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  • Poem of the week: Search Engine: Notes from the North Korean-Chinese-Russian Border by Suji Kwock Kim | Poetry

    Poem of the week: Search Engine: Notes from the North Korean-Chinese-Russian Border by Suji Kwock Kim | Poetry

    Search Engine: Notes from the North Korean-Chinese-Russian Border

    By which a strip of land became a hole in time – Durs Grünbein

    Grandfather I cannot find,
    flesh of my flesh, bone of my bone,
    what country do you belong to:

    where is your body buried,
    where did your soul go
    when the road led nowhere?

    Grandfather I’ll never know,
    the moment father last saw you
    opens a wormhole

    that has no end: the hours
    became years, the years
    forever: and on the other side

    lies a memory of a memory
    or a dream of a dream of a dream
    of another life, where what happened

    never happened, what cannot come true
    comes true: and neither erases
    the other, or the other others,

    world after world, to infinity –
    If only I could cross the border
    and find you there,

    find you anywhere,
    as if you could tell me who he is, or was,
    or might have become:

    no bloodshot eyes, or broken
    bottles, or praying with cracked lips
    because the past is past and was is not is

    Grandfather, stranger,
    give me back my father –
    or not back, not back, give me the father

    I might have had:
    there, in the country that no longer exists,
    on the other side of the war –

    This week marks a return-visit to the work of the award-winning Korean-American-British poet and playwright Suji Kwock Kim. It’s from her pamphlet Notes from the North, published by Smith/Doorstop in 2022, and was a 2019 winner of its annual International Book and Pamphlet competition. Focused on the violent disruptions experienced by the poet’s family members during the Korean war and subsequent North Korean dictatorship, the collection was described by Amy Wack, one of the competition judges, as “a scorched family album, rescued from the ruin”.

    Search Engine is an invocation to the poet’s grandfather, circling round a series of three apostrophes that suggest the intensifying fact of his absence: “Grandfather I cannot find”, “Grandfather I’ll never know” and “Grandfather, stranger”. That the voice in its fruitless search reverberates over much of human history, 20th century history in particular, is signalled by the epigraph. In the East German poet Durs Grünbein’s Portrait of the Artist as a Young Border Dog, the dog remembers the now-invisible border and the “strip of land” he once guarded: “Watchtowers are forgetful, / Like eyes which have been torn from their sockets. / Gone already: the separating place’s / Two or three names. // The trick’s now unbetrayed / which made a strip of land a hole in time. / I’m glad my brow does not reveal a thing.”

    Kim’s triplet stanza gives a sense of the circularity of the search-within-a-search enforced by the “hole in time”. For her, the hole is a wormhole. In her quest for the specificity she needs to flesh out the truth of her past, the searcher asks her grandfather: “what country do you belong to: // where is your body buried, / where did your soul go / when the road led nowhere?” Why these questions are urgent is explained in the preceding poem, Searchlight. The grandfather leaves his 10-year-old son (the poet’s future father) in a forest in North Korea’s far north, “whispering Wait in the woods until I come back.” But the boy’s father doesn’t return, ever. The poem evolves into a series of agonised questions as to why the abandoned son hasn’t tried to find him. The searchlight’s brightest illumination is saved for the questioner’s final sharp pang of insight: “Is it better not to know what happened, as if the not-knowing could keep him alive?”

    While the “searchlight” has become a “search engine” in the current poem, the wormhole of infinite connections flows on: it “has no end”, as time, for the child, waiting in the woods for his father to return, would have seemed to have no end. There is still a border between now and the past, and “on the other side // lies a memory of a memory / or a dream of a dream of a dream / of another life …” The puzzle of alternative possibilities is interrupted in the ninth stanza by the device of making the challenged reality so harshly present it shoulders all alternative dreaming aside: “no bloodshot eyes, or broken / bottles, or praying with cracked lips / because the past is past and was is not is But again, there’s a feeling of circularity in the shifts of consciousness suggested, between drunkenness and thirst, or sleeplessness and prayer.

    Scrupulously precise, despite her passion, the speaker utters her last plea (“Grandfather, stranger, / give me back my father –”) and instantly checks herself, “or not back, not back, give me the father // I might have had …” In the search engine of the poem, complexity of thought always coexists with openly expressed emotion. The title metaphor implies that the desire for answers could, should, be matched by the availability and interconnectivity of facts; if it’s not, the drive to go on seeking answers in the absence of connection can be relentless. Physics can’t help the recovery of the lost “flesh of my flesh, bone of my bone …” Time can’t be reversed, and the search is abandoned unfinished, “there, in the country that no longer exists, / on the other side of the war –”

    Kim writes, “There are an estimated 10 million separated families (이산가족) divided between North and South Korea, including my own.” For additional context, her short essay, no end / to the end, is essential reading.

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  • Trump’s promise of a US manufacturing renaissance leaves experts scratching their heads | Trump tariffs

    Trump’s promise of a US manufacturing renaissance leaves experts scratching their heads | Trump tariffs

    Donald Trump’s hugely disruptive trade war is setting the stage for a manufacturing renaissance in the US, administration officials say. Outside the White House, many economists are skeptical.

    Global trade experts point to many reasons they believe the president’s tariffs will fail to bring about a major resurgence of manufacturing, among them: Trump’s erratic, constantly changing policies, his unfocused, across-the-board tariffs, and his replacing Joe Biden’s carrot-and-stick approach to brandish sticks at the world.

    “I think [Trump’s tariffs] will reduce the competitiveness of US manufacturing, and will reduce manufacturing employment,” said Michael Strain, an economist at the conservative American Enterprise Institute (AEI). “They’re raising the costs of production to US manufacturing companies, and that makes manufacturers less competitive. There will be some winners and some losers, but the losers will outnumber the winners.”

    ‘Trump keeps changing his mind’

    The president and his aides insist that higher tariffs on more than 100 countries – making goods imported from overseas more expensive – will spur domestic manufacturing. “The ‘Made in USA’ label is set to resume its global dominance under President Trump,” the White House spokesperson Kush Desai claimed recently.

    But few economists see that happening. Ann E Harrison, an economics professor and former dean of the Haas School of Business at the University of California, Berkeley, said the erratic, on-again-off-again rollout of Trump’s tariffs has already gone far to doom the president’s hopes of inspiring a huge wave of manufacturing investment.

    “For the policy to be successful, it has to be consistent over a long period,” she told the Guardian. “People need to believe it’s going to last. Some factories take five years to plan and build. You’re talking a long-term play. But Trump keeps changing his mind. Even over the last six months, we’ve had very little consistency.

    “The other problem is that he’s old, and no one is sure he’s going to be around that long. These policies need to be consistent, and that’s not happening.”

    Economists point to another question mark that is causing corporate executives to think twice about building factories in the US. In May, the US court of international trade ruled that Trump’s blanket tariffs are illegal – a decision that is under appeal.

    Strain, at the AEI, said: “When you add into the equation the erratic nature of President Trump’s tariff regime, when you add the question of its questionable illegality, when you add that none of this is going through Congress, when you add that even when the US secures a ‘deal’ with another country, it’s not really a deal, there are major outstanding questions.”

    France doesn’t think its alcohol exports will be hit by tariffs as part of the European Union’s agreement to pay 15% tariffs, noted Strain. “That’s a big question mark that would never go unresolved in any regular, traditional trade deal,” he said. “That’s all part of the massive uncertainty we’re seeing.”

    The Biden administration used deliberate industrial policies to boost several strategic industries, most notably semiconductors and electric vehicles, including a 100% tariff on EVs from China and 25% on lithium-ion EV batteries, as well as subsidies to buy EVs and build EV-related factories. The policies resulted in a surge in new factories to build semiconductors, electric vehicles and EV components.

    Biden “said we care about semiconductors and national security, and what he’d try to do is get actual investors to invest in it”, said Dani Rodrik, an economist specializing in trade and industrial policy at Harvard’s Kennedy School of Government, who predicted Trump’s blanket tariffs will prove less successful in inspiring investment. “If you really want to increase manufacturing and employment in the US, you’d go about it in a very different way, through industrial policies that first identify specific segments you care about.”

    When China, Japan and South Korea adopted policies to build their electronics and auto industries, they insisted that the corporations that benefited from those policies compete with foreign companies to help make them globally competitive. “For industrial policy to succeed, it has to work to promote more competition,” said Harrison, at the Haas School of Business. “The problem with tariffs is they do just the opposite. They restrict competition.”

    Susan Helper, an economist at Case Western Reserve University who worked on industrial policy in the Biden and Obama administrations, said Trump’s tariff rates on some countries and markets – like 15% on the EU, Japan and South Korea – are too low to spur much investment, questioning why a company would build a major factory to circumvent such a duty.

    “A [semiconductor fabrication] plant, that’s a billion dollars. You need to get a payback and that takes several years,” Helper said. “If the tariffs are 145% [as Trump once imposed on China], that’s attractive for building a plant. But if they fall back to 15%, then it’s really hard to get a return on your investment.”

    The administration boasts that several of its trade deals have specific commitments to spur huge manufacturing investment. It says its deal with the EU includes a $600bn investment pledge; with Japan, a $550bn investment pledge; and with South Korea, $350bn. Jamieson Greer, US trade representative, wrote in the New York Times: “These investments – 10 times larger than the inflation-adjusted value of the Marshall Plan that rebuilt Europe after World War II – will accelerate US reindustrialization.”

    But these supposed pledges have attracted skepticism. After all, this president claimed during his first term that “the eighth wonder of the world” was being built in Wisconsin after FoxConn pledged to invest $10bn and create 13,000 jobs at an electronics plant. But that promise fell embarrassingly short.

    Many economists question whether the EU, Japan or South Korea can force corporations to make a specific investment in the US. Indeed, a European Commission spokesperson said the bloc had expressed “aggregate intentions” that are “in no way” binding. “These large numbers really sound like window dressing, some round numbers they’re throwing around,” said Harvard’s Rodrik.

    “Some include investments you were already going to make, and some are aspirational,” said Todd Tucker, a trade and industrial policy expert at the Roosevelt Institute. “Once we’ve had time to evaluate whether the investment happens or not, Trump will be on to the next press cycle.”

    In recent years, manufacturing employment has been trending downward – not just in advanced industrial countries, but also in China, as new technologies enable factories to churn out goods more efficiently, with fewer workers. That trend raises questions whether Trump’s trade policies can increase factory jobs in the US.

    ‘An island of backwardness’

    The US is past its manufacturing peak, Berkeley’s Harrison noted. “That was actually during World War Two, and it has been declining ever since,” she said. “I don’t see manufacturing’s share of the economy or manufacturing employment reversing.”

    She added: “If the question is, are you going to bring about a major resurgence in manufacturing employment, it’s not just unlikely, the answer is no. More and more manufacturing is robot-driven and not done by people.”

    Auto industry officials in the US complain that Trump’s 50% tariffs on steel and aluminum have increased their costs and injured their competitiveness. “In manufacturing, for every one job in steel production, there are 80 jobs that use steel,” the AEI’s Strain said. “So putting tariffs on imported steel might help that one guy, but you’re hurting the other 80 people.”

    A study by Federal Reserve economists found that the tariffs Trump imposed in his first term were actually associated with a reduction in factory jobs nationwide, because increased input costs and retaliatory tariffs outweighed import protection from tariffs.

    Helper, at Case Western Reserve University, warned that the US auto industry would be hurt badly by Trump’s mishmash of tariffs coupled with his slashing subsidies for EVs. “Trump’s policies are setting the auto industry up to be an island of backwardness,” she said. “The rest of the world is going to be making EVs, but we’re going to be focused on making really high profits on pickup trucks that will be bad for the climate and won’t sell in the rest of the world.

    “We’ll have a great, competitive position in large, gas-guzzling pickups, but we’ll fall further behind in EVs. That’s a very risky and dangerous path.”

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  • Bundesliga referee and Rhine-Ruhr 2025 FISU World University Games Chief Sports Officer

    Bundesliga referee and Rhine-Ruhr 2025 FISU World University Games Chief Sports Officer

    Meet the inspiring Sina Diekmann, whose ability to make a quick decision and to communicate it effectively has taken her to leading positions on and off the football pitch.

    Sina Diekmann, 36 years-old, was one of the first five employees in the Rhine-Ruhr 2025 FISU World University Games’ organising committee. “I have been here for the whole journey, in charge of three functional areas”, she explains. “Working for the Games during the week, and on the weekends on duty as a football referee.”

    She has been in the middle of the pitch of the women’s top division in Germany for 10 years now and was also a FIFA assistant (line judge) up until this year. “I did both on a high level, but then had to choose, and I definitely prefer the whistle to the flag!” she admits with a smile.

    Before Games Time, Sina Diekmann had gotten into the habit of changing from the navy RR2025 top into her black or coloured uniform and drop the mouse, pen or microphone for a whistle and possibly yellow or red card come every Friday evening.

    She tells us about her story and hopes to inspire many young men and women to take up refereeing careers, as the programme YouRef encourages them to do.

    -Sina, what made you suddenly pick up refereeing?
    -My grandfather Jochen was a referee and I was his only grandchild who played football. Every time I saw him, he bugged and bugged again for me to try to be a referee. So in the end I did the beginners course only to shut him up… and ended up liking a lot!

    -So you were both a footballer and a referee?

    Yes, I played football up until the age of 19, and started refereeing at 15-years-old. But of course I had to chose, since all games are scheduled during the weekends. I never regretted my choice!

    -According to you, what makes a good referee?

    -First of all I would say being stress resistant and the ability to focus and remain in your bubble. Then be patient with yourself and learn the other skills. You end up adding new ones to your “toolkit” every match. And of course I believe it is important to have practiced the sport you are working in, to have an insider understanding of it.

    Speaking of the Games during the week…
    © Rhine-Ruhr 2025/Andrea Bowinkelmann
    And posing for the official Women’s Bundesliga picture at the weekend. Two sides of the same person. ©Yuliia Perekopaiko/DFB

    -In both your roles, communication is also key…
    -Of course! The communication with the referee assistants and fourth officials has to be well practiced. You always have to be the leader in that small team. Body language is also key. I try to remain clear, respectful and transparent. But of course this also depends on how the players approach me… This of course is also the case in everyday life.

    Different microphones, different attitudes, but Sina
    Diekmann always manages to get her message across. © Tobias Mühlsteff and Rhine-Ruhr 2025/Andrea Bowinkelmann

    -From the outside, refereeing seems pretty tough…
    -I would still recommend it to everyone! You learn so many tools that you can use for your private and professional lives. Like being neutral and diplomatic, like making fast and clear decisions, which is often pretty hard. And then moving on, because what is done is done. It really boosts your self-confidence and you learn so much about yourself. When you manage to deal with the amount of stress that comes with directing even a low level game, you are so proud of yourself.

    -Do referees who share the same passion spend time together outside the pitch?
    -Of course! Huge socialising is part of the fun and I have been making great friendships for over 15 years. We are always part of the game and of a bigger team. I have seen so many cool stadiums and travelled to many great places. These are experiences that money can’t buy!

    Sina Diekmann adressing the Heads of Delegations of the participants with Organising Committee CEO Niklas Börger during a meeting in spring.| © Rhine-Ruhr 2025/Andrea Bowinkelmann

    -Are you involved in teaching young referees?
    -I sometimes take part in regional courses, yes, and share my experiences. It is so cool to see you are an inspiration.

    -What else can help promote refereeing?
    -There have been documentaries on referees, on how they see the game from the inside which are super interesting. And in the Bundesliga, you can collect cards with referees on them.

    -How has this carrer changed you?
    -As I said, it has changed me a lot for the better, but I must admit that never again will I watch a football game the same way: my eyes always go on the referee first. It doesn’t happen with other team sports…

    -And we imagine you have made your grandfather proud…

    -Oh yes, he collected all my autograph cards and every single article that was ever written about me.

    If you are interested in a career in refereeing or to find out more, click here and follow YouRef on LinkedIn.

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  • As her kids turn 18, Angelina Jolie may be looking to sell her historic $24.5 million L.A. estate

    As her kids turn 18, Angelina Jolie may be looking to sell her historic $24.5 million L.A. estate

    By Charlie Lankston

    Jolie said that she was bound to remain in L.A. under a custody agreement

    Angelina Jolie poses at the Cannes Film Festival on May 16, 2025 in Cannes, France.

    Actress Angelina Jolie is said to be getting ready to part ways with the historic Los Angeles estate that she has called home for the last eight years-as she prepares for a move away from the U.S.

    According to multiple reports, the Oscar-winning starlet is planning to “put the house up for sale” in the coming months with a view of relocating abroad when her youngest children, twins Knox and Vivienne, turn 18 in July next year.

    Jolie, 50, has previously revealed her desire to live outside of the U.S., telling The Hollywood Reporter that she was only residing in California because it was one of the conditions of her divorce settlement from her ex-husband, Brad Pitt.

    Speaking to the outlet about the terms of the agreement with Pitt, 61, in the 2024 interview, Jolie revealed that she was bound to remain in L.A. until all of their children reach the age of 18, admitting at the time that she hoped to spend “a lot of time in Cambodia” when she leaves.

    Brad Pitt and Angelina Jolie in 2015 in New York City.

    Now, as that date approaches, sources claim that Jolie is beginning to make preparations for her exit from U.S. soil, with an insider telling People: “[Angelina] plans to relocate as soon as Knox and Viv turn 18 next year. She’s eyeing several locations abroad. She’ll be very happy when she’s able to leave Los Angeles.”

    “[She] never wanted to live in L.A. full time. She didn’t have a choice because of the custody arrangement with Brad.”

    Part of those preparations, the insider said, will be making some minor improvements to her historic home, which is known as the Cecil B. DeMille estate in honor of the famed director, who lived there for 40 years until his death in 1959.

    Jolie took on that slice of Hollywood history in 2017, when she purchased the property for $24.5 million-later explaining that she had chosen the home because of its proximity to her former spouse, from whom she split in 2016.

    “I wanted it to be close to their dad, who is only five minutes away,” she told British Vogue in 2021.

    After her separation from Pitt, with whom she shares six children: Maddox, 24, Pax, 21, Zahara, 20, Shiloh, 19, Knox and Vivienne, the pair became embroiled in a bitter divorce battle that saw them sparring over custody arrangements, shared properties, and even involved allegations of abuse.

    From left, Shiloh Jolie-Pitt, Zahara Jolie-Pitt, Angelina Jolie, Vivienne Jolie-Pitt, Maddox Jolie-Pitt and Knox Jolie-Pitt attend an event in London in 2021.

    That legal battle raged on for eight years before finally being settled in December 2024.

    And while both parties have only shared a few scant details about their split, Jolie did hint at some of the legal details agreed upon by herself and Pitt when she spoke out about the nature of their custody agreement and the restraints that it has put on her life.

    “I grew up in this town. I am here because I have to be here from a divorce, but as soon as they’re 18, I’ll be able to leave,” she told The Hollywood Reporter about her reasons for remaining in Los Angeles.

    “When you have a big family, you want them to have privacy, peace, safety. I have a house now to raise my children, but sometimes this place can be … that humanity that I found across the world is not what I grew up with here. [After Los Angeles,] I’ll spend a lot of time in Cambodia. I’ll spend time visiting my family members wherever they may be in the world.”

    More from Realtor.com: I’m 55 With a $125K Salary and I Bought a Home with Secret Rooms in Utah for $330K

    For much of the time since her split from Pitt, Jolie has resided primarily in the historic 11,000-square-foot abode in Los Feliz, which was built back in 1913, and boasts six bedrooms and 10 bathrooms.

    In addition to its many bedrooms and bathrooms, the Beaux Arts-style mansion, which was built in 1913, also offers an array of living spaces, including a “beautiful pool house” and a “studio house” that has its own entrance.

    More from Realtor.com: Buffalo Home Hits the Market for $1 To Let Buyers Decide the ‘True Value’

    And while the home maintains its historic appearance, it underwent an extensive six-year renovation before Jolie purchased it-with the picture-perfect grounds and the swimming pool also given a meticulous overhaul.

    “A newer classic old Hollywood style pool with arched fountains, surrounded by rolling lawns, specimen trees, rose gardens, and dramatic views from the Observatory to Ocean sunsets,” the original listing description said.

    Should Jolie follow through with her plans to move abroad, she will join a long line of celebrities who have quit the U.S. in recent months-with many pointing to President Donald Trump’s reelection as the reason for their relocation.

    More from Realtor.com: Here’s How First-Time Homebuyers Can Personalize Their Homes Without Breaking the Bank

    Among those who have fled further afield are actress Rosie O’Donnell, who revealed in January that she had moved to Ireland along with her youngest child, Dakota “Clay” O’Donnell, 12, who is nonbinary.

    At the time, O’Donnell said that she no longer felt “safe” living in the U.S. under Trump’s presidency-a declaration that saw him threatening to revoke her citizenship for good.

    More from Realtor.com: Record Number of Luxury Homes Hit the Market in Las Vegas-and Sellers Are Slashing Prices

    Meanwhile, Ellen DeGeneres recently confirmed for the first time that her decision to move to the U.K. with her wife, Portia de Rossi, was prompted by Trump’s victory in the 2024 election, telling British broadcaster Richard Bacon that they had originally only intended to reside in the country for a few months out of the year.

    “We got here the day before the election and woke up to lots of texts from our friends with crying emojis, and I was like, ‘He got in,’” she explained during a July 20 appearance at the Everyman theater in Cheltenham, England. “And we’re like, ‘We’re staying here.’”

    This story originally ran on Realtor.com.

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    08-18-25 0501ET

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  • Schools closed again amid heavy rainfall, flash floods – ARY News

    1. Schools closed again amid heavy rainfall, flash floods  ARY News
    2. Schools in Bagh closed amid high flood alert  nation.com.pk
    3. Rains lash wide parts of Kashmir valley  Press Trust of India
    4. Heavy Downpour in Poonch Raises Fear of Flash Floods, Landslides  Asian Mail
    5. Weather advisory issued in Pir Panjal  Greater Kashmir

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  • Louis Partridge, James Norton in New Netflix Show

    Louis Partridge, James Norton in New Netflix Show

    Netflix has unveiled the key art and first-look images of its cast for House of Guinness.

    Louis Partridge, Anthony Boyle, Emily Fairn, Fionn O’Shea and James Norton star in the new show from Peaky Blinders mastermind Steven Knight — airing Sept. 25 on the streamer — about one of Europe’s most enduring dynasties.

    Set in 19th-century Dublin and New York, the story begins immediately after the death of Sir Benjamin Guinness, the man responsible for the extraordinary success of the Guinness brewery, and the far-reaching impact of his will on the fate of his four adult children, Arthur (Boyle), Edward (Partridge), Anne (Fairn) and Ben (O’Shea), as well as on a group of Dublin characters who work and interact with the phenomenon that is Guinness.

    The star-studded cast also includes Dervla Kirwan (True Detective: Night Country), Jack Gleeson (Game of Thrones), Niamh McCormack (Everything Now), Danielle Galligan (Shadow and Bone), Ann Skelly (The Nevers), Seamus O’Hara (Blue Lights), Michael McElhatton (Game of Thrones), David Wilmot (Station Eleven), Michael Colgan (Say Nothing), Jessica Reynolds (Kneecap), Hilda Fay (The Woman in The Wall), and Elizabeth Daulau (Andor).

    From Kudos (part of Banijay U.K.) and Nebulastar, House of Guiness is executive produced by Karen Wilson, Elinor Day, Steven Knight, Martin Haines, Tom Shankland, and Ivana Lowell, and produced by Cahal Bannon and Howard Burch. Tom Shankland and Mounia Akl split the directing duties.

    See below first images from Netflix for House of Guinness.

    James Norton in ‘House of Guinness’.

    Courtesy of Netflix

    ‘House of Guinness’

    Courtesy of Netflix

    Louis Partridge in ‘House of Guinness’.

    Courtesy of Netflix

    ‘House of Guinness’

    Courtesy of Netflix

    ‘House of Guinness’

    Courtesy of Netflix

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  • What’s the difference between a llama and an alpaca?

    What’s the difference between a llama and an alpaca?

    It’s easy to mistake llamas and alpacas for each other: Both are slender fluffy four-legged mammals with long necks that live in herds. So what’s the difference between these two species?

    “That is the most common question the public asks us,” Rebecca Gill, co-owner of Cotton Creek Farms, a Michigan farm that is home to both animals, told Live Science.

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  • Today’s famous birthdays list for August 18, 2025 includes celebrities Edward Norton, Christian Slater

    Today’s famous birthdays list for August 18, 2025 includes celebrities Edward Norton, Christian Slater

    Birthday wishes go out to Edward Norton, Christian Slater and all the other celebrities with birthdays today. Check out our slideshow below to see photos of famous people turning a year older on August 19th and learn an interesting fact about each of them.

    Top celebrity birthdays on August 19, 2025

    American retired actor, director and producer Robert Redford attends Pope Francis weekly general audience, in St. Peter’s Square, at the Vatican, Wednesday, Dec. 4, 2019. (AP Photo/Andrew Medichini)AP

    Actor and director Robert Redford turns 89

    Fun fact: His son James was also a producer and director before his passing.

    Denis Leary, Roy Wood Jr.
    Comedians Denis Leary, left, and Roy Wood Jr. attend the Michael J. Fox Foundation benefit gala “A Funny Thing Happened on the Way to Cure Parkinson’s” at Casa Cipriani on Saturday, Nov. 16, 2024, in New York. (Photo by Andy Kropa/Invision/AP)Andy Kropa/Invision/AP

    Actor Denis Leary turns 68

    Fun fact: Most recently appeared on the new series “Going Dutch.”

    Christian Slater
    Christian Slater attends the Paramount+ world premiere of “Dexter: Resurrection” at Alice Tully Hall on Wednesday, July 9, 2025, in New York. (Photo by Evan Agostini/Invision/AP)Evan Agostini/Invision/AP

    Actor Christian Slater turns 56

    Fun fact: Slater was cast in the film adaptation of “Interview with the Vampire” after the untimely death of River Phoenix.

    Shauna Robertson, left, and Edward Norton
    Shauna Robertson, left, and Edward Norton pose for photographers upon arrival at the premiere of the film ‘Highest 2 Lowest’ at the 78th international film festival, Cannes, southern France, Monday, May 19, 2025. (AP Photo/Natacha Pisarenko)Natacha Pisarenko/Invision/AP

    Actor Edward Norton turns 56

    Fun fact: His most recent Oscar nomination came this year for portraying Pete Seeger in the film “A Complete Unknown.”

    Josh Horowitz, from left, Andy Samberg, and Mike Judge
    Josh Horowitz, from left, Andy Samberg, and Mike Judge attend the Comedy Central Adult Animation: “South Park,” “Beavis & Butt-Head,” and “Digman!” panel during Comic-Con International on Thursday, July 24, 2025, in San Diego. (Photo by Richard Shotwell/Invision/AP)Richard Shotwell/Invision/AP

    Actor Andy Samberg turns 47

    Fun fact: His middle name is David.

    Maia Mitchell and Josh Heuston
    Maia Mitchell and Josh Heuston arrive for the Boss Spring Summer 2025 fashion show, that was presented in Milan, Italy, Wednesday, Sept. 18, 2024. (AP Photo/Antonio Calanni).AP

    Actress Maia Mitchell turns 32

    Fun fact: Was part of the cast of the horror film “Until Dawn” which was released earlier this year.

    Madelaine Petsch
    Madelaine Petsch poses for a portrait to promote “The Strangers – Chapter 2” during Comic-Con International on Thursday, July 24, 2025, in San Diego. (AP Photo/Chris Pizzello)Chris Pizzello/Invision/AP

    Actress Madelaine Petsch turns 31

    Fun fact: She’s originally from the Seattle area.

    More celebrities with birthdays today

    Actor Henry G. Sanders (“Dr. Quinn, Medicine Woman”) is 83. Drummer Dennis Elliott (Foreigner) is 75. Comedian Elayne Boosler is 73. Country singer Steve Wilkinson of The Wilkinsons is 70. Actor Madeleine Stowe is 67. TV news anchor Bob Woodruff is 64. Actor Adam Storke (“Mystic Pizza”) is 63. Actor Craig Bierko (“Sex and the City,” ″The Long Kiss Goodnight”) is 61. Singer Zac Maloy of The Nixons is 57. Musician Everlast (House of Pain) is 56. Rapper Masta Killa of Wu-Tang Clan is 56. Actor Kaitlin Olson (“The Mick,” ″It’s Always Sunny in Philadelphia”) is 50. Guitarist Brad Tursi of Old Dominion is 46. Actor Parker McKenna Posey (“My Wife and Kids”) is 30.

    Other popular or historical birthdays on August 18th

    • Antonio Salieri, composer
    • Meriwether Lewis, explorer (Lewis & Clark)
    • Shelly Winters, actress
    • Roberto Clemente, MLB outfielder
    • Patrick Swayze, actor

    with The Associated Press

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  • 'House Of Guinness' Sets Premiere Date On Netflix; First-Look Images – Deadline

    'House Of Guinness' Sets Premiere Date On Netflix; First-Look Images – Deadline

    1. ‘House Of Guinness’ Sets Premiere Date On Netflix; First-Look Images  Deadline
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  • Cancer Immunotherapy Advances via RNA Splicing

    Cancer Immunotherapy Advances via RNA Splicing


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    A new study, led by researchers at Children’s Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues. Preclinical research indicates that these missing RNA fragments can make difficult-to-treat tumors more responsive to immunotherapy. The findings were recently published in the journal Cell Reports.

    One of the biggest challenges facing cancer research is the need to find safe and effective therapies for the most aggressive types of brain tumors. Adoptive immunotherapies with CAR-T cells are promising; however, they often also target healthy cells, which share most surface proteins with cancerous cells. While this collateral damage might be tolerable in patients with certain types of blood cancer, in the brain, wiping out healthy neurons is unacceptable. This means that deep knowledge of gene expression patterns exclusive to tumor cells is critical.

    A potential means of discovering new therapeutic targets for brain tumors may lie in alternative splicing, a process whereby a single gene produces multiple proteins by rearranging exons, the building blocks of messenger RNA, in different combinations. Researchers suspected that splicing in glioma cells may differ from splicing in normal brain cells, which could help devise new therapeutic interventions.

    In this study, researchers found that prior RNA sequencing analyses of high-grade gliomas failed to account for some very short exons called “microexons.” Deeper analysis revealed that in glioma, many of these microexons fail to be incorporated into messenger RNAs encoding important surface proteins, including the neuronal cell adhesion molecule known as NRCAM. For normal brain cells to make close contacts known as synapses, full-length NRCAM is needed, but in pediatric high-grade gliomas, two NRCAM microexons were consistently skipped, resulting in a distinct protein structure with unknown function.

    When studying these microexons in more detail, the researchers found that the shortened version of NRCAM generated through microexon skipping was essential for cancer cell migration and invasion in Petri dishes and for tumor growth in a preclinical mouse model implanted with glioma cells. This makes the glioma-specific version of NRCAM an especially attractive immunotherapy target because the tumors won’t be able to shut it down easily.

    “While microexons may be small, the effects they have on the overall protein structure are quite profound,” said senior study author Andrei Thomas-Tikhonenko, PhD, chief of the Division of Cancer Pathobiology at CHOP and Professor of in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine of the University of Pennsylvania. “Because the skipping of NRCAM microexons profoundly changes protein conformation, we were able to develop a mouse monoclonal antibody against the glioma-specific version of NRCAM. When mixed with glioma cells, the antibody worked like a highlighter, “painting” glioma cells and marking them for killing by T cells armed with an immune receptor for mouse antibodies.”

    “In addition to developing these immune receptors clinically, we are actively using our proof-of-principle experiments to design traditional CAR T cell-based immunotherapeutics that selectively target glioma cells,” said first study author Priyanka Sehgal, PhD, a research scientist in the Thomas-Tikhonenko laboratory at CHOP. “This could also change the way we find new targets in other solid tumors.”

    The next steps for this work will be to expand preclinical research and identify a specific form of immunotherapy that could potentially be explored in a clinical trial. The researchers also noted that similar molecular mechanisms have been observed in other tumors such glioblastoma multiforme and cancers of neuroendocrine origin, which also could be targeted with NRCAM-directed immunotherapeutics.

    Reference: Sehgal P, Naqvi AS, Higgins M, et al. NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas. Cell Reports. 2025;44(8). doi: 10.1016/j.celrep.2025.116099

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