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  • ASUS VivoWatch ECG App Receives FDA Thailand Certification

    ASUS VivoWatch ECG App Receives FDA Thailand Certification

    TAIPEI, Taiwan, July 1, 2025 ASUS today announced that the VivoWatch ECG app has been certified by the Food and Drug Administration Thailand (FDA Thai). A major advancement for smart healthcare innovation in Thailand, certification for the ECG software marks a milestone for ASUS, underscoring its expanding role in the global digital health landscape and its commitment to medical-grade technology innovation.  

    ʺOur goal is to empower individuals and healthcare providers with the best health monitoring tools,ʺ said Joe Hsieh, COO and Global Senior Vice President of ASUS. ʺThis certification validates our technology and also reinforces the ASUS commitment to expanding global access to smart, medical-grade health solutions.ʺ  

    Intuitive and efficient monitoring 

    With the new ECG app, users can measure their ECG readings directly via ASUS VivoWatch. To take a measurement, the user places a fingertip on the watchface sensors for 30 seconds. It will display the results and even allow users to easily share them with their healthcare provider. Compatible ASUS VivoWatch models include the latest ASUS VivoWatch 6 and ASUS VivoWatch 6 AERO 

     

    Ready for personal and institutional use 

    The ECG functionality enabled by ASUS VivoWatch is ideal for individual consumers as well as for use in hospitals, clinics and any other healthcare setting. It can also be integrated into business-to-business (B2B) solutions to enhance VIP patient care and support premium health management services.  

    In addition to the newly activated ECG function, ASUS VivoWatch also supports blood pressure monitoring. This means that VivoWatch enables users to track two essential cardiovascular indicators simultaneously. With accurate, real-time date, the solution helps detect potential health issues, making it a valuable asset for institutions aiming to improve both care quality and operational efficiency.    

    ECG feature available now 

    To enjoy the benefits of the accurate ECG feature today, users simply need to update both the ASUS HealthConnect app and the ASUS VivoWatch software.   

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  • How Gir lions are using scent to communicate

    How Gir lions are using scent to communicate

    • A two-year study has mapped behavioural patterns and scent-marking preferences among India’s last wild lions, offering rare insights into how they communicate.
    • Among all observed behaviours, sniffing was the most common, accounting for nearly 40% of the recorded actions. This was followed by scratching and spraying.
    • As Gir’s lion population grows, knowing where and how they mark territory can guide conservation practices, from protecting key habitats and movement corridors to planning for coexistence in shared landscapes.

    Mammals, most prominently carnivorous species, use scent-marking as a crucial form of communication. Lions, for example, use urine, faeces, and secretions from scent glands to leave behind long-lasting chemical signals on trees and trails. While these are invisible to the human eye, they carry a meaning for other lions in that area.

    A study conducted in Gujarat’s Gir Forest focussed on decoding some of this hidden communication. “This is the first detailed scientific study of scent-marking in free-ranging Asiatic lions, and it reveals how scent is a powerful tool for territory defence, mate attraction, and social interaction,” says Mohan Ram, Divisional Forest Officer, Wildlife Division, Sasan-Gir, Gir National Park and Sanctuary, and one of the lead researchers.

    Leaving a mark

    Gir Forest, which includes a national park and sanctuary, is spread across nearly 1,900 square kilometres in Gujarat’s Saurashtra region. It is home to over 40 species of mammals, including leopards, hyenas, and jackals, but the lion is its undisputed icon. To understand how the big cats use scent to communicate, researchers collaborated with Gir’s seasoned field trackers. These experts helped identify trees that showed signs of regular scratching and are favoured spots for lion scent-marking.

    At 36 such locations, the team installed motion-triggered infrared cameras between March 2022 and April 2024. “Across three seasons, we faced all kinds of challenges, from sensor triggers caused by birds or wind to monsoon rains that washed away scent marks. Reaching camera trap locations during heavy rain was a task in itself. Plus, the volume of data collected was enormous, and it took a lot of effort to sift through and sort out usable footage,” says Ram.

    Each time a lion passed by the cameras captured a short video and a photograph. In total, they logged over 15,000 wildlife detections, of which 1,542 featured lions. Every lion video was carefully analysed for specific behaviours such as sniffing, scratching, spraying, rubbing, and even climbing. “Camera trapping helped us capture behaviour without disturbing the lions. We also kept the camera settings standard across sites and seasons to ensure consistency,” says Ram.

    Researchers also documented tree characteristics such as species, height, girth, and proximity to roads or water to understand what made certain trees more likely to be used as scent posts.

    The data was then grouped by season, time of day, the lion’s age and sex, and the traits of the marked trees. Using statistical tools, the team mapped out behavioural patterns and scent-marking preferences across the Gir landscape.

    Marking scent part of daily routine

    Among all observed behaviours, sniffing was the most common, accounting for nearly 40% of the recorded actions. This was followed by scratching (30%) and spraying (12%). Young lions were more likely to climb trees, possibly as playful behaviour or a way of learning.

    Males were the more active scent-markers, often around pride territories. Females also left their mark, especially when they were in heat. “It’s a key part of territorial and reproductive strategy in a species with such a limited geographic range. Sub-adults were also seen using the same trees repeatedly, almost like they were learning how to mark territory,” says Ram.

    Young lions were more likely to climb trees, possibly as playful behaviour or a way of learning, according to a study on Gir lions. Image by Mohan Ram.

    Most of these behaviours occurred in the early morning hours, with scratching and spraying peaking at 3:44 a.m. and 4:17 a.m. respectively. This pattern suggests that scent-marking is a deliberate and well-timed part of the lions’ daily routines.

    Winter turned out to be the busiest season for scent-marking. This aligns with the peak of lion mating season, highlighting the link between chemical communication and reproduction.
    “Cooler temperatures meant more lion movement, which led to more marking. Interestingly, lions often chose tilted trees (around 45 degrees) because the spray lands better and holds fragrance longer, especially in the monsoon,” says Ram.

    Identifying a good marking spot

    Lions also didn’t mark trees at random. They showed clear preferences for certain species, especially Butea monosperma and Syzygium cumini. “We noticed that the lions preferred trees with soft bark or gum, species with strong secondary metabolites, likely because the scent tends to linger longer. Teak trees were avoided; the bark is too hard to claw,” says Ram.

    Location played a key role too. Most of the marked trees were near forest trails and water sources. Trails serve as lion highways, ideal places to advertise presence to rivals or potential mates. “The preferred trees were often near trails, indicating lions may be aligning marking behaviour with movement corridors, possibly even taking human presence into account,” explains Ram.

    Moist environments may also help preserve chemical signals for longer durations. Scrub habitats, in particular, recorded more scent-marking activity. Their open structure likely makes scent-posts more visible and accessible.

    Female lions left scent marks, especially when they were in heat. Image by Mohan Ram.
    Female lions left scent marks, especially when they were in heat, noted the study. Image by Mohan Ram.

    Why studying behaviour matters

    Asiatic lions differ from their African counterparts in many ways. They live in smaller groups, don’t breed in synchrony, and are confined to a single, limited landscape in western India. These unique conditions shape how they interact, compete, and survive.

    By identifying where and when scent-marking takes place, this study offers valuable insights into lion behaviour. The findings can help conservationists refine strategies for habitat protection, water management, boundary marking, and lion monitoring ensuring the continued survival of India’s last wild lions. “Knowing which tree species lions prefer can guide habitat improvement efforts. It can even help prevent poaching by identifying high-use marking spots,” says Ram.

    The researchers recommend that future studies combine scent-marking data with GPS collaring to track individual lions over time. This approach could reveal more details such as whether specific lions favour particular trees, and how their marking behaviours shift with seasons, age, or social status. All these insights could be particularly valuable as the lion population eventually grows and begins expanding into Gir’s neighbouring areas. “It can directly inform habitat planning beyond Gir, and support strategies for lion movement and coexistence with local communities,” Ram says.


    Read more: Asiatic lion population has grown 172% in 25 years


     

    Banner image: A study found that among all observed behaviours of Gir lions, sniffing was the most common, accounting for nearly 40% of the recorded actions. Image by Mohan Ram.




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  • We have given everything, says Guardiola – Manchester City FC

    1. We have given everything, says Guardiola  Manchester City FC
    2. Pep Guardiola issues heartfelt thank you to Manchester City for crucial Club World Cup decision  City Xtra
    3. WATCH: Stunning beach yoga drone shots  Manchester City FC
    4. VIDEO: Shirtless Pep Guardiola joins Man City squad in game of ‘two touch’ during beach recovery session as fans hail manager as ‘new signing’  Goal.com
    5. Guardiola allows players free rein at the Club World Cup  MSN

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  • Fresh Produce | DT Swiss D 1900 DJ Wheelset

    Fresh Produce | DT Swiss D 1900 DJ Wheelset

    It’s not just high-end watches and world-class chocolate that come out of Switzerland; the last 30 years have taught us that the Swiss are pretty darn good at making bike wheels too. DT Swiss has become one of the leading manufacturers of all things related to bike wheels, and, learning from its watch-making brothers and sisters, has ventured into the intricate realm of developing and manufacturing suspension.

    In the brand’s lineup is a wheel for almost every discipline of cycling, including the D 1900 wheelset seen here, designed specifically for the demands of dirt jumpers and pump-track riders alike. The theme tune for this wheelset sings reliability and durability, ready to case that gap you’ve been eyeing up at the pump-track or under-rotate that 360° you’ve been trying to nail.

    Stealth black and ready for a beating, the D 1900’s are destined for the dirt-jumps or the pump-track.

    Related:

    DT Swiss D 1900 Wheelset

    Starting from the inside, the D 1900 wheels spin on a pair of DT Swiss 370 hubs, but these aren’t the same as what you’d find on a trail bike. The front hub comes in a Boost 110mm width, and includes end caps for both 15mm and 20mm axles, however has no provisions for a front disc brake. Generally speaking, a lot of folk only run a single rear brake on dirt-jump or pump track bikes for simplicity and to reduce the number of cables, hence the move by DT Swiss to eliminate the front brake mount from the hub.

    In the rear, we have another DT Swiss 370 hub, but this time configured for a 135mm axle spacing and in a bolt-up configuration. This will suit the majority of hardtail DJ frames with sliding dropouts on the market, and allows for simple adjustments to chain tension. The hub comes preconfigured with a singlespeed specific freehub inbuilt with a 12T cog, and runs the DT Swiss Ratchet LN36 internals. This is the brand’s 3-pawl system with 36 engagement points, and is well known for being extremely durable and easily rebuildable.

    Key Details

    • Wheel Size | 26in Only
    • Hub Spacing | 110x20mm Front (15mm adapters included), 135mm Bolt-Up Rear
    • Disc Mounting | No Brake Interface Front, 6-Bolt Rear
    • Freehub | Singlespeed w/12T Cog, Ratchet LN36 internals
    • Rim Material | Aluminium
    • Rim Width | 30mm Internal
    • Spoke Count | 32H
    • Wheelset Price | $250 AUD Front, $360 AUD Rear
    • Hub Only Price | $159 AUD Front, $299 AUD Rear
    • Wheelset Weight | 1,060g Front, 1,294g Rear, 2,354g Total (Claimed)

    Spokes are taken care of by DT Swiss’s own double-butted Competition spokes configured in a traditional 3-cross lacing pattern, and secured to the rim via Brass ProLock Squorx nipples.

    And to finish things off, a sturdy aluminium, pin-joint rim with a 30mm internal width keeps the D 1900’s rolling. They come pre-wrapped in tubeless tape, but can be run with tubes if preferred. It’s worth noting that the D 1900 wheelset does carry a maximum recommended rider weight of 120kg to be able to handle the trashing they are built for. These are available only in 26in to suit the majority of dirt jump bikes available on the market.

    As for price, the wheels are sold individually, with the front retailing for $250 AUD and the rear for $360 AUD. The DJ-specific 370 hubs will be available separately for $159 AUD and $299 AUD for the front and rear, respectively. Given the small price difference, the complete wheelset appears far better value than buying the hubs alone and building the wheels from scratch. However for those just chasing hubs, it’s excellent to see this as an option nevertheless.

    We fitted the D 1900 hoops to a Canyon Stitched 360, which were a direct swap for the stock wheels. Following a fair share of heavy landings, they’ve stayed true and haven’t had any detensioning issues.

    Aside from that, there’s not a whole lot to be said. We were a little surprised that DT didn’t choose the EX471 rim for the wheel build, as this is the rim of choice for many elite DJ riders. This likely would have pushed the price a bit higher though, and as it stands this is a great value wheelset.

    The D1900’s have been plenty sturdy so far, surviving more than a few under-rotations and cases.

    Of course they’re not super-light at 2.35kg for the pair, and the ride quality was similar to the stock wheelset. With weight not being the drawcard, durability and cost becomes the primary selling point of the D 1900s. The pre-built wheelset options in this space are few and far between, forcing a lot of riders to opt for custom-built wheels. These generally carry significantly higher price tags once you factor in the labour to build the wheels. This makes the D 1900s an attractive choice as a replacement upgrade for your DJ bike’s stock wheels once they look like tacos.


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  • Shefali Jariwala death: Cardiologist explains steroids, drug overdose, hormonal therapy can increase heart attack risk | Health

    Shefali Jariwala death: Cardiologist explains steroids, drug overdose, hormonal therapy can increase heart attack risk | Health

    Actor and model Shefali Jariwala’s death at 42 on June 27 is sparking concerns about the potential risks of anti-aging treatments. According to reports, she received an anti-ageing injection containing glutathione and vitamin C on an empty stomach, which may have led to a sudden drop in blood pressure, resulting in cardiac arrest. Shefali was known for her appearance in Bigg Boss 13 and the 2002 music video, Kaanta Laga. Also read | Cardiologist calls ‘heart attacks in women deadlier’; 6 lifestyle changes to make today

    Shefali Jariwala died on Friday at the age of 42. Now a doctor has shared how steroids, drug overdoses, and hormonal therapies for women, as well as oral contraceptives, can contribute to heart attack risk. (Instagram/ Shefali Jariwala)

    What can contribute to heart attack risk?

    Dr Dhirendra Singhania, principal consultant of interventional cardiology at Yashoda Super Speciality Hospitals in Kaushambi, said in June 30 interview with NDTV that the ‘major causes of risk in heart attacks are steroids, lack of sleep, and hormonal therapies, especially for women’.

    He said, “Everyone, whether a celebrity or a common man, if they are not following the rules of the body, they will have problems. In celebrities, they all try to maintain their body for fit appearances. Many times, we don’t know what they do to achieve that. Lack of sleep has been known as a cardiac risk factor – many celebrities are awake for almost the whole night at times.”

    Highlighting the importance of approaching anti-ageing treatments with caution, and prioritising your health and safety, Dr Singhania added, “Steroids, drug overdoses, and hormonal therapies for women, such as hormone replacement therapy (HRT for menopause) and oral contraceptives, can contribute to heart attack risk.”

    Be cautious with anti-ageing treatments

    Before trying any anti-ageing treatments, it’s essential to consult a qualified doctor, especially if you have heart conditions or other health issues. In a May 2025 interview with HT Lifestyle, a dermatologist explained non-invasive skin treatments, the ideal age to start them, signs of ageing, and who should avoid these treatments in a complete guide. Click here to know what she said.

    Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

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  • A gripping look at rugby, politics, and unity » allblacks.com

    A gripping look at rugby, politics, and unity » allblacks.com

    As the All Blacks gear up for the Lipovitan-D July series against France, NZR+ invites fans to step back in time and experience one of the most powerful chapters in New Zealand rugby history with the acclaimed documentary By the Balls.

    Told through the voices of those who lived it – legends like David Kirk, Buck Shelford, John Kirwan, and Grant Fox – By the Balls is more than a sports story. It’s a raw, personal account of a turbulent era when rugby collided head-on with politics, and where teammates were divided by principle, protest, and national expectation.

    From the controversial 1986 Cavaliers tour to the groundbreaking victory in the inaugural 1987 Rugby World Cup against arch rivals France, the documentary uncovers the personal toll of the era’s intense political climate — from tensions on the field and public backlash off it, to deep divisions within the All Blacks camp. Kirk’s reflections on being ostracised by some teammates and Shelford’s unflinching honesty about his decision to tour South Africa offer rare insight into the emotional weight behind the game.

    Loaded with unforgettable moments—from gritty match footage to candid interviews – the film paints a vivid portrait of a time when the future of New Zealand rugby, and its moral compass, hung in the balance.

    By the Balls is essential viewing – not just for rugby fans, but for anyone interested in how sport can challenge, fracture, and ultimately help heal a nation.

    Now streaming on NZR+. Don’t miss it.


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  • Israel bombs Gaza aid sites, cafe and school, killing 95 Palestinians | Gaza News

    Israel bombs Gaza aid sites, cafe and school, killing 95 Palestinians | Gaza News

    Israeli forces have bombed a cafe, a school and food distribution sites in Gaza, killing at least 95 Palestinians, and attacked a hospital, wounding several more people.

    At least 62 of the victims of Monday’s attacks were in Gaza City and the north of the territory.

    The figure includes 39 people who were killed in an Israeli strike on a seaside cafe, Al-Baqa cafeteria, in northern Gaza City. Dozens more were wounded.

    Among the dead was journalist Ismail Abu Hatab, as well as women and children who had gathered at the cafe.

    One witness said that Israeli fighter jets carried out the strike.

    “We found people torn apart,” said Yahya Sharif. “This place wasn’t affiliated with anyone – no politics and no military association whatsoever. It was packed with people including children for a birthday party.”

    The bombing flattened the cafe and left a huge crater in the ground.

    Al Jazeera’s Hani Mahmoud, reporting from Gaza City, said the attack on the cafe occurred “without any warning”.

    “This area serves as a refuge for many traumatised and displaced people, offering some relief from the oppressive heat of the tents. The bloodstains are still everywhere given the intensity of the explosion. Some of the bodies and pieces of flesh were collected from the flood of this place,” he added.

    Also on Monday, Israeli forces carried out an air strike on a food distribution warehouse in the Zeitoun neighbourhood of Gaza City, killing at least 13 people who were trying to get rations.

    The Israeli military also bombed the Yafa school in Gaza City, which was sheltering hundreds of displaced Palestinians.

    Hamada Abu Jaradeh, who fled before the attack, said that displaced Palestinians received a five-minute threat to evacuate. “We don’t know what to do and where to go. We have been let down by the entire world for more than 630 days. Death is with us and around us every day,” Abu Jaradeh said.

    In central Gaza, Israeli forces attacked the courtyard of Al-Aqsa Hospital in Deir el-Balah, where thousands of families had sought shelter.

    Videos circulating online and verified by Al Jazeera showed chaos at the hospital, with people fleeing for safety as tents sheltering displaced families appeared damaged by the attack.

    Al Jazeera’s Tareq Abu Azzoum, reporting from the scene of the hospital attack, said the army did not issue “any warnings” before the “huge explosion”.

    “The site of the attack is about 10 metres [33 ft] from our broadcast point. This is not the first time the hospital’s courtyard has been attacked. At least 10 times, this facility has been squarely targeted by Israeli forces,” Abu Azzoum said. “It’s a staggering concentration of attacks on medical facilities, adding further burden on barely functioning hospitals.”

    In a statement, Gaza’s Government Media Office decried the attack by Israel, calling it a “systematic crime” against the Palestinian enclave’s health system.

    “Its warplanes bombed a tent for the displaced inside the walls of Al-Aqsa Martyrs Hospital, resulting in injuries at the site of the bombing, material damage and directly threatening the lives of dozens of patients,” it said.

    Israel has repeatedly targeted dozens of hospitals during its 22-month war on Gaza. Human rights groups and United Nations-backed experts have accused Israel of systematically destroying the enclave’s healthcare system.

    ‘It felt like earthquakes’

    In southern Gaza, an Israel air attack killed at least 15 Palestinians waiting for food at aid distribution hubs run by the controversial United States- and Israeli-backed Gaza Humanitarian Foundation (GHF) in Khan Younis, according to sources at Nasser Medical Complex.

    Fifty people were also wounded in the attack.

    They are the latest victims in a wave of daily carnage at these sites, which have killed nearly 600 Palestinians since GHF took over limited aid deliveries in Gaza in late May amid a crippling Israeli blockade.

    The Israeli military acknowledged on Monday that Palestinian civilians were harmed at the aid distribution centres, saying that instructions had been issued to forces following “lessons learned”, and that firing incidents were under review.

    This follows the Israeli news outlet Haaretz report that soldiers operating near the aid sites in Gaza have been deliberately firing on Palestinians. According to the Haaretz report, which quoted unnamed Israeli soldiers, troops were told to fire at the crowds of Palestinians and use unnecessary lethal force against people who appeared to pose no threat.

    Israeli forces are also carrying out home demolitions in Khan Younis, raising fears of a new ground invasion.

    The Israeli military, meanwhile, has issued more forced evacuation threats to Palestinians in large districts in northern Gaza, where Israeli forces had operated before and left behind wide-scale destruction, forcing a new wave of displacement.

    “Explosions never stopped; they bombed schools and homes. It felt like earthquakes,” said Salah, 60, a father of five children, from Gaza City. “In the news, we hear a ceasefire is near. On the ground, we see death and we hear explosions.”

    Israeli tanks pushed into the eastern areas of the Zeitoun suburb in Gaza City and shelled several areas in the north, while aircraft bombed at least four schools after ordering hundreds of families sheltering inside to leave, residents said.

    Gaza’s health authorities said that at least 10 people were killed in attacks on Zeitoun and at least 13 were killed southwest of Gaza City.

    More than 80 percent of Gaza is now an Israeli-militarised zone or under forced displacement threats, according to the United Nations.

    The attacks come as Israeli officials, including Israel’s strategic affairs minister, Ron Dermer, were due in Washington, DC for a new ceasefire push by the administration of US President Donald Trump.

    Key mediator Qatar has confirmed that there are serious US intentions to push for a return to negotiations, but there are complications, according to a Qatari Ministry of Foreign Affairs spokesman.

    “The main obstacle over here is that both parties aren’t coming back to the table. But as I have said, there’s a momentum that’s been created by the ceasefire between Iran and Israel,” Majed Al Ansari told reporters in the Qatari capital Doha.

    “We won’t hold out breath for this to happen today or tomorrow. But we believe that the elements are in place to push forward towards restarting the talks,” he added.

    The talks in the White House are also expected to cover Iran and possible wider regional diplomatic deals.

    In Israel, Prime Minister Benjamin Netanyahu’s Security Cabinet was expected to convene to discuss the next steps in Gaza.

    On Friday, Israel’s military chief said that the present ground operation was close to having achieved its goals, and on Sunday, Netanyahu claimed new opportunities had opened up for recovering the captives taken by Hamas and other Palestinian armed groups from Israel, 20 of whom are believed to still be alive.

    Palestinian and Egyptian sources with knowledge of the latest ceasefire efforts also said that mediators Qatar and Egypt have stepped up their contacts with the two sides, but that no date has been set yet for a new round of truce talks.

    Meanwhile, senior Hamas official Osama Hamdan said in a statement on Monday that there has been no news from Israel regarding a ceasefire for four weeks.

    “We are determined to seek a ceasefire that will save our people, and we are working with mediators to open the crossings,” Hamdan said.

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  • Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

    Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

    A new study from UCLA Health has uncovered how inflammation in brain blood vessels exacerbates damage in vascular dementia and demonstrated that targeting this process with a repurposed drug can promote brain repair and functional recovery in mice.

    Published in Cell, the research combines laboratory and human data to pinpoint a critical signaling pathway that could lead to the first effective treatment for this understudied form of dementia.

    Vascular dementia is the second leading cause of dementia. This disease co-occurs with Alzheimer’s disease in the leading cause of dementia, termed “mixed dementia.” There is no drug therapy that promotes recovery in vascular dementia. A key problem in this disease is that the brain damage expands from initial areas, to become larger over time. The UCLA team sought to identify what happens in the brain in these areas of expansion. To do this, the researchers identified all the molecules that communicate among the cells of the brain adjacent to the dementia lesions, and which ones are abnormally up or down in the disease compared to normal brain. By doing this both in laboratory models of vascular dementia and in human brain, the UCLA team was able to precisely identify the “interactome” in vascular dementia – all the molecules that signal or interact in the cells at risk.

    We reasoned that the cell in the brain areas in which the disease expands will lose their normal signaling with each other. In other words, the cell-to-cell interaction is disturbed in a toxic way in vascular dementia. We set out to identify these cell-to-cell interactions or the “interactome” in vascular dementia.” 


    Dr. S. Thomas Carmichael, study’s lead author and professor and chair Neurology at the David Geffen School of Medicine at UCLA

    One molecular system jumped out as potentially significant. This system communicates between blood vessel cells and adjacent brain inflammatory cells, termed microglia. In vascular dementia, the CD39 (an enzyme) and the adenosine A3 receptor (A3AR) are downregulated together in these two cell types, synergistically by aging and vessel ischemic lesion. Because vascular dementia is a disease of aging, this double finding – a downregulation with both disease and aging – signaled a possibly significant role. CD39 generates through several steps the molecule adenosine, which binds to A3AR, and modifies inflammation, downregulating some of its harmful effects. 

    To test this CD39/A3AR system as a possible drug target for treating vascular dementia, the group utilized a drug that is in clinical trials for psoriasis. When given to mice in a model of vascular dementia, this drug promoted repair of brain tissue and recovery of memory and gait functions.

    “The most exciting finding was that delayed intervention still worked,” said lead author Dr. Min Tian, a postdoctoral scholar at UCLA Health. “This is crucial because vascular dementia is often diagnosed late. By targeting the crosstalk between blood vessels and brain cells, we’re addressing the root cause of damage, not just masking symptoms.”

    While the results are promising, further studies are needed before human trials can begin. The team is now optimizing dosing and exploring biomarkers to track the therapy’s effectiveness.

    The study, “Deconstructing the Intercellular Interactome in Vascular Dementia with Focal Ischemia for Therapeutic Applications,” will be online in Cell, June 30, 2025, and includes collaborators from UCLA’s neurology, pathology, neurobiology, physiology and psychiatry departments. Funding was provided by the National Institutes of Health, Ressler Family Foundation, The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, including support from the Steffy Family Trust.

    Source:

    University of California – Los Angeles Health Sciences

    Journal reference:

    Tian, M., et al. (2025). Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications. Cell. doi.org/10.1016/j.cell.2025.06.002.

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  • Tony Hawk On Tony Hawk’s Pro Skater 3 + 4 Release: ‘The Nostalgia Is Obvious’

    Tony Hawk On Tony Hawk’s Pro Skater 3 + 4 Release: ‘The Nostalgia Is Obvious’

    For everyone who is looking to relive their childhood, Tony Hawk’s Pro Skater 3 + 4 will be re-released.

    The legendary games will be released on major consoles on July 11, marking the second time that Hawk’s games have been re-released in this current generation. Tony Hawk’s Pro Skater 1 + 2 was re-released in 2020 and 2021 on the current generation of consoles.

    “The nostalgia is obvious, and with our game coming out, the nostalgia for that is very strong,” says Hawk in a one-on-one interview.

    Tony Hawk’s Pro Skater is one of the most iconic video game franchises of all time. The first game was released in 1999 at a time when extreme sports was just starting to become a mainstream genre. The game’s release came just months after Hawk landed the first-ever 900 at X Games V.

    The original series generated over $1.4 billion in sales, with Tony Hawk’s Pro Skater 2 being the best-selling game of the franchise with over two million copies in the United States alone.

    The new edition will feature all of the notable skaters from the original games — Bucky Lasek, Bob Burnquist, Chad Muska and Hawk himself — along with multiple new current skaters. The game will also feature skateboard legend Bam Margera, something that Hawk had to push tremendously for. Margera will be included as a secret skater in the re-release of the game.

    While the game is very true to the original versions — Tony Hawk’s Pro Skater 3 and 4 were released in 2001 and 2002 — Hawk mentions that the re-release will feature new added elements, including new maps and levels.

    “Based on the success of our last remaster (1+2), I think it’ll be great,” says Hawk of the game’s re-release. “This one is more of a remake. We have some of the iconic levels from three and four, I think the ones that people most identify with. We also added some new maps and new levels, which I wanted to do.”

    There will be several new skaters added to the original lineup, including Chloe Covell — youngest women’s street gold medalist in X Games history — Rayssa Neal, Yuto Horigome, Jamie Foy and Zion Wright. There’s a number of new international skaters in the game, which represents the growing popularity of extreme sports across the world.

    Foy is considered the “best street skater” these days, according to Hawk. Meanwhile, Hawk calls the 26-year-old Wright a “machine.” The game will also feature new songs, with Hawk saying he didn’t want to repeat the old soundtrack. He also cites wanting to bring songs that resonates with the current generation.

    “I’m excited to venture into new territory and give people a chance to skate and do combos in different areas in new areas,” says Hawk. “We’ve updated the skaters so they reflect the current roster of the people you see either competing or in Thrasher Magazine, while still honoring the original characters.”

    Skateboarding debuted at the Olympics in 2020 and Hawk points towards that as a major reason for the international growth of the sport.

    “With the Olympics inclusion, that has helped to open eyes to skating in other countries that maybe hadn’t embraced it or considered it before,” says Hawk. “I feel like the international growth is even bigger. If you look at the top competitors now, so many are from Japan, from Australia, from Brazil, and that element is growing.”

    A total of 80 skateboarders participated in the 2020 Summer Olympics from 25 different countries. Japan won the most medals (five, three gold) with Brazil pulling in three total medals. Tony Hawk’s Pro Skater 3 + 4 features Horigome (who won gold in the men’s street competition) and Brazilian skater Rayssa Leal, who won silver in the women’s street competition.

    “Obviously, the United States is still doing well, but I feel like it has become much more international,” says Hawk. “I’m thankful for that, because it gives kids a chance to try it wherever they are.”

    Tony Hawk Partnering With Tony The Tiger For Tony Hawk’s Pro Skater 3 + 4

    In collaboration with the re-release of Tony Hawk’s Pro Skater 3 + 4, Hawk is partnering with an old friend of his — none other than popular cereal character Tony The Tiger. For those that aren’t familiar, Hawk was Tony The Tiger’s stunt double in 1990 for a commercial.

    “I’ve been a fan of Kellogg’s Frosted Flakes since I could choose my own breakfast,” says Hawk. “But I got to work on a commercial in 1990 where I was the stunt double for Tony The Tiger. It’s the early days of animating things over actual video. It was a little archaic, but I think it looked great. I had to wear a skin tight suit.”

    While Hawk is a mega star and has been over the past quarter century, that wasn’t the case in the early 90’s. This preceded the debut of the X Games and Hawk hitting the innovative 900 move. It also preceded the release of his popular video game series by nearly a decade.

    The 57-year-old says he was just thankful to get work at that time, considering vert skaters didn’t receive much recognition in the early 90’s.

    “My friend Chris Miller was the main character in the commercial, so I ended up filming him as well,” Hawk details. “I was the cameraman, and I was Tony The Tiger in that commercial. At the time, there weren’t a lot of opportunities for skateboarders, especially vertical half-pipe skateboarders, so I was thankful to get a job, to be honest.”

    The two Tony’s will be teaming up again at the Vert Alert Legends Demo in Salt Lake City, Utah.

    “Here we are 35 years later, and we’ve incorporated Tony the Tiger into the game with some of the merch,” says Hawk. “I got to hang out with him on my ramp a couple weeks ago, and he is coming to our big event in Salt Lake City, the Vert Alert on July 18 and 19th. He’ll actually be there in person. It’s beyond any dream I would have had, because I didn’t imagine I’d even get to be a pro skater into my old age.”

    Limited edition skateboards will be released to five fans, including autographed merchandise at the Vert Alert Legends Demo.

    “To bring those two elements together for me is an amazing collaboration,” says Hawk of teaming up with Tony The Tiger again. “We’ll be doing some giveaways with some prize packs, Tony the Tiger skateboards, limited edition Frosted Flakes boxes. I’m doing some social media stuff with Tony. It’s a meeting of the Tonys, which has been pretty cool. We actually created our own handshake.”

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  • AI tool matches doctors in accurately outlining lung tumors on CT scans

    AI tool matches doctors in accurately outlining lung tumors on CT scans

    In radiation therapy, precision can save lives. Oncologists must carefully map the size and location of a tumor before delivering high-dose radiation to destroy cancer cells while sparing healthy tissue. But this process, called tumor segmentation, is still done manually, takes time, varies between doctors – and can lead to critical tumor areas being overlooked.

    Now, a team of Northwestern Medicine scientists has developed an AI tool called iSeg that not only matches doctors in accurately outlining lung tumors on CT scans but can also identify areas that some doctors may miss, reports a large new study.

    Unlike earlier AI tools that focused on static images, iSeg is the first 3D deep learning tool shown to segment tumors as they move with each breath – a critical factor in planning radiation treatment, which half of all cancer patients in the U.S. receive during their illness.

    We’re one step closer to cancer treatments that are even more precise than any of us imagined just a decade ago.”


    Dr. Mohamed Abazeed, senior author, chair and professor of radiation oncology at Northwestern University Feinberg School of Medicine

    “The goal of this technology is to give our doctors better tools,” added Abazeed, who leads a research team developing data-driven tools to personalize and improve cancer treatment and is a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

    The study will be published June 30 in the journal npj Precision Oncology.

    How iSeg was built and tested

    The Northwestern scientists trained iSeg using CT scans and doctor-drawn tumor outlines from hundreds of lung cancer patients treated at nine clinics within the Northwestern Medicine and Cleveland Clinic health systems. That’s far beyond the small, single-hospital datasets used in many past studies.

    After training, the AI was tested on patient scans it hadn’t seen before. Its tumor outlines were then compared to those drawn by physicians. The study found that iSeg consistently matched expert outlines across hospitals and scan types. It also flagged additional areas that some doctors missed – and those missed areas were linked to worse outcomes if left untreated. This suggests iSeg may help catch high-risk regions that often go unnoticed.

    “Accurate tumor targeting is the foundation of safe and effective radiation therapy, where even small errors in targeting can impact tumor control or cause unnecessary toxicity,” Abazeed said.

    “By automating and standardizing tumor contouring, our AI tool can help reduce delays, ensure fairness across hospitals and potentially identify areas that doctors might miss – ultimately improving patient care and clinical outcomes,” added first author Sagnik Sarkar, a senior research technologist at Feinberg who holds a Master of Science in artificial intelligence from Northwestern.

    Clinical deployment possible ‘within a couple years’

    The research team is now testing iSeg in clinical settings, comparing its performance to physicians in real time. They are also integrating features like user feedback and working to expand the technology to other tumor types, such as liver, brain and prostate cancers. The team also plans to adapt iSeg to other imaging methods, including MRI and PET scans.

    “We envision this as a foundational tool that could standardize and enhance how tumors are targeted in radiation oncology, especially in settings where access to subspecialty expertise is limited,” said co- author Troy Teo, instructor of radiation oncology at Feinberg.

    “This technology can help support more consistent care across institutions, and we believe clinical deployment could be possible within a couple of years,” Teo added.

    This study is titled “Deep learning for automated, motion- resolved tumor segmentation in radiotherapy.”

    Source:

    Journal reference:

    Sarkar, S., et al. (2025). Deep learning for automated, motion-resolved tumor segmentation in radiotherapy. npj Precision Oncology. doi.org/10.1038/s41698-025-00970-1.

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