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  • Supermassive Black Hole Caught in The Act of Switching on : ScienceAlert

    Supermassive Black Hole Caught in The Act of Switching on : ScienceAlert

    A recent discovery by a team of astronomers centres on a galaxy cluster called CHIPS 1911+4455, located an incredible 6 billion light-years from Earth.

    At its heart lies a supermassive black hole that has only recently ‘turned on’, just a thousand years ago. While that might sound like a long time, it’s merely a blink of an eye in astronomical terms.

    Lead researcher Francesco Ubertosi from the University of Bologna describes the phenomenon as watching a sleeping giant wake up. The team used the Very Long Baseline Array and Very Large Array telescopes to peer deep into space with remarkable precision, imagine being able to read a newspaper in Los Angeles while standing in New York.

    Related: Awakening Black Hole’s Wild Behavior Has Astronomers Stumped

    What makes this black hole special is that it’s essentially a newborn in terms of activity. The jets of material it’s shooting out extend only about 100 light-years from its center.

    While that sounds enormous, it’s actually tiny by black hole standards. Mature black holes in similar systems can create jets stretching for tens of thousands of light-years.

    The ngVLA prototype antenna during the handover ceremony, with the older antennae in the background. (C. Jaramillo Feldman U.S. National Science Foundation/NSF National Radio Astronomy Observatory)

    Most black holes astronomers study have been active for millions of years, making it difficult to understand how they first begin affecting their surroundings. This newly awakened black hole provides a unique ‘before’ picture, showing scientists what happens in the earliest stages of black hole activity.

    “The jets are so young and small that they haven’t had time to push away the surrounding hot gas, this creates a perfect natural laboratory for studying how black holes first begin to influence their cosmic neighbourhood.” – Co-author Myriam Gitti from University of Bologna.

    While the black hole is just waking up, the galaxy around it is anything but sleepy. This galaxy is creating new stars at an astounding rate; between 140 and 190 times the mass of our Sun every single year.

    To put that in perspective, our entire Milky Way Galaxy only forms about one Sun’s worth of stars annually. The researchers believe they may be witnessing the smoking gun of how black holes get triggered in the first place. The hot gas surrounding this black hole is cooling very efficiently, potentially providing the fuel needed to wake up the black hole.

    CHIPS 1911+4455 galaxy cluster
    Hubble image of the galaxy cluster CHIPS1911+4455. (NASA/ESA/Hubble Heritage Team)

    Understanding how supermassive black holes wake up helps solve fundamental questions about how galaxies evolve. These black holes play a crucial role in regulating star formation and shaping the largest structures in the Universe. By catching one in the act of awakening, it’s possible to finally study this process as it unfolds rather than just seeing the end result.

    The discovery required combining observations from multiple telescopes, each providing different pieces of the puzzle. Some offered ultra high resolution to see the tiny jets, while others provided the sensitivity needed to detect faint signals from star formation.

    As the research team continues, they hope to watch how it evolves over time and find more similar systems. This could revolutionise our understanding of how the universe’s most powerful objects first begin to shape the cosmos around them.

    This article was originally published by Universe Today. Read the original article.

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  • New bioimaging device shows promise for detecting eye and heart conditions

    New bioimaging device shows promise for detecting eye and heart conditions

    If you’ve been to a routine eye exam at the optometrist’s office, chances are you’ve had to place your chin and forehead up close to a bioimaging device. 

    It’s known as optical coherence tomography (OCT), and it’s widely used in eye clinics around the world. OCT uses light waves to take high-resolution, cross-sectional images of the retina in a non-invasive manner.

    These images can be essential for diagnosing and monitoring eye conditions. 

    In any bioimaging-either retinal or in-vivo imaging that takes place inside the human body-devices must be quite small and compact to produce high-quality images. 

    However, mechanical aspects of OCT devices, like spinning mirrors, can increase the chance of device failure. 

    Researchers at the University of Colorado Boulder have developed a new bioimaging device that can operate with significantly lower power and in an entirely non-mechanical way. It could one day improve detecting eye and even heart conditions.

    In a recent study published in Optics Express, the team of engineers created a device that uses a process called electrowetting to change the surface shape of a liquid to perform optical functions.

    We are really excited about using one of our devices, in particular for retinal imaging. This could be a critical technique for in-vivo imaging for inside our bodies.” 


    Samuel Gilinsky, lead author, a recent PhD graduate in electrical engineering

    By creating a device that doesn’t use scanning mirrors, the technique requires less electrical power than other devices used for OCT and bioimaging. 

    “The benefits of non-mechanical scanning is that you eliminate the need to physically move objects in your device, which reduces any sources of mechanical failure and increases the overall longevity of the device itself,” Gilinsky said. 

    Gilinsky noted the need for these OCT systems to be compact, lightweight and, most importantly, safe for use for the human body. 

    Other members of the research team included Juliet Gopinath, professor of electrical engineering; Shu-Wei Huang, associate professor of electrical engineering; Victor Bright, professor of mechanical engineering; PhD graduates Jan Bartos and Eduardo Miscles; and PhD student Jonathan Musgrave. 

    “Our work presents an opportunity where we can hopefully detect health conditions earlier and improve the lives of people,” said Gopinath. 

    Where zebrafish meets the eye

    To test the device’s ability to perform biomedical imaging, the researchers turned to a surprising aquatic animal: zebrafish. 

    Zebrafish have been used in OCT research because the structure of their eyes is fairly similar to the structure of the human eye. For the study, the researchers focused on identifying where the cornea, iris and retina was from the zebrafish. 

    To conduct in-vivo or other bioimaging, scientists need to be able to identify the structure of the samples of interest, such as the eye or organs inside the body. The two benchmarks that the group hoped to achieve were 10 micron in axial resolution and then around 5 microns in lateral resolution, all smaller than the width of a human hair.

    “The interesting result was that we were able to actually delineate the cornea and iris in our images,” said Gilinsky. “We were able to meet the resolution targets we aimed for, which was exciting.” 

    Being able to test this bioimaging device can open new doors for mapping aspects of the retina that can be essential for diagnosing potential eye conditions like age-related macular degeneration and glaucoma. 

    Additionally, Gilinsky said, the new bioimaging technique could help in delineating actual human coronary features that would be important in diagnosing heart diseasethe leading cause of death in the United States. 

    With the research team’s expertise in microscopy systems, they are hopeful to create endoscopes that could revolutionize bioimaging technology. 

    “There is a growing push to make endoscopes as small in diameter and flexible as possible to cause as little discomfort as possible,” he said. “By using our components, we can maintain a very small-scale optical system compared to a mechanical scanner that can help OCT technologies.” 

    The project was funded by the Office of Naval Research, National Institutes of Health and the National Science Foundation.

    Source:

    University of Colorado at Boulder

    Journal reference:

    Gilinsky, S., et al. (2025). Nonmechanical spectral domain optical coherence tomography using an electrowetting beam-scanner. Optics Express. doi.org/10.1364/oe.565684.

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  • Dollar struggles as Fed rate-cut bets build; bitcoin soars to record high – Reuters

    1. Dollar struggles as Fed rate-cut bets build; bitcoin soars to record high  Reuters
    2. Global FX Market Summary: Federal Reserve’s Monetary Policy and Independence, US Dollar’s Weakness, US-Russia peace summit 13 August 2025  FinanceFeeds
    3. Forex Today: Attention remains on US inflation, UK GDP and the jobs report in Australia  Mitrade
    4. US Dollar Forecast: USD Dump Extends on Fears of 3 Fed Cuts This Year  FOREX.com
    5. U.S. Dollar softens as markets cling to Fed pivot hopes – United States – English  Convera

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  • Quit Ozempic or Wegovy? Here’s How Fast the Pounds Can Come Back – SciTechDaily

    1. Quit Ozempic or Wegovy? Here’s How Fast the Pounds Can Come Back  SciTechDaily
    2. Help needed to keep weight off after obesity jabs  BBC
    3. NICE recommends better support for weight-loss patients after treatment  Nursing in Practice
    4. ‘I lost 4st on Mounjaro – but piled weight back on when I stopped taking it’  The Independent
    5. People need support to keep weight off after treatment ends  NICE website

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  • Seismic vulnerability assessment of buildings in high-risk areas: A modified rapid visual screening approach in Pakistan

    Seismic vulnerability assessment of buildings in high-risk areas: A modified rapid visual screening approach in Pakistan

    In Dir City, Pakistan, the majority of structures are non-engineered and old, and were built by local masons. Based on the Building Code of Pakistan, the city falls within Seismic Zone III, and these could be vulnerable during a seismic event.

    In a study (DOI:10.1016/j.jdd.2025.100018 ) published in Journal of Dynamic Disasters, a hundred randomly selected buildings, including residential, commercial, government, and religious buildings, were assessed in a (rapid visual screening) RVS survey via a modified Federal Emergency Management Agency (FEMA) data collection form.

    “The structural configuration of the surveyed buildings was diverse—unreinforced masonry, confined masonry, stone masonry, and reinforced concrete (RC) frames with unreinforced masonry (URM) infill,” shares first author Khan Shahzada.

    The authors used positive and negative score modifiers to assign and modify basic scores based on characteristics that increase or decrease seismic resistance in a building; low final scores indicate the need for further expert examination. The final scores were then mapped to damage grades representing potential vulnerability. Drawing on the findings, suggestions for improving the earthquake resilience of Dir City are offered.

    Based on the Building Code of Pakistan, falls within Seismic Zone III.

    “We recommend several actions to mitigate seismic risk and improve the seismic resilience of the buildings in Dir City,” says Khan. “These recommendations focus on enforcing stricter regulations, retrofitting vulnerable structures, and fostering community engagement to build a culture of preparedness.”

    According to the authors, the following steps should be prioritized:

    •Ensure that all new buildings, especially those located on slopes, adhere to engineering design standards to reduce seismic vulnerability.

    •Prioritize retrofitting of older, non-engineered buildings, especially residential structures with a relatively high risk of severe seismic damage.

    •Implement regular inspections to verify compliance with seismic safety standards and to identify necessary repairs.

    •Educate residents on the importance of seismic resilience and encourage them to take steps to improve the seismic safety of their homes.

    •Offer grants or low-interest loans to building owners to encourage investment in retrofitting and structural improvements.

    •Create comprehensive plans that include early warning systems, earthquake drills, and the strengthening of critical infrastructure such as hospitals and schools.

    •Residents should actively seek professional seismic evaluations of their buildings, invest in retrofitting, and ensure that new buildings comply with seismic resistance standards.

    •Residents should acquire emergency kits, create family emergency plans, and facilitate and organize community discussions about seismic risks to build a culture of preparedness.

    •Researchers should expand on Level 1 screenings by conducting highly in-depth studies on retrofitting methods, material performance, and slope stability.

    •Perform studies assessing the impact of retrofitting measures and explore modern technologies such as seismic isolation systems to enhance the seismic resilience of buildings.

    •Involve local stakeholders in applying research findings and improving the seismic safety of Dir City’s infrastructure.

    ##

    References

    DOI

    10.1016/j.jdd.2025.100018

    Original Source URL

    https://doi.org/10.1016/j.jdd.2025.100018

    About Journal of Dynamic Disasters

    The Journal of Dynamic Disasters is one journal dedicated to publishing authoritative articles on dynamic disasters. Topics of interest include earthquake, wind, wave, explosion, shock, vehicle and environmental vibrations. The journal features original research and case studies focusing on the dynamical analysis, disaster mechanisms, disaster prevention, disaster monitoring, disaster assessment and post-disaster restoration for engineering structures (such as civil engineering structures, mechanical engineering structures, aerospace structures, marine structures). The journal welcomes interdisciplinary studies, covering topics such as sensing, signal processing, intelligent management and control of dynamic disasters.


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  • New technique enables efficient loading of large biomolecules into exosomes

    New technique enables efficient loading of large biomolecules into exosomes

    Exosomes, naturally derived vesicles responsible for intercellular communication, are emerging as next-generation drug delivery systems capable of transporting therapeutics to specific cells. However, their tightly packed, cholesterol-rich membranes make it extremely difficult to encapsulate large molecules such as mRNA or proteins. Conventional approaches have relied on techniques like electroporation or chemical treatment, which often damage both the drugs and exosomes, reduce delivery efficiency, and require complex purification steps-all of which pose significant barriers to commercialization.

    A joint research team led by Dr. Hojun Kim at the Center for Advanced Biomolecular Recognition and Dr. Hong Nam Kim at the Center for Brain Convergence Research of the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh) has developed a novel drug-loading technique that allows large biomolecules to be efficiently incorporated into exosomes simply by mixing. This breakthrough enables stable drug encapsulation in under 10 minutes, eliminating the need for specialized equipment or complex processing.

    The team utilized a lipid-based nanoparticle known as a “cubosome,” which mimics the fusion structure of cell membranes and naturally fuses with exosomes. By mixing cubosomes carrying mRNA with exosomes at room temperature for just 10 minutes, the researchers achieved efficient fusion and confirmed that the mRNA was successfully loaded into the exosomes. Analysis showed that over 98% of the mRNA was encapsulated, while the structural integrity and biological function of the exosomes were preserved.

    Furthermore, the engineered exosomes demonstrated the ability to cross the blood-brain barrier, one of the most difficult hurdles in drug delivery. Notably, the team observed a “homing” effect, where exosomes return to the type of cell they originated from, enabling targeted drug delivery to diseased tissues. This technology achieves efficient loading of large biomolecules without altering the exosomes themselves, opening the door to practical applications of exosome-based therapies in precision medicine.

    The technique is highly adaptable to clinical environments, as it requires no specialized equipment or complex processing. It preserves exosome function while enabling the delivery of large payloads, offering broad potential for the treatment of intractable diseases, including neurological disorders, cancer, and autoimmune conditions. The team plans to conduct further safety evaluations for clinical translation and establish a mass production system for cubosomes.

    This technology allows medical professionals to easily combine exosomes and therapeutic molecules at the clinical site, making it a meaningful step toward realizing personalized medicine.”


    Dr. Hojun Kim of KIST

    Dr. Hong Nam Kim added, “Because it enables precise drug delivery even in complex tissues such as the brain, it holds great potential for treating a wide range of diseases.”

    Source:

    National Research Council of Science & Technology

    Journal reference:

    Son, G., et al. (2025). Fusogenic lipid nanoparticles for rapid delivery of large therapeutic molecules to exosomes. Nature Communications. doi.org/10.1038/s41467-025-59489-5.

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  • 11 dengue-related deaths reported in Vietnam’s south

    11 dengue-related deaths reported in Vietnam’s south