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  • Halo: Campaign Evolved: Release date rumors, platforms, and everything else we know about the Halo remake

    Halo: Campaign Evolved: Release date rumors, platforms, and everything else we know about the Halo remake

    25 years after Halo: Combat Evolved launched, Microsoft and Xbox Game Studios are planning to refresh the original sci-fi first-person shooter for franchise veterans and the younger gamers alike. Enter Halo: Campaign Evolved, a ground-up remake…

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  • Pfizer execs talk Metsera obesity drug

    Pfizer execs talk Metsera obesity drug

    Albert Bourla, chairman and CEO of Pfizer, speaks at The Wall Street Journal’s Future of Everything Festival in New York City, U.S., May 22, 2024. 

    Andrew Kelly | Reuters

    A version of this article first appeared in CNBC’s Healthy Returns newsletter, which brings the latest health-care news straight to your inbox. Subscribe here to receive future editions.

    Pfizer made one thing clear this week: It’s officially back in the obesity race. 

    The drugmaker is laser-focused on bringing to market treatments from its $10 billion acquisition of the obesity biotech Metsera. On Tuesday, it released promising phase two trial data on one injection, called PF′3944, that’s furthest along in development. 

    The experimental drug drove solid weight loss when taken once a month in a mid-stage trial – offering early evidence that the injection can be administered less frequently than existing drugs without sacrificing efficacy. That could be a boon to Pfizer after it faced several setbacks in trying to win a slice of a market dominated by weekly injections from Eli Lilly and Novo Nordisk, along with Novo’s new daily pill. 

    Patients with obesity or who are overweight lost up to 12.3% of their weight compared with placebo at week 28 in the ongoing phase two study. The company said no plateau was observed after patients transitioned to monthly dosing, which suggests that continued weight loss is expected as the study continues through week 64.

    But investors are still looking for the full data from that trial, which is slated to be presented at a medical conference in June. Pfizer also plans to start 10 phase three studies on the injection, with the goal of achieving the first of several potential approvals in 2028. 

    I talked to Pfizer CEO Albert Bourla and other top execs about the data this week and the company’s broader obesity strategy. Here’s what they had to say.

    A potential “best-in-class” product 

    Bourla told CNBC that the data shows the monthly product has a “very competitive profile in tolerability and efficacy.” 

    Pfizer plans to use a higher dose of the drug in phase three trials, and Bourla said it will produce efficacy and tolerability data that is “maybe best in class, so better than anything else,” while being taken less frequently. The company’s modeling predicts that the higher dose could result in 16% weight loss at week 28.

    In the phase two trial, patients started on weekly injections of the drug for 12 weeks before switching to once-monthly dosing. 

    Pfizer also plans to study people who are taking existing weekly GLP-1s and give them the option to switch to the company’s monthly shot, said Dr. Jim List, Pfizer’s chief internal medicine officer. 

    List said that’s one of the selling points of the company’s injection: it can serve as a more convenient maintenance treatment for patients to switch to. 

    “If you say, listen, I can give you one of these drugs. This one, you’ll take once a week for the rest of your life. But this other one, you’ll take once a week, and you could also switch it to once a month. Which one do you want?” List said. “It’s always going to be the one with more options. 

    He added that “weekly doesn’t work for everybody,” since some patients need to travel and can’t keep their injections refrigerated.

    Bourla said people who have been taking weekly injections are also more likely to switch to another shot rather than an oral option. 

    “The oral will be for people, but they didn’t start with the needle,” he said. “So as a result, I think the monthly or longer products will probably become a standard, and we are the first and hopefully the best.” 

    Combination regimens

    A key part of Pfizer’s strategy for the PF′3944 injection is to combine it with another drug targeting a gut hormone called amylin, List said. 

    “We’re expecting to get even more weight loss with that combination than we get with this GLP-1 alone,” he said. 

    Amylin is hormone co-secreted with insulin in the pancreas to suppress appetite and reduce food intake. Amylin treatments have a similar effect to GLP-1s like Lilly’s Zepbound and Mounjaro, but some analysts and researchers say it could be easier for patients to tolerate and help them preserve lean muscle mass. 

    Pfizer on Tuesday said early data showed that the two drugs together caused an additive weight loss of 5% when compared to placebo at day 8. Amylin alone also showed weight loss of 8.4% at day 36.  

    Both drugs are ultra-long-acting, meaning they are engineered to remain active in the body for longer than existing treatments like Novo’s Wegovy and can be taken once a month. 

    Pfizer plans to share more data on the amylin drug during the medical conference in June. List said the company is advancing the product into phase two trials in the first half of this year. 

    Quarterly dose GLP-1 injection 

    Pfizer on Tuesday also teased a potential GLP-1 injection that is dosed quarterly – once every three months – rather than monthly or weekly. 

    List said the injection will be “ultra-ultra-long-acting,” so Pfizer will be finding a way for the drug to have “slower degradation in the human body so that it can certainly last longer” than PF′3944.

    Chief Scientific Officer Chris Boshoff told CNBC that the vast majority of patients will prefer an injection, and “obviously, being monthly will be preferable over weekly, and likely three-monthly maybe better than monthly.”

    But List said it’s still early days for that drug.

    Feel free to send any tips, suggestions, story ideas and data to Annika at a new email: annika.constantino@versantmedia.com.

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  • NASA space telescope sees interstellar visitor comet 3I/ATLAS flare up while exiting the solar system

    NASA space telescope sees interstellar visitor comet 3I/ATLAS flare up while exiting the solar system

    New infrared observations reveal the rare interstellar visitor comet 3I/ATLAS dramatically brightening during its farewell tour of the solar system.

    NASA’s SPHEREx (Spectro-Photometer for the History of the Universe, Epoch of Reionization and…

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  • Margie Jamieson to present photos from Mongolia at Have Camera, Will Travel

    Margie Jamieson to present photos from Mongolia at Have Camera, Will Travel

    Margie Jamieson to present photos from Mongolia at Have Camera, Will Travel

    Published 11:30 am Friday, February 6, 2026

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  • UN warns of abuse of Palestinians returning to Gaza through Rafah crossing – Arab News PK

    UN warns of abuse of Palestinians returning to Gaza through Rafah crossing – Arab News PK

    1. UN warns of abuse of Palestinians returning to Gaza through Rafah crossing  Arab News PK
    2. Palestinian women recount ‘journey of horror’ at Gaza’s Rafah crossing  Al Jazeera
    3. Israel subjects Gaza returnees to abuse, coercion and humiliation at…

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  • Page Not Found – Streaming Media

    Page Not Found

    Thank you for visiting StreamingMedia.com!

    Unfortunately, we are unable to locate the page you requested.

    The page may have moved or may no longer be available.

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  • 25 Years Ago, Thom Browne’s Suits Changed Menswear Forever. They Still Look Radical

    25 Years Ago, Thom Browne’s Suits Changed Menswear Forever. They Still Look Radical

    Very few suits alter the course of menswear history. But we’d wager that most guys with even a passing interest in tailoring could identify one of Thom Browne’s paradigm-shifting suits on sight alone.

    Browne introduced his shrunken gray suit…

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  • Microsoft Starts Testing Built-In Sysmon Monitoring in Windows 11 – TechRepublic

    1. Microsoft Starts Testing Built-In Sysmon Monitoring in Windows 11  TechRepublic
    2. List of new features coming to Windows 11 in 2026 (so far), and it’s not just Copilot (AI) stuff  Windows Latest
    3. Microsoft fixes bug causing password sign-in option…

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