The attack on a church in the suburbs of Damascus left at least 25 people dead
Warning: This article contains distressing details
“Your brother is a hero.”
This is what Emad was told after finding out his brother had been killed in a suicide explosion at a church in the Syrian capital of Damascus.
His brother, Milad, and two others had tried to push the suicide attacker out of the church building. He was killed instantly – alongside 24 other members of the congregation.
Another 60 people were injured in the attack at Greek Orthodox Church of the Prophet Elias, in the eastern Damascus suburb of Dweila on 22 June.
It was the first such attack in Damascus since Islamist-led rebel forces overthrew Bashar al- Assad in December, ending 13 years of devastating civil war.
It was also the first targeting of the Christian community in Syria since a massacre in 1860, when a conflict broke out between Druze and Maronite Christians under Ottoman rule.
The Syrian authorities blamed the attack on the Islamic State (IS) group. However, a lesser- known Sunni extremist group, Saraya Ansar al-Sunnah, has said it was behind the attack – though government officials say they do not operate independently of IS.
Emad, far right, was told his brother (in the photograph) had been a hero trying to stop the suicide attacker
Milad had been attending a Sunday evening service at the church, when a man opened fire on the congregation before detonating his explosive vest.
Emad heard the explosion from his house and for hours was unable to reach his brother.
“I went to the hospital to see him. I couldn’t recognise him. Half of his face was burnt,” Emad told me, speaking from his small two bedroom-home which he shares with several other relatives.
Emad is a tall, thin man in his 40s with an angular face that bears the lines of a hard life. He, like his brother, had been working as a cleaner in a school in the poor neighbourhood, which is home to many lower to middle class and predominantly Christian families.
During Bashar al-Assad’s rule, members of Syria’s many religious and ethnic minority communities believed the state protected them. Now, many fear the new Islamist-led government, established by the rebels who overthrew him last December, will not do the same.
While interim President Ahmed al-Sharaa and his government have pledged to protect all citizens, recent deadly sectarian violence in Alawite coastal areas and then in Druze communities around Damascus have made people doubt its ability to control the situation.
Many of Emad’s family members echoed this sentiment, saying: “We are not safe here anymore.”
Angie, 23, no longer wants to stay in Syria after being injured in the attack
Angie Awabde, 23, was just two months away from graduating university when she got caught up in the church attack.
She heard the gunshots before the blast.
“It all happened in seconds,” she told me, speaking from her hospital bed as she recovers from shrapnel wounds to her face, hand and leg, as well as a broken leg.
Angie is frightened and feels there is no future for Christians in Syria.
“I just want to leave this country. I lived through the crisis, the war, the mortars. I never expected that something would happen to me inside a church,” she said.
“I don’t have a solution. They need to find a solution, this is not my job, if they can’t protect us, we want to leave.”
Before the 13-year civil war, Christians made up about 10% of the 22 million population in Syria – but their numbers have shrunk significantly since then with hundreds of thousands fleeing abroad.
Churches were among the buildings bombed by the Syrian government and allied Russian forces during the war – but not while worshippers were inside.
Thousands of Christians were also forced from their homes due to the threat from hardline Islamist and jihadist groups, such as IS.
Izettin Kasim/Anadolu via Getty Images
A mass funeral ceremony was held last week for the victims of the 22 June attack
Outside the hospital where Angie is being treated, coffins of some of the victims of the church attack were lined up, ready for burial.
People from all walks of life, and representing different parts of Syrian society, attended the service at a nearby church, which took place under a heavy security presence.
In a sermon at the service, the Patriarch of the Greek Orthodox Church in Syria, John Yazigi, insisted “the government bears responsibility in full”.
He said a phone call from President Ahmed al-Sharaa expressing his condolences was “not enough for us”, drawing applause from the congregation.
“We are grateful for the phone call. But the crime that took place is a little bigger than that.”
Sharaa last week promised that those involved in the “heinous” attack would face justice.
A day after the bombing, two of the suspects were killed and six others arrested in a security operation on an IS cell in Damascus.
But this has done little to allay fears here about the security situation, especially for religious minorities.
Syria has also seen a crack down on social freedoms, including decrees on how women should dress at beaches, attacks on men wearing shorts in public and bars and restaurants closing for serving alcohol.
Many here fear that these are not just random cases but signs of a wider plan to change Syrian society.
Archimandrite Meletius Shattahi, director-general of the charitable arm of the Greek Orthodox Patriarchate of Antioch, feels the government is not doing enough.
He refers to videos circulating online showing armed religious preachers advocating for Islam over loud speakers in Christian neighbourhoods, saying these are not “individual incidents”.
“These are taking place in public in front of everybody, and we know very well that our government is not taking any action against [those] who are breaching the laws and the rules.”
This alleged inaction, he says, is what led to the attack at the Church of the Prophet Elias.
Christian Horner was left to rue a “very frustrating” sequence of events in Sunday’s Austrian Grand Prix after Red Bull left their home race without scoring any points.
Max Verstappen completed only two corners at the Red Bull Ring before being taken out of the action by Mercedes rival Kimi Antonelli, who misjudged his approach to Turn 3 and subsequently earned a three-place grid penalty for Silverstone.
Yuki Tsunoda, meanwhile, was the final finisher in 16th position, having struggled to make an impression after his Q1 exit and been given a 10-second penalty for tipping Franco Colapinto’s Alpine into a spin exiting Turn 4.
The result means Red Bull fall even further behind their rivals in the Teams’ Championship, holding 162 points to McLaren’s 417, while Verstappen is 61 adrift of Oscar Piastri in the Drivers’ standings.
“A frustrating day,” Red Bull team boss Horner summed up on F1 TV’s post-race show. “Starting with Max, he had a great start and was well-positioned for Turn 1. At Turn 3 unfortunately Kimi just lost control and wiped him out. Very frustrating… Obviously Kimi’s apologised. It is what it is.
“I think when you look at the pace, we wouldn’t have fought the McLarens today, but we’d have fought the Ferraris hard, for sure. George [Russell] had no pace. It was frustrating.
“With Yuki, it’s difficult to make progress starting where he did on the grid, then picking up a penalty as well with Colapinto. A horrible race for him today as well. Frustrating, but we’ll move on quickly to Silverstone.”
With that in mind, Horner was asked how Red Bull can “remedy” the struggles several drivers have now faced in the seat alongside Verstappen – and ensure that both cars are in a position to score points moving forward.
“We need to understand with Yuki what’s gone wrong [this weekend],” he continued. “FP1 and FP2, certainly FP2 and FP3, he was looking okay. Qualifying it seemed to fall apart for him.
“When you’re out of position, you’re down the pack like that, when it’s so tight… he’s struggling, I think he’s struggling for confidence. But we’ll work with him, we’ll try and help him through it.
“The car is… it’s a car that’s evolved over the years around the development path that we’ve taken. It isn’t an easy car to drive, but it’s not that difficult either. We’ll work with him and hopefully it’ll make a step up in Silverstone.”
Given the significant gaps that have developed in both championships, Horner knows Verstappen and Red Bull now face a tall order to add to their recent title successes in 2025.
“Well, look, the championship we’re not even thinking about,” he conceded. “We’re just focused on each race now. They’re [McLaren] a long way out of touch. We’ll just take things race by race.
Verstappen has won the last four Drivers’ titles on the bounce, while Red Bull were crowned Teams’ champions in 2022 and 2023 before being overhauled by McLaren last season.
Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function. Because of this, water molecules represent a powerful but largely underappreciated foothold in drug binding studies. Yet structural data about these water networks, usually collected at freezing temperatures, often carry temperature-based structural artifacts. St. Jude Children’s Research Hospital scientists have unveiled a new computational tool called ColdBrew to address this problem. The tool leverages data on extensive protein water networks to predict the likelihood of water molecule positions within experimental protein structures, potentially aiding drug discovery efforts. ColdBrewwas published today in Nature Methods.
Proteins have evolved to fold precisely according to the repulsion and attraction of their amino acid building blocks to water. Water is also key to their activity since it helps guide other molecules, including drug molecules, to bind effectively. Drug discovery efforts based on protein structures use techniques such as X-ray crystallography and cryo-electron microscopy, but these techniques use freezing, or “cryogenic” temperatures, which can distort how water molecules appear. Marcus Fischer, PhD, St. Jude Department of Chemical Biology & Therapeutics, recognized this as a missed opportunity.
Water molecules in protein structures have so many degrees of freedom that drug discoverers typically throw them out. They’re kind of inconvenient.”
Marcus Fischer, PhD, St. Jude Department of Chemical Biology & Therapeutics, corresponding author on the study
With ColdBrew, seeing is believing
To put this lost information to work, Fischer and first author Justin Seffernick, PhD, St. Jude Department of Chemical Biology & Therapeutics, developed ColdBrew. “Our goal was to make a tool that’s easy to use and understand,” said Seffernick. “For each water molecule, our method can tell us how likely water is to be present at higher temperatures. We also found that this same metric can give us clues about how ligands bind to proteins.”
This is particularly important to drug discovery. “When ligands bind to proteins, they kick out water from binding sites, so we need to pay attention to them in ligand design,” said Fischer. “Encouragingly, we’ve seen in our data that our predictions were best within these binding sites and around ligands.”
Considering that cryogenic structure-solving techniques can artificially increase the number of water molecules present in a structure, a tool such as ColdBrew can assure researchers that seeing is believing. To this end, Fischer and Seffernick have amassed and made publicly available a comprehensive library based on ColdBrew calculations.
“To enable the wide use of ColdBrew, we performed calculations on every structure that fit our criteria in the entire Protein Data Bank. We have over 100,000 predictions, which is over 46 million water molecules,” Fischer said. “Remarkably, our results show that drug designers unknowingly avoid tightly bound waters, so actually knowing which ones to avoid could guide the process.”
Authors and funding
The study was supported by grants from the National Institutes of Health (R35GM142772) and the American Lebanese Syrian Associated Charities (ALSAC), the fundraising and awareness organization of St. Jude.
Source:
St. Jude Children’s Research Hospital
Journal reference:
Seffernick, J. T., & Fischer, M. (2025). An experimental proxy of water displaceability for ligand discovery. Nature Methods. doi.org/10.1038/s41592-025-02724-0.
Amazon’s Prime Day sale is just over a week away, and iPad prices on the retailer’s website are starting to reflect that.
SEE ALSO:
These Prime Day deals landed early — save on Apple, Ninja, and Samsung gadgets
Though Apple deals can range from decent to great at Amazon year round, Prime Day tends to bring a higher concentration for deals. Though the sale doesn’t kick off until July 8, the site already marked down every single model of the iPad, from the mini to the Pro.
Below, you’ll find our top picks for each model, but if nothing catches your eye so far, don’t worry — we’ll be updating this list all the way through Prime Day.
Best iPad deals
Why we like it
Check out Mashable’s full review of the iPad mini.
Mashable Deals
The iPad mini may not be the best tablet for creatives or professionals who need the highest-powered tablet out there. However, for folks who mostly enjoy using their tablet for streaming or reading, this ultra-portable tablet checks the boxes. The 128GB of storage will likely be more than enough for less intensive tasks, and at 8.3-inches, it feels comfortable to hold for longer periods of time. (For anyone not particularly into the tech color e-readers are offering at the moment, this iPad gives a great alternative with some more versatility).
APP36-300625 KARACHI: June 30 – Police stop the protesters belonging to Sindh Employees Association outside the Press Club. APP/SDQ/TZD
APP37-300625 KARACHI: June 30 – Police use tear gas to disperse protesters belonging to Sindh Employees Association outside the Press Club. APP/SDQ/TZD
LAHORE: While conflict raged between the powerful militaries of India and Pakistan, a battle was also fought on the cultural front lines despite years of shared love for films and music.
The deadly fighting in early May — the worst in decades — affected artists previously untouched by animosity between their leaders.
Ali Gul Pir, a Pakistani rapper and comedian with a huge Indian following, released a song years ago mocking Indian Prime Minister Narendra Modi.
While he was spared consequences then, in May, his YouTube channel and Instagram profile were blocked in India.
“Indians now recognize that the digital space serves as a bridge between Pakistanis and Indians, and they seem intent on severing that connection,” Pir told AFP.
In this photograph taken on June 17, 2025, a man looks at a film poster, Love Guru, featuring Pakistani actress Mahira Khan, outside a cineplex in Lahore. (AFP)
The collapse in bilateral relations was caused by a deadly April attack on tourists in India-administered Kashmir, which New Delhi blamed on Islamabad.
Pakistan denied the allegation and, after tit-for-tat diplomatic retaliation, their militaries fought for four days before a ceasefire was reached.
The conflict hit the music industry for the first time, with Pakistani singer Annural Khalid also remembering how her Indian following dropped off.
“Delhi was my top listening city before the ban,” said Khalid, who has 3.1 million monthly listeners on Spotify.
“I suffered a great loss in the audience” from India, she told AFP.
“Listeners were deprived of content because music was turned into something it is not,” Khalid added.
In this photograph taken on May 29, 2025, Pakistan’s pop singer Annural Khalid sings inside her studio in Lahore. While conflict raged between the powerful militaries of India and Pakistan, a battle was also fought on the cultural front lines despite years of shared love for films and music. (AFP)
The conflict also scrubbed out some prior exchanges, such as the soundtrack of the 2017 film “Raees” on Spotify in India.
It now shows only Indian actor Shah Rukh Khan, without his Pakistani co-star Mahira Khan.
With Pakistan producing just a handful of movies each year under strict censorship rules, Bollywood has always proven popular among viewers.
“I grew up watching Bollywood. We have the same traumas, we have the same history, we have the same stories,” said Pakistani film critic Sajeer Shaikh.
In this photograph taken on May 23, 2025, Sajeer Shaikh, a Pakistani film critic and content creator, speaks with AFP during an interview in Karachi. (AFP)
Pakistani actors and directors have for decades seen making it to Bollywood as the ultimate recognition.
Indian Bollywood film actresses Sonam Kapoor (C) and Kirron Kher (L), and Pakistani actor Fawad Afzal Khan (2L) watch the daily retreat ceremony performed by Pakistani Rangers and Indian Border Security Force (BSF) personnel at India-Pakistan Border Wagah Post on September 17, 2014. (AFP/File)
But this month, Indian star Diljit Dosanjh announced his latest movie, “Sardaar Ji 3,” which features four Pakistani actors, would be released “overseas only,” after New Delhi banned Pakistani content and artists from productions.
“Abir Gulaal,” a love story starring Pakistan’s Fawad Khan and Indian actor Vaani Kapoor, was scheduled to hit Indian cinemas on May 9 but the release was postponed.
Even some in the industry who had previously backed the cross-border artistic trade changed their tune last month.
“Everything should be banned… cricket, films, everything,” said Indian actor Suniel Shetty, who has a big fan following in Pakistan.
In this photograph taken on June 17, 2025, a young boy walks past a film poster, Love Guru, featuring Pakistani actress Mahira Khan, inside a cineplex in Lahore. (AFP)
He starred in the 2004 movie “Main Hoon Na,” which subtly promotes peace between India and Pakistan.
“It’s something really unfortunate about politics, creating that rift and putting boundaries around art,” said Dua Zahra, assistant manager at Warner Bros South Asia’s music label in Pakistan.
As part of its measures in the wake of the Kashmir attack, New Delhi’s ban on some Pakistani YouTube channels included private broadcaster HUM TV.
The channel, which says around 40 percent of its viewers are from India, simply told its fans to use a VPN to continue watching.
Since Modi took office more than a decade ago, many Indian critics and filmmakers have warned that Bollywood is now increasingly promoting his government’s Hindu nationalist ideology.
While the conflict has created divisions on the cultural scene, there are signs that the trade will endure.
Over a month after the ceasefire, three Indian films were in the top 10 on Netflix Pakistan, while the top 20 trending songs in India included two Pakistani tracks.
Pir, the rapper and comedian, vowed to “bridge gaps.”
“Let’s not make war, let’s just make art,” he said.