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  • Collaborative project seeks safer therapies for ischemia and reperfusion injury

    Collaborative project seeks safer therapies for ischemia and reperfusion injury

    Southwest Research Institute (SwRI) and Trinity University will improve a prodrug, a compound activated in the body, to mitigate tissue and organ damage associated with heart attacks, strokes and traumatic injuries. These conditions…

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  • Chewy+ subscriptions strength helps extend the streak of growing ‘pegged’ customers

    Chewy+ subscriptions strength helps extend the streak of growing ‘pegged’ customers

    By Tomi Kilgore

    Retention was stronger than expected, boosting key Autoship numbers, after the annual fee for Chewy+ subscription rose to $79 from $49

    Chewy sees Autoship sales continuing to increase as a percentage of total sales, helped by growth in the Chewy+ subscription program.

    Chewy on Wednesday reported fiscal third-quarter sales that rose above expectations, as more people than expected stayed with the online pet-products retailer’s Chewy+ subscription program despite a sharp price hike.

    And that fueled continued growth in a key sales metric that the company values because it helps keep customers “pegged” to Chewy rather than moving to competitors.

    The company (CHWY) reported fiscal third-quarter Autoship customer sales, which are set to automatically repeat, with a discount, that jumped 13.6% from a year ago to $2.64 billion, above the average analyst estimate compiled by FactSet of $2.59 billion.

    And Autoship sales as a percentage of overall sales increased to 83.9% from 83% in the previous quarter and from 80% a year ago, to mark the seventh straight quarter-over-quarter increase.

    Autoship sales are valued because they are “highly predictable” and allow for planning to cut costs and improve profitability, Chief Executive Sumit Singh explained on the post-earnings call with analysts, according to an AlphaSense transcript. The program also helps the company retain its more loyal customers.

    “Autoship is a rinse and repeat product merchandise program that has high reliability and accuracy, both in terms of planning, in terms of delivery, and high satisfaction rating,” an executive said on the call.

    With more than 80% of its members “now pegged” to the Autoship program, the company believes it will continue to scale and become more efficient.

    Meanwhile, Chewy’s stock seesawed during the day but closed up 1.5%.

    But perhaps better than the growth of Autoship sales, Singh said the Chewy+ membership program “continues to outperform expectations” and is driving higher order frequency, broader category engagement and higher adoption of the mobile app. It’s also helping boost Autoship participation.

    The company launched Chewy+ at an introductory annual price of $49, with a 30-day free trial, then raised the price to $79 a year at the end of October. While some subscriber drop-off after the price increase was expected, Singh said early data shows “continued growth and strong conversion” from free to paid memberships at a rate that was higher than forecast.

    Overall sales for the quarter, which ran through Nov. 2, increased 8.3% from last year to $3.12 billion, just above the FactSet consensus of $3.10 billion.

    Net income rose to $59 million from $4.2 million, while earnings per share of 14 cents beat the FactSet consensus of 12 cents.

    If there was a negative to the earnings report, the company said it expects revenue for the current fourth quarter of $3.24 billion to $3.26 billion, compared with analyst expectations of $3.261 billion.

    The stock has gained 3.7% in 2025, while the S&P 500 index SPX has advanced 16.3%.

    -Tomi Kilgore

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    12-10-25 1924ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Following a Cat and Mouse Into Art History

    Following a Cat and Mouse Into Art History

    There’s a cliché in children’s book publishing: “My cat did something cute, and therefore I’m going to make a book out of it,” says children’s book author and illustrator Brian Lies. He succumbed to the impulse himself in Cat Nap…

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  • Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

    Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

    Synaptic plasticity — the brain’s ability to modify the connections between neurons to support learning — is one of the neural functions profoundly altered in Huntington’s disease, with a direct impact on brain function….

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  • Asian Stocks Advance as Fed’s Rate Cut Lifts Mood: Markets Wrap

    Asian Stocks Advance as Fed’s Rate Cut Lifts Mood: Markets Wrap

    (Bloomberg) — Asian equities echoed gains on Wall Street after the Federal Reserve cut interest rates and Chair Jerome Powell voiced optimism that the US economy will strengthen as the inflationary impact from tariffs fades away.

    The MSCI Asia Pacific Index rose 0.5% in early trade, led by the tech and financial sectors. That’s after the S&P 500 closed up 0.7% on Wednesday, just short of all-time highs, while the Russell 2000 gauge of small-caps jumped 1.3% to a record. Bonds rallied as the Fed’s quarter-point rate reduction was accompanied by the authorization of fresh Treasury bill purchases to rebuild bank reserves.

    Nasdaq 100 futures were down 0.3% early in Asia as disappointing results from Oracle Corp. dealt the bullish sentiment a partial blow as markets closed in New York. Shares of the company, whose fate is deeply tied to the artificial intelligence boom, plunged in post-market trading. Nvidia Corp.’s stock also edged lower.

    Delivering a third consecutive cut, Powell suggested the Fed had now done enough to help stabilize the threat to employment while leaving rates high enough to continue weighing on price pressures. Officials maintained their outlook for just one cut in 2026 and upgraded their median outlook for growth.

    “The combination of stronger growth expectations and softer inflation forecasts has increased market expectations for Fed rate cuts,” said Tomo Kinoshita, global market strategist at Invesco Asset Management Japan Ltd. “In Asia, I anticipate a positive tone for equities and currency appreciation. Export-oriented stocks should benefit from improved US growth prospects.”

    Nine out of 12 voters on the Fed’s rate-setting committee supported the decision to lower rates. The reduction and the Fed’s tone matched Wall Street expectations for a “hawkish cut” while officials left intact their outlook for a single cut in 2026.

    The US 10-year yield fell around four basis points Wednesday, stalling a prior run up in yields that pushed one global gauge to its highest since 2009, while the policy-sensitive two-year yield fell eight basis points. The dollar weakened.

    In Asia, traders will be watching an auction of 20-year Japanese government bonds and an interest-rate decision in the Philippines today.

    Earlier, Bank of Canada held rates steady, saying current borrowing costs were appropriate to mitigate the trade war damage.

    In commodities, gold held gains after the Fed cut while silver pushed to new highs. Oil extended an advance after the US seized a sanctioned tanker off Venezuela, deterring more shipments from the South American producer and raising the risk of a conflict.

    The impact of President Donald Trump’s on-again, off-again tariff offensive has been a key consideration in how the Fed approaches efforts to bring inflation back down to its 2% target. Without the levies, inflation is probably “in the low 2s” right now, Powell said at the press conference following the decision. And their impact is likely to weaken in the second half of next year.

    Powell also underscored the importance of upcoming economic reports while advising caution on assessing household jobs readouts, given technical distortions after a government shutdown caused a data blackout.

    “The Fed emphasized that future moves will be data-dependent, shifting firmly to a meeting-by-meeting approach,” said Daniel Siluk, a portfolio manager at Janus Henderson Investors. “Chair Powell reinforced this stance in his press conference, noting that the Committee sees today’s cut as a ‘prudent adjustment’ rather than the start of a new cycle.”

    Corporate News

    SK Hynix Inc. fell after South Korea’s main bourse issued a higher-level warning on investing in the stock following strong gains sparked by expectations of a listing in New York. President Donald Trump signaled he’ll oppose a Warner Bros. Discovery Inc. deal that doesn’t include new ownership of CNN, a potential wrinkle for the bid from Netflix Inc. Japan’s stock market is witnessing a record wave of large private transactions known as block trades, stemming from companies reducing cross-shareholdings to improve corporate governance. Chinese artificial intelligence startup DeepSeek has relied on Nvidia Corp. chips that are banned in the country to develop an upcoming AI model, according to a new report in The Information. Coca-Cola Co. said Chief Executive Officer James Quincey is stepping down and will be replaced at the end of March by Henrique Braun, the company’s chief operating officer. Some of the main moves in markets:

    Stocks

    S&P 500 futures fell 0.1% as of 9:29 a.m. Tokyo time Hang Seng futures rose 0.3% Japan’s Topix rose 0.1% Australia’s S&P/ASX 200 rose 0.7% Currencies

    The Bloomberg Dollar Spot Index was little changed The euro was little changed at $1.1700 The Japanese yen rose 0.2% to 155.65 per dollar The offshore yuan was little changed at 7.0574 per dollar The Australian dollar was little changed at $0.6672 Cryptocurrencies

    Bitcoin fell 0.7% to $91,784.62 Ether fell 0.8% to $3,313.66 Bonds

    The yield on 10-year Treasuries declined one basis point to 4.14% Japan’s 10-year yield declined 1.5 basis points to 1.940% Australia’s 10-year yield declined nine basis points to 4.72% Commodities

    West Texas Intermediate crude rose 0.6% to $58.83 a barrel Spot gold rose 0.3% to $4,240.47 an ounce This story was produced with the assistance of Bloomberg Automation.

    –With assistance from Winnie Hsu.

    ©2025 Bloomberg L.P.

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  • Can school meal programs improve health and educational goals in children experiencing socioeconomic disadvantage?

    Key messages

    • School meal programs in low- and middle-income countries lead to a small increase in math test scores, but may have little to no effect on reading test scores. School meals lead to a small increase in enrollment, but may have little…

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  • Australia leader defends social media ban as teens brag about staying online – Reuters

    1. Australia leader defends social media ban as teens brag about staying online  Reuters
    2. Australia social media ban: Teens navigate new world without social media as ban takes effect  BBC
    3. ‘This is the end’: Australian teens mourn loss of social media…

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  • NASA just lost contact with a Mars orbiter, and will soon lose another one

    NASA just lost contact with a Mars orbiter, and will soon lose another one

    Technicians work on the MAVEN spacecraft at NASA’s Kennedy Space Center in Florida ahead of its launch in 2013.


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  • Federal Reserve cuts interest rates by 0.25%, Powell says there’s ‘no risk-free path’

    Federal Reserve cuts interest rates by 0.25%, Powell says there’s ‘no risk-free path’

    Markets reacted positively after the Fed cut interest rates by a quarter point on Wednesday.

    And part of the optimism seems to be around the Fed’s outlook for the economy, which it sees growing at a 2.3% rate in 2026 after this year’s 1.7% GDP growth.

    “The take on productivity and growth is very risk-friendly,” Evercore ISI’s Krishna Guha wrote in a note on Wednesday. “The Fed chair suggests productivity may be running about 2%, allowing the economy to grow faster without generating excess inflation.”

    In essence, lower rates, falling inflation, and faster economic growth is a recipe for higher corporate profits, a stabilization in the labor market, and as evidenced on Wednesday, higher stock prices.

    Fed officials expected to make one more rate cut next year, the same number projected in September. As of Wednesday afternoon, markets were pricing in additional rate cuts in April and June.

    Guha said Powell sounded “very upbeat on productivity and growth, including AI effects,” during his press conference on Wednesday.

    Adding Powell came across with a “calm rather than edgy in tone, suggesting he is comfortable and in charge rather than on the ropes as in October.”

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  • Hidden infections may play a key role in driving long COVID symptoms

    Hidden infections may play a key role in driving long COVID symptoms

    For millions suffering from long COVID, their persistent breathlessness, brain fog and fatigue remain a maddening mystery, but a group of leading microbiologists think they may have cracked the case. 

    The culprit for some long…

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