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  • PML-N Senator Irfan Siddiqui passes away – RADIO PAKISTAN

    1. PML-N Senator Irfan Siddiqui passes away  RADIO PAKISTAN
    2. PML-N Senator Irfan Siddiqui passes away in Islamabad after brief illness  Dawn
    3. Senator Siddiqui admitted to ICU due to respiratory complications, says family  Geo News
    4. PML-N Senator Irfan…

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  • Wiggles admit likely consumer law breach over Emma Bow headbands with button batteries | The Wiggles

    Wiggles admit likely consumer law breach over Emma Bow headbands with button batteries | The Wiggles

    Children’s entertainers the Wiggles have admitted to selling headbands to kids without warning about the dangers of button batteries contained within the products.

    More than 3,100 Emma Bow headbands, which have four flashing lights powered by button batteries, were sold at live concerts, retailers and online between June 2022 and March 2024.

    A legally enforceable undertaking signed by the blue Wiggle, Anthony Field, outlined the Wiggles’ admission that failing to include a headband safety warning likely breached Australian consumer law.

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    The yellow and black Emma Bow headbands were recalled in August 2024 by the manufacturer CA Australia over safety concerns for young children who could choke by ingesting the small, shiny batteries.

    In a statement by the ACCC on Tuesday, its deputy chair, Catriona Lowe, said button batteries posed a significant risk to young children and mandatory standards were important in helping to prevent injuries.

    “Without a warning on the product, parents may not have known it contained button batteries and not understood the severity of the risk,” Lowe said.

    “If swallowed, a button battery can become stuck in a child’s throat and result in catastrophic injuries, and even death, in as little as two hours.”

    As part of its cooperation with the ACCC’s investigation, the Wiggles committed to produce an episode of its Wiggle Talk podcast discussing safety issues relating to button batteries and children’s toys.

    The manufacturer also pledged to improve its compliance with consumer law.

    Researchers have previously found approximately 200 children are potentially exposed to button battery injury in Australia each year, and at least a dozen experience severe injury.

    The batteries have also been linked to the deaths of three children in Australia, according to the watchdog, in incidents unrelated to the Emma Bow headbands.

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    The safety admission is the latest legal trouble for the Wiggles after it was sued by its former CEO Luke O’Neill.

    The former boss launched legal action in the federal court in September, arguing he was dismissed without a reasonable basis by the group after complaining about the hiring of Field’s friends and family members.

    But the Wiggles denied the allegations and alleged the former CEO was fired because his “overall performance was not satisfactory” and necessary trust in him had been lost.

    A settlement was negotiated between both parties in October, news.com.au reported.

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    TOKYO, Nov 11 (Reuters) – Japan’s industry ministry is seeking changes to the law so that public money can be used for investment in the nuclear power sector and in electricity grids, the Nikkei business daily reported on Tuesday.

    New Prime Minister Sanae Takaichi has said reviving nuclear power is key to Japan’s energy security and the industry wants greater support for new reactor building, particularly as the boom in artificial intelligence and data centres spurs demand for more electricity.

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    The ministry aims to present a proposal to a working group with the hope that a bill to amend the law will be passed in parliament next year.

    In July, Kansai Electric Power (9503.T), opens new tab, Japan’s top nuclear power operator, announced it was conducting initial studies to build a new reactor in western Japan – the first concrete step towards building a reactor since the Fukushima Daiichi nuclear plant meltdowns in 2011.

    Reporting by Katya Golubkova; Editing by Edwina Gibbs

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  • GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

    GLP-1 drugs beat metformin for weight control in teens with type 2 diabetes

    A new real-world study reveals that advanced GLP-1 therapies, including semaglutide and tirzepatide, provide comparable glycemic control while offering superior weight benefits compared to metformin in adolescents newly diagnosed with type 2 diabetes.

    Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study. Image Credit: Meteoritka / Shutterstock

    In a recent study published in the Journal of Pediatric Endocrinology and Metabolism, researchers compared the efficacy of metformin and GLP-1–based therapies, including GLP-1 receptor agonists and the dual GIP/GLP-1 agonist tirzepatide, in youth newly diagnosed with type 2 diabetes (T2D).

    Aggressive Nature and Treatment Challenges of Youth-Onset T2D

    Youth-onset T2D progresses rapidly, with early onset of complications in adulthood. Metformin remains the first-line therapy for newly diagnosed pediatric patients; however, while it effectively lowers glycated hemoglobin (HbA1c), it has minimal effects on weight loss and limited durability in glycemic control. GLP-1–based therapies, already recommended in adults, are gaining traction in younger populations due to their glucose-lowering and weight-reducing effects.

    Rationale for Exploring High-Potency GLP-1 Therapies

    Several GLP-1 receptor agonists are approved for pediatric T2D, supported by guidelines as adjunctive treatments to metformin. Yet, approved pediatric doses yield modest weight benefits. This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group.

    Study Design and Population Characteristics

    This retrospective, real-world study extracted data from electronic medical records of an urban pediatric hospital. Eligible participants were youth with newly diagnosed T2D who received GLP-1RA or metformin monotherapy between January 2022 and March 2024. Exclusion criteria included combination therapy, insulin as first-line treatment, and diabetes secondary to other causes.

    Collected variables included demographics, diabetes duration, BMI, HbA1c, BMI z-scores, medication type and dose, and adverse effects. All participants were publicly insured. The primary outcomes were monthly changes in HbA1c and percent BMI within the first year post-diagnosis, with secondary outcomes assessing median changes in HbA1c, BMI, and z-scores.

    Baseline Demographics and Medication Profiles

    A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy. The GLP-1RA group was predominantly female (83%) compared to 51% in the metformin group, and fewer individuals identified as Latino (41.7% vs 69.9%). The most prescribed GLP-1RA was semaglutide 1 mg (33%), followed by tirzepatide 7.5 mg (25%). Higher-potency formulations (semaglutide up to 2.4 mg and tirzepatide) were used, which may account for stronger weight effects compared to pediatric trials that employed lower doses. Seven GLP-1RA recipients reported gastrointestinal adverse effects such as nausea, vomiting, and constipation.

    Comparative Glycemic and Anthropometric Outcomes

    Baseline HbA1c levels were similar across groups. At follow-up, unadjusted analyses showed lower HbA1c in the GLP-1RA group (36 vs 44 mmol/mol, p = 0.03), but adjusted models revealed no statistically significant monthly HbA1c change (β −1.1, p = 0.308). Median HbA1c decreased by 8.7 mmol/mol with metformin and 14.2 mmol/mol with GLP-1RA therapy.

    Regarding weight outcomes, GLP-1RA recipients exhibited greater BMI reduction (−0.43 kg/m² per month) compared with metformin (−0.01 kg/m² per month). Adjusted regression analysis indicated an approximately 1% additional monthly BMI reduction with GLP-1 therapy (β = −1.08%, p = 0.001). Final percent BMI reduction was −5.1% for GLP-1RA and −0.59% for metformin, with corresponding z-score decreases of −0.02 and −0.01, respectively.

    Interpretation of Efficacy and Safety Findings

    At study completion, 83% of GLP-1RA users and 67% of metformin users achieved the target HbA1c of 48 mmol/mol. Although glycemic control was comparable, GLP-1RA therapy conferred superior weight reduction benefits. Adverse events were limited to gastrointestinal symptoms, consistent with the known pharmacological effects of GLP-1. The small sample size of the GLP-1RA, however, limits generalizability, and baseline BMI differences may have influenced the observed outcomes.

    Study Limitations and Future Research Directions

    The interpretation of the findings is limited by the small GLP-1RA cohort (n = 12), baseline imbalances in BMI and sex, the single-center retrospective design, incomplete autoantibody testing, and a median follow-up of approximately eight months. Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity.

    Journal reference:

    • Tejeji I., Zeier T., Smith J. A., Chang N. T., Chao L. C. (2025). Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study. Journal of Pediatric Endocrinology and Metabolism. DOI: 10.1515/jpem-2025-0493, https://www.degruyterbrill.com/document/doi/10.1515/jpem-2025-0493/html

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  • New ‘Lucifer’ bee with devil-like horns found in Australia

    New ‘Lucifer’ bee with devil-like horns found in Australia

    Australian scientists have discovered a new native bee species with tiny horns – and given it a suitably devilish name.

    Researchers found the Megachile Lucifer while observing a rare wildflower that only grows in the Bremer Ranges in Western…

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