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  • Anxiety, depression and sleep medicines linked to higher risk of neurological disease

    Anxiety, depression and sleep medicines linked to higher risk of neurological disease

    Commonly prescribed medicines for anxiety, depression and sleep disorders may pose a heightened risk of developing amyotrophic lateral sclerosis (ALS), a progressive and fatal neurological disorder, according to a new study recently published in JAMA Neurology.

    The study researched the use of anxiolytics (used to relieve anxiety), hypnotics and sedatives (used to aid sleep or calm the body), and antidepressants (which work by altering brain chemistry to improve mood) and found that individuals who were prescribed such medications were more likely to be diagnosed with ALS in the later stages of life.

    The study further found that people who used these medication before being diagnosed with ALS had a poorer prognosis, which means that their disease progressed quickly and survival rate is minimal. However, experts caution that this finding is based on association, not causation.
    “These medications are often prescribed for symptoms such as anxiety, sleep disturbances, or depression, which may appear during the early (prodromal) phase of ALS – well before a formal diagnosis,” explained Dr M S Panduranga, senior consultant (neurology), Dharamshila Narayana Super-specialty Hospital.

    “So, the link may reflect early, subtle neurological changes rather than the harmful effect of the drugs themselves,” the doctor added.


    The study, which was conducted in Sweden, analysed nationwide data from over 1,000 ALS patients and more than 5,000 healthy individuals using the Swedish Motor Neuron Disease Quality Registry. The average age of participants was 67.5 years, and just over half (53.1%) were male.Dr Manjari Tripathi, professor and head of neurology at AIIMS, told TOI that such neuropsychiatric medications act on the brain’s inhibitory pathways, which could interfere with motor neuron activity. “There could also be a toxic effect, especially with long-term, consistent use – not just occasional doses,” she said.

    “Motor neuron disease leads to slow but steady progression of muscle weakness. Patients begin to struggle with everyday tasks – buttoning a shirt, combing their hair, walking. Eventually, they become wheelchair bound. Swallowing and speech become difficult, and muscles visibly shrink,” she said, adding that one type of ALS was the same condition renowned physicist Stephen Hawking lived with for decades.

    However, the exact timeline between the medication and the onset of ALS remains unfound. Dr Madhukar Bhardwaj, director and head of neurology, Aakash Healthcare, said that a longer history of psychiatric symptoms and prolonged medication use appears to be associated with increased ALS risk.

    “In some observational studies, individuals using anxiety or depression medications for more than 10 years showed a stronger link with ALS, especially in younger patients. It’s not yet certain whether this reflects a true biological risk or simply earlier diagnosis due to more medical attention,” he said.

    “While there’s no definitive proof that these medications cause ALS, we need to be cautious, especially when prescribing them to individuals with signs of neurological disease,” Dr Anshu Rohatgi, vice-chairperson (neurology), Sir Ganga Ram Hospital told TOI.

    Meanwhile, doctors say patients must not stop medications on their own and should speak with their healthcare providers if they have concerns.

    (With TOI inputs)

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  • Belinda Bencic, last mum remaining, breaks through at Wimbledon

    Belinda Bencic, last mum remaining, breaks through at Wimbledon

    In a Championships beset by upsets, the eventual quarterfinal line-up on the women’s side is stacked with quality.

    Multiple Grand Slam champions Aryna Sabalenka and Iga Swiatek are there, as is fellow top-eight seed Mirra Andreeva.

    RELATED: Why the women’s Wimbledon champion is so hard to predict

    Pundits’ semifinal prediction Amanda Anisimova has also made it to the last eight and so too Liudmila Samsonova, a two-time WTA tournament champion on grass. There’s also 2021 Roland Garros finalist Anastasia Pavlyuchenkova, and Bencic, a former world No.4.

    Bencic returned to professional tennis as an unranked mother last October following 13 months away, yet has already trimmed her ranking to 35th.

    A Wimbledon junior champion in 2013 who felt an immediate affinity for grass when she first set foot on it, she looms as one of the more formidable players remaining.

    She owns 50 tour-level match wins on grass – the most of any women’s quarterfinalist this year – and a winning rate on the surface approaching 70 per cent.

    The former Eastbourne champion enters her quarterfinal match-up against Andreeva with the confidence of having won six of her seven career grasscourt quarterfinals.  

    She was also one point away from an eight grasscourt quarterfinal at Wimbledon in 2023, before Swiatek staged a dramatic Centre Court comeback to deny her.

    “I’m happy I finally got through today from the fourth round; I always got stuck in the fourth round,” she laughed in a Tennis Channel interview. “I’m really happy with how I played better from round to round and I’m improving on the court, so I hope to continue like that.”

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  • Elon Musk’s ‘America Party’ may threaten President Trump, warn analysts

    Elon Musk’s ‘America Party’ may threaten President Trump, warn analysts

    US President Donald Trump and Elon Musk attend a press conference in the Oval Office of the White House in Washington, DC, US, May 30, 2025. — Reuters

    WASHINGTON: Although US President Donald Trump has brushed off Elon Musk’s plans for a new political party as “ridiculous”, the tech billionaire’s announcement underscored the threat the disaffected former ally poses to US Republicans defending paper-thin congressional majorities.

    Musk’s weekend launch of the “America Party” came in the wake of Trump signing into law a sprawling domestic policy bill that the tech mogul has slammed over estimates that it will balloon the deficit.

    The Tesla founder has been light on policy detail, but is expected to target a handful of House and Senate seats in next year’s midterm elections where the sitting Republican voted for Trump’s bill after preaching fiscal responsibility.

    “[Elon] Musk’s America Party is a wild card that could upend the midterms in 2026, particularly for Republicans,” said political analyst Matt Shoemaker, a former Republican congressional candidate and an ex-intelligence officer.

    “With bare majorities in Congress, the Republicans should be worried.”

    Musk, the world’s richest person, had teased the idea of a new party for weeks, running an informal social media poll in June that showed 80% support among 5.6 million respondents.

    Unlike previous third parties, his would have almost limitless resources, and a talisman with a large constituency of young American men who see him as a maverick genius and a superstar.

    “Musk’s brand appeals to disaffected independents and younger, tech-savvy voters who might otherwise break for Republicans in swing districts,” Shoemaker told AFP.

    Lower favourability than Trump

    With a personal wealth estimated at $405 billion, Musk has already demonstrated that he is willing to spend big on politics, lavishing $277 million on Trump’s 2024 campaign.

    Yet a more recent foray into Wisconsin politics — he spent $20 million only to see his candidate for the state supreme court lose handily — has underlined the limits of wealth and celebrity in politics.

    And then there is the political difficulty of building support in the American heartland, among voters who are not part of Musk’s Silicon Valley “tech bro” bubble.

    Time magazine۔s 2021 Person of the Year was once liked by a broad cross-section of Americans, but he saw his numbers plunge after joining the Trump administration as the president۔s costcutter-in-chief.

    Musk’s net favorability in the most recent rating published by Nate Silver, one of the most respected US pollsters, is underwater at -18.1, compared with a slightly less subaquatic -6.6 for Trump.

    “While you don’t want to paint with too broad a brush, the Republican base and MAGA movement are fairly inseparable in today’s political climate,” said Flavio Hickel, associate professor of political science at Washington College in Maryland.

    “And their support for Trump has been unwavering despite recent controversies. It۔s hard to imagine any political project associated with Musk siphoning off votes from individuals who approve of [Donald] Trump,” he added.

    History, record of third parties

    While multiple Republicans and Democrats have switched to independent, wins for third parties have been rare in modern US history.

    The Conservative Party of New York State in the 1970s and the Farmer-Labour Party in the 1930s are the only minor parties to win Senate seats in the last century.

    Smaller parties saw more success in the House in the early 20th century but have only won one seat since the 1950s.

    AFP spoke to multiple analysts who pointed to the many hurdles thrown in front of third-party candidates trying to get onto the ballot in a system designed to favour the status quo.

    These include minimum signature requirements, filing fees and other onerous state-specific regulations on age, residency and citizenship.

    “Remember in early 2024 the so-called ‘No Labels’ party that was going to chart a middle course for the 2024 elections?” said veteran political strategist Matt Klink.

    “They fizzled out in epic fashion.”

    Analysts agree that winning seats in Congress may be a stretch, but say Musk can inflict pain on Trump by syphoning votes from vulnerable sitting Republicans or throwing cash at primary opponents of the president´s preferred candidates.

    “Musk’s party won’t win seats, but it could cost Republicans plenty,” said Evan Nierman, the founder and CEO of global crisis PR firm Red Banyan.

    “In tight districts, even a few points siphoned off from the right could flip control,” he added.


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  • ‘They feel cleansed, they cry … some really don’t like it!’ The 12-hour psychedelic theatre-rave Trance | Dance

    ‘They feel cleansed, they cry … some really don’t like it!’ The 12-hour psychedelic theatre-rave Trance | Dance

    Naked performers covered in paint roll around atop dirt and foliage. Menacing sculptures hang from the ceiling and walls. The costumes have a beastly quality. At one point, a stream of feathers are strewn across the stage; at another, pink petals float down from above. This is Trance, an immersive psychedelic experience inspired by an eclectic mix of influences from electronic music and rave culture to Buddhism, cartoons and Japanese Butoh dance theatre.

    When 39-year-old Chinese artist and director Tianzhuo Chen first had the idea for Trance in 2019, it was to accompany a solo exhibition of his work at M Woods Museum in Beijing. The initial result was a three-day performance with each fraction spanning 12 continuous hours. It has since been whittled down to a single 12-hour-long production. This month, the show is on in London as part of the Southbank Centre’s ESEA Encounters, a series celebrating east and south-east Asian arts and culture.

    It will serve as somewhat of an artistic homecoming for Chen, who did his undergraduate and master’s degrees at Central Saint Martins and Chelsea College of Arts, respectively. “London definitely influenced a lot of the club part of it,” he says over video call, dressed in a simple black T-shirt and clear-frame glasses. “When I was living in the UK, I was pretty young and I experienced a lot of its club culture.” Since graduating in 2010 (and returning to China for some years after), he has made a name for himself by bringing the sacred and the subcultural together.

    Watch a taster for Trance

    In 2015, Chen founded the music-art-dance collective Asian Dope Boys, which earned a cult following for shows resembling both religious ceremonies and avant garde techno parties. In 2018, 20 members toured Europe performing at venues including London’s Barbican, the Palais de Tokyo in Paris and Säule, an experimental space at Berlin’s iconic club Berghain.

    He has lived in Berlin for the last three years. In 2024, at the city’s HAU performance space, Chen premiered Ocean Cage, a video and performance piece inspired by stories from Lamalera. The fishing village in Indonesia is one of the last communities in the world where traditional whale-hunting still exists – the locals relying on it for both sustenance and as part of their spiritual beliefs. “Because it’s a volcano island, it doesn’t grow anything, so they have to go whaling for their survival,” he says, explaining that they believe that their ancestors were reborn as whales in order to feed the village.

    With Trance, Chen wanted to bring people from different disciplines together. “Musicians, performers, professionals, non-professionals, all of it,” he explains. Six years on, the genre-bending theatre-rave has been performed around the world. The latest version can be divided into six two-hour chapters, each reflecting on Buddhist themes, especially the idea of reincarnation, which in its cosmology has six realms: gods, demigods, humans, animals, hungry ghosts and hell. “In the beginning, they are performing from an image of hell,” he says of a sequence also referencing a series of 15th-century Japanese paintings that explore the different stages of death. “A beautiful woman dies, her rotting corpse is eaten by dogs and becomes dust at the end,” he says. For him, the first chapter feels particularly meditative. “It comes from the Buddhist idea of how you treat your body, and that there is nothing left other than flesh when you die.”

    Sharing the moment … Trance. Photograph: Pierre Zylstra

    By the final chapter, Trance shifts into what Chen calls a “collective rave” and takes a more optimistic turn. “The last part is the most human; everyone is dancing on their own,” he says. “It’s the part most strongly related to club culture, to dancing, to the expression of the individual.” It’s also the point in the performance when those watching get most involved. “So much of it is sharing the moment with the audience,” making them a part of “this ritual and ceremony, a healing and cleansing-type moment”.

    Trance does not follow an explicit narrative, allowing it to evolve as it moves through continents and venues. “It’s a little bit site-specific, as the stage never looks the same,” he says. He points out that some venues are well-equipped, some offer outdoor space, and some are simply dilapidated buildings. But, as a result, he never gets tired of showing it. “Little changes and different conditions keep this work progressing because it has to,” he says. At the Southbank Centre, “we are creating a special design for it, and we are using their big theatre room to screen Ocean Cave”.

    Ritual and ceremony … Trance. Photograph: Pierre Zylstra

    He has also invited the Japanese dubstep musician Takeaki Maruyama, known professionally as Goth-Trad, to perform. “I went to a lot of dubstep parties when I was in London before some of the legendary dubstep clubs closed down, so now feels like the time to embrace it,” says Chen.

    It’s not every theatre production that can also double as a 12-hour rave. “I get a lot of feedback,” says Chen. “People say it’s the best performance ever … they feel healed, they feel cleansed, they cried, all these feelings. And then some people really don’t like it! All this strong emotion is what I appreciate. You don’t have to understand the story or have any background knowledge – how you emotionally relate and connect with the piece is the most important thing to me.”

    Tianzhuo Chen: Trance is at Queen Elizabeth Hall Foyer, London, on 18 July as part of the Southbank Centre’s ESEA Encounters season, which runs 17-20 July

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  • China Inc bets Beijing will keep tight grip on yuan as US tariff fears persist – Reuters

    1. China Inc bets Beijing will keep tight grip on yuan as US tariff fears persist  Reuters
    2. Yuan softens as markets await US tariff deadline  Business Recorder
    3. Analysis-China Inc bets Beijing will keep tight grip on yuan as US tariff fears persist By Reuters  Investing.com
    4. Why China’s yuan is forecast to keep strengthening against the US dollar  South China Morning Post
    5. PBOC sets USD/ CNY central rate at 7.1534 (vs. estimate at 7.1772)  TradingView

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  • US trade pause a factor in 15% JLR sales fall

    US trade pause a factor in 15% JLR sales fall

    Jaguar Land Rover has said its sales have dropped by 15.1% over the three months to June, partly because of the threat of US tariffs.

    The Coventry-based car manufacturer, which also has sites in Solihull and at i54 near Wolverhampton, paused shipments to the US in April after President Trump’s administration introduced new tariff plans.

    It said the drop in sales was also partly due to the planned wind-down of older Jaguar models.

    In April, the US government said it would launch an additional 25% tariff on car imports, but it later came to a deal with the UK and JLR restarted exports in May.

    JLR said its retail sales were down by 94,420 units over the three months to June and wholesale sales dropped by 10.7% to 87,286 units compared with a year earlier.

    The US said its tariff on car imports was intended to encourage more car production within the country.

    The deal it reached with the UK was to introduce a lower 10% tariff for the first 100,000 UK-manufactured cars imported into the US each year.

    UK cars imported to the US beyond this threshold will, however, face a 27.5% tariff.

    The car firm said on Monday that wholesale sales in North America dropped by 12.2% year-on-year when it paused shipments.

    However, wholesale sales in the UK saw a bigger fall, by a quarter, because of the “planned cessation of the legacy Jaguar models”.

    Jaguar stopped selling new cars in the UK late last year to allow it to shift production to new electric models, which are set to go on sale in 2026.

    At the time the import tariffs were first announced, Prof David Bailey of Birmingham Business School said one in four JLR cars were sent to the United States.

    He said it was the premium and luxury cars which sold especially well there and the US was the second biggest market for the UK’s industry after the European Union.

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  • Global Debut! iSoftStone Digital Officially Launches as iSoftStone’s New Overseas Brand

    Global Debut! iSoftStone Digital Officially Launches as iSoftStone’s New Overseas Brand

    BEIJING, July 8, 2025 /PRNewswire/ — On July 3, 2025 Global Digital Economy Conference was grandly held in Beijing. As part of the conference’s signature “First Launch Global Debut” segment, iSoftStone officially introduced its new overseas brand, iSoftStone Digital, to the international market. This milestone marks the company’s entry into “Going Global Expansion2.0” strategy. With a renewed positioning of driving global client value through digital technology innovation, iSoftStone Digital is opening a new chapter in its international development journey.

    At the launch ceremony, Mr. Liu Huifu, Director and Chief Technology Officer; Mr. Han Zhimin, President of Computing Products and Smart Electronics Business; Mr. Huang Li, President of International Business; Mr. Yin Lu, Vice President; and Mr. Li Chuan, Vice President jointly witnessed the new era of “iSoftStone Digital”, marking a significant milestone in the company’s global expansion strategy.

    As a Chinese leading enterprise in full-stack intelligent products and services, iSoftStone has always committed to global expansion, identifying “international growth” as one of its four core strategies. Over the past twenty years, the company has steadily built a global business network spanning four key regions: Southeast Asia, the Middle East, Japan, and North America. The release of this new brand is another important milestone in iSoftStone’s overseas development. With a fresh brand identity, the company aims to further empower Chinese enterprises going abroad and support global clients in their digital transformation efforts.

    During the launch ceremony, Mr. Yin Lu delivered a comprehensive interpretation of the brand’s strategic positioning and significance. He stated, “iSoftStone Digital not only carries two decades of iSoftStone’s innovation and global vision, but also represents our firm commitment to empowering global clients with digital technology and building a better future together.” Moving forward, iSoftStone will empower global clients with seven strategic digital solutions and innovative products from its proprietary hardware brand MECHREVO.

    Later, five key leaders took the stage together, placed their handprints on the brand activation panel, marking the official launch of iSoftStone Digital.

    iSoftStone Digital aims to enhance its global presence by integrating resources and accelerating innovation. The company will focus on creating a strong outbound ecosystem, supporting enterprises in their international growth, and becoming a benchmark for Chinese tech firms worldwide. With an emphasis on collaboration, iSoftStone Digital is committed to advancing the global digital economy.

    SOURCE iSoftStone

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  • Cierra Ortega exits ‘Love Island USA’ villa following backlash over resurfaced racial slur posts – Firstpost

    Cierra Ortega exits ‘Love Island USA’ villa following backlash over resurfaced racial slur posts – Firstpost

    Her departure, announced Sunday, followed weeks of uproar from viewers after old posts from Ortega resurfaced that contained a racial slur against Asian people

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    Cierra Ortega, a contestant of this summer’s “Love Island USA” left the villa just a week before the finale of the hit reality series is set to air on Peacock.

    Her departure, announced Sunday, followed weeks of uproar from viewers after old posts from Ortega resurfaced that contained a racial slur against Asian people. The show’s narrator, Iain Stirling, announced Ortega had departed “due to a personal situation” early in Sunday’s episode.

    Ortega becomes the second contestant this season to depart the show amid controversy due to past social media posts. Yulissa Escobar abruptly exited last month in the second episode after clips of her using racist language resurfaced online. Her departure was also not explained in the show.

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    A spokesperson for the show declined to comment Monday.

    Ortega’s family posted to her Instagram story Sunday evening following the announcement of her departure, asking the public “for compassion. For patience. For basic human decency.

    “While Cierra is not in the villa anymore, she is still away. She hasn’t had the chance to process any of this or speak for herself,” her family wrote. “But we know our daughter. We know her heart. And when she returns, we believe she’ll face this with honesty, growth, and grace.”

    Her family said they, along with Ortega’s friends and online supporters, have received threats, attacks and cruel messages on social media, noting that “no one deserve that kind of hate, no matter what mistakes they’ve made.”

    “Love Island USA” is an American spin-off of the original U.K. series and is airing its seventh season. The show airs daily except Wednesdays and brings young singles together in a remote villa in Fiji to explore connections with the ultimate goal of finding love.

    Couples undergo challenges and are encouraged test their romantic connections as new contestants are introduced. Islanders are routinely “dumped” from the villa throughout the series as stronger couples form. The winning couple receives $100,000.

    The show, which strips contestants of their phones or access to the outside world, has previously asked fans to avoid cyberbullying contestants. Host Ariana Madix called for fans to stop doxxing and harassing the show’s stars in a recent interview with The Associated Press.

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    Ortega entered the villa at the end of the first episode as a bombshell, one of the first in a steady stream of new contestants who come in after the show began, often expected to disrupt existing couples and create new relationship dynamics.

    Ortega quickly coupled up with Nic Vansteenberghe, whom she remained with up until her departure. Her exit broke up one of the few consistent couples of the season. The couple had just announced a few episodes prior they were “closed off,” a popular “Love Island” phrase to indicate neither contestant was interested in exploring a connection with any other islander.

    “Before Cierra had left, my mind was clear. I knew what the future would look like, and now, I’m lost,” Vansteenberghe said during Sunday’s episode.

    Vansteenberghe stayed on the show as a single islander after Ortega left, and he ultimately re-coupled with fellow contestant Olandria Carthen before the end of the episode.

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    Belle-A Walker, a contestant who was dumped earlier this season, took to Instagram to express heartbreak over Ortega’s resurfaced posts. Walker, who is Asian American, said she is “deeply appreciative” of the show’s producers “for taking a stand and making it clear that racism of any kind is not tolerated.”

    “Asian hate is oftentimes overlooked and dismissed. But being a first-generation American, I have personally witnessed and experienced how real and hurtful comments like these are,” Walker wrote on her Instagram story page. “It is my hope that this situation can help shed light on how big of an issue anti-Asian hate really is.”

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  • Scientists uncover hidden superfamily of lipid trapping proteins in bacteria

    Scientists uncover hidden superfamily of lipid trapping proteins in bacteria

    Scientists have identified a new type of protein in bacteria that could change our understanding of how these organisms interact with their environments.

    A new study, published in Nature Communications, focuses on a protein called PopA, found in the bacterial predator Bdellovibrio bacteriovorus. The protein forms a unique fivefold structure, unlike the usual single or three-part structures seen in similar proteins.

    Supported by the Wellcome Trust, BBSRC, ERC, MRC, and EPSRC an international research team, led by University of Birmingham scientists, used advanced imaging techniques to reveal that PopA has a bowl-like shape that can trap parts of the bacterial membrane inside it.

    When PopA – an outer membrane protein (OMP) – is introduced into E. coli bacteria, it causes damage to their membranes. This suggests that PopA might play a role in how Bdellovibrio attacks and consumes other bacteria, whilst its ability to trap lipids (fats) suggests a new way bacteria might interact with their surroundings.

    Structural analysis and AI-driven searches showed that PopA homologues – found across diverse bacterial species – form tetramers, hexamers, and even nonamers, all sharing the signature lipid‑trapping features. This suggests a widespread, previously unrecognised ‘superfamily’ of proteins.

    Our discovery is significant because it challenges what scientists thought they knew about bacterial proteins. The unique structure and function of PopA suggest that bacteria have more complex ways of interacting with their environments than previously understood.


    This could open new possibilities for understanding how bacteria function and interact with their environments – leading to new ways to target harmful bacteria with important implications for medicine and biotechnology.”


    Professor Andrew Lovering, Lead Author, University of Birmingham

    The study also identified another new family of proteins that form ring-like structures, further expanding our knowledge of bacterial proteins and suggesting that the mechanism to combine into rings might be more common than previously thought.

    Using a combination of X‑ray crystallography, cryo-electron microscopy, and molecular dynamics, the team demonstrated that PopA, previously known as Bd0427, forms a central lipid-trapping cavity which is unusual given that the textbook model of membrane protein formation is centred on excluding lipids.

    OMPs perform a wide range of functions including signalling, host cell adhesion, catalysis of crucial reactions, and transport of solutes/nutrients into and out of organelles within the human body. Understanding the natural variability of OMPs may have benefits ranging from antibacterial development to synthetic biology.

    Source:

    Journal reference:

    Parr, R. J., et al. (2025). A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily. Nature Communications. doi.org/10.1038/s41467-025-61633-0.

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  • Mohsin Naqvi, Sharjeel Memon discuss political issues

    Mohsin Naqvi, Sharjeel Memon discuss political issues

    Federal Interior Minister Mohsin Naqvi on Monday visited the residence of Sindh Senior Minister Sharjeel Inam Memon, where he was warmly welcomed.

    During the meeting, the two leaders engaged in a detailed discussion on the country’s prevailing political situation, inter-governmental relations, and ongoing efforts to ensure peace and stability across Pakistan.

    Interior Minister Naqvi lauded the Sindh government and police for their effective security arrangements during Muharram-ul-Haram, emphasizing the importance of maintaining law and order during the sensitive period.

    Both leaders agreed that political forces across the spectrum must come together to tackle national challenges and promote unity. They reaffirmed their commitment to strengthening coordination between the federal and provincial governments for the greater good of the country.


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