Christian Horner was left to rue a “very frustrating” sequence of events in Sunday’s Austrian Grand Prix after Red Bull left their home race without scoring any points.
Max Verstappen completed only two corners at the Red Bull Ring before being taken out of the action by Mercedes rival Kimi Antonelli, who misjudged his approach to Turn 3 and subsequently earned a three-place grid penalty for Silverstone.
Yuki Tsunoda, meanwhile, was the final finisher in 16th position, having struggled to make an impression after his Q1 exit and been given a 10-second penalty for tipping Franco Colapinto’s Alpine into a spin exiting Turn 4.
The result means Red Bull fall even further behind their rivals in the Teams’ Championship, holding 162 points to McLaren’s 417, while Verstappen is 61 adrift of Oscar Piastri in the Drivers’ standings.
“A frustrating day,” Red Bull team boss Horner summed up on F1 TV’s post-race show. “Starting with Max, he had a great start and was well-positioned for Turn 1. At Turn 3 unfortunately Kimi just lost control and wiped him out. Very frustrating… Obviously Kimi’s apologised. It is what it is.
“I think when you look at the pace, we wouldn’t have fought the McLarens today, but we’d have fought the Ferraris hard, for sure. George [Russell] had no pace. It was frustrating.
“With Yuki, it’s difficult to make progress starting where he did on the grid, then picking up a penalty as well with Colapinto. A horrible race for him today as well. Frustrating, but we’ll move on quickly to Silverstone.”
With that in mind, Horner was asked how Red Bull can “remedy” the struggles several drivers have now faced in the seat alongside Verstappen – and ensure that both cars are in a position to score points moving forward.
“We need to understand with Yuki what’s gone wrong [this weekend],” he continued. “FP1 and FP2, certainly FP2 and FP3, he was looking okay. Qualifying it seemed to fall apart for him.
“When you’re out of position, you’re down the pack like that, when it’s so tight… he’s struggling, I think he’s struggling for confidence. But we’ll work with him, we’ll try and help him through it.
“The car is… it’s a car that’s evolved over the years around the development path that we’ve taken. It isn’t an easy car to drive, but it’s not that difficult either. We’ll work with him and hopefully it’ll make a step up in Silverstone.”
Given the significant gaps that have developed in both championships, Horner knows Verstappen and Red Bull now face a tall order to add to their recent title successes in 2025.
“Well, look, the championship we’re not even thinking about,” he conceded. “We’re just focused on each race now. They’re [McLaren] a long way out of touch. We’ll just take things race by race.
Verstappen has won the last four Drivers’ titles on the bounce, while Red Bull were crowned Teams’ champions in 2022 and 2023 before being overhauled by McLaren last season.
Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function. Because of this, water molecules represent a powerful but largely underappreciated foothold in drug binding studies. Yet structural data about these water networks, usually collected at freezing temperatures, often carry temperature-based structural artifacts. St. Jude Children’s Research Hospital scientists have unveiled a new computational tool called ColdBrew to address this problem. The tool leverages data on extensive protein water networks to predict the likelihood of water molecule positions within experimental protein structures, potentially aiding drug discovery efforts. ColdBrewwas published today in Nature Methods.
Proteins have evolved to fold precisely according to the repulsion and attraction of their amino acid building blocks to water. Water is also key to their activity since it helps guide other molecules, including drug molecules, to bind effectively. Drug discovery efforts based on protein structures use techniques such as X-ray crystallography and cryo-electron microscopy, but these techniques use freezing, or “cryogenic” temperatures, which can distort how water molecules appear. Marcus Fischer, PhD, St. Jude Department of Chemical Biology & Therapeutics, recognized this as a missed opportunity.
Water molecules in protein structures have so many degrees of freedom that drug discoverers typically throw them out. They’re kind of inconvenient.”
Marcus Fischer, PhD, St. Jude Department of Chemical Biology & Therapeutics, corresponding author on the study
With ColdBrew, seeing is believing
To put this lost information to work, Fischer and first author Justin Seffernick, PhD, St. Jude Department of Chemical Biology & Therapeutics, developed ColdBrew. “Our goal was to make a tool that’s easy to use and understand,” said Seffernick. “For each water molecule, our method can tell us how likely water is to be present at higher temperatures. We also found that this same metric can give us clues about how ligands bind to proteins.”
This is particularly important to drug discovery. “When ligands bind to proteins, they kick out water from binding sites, so we need to pay attention to them in ligand design,” said Fischer. “Encouragingly, we’ve seen in our data that our predictions were best within these binding sites and around ligands.”
Considering that cryogenic structure-solving techniques can artificially increase the number of water molecules present in a structure, a tool such as ColdBrew can assure researchers that seeing is believing. To this end, Fischer and Seffernick have amassed and made publicly available a comprehensive library based on ColdBrew calculations.
“To enable the wide use of ColdBrew, we performed calculations on every structure that fit our criteria in the entire Protein Data Bank. We have over 100,000 predictions, which is over 46 million water molecules,” Fischer said. “Remarkably, our results show that drug designers unknowingly avoid tightly bound waters, so actually knowing which ones to avoid could guide the process.”
Authors and funding
The study was supported by grants from the National Institutes of Health (R35GM142772) and the American Lebanese Syrian Associated Charities (ALSAC), the fundraising and awareness organization of St. Jude.
Source:
St. Jude Children’s Research Hospital
Journal reference:
Seffernick, J. T., & Fischer, M. (2025). An experimental proxy of water displaceability for ligand discovery. Nature Methods. doi.org/10.1038/s41592-025-02724-0.
Amazon’s Prime Day sale is just over a week away, and iPad prices on the retailer’s website are starting to reflect that.
SEE ALSO:
These Prime Day deals landed early — save on Apple, Ninja, and Samsung gadgets
Though Apple deals can range from decent to great at Amazon year round, Prime Day tends to bring a higher concentration for deals. Though the sale doesn’t kick off until July 8, the site already marked down every single model of the iPad, from the mini to the Pro.
Below, you’ll find our top picks for each model, but if nothing catches your eye so far, don’t worry — we’ll be updating this list all the way through Prime Day.
Best iPad deals
Why we like it
Check out Mashable’s full review of the iPad mini.
Mashable Deals
The iPad mini may not be the best tablet for creatives or professionals who need the highest-powered tablet out there. However, for folks who mostly enjoy using their tablet for streaming or reading, this ultra-portable tablet checks the boxes. The 128GB of storage will likely be more than enough for less intensive tasks, and at 8.3-inches, it feels comfortable to hold for longer periods of time. (For anyone not particularly into the tech color e-readers are offering at the moment, this iPad gives a great alternative with some more versatility).
APP36-300625 KARACHI: June 30 – Police stop the protesters belonging to Sindh Employees Association outside the Press Club. APP/SDQ/TZD
APP37-300625 KARACHI: June 30 – Police use tear gas to disperse protesters belonging to Sindh Employees Association outside the Press Club. APP/SDQ/TZD
‘The big risk is that market participants balk at the amount of bills that are coming to the market,’ said strategist Lawrence Gillum of LPL Financial
Investors have been enjoyed a more than monthlong rally in the 30-year U.S. government bond that pushed its yield below 5% in June, partly as the result of growing expectations for 2025 rate cuts by the Federal Reserve.
June’s bond-market rally, however, could give way to a different trading dynamic in July that results in a fresh round of volatility in the government’s shortest-term debt obligations, known as Treasury bills.
This volatility showed signs of beginning to surface on Monday, with a spike in the yield on the 1-month Treasury bill BX:TMUBMUSD01M to almost 4.19%.
For much of this year, longer-duration U.S. government bonds took the brunt of investors’ concerns about the fiscal outlook and a rising federal deficit, as demonstrated by the sharp selloff seen in the 30-year bond in April and May. Bond yields and prices move in the opposite direction.
Helping to ease those concerns lately have been stable inflation data, expectations for a wobbly labor market going forward, rising market-implied probabilities of Fed rate cuts starting as soon as July, and speculation that President Donald Trump may pick a successor to Fed Chair Jerome Powell who might lean more toward lowering interest rates sooner, said Derek Tang, an economist at Monetary Policy Analytics in Washington.
Now, changes being made in the Senate to Trump’s big bill of tax breaks and spending cuts could increase the national deficit by almost $3.3 trillion between 2025 and 2034, according to the nonpartisan Congressional Budget Office. Government deficits require increased issuance of Treasurys to finance the shortfall between government spending and revenue. One of the most important questions now is how much of that issuance will come in the form of short-term T-bills that mature in a year or less, or longer-dated maturities anywhere between two to 30 years out. Trump, who wants to sign a final version of the bill by July 4, indicated during a press conference last week that he favors using T-bills over longer-dated Treasurys, saying that “I’ve instructed my people not to do any debt beyond nine months or so.” Read: A 2-month rally pushed the stock market to record highs – but watch for these risks in JulyIf the president’s bill gets through Congress and signed into law, concerns about too much supply of Treasurys and possibly not enough demand will be back in play, albeit in the shortest-term part of the market, said Lawrence Gillum, the Charlotte, North Carolina-based chief fixed-income strategist for broker-dealer LPL Financial. These issues have the potential to translate into higher short-term T-bill rates than would otherwise be the case, and a lack of investor demand at future bill auctions, he said. However, yields on longer-dated Treasurys could fall, offering some relief for investors, Gillum added. “The big risk is that market participants balk at the amount of bills that are coming to the market,” he said via phone. “They may not want to digest all of that. This could be disruptive to the front end of the curve and move yields there higher.” He notes that the Treasury Borrowing Advisory Committee, which advises the U.S. Treasury, has recommended that up to 20% or slightly higher, of the government’s outstanding debt be in the form of bills, but this number could increase. If the bill doesn’t make it through Congress or into law, “then we have to worry about the debt-ceiling limit,” Gillum said, noting that the U.S. risks running out of enough cash to fund all its obligations in August without a new debt-limit deal. The debt ceiling is the limit placed on the total amount of money that the government is authorized to borrow to meet existing obligations. If Congress fails to increase or suspend this limit, “Treasury won’t have the money to pay its bills,” potentially at some point in August, which could have the most negative impact on bills set to mature that month, the strategist said
Monday’s trading session was relatively quiet due to a lack of major data releases, and appeared to be largely driven by month-end buying that pushed one- BX:TMUBMUSD01Y through 30-year yields BX:TMUBMUSD30Y lower. Meanwhile, all three major U.S. stock indexes DJIA SPX COMP advanced in New York afternoon trading.
According to Tang of Monetary Policy Analytics, “we might be heading into a very choppy period” for the Treasury market.
The recent decline in bond yields gives the Trump administration “a little more wiggle room in terms of financing costs so that if there is a plan to increase borrowing, you could argue that the overall cost could be lower because yields are so low,” Tang said via phone on Monday.
Still, volatility in T-bills can’t be completely ruled out if Trump’s bill is enacted into law. However, “you could convince the market that short-term yields will be lower even with greater supply, while longer-run yields could rise on any loss of Fed credibility or if inflation expectations blow up.”
Read: The wrong kind of Fed rate cuts are coming, says JPMorgan. What that means for stocks, bonds and the dollar.
-Vivien Lou Chen
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
Amazon Prime Day is still a few days away, but I’ve already spotted a pretty tempting saving on one of our favourite five-star pairs of wireless earbuds.
The Sony WF-1000XM5 have been one of our go-to recommendations for quite some time now, and the black finish is now available for £189 over at Amazon. This price isn’t a million miles away from their lowest ever price of £175 and still represents a very healthy £84 saving.
Now, obviously, you can go ahead and buy now if you feel the urge to get the deal done, but this might be one product that is destined to dip a little further when Prime Day actually kicks off on Tuesday, 8th July.
Best Sony WF-1000XM5 wireless earbuds deal
The Sony WF-1000XM5 are still among the best wireless earbuds in town, despite being around three years old.
Other flagship rivals have been and gone, yet the Sonys are still there, mixing it up with the very best of Bose, JBL, Technics and more.
The XM5 support Sony 360 Reality Audio, Multipoint Bluetooth, Adaptive Sound Control and the brand’s handy Speak-to-Chat feature. The responsive touch controls are also flexible, allowing you to change volume and sound modes simultaneously.
Battery life is eight hours from a single charge, with the carry case adding an extra 16 hours to the equation.
In our Sony WF-1000XM5 review, we said, “There’s an openness which we haven’t really heard from wireless earbuds at this level before, and the definition and texture that shines through is quite exceptional”.
Their sound is balanced and cohesive, with the Sonys boasting a superb sense of timing and rhythmic drive.
Now £189 at Amazon isn’t the lowest price we’ve spotted the Sony WF-1000XM5 at. They hit £175 back in December last year, and I honestly wouldn’t be surprised to see them drop this low long-term, possibly starting on Amazon Prime Day, which runs from the 8th July to the 11th July.
Could they drop even lower? We’ll have to wait and see.
MORE:
Our pick of the best wireless earbuds for every budget
Bose QuietComfort Ultra Earbuds vs Sony WF-1000XM5: which are better?
AirPods Pro 3: everything we know so far and 5 features we want from Apple’s next flagship wireless earbuds
Fiat heir Lapo Elkann is stepping into the footwear world with a new investment.
This month, the great-grandson of Fiat founder Giovanni Agnelli became a minority investor in Miami-based luxury footwear brand Blu Scarpa. While terms of the deal were not disclosed, the new partnership was unveiled at Milan Men’s Fashion Week this month at the shoe brand’s spring/summer 2026 collection presentation.
Matthew Chevallard, founder and creative director of Blu Scarpa, said that Elkann’s new partnership will allow the company to scale outside of its Miami home.
“Lapo has believed in me and supported me throughout my footwear journey, and now with this investment, it will allow me to embark on a new chapter,” Chevallard told FN in an interview. “Bringing Lapo on as a partner will allow us a little more wind in our sails to still be very independent, but obviously, have a slightly more resources to compete.”
The executive noted that since the company launched in 2019, he has built a solid foundation in Miami through the company’s own store in the Design District.
“Now we’re moving outside of that micro mentality,” Chevallard noted. “We now want to move into more conventional practices like expanding wholesale and amplifying our messaging to a wider audience.”
Styles from Blu Scarpa’s spring/summer 2026 collection.
Courtesy of Blu Scarpa
Blu Scarpa sells to The Webster as well as Level Shoes in Dubai. “We are working on expanding out relationship with Level, especially since they are slated to open their first U.S. store here in Miami in a few years.” (Level has not confirmed the opening.)
Chevallard is no stranger to the footwear industry. Much of his entrepreneurial spirit is expressed through footwear, starting with the luxury men’s slipper brand Del Toro that he co-founded in 2005.
Now, with Blu Scarpa, Chevallard is focusing in on Italian craftsmanship that takes inspiration from the golden age of 1980s and ‘90s Italian lifestyle and artistic icons such as Lucio Fontana, Georgia O’Keeffe, Donald Judd, and Yves Klein.
For spring/summer 2026, the collection has expanding into the realm of soccer, showcasing a new silhouette alongside new iterations of the brands core models. The offering is made up of five distinct capsules, with prices ranging $475 to $535.
A highlight of the new offering includes the 2.0 Blu Palm shoe, which is described as a continuation of the Blu Palm concept in suede and nylon, originally launched in collaboration with Elkann and Chevallard. Another highlight is the aforementioned Soccer Collezione, which is inspired by 1980s–1990s soccer sportswear. The line introduces a brand-new suede and leather silhouette that brings soccer into Blu Scarpa’s running and tennis-focused sportswear realm.
Israel ramped up its offensive in Gaza on Monday, with new displacement orders sending tens of thousands of people fleeing the north of the devastated territory and waves of airstrikes killing about 60 Palestinians, according to local officials and medical staff.
The violence in Gaza came as a senior adviser to Benjamin Netanyahu, Israel’s prime minister, was due to arrive in Washington for talks on a new ceasefire, a day after Donald Trump called in a social media post for a deal to end the 20-month war and free 50 hostages held by Hamas.
Ron Dermer, the strategic affairs minister and a close confidant of Netanyahu, is expected to meet senior US officials to discuss ongoing indirect negotiations with Hamas, the aftermath of Israel’s war against Iran and the possibility of regional diplomatic deals.
An Israeli government spokesperson told reporters on Monday that Netanyahu was working to end the war in Gaza “as soon as possible” through the release of the hostages, of whom more than half are thought to be dead, and the defeat of Hamas. A US official said Netanyahu would travel to the US on 7 July to meet Donald Trump.
The new “evacuation orders” warned of impending assaults around densely populated Gaza City and told Palestinians to head south to overcrowded coastal zones, where there are few facilities and limited water. About 80% of Gaza is now covered by such orders or controlled by the Israel Defense Forces (IDF).
The orders also said that the IDF planned to advance into the centre of Gaza City to fight Hamas militants based there.
On Monday, Israeli tanks and infantry pushed into the Zeitoun neighbourhood on the eastern edge of Gaza City and shelled several areas in the north, while aircraft bombed at least four schools after ordering hundreds of families sheltering inside to leave, residents said.
“Explosions never stopped; they bombed schools and homes. It felt like earthquakes,” said Salah, 60, from Gaza City. “In the news we hear a ceasefire is near; on the ground we see death and we hear explosions.”
In the afternoon, an airstrike hit a crowded cafe on the shore in Gaza City, killing at least 22 people, including women, children and a local journalist.
The IDF said it struck militant targets in northern Gaza, including command and control centres, after taking steps to mitigate the risk of harming civilians.
Analysts have detected changes in the rhetoric of senior Israeli officials in recent days, which may suggest a new ceasefire is now being considered.
Throughout the conflict, Israeli attacks have intensified at significant moments in negotiations. Israeli officials have said one aim of Israel’s latest offensive, which was launched in May after the breakdown of a two-month ceasefire in March, was to seize territory that could later be given up during talks as a “bargaining chip”.
On Friday, Eyal Zamir, the IDF chief of staff, said the offensive was close to having achieved its goals. Netanyahu has also reinforced his political position within Israel and so is better placed to ignore threats by rightwing coalition allies to withdraw support in the event of a deal with Hamas.
A deal remains difficult though, officials close to the negotiations said, with both Israel and Hamas sticking to previous incompatible positions.
Hamas is demanding that Israel agrees to a definitive end to the war and is refusing to disarm. Israel refuses Hamas demands to withdraw entirely from Gaza and says it will end its campaign only when the militant organisation has given up its weapons and its leaders have agreed to leave the territory.
Yair Lapid, the Israeli opposition leader, on Monday added his voice to those in Israel calling for an end to the war in Gaza.
“There is no longer any benefit for the state of Israel from continuing the war in Gaza. Only damage on the security, political and economic level,” Lapid told a meeting of parliamentarians. “The army has no more objectives in Gaza.”
A public opinion poll published the day after Tuesday’s ceasefire with Iran by public broadcaster Kan showed that nearly two-thirds of respondents wanted the Gaza war to end. The result was in line with dozens of similar polls in recent months. Israel’s military has suffered significant casualties this month, which has added to the public pressure for a deal.
Nasser hospital in Khan Younis said on Monday it had received the bodies of 11 people who were shot while returning from an aid site associated with the Israeli and US-backed Gaza Humanitarian Fund in southern Gaza, Ten others were killed at a United Nations aid warehouse in northern Gaza, according to the health ministry.
The Israeli military acknowledged on Monday that Palestinian civilians had been harmed as they sought food from distribution centres in Gaza and other locations, saying that instructions had been issued to forces after “lessons learned”.
Food, fuel and other basics are scarce in Gaza, with distributions by the GHF coming nowhere close to meeting the needs of 2.3 million people.
Israel says Hamas steals aid to finance military and other operations. The group denies that accusation and aid agencies say their monitoring systems are robust.
The war began when Hamas-led militants attacked into southern Israel on 7 October 2023, killing 1,200 people, mostly civilians, and taking 251 hostages back to Gaza.
Israel’s subsequent military assault has killed more than 56,500 Palestinians, mostly civilians, displaced almost the entire 2.3 million population and reduced much of the territory to rubble.
Wimbledon 2025 – Carlos Alcaraz shows champion mentality in SW19
The sounds of SW19 flowed across the pristine grounds of the All England Lawn Tennis Club. The popping of champagne corks, the ovation for national heroes David Beckham and Gareth Southgate – this is the Championships in its essence.
It was a battle of the generations, tradition versus modernity, 16 years in age between the pair. Tradition has also been forced to adapt; for the first time in the competition’s 148-year history, the courts are not surrounded by line judges.
Alcaraz did not feel he was at his best level, yet champions will always find a way to win even when they are not in full flow. For the 22-year-old, his 2025 opener at Wimbledon was a prime example, despite being on an 18-match winning streak.
Fognini was determined not arrive at Centre Court as a spectator, playing in his last of 15 Championships. While he played with freedom and nothing to lose, Alcaraz grew frustrated and needed to keep cool in the heat to maintain his grip on the match.
It was a vintage performance for former Australian Open doubles champion Fognini, playing his serve-and-volley game to perfection, while his five return winners were a joy to witness on Centre Court.
After suffering in the fourth set, Alcaraz turned ruthless in the decider and won three games without a reply, before a medical emergency in the crowd paused the match. The Spaniard brought over a bottle of water, waited patiently and closed out the bout upon returning to the grass.
There was a silver lining for Fognini: his son, Federico, flew to London upon learning that his father would play Alcaraz. After the match, he asked the Spaniard for his shirt as a gift for his son. Even after the battle, the sportsmanship remains on Centre Court.
