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  • Jack Draper out of Wimbledon in second round as Marin Cilic’s grass pedigree triumphs

    Jack Draper out of Wimbledon in second round as Marin Cilic’s grass pedigree triumphs

    THE ALL ENGLAND CLUB, LONDON — For Jack Draper, Wimbledon remains a conundrum. The great home hope fell in the second round on No. 1 Court for a second straight year, this time losing 6-4, 6-3, 1-6, 6-4 against the world No. 83 and former finalist Marin Čilić.

    Those two early exits bookend an otherwise very impressive 12 months of Grand Slam performances for the world No. 4, with runs to the semifinals at the U.S. Open and then fourth-round appearances in Melbourne and Paris.

    It would be easy to attribute his Wimbledon defeats to the strain of being Britain’s highest-ranked player — pressure Draper has continually played down — but like last year’s defeat to Cameron Norrie, Draper again struggled to impose his game on home turf. Normally so nimble, Draper has looked a little heavy-legged here, as though not quite sure yet how to best maneuver his bulky 6 feet 4 inches (193 cm) frame across the grass.

    Čilić, 36, is fresh from winning an ATP Challenger title in Nottingham and knows the intricacies of this surface. He reached the Wimbledon final in 2017 and won the prestigious warm-up tournament at Queen’s in 2012 and 2018. He displayed all of that grass-court pedigree against Draper, dominating from the baseline and neutralizing Draper’s power. His stronger wing is his backhand, which caused Draper a big problem. The Brit’s favored serve from the ad court swings out to the right-hander’s backhand, and it’s generally a devastating weapon. Not so against Čilić, who could handle it with his favorite shot, winning the first set with a return winner off his backhand.

    Čilić’s forehand is much more up and down, but when it works, it can be lethal. It flew through the court at times here, augmented by a brilliant serving display that took in 16 aces and an 88 percent win-rate on first-serve points in the first two sets. Most importantly, Čilić was able to get on the front foot. In the first couple of sets, he spent 25 percent and then 28 percent of the time in attack, compared to 16 percent in both for Draper — a huge drop-off from his average in the past year of 26 percent.

    Draper flipped this in the third set, when it felt as though the momentum of the match might be about to turn. He finally broke for the first time and then raced away with the set, harnessing the energy of a crowd who enjoyed seeing their adversary for the day getting a time violation down break point.

    Čilić wasn’t rattled by the home fans getting on his back. He refocused and got back on the front foot, attacking in 27 percent of the fourth set compared to Draper’s 21 per cent. His movement was impressive too — even when he was younger, before two knee operations, he rarely chased down drop shots like he did against Draper. Čilić’s injuries have been so persistent that this summer’s tournament is his first Wimbledon appearance since 2021.

    Draper clung on to save two break points down 3-4, but a few games later, it was all over. Čilić forced a missed backhand to claim a memorable victory that further opens up a tournament defined by upsets on the men’s and women’s sides. Novak Djokovic, the seven-time champion, and Jakub Menšík, the world No. 17, are the two highest seeds left in Draper’s quarter.

    For Čilić, it is a statement win after fearing that his career would be over following a second knee operation in May last year.

    Draper will be monumentally disappointed, but he has made great strides in so many areas over the past year. He has climbed up from No. 40 to become a fixture in the world’s top five, winning a Masters 1,000 title, the level just below Grand Slams, along the way.

    Until next year at least, this home major continues to be his kryptonite.

    (Photo: Hannah Peters / Getty Images)

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  • NIH Study Links Particulate Air Pollution to Increased Mutations in Lung Cancers Among Nonsmokers

    NIH Study Links Particulate Air Pollution to Increased Mutations in Lung Cancers Among Nonsmokers

    Scientists at the National Institutes of Health (NIH) and their colleagues at the University of California, San Diego, have found that fine-particulate air pollution, which includes pollution from vehicles and industry, was strongly associated with increased genomic changes in lung cancer tumors among people who have never smoked.

    By assembling the largest-ever whole-genome analysis of lung cancer in individuals who have never smoked, researchers were able to link air pollution exposure to increased cancer-driving and cancer-promoting genetic mutations. This could potentially lead to more prevention strategies for never-smokers.

    Researchers analyzed lung tumors from 871 never-smoker patients across 28 geographic locations worldwide as part of the Sherlock-Lung study They found associations between air pollution exposure and changes in the TP53 gene, and other genetic mutational signatures previously associated with tobacco smoking. They also observed a relationship between air pollution and shorter telomeres, which are sections of DNA found at the end of chromosomes. Telomeres shorten naturally with age and shorter telomeres are related to cells inability to continue to replicate. However, scientists found fine particulate air pollution was linked to premature shortening of telomeres.

    Prior genomic studies of lung cancer have focused on tobacco smokers, leaving a significant gap in our understanding of how lung cancer develops in people who have never used tobacco. By beginning to uncover the mechanisms through which tissues acquire cancer-causing or cancer-promoting mutations following environmental exposures, this study helps scientists better understand the primary drivers of lung cancer in this population—which represents up to 25% of all lung cancer cases globally.

    Interestingly, the researchers found that while exposure to secondhand smoke was associated with slightly higher mutation burdens and shorter telomeres, compared to tumors in patients who were not exposed, it did not lead to an increase in cancer-driving mutations or mutational signatures. This suggests that secondhand smoke may have a lower overall ability to cause genetic mutations, known as mutagenicity, compared to air pollution.

    This work was led by researchers at NIH’s National Cancer Institute and the University of California, San Diego, and published in Nature on July 2, 2025.

    This news release was published by the National Institutes of Health on July 2, 2025.

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  • Hepatitis E virus also attacks organs other than the liver, study finds

    Hepatitis E virus also attacks organs other than the liver, study finds

    A research team from Bochum and Hannover shows that the hepatitis E virus also attacks organs other than the liver.

    The hepatitis E virus (HEV) causes severe liver inflammation. A research team from Ruhr University Bochum, Germany, and TWINCORE, the Centre for Experimental and Clinical Infection Research in Hannover, has now been able to prove for the first time that it can also infect kidney cells and replicate there. Antiviral drugs such as ribavirin are less effective there than in the liver. The results of the study have now been published in the journal Liver International on June 27, 2025.

    Entire life cycle possible in the kidney

    Hepatitis E viruses mainly infect liver cells and cause the most damage in the liver. “However, it was already known that they can go down the wrong path and infect other cells, such as nerve cells,” says last author Dr. André Gömer from the Department of Molecular and Medical Virology at Ruhr University Bochum.

    The team from Bochum and Hannover has now succeeded in proving in cell culture that the viruses also infect kidney cells and can multiply with their help. “The entire replication cycle of the virus takes place in kidney cells in the same way as in liver cells,” says Gömer.

    The infected kidney cells responded less well to treatment with the antiviral drug ribavirin than the liver cells. “This is probably due to the significantly different metabolic profiles of the two organs,” says Gömer. In the kidney, the virus is therefore relatively insensitive to drug treatment.

    “It could be that in chronic infections, the kidney acts as a reservoir from which the viruses spread again after a supposedly successful treatment,” says Nele Meyer, a PhD student in the Translational Virology research group at TWINCORE. She and the physician Avista Wahid are the first authors of the study. Such a reservoir could also enable the viruses to adapt better to treatment.

    Evolution in the organ

    The team also conducted a comparative genetic analysis of hepatitis viruses from chronically infected patients using their blood plasma, stool and urine. While viruses are mainly excreted from the liver in the stool, those from the kidneys are found in the urine. ‘The viruses found in the different samples differ significantly from each other,” reports Dr Patrick Behrendt, head of the Translational Virology group at TWINCORE and also last author of the article. “This indicates that the populations have been developing independently of each other for some time and have undergone a kind of evolution in the respective organ.”

    The hepatitis E virus

    The hepatitis E virus (HEV) is the main cause of acute viral hepatitis. After the first documented epidemic outbreak in 1955 to 1956, more than 50 years passed before researchers began to focus intensively on the topic. Acute infections normally heal themselves in patients with an intact immune system. In patients with a reduced or suppressed immune system, such as organ transplant recipients or HIV-infected patients, HEV can become chronic. HEV is also particularly dangerous for pregnant women.

    Funding

    The work was supported by the German Center for Infection Research, the Volkswagen Foundation, the German Research Foundation (398066876/GRK 2485/2 and 448974291) and the Federal Ministry of Education and Research (VirBio project, funding code: 01KI2106).

    Source:

    Journal reference:

    Wahid, A., et al. (2025). Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney. Liver International. doi.org/10.1111/liv.70183.

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  • NDMA issues new alert for heavy rain, storms across country

    NDMA issues new alert for heavy rain, storms across country

    Listen to article


    ISLAMABAD:

    The National Disaster Management Authority (NDMA) has issued a nationwide weather alert, warning of heavy rain, thunderstorms, and the possibility of flooding across Pakistan from July 6 to July 10.

    According to the NDMA, cities in provinces will experience significant weather disturbances. Islamabad, Rawalpindi, Attock, Jhelum, Chakwal, Mianwali, Sargodha, Khushab, Gujranwala, Gujrat, Faisalabad, Lahore, Kasur, and Okara are expected to see rain accompanied by gusty winds and thunderstorms.

    In southern Punjab, heavy winds with rain are predicted in Multan, Khanewal, Bahawalpur, Bahawalnagar, Rahim Yar Khan, and Dera Ghazi Khan.

    Khyber-Pakhtunkhwa is also at risk, with regions like Dera, Swat, Chitral, Kohistan, Shangla, Buner, Battagram, Swabi, Nowshera, Charsadda, Malakand, Mansehra, Abbottabad, Peshawar, Mardan, Haripur, Bannu, and Kohat likely to see thunderstorms and heavy rain.

    In the northern areas of Gilgit-Baltistan, heavy rainfall is anticipated in Skardu, Hunza, Astore, Diamer, Ganche, Shigar, Muzaffarabad, Neelum Valley, Rawalakot, Haveli, and Bagh, with a high risk of flooding in these regions.

    Meanwhile, the provinces of Sindh and Balochistan are not exempt from adverse weather conditions. Cities such as Sukkur, Nawabshah, Kashmore, Hyderabad, Karachi, Tharparkar, Mirpur Khas, Umerkot, Sanghar, Jamshoro, Tando Allahyar, Thatta, Badin, Mithi, Ghotki, Khairpur, Shikarpur, Larkana, Jacobabad, and Dadu are expected to receive heavy rain, with the urban flooding expected.

    In Balochistan, areas like Quetta, Zhob, Ziarat, Kalat, Khuzdar, Awaran, Barkhan, Jafarabad, Kohlu, Sibi, Dera Bugti, Loralai, Lasbela, and Naseerabad are on alert for rainfall.

    Read More: Flash floods, heavy rain kill 64 in a week

    The NDMA has cautioned the public to stay away from weak structures, brick walls, electric poles, and billboards during storms and heavy winds, as they pose a significant risk.

    It also warned that visibility could be reduced, leading to potential accidents. Flash floods may occur, especially in local streams, so the public is advised to exercise caution.

    “Authorities have been instructed to ensure preparedness for any emergency situations,” an NDMA spokesperson said. “Citizens are encouraged to use the Pak NDMA Disaster Alert App for updates and guidance on the weather conditions and potential hazards.”

    As Pakistan braces for severe weather, the NDMA is urging citizens to stay informed and follow safety guidelines to minimise the risk of casualties and damage from storms, flooding, and other weather-related hazards.

    Also Read: Construction along Swat River diverted water flow, leading tourists into danger: report

    Flash floods and heavy rain have killed 64 people and injured 117 in a week across the country, a government agency said on Wednesday.

    The highest toll was in K-P, with 23 dead including 10 children, the National Disaster Management Authority said. Fourteen of the victims were swept away in a flash flood in the Swat Valley last week, local media reported.

    Flash floods and homes collapsing in heavy rain killed 21 others in the eastern province of Punjab, including 11 children, the authority said. In Sindh, 15 were killed, while five people died in southwestern Balochistan.

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  • Gulf markets rally as non-oil growth, US-Vietnam tariff deal lift investor sentiment

    Gulf markets rally as non-oil growth, US-Vietnam tariff deal lift investor sentiment

    Major Gulf stock markets rebounded on Thursday, supported by steady non-oil private sector growth and renewed investor optimism following a trade agreement between the United States and Vietnam, just ahead of the July 9 tariff deadline.

    U.S. President Donald Trump signed a deal with Vietnam on Wednesday imposing a 20% tariff on exports to the United States — significantly lower than the previously threatened 46%. The move gave markets reason to hope the impact of the tariffs on global trade may be less severe than initially feared.

    Saudi Arabia’s benchmark index rose 1%, reaching its highest level in over a month, with almost all constituents posting gains. Saudi National Bank, the kingdom’s largest lender by assets, surged 4.1%, while oil giant Saudi Aramco added 0.9%.

    BlackRock Inc. was reportedly in talks with Aramco to divest its stake in the leasing rights of a natural gas pipeline network — a deal potentially worth billions of dollars, according to Bloomberg. Reuters could not independently verify the report.

    Retailer Fawaz Abdulaziz Al Hokair & Co. was the day’s top performer, jumping 9.9%, followed by Saudi Telecom, which rose 1.2%.

    Market optimism was also fueled by strong domestic data. Saudi Arabia’s non-oil private sector expanded at its fastest pace in three months in June, according to a new survey. The seasonally adjusted Riyad Bank Saudi Arabia Purchasing Managers’ Index rose to 57.2 from 55.8 in May, remaining well above the 50-point growth threshold.

    Dubai’s main index gained 1.4% to close at 5,748 — its highest in 17 years — with most sectors trading in positive territory. Emaar Properties climbed 3.7%, while tolls operator Salik advanced 3.4%.

    In Abu Dhabi, the benchmark index rose 0.6%, supported by gains across sectors. Presight AI surged 6%, reaching its highest level in nearly two years, while Space42 rose 4.3%.

    The UAE’s non-oil private sector also expanded steadily in June despite regional tensions, as companies ramped up output to clear backlogs, according to a separate survey released Thursday.

    Qatar’s main index added 0.6%, lifted by a 0.5% gain in Qatar National Bank.

     


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  • Afghanistan National T20 Cup 2025: Pamir Legends vs Mahipar Stars; Hindokush Strikers vs Maiwand Champions

    Afghanistan National T20 Cup 2025: Pamir Legends vs Mahipar Stars; Hindokush Strikers vs Maiwand Champions

    Here are the Fantasy Cricket Predictions and Betting Tips for Afghanistan National T20 Cup 2025, Match 9 – Pamir Legends vs Mahipar Stars and Match 10 – Hindokush Strikers vs Maiwand Champions on the 4th of July at the Kunduz Cricket Ground, Kunduz.

    Points Table

    Match 9 – Pamir Legends vs Mahipar Stars (Kunduz Cricket Ground, Kunduz)

    Current Form Pamir Legends:
    Pamir Legends are currently placed at the 3rd position on points table with 2 wins and 2 losses to their credit.

    The top run scorer for Pamir Legends in the Afghanistan National T20 Cup is Mohammad Haroon with 140 runs to his name.

    The top wicket taker for Pamir Legends in the Afghanistan National T20 Cup is Sayed Shirzad with 7 scalps under his belt.
    Pamir Legends have won their previous match against Maiwand Champions by 3 wickets.

    Maiwand Champions batted first and they posted a total of 163 for 8 in 20 overs. Wasim Akram and Shawkat Zaman got out without troubling the scorers much. After their dismissals, Khalid Taniwal and Abdul Hadi played really well and scored 39 and 50 runs respectively. The rest of the batters failed to perform to their potential and Maiwand Champions had to settle for an ordinary total of 163 in their innings.

    During the chase, Pamir Legends lost their premier batter Mohammad Haroon early on in the innings. After his dismissal, Wafiullah  took the responsibility of taking Pamir Legends over the line. He smashed 76 runs off 39 balls and laid out a great foundation for a successful chase. There were hiccups on the way but Pamir Legends chased the target down in the last over with 3 wickets in hand.

    Batting Stats T20

    Current Form Mahipar Stars:

    Mahipar Stars are currently placed at the 2nd position on points table with 2 wins and 2 losses to their credit.

    The top run scorer for Mahipar Stars in the Afghanistan National T20 Cup is Mohammad Shahzad with 131 runs to his name.

    The top wicket taker for Mahipar Stars in the Afghanistan National T20 Cup is Saleem Safi with 8 scalps under his belt.
    Mahipar Stars have lost their previous match against Hindokush Strikers by 4 wickets.

    Mahipar Stars batted first and they posted a total of 144 before being bowled out. Hazaratullah Zazai batted well and scored 25 quick runs but he got out at a wrong time. After his dismissal, the whole team struggled. Yama Arab bowled exceptionally well for Hindokush Strikers as he picked up 2 wickets for just 14 runs. He played a major role in bowling Mahipar Stars out for a small total of 144.

    During the chase, Hindokush Strikers got off to a great start. Their openers Mobin Bakhtyar Khan and Zubaid Akbari played like champions and scored 18 and 47 runs respectively. Even after their dismissals at a wrong time, the other middle order batters kept the ship from sinking. Tariq Stanikzai made 27 important runs as Hindokush Strikers won the game on the last ball of the match with 4 wickets in hand.

    Let’s have a look at the squads:

    Mahipar Stars

    Hazratullah Zazai, Mohammad Shahzad, Hamza Khan Alikhil, Usman Sadaat, Naveed Obaid, Shir Khan Bahadur, Allah Noor, Sediq Pacha, Javid Sulaimankhil, Shamsurrahman, Farmanullah Safi, Khalil Gurbaz, Qamar Shams, Mohammad Ibrahim, M Saleem Safi, Aftab Alam, Mohib Zurmatai

    Pamir Legends

    Nangyal Kharoty, Noor Rahman, Murad Muradi, Wafiullah Tarakhil, Haroon Khan, Barakzai Naseri, Bilal Ahmad, Emal Shaheen, Rahmanllah Zadran, Asif Shah, Mohib Hamraz, Mohammadullah, Arab Gul Momand, Lalbaz Sinzai, Sayed Shirzad, Kamil Kakar, Bilal Sami

    Match Prediction – Pamir Legends v Mahipar Stars

    Cricket Betting Tips and Match Predictions* – PrePlay

    Who will win the toss? – Mahipar Stars

    Who will win?– Mahipar Stars

    Top Batter (Runs Scored) – Aaif Shah Khan (Pamir Legends), Hazaratullah Zazai (Mahipar Stars)

    Top Bowler (Wickets taken) – Bilal Sami (Pamir Legends), Khalil Gurbaz (Mahipar Stars)

    Most Sixes – Aaif Shah Khan (Pamir Legends), Hazaratullah Zazai (Mahipar Stars)

    Player of the Match– Hazaratullah Zazai (Mahipar Stars)

    Team Scores Batting first – Pamir Legends 165+, Mahipar Stars 170+

    Match Handicap : Mahipar Stars

    Wicket Takers T20

    Match 10 – Hindokush Strikers vs Maiwand Champions (Kunduz Cricket Ground, Kunduz)

    Current Form Maiwand Champions:

    Maiwand Champions are currently placed at the bottom most position on points table with 4 losses to their credit.

    The top run scorer for Maiwand Champions in the Afghanistan National T20 Cup is Samiullah Shinwari with 93 runs to his name.

    The top wicket taker for Maiwand Champions in the Afghanistan National T20 Cup is Khalel Ahmad with 5 scalps under his belt.
    Maiwand Champions have lost their previous match against Pamir Legends by 3 wickets.

    Maiwand Champions batted first and they posted a total of 163 for 8 in 20 overs. Wasim Akram and Shawkat Zaman got out without troubling the scorers much. After their dismissals, Khalid Taniwal and Abdul Hadi played really well and scored 39 and 50 runs respectively. The rest of the batters failed to perform to their potential and Maiwand Champions had to settle for an ordinary total of 163 in their innings.

    During the chase, Pamir Legends lost their premier batter Mohammad Haroon early on in the innings. After his dismissal, Wafiullah  took the responsibility of taking Pamir Legends over the line. He smashed 76 runs off 39 balls and laid out a great foundation for a successful chase. There were hiccups on the way but Pamir Legends chased the target down in the last over with 3 wickets in hand.

    Current Form Hindokush Strikers:

    Hindokush Strikers are currently placed at the 1st position on points table with 4 wins to their credit.

    The top run scorer for Hindokush Strikers in the Afghanistan National T20 Cup is Zubaid Akbari with 133 runs to his name.

    The top wicket taker for Hindokush Strikers in the Afghanistan National T20 Cup is Dawlat Zadran with 6 scalps under his belt.

    Hindokush Strikers have won their previous match against Mahipar Stars by 4 wickets.

    Mahipar Stars batted first and they posted a total of 144 before being bowled out. Hazaratullah Zazai batted well and scored 25 quick runs but he got out at a wrong time. After his dismissal, the whole team struggled. Yama Arab bowled exceptionally well for Hindokush Strikers as he picked up 2 wickets for just 14 runs. He played a major role in bowling Mahipar Stars out for a small total of 144.

    During the chase, Hindokush Strikers got off to a great start. Their openers Mobin Bakhtyar Khan and Zubaid Akbari played like champions and scored 18 and 47 runs respectively. Despite their dismissals at wrong time, the other middle order batters kept the ship from sinking. Tariq Stanikzai made 27 important runs as Hindokush Strikers won the game on the last ball of the match with 4 wickets in hand.

    Most 6’s T20

    Let’s have a look at the squads:

    Hindokush Strikers
    Mohammad Ishaq, Mobin Khan, Zubaid Akbari, Hassan Esakhil, Kamal Khan, Asif Mosazai, Ijaz Ahmadzai, Sohail Khan, Tariq Stanikzai, Abdullah Tarakhil, Izharulhaq Naveed, Azeem Zadran, Lutfullah, Abdullah Ahmadzai, Dawlat Zadran, Yama Arab, Faridoon Dawoodzai

    Maiwand Champions

    Najibullah Zadran, Yousaf Shah, Abdul Hadi, Mohammad Akram, Khalid Taniwal, Imran Mir, Shawkat Zaman, Ijaz Ahmad, Samiullah Shinwari, Ismat Alam, Babar Khan, Naseer Maroofkhil, M Gul Alizai, Khalil Ahmad, M Dawood, Sami Sarmast, Bashir Ahmad

    Match Prediction – Hindukush Strikers v Maiwand Champions

    Cricket Betting Tips and Match Predictions* – PrePlay

    Who will win the toss? – Maiwand Champions

    Who will win?– Hindokush Strikers

    Top Batter (Runs Scored) – Zubaid Akbari (Hindokush Strikers), Abdul Hadi (Maiwand Champions)

    Top Bowler (Wickets taken) – Yama Arab (Hindokush Strikers), Mohammad Gul Alizai (Maiwand Champions)

    Most Sixes – Zubaid Akbari (Hindokush Strikers), Abdul Hadi (Maiwand Champions)

    Player of the Match– Yama Arab (Hindokush Strikers)

    Team Scores Batting first – Maiwand Champions 140+, Hindokush Strikers 150+

    Match Handicap : Hindokush Strikers

    Live Cricket Streaming Afghanistan National T20 Cup 2025 : The live cricket streaming page which enables you to watch live cricket  – Geo-restrictions apply

    *NB these predictions may be changed nearer the start of the match once the final starting teams have been announced and we will be running ‘In-Play’ features, so stay tuned.

    © Cricket World 2025
     

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  • Lando Norris reflects on his Silverstone chances and why he and Piastri are doing things their ‘own way’

    Lando Norris reflects on his Silverstone chances and why he and Piastri are doing things their ‘own way’

    A roar reverberates around Trafalgar Square as Lando Norris comes into view on a temporary balcony, erected as part of McLaren’s takeover of one of London’s most famous sites.

    The place is swarming with papaya fans, who have spent the day soaking up the summer sun and showing their support for the British team.

    Norris waves to the crowd and humbly takes the applause and cheers. It’s an example of just how far Norris has come from a shy, little baby-faced teenager who walked in the doors of McLaren’s domineering headquarters in Woking as a junior driver in 2017 to the iconic F1 team’s lead driver and genuine championship contender. It’s been a journey – and now, as is evidenced again today, he’s a big deal.

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  • Long-term study confirms lasting benefits of lifestyle changes in preventing diabetes

    Long-term study confirms lasting benefits of lifestyle changes in preventing diabetes

    In the early 2000s the U.S. Diabetes Prevention Program (DPP), a large randomized clinical trial, showed that intensive lifestyle modification was better than a medication called metformin at preventing at-risk patients from developing Type 2 diabetes.

    In a newly completed follow-up study, a team of researchers including Vallabh “Raj” Shah, professor emeritus in The University of New Mexico Departments of Internal Medicine and Biochemistry & Molecular Biology at the School of Medicine, found that the health benefits from the lifestyle intervention persisted more than 20 years later.

    In a paper published in The Lancet Diabetes & Endocrinology, they reported that the greatest results from both interventions were seen in the first few years of the study, and they were durable, Shah said. “The data suggests that those people who didn’t get diabetes also didn’t get diabetes after 22 years,” he said.

    The DPP was launched in 1996 to compare the benefits of metformin – then newly approved by the FDA to treat Type 2 diabetes – and a lifestyle modification regimen that included exercise and a healthy diet. The study enrolled 3,234 patients with prediabetes at 30 institutions in 22 states.

    The intensive lifestyle intervention reduced the development of diabetes by 24%, and metformin reduced diabetes development by 17%, according to the new study. The DPP had previously found that after the first three years of study, the lifestyle intervention of moderate weight loss and increased physical activity reduced the onset of Type 2 diabetes by 58% compared with a placebo medicine, while metformin reduced development of diabetes by 31%.

    Compared with the original placebo group, the median time without diabetes was extended by three-and-a-half years in the lifestyle group and two-and-a-half years in the metformin group.

    Within three years, they had to stop the study because lifestyle was better than metformin. That means lifestyle, which everybody is banking on, is more effective – that is the news.”


    Vallabh “Raj” Shah, professor emeritus in The University of New Mexico

    But because a wealth of health and biological data had already been collected for patients participating in the project, the DPP was repurposed into the DPP Outcomes Study (DPPOS), enabling researchers to follow their health outcomes in multiple domains over a period of decades, he said.

    Shah has contributed to kidney disease research for more than three decades, conducting multiple studies at Zuni Pueblo and other American Indian communities in western New Mexico. He has also overseen the participation of the American Indian cohort enrolled in the DPPOS. Meanwhile, David Schade, MD, chief of the Division of Endocrinology in the UNM School of Medicine, recruited New Mexico participants in the study.

    More recently, he said, DPPOS researchers have taken advantage of their large, well-documented cohort to repurpose the study to focus on diseases associated with aging, such as cancer and dementia, Shah said.

    Source:

    University of New Mexico Health Sciences Center

    Journal reference:

    Knowler, W. C., et al. (2025). Long-term effects and effect heterogeneity of lifestyle and metformin interventions on type 2 diabetes incidence over 21 years in the US Diabetes Prevention Program randomised clinical trial. The Lancet Diabetes & Endocrinology. doi.org/10.1016/s2213-8587(25)00022-1.

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  • Kanye West’s Australian visa revoked over ‘Heil Hitler’ song

    Kanye West’s Australian visa revoked over ‘Heil Hitler’ song

    Ye, formerly known as Kanye West, will no longer be able to enter Australia after releasing a song that praises Nazi leader Adolf Hitler.

    Tony Burke, Australia’s home affairs minister, told the Australian Broadcasting Corp. on Wednesday that the country had canceled his visa in early May, around the time “Heil Hitler” was released.

    Ye has visited the country frequently since marrying Bianca Censori, who is from Melbourne.

    “If someone argued that antisemitism was rational, I would not let them come here,” Burke said. “[Ye] has been coming to Australia for a long time … and he’s made a lot of offensive comments.”

    The song proved to be the final strike for Ye. First shared in a social media post on X, “Heil Hitler” as been widely denounced for its racial epithets and antisemitism. It was also subsequently banned on most streaming platforms.

    In the song, Ye sampled an infamous speech made by Hitler in 1935 at Krupp Factory, two years after he was appointed chancellor of the Nazi party.

    Its music video, released May 8, shows a group of individuals dressed in animal skins reciting the song’s lyrics.

    Ye’s behavior has long been controversial, but his antisemitism in recent years has put former colleagues in an awkward position.

    John Legend, whose 2013 effort “Love in the Future” was executive produced by Ye, had a clear response in a recent interview.

    “It never affects me personally, but just the whole story is sad. Like, seeing this guy praise Hitler, seeing this guy be this force of hate and just vitriol and nastiness,” Legend said during an appearance on New York’s Hot 97 radio show. “All the things he’s done to make the world more beautiful and interesting, for him to be this now, it’s sad. It’s just sad.”

    He clarified that during his time on Ye’s G.O.O.D. Music label between 2004 and 2016, he never saw evidence that the rapper was “obsessed with Hitler.”

    Legend added that despite Ye’s recent behavior, he has no regrets over their past collaborations: “I’m so glad we did what we did together.”

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  • B&B Cocktail from Homemade Live

    B&B Cocktail from Homemade Live

    On Episode One of Season Three of Homemade Live, Chef Joel Gamoran visits with legendary chef and TV host, Lidia Bastianich. Building on the versatility of turkey, Chef Gamoran makes a B&B cocktail that features turkey broth.

    Serves 2

    INGREDIENTS

    ● 1 cup turkey broth (homemade or low-sodium for best flavor)
    ● 3 ounces bourbon
    ● 2 dashes Worcestershire sauce (choose a rich, flavorful brand)
    ● 2 dashes vinegar-based hot sauce
    ● ½ teaspoon fresh lemon juice
    ● 1 pinch cayenne pepper (optional, for spice)
    ● Wheels of lemon, fresh ginger, or pickled vegetables for garnish, as desired

    TO PREPARE

    STEP ONE. Warm the turkey broth in a small saucepan over low heat until just warm to the touch.

    STEP TWO. Add 1½ oz bourbon to each mug and top with with Worcestershire sauce, hot sauce, celery salt, lemon juice, and cayenne (if using).

    STEP THREE. Add ½ cup of warm broth to the mug and stir.  Garnish as you wish.


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