Author: admin

  • RATIONALE-306 Subgroup Data Further Support First-line Tislelizumab/Chemo in Locally Advanced ESCC

    RATIONALE-306 Subgroup Data Further Support First-line Tislelizumab/Chemo in Locally Advanced ESCC

    Frontline Tislelizumab Plus Chemo in
    Locally Advanced ESCC | Image Credit: ©
    Ashling Wahner & MJH Life Sciences Using AI

    The frontline combination of tislelizumab-jsgr (Tevimbra) plus chemotherapy demonstrated efficacy improvements over chemotherapy alone in patients with locally advanced esophageal squamous cell carcinoma (ESCC), with similar improvements noted in those with locally advanced disease and a tumor PD-L1 tumor area positivity (TAP) score of at least 5%, according to findings from a subgroup analysis of the phase 3 RATIONALE-306 study (NCT03783442).1

    The data, which were shared during the 2025 ESMO Gastrointestinal Cancers Congress, the median overall survival (OS) with tislelizumab plus chemotherapy (n = 49) was 25.6 months (95% CI, 19.4-36.3) in the subgroup of patients with locally advanced disease vs 12.3 months (95% CI, 9.0-21.7) with chemotherapy (n = 39), translating to a 51% reduction in the risk of death (HR, 0.49; 95% CI, 0.29-0.84; P = .0037). The 12- and 24-month OS rates in the tislelizumab arm were 78.5% and 53.5%; in the placebo arm, these rates were 50.9% and 22.6%. The median investigator-assessed progression-free survival (PFS) with tislelizumab was 9.7 months (95% CI, 6.9-19.6) vs 6.9 months (95% CI, 4.2-9.7) with placebo (HR, 0.56; 95% CI, 0.31-1.01; P = .0262); the respective 12-month PFS rates were 46.2% and 18.2%.

    Those with locally advanced ESCC and a PD-L1 TAP score of 5% or higher who received tislelizumab plus chemotherapy (n = 25) experienced a median OS of 26.4 months (95% CI, 15.3-not evaluable [NE]) vs 11.5 months (95% CI, 8.6-19.8) with chemotherapy alone (n = 20), translating to a 63% reduction in the risk of death (HR, 0.37; 95% CI, 0.16-0.83; P = .0067). The 12-month OS rates in the tislelizumab and placebo arms were 72.0% and 45.2%, respectively; the rates at 24 months were 56.0% and 16.9%, respectively. The median investigator-assessed PFS in the tislelizumab arm was 13.2 months (95% CI, 6.8-30.2) vs 6.7 months (95% CI, 4.2-8.6) in the placebo arm (HR, 0.44; 95% CI, 0.19-1.02; P = .269; the respective 12-month PFS rates were 52.4% and 14.8%.

    “In this subgroup analysis of patients with locally advanced ESCC, first-line tislelizumab plus chemotherapy showed substantial and clinically meaningful improvements in efficacy, consistent with the primary and 3-year long-term follow-up analyses,” Eric Van Cutsem, MD, PhD, of the Division of Digestive Oncology at University Hospitals Gasthuisberg, Leuven, and KU Leuven, in Leuven, Belgium, said in a presentation of the data. “These findings further support the use of tislelizumab plus chemotherapy as a first-line treatment option for patients with locally advanced ESCC.”

    Reviewing RATIONALE-306: Design and Prior Data

    The double-blind, randomized, global, phase 3 study enrolled patients with unresectable locally advanced or metastatic ESCC who had measurable or evaluable disease by RECIST v1.1 criteria and an ECOG performance status no higher than 1. Patients had not previously received systemic therapy for advanced disease. They were randomized 1:1 to receive placebo or 200 mg of tislelizumab every 3 weeks plus chemotherapy in the form of platinum plus fluoropyrimidine or platinum plus paclitaxel. Maintenance treatment continued until intolerable toxicity or progressive disease. They were stratified by geographic region (Asia excluding Japan vs Japan vs rest of the world), previous definitive therapy (yes vs no), and investigator-selected chemotherapy regimen (platinum plus fluoropyrimidine vs platinum plus paclitaxel).

    The primary end point of the study was OS in the intention-to-treat (ITT) population and secondary end points were OS in the subgroup of patients with a PD-L1 TAP score of 10% or higher, PFS, objective response rate (ORR), duration of response (DOR), health-related quality of life, and safety.

    Prior data from the study showed that after a minimum follow-up of 3 years, the median OS in all patients who received tislelizumab plus chemotherapy (n = 326) was 17.2 months (95% CI, 15.8-20.1) vs 10.6 months (95% CI, 9.3-12.0) with placebo plus chemotherapy (n = 323), translating to a 30% reduction in the risk of death (HR, 0.70; 95% CI, 0.59-0.83; P < .0001).2 In the tislelizumab arm, the 12-, 24-, and 36-month OS rates were 65.0%, 37.9%, and 22.1%, respectively; in the placebo arm, the respective rates were 44.7%, 24.8%, and 14.1%. In March 2025, the FDA approved tislelizumab plus platinum-containing chemotherapy for first-line use in adult patients with unresectable or metastatic ESCC with a tumor PD-L1 expression of 1 or higher based on RATIONALE-306 data.3

    Delving Deeper Into the Current Post Hoc Subgroup Analysis

    The subgroup analysis sought to evaluate OS and PFS in patients with locally advanced ESCC, which accounted for 13.6% of the 649 patients, including those with both locally advanced ESCC and a tumor PD-L1 TAP score of 5% or higher, which accounted for 51.1% of 88 patients.1 Those with nonmetastatic disease who were not fit for surgery or definitive chemoradiation were retrospectively selected and included in the analysis.

    The baseline demographic and disease characteristics in the locally advanced ESCC subgroup were consistent with those of the ITT population, Van Cutsem said.

    Additional efficacy data showed that in the locally advanced ESCC subgroup, the investigator-assessed ORR with tislelizumab plus chemotherapy was 61.2%, which comprised a complete response (CR) rate of 12.2% and a partial response (PR) rate of 49.0%. With chemotherapy alone, the investigator-assessed ORR was 38.5%, with a CR rate of 12.8% and a PR rate of 25.6%. The time to response (TTR) with tislelizumab was 1.4 months (range, 1.2-23.3) vs 2.6 months (range, 1.2-4.2) with placebo. The median DOR was 12.6 months (95% CI, 6.9-22.1) and 7.1 months (95% CI, 5.5-16.6) in the respective arms.

    In the locally advanced ESCC subgroup that also had a PD-L1 TAP score of 5% or higher, the respective ORRs were 68.0% and 30.0%. In the tislelizumab arm, the CR and PR rates were 16.0% and 52.0%, respectively; in the placebo arm, these respective rates were 10.0% and 20.0%. The median TTR was 1.5 months (range, 1.2-23.3) with tislelizumab vs 2.0 months (range, 1.2-2.7) with placebo. The median DOR in the respective arms was 22.1 months (95% CI, 6.1-NE) and 5.7 months (95% CI, 1.5-NE).

    Safety Spotlight

    The toxicity profile of tislelizumab combined with chemotherapy in the locally advanced subgroup was consistent with that reported in the ITT population, according to Van Cutsem, who added that no new safety signals were observed.

    In the locally advanced ESCC subgroup, 100% and 97.4% of those in the tislelizumab and placebo arms experienced at least 1 treatment-emergent adverse effect (TEAE); 65.3% and 74.4% of the cases were grade 3 or higher, 44.9% and 51.3% were serious, and 6.1% and 5.1% proved fatal. Moreover, 100% of those in the tislelizumab arm and 92.3% of those in the placebo experienced at least 1 treatment-related adverse effect; 59.2% and 59.0% were grade 3 or higher, 28.6% and 20.5% were serious, and 28.6% and 20.5% led to death. TEAEs resulted in treatment discontinuation for 40.8% of those in the tislelizumab arm vs 35.9% of those in the placebo arm. In the tislelizumab arm, 42.9% of patients received subsequent anticancer therapy and 18.4% received subsequent radiation; in the placebo arm, these respective rates were 51.3% and 30.8%.

    Disclosures: Van Cutsem disclosed having participated in advisory boards for AbbVie, Agenus, ALX, Amgen, Arcus Biosciences, Astellas, AstraZeneca, Bayer, BeOne Medicines, Bexon Clinical, BioNtech, Boehringer Ingelheim, Bristol Myers Squibb, Canfour, Daiichi Sankyo, Debiopharm, Elmedix, Eisai, Galapagos, GSK, Hookipa Pharma, Incyte, Ipsen, Lilly, Merck Sharp & Dohme, Merck KGaA, Mirati, Novartis, Nordic, Pierre Fabre, Pfizer, Roche, Seattle Genetics, Servier, Simcere, Takeda, Taiho Pharmaceutical, and Terumo.

    References

    1. Van Cutsem E, Xu J, Raymond E, et al. Tislelizumab + chemotherapy vs placebo + chemotherapy in patients with locally advanced esophageal squamous cell carcinoma: RATIONALE-306 subgroup analysis. Presented at: 2025 ESMO Gastrointestinal Cancers Congress; July 2-5, 2025; Barcelona, Spain. Abstract 389MO.
    2. Yoon HH, Kato K, Raymond, et al. Global, randomized, phase III study of tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced/metastatic esophageal squamous cell carcinoma (RATIONALE-306 update): minimum 3-year survival follow-up. J Clin Oncol. 2024;42(suppl 16):4032. doi:10.1200/JCO.2024.42.16_suppl.4032
    3. Tevimbra approved in US for first-line treatment of advanced esophageal squamous cell carcinoma in combination with chemotherapy. News release. BeiGene, Ltd. March 4, 2025. Accessed July 5, 2025. https://hkexir.beigene.com/news/tevimbra-approved-in-u-s-for-first-line-treatment-of-advanced-esophageal-squamous-cell-carcinoma-in-combination/8379a7c3-35ce-45af-82d3-164c64ecf37c/

    Continue Reading

  • FLASH: Chebet breaks world 5000m record in Eugene with history’s first sub-14-minute run – worldathletics.org

    1. FLASH: Chebet breaks world 5000m record in Eugene with history’s first sub-14-minute run  worldathletics.org
    2. Kurgat leads Kenyan trio in qualifying for world championships  Daily Nation
    3. Kenyan stars to chase Tokyo tickets in Eugene  standardmedia.co.ke
    4. Olympic Champion Chebet to face world record holder Gudaf Tsegay in Oregon  The Eastleigh Voice
    5. Beatrice Chebet Smashes World Record In 5000M At 2025 Prefontaine Classic  FloTrack

    Continue Reading

  • Gill exit triggers tense ERC3 victory battle

    Gill exit triggers tense ERC3 victory battle

    With six stages over a competitive distance of 98.34 kilometres remaining, Charpentier is 3.2sec ahead of Abramowski, who is also competing in a Ford Fiesta Rally3 on Pirelli tyres.

    However, it could have been a three-way battle for first place had Gill not hit trouble nearing the finish of the morning loop.

    Taylor Gill’s Rome debut did not go as planned

    © At World

    Making his FIA European Rally Championship debut, Australian Gill, part of the FIA Rally Star talent detection initiative, was leading by 20.4sec after he won stages two and three of his first Tarmac start since the Croatia Rally in April 2024. But it all went wrong after the penultimate stage of the morning.

    The FIA Junior WRC Championship leader explained: “Basically the fuel pump just died after the 34-kilometre stage. We were exiting the stage and after a few kilometres the car just stopped and couldn’t restart. There’s no damage or anything, the car is already fixed and we’ll restart tomorrow and try set some good stage times.”

    Gill’s exit left Abramowski leading Charpentier by 0.2sec at the midday service halt in Fiuggi after the Frenchman went off and briefly got stuck in a ditch on SS4.

    Tymek Abramowski is set to pounce on Sunday at Rally di Roma Capitale

    Tymek Abramowski is set to pounce on Sunday at Rally di Roma Capitale

    © At World

    While Abramowski, the ERC3 points leader who turns 19 on Monday, focused on an error-free afternoon, Charpentier moved into first place on SS5 and remained in front despite a moment on SS6.

    “We touched a haybale [SS6] but otherwise it was really tough and really hot,” ex-circuit racer Charpentier said. “We have a lack of pace so we’ll have to figure that out this evening and push tomorrow. We clipped the haybale with the rear right and now the wheel is a bit bent so we had to finish like this.”

    Abramowski, competing on Tarmac for only the second time, said: “I tried to keep the pace and don’t do mistakes like on the first loop when I was too slow or too fast in some cuts.”

    Hubert Kowalczyk is a strong third despite set-up issues masking the Renault Clio Rally3 driver’s ultimate pace in the afternoon. “Doing the rally last year helps me because I know a little bit this Tarmac, this grip, but I have so much work and I don’t have time to prepare enough,” the 21-year-old from Poland explained. “Watching my first onboard was in the aeroplane coming here so I try to make what I can.”

    Hubert Kowalczyk sat in third overnight at Roma Rally di Roma Capitale with a day of action remaining

    Hubert Kowalczyk in action on Saturday at Rally di Roma Capitale

    © At World

    Casey-Jay Coleman is on course for an ERC3 career-best fourth after a solid showing from the Irishman. “There was a lot more gravel on the roads than expected but I managed the longer stage in the afternoon better than the first run by conserving the tyres and the brakes,” he said.

    Adam Grahn is fifth on his Tarmac debut with Błażej Gazda and Sebastian Butyński sixth and seventh respectively. Martin Ravenščak, with sister Dora co-driving, overcame brake issues to complete leg one in eighth place.

    After winning SS1 on the streets of Rome last night, Adrian Rzeźnik was hit by an electronics failure on SS2. Although he and co-driver Kamil Kozdroń, who is making his 130th start, tried to fix the issue, they were forced to retire on SS3.

    Hubert Laskowski stopped with suspension damage after SS4 but is set to restart on Sunday.

    Sunday’s action begins at 08:25 local time with the first run through the 11.58-kilometre Guarcino – Altipiani stage.

    Continue Reading

  • Julian McMahon, actor who appeared in 'Fantastic Four' films and TV show "Charmed," has died – San Francisco Chronicle

    1. Julian McMahon, actor who appeared in ‘Fantastic Four’ films and TV show “Charmed,” has died  San Francisco Chronicle
    2. Julian McMahon Dies: ‘Nip/Tuck’, ‘Fantastic Four’, ‘FBI: Most Wanted’ Star Was 56  Deadline
    3. Julian McMahon: Charmed, Nip/Tuck and Fantastic Four actor dies aged 56  BBC
    4. Nip/Tuck, Fantastic Four actor Julian McMahon dies at 56 – Celebrity – Images  Dawn
    5. Hollywood remembers Julian McMahon: Tributes pour in for ‘charismatic, kind’ star  The Express Tribune

    Continue Reading

  • New World Drops Second Anniversary Eve Update

    New World Drops Second Anniversary Eve Update

    Posted in: Games, Mobile Games, Netmarble | Tagged: Tower Of God: New World


    Tower of God: New World has a new update available as players can get in on some events leading up to its Second Anniversary



    Article Summary

    • The 2nd Anniversary Eve update for Tower of God: New World is now live with special in-game events.
    • Two new characters join the roster: SSR+ [Fairy Sword] Sharon and XSR+ [Regular] Khun Mascheny.
    • Participate in the Nonstop Revolution Draw and a rerun of the Heart-Hunting Vacation story event.
    • Earn generous rewards from limited-time content like Tower Fun Run, Lucky Wheel, and Event Boss Battle.

    Netmarble dropped a new update for Tower of God: New World this week, in which they celebrate 2nd Anniversary Eve. Yes, in true mobile game fashion, we can’t just wait to celebrate a proper anniversary event, we have to throw an event for the event to come, and we’re sure there will be an event celebrating how we celebrated the event after that one.  We have more details below as you’ll get two new characters added to the mix and the usual pairing of events, as this will run for the next few weeks.

    Tower of God: New World Drops Second Anniversary Eve Update
    Credit: Netmarble

    Tower of God: New World – 2nd Anniversary Eve

    Two new Teammates have been introduced as part of the update. SSR+ [Fairy Sword] Sharon (Yellow Element, Warrior, Fisherman) is a High Ranker from the Ari Family and the 1st Division Commander of Zahard’s 4th Army, known for her exceptional Needle combat skills and mastery of Shinsu control. Sharon excels at both protecting her allies and maximizing damage output. XSR+ [Regular] Khun Mascheny (Purple Element, Ranged, Spear Bearer), an IF (imaginary) version of Khun Mascheny, is based on the character during her time climbing the Tower as a Regular.  Tower of God: New World celebrates its 2nd Anniversary Eve with limited-time events, offering players the chance to earn generous rewards:

    • [2nd Anniversary] Nonstop Revolution Draw (July 2 – August 13): Players can earn currency by participating in various in-game events. This can be used for the Nonstop Draw to obtain Revolution resources.
    • [Rerun Story Event] Heart-Hunting Vacation (July 2- July 16): Experience the rerun of the story event ‘Heart-Hunting Vacation’ where players can discover the story of Yihwa Yeon and Endorsi while clearing event missions.

    Additional events and content, including Tower Fun Run, Lucky Wheel, Event Boss Battle, and Memorial Pocket are available through August 13 that provide players the opportunity to obtain various in-game rewards.


    Enjoyed this? Please share on social media!

    Stay up-to-date and support the site by following Bleeding Cool on Google News today!


    Continue Reading

  • Alex Palou Finds Even More Speed To Win Mid-Ohio Pole

    Alex Palou Finds Even More Speed To Win Mid-Ohio Pole

    Amid one of the more surprising lineups for a Firestone Fast Six qualifying session this season, there was little shock over who won the NTT P1 Award on Saturday for The Honda Indy 200 at Mid-Ohio Presented by the All-New 2026 Passport.

    NTT INDYCAR SERIES championship leader Alex Palou claimed his series-leading third pole of the season and ninth career pole with a best lap of 1 minute, 5.0215 seconds in the No. 10 Open AI Chip Ganassi Racing Honda. Palou also leads the series this season with six victories and brings a 93-point advantage over second-place Kyle Kirkwood into the race at 1 p.m. ET Sunday (FOX, FOX Sports app, INDYCAR Radio Network).

    SEE: Qualifying Results

    “Ever since I started with CGR, we’ve had great cars,” Palou said. “But we’ve always struggled with qualifying up front. So, this year it has been phenomenal. The speed we have in the cars at every single racetrack we show up at is amazing.

    “It’s all the work that everybody at Chip Ganassi Racing is doing, all our partners. Super happy. Tomorrow is going to be a great day, for sure.”

    Christian Lundgaard will join Palou in the front row after qualifying second at 1:05.2126 in the No. 7 Arrow McLaren Chevrolet, tying his season best set in March at The Thermal Club.

    Palou’s teammate Kyffin Simpson also was a star of the show, qualifying a career-best third at 1:05.7555 during his first Firestone Fast Six appearance in the No. 8 Journie Rewards Chip Ganassi Racing Honda. Simpson managed to produce that stellar performance despite using a used set of Firestone Firehawk alternate tires, shrewdly saving an extra set of new alternate tires for the 90-lap race Sunday.

    Nolan Siegel, in only his second career appearance in the Firestone Fast Six, also qualified a career-best fourth at 1:05.9262 in the No. 6 Arrow McLaren Chevrolet as CGR and Arrow McLaren locked out the first two rows on the starting grid.

    Colton Herta qualified fifth at 1:06.1218 in the No. 26 Gainbridge Honda of Andretti Global w/Curb-Agajanian, while Road America pole winner Louis Foster earned his third trip into the Firestone Fast Six during his rookie season and qualified sixth at 1:06.2398 in the No. 45 Droplight Honda of Rahal Letterman Lanigan Racing.

    While Simpson’s gamble to use only a set of scuffed alternate tires paid off in the Firestone Fast Six, Palou’s desire to ensure good track position on the 13-turn, 2.258 roller coaster of a road course induced him and his team to opt for a new set of Firestone Firehawk alternates in the last qualifying group.

    “We could have saved the last set of new soft tires here in the Fast Six to try and have an advantage tomorrow, but we were like, ‘Man, we really think that starting up front, top three, is always going to benefit us more. We know there are some cars that are going to save those tires, so they’re going to be a big threat tomorrow. But happy with our car and our starting position.”

    Among the Firestone Fast Six, Palou, Lundgaard and Herta used a new set of Firestone alternates. Simpson, Siegel and Foster stayed on used alternate tires.

    Kirkwood, quickest in Friday practice, was slowed by traffic during the second round of qualifying and will start seventh in the No. 27 Andretti Global Honda featuring a special Honda tribute livery this weekend.

    That was disappointing for Kirkwood, the only race winner besides Palou this season. But starting seventh was nowhere near the same trouble suffered by Team Penske, which continues to endure a winless season despite being the most successful team in INDYCAR SERIES history.

    Josef Newgarden was the team’s top qualifier, 18th in the No. 2 PPG Team Penske Chevrolet. Scott McLaughlin was next, 21st in the No. 3 Odyssey Batteries Team Penske Chevrolet, followed by Will Power in 22nd in the No. 12 Verizon Team Penske Chevrolet.

    A 25-minute warmup session precedes the race at 9:30 a.m. ET Sunday (FS1, FOX Sports app, INDYCAR Radio Network).


    Continue Reading

  • Kishane Thompson takes Prefontaine Classic men’s 100m

    Kishane Thompson takes Prefontaine Classic men’s 100m

    Kishane Thompson showed he remains in great shape as he took the 100m at the Prefontaine Classic on Saturday (5 July).

    Fresh from becoming the sixth fastest man in history at the Jamaican nationals, Paris 2024 silver medallist Thompson powered clear of his rivals after making a fast start.

    The 23-year-old lost his form in the closing metres, but he had plenty in hand as he crossed the line in 9.85 seconds. Zharnel Hughes finished strongly to take second in a season’s best 9.91 ahead of Trayvon Bromell (9.94).

    Brandon Hicklin (9.98) also ducked under 10 seconds for fourth place from Ackeem Blake. South African youngster Bayanda Walaza faded late on into sixth place in the Eugene Diamond League athletics meet,

    More to follow…

    Continue Reading

  • Management Strategies for Seminal Vesicle Cysts in Zinner Syndrome: Insights From Two Cases

    Management Strategies for Seminal Vesicle Cysts in Zinner Syndrome: Insights From Two Cases


    Continue Reading

  • Oasis Reunion Concert in Wales Review

    Oasis Reunion Concert in Wales Review

    Photo: Gareth Cattermole/Getty Images

    “This is the biggest weekend of our lives,” Robbie Miller, an affable 32-year-old Scotsman, tells me in between gulps of lager. His friend Jordan Colligan concurs: “I don’t think people realize how big this actually is.” On this blustery, sun-dappled afternoon, the two friends are seated outside the Blue Bell pub in Cardiff, Wales, where they’ve been pregaming since 10 a.m. Eventually they’ll stroll down to Principality Stadium, joining the tens of thousands of other heads to see Oasis perform live. That Oasis.

    The July 4th gig marks the first time Oasis has performed together since 2009, when the two brothers comprising the band’s core — lead vocalist/sometime tambourine player Liam Gallagher and songwriter/guitarist Noel Gallagher — had a backstage meltdown that involved Liam throwing a plum, then attempting to bonk Noel with a guitar, apparently “wielding it like an axe.” While that scuffle wasn’t entirely uncommon for the perpetually clashing Gallaghers, the incident ended with Oasis breaking up indefinitely. But after countless speculated reunions over the years, the brothers finally buried the guitar-shaped axe. Now they were set to play together for the first time in 16 years, with the initial stop happening here in Cardiff.

    At any other concert, it’d be a little too on the nose for the audience to wear a T-shirt of the band to their show. But for Oasis’ first show back from the brink, donning band gear is less a prerequisite than a status symbol. The day of the gig, the seaside city is gripped by full-on Oasis-mania: Fans mill around in full Oasis-branded tracksuits. The energy is electric. “I’m so overstimulated,” a girl walking past me says. In the shadow of Cardiff Castle adjacent to the City Centre, bootleg merch sellers hawk John Lennon glasses and an extensive selection of £15 bucket hats spelling out Oasis song titles on them — “Some Might Say,” “Slide Away” — both sartorial Liam staples from the band’s ’90s heyday. Other hats feature cracks the brothers have made onstage and in colorful interviews, like “biblical” and “mad for it,” which have become lingua franca for their fanbase pining for the reunion. I almost go for one bucket hat that reads “Maybe” (pronounced “maybehhh,” i.e. the way Liam enunciates it in “Wonderwall”). Then I remember I’ve never worn a bucket hat in my life.

    Miller and Colligan are both decked out in head-to-toe Oasis gear: T-shirts, bucket hats, and friendship bracelets spelling out the band’s name. The two had made fast friends of a couple they’d just met at the pub, who’d traveled from Italy for the show and were now doling out beaded bracelets that their 9-year-old daughter had made. The pair are Oasis diehards: “I promised him one day, we will see them together,” Claudia Zarucchi says, beaming at her husband. They offer me a friendship bracelet, with a caveat: Their kid wants a little cash for her labor. Respecting the hustle, I fork over two bucks for this small business. The pair also have a twelve-year old son. His name is Noel.

    Photo: Josh Halling

    Hailing from just outside Manchester, England, Oasis became a cultural phenomenon in the early 1990s by zigging when other musicians were zagging. Their predilection for stadium-ready riffs felt out of step with the acid-drenched dance music dominating their neck of Northern England at the time; their flagrant cribbing of Beatles-inflected psychedelia happened right when grunge had a firm hold on U.S. radio. Oasis’ debut album Definitely Maybe shot straight to No. 1 in the UK upon its release, and their follow-up (What’s the Story) Morning Glory? went nuclear with hits like “Wonderwall” and “Champagne Supernova.” That one-two punch cemented them as boisterous capital-R rock giants and their songs became a ubiquitous presence at karaoke bars around the world.

    But power chords alone did not cause Oasis to transcend into a once-in-a-generation act, the brothers’ tense dynamic did. Liam sang most of the songs in his reedy yowl, all charisma with his hands pulled behind his back, head tilted up towards the sky and a parka often inexplicably zipped all the way up to his chin. The band’s resident wordsmith, Noel, looked like he’d just stepped out of a ’60s time machine with long sideburns and a mop top. Onstage he nimbly wailed on the guitar, lending his voice on harmonies and occasionally singing heartrending numbers of his own. The Gallaghers needed each other, in other words, to pull the whole thing off — if only they could get past the rivalry that began when they were forced to share a room as kids. Their beef frequently manifested in public, with insults that ranged from cutting to hysterical in the press, sometimes tipping into more violent incidents, including one involving a cricket bat. After their breakup, Liam and Noel both went on to release solo projects but continued to talk shit about one another, particularly online. Liam has been known to refer to his elder sibling as “Potato” on X and Noel once groused in an interview that Liam was “a man with a fork in a world of soup.” Fueled by the pent-up lore, Oasis in absentia has arguably become bigger than they were even in the ‘90s. The Umbro jumpers Liam used to wear have become coveted on Depop and the Gallaghers’ shaggy haircuts might be outpacing mullets as the do du jour in some major cities.

    Still, longtime fans had resigned themselves to watching grainy clips on YouTube, concluding that the resentment between the Gallaghers ran too deep to ever prompt a reunion. So when Oasis unexpectedly announced a reunion last year, frenzy ensued. Tickets sold out in minutes for all legs of the tour, which would kick off in the UK and make its way to North and South America, Asia, and Australia in fall 2025. To give a sense of how coveted these tickets are, one estimate holds that 14 million people tried to nab spots for the UK shows — as many people who signed up for Taylor Swift’s Eras tour pre-sale tickets. I stayed up until 3 a.m. the day tickets went on sale, struggling through various queues on several different laptops until I somehow snapped up four tickets for the first show in Cardiff. Miller and Colligan snagged theirs through a friend in Australia, who is running around here somewhere. Some people even pulled the trigger on multiple Oasis dates, including Colin Carhart from Asbury Park, New Jersey. He’s seeing Oasis tonight and tomorrow, also in Cardiff. “There’s no way I was going to miss this,” he says. I meet more than a few American fans and a handful of Canadians, and hear people in Oasis tees speaking in Japanese, Spanish, Mandarin, Welsh, and Portuguese. Sam Lau, a fan who’d come in from Hong Kong the night before, beelined from the train station to buy Oasis merch. The day before, I’d spotted a gaggle of French fans busting out their camping gear, sleeping outside the stadium so they could get a good spot in standing room.

    Photo: Gareth Cattermole/Getty Images

    As it gets closer to doors at 5 p.m. the pubs surrounding the venue are so rammed with fans that they spill out into the narrow street. Some turn people away from the sheer volume. A busker outside the Tiny Rebel bar strums “Don’t Look Back in Anger” to scores of onlookers, drumming up even more hype before people stream inside. We head into the stadium an hour later, surprised by how quick it is to get through security. Heading up the stairs, a kid who can’t be older than eight is with his dad. I ask them who’s the bigger Oasis fan. His hand instantly shoots up: “Me!” We don’t have the greatest view, off to the side to the right of the stage, but good sightlines are beside the point here. Everyone around us hums with nervous anticipation.

    Things start going a little off the rails around the time the show’s second opener, Richard Ashcroft, of The Verve, waves the crowd goodbye after ending his set around 7:45 pm. My fiancé spots a man who can barely stand but is still attempting to carry eight pints of beer up to his seat. The family behind me yells at a group of teens trying to smoke a cigarette inside. A fight almost breaks out four rows down after a man flicks someone else off, but the lads make peace before the main event.

    At 8:13 pm, the Beatles’ “Tomorrow Never Knows” starts blaring a hair louder than the other pre-show songs. From our nosebleeds we can see behind the stage, and catch a glimpse of Noel striding up the side. Liam isn’t far behind him, doing his distinctively silly cock-walk up to the stage. When they make their way in front of the crowd right at 8:15, as promised, everyone bellows at a volume I hadn’t ever heard before at a stadium show. This is suddenly real.

    Perhaps in a bid to keep the band together through the end of the tour, Liam and Noel banter very little onstage, preferring to swiftly run through the songs. (Though at one point Liam thanked the crowd thusly: “Nice one for putting up with us over the years.”) The band plays a smattering of de rigueur Oasis cuts for this first show, a la “Rock ’n’ Roll Star” and “Supersonic,” mostly from their first two albums. The setlist is interspersed with some b-sides and unexpected choices like “Fade Away” and the rabble rousing “D’You Know What I Mean” from their cocaine-fueled third album, Be Here Now. The crowd screams along to every word. Bro hugs between strangers abound. It’s balmy inside the stadium but a guy a few rows over from us keeps his parka pulled up tight, naturally. I’m a little jealous of the people who managed to get standing room tickets, though seeing everyone bounce in unison to the barnburner “Slide Away” from above is a wild sight.

    Photo: Paula Mejía

    The band sounds locked in, especially after the first few numbers, the songs crisp and sonorous in the cavernous space. Liam’s nasal-tinged vocals resound damn near the same as they did on records from thirty years ago, and Noel’s shredding feels somehow even more massive. Almost no one sits down over the course of two-plus hours. After a brief encore, the guys come back out for several of their biggest numbers, “Don’t Look Back in Anger,” “Wonderwall,” and “Champagne Supernova,” which elicit the biggest singalongs of the night. The Gallaghers end it by gamely fist bumping and briefly hugging it out before walking off. In a perfectly rock star move, Liam gets into a Range Rover that had pulled into the stadium near the side of the stage, doors open, that swiftly whisks him away into the night. Noel prefers to walk out alone, waving to the roaring crowd leaving.

    After the show lets out, the fanfare is somehow even more pronounced. A few fans we chat with by the bathrooms, who’d seen Oasis back in the ‘90s, are already plotting on how to get tickets to future shows on this tour. While no one knew quite what to expect from this reunion, I’d venture to say that most people were happy to be here regardless of the show’s quality. That Oasis actually delivered only made people even more feral; the consensus among everyone we run into is that they’ve never sounded better. My brother and his wife, who’d also traveled from Brooklyn for the show, are so moved by the experience that they end up posting their pregnancy reveal on Instagram after snapping a photo of themselves from our seats: “Baby’s first concert.”

    Photo: Gareth Cattermole/Getty Images

    No one wants to leave. Fans mob the surrounding streets, trudging back into pubs and bustling clubs on the high street. An industrious man has set up a mobile karaoke stand in the middle of one road, where a fan is already belting “Stand by Me.” We stop for late-night gyros and meet two longtime friends, Mark Brown and David O’Brien. This is the first of seven Oasis shows Brown is seeing — he’s going to two gigs in Manchester, another two in London, one in Dublin, and one in New York. When I ask him how much he spent on tickets alone, he smiles bashfully. “I haven’t properly calculated it, but it’s a lot,” he admits. Brown had seen Oasis back in the day but says this was easily the best they’d sounded, which he attributes to “the build up, not knowing what to expect, and hearing how fucking good they were.”

    This show means a lot to both Brown and O’Brien. They brought a Union Jack to the show with them, to which they’d pinned the Oasis logo and a small purple ribbon commemorating their friend Liam Howell, who died last year at the age of 36. They had all gone to see Oasis together in Manchester in 2009, but Howell didn’t make it to the show — he got so excited that he drank a little too much and missed it altogether. “There was some part of him here with us” tonight, O’Brien says. “It’d have been amazing having here. He’d have been here, he’d have gone home before the gig,” Brown laughs. Brown managed to snag a few extra tickets to one of the Oasis shows at Wembley Stadium in a few weeks, and he’s bringing Howell’s siblings with him.

    Both O’Brien and Brown both grew up in Bradford, near the Gallaghers’ hometown around Manchester. To them, Oasis are “central to how we are,” O’Brien says. The Gallaghers were “working class lads” who “had fuck-all growing up,” Brown says. “I think that’s why we’re drawn to them. “Very relatable,” O’Brien nods. “I’ve waited 20 years for this gig.”

    Continue Reading

  • A titanic battle at the front, Ollie Bearman’s redemption and changeable weather – What To Watch For in the British Grand Prix

    A titanic battle at the front, Ollie Bearman’s redemption and changeable weather – What To Watch For in the British Grand Prix

    From a six-way fight for the win, to a track that often provides thrilling wheel-to-wheel battles, plus Oliver Bearman on the charge to the potential for rain to impact the start of the race, here are a few things to look out for during Sunday’s British Grand Prix at Silverstone…

    1. Verstappen’s fight with the McLarens

    Qualifying was a thriller on Saturday afternoon, and it came down to the very final lap as Max Verstappen finished on top in what proved to be a battle between six different drivers.

    Both McLarens were very much in the frame, but Verstappen was able to pip Oscar Piastri and secure his first pole position since Miami with an extremely impressive final attempt. Piastri starts from second and Lando Norris from third – just 0.118s adrift of Verstappen’s time himself.

    Continue Reading