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  • Stokholm, J. et al. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. Sci. Transl. Med. 12, eaax9929 (2020).

  • Dai, D. L. Y. et al. Breastfeeding enrichment of B. longum subsp. infantis mitigates the effect of antibiotics on the microbiota and childhood asthma risk. Med 4, 92–112.e5 (2023).

    Google Scholar 

  • Boulund, U. et al. Gut microbiome associations with host genotype vary across ethnicities and potentially influence cardiometabolic traits. Cell Host Microbe 30, 1464–1480.e6 (2022).

    Google Scholar 

  • Kurilshikov, A. et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat. Genet. 53, 156–165 (2021).

    Google Scholar 

  • Lehtimäki, J. et al. Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases. J. Allergy Clin. Immunol. 148, 234–243 (2021).

    Google Scholar 

  • Leal Rodríguez, C. et al. The infant gut virome is associated with preschool asthma risk independently of bacteria. Nat. Med. 30, 138–148 (2024).

    Google Scholar 

  • Wood, D. J. Adenovirus gastroenteritis. Br. Med. J. 296, 229–230 (1988).

    Google Scholar 

  • Spandole, S., Cimponeriu, D., Berca, L. M. & Mihăescu, G. Human anelloviruses: an update of molecular, epidemiological and clinical aspects. Arch. Virol. 160, 893–908 (2015).

    Google Scholar 

  • Hino, S. & Miyata, H. Torque teno virus (TTV): current status. Rev. Med. Virol. 17, 45–57 (2007).

    Google Scholar 

  • Miyata, H. et al. Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus. J. Virol. 73, 3582–3586 (1999).

    Google Scholar 

  • Ninomiya, M. et al. Identification and genomic characterization of a novel human torque teno virus of 3.2 kb. J. Gen. Virol. 88, 1939–1944 (2007).

    Google Scholar 

  • Cebriá-Mendoza, M. et al. Deep viral blood metagenomics reveals extensive anellovirus diversity in healthy humans. Sci. Rep. 11, 6921 (2021).

    Google Scholar 

  • Arze, C. A. et al. Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome. Cell Host Microbe 29, 1305–1315.e6 (2021).

    Google Scholar 

  • Ninomiya, M., Takahashi, M., Nishizawa, T., Shimosegawa, T. & Okamoto, H. Development of PCR assays with nested primers specific for differential detection of three human anelloviruses and early acquisition of dual or triple infection during infancy. J. Clin. Microbiol. 46, 507–514 (2008).

    Google Scholar 

  • Virgin, H. W., Wherry, E. J. & Ahmed, R. Redefining chronic viral infection. Cell 138, 30–50 (2009).

    Google Scholar 

  • Osiowy, C. Detection of TT virus in human hair and skin. Hepatol. Res. 16, 155–162 (2000).

    Google Scholar 

  • Inami, T., Konomi, N., Arakawa, Y. & Abe, K. High prevalence of TT virus DNA in human saliva and semen. J. Clin. Microbiol. 38, 2407–2408 (2000).

    Google Scholar 

  • Naganuma, M. et al. TT virus prevalence, viral loads and genotypic variability in saliva from healthy Japanese children. Acta Paediatr. 97, 1686–1690 (2008).

    Google Scholar 

  • Okamoto, H. et al. Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis. J. Med. Virol. 56, 128–132 (1998).

    Google Scholar 

  • Ross, R. S., Viazov, S., Runde, V., Schaefer, U. W. & Roggendorf, M. Detection of TT virus DNA in specimens other than blood. J. Clin. Virol. 13, 181–184 (1999).

    Google Scholar 

  • Matsubara, H. et al. Existence of TT virus DNA in extracellular body fluids from normal healthy Japanese subjects. Intervirology 43, 16–19 (2000).

    Google Scholar 

  • Niel, C., Saback, F. L. & Lampe, E. Coinfection with multiple TT virus strains belonging to different genotypes is a common event in healthy Brazilian adults. J. Clin. Microbiol. 38, 1926–1930 (2000).

    Google Scholar 

  • Tyschik, E. A., Rasskazova, A. S., Degtyareva, A. V., Rebrikov, D. V. & Sukhikh, G. T. Torque teno virus dynamics during the first year of life. Virol. J. 15, 96 (2018).

    Google Scholar 

  • Gerner, P., Oettinger, R., Gerner, W., Falbrede, J. & Wirth, S. Mother-to-infant transmission of TT virus: prevalence, extent and mechanism of vertical transmission. Pediatr. Infect. Dis. J. 19, 1074–1077 (2000).

    Google Scholar 

  • Matsubara, H. et al. Existence of TT virus DNA and TTV-like mini virus DNA in infant cord blood: mother-to-neonatal transmission. Hepatol. Res. 21, 280–287 (2001).

    Google Scholar 

  • Schröter, M. et al. Detection of TT virus DNA and GB virus type C/Hepatitis G virus RNA in serum and breast milk: determination of mother-to-child transmission. J. Clin. Microbiol. 38, 745–747 (2000).

    Google Scholar 

  • Lim, E. S. et al. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat. Med. 21, 1228–1234 (2015).

    Google Scholar 

  • Reyes, A. et al. Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature 466, 334–338 (2010).

    Google Scholar 

  • Kaczorowska, J. & van der Hoek, L. Human anelloviruses: diverse, omnipresent and commensal members of the virome. FEMS Microbiol. Rev. 44, 305–313 (2020).

    Google Scholar 

  • McCann, A. et al. Viromes of one year old infants reveal the impact of birth mode on microbiome diversity. PeerJ 6, e4694 (2018).

    Google Scholar 

  • Liang, G. et al. The stepwise assembly of the neonatal virome is modulated by breastfeeding. Nature 581, 470–474 (2020).

    Google Scholar 

  • Liang, G. & Bushman, F. D. The human virome: assembly, composition and host interactions. Nat. Rev. Microbiol. 19, 514–527 (2021).

    Google Scholar 

  • Taboada, B. et al. The gut virome of healthy children during the first year of life is diverse and dynamic. PLoS ONE 16, e0240958 (2021).

    Google Scholar 

  • Walters, W. A. et al. Longitudinal comparison of the developing gut virome in infants and their mothers. Cell Host Microbe 31, 187–198.e3 (2023).

    Google Scholar 

  • Freer, G. et al. The vVirome and its major component, anellovirus, a convoluted system molding human immune defenses and possibly affecting the development of asthma and respiratory diseases in childhood. Front. Microbiol. 9, 686 (2018).

    Google Scholar 

  • Norman, J. M. et al. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 160, 447–460 (2015).

    Google Scholar 

  • McElvania TeKippe, E. et al. Increased prevalence of anellovirus in pediatric patients with fever. PLoS ONE 7, e50937 (2012).

    Google Scholar 

  • Sabbaghian, M., Gheitasi, H., Shekarchi, A. A., Tavakoli, A. & Poortahmasebi, V. The mysterious anelloviruses: investigating its role in human diseases. BMC Microbiol. 24, 40 (2024).

    Google Scholar 

  • Bai, G.-H., Lin, S.-C., Hsu, Y.-H. & Chen, S.-Y. The human virome: viral metagenomics, relations with human diseases, and therapeutic applications. Viruses 14, 278 (2022).

  • Zhao, G. et al. Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children. Proc. Natl. Acad. Sci. USA 114, E6166–E6175 (2017).

    Google Scholar 

  • Shah, S. A. et al. Expanding known viral diversity in the healthy infant gut. Nat. Microbiol. 8, 986–998 (2023).

    Google Scholar 

  • Zhang, Y. et al. The influence of early life exposures on the infant gut virome. Gut Microbes 17, 2501194 (2025).

  • Manrique, P. et al. Healthy human gut phageome. Proc. Natl Acad. Sci. USA 113, 10400–10405 (2016).

    Google Scholar 

  • Bisgaard, H. et al. Deep phenotyping of the unselected COPSAC2010 birth cohort study. Clin. Exp. Allergy 43, 1384–1394 (2013).

    Google Scholar 

  • Huang, P. et al. Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. J. Virol. 86, 4833–4843 (2012).

    Google Scholar 

  • Gozalbo-Rovira, R. et al. Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. PLoS Pathog. 15, e1007865 (2019).

    Google Scholar 

  • Currier, R. L. et al. Innate susceptibility to norovirus infections influenced by FUT2 genotype in a United States pediatric population. Clin. Infect. Dis. 60, 1631–1638 (2015).

    Google Scholar 

  • Stokholm, J. et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat. Commun. 9, 141 (2018).

    Google Scholar 

  • Christensen, E. D. et al. The developing airway and gut microbiota in early life is influenced by age of older siblings. Microbiome 10, 1–15 (2022).

    Google Scholar 

  • Rocchi, J. et al. Torquetenovirus DNA drives proinflammatory cytokines production and secretion by immune cells via toll-like receptor 9. Virology 394, 235–242 (2009).

    Google Scholar 

  • Zheng, H. et al. Torque teno virus (SANBAN isolate) ORF2 protein suppresses NF-kappaB pathways via interaction with IkappaB kinases. J. Virol. 81, 11917–11924 (2007).

    Google Scholar 

  • Peppas, I., Ford, A. M., Furness, C. L. & Greaves, M. F. Gut microbiome immaturity and childhood acute lymphoblastic leukaemia. Nat. Rev. Cancer 23, 565–576 (2023).

    Google Scholar 

  • Amir, A. et al. Gut microbiome development in early childhood is affected by day care attendance. NPJ Biofilms Microbiomes 8, 2 (2022).

    Google Scholar 

  • Hermes, G. D. A., Eckermann, H. A., de Vos, W. M. & de Weerth, C. Does entry to center-based childcare affect gut microbial colonization in young infants? Sci. Rep. 10, 1–13 (2020).

    Google Scholar 

  • Beller, L. et al. The virota and its transkingdom interactions in the healthy infant gut. Proc. Natl Acad. Sci. USA 119, e2114619119 (2022).

    Google Scholar 

  • Sims, A. et al. Superinfection exclusion creates spatially distinct influenza virus populations. PLoS Biol. 21, e3001941 (2023).

    Google Scholar 

  • Folimonova, S. Y. Superinfection exclusion is an active virus-controlled function that requires a specific viral protein. J. Virol. 86, 5554 (2012).

    Google Scholar 

  • Maqsood, R. et al. Breast milk virome and bacterial microbiome resilience in Kenyan women living with HIV. mSystems 6, e01079-20 (2021).

  • Azad, M. B. et al. Infant gut microbiota and the hygiene hypothesis of allergic disease: impact of household pets and siblings on microbiota composition and diversity. Allergy Asthma Clin. Immunol. 9, 15 (2013).

    Google Scholar 

  • Tun, H. M. et al. Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios. Microbiome 5, 40 (2017).

    Google Scholar 

  • Butkovic, A. et al. Evolution of anelloviruses from a circovirus-like ancestor through gradual augmentation of the jelly-roll capsid protein. Virus Evol. 9, vead035 (2023).

    Google Scholar 

  • Liou, S.-H. et al. Anellovirus structure reveals a mechanism for immune evasion. Preprint at bioRxiv https://doi.org/10.1101/2022.07.01.498313 (2022).

  • Deng, L. et al. A protocol for extraction of infective viromes suitable for metagenomics sequencing from low volume fecal samples. Viruses 11, 667 (2019).

  • Pearson, W. R. Finding protein and nucleotide similarities with FASTA. Curr. Protoc. Bioinformatics 53, 3.9.1–3.9.25 (2016).

    Google Scholar 

  • Enright, A. J., Van Dongen, S. & Ouzounis, C. A. An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res. 30, 1575–1584 (2002).

    Google Scholar 

  • Tordai, H. et al. Comprehensive collection and prediction of ABC transmembrane protein structures in the AI era of structural biology. Int. J. Mol. Sci. 23, 8877 (2022).

  • Bisgaard, H. et al. Childhood asthma after bacterial colonization of the airway in neonates. N. Engl. J. Med. 357, 1487–1495 (2007).

    Google Scholar 

  • Bisgaard, H., Hermansen, M. N., Loland, L., Halkjaer, L. B. & Buchvald, F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N. Engl. J. Med. 354, 1998–2005 (2006).

    Google Scholar 

  • Hanifin, J. M. & Rajka, G. Diagnostic features of atopic dermatitis. Acta Derm. Venereol. Suppl. 92, 44–47 (1980).

    Google Scholar 

  • Halkjaer, L. B. et al. Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children. Arch. Dermatol. 142, 561–566 (2006).

    Google Scholar 

  • Schoos, A.-M. M. et al. Atopic endotype in childhood. J. Allergy Clin. Immunol. 137, 844–851.e4 (2016).

    Google Scholar 

  • Stokholm, J. et al. Prevalence and predictors of antibiotic administration during pregnancy and birth. PLoS ONE 8, e82932 (2013).

    Google Scholar 

  • Bisgaard, H. et al. Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. N. Engl. J. Med. 375, 2530–2539 (2016).

    Google Scholar 

  • Chawes, B. L. et al. Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA 315, 353–361 (2016).

    Google Scholar 

  • R Core Team. A language and environment for statistical computing. R Foundation for Statistical Computing. https://www.R-project.org/ (2022).

  • Kembel, S. W. et al. Picante: R tools for integrating phylogenies and ecology. Bioinformatics 26, 1463–1464 (2010).

    Google Scholar 

  • McMurdie, P. J. & Holmes, S. Phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PLoS ONE 8, e61217 (2013).

  • Oksanen, J. et al. Vegan: community ecology package. Ordination methods, diversity analysis and other functions for community and vegetation ecologists. https://CRAN.R-project.org/package=vegan (2025).

  • De Cáceres, M. & Legendre, P. Associations between species and groups of sites: indices and statistical inference. Ecology 90, 3566–3574 (2009).

    Google Scholar 

  • Rohart, F., Gautier, B., Singh, A. & Cao, K.-A. L. mixOmics: an R package for ‘omics feature selection and multiple data integration. PLos Comput. Biol. 1 3, e1005752 (2017).

  • Max, K. Building predictive models in R using the caret package. J. Stat. Softw. 28, 1−26 (2008).

  • Ziegler, A. & Wright, M. N. Ranger: a fast implementation of random forests for high dimensional data in C++ and R. J. Stat. Softw. 77, 1−17 (2017).

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