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  • Protecting Mental Health and Preventing Burnout in Health and Care Workers

    Protecting Mental Health and Preventing Burnout in Health and Care Workers

    The fifth in this year’s Working for Health 2030 webinar series co-hosted by WHO and NHS England, this seminar examines the prevalence of mental health issues and burnout among health and care workers, focusing on organisational and systemic drivers. We will explore how employers and health systems can address these issues and prioritise staff well-being, leading to improved retention and productivity. The discussion, led by Shriti Pattani National Clinical Expert in Occupational Health and Wellbeing for NHS England and the Clinical Director, Consultant in Occupational Medicine and Head of Service of an Occupational Health and Wellbeing service for a large Acute Trust in London, will include:

    ✅ What burnout looks like — and why health and care workers are especially at risk
    ✅ Evidence-based interventions to support mental health and well-being
    ✅ How data and digital tools can help us tackle burnout
    ✅ Innovative, low-cost strategies to improve staff experience, well-being, retention and productivity

    Don’t miss this opportunity to reflect, engage, and be a part of the solution. Our duty of care begins with protecting those who care for us.

    Register now

    Additional informationNHS England

     

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  • Independent disciplinary process update: Randall Baker (New Zealand) and George Timmins (England) – World Rugby

    Independent disciplinary process update: Randall Baker (New Zealand) and George Timmins (England) – World Rugby

    1. Independent disciplinary process update: Randall Baker (New Zealand) and George Timmins (England)  World Rugby
    2. Independent disciplinary process update: George Timmins (England) and Randall Baker (New Zealand)  World Rugby
    3. England player ruled out of U20 Championship  Rugbypass.com
    4. England suffers big blow ahead of Baby Bok face-off  Rugby365

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  • Gut Bacteria Produce Sphingolipids To Protect Host

    Gut Bacteria Produce Sphingolipids To Protect Host

    The totality of bacteria, viruses and fungi that exist in and on a multicellular organism forms its natural microbiome. The interactions between the body and these microorganisms significantly influence both, the functions and health of the host organism. Researchers assume that the microbiome plays an important role in the defence against pathogens, among other things. The Collaborative Research Centre (CRC) 1182 “Origin and Function of Metaorganisms” at Kiel University has been investigating the highly complex interplay between host organisms and microorganisms for several years using various model organisms, including the nematode Caenorhabditis elegans.

    In a recent study, researchers from the CRC 1182 have gained new insights into the molecular mechanisms within the microbiome which contribute to the defence against pathogens. In collaboration with scientists from the Max Planck Institute for Terrestrial Microbiology and the University of Edinburgh, they discovered that a protective bacterium of the genus Pseudomonas, which is found in the intestinal microbiome of C. elegans, produces sphingolipids. This result was surprising, as it was previously assumed that the production of sphingolipids was restricted to only a few bacterial phyla and the bacterial genus Pseudomonas was not known to be able to produce these specific molecules. The researchers discovered that Pseudomonas utilises an alternative metabolic pathway for sphingolipid production, which differs significantly from the known sphingolipid synthesis pathways in other bacteria. They were also able to show that the sphingolipids produced by Pseudomonas bacteria play an essential role in protecting the intestinal epithelium of the host from damage by the pathogen.

    Responsible for sphingolipid production in Pseudomonas bacteria is a specific biosynthetic gene cluster that forms the enzymes for this novel metabolic pathway. Interestingly, similar gene clusters were also found in other host-associated gut bacteria, suggesting that the ability to produce sphingolipids may be more widespread than previously thought. This suggests that bacterial sphingolipids may play a central role in microbiome-mediated protection against infection – not only in C. elegans, but potentially also in other host organisms. The results of the interdisciplinary study, conducted under the leadership of PD Dr Katja Dierking (Evolutionary Ecology and Genetics research group at Kiel University), in collaboration with other research groups from Kiel and national and international cooperation partners, were recently published in the journal Nature Communications.

    Bacteria use alternative pathway to produce protective sphingolipids

    A few years ago, the Kiel research group had already published a study (Kissoyan et al. (2019), Current Biology) that showed that certain members of the C. elegans microbiota protect against pathogen infection.  “For one Pseudomonas species we knew that it can protect the worm from infections. However, we had not yet been able to identify the substances and mechanisms involved,” emphasises Dr Lena Peters, a scientist in the Evolutionary Ecology and Genetics research group.

    In a broad-based collaboration of scientists both within the CRC 1182 – including Kiel professors Christoph Kaleta and Manuel Liebeke – and with external scientists, including Professor Helge Bode from the MPI for Terrestrial Microbiology in Marburg and Professor Dominic Campopiano from the University of Edinburgh in Scotland, the genetic and metabolic basis of the protection against infection mediated by the microbiome was analyzed. Using metabolic and transcriptional studies, single molecule analyses and mass spectrometry approaches, the researchers made a surprising discovery: they were able to prove that the protective bacteria of the genus Pseudomonas produce sphingolipids that influence the worm’s sphingolipid metabolism and thus support the host’s protection against pathogens.

    “This finding is relatively new,” explains Peters, member of the CRC 1182, “normally, bacteria use the sphingolipid metabolism of host organisms to manipulate it in a targeted manner to promote infections. In our case, however, we observe the opposite – bacterial sphingolipids apparently actively support the protection of the host.” Sphingolipids are fat-like molecules that are typically found in eukaryotes, where they fulfil important structural and regulatory functions, but are rare in bacteria. In Pseudomonas, they are synthesised via a previously unknown, alternative metabolic pathway – not as a component of primary metabolism, as is usually the case, but as a so-called secondary metabolite.

    The researchers discovered that this previously unknown metabolic pathway is based on a specific biosynthetic gene cluster, a so-called polyketide synthase. “With our experiments, we were able to confirm that the worms survived better in the presence of Pseudomonas fluorescens bacteria possessing this gene cluster when they were infected with the pathogen Bacillus thuringiensis,” emphasises Peters, first author of the study. After identifying the responsible genes, the scientists could confirm through further analyses that the gene cluster encodes the enzymes required for sphingolipid synthesis. “It is exciting to be authors on this important, breakthrough paper. We are pleased that our expertise in bacterial sphingolipid research has helped discover a new role in the worm microbiome for these enigmatic lipids,” says Prof. Campopiano.

    “The protective mechanism against infections with B. thuringiensis apparently works indirectly. The lipids produced by Pseudomonas influence the worm’s sphingolipid metabolism, which presumably leads to an improved barrier function of the intestinal cells,” explains Peters. When the worm is infected with B. thuringiensis, the toxins of the pathogen create small pores in the cell membrane of the host, which makes it easier for the pathogens to penetrate. “We assume that the sphingolipid metabolism modified by P. fluorescens strengthens the stability and resistance of the cell membranes – and thus offers effective, indirect protection against pathogens,” Peters continues.

    “Overall, the new research work expands our understanding of how microbial metabolites support host defence against pathogens,” says Dierking, independent group leader in the Evolutionary Ecology and Genetics research group. In the long term, the researchers of the CRC 1182, who are also active in Kiel University’s priority research area Kiel Life Science (KLS), hope that better knowledge of such fundamental mechanisms will also make it possible to influence disorders of the human gut microbiome which may result in better treatment options for a variety of associated diseases.

    Reference: Peters L, Drechsler M, Herrera MA, et al. Polyketide synthase-derived sphingolipids mediate microbiota protection against a bacterial pathogen in C. elegans. Nat Commun. 2025;16(1):5151. doi: 10.1038/s41467-025-60234-1

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • The path to malaria elimination in Suriname – PAHO/WHO

    The path to malaria elimination in Suriname – PAHO/WHO

    Community-embedded healthcare: A critical strategy

    Given these factors, embedding healthcare workers directly within communities is crucial. Dijon Jullien, a healthcare assistant on Gakaba Island, a small community bordering Suriname and French Guiana, has witnessed the positive impact of the country’s primary healthcare service on local malaria reduction. “When individuals visit the clinic, they feel reassured that they will receive proper care. The health assistants are like sisters to the community, making it easy for everyone to discuss their health concerns openly,” she shared.

    From 2000 to 2005, Suriname faced a high malaria incidence, with about 160 reported cases per 1000 people. However, thanks to the country’s dedicated efforts – including universal access to diagnosis and treatment, an extensive network of community health workers, and nationwide malaria screening at border crossings – Suriname has successfully eliminated the disease.

    Photo credit: Rafael Jantz

    “Being malaria-free means that our population is no longer at risk from malaria and will also have positive effects on our healthcare sector, the economy and tourism,” said Dr. Amar Ramadhin, Suriname’s Minister of Health. “We are the first Amazonian country to be malaria-free, setting an example for other nations in the region that are still struggling with this disease.”

    PAHO has continued to collaborate with Suriname throughout the elimination process on the development of policies and programs to strengthen prevention, surveillance, and treatment.  With support from the US Government, PAHO has provided cooperation for the country’s anti-malaria campaign. In addition to support provide by the Global Fund since 2005, Suriname has also benefited from financing provided by the Inter-American Development Bank to tackle infectious diseases, including malaria.

    Communication materials on malaria prevention and treatment

    Photo credit: Coco Duivenvoorde

    Malaria is one of the diseases targeted by PAHO’s Disease Elimination Initiative, which aims to eliminate over 30 communicable diseases, including malaria, across the Americas by 2030. 

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  • Galaxy phone users should turn on these new anti-theft features ASAP, says Samsung

    Galaxy phone users should turn on these new anti-theft features ASAP, says Samsung

    Kerry Wan/ZDNET

    If you’re a Galaxy phone user, Samsung warns that you need to activate some new features as soon as you can.

    In a recent press release, Samsung explained that as phone thefts continue to rise around the world, it’s critical for users to make sure they enable their phone’s security measures – some of which are new to One UI 7.

    Also: Phone theft is on the rise – 7 ways to protect your device before it’s too late

    One of the areas getting an update is Theft Protection, which Samsung called “a multi-layered suite of features developed to safeguard personal data.” Existing and updated features in this suite include:

    • Theft Detection Lock: This feature uses machine learning to detect motions associated with theft (like a sudden snatch and rapid acceleration), and instantly locks the screen to stop unauthorized access. Pixel devices introduced a similar feature last fall.

    • Offline Device Lock: If your device is disconnected from the network for an extended time, the screen gets automatically locked.

    • Remote Lock: If your phone has already been stolen, you can lock it remotely using your phone number and a quick verification step. You can also regain control of your account and explore additional recovery options.

    These features build on the standard Android safety protection, Samsung noted, but take security a step further by introducing additional protection for high-risk scenarios when your access credentials have been compromised.

    To turn on these features, head to your device’s settings menu and find security and privacy, then “Lost Device Protection” and “Theft Protection.”

    Samsung also recommended enabling new anti-robbery features that were released in One UI 7, including: 

    • Identity check: Samsung lets you define trusted places (say, your home in Google Maps) where your phone stays unlocked. With the “Safe Places” feature, if you’re outside a trusted place, your phone will require biometric authentication for any sensitive security changes. This helps keep your device safe even if someone has your PIN.

    • Security Delay: If someone attempts to reset biometric data, your phone puts a one-hour waiting period in place. This gives users time to lock their stolen phone from another device before unauthorized access can occur.

    These features are also under the Security and Privacy Section of the settings menu, but under “Lost Device Protection.”

    Also: 5 warning signs that your phone’s been hacked – and how to fight back
    Samsung said the updated theft features are becoming available now on previous flagship devices like the Galaxy S24 series, Z Fold6, Z Flip6, Z Fold5, Z Flip 5, S23, and S22 series, with future updates coming to even more Galaxy smartphones.

    Features like this are starting to become commonplace. Android rolled out broader anti-theft measures last fall, added a few more in May, and even introduced some enhanced protections just a few days ago. Apple introduced its own version for iPhones last January.

    Get the morning’s top stories in your inbox each day with our Tech Today newsletter.


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  • Europe’s expanding heat wave fuels record temperatures, including in the Alps – The Washington Post

    1. Europe’s expanding heat wave fuels record temperatures, including in the Alps  The Washington Post
    2. ‘Unprecedented’ alerts in France as blistering heat grips Europe  BBC
    3. Europe heatwave grips Italy, Spain and France as wildfires rage in Turkey – as it happened  The Guardian
    4. Europe swelters as early summer heat breaks records  DW
    5. Fires break out and most of France put on heatwave alert  Business Recorder

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  • Indian boxers get off to strong start

    Indian boxers get off to strong start

    India’s campaign at the World Boxing Cup Kazakhstan 2025 began on a promising note, with Hitesh Gulia, Sachin Siwach, Minakshi and Muskan picking up opening-day wins in Astana on Monday.

    Competing at the Beeline Arena, Indian boxers Hitesh Gulia and Sachin Siwach started off with unanimous wins in the men’s light middleweight (70kg) and lightweight boxing (60kg) categories, respectively.

    Hitesh Gulia, a gold medallist from the opening leg of the World Boxing Cup in Brazil, outclassed Olympian Kan Chia-Wei of Chinese Taipei 5:0. Sachin, a bronze winner in Brazil, was convincing in his 5:0 win over Canada’s Keoma-Ali Al-Ahmadieh.

    In women’s events, Minakshi began her campaign with a clean 5:0 win over Australia’s Madeleine Bowen in the light flyweight (48kg) division.

    Meanwhile, Muskan edged England’s Kerry Davis in a closely contested 3:2 decision in the middleweight category (75kg).

    Back in April, India had claimed six medals at the previous World Boxing Cup leg in Brazil.

    The Indian women did not compete in Brazil. The tournament in Astana is the second of three scheduled events that help boxers accumulate ranking points throughout the year.

    The Kazakhstan leg will run until July 7, with over 400 boxers from 31 countries, including Olympians, competing across 10 weight categories in both men’s and women’s divisions. India have sent a 20-member team.

    The series will conclude with a final event in India this November, where stage winners and top-ranked boxers will compete for the World Boxing Cup title.

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  • Tens of Thousands of Heart Attacks and Strokes Could Be Avoided Each Year if Cholesterol-Lowering Drugs Were Used According to Guidelines | Johns Hopkins

    Tens of Thousands of Heart Attacks and Strokes Could Be Avoided Each Year if Cholesterol-Lowering Drugs Were Used According to Guidelines | Johns Hopkins

    A new study led by Johns Hopkins researchers has identified a significant gap between the number of U.S. patients for whom cholesterol-lowering drugs such as statins are recommended and the actual number of patients who take them. 

    Coronary artery disease remains a leading cause of death in the U.S. and globally, despite the development of statins and other cholesterol-lowering medications in recent decades. Many adults who should be taking these drugs to lower their low-density-lipoprotein (LDL) levels are not—even though these drugs are considered safe and there is a large body of evidence supporting their effectiveness. In their new study, the researchers sought to quantify this treatment gap.

    In a nationally representative analysis of nearly 5,000 U.S. adults, the researchers found that among those who had never had a major cardiovascular event, just under half—47%—were eligible for cholesterol-lowering drugs under U.S. guidelines but only 23% were taking them. Among those who had a record of a major cardiovascular event, just over two-thirds—68%—were receiving cholesterol-lowering treatment when 100% were eligible for them under 2018 U.S. guidelines.

    The researchers estimate that closing this treatment gap could help prevent nearly 100,000 non-fatal heart attacks in the U.S. each year and up to 65,000 strokes overall in the U.S. each year, and also prevent tens of thousands of heart bypass surgeries and stent-placement procedures annually in the U.S. 

    Bringing treatment in line with recommended U.S. guidelines could save up to $30.6 billion in annual medical costs in the U.S. for these prevented events, the researchers estimate.

    The findings were published online June 30 in the Journal of General Internal Medicine.

    “These results add to a growing body of evidence that there are important shortcomings in the quality of care for common and costly chronic diseases such as high cholesterol, and that addressing those shortcomings would yield major public health benefits,” says study lead author G. Caleb Alexander, MD, a practicing internist and professor in the Johns Hopkins Bloomberg School of Public Health’s Department of Epidemiology.

    For their study, the researchers analyzed data on a nationally representative sample of 4,980 American adults, ages 40–75, from U.S. National Health and Nutrition Examination Surveys taken from 2013 to 2020. The researchers used data for each individual that included LDL-cholesterol levels and cardiovascular risk profiles to determine eligibility for lipid-lowering medications based on 2018 U.S. guidelines, as well as actual use of such medications by U.S. patients. 

    The researchers also analyzed U.S. patient data applying E.U. guidelines. The European guidelines had more aggressive LDL-C goals compared to U.S. guidelines, resulting in wider gaps between observed and recommend care.

    The vast majority of the individuals in the sample—89%—didn’t have a record of a major cardiovascular event such as a stroke, heart attack, or coronary bypass surgery. In this “primary prevention” group, representing about 116 million U.S. adults, only 23% were using lipid-lowering drugs to prevent such events, although 47% were eligible for such drugs under U.S. guidelines.

    Among the 11% of the sample who did have a record of a major cardiovascular event—a “secondary prevention” sample representing about 15 million U.S. adults—only 68% received any LDL-lowering treatment, despite 100% being eligible under both the U.S. and E.U guidelines examined.

    The researchers estimated that if treatment for all eligible individuals were fully aligned with U.S. or E.U. guidelines, including the use of non-statin LDL-lowering drugs in many cases, median levels of LDL cholesterol would drop sharply, reducing the risk of major cardiovascular events in the U.S. by up to 27%. 

    “Several factors account for the gaps that we document,” says Alexander. “They include differences in clinician training, patient preferences, barriers to accessing care, financial incentives that don’t always support best practices, and the difficulty of putting clinical guidelines into practice in busy, real-world settings.”

    Bringing actual treatment closer to what guidelines recommend could be achieved through various measures including better patient education on the benefits of treatment for those who know they have high LDL-cholesterol levels, and better screening for everyone else, the researchers say.

    “High cholesterol is an important chronic health condition that silently claims far too many lives —there are millions of people walking around with this condition that don’t even know they have it, and then when it is recognized it too often goes undertreated. Evidence-based action is critical to close the gap and prevent devastating cardiovascular events,” says study senior author Seth S. Martin, MD, MHS, a practicing cardiologist and professor at the Johns Hopkins University School of Medicine.

    U.S. Public Health Gains from Improved Treatment of Hypercholesterolemia: A Simulation Study of NHANES Adults Treated to Guideline-Directed Therapy” was co-authored by G. Caleb Alexander, Jill Curran, Alejandro Victores, Hemalkumar Mehta, Shanshan Lin, Xuya Xiao, Erin Michos, Jeromie Ballreich, Lori Bash, Jason Exter, Kathryn Foti, and Seth Martin.

    Funding was provided by Merck Sharp & Dohme LLC.

    Disclosures: Caleb Alexander is past chair of FDA’s Peripheral and Central Nervous System Advisory Committee and is a co-founding principal and equity holder in Stage Analytics. Outside of this work, Seth Martin has received personal consulting fees from Amgen, AstraZeneca, BMS, Kaneka, Merck, NewAmsterdam, Novartis, Novo Nordisk, Premier, Sanofi, and 89bio. Outside of this work, Erin Michos has received personal consulting fees from Amgen, Arrowhead, AstraZeneca, Boehringer Ingelheim, Edwards Lifescience, Esperion, Ionis, Lilly, Medtronic, Merck, NewAmsterdam, Novartis, Novo Nordisk, and Pfizer. These arrangements have been reviewed and approved by Johns Hopkins University in accordance with its conflict of interest policies. Alejandro Victores, Lori Bash and Jason Exter are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, New Jersey, USA. Jill Curran is now employed by Boehringer Ingelheim.

    # # #

    Media contacts: Jon Eichberger je@jhu.edu or Kris Henry khenry39@jhu.edu

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  • Mars Orbiter taught to ‘roll over’ for a view beneath the surface

    Mars Orbiter taught to ‘roll over’ for a view beneath the surface

    After nearly two decades in orbit, NASA’s Mars Reconnaissance Orbiter (MRO) is trying something new.

    Engineers have taught the spacecraft how to roll – hard. This isn’t just a simple tilt. These are full-body rolls, sometimes nearly upside down.


    The purpose is to see deeper beneath the surface of Mars and hunt for signs of water and ice.

    Teaching Mars Orbiter to roll

    The new technique comes from scientists at the Planetary Science Institute and NASA’s Jet Propulsion Laboratory.

    Between 2023 and 2024, MRO performed three massive rotations – what the team calls “very large rolls” – to boost the performance of one of its key instruments.

    “Not only can you teach an old spacecraft new tricks, you can open up entirely new regions of the subsurface to explore by doing so,” said Gareth Morgan of the Planetary Science Institute in Tucson, Arizona.

    Advanced planning and careful balance

    Mars Reconnaissance Orbiter was originally built to roll up to 30 degrees to aim its cameras and sensors at specific features on the Martian surface.

    It’s a flexible platform, designed to twist and turn in space so scientists can target impact craters, landing zones, and more.

    “We’re unique in that the entire spacecraft and its software are designed to let us roll all the time,” said Reid Thomas, MRO’s project manager at NASA’s Jet Propulsion Laboratory in Southern California.

    But the bigger rolls – 120 degrees or more – are something else entirely. These require advanced planning and careful balance.

    Mars Orbiter: Why every roll counts

    MRO’s five main science instruments all have different needs. When one is pointed at Mars, others might lose their ideal view.

    That means every maneuver is scheduled weeks in advance. Teams negotiate which instruments will be active and when.

    An algorithm takes over from there, guiding the orbiter to roll and aim while keeping its solar panels locked on the Sun and its antenna aimed at Earth. For very large rolls, even those systems go dark temporarily.

    “The very large rolls require a special analysis to make sure we’ll have enough power in our batteries to safely do the roll,” Thomas said.

    Flipping for stronger radar returns

    The massive rolls are especially helpful for SHARAD, the Shallow Radar instrument on board. It is designed to see about half a mile to 1.2 miles (0.8 – 1.9 kilometers) below the Martian surface.

    SHARAD can also differentiate between ice, rock, and sand – a crucial capability for identifying water that future astronauts might one day use.

    “The SHARAD instrument was designed for the near-subsurface, and there are select regions of Mars that are just out of reach for us,” said Morgan. “There is a lot to be gained by taking a closer look at those regions.”

    Normally, SHARAD’s signals bounce off parts of the orbiter before hitting Mars, which muddies the data. But by flipping the spacecraft 120 degrees, SHARAD gets a clean line of sight. That single move boosts signal strength tenfold or more.

    This improvement is big, but it comes with tradeoffs. During the maneuver, MRO can’t communicate with Earth or recharge its batteries. That limits the team to one or two very large rolls each year – for now.

    Old instruments with new tricks

    SHARAD isn’t the only instrument adjusting to new routines. The Mars Climate Sounder, a radiometer built at JPL, is also leaning into MRO’s roll capability. It tracks temperatures and atmospheric changes on Mars, revealing patterns in dust storms and cloud formations.

    Originally, this instrument used a gimbal to adjust its view. But the gimbal started to fail in 2024. Now, the Climate Sounder depends on the orbiter’s roll maneuvering instead.

    “Rolling used to restrict our science, but we’ve incorporated it into our routine planning, both for surface views and calibration,” said Mars Climate Sounder’s interim principal investigator, Armin Kleinboehl of JPL.

    Mars Orbiter still delivers after 18 years

    NASA’s Mars Reconnaissance Orbiter has been circling the Red Planet since 2006. It’s an aging but incredibly capable machine.

    These new rolling maneuvers show that even after 18 years in space, it’s still finding new ways to contribute.

    By shifting its body in bold new directions, MRO is helping us see what lies beneath the Martian dust – and just maybe, where water waits to be found.

    Image Credit: NASA/JPL-Caltech

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  • Jurors in Sean ‘Diddy’ Combs’s sex-trafficking trial begin deliberations | Sean ‘Diddy‘ Combs

    Jurors in Sean ‘Diddy’ Combs’s sex-trafficking trial begin deliberations | Sean ‘Diddy‘ Combs

    After seven weeks of testimony from more than 30 witnesses, jurors in the high-profile federal sex-trafficking and racketeering conspiracy trial of Sean “Diddy” Combs have begun deliberations.

    The 12-member jury – made up of eight men and four women – began deliberating on Monday, following closing arguments from both sides that concluded on Friday and lengthy instructions from the judge.

    Earlier on Monday, Judge Arun Subramanian told jurors that they were the “sole and exclusive judges of the facts” who are to determine a verdict without bias or prejudice to either of the parties involved.

    He emphasized that prosecutors had the burden of proving Combs is guilty beyond a reasonable doubt, not proof beyond any possible doubt.

    Combs, 55, was arrested in September and faces felony charges: one count of racketeering conspiracy, two counts of sex trafficking and two counts of transportation to engage in prostitution.

    He has pleaded not guilty to all of the charges and denied the accusations against him.

    If convicted, Combs could spend the rest of his life in prison. He has been held without bail at a federal detention center in Brooklyn since his arrest.

    Prosecutors allege that for over two decades, Combs led a criminal enterprise, aided by employees and associates, that engaged in, attempted to engage in and worked to cover up crimes including sex trafficking, kidnapping, forced labor, drug distribution, arson and bribery, enticement to engage in prostitution and obstruction of justice.

    The government has sought to prove that Combs used violence, threats, money, drugs, intimidation and power to abuse and coerce two of his former girlfriends into participating in “freak-offs”, which were described as drug-fueled sex marathons with hired male escorts.

    The defense has insisted throughout the trial that all sexual encounters were consensual and part of a “swingers lifestyle”. They have argued that no criminal conspiracy exists and that Combs is being wrongly prosecuted for his “private” and “personal sex life”.

    Throughout the trial, Combs’s lawyers acknowledged past instances of domestic violence, but denied that Combs committed sex trafficking and that any coercion took place.

    Since the trial began on 12 May, the jury has reviewed dozens of text messages, videos and receipts. The government called 34 witnesses to the stand, including two of Combs’s former girlfriends, multiple former employees and assistants, several male escorts, stylists, hotel workers, law enforcement agents and well-known figures such as the rapper Kid Cudi and singer Dawn Richard, among others.

    Key testimony came from two of Combs’s former girlfriends and alleged victims, singer Casandra “Cassie” Ventura and a woman identified as “Jane”, both of whom described the alleged “freak-offs” in graphic detail and alleged that they were coerced into participating.

    They both testified that Combs directed, watched, masturbated to and sometimes filmed the sexual encounters.

    The women described times where they said Combs was violent with them and they alleged that Combs would threaten to release explicit videos of them or cut off financial support if they didn’t meet his demands.

    During cross-examination, Combs’s lawyers sought to cast Ventura and Jane as willing and consenting participants in the “freak-offs”. Combs’s team presented loving and at times explicit text messages exchanged with Combs – some of which showed the women expressing enthusiasm for the encounters. His lawyers also frequently brought up the role that jealousy and drug use played in their relationships.

    Another woman, a former personal assistant who testified under the pseudonym “Mia”, alleged that Combs physically and sexually assaulted her during her employment.

    Defense attorneys suggested that she fabricated the allegations, and highlighted social media posts and messages from after the alleged assaults in which Mia praised Combs, calling him a “mentor” and an “inspiration”.

    The government rested its case last week. Shortly after, Combs confirmed that he would not be testifying. His legal team also rested its case, but opted not to call any witnesses of its own. Instead, his team submitted evidence to the court and relied on its extensive cross-examinations throughout the trial.

    During closing arguments, the prosecution spent nearly five hours outlining the government’s case against Combs, revisiting testimony from several witnesses, and broke down each allegation against Combs.

    The prosecution described him as “the leader of a criminal enterprise” who refused to “take no for an answer” and alleged that he was someone who wielded “power, violence and fear to get what he wanted”.

    “The defendant was a very powerful man,” she said. “But he became more powerful and more dangerous because of the support of his inner circle and his businesses – the enterprise.”

    The defense offered its closing argument on Friday, and told the jurors that the government’s case against Combs was “false” and “exaggerated”.

    Combs’s lawyer urged the jury to reject the prosecution’s case against Combs and pushed back against the government’s accusations, disputed various pieces of witness testimony, and challenged the prosecution’s portrayal of Ventura and Jane as sex-trafficking victims.

    Combs’s lawyer cast Ventura, the government’s star witness, as a woman with agency, rather than a victim, who willingly participated in the sexual encounters.

    The lawyer also pointed to the $20m settlement she received from Combs in 2023 after filing a civil lawsuit accusing him of abuse, which triggered the federal investigation, as well as the the $10m Ventura is expected to receive from the owner of a hotel in Los Angeles where she was assaulted by Combs in 2016.

    “If you had to pick a winner in this whole thing, it’s hard not to pick Cassie,” Agnifilo said. “This isn’t about a crime, this is about money.”

    Though he did not take the stand, throughout the entire trial, Combs has been engaged and active in his defense, often seen whispering to his lawyers and reacting visibly to testimony.

    Earlier this month, the judge warned that Combs could be removed from the courtroom for looking at and “nodding vigorously” at the jury during a cross-examination.

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