’s not always clear who Threads is really for. It isn’t known as a destination to follow breaking news, like Twitter once was, or as a place with highly-engaged subcultures, she notes. “Threads needs to have a purpose,” she says. “And right now, it seems very much like a suggestion box at work where people are just filing complaints and trauma dumping.”
Whether smaller platforms like Threads can reliably drive traffic to websites is an increasingly urgent question. At a time when online search feels like it’s getting worse, AI is rapidly replacing many searches and cannibalizing websites’ search traffic. Publishers, as The Wall Street Journal recently reported, are being hit especially hard by these shifts.
Threads is extremely unlikely to fill those gaps on its own, even if referral traffic vastly improves. And publishers in particular have plenty of reasons not to become too reliant on a Meta-owned platform. At the same time, there’s clearly an opportunity for Threads to play a bigger role in a post-search world. That would not only benefit the creators, publishers and small business owners Meta has long courted, it could help Threads establish an identity of its own.
Have a tip for Karissa? You can reach her by email, on X, Bluesky, Threads, or send a message to @karissabe.51 to chat confidentially on Signal.
Continue Reading
-
Anthropic’s Claude chatbot can now make and edit your Canva designs
Canva users can now create, edit, and manage their designs by describing their requirements to Anthropic’s Claude AI. The connection is the latest of several integrations that allow Claude users to access third-party tools and services, including Figma, Notion, Stripe, and Prisma, without having to leave their conversation with the AI chatbot.
Starting today, Claude users will be able to use natural language prompts to complete design tasks in their linked Canva account, such as creating presentations, resizing images, and automatically filling premade templates. The integration also enables users to search for keywords within Canva Docs, Presentations, and brand templates, and summarize them through the Claude AI interface. The feature requires both a paid Canva account (which starts at $15 per month) and a paid Claude account ($17 per month).
Anthropic is utilizing the Model Context Protocol (MCP) server that Canva launched last month, which provides Claude with secure access to user Canva content. MCP, often referred to as the “USB-C port of AI” apps, is an open-source standard that enables developers to quickly connect their AI models with other apps and services. Companies like Anthropic, Microsoft, Figma, and Canva have embraced MCP to prepare their platforms for a future tech landscape that’s expected to be filled with AI agents.
“Instead of uploading or manually transferring ideas, users can now generate, summarize, review, and publish Canva designs, all within a Claude chat,” Canva Ecosystem head Anwar Haneef said in a statement to The Verge. “MCP makes this possible with a simple toggle in settings, marking a powerful shift toward user-friendly, AI-first workflows that combine creativity and productivity in one.”
Claude is the first AI assistant to support Canva design workflows through MCP, but the chatbot has other design platform offerings thanks to a similar partnership with Figma that was announced last month. A new Claude integrations directory is also launching on web and desktop today, which should give users an easy overview of all the tools and connected apps at their disposal.
Continue Reading
-
Anthropic’s AI agent can now automate Canva, Asana, Figma and more – here’s how it works
CFOTO / Contributor/Getty Claude just gained a little more autonomy.
Anthropic, the AI start-up behind Claude, announced Monday that the system can now directly interact with and pull information from a directory of third-party apps and websites, including Stripe, Figma, Prisma, Canva, Asana, and others. The idea is to save users time that would ordinarily be spent transferring information from Claude’s outputs into one of those external services, and vice versa.
Also: Claude might be my new favorite AI tool for Android – here’s why
“Now Claude can have access to the same tools, data, and context that you do — transforming it from a helpful assistant into an informed AI collaborator that gives you more relevant responses and can work with you directly in your tools,” Anthropic wrote in a press release published Monday.
How does it work?
The new directory is populated by “connectors,” or links to various websites and desktop extensions. Think of them as digital gateways through which Claude can access your data and weave it into new assets.
For example, you can now prompt the chatbot to pull your company’s revenue data from Stripe and organize it into an easily digestible quarterly report, rather than having to transfer the data yourself into an AI-generated template. Or if you’re a project manager and need to update your team’s Asana workflow following a team meeting, you can prompt Claude to reference and pull all relevant information from an Apple Notes doc. Similarly, product developers can ask Claude to pull notes from Linear to track a bug-fixing process, and graphic designers can easily prompt Claude to create designs in Canva.
“Claude is quickly becoming an essential creative partner for millions of people, and this integration brings Canva’s full design capabilities directly into that experience,” Anwar Haneef, head of ecosystem at Canva, said in a statement. “Instead of uploading or manually transferring ideas, users can now generate, summarize, review, and publish Canva designs, all within a Claude chat.”
How to access
The new directory for Claude is available now for all web and desktop users. You can visit the directory here and give Claude permission to access your third-party work data by clicking “Connect.”
More capable chatbots
The announcement arrives at a time when tech developers are busily working to broaden the capabilities of chatbots, driven by an industry-wide belief that the future will be filled with AI agents — systems that can go beyond merely providing text responses to user queries by autonomously pulling external information from across the web.
An agentic travel-planning tool, for instance, might be able to book flights, hotels, and restaurants on your behalf, while also interacting with you directly and in natural language to answer all of your travel-related questions.
Also: How agentic AI is transforming the very foundations of business strategy
The push into agents is co-occurring with — and directly fueled by — what’s effectively become a kind of digital real estate competition among AI companies. Chatbots are no longer siloed by website or app; they’re being deployed across an increasingly vast online landscape, connected with a growing number of external apps, as tech giants vie to make their proprietary AI models essentially the default operating systems for the next evolutionary stage of the internet.
ChatGPT’s image-generation feature, to cite just one recent example, can now be accessed on Meta-owned WhatsApp. OpenAI, which owns the chatbot, also reportedly has plans to weave it into a new suite of productivity tools that would rival the likes of Google Workplace and Microsoft Office 365.
Anthropic’s own computer use tool, which debuted in October, allows Claude to interact with the digital tools on a desktop in much the same way that a human user would.
Get the morning’s top stories in your inbox each day with our Tech Today newsletter.
Continue Reading
-
US Congress panel to hold hearing on ‘political repression in Pakistan’
Listen to article The Tom Lantos Human Rights Commission of the US Congress will hold a hearing to examine the ‘ongoing repression of political opposition’ in Pakistan, according to an announcement posted on the Commission’s official website.
The hearing, scheduled to be held in person and streamed online, will focus on actions by the Pakistani government that allegedly restrict political freedoms, including the treatment of opposition political figures, suppression of independent journalism, and controls over media and communication.
Hearing Notice — Pakistan: Ongoing Political Repression
Date: Tuesday, July 15th, 2025
Time: 2:00 – 4:00 PM
Location: Rayburn 2255Details: https://t.co/VpI1m5Wp8c
— Tom Lantos Human Rights Commission (@TLHumanRights) July 9, 2025
The Commission stated that it will assess the implications of these actions for democracy and human rights in Pakistan. It is tasked with promoting, defending, and advocating for international human rights as outlined in the Universal Declaration of Human Rights and other key human rights frameworks.
According to the announcement, many observers trace the current phase of repression to 2022, when then-prime minister Imran Khan was removed from office, later convicted of corruption, and imprisoned.
The US State Department’s 2023 Country Report on Human Rights Practices highlights several human rights concerns in Pakistan, including enforced disappearances, extra-judicial killings, the persecution of religious and ethnic minorities, and transnational repression.
The Commission noted that Pakistan’s general elections in February 2024 were marked by “undue restrictions on freedoms of expression, association, and peaceful assembly,” as well as incidents of electoral violence and interference with fundamental rights, as outlined in a statement by the US State Department.
Witnesses scheduled to testify include Ben Linden of Amnesty International, human rights lawyer Jared Genser, Sadiq Amini of the Afghanistan Impact Network, and Zulfikar Bukhari, an advisor to Imran Khan.
The hearing is open to Members of Congress, staff, the public, and media. It will be streamed live on the Commission’s website and on the House digital channel.
Continue Reading
-
Kate Middleton denied Princess Charlotte’s help at Wimbledon
Kate Middleton asks Charlotte to stop in adorable Wimbledon moment Kate Middleton and Prince William arrived at the final day of Wimbledon along with their children Prince George and Princess Charlotte while their youngest son Prince Louis stayed home.
In the summer heat with the temperature reaching 81 degrees at the start of the match, sitting in the Royal Box at Centre Court, the royals were spotted fanning themselves.
A sweet moment captured by the photograph showed Charlotte fanning her mom.
As reported by People Magazine, the photographer Karwai Tang called the moment “lovely.”
He told the outlet, “It was a lovely interaction.”
When Charlotte briefly fanned Kate, she smiled and asked her daughter to stop after a moment.
It is worth mentioning that Kate Middleton arrived prepared to beat the heat at Wimbledon as she brought a sun hat in hand and donned shades.
While wearing hats is discouraged in the Royal Box as it “tends to obscure the vision of those seated behind them,” there are exceptions in the hot days.
Princess Charlotte and Prince George have made Wimbledon appearances previously with Kate Middleton and Prince William, but their brother Prince Louis is yet to make his debut.
Continue Reading