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  • RNA Blood Test Detects Early Colon Cancer with 95% Accuracy

    RNA Blood Test Detects Early Colon Cancer with 95% Accuracy


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    A new approach using RNA instead of DNA has improved the accuracy of liquid biopsy tests for early-stage colorectal cancer, according to a study by researchers at the University of Chicago. The method, which measures chemical modifications in RNA fragments from both human and microbial sources, was able to detect early disease with 95% accuracy using blood samples.

    Shifting the focus from DNA to RNA

    Liquid biopsies are diagnostic tools that detect cancer-associated genetic material in the bloodstream. Most current tests focus on circulating cell-free DNA (cfDNA), which is released by dying tumor cells. However, in early stages of cancer, tumor cells are more likely to be proliferating rather than dying, resulting in lower cfDNA concentrations. This limits the sensitivity of standard cfDNA-based liquid biopsies for early detection.

    “That has been a major challenge for early diagnosis. You just don’t have enough tumor DNA released into the blood,”


    Dr. Chuan He.

    To overcome this challenge, researchers focused on circulating cell-free RNA (cfRNA), which reflects ongoing genetic activity. RNA acts as a messenger between DNA and protein synthesis, offering a dynamic view of cellular processes. Yet, measuring RNA abundance alone is often unreliable because RNA levels can fluctuate depending on sample collection conditions.

    To address this limitation, the team measured RNA modifications – chemical changes that influence RNA behavior. Unlike total RNA levels, the proportion of modified RNA remains stable across different sample conditions. For instance, if 30% of an RNA transcript is chemically modified, that proportion is consistent regardless of the overall RNA quantity.

    RNA modification

    Chemical changes made to RNA molecules after they are produced. 

    Capturing signals from gut microbes

    Researchers also found that the cfRNA test captured signals from microbial RNA originating in the gut. These microbes, which coexist with human cells in the digestive system, release RNA fragments into the bloodstream as they die. Since microbial populations change rapidly and respond to inflammatory conditions such as cancer, the analysis of RNA modifications in microbial RNA offers an additional layer of early detection.

    “In the gut when you have a tumor growing, the nearby microbiome must be reshaped in response to that inflammation. That affects the nearby microbes.”


    Dr. Chuan He.

    The study analyzed blood samples from patients with colorectal cancer and compared them with healthy controls. Patterns of RNA modification were distinct in cancer samples, both in human- and microbe-derived RNA. These differences enabled the researchers to distinguish cancerous samples with high sensitivity.

    Improved accuracy over existing tests

    Current commercial tests based on DNA or RNA abundance, particularly stool-based ones, show reduced accuracy for early-stage disease – typically below 50%. In contrast, the new test, which evaluates RNA modification profiles, maintained nearly 95% accuracy across all cancer stages, including the earliest ones.

    This study marks the first time RNA modifications have been evaluated as biomarkers for cancer detection in a liquid biopsy context. It also demonstrates the diagnostic potential of integrating host and microbial genetic activity in a single test.

    Reference: Ju CW, Lyu R, Li H, et al. Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples. Nat Biotechnol. 2025. doi: 10.1038/s41587-025-02731-8

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

    This content includes text that has been generated with the assistance of AI. Technology Networks’ AI policy can be found here.

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  • Demna bows out at Balenciaga with star-studded final show in Paris | Balenciaga

    Demna bows out at Balenciaga with star-studded final show in Paris | Balenciaga

    Kim Kardashian modelling an off-shoulder fake mink coat inspired by Elizabeth Taylor. Nicole Kidman and Kyle MacLachlan nattering on the front row. And an appearance from Mrs Bezos herself.

    The stars were always going to align in Paris for Demna’s final show at Balenciaga. And on Wednesday lunchtime, the most controversial and copied designer in modern fashion bowed out after a decade with a show that conformed to the idea of couture as much as it challenged it.

    Backstage, Demna spoke with relief about “leaving this city that I love and hate for good” when he moves to his new job at Gucci in Milan next week. But before then, he wanted to “make couture relevant”.

    Democratising couture isn’t easy. This stuff is handmade to exacting rules and wildly expensive. But the plan was to use the show as a stage and the clothes as costumes for social commentary. Previous hot topics have included climate change, swag-wars and AI. On Wednesday it was a study of the relevant dress codes of “La Bourgeoisie” – and the moneyed few sat here who fork out for it.

    The stage itself was Cristóbal Balenciaga’s former apartment, restored to its plush 1960s cream glory when the Basque designer introduced couture in 2021.

    Demna (second from left) in June at the Paris menswear spring/summer 2026 show with (from left) Guram Gvasalia, Tori Brixx and Rich the Kid. Photograph: Pierre Suu/Getty Images

    At the glamorous end were a sugar pink debutante dress made from the world’s lightest organza, and a sequinned skirt suit based on – what else – Demna’s grandma’s kitchen tablecloth. No doubt Mrs Bezos had her eye on the elegant corset dresses which came without boning, “so you can actually breathe”, he said.

    Famous for flipping traditional notions of beauty by casting models of all ages and sizes, out came nine Neapolitan suits without shoulder pads and modelled by bodybuilders because “it isn’t the garment that defines the body, but the body that defines the garment”.

    There followed references from Demna’s greatest hits, including a seam-free puffer coat and couture trainers, while references from Cristobal’s came in the shapes and long sleeves; the show ended with a cream, bell-shaped Guipure lace gown which referenced the scale of Balenciaga’s from the 1950s.

    Few designers have had the cultural reach of Demna, who was made creative director at Balenciaga in 2016 after stints at Maison Margiela, Louis Vuitton and his own label, Vetements.

    During his career here, he has orchestrated frenzies around ordinary items such as Crocs and Ikea Frakta bags, upending the meaning of good taste while infuriating critics by whacking four-figure price tags on to distressed trainers.

    Intended as a joke and a commentary on the hierarchy of value, it proved a particularly lucrative gag for Balenciaga’s parent company, Kering, becoming a billion-dollar megabrand.

    For some, Demna never recovered from allegations that he had condoned child exploitation in a series of ads involving BDSM imagery and children in 2022. At the time, he took responsibility, although the scandal dented both hype and sales for some time.

    Ultimately, it predicated a move away from his more viral designs, which had begun to distract, and he became more focused on his skills as a designer.

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    He is succeeded by the relatively safer designer, Valentino’s Pierpaolo Piccioli. Demna’s back catalogue will continue to polarise, but his legacy is indisputable. As Demna said: “I’m so hard on myself – but I could not do better than this at Balenciaga.”

    Was this Giorgio Armani’s last ever collection? Last month, for the first time in the designer’s history, the designer missed his Milan shows due to to ill health.

    The plan had been a precautionary one, a rest before this show. So a no-show from the designer at his show at the company headquarters this week, coupled with visibly emotional models ambling like Erté sketches down the catwalk, certainly sent tongues wagging.

    In an attempt to stop the rumour mill, the 90-year-old designer explained his absence to a handful of reporters in an email: “Even though I wasn’t in Paris, I oversaw every aspect of the show remotely via video link, from the fittings to the sequence and the makeup”. His absence, he said, was at the behest of his of his doctors: “Although I felt ready to travel, they recommended extending my rest.”

    Regardless of whether you could afford an Armani suit, one of his legacies has been encouraging women to wear trouser suits. And at the show, among the sculptural peplums and slithery gowns with oversized bows, came tuxedos in funereal black. Ostensibly glamorous versions of the menswear he began in the 1980s, there was also a finality to them.

    Keen to control the narrative of his £10bn Armani empire, of which he is a sole shareholder, he was quick to remind us that “everything [we saw] … has been done under my direction and carries my approval”.

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  • NASA’s Parker Solar Probe Finds Evidence Of “Helicity Barrier” In The Sun’s 2 Million Kelvin Atmosphere

    NASA’s Parker Solar Probe Finds Evidence Of “Helicity Barrier” In The Sun’s 2 Million Kelvin Atmosphere

    A study looking at data from NASA’s Parker Solar Probe has found evidence for a “helicity barrier” in the atmosphere of the Sun.

    In 2018, NASA launched the Parker Solar Probe on a trajectory that would eventually have it dive into the Sun’s atmosphere (corona), getting seven times closer to our host star than any other spacecraft so far. In June 2025, the probe completed its 24th close approach to the Sun, whilst equaling its record for the fastest a human-made object has ever traveled, at a zippy 692,000 kilometers per hour (430,000 miles per hour).

    The probe is aimed at studying the Sun’s atmosphere and will hopefully shed light on a few long-standing mysteries, such as how the solar wind is accelerated. One puzzle, first discovered in 1939, is that the Sun’s corona is far hotter than the solar surface. And not just by a little.

    “The hottest part of the Sun is its core, where temperatures top 27 million °F (15 million °C). The part of the Sun we call its surface – the photosphere – is a relatively cool 10,000 °F (5,500 °C),” NASA explains. “In one of the Sun’s biggest mysteries, the Sun’s outer atmosphere, the corona, gets hotter the farther it stretches from the surface. The corona reaches up to 3.5 million °F (2 million °C) – much, much hotter than the photosphere.”

    This is known as the “coronal heating problem”. The basic problem is this: why is the atmosphere far hotter than the surface, when the surface is much closer to the core, where energy is generated through the fusion of hydrogen into helium? 

    There have been suggestions that the extra heat in the corona is caused by turbulence, or a type of magnetic wave known as “ion cyclotron waves”.

    “Both, however, have some problem—turbulence struggles to explain why hydrogen, helium and oxygen in the gas become as hot as they do, while electrons remain surprisingly cold; while the magnetic waves theory could explain this feature, there doesn’t seem to be enough of the waves coming off the sun’s surface to heat up the gas,” Dr Romain Meyrand, author on the new paper, explained in a previous statement.

    While both ideas have problems, together with a “helicity barrier”, they show some promise for explaining the coronal heating problem.

    “If we imagine plasma heating as occurring a bit like water flowing down a hill, with electrons heated right at the bottom, then the helicity barrier acts like a dam, stopping the flow and diverting its energy into ion cyclotron waves,” Meyrand added. “In this way, the helicity barrier links the two theories and resolves each of their individual problems.”

    Essentially, the helicity “barrier” alters turbulent dissipation, changing how fluctuations dissipate and how the plasma is heated. The team has now analyzed data from the Parker Solar Probe, and it appears to show evidence for the helicity barrier.

    “The barrier can form only under certain conditions, such as when thermal energy is relatively low compared to magnetic energy. Since fluctuations in the magnetic field are expected to behave differently when the barrier is active versus when it is not, measuring how these fluctuations vary with solar wind conditions relevant to the barrier’s formation—including the thermal-to-magnetic energy ratio—provides a way to test for the barrier’s presence,” the team explains in their paper. 

    “By analyzing solar wind magnetic field measurements, we find that the fluctuations behave exactly as predicted with changes in solar wind parameters that characterize these conditions. This analysis also allows us to identify specific values for these parameters that are needed for the barrier to form, and we find that these values are common near the Sun.”

    Further analysis is necessary, but the approach looks fairly promising for explaining the problem.

    “This paper is important as it provides clear evidence for the presence of the helicity barrier, which answers some long-standing questions about coronal heating and solar wind acceleration, such as the temperature signatures seen in the solar atmosphere, and the variability of different solar wind streams,” Dr Christopher Chen, study author and Reader in Space Plasma Physics at Queen Mary University of London, said in a statement.

    “This allows us to better understand the fundamental physics of turbulent dissipation, the connection between small-scale physics and the global properties of the heliosphere, and make better predictions for space weather.”

    While conducted on our own Sun (we are far from ready to plunge spacecraft into the atmosphere of other stars), the study has implications for other stars, and other parts of the universe, in other collisionless plasmas.

    “This result is exciting because, by confirming the presence of the ‘helicity barrier’, we can account for properties of the solar wind that were previously unexplained, including that its protons are typically hotter than its electrons,” said Jack McIntyre, lead author and PhD student from Queen Mary University of London.

    “By improving our understanding of turbulent dissipation, it could also have important implications for other systems in astrophysics.”

    The study is published in Physical Review X.

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  • In a first, enamel proteins 18-20 million years old from tropical, High Arctic sites unravel palaeobiology of extinct taxa

    In a first, enamel proteins 18-20 million years old from tropical, High Arctic sites unravel palaeobiology of extinct taxa

    If obtaining sequences from ancient proteins found in fossils was previously limited to samples no older than four million years, two studies published in the journal Nature on Wednesday (July 9, 2025) have pushed back this timescale to more than 20 million years. The enamel proteins from extinct mammals are a staggering ten-fold older compared with the oldest known ancient DNA that has been obtained so far. The studies have used proteins or peptides trapped within dense enamel of the mammal teeth to study palaeoproteomics and to obtain phylogenetic information of extinct mammals.

    One study is of enamel proteins from extinct mammal fossils from the Turkana Basin in Kenya, and the other study is of enamel proteins from extinct mammals in the Haughton impact crater site located on Devon Island, Nunavut in far Northern Canada.

    “The two papers have redefined the boundaries of biomolecular preservation in the fossil record,” says Dr. Niraj Rai, Head of the Ancient DNA Lab at the Birbal Sahni Institute of Palaeosciences (BSIP) in Lucknow, who is not part of the two studies. “These findings confirm that enamel — a highly mineralised and durable tissue that serves as an extraordinary molecular archive — is capable of preserving endogenous peptides far beyond the temporal limits of ancient DNA, which typically degrades within a million years.”

    If recovering evolutionary-informative protein sequences from samples 18 to over 20 million years old is by itself remarkable, recovering well-preserved protein samples of extinct mammals 18 million years old from the Turkana Basin in Kenya, which is a hot tropical site, is even more astounding. Unlike in cold climatic conditions, the possibility of finding well-preserved DNA and proteins dating back millions of years in one of the hottest regions in the world is slim. As a rule, molecular breakdown happens over time, which is exacerbated in a hot climate.

    A view of the Turkwel River in Turkana, northern Kenya, where the fossils from which ancient peptides were recovered are found.
    | Photo Credit:
    Daniel Green

    The second study is on protein samples encased deep within the teeth enamel found in fossil samples collected from the Haughton impact crater site located on Devon Island, Nunavut in far Northern Canada. The researchers extracted and sequenced ancient enamel proteins from a fossilised rhino tooth that are 21-24 million years old. They recovered partial sequences of seven different enamel proteins and over 1,000 peptides.

    A recent study of an ancient Egyptian who lived 4,500-4,800 years ago as well the two current studies on extinct mammals have relied on teeth samples to obtain genetic and phylogenetic information, respectively; teeth samples have turned out to be invaluable in preserving almost intact DNA and proteins. DNA found at the root tip of teeth of the ancient Egyptian allowed researchers to sequence the whole genome of the ancient man. Now, two separate teams have successfully used proteins encased within dense enamel of teeth of different mammals to interpret the biology and evolution of mammals that lived 18-24 million years ago in completely different climatic settings — frigid cold and hot tropics.

    Proteins not inferior to DNA

    Explaining that not just DNA but proteins too can reveal vital information about ancient animals, Dr. Timothy P. Cleland in an email to The Hindu says: “Proteins are translated from DNA so it can provide similar information. We can learn a wide variety of information from studying proteins from ancient animals.” Dr. Cleland, a Physical Scientist at the Smithsonian Museum Conservation Institute, Suitland, Maryland, and one of the corresponding authors of the East African Rift paper, cites the example of an enamel protein called amelogenin which has X-linked and Y-linked forms that can be used to estimate biological sex of the mammal being studied. The enamel proteins have more evolutionary information than collagen (for example) and can be used to evaluate the evolutionary relationships of fossil species beyond morphology alone, he says.

    Dr. Ryan Sinclair Paterson in an email says that he would not say either palaeoproteomics or palaeogenomic data is more reliable than the other, when it comes to studying living organisms. Dr. Paterson is from Globe Institute, University of Copenhagen, Copenhagen, Denmark, and the first and a corresponding author of the paper on the discovery of teeth enamel of Rhinocerotinae in the Haughton impact crater site, Nunavut in far Northern Canada. “Genomic data can have a higher resolution, and be more useful for finer aspects, particularly of relatedness amongst closely-related lineages. Proteomic data can also be very useful for resolving very deep splits in the tree of life, as they are thought to be less prone to convergence and saturation,” he says.

    Dr. Paterson further adds: “With these ancient proteins, while they lack the resolution of DNA, they still represent robust genetic sequence data, carrying mutations that can allow for sequence-based timetrees. I think that is the major goal of this type of palaeoproteomic study – filling in the tree of life across vast geological timescales using genetic sequence data.”

    Both teams extracted key structural enamel proteins, enamelin, ameloblastin, and amelogenin using advanced mass spectrometry and rigorous criteria to rule out contamination. Remarkably, diagenetic alterations once considered damaging, such as advanced glycation end-products and carbamylation in the Kenyan samples, or widespread arginine oxidation and peptide bond hydrolysis in the Arctic specimen, are now leveraged as hallmarks of authenticity, says Dr. Rai.

    “The study of enamel proteins from fossils has been an exciting area of research for the last several years, and has benefited from new extraction methods, improvements in mass spectrometry methods, and data analysis tools. We took advantage of all of these developments to find preserved proteins from mammal enamel from the Turkana Basin of Kenya,” says Dr. Cleland.

    The Turkana Basin has produced the richest record of mammal evolution in eastern Africa in the current geological era — the Cenozoic Era — spanning the last 66 million years. The researchers had examined protein fragments ranging from 1.5-million-year-old elephant fossils to 29-million-year-old fossils from Arsinoitheriidae, a family of extinct, rhinoceros-like ungulates. The Turkana Basin has been found to document the evolutionary origins and/or diversifications of key taxonomic groups of African mammals, such as proboscideans, rhinocerotids, hippopotamids and hominoids (great apes).

    View of the Haughton Formation near Rabbit Run creek on Devon Island, Nunavut. The dry, cold “polar desert” conditions helped preserve the ancient rhinoceros fossil found here, including traces of original proteins.

    View of the Haughton Formation near Rabbit Run creek on Devon Island, Nunavut. The dry, cold “polar desert” conditions helped preserve the ancient rhinoceros fossil found here, including traces of original proteins.
    | Photo Credit:
    Martin Lipman

    Shielding the embedded proteins

    Explaining how the proteins had escaped complete destruction during the last 18 million years despite the hot climate and diagenesis — the physical and chemical changes that occur during the conversion of sediment to sedimentary rock — at the Turkana Basin, Dr. Cleland says: “Because the proteins are essentially self-fossilised within the enamel mineral, they are protected from other environmental impacts that could lead to their loss.” Going further to explain how the enamel proteins are protected even for millions of years, he says: “Enamel is the hardest substance that animals produce and shields the embedded proteins from access to water or microbial impact, so it begins as a good place to find the preserved proteins.” The researchers had sampled the internal part of the enamel that is fairly thick in these species, so it is unlikely that protein from elsewhere would be deposited on the enamel.

    Despite building the study to have a range of ages from 1.5 million years to 29 million years to explore the preservation of enamel proteins across a long-time range, the researchers of the Turkana Basin in the East African Rift System were “surprised and excited to find proteins that retained evolutionary information all the way to 18 million years”.

    Though the hot climate is not conducive for protein preservation for millions of years, the Turkana Basin also has fluviodeltaic sediments, which might have led to swift burial of ancient animals, thereby resulting in relatively well-preserved fossil samples. The findings from the Turkana Basin also suggest that this could have been the case. “Relatively more proteins are found in some sites that we study, compared to others. For instance, we find an especially high number of peptides from fossils at a very old site, Buluk. Sedimentary data suggest that Buluk fossils were buried rapidly, and this may be why protein preservation is better there,” Daniel R. Green from the Department of Human Evolutionary Biology, Harvard University, and the first and one of the corresponding authors of the East African Rift paper tells The Hindu in an email.

    Swift burial may have played a role in preserving the proteins even in the case of the Haughton impact crater site located on Devon Island, Nunavut, where it was a lake. “Swift burial can help with preservation of bones and teeth under the right conditions. Specifically, we expect exceptional preservation when there is both rapid burial and low oxygen or anoxic conditions. There may have been some low oxygen conditions in the Haughton Lake, as mummified wood has been discovered. So, it’s possible that this contributed to the exceptional preservation. However, it is most likely related to the cool temperatures, specifically preservation in permafrost. Interestingly, a lot of bones from the Haughton Crater end up broken due to the repeated freeze and thaw of the permafrost. Some are also brought to the surface by this freeze and thaw action, making them easier to find,” Dr. Danielle Fraser from Palaeobiology, Canadian Museum of Nature, Ottawa, Ontario, Canada and one of the corresponding authors of the paper says in an email to The Hindu.

    The team has collected a large amount of data from all of these sites across northern Kenya, which includes information about ancient climatic conditions as estimated through Earth System Climate Models. “We have reconstructed vegetation and rainfall through soil chemistry analyses. And we can make inferences about ancient diets, behaviours, and evolutionary processes through the fossils themselves, and their stable isotope compositions,” says Dr. Green.

    According to Dr. Frazer, finding intact teeth, which are identifiable, is not surprising, given that there are teeth from mammals dating back many more millions of years into the Mesozoic. “What is exceptional, is that the proteins we recovered were complete and abundant enough to infer evolutionary relationships; these are, by about 10 million years, the oldest from which evolutionary information has been gleaned,” he says. “Specifically, we were able to test a hypothesis about the evolution of rhinocerotids (rhinoceroses and their extinct relatives), a group whose past diversity was much greater than today. What recovering such evolutionarily informative proteins from this fossil tells us is that we will be able to test many more hypotheses using many more fossils from the Arctic and, perhaps, challenge some other long-held evolutionary hypotheses along the way.”

    The Haughton Crater has been studied for decades to understand the depositional environment, the plant community, the date of the formation of the crater (based on several types of exact dating), the mammal fauna etc. “What we know is that the environment was fundamentally different from the modern Arctic, being much more temperate, and that the mammal fauna was unique, being a combination of species with North American and Eurasian affinities,” says Dr. Frazer.

    He is very hopeful that we will see evolutionarily informative proteins extracted from older [more than 24 million years] materials and expects them to be found in Arctic or Antarctic conditions, where they have been preserved in a “freezer” for many millions of years.

    The authors of the Haughton impact crater site located on Devon Island, Nunavut in far Northern Canada used the protein sequences to shed light on the divergence between the two main subfamilies of rhinos, Elasmotheriinae and Rhinocerotinae. Based on protein sequences, they revised the rhinocerotid phylogeny, showing that Epiaceratherium diverged prior to the Elasmotheriinae-Rhinocerotinae split, contradicting fossil-based models that suggested a deeper basal divide.

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  • Cyberpunk 2077 Hits the PlayStation Plus Games Catalog

    Cyberpunk 2077 Hits the PlayStation Plus Games Catalog

    CD PROJEKT RED today announces that its best-selling open-world role-playing game Cyberpunk 2077 is now available in the PlayStation Plus Games Catalog.

    PlayStation Plus Extra and Premium members can play through the entirety of the Cyberpunk 2077 base game at no extra cost on PlayStation 4 and PlayStation 5. Players become V, a cyber-enhanced mercenary ready to do whatever it takes to make a name for themselves in the dark future of Night City — a megalopolis obsessed with power, money, and body modifications. Cyberpunk 2077 features a gripping main story, starring Keanu Reeves as Johnny Silverhand, alongside myriad side quests, gigs, and more for players to explore.

    The PS5 version has been enhanced with 4K visuals, ray tracing, and 3D audio, alongside DualSense exclusive features including adaptive triggers and haptic feedback. The PS5’s ultra-high speed SSD also allows for quick load times when exploring the open world, and players here will gain access to the Cyberpunk 2077 base game alongside each update released since launch — which enhance gameplay with new missions, vehicles, quality-of-life features, and more — alongside the upcoming Update 2.3 upon its release. Those on PS4 will receive the base game and every update released for that version, up to and including the Edgerunners Update.

    More information about Cyberpunk 2077 can be found on the official website, Facebook, Instagram, Bluesky, and X.


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  • Pakistan’s actions to root out terrorism globally recognised, says Bilawal

    Pakistan’s actions to root out terrorism globally recognised, says Bilawal



    Pakistan Peoples Party Chairman Bilawal Bhutto-Zardari addresses a press conference. — AFP/File

    Pakistan Peoples Party (PPP) Chairman and former foreign minister Bilawal Bhutto-Zardari categorically rejected the India’s allegations of patronising terrorist groups, saying that the country had successfully cleared the rigorous FATF process.

    In an interview with Indian journalist Karan Thapar, Bilawal said: “Pakistan does not willingly permit […] the groups you mentioned or any group to conduct terrorist attacks outside of Pakistan but also within Pakistan.”

    Highlighting the country’s losses during the war against terrorism, the PPP lawmaker said that the world is well aware that Pakistan faced the brunt of terrorism over the past many decades.

    “Pakistan is fighting and has been fighting the largest inland war against terrorism. We’ve lost 92,000 lives altogether. Just last year, we lost more than 1,200 civilian lives in more than 200 different terrorist attacks.”

    “At the rate at which terrorist attacks are taking place just this year alone, if they continue at this pace, this year will be the bloodiest year in Pakistan’s history.”

    Recalling the assassination of his mother and former premier Benazir Bhutto, Bilawal said: “I too am a victim of terrorism. I feel the pain of the victims of the Pahalgam terrorist attack. I understand the trauma that their families are experiencing in a way more than many others can ever imagine.”

    He also elaborated on Pakistan’s ongoing battle to root out the menace, saying: “Pakistan went through a process where we not only took military action against terrorist groups within Pakistan.”

    He said that in the previous Zardari’s tenure, Pakistan conducted an operation in South Waziristan following Benazir’s assassination, and the next government conducted another operation in North Waziristan.

    ‘Rigorous’ FATF process

    “We implemented a National Action Plan as far as our actions against the groups of concern to India. Most recently, we went through a rigorous FATF [Financial Action Task Force] process.”

    He added that the international community was very well aware and endorsed Pakistan’s actions against said terrorist groups.

    Bilawal added that the FATF is a very rigorous process that has a complete monitoring mechanism, so it’s not like you can hide from it.

    Slamming the Indian allegations, Bilawal said that immediately after the Pahalgam attack, Prime Minister Shehbaz Sharif publicly stated that Islamabad is “willing to be part of any impartial international inquiry into the incident, our hands are clean.”

    “We had that sort of confidence. It was the Indian government that rebuffed that offer. To this day, the Indian government has not shared with Pakistan or the international community.”

    Pakistan and India engaged in a military confrontation in May, triggered by April’s Pahalgam attack in Indian Illegally Occupied Jammu and Kashmir (IIOJK). Pakistan has denied involvement in the attack.

    Bilawal had also led a parliamentary delegation that visited global capitals on a mission to debunk the Indian propaganda in the aftermath of the recent conflict between the two countries.

    The nuclear-armed rivals used missiles, drones, and artillery fire during the four-day fighting —their worst in decades — before agreeing to a ceasefire.

    In response to the Indian aggression, Pakistan’s armed forces launched a large-scale retaliatory military action, named “Operation Bunyan-um-Marsoos”, and targeted several Indian military targets across multiple regions.

    The ceasefire was first announced by US President Donald Trump on social media after Washington held talks with both sides, but India has differed with Trump’s claims that it resulted from his intervention and threats to sever trade talks.

    However, Pakistan has acknowledged Trump’s efforts and formally recommended him for the 2026 Nobel Peace Prize, citing his role in defusing tensions between Pakistan and India last month.

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  • Take Up to 52% Off AirPods, Apple Watches & More

    Take Up to 52% Off AirPods, Apple Watches & More

    Best Prime Day Apple Deals on Day 2:


    Apple doesn’t typically offer discounts across its tech line-up, which means that you’ll need to head to third-party sites like Amazon to find them. With thousands of products now discounted across the site for Prime Day, it’s one of the best opportunities of the year to land savings on the tech giant’s offerings, and there’s already plenty of Prime Day Apple deals to bank across AirPods, Apple Watches, Beats headphones and more.

    Shop Apple Prime Day Deals Amazon

    If you’re thinking about upgrading your smartwatch or fitness tracker, there’s discounts on all three of the latest Apple Watch models. The flagship Apple Watch Ultra 2 is a hefty £140 off, down from to £799 to £659, the everyday powerhouse Apple Watch Series 10 has dipped under £300 – now just £295, down from £399. The latest entry-level Apple Watch SE is also discounted, with £34 slashed off its ordinary price this Prime Day.

    There’s also plenty of opportunities for an audio upgrade. You can now grab the AirPods Pro 2 and AirPods 4 for less, reduced by £50 and £30 respectively. Because Beats is owned by Apple, we’ve also included deals on the new workout-leaning Powerbeats Pro 2 – down from £249.99 to £185.25 – and the older, but still excellent, Beats Fit Pro, which are over £110 off at £108.30. Here’s a round-up of the all these, plus more of the best Apple Prime deals we’ve found so far, including more offers on iPads, iMacs and iPhones.

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    When Does Prime Day End?

    If you’ve been holding out for a bargain before picking up a new Apple smartwatch, tablet, smartphone or earbuds, the clock is now ticking. You have 96 hours from the start of the sale to make the most of these deals before it ends at midnight on Friday 11 July.

    Do You Need a Prime Membership to Take Part?

    Yes. To make use of these Apple Prime Day deals, plus all the other offers included in the event this week, you’ll need to either already be a Prime member or you can join for free by signing up to a 30-day free trial, which you can cancel for no fee once the sale ends after midnight on Friday.

    More Fitness Tech Deals and Reviews

    Prime Day Deals 2025 | Prime Day Headphone Deals | Prime Day Garmin Deals | Best Apple Watches | Apple Watch Ultra 2 Review | Beats Powerbeats Pro 2 Review | Beats Fit Pro Review | Best Beats Headphones | Best Gym Headphones

    Headshot of Luke Chamberlain

    Luke Chamberlain is the ecommerce editor for Men’s Health UK where he compiles expert-led buying guides and in-depth product reviews across gym wear, fitness tech, supplements, and grooming. Responsible for testing everything from the latest gym headphones to the best manscaping tools, Luke also enlists the help of leading health and wellness experts to help readers make informed choices when shopping online – whether it’s to debunk the latest viral hair growth trend or to get the lowdown on a new type of recovery tech. He also covers major sales events for Men’s Health, such as Black Friday and Amazon Prime Day, scouting and verifying hundreds of discounts in order to recommend only the most genuine deals on offer. A magazine journalism graduate from the University of Sheffield in 2018, Luke has also worked as assistant editor for Outdoor Swimmer magazine and as an ecommerce writer for The Recommended. When he’s not testing the latest health and fitness products, he’s busy plotting routes for his next trail run or gravel ride out of London. Follow Luke on Instagram at @lukeochamb


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  • Sacked Bath hospital surgeon loses unfair dismissal claim

    Sacked Bath hospital surgeon loses unfair dismissal claim

    Carys Nally

    BBC News, West of England

    BBC Mr Colbert stands in a hospital operating room, wearing blue scrubs and surgical hat. Two members of staff, also in scrubs, can be seen over his left shoulder looking at a screen.BBC

    Seryth Colbert has lost an employment tribunal after claiming he was unfairly dismissed

    A surgeon from Bath has lost an employment tribunal after claiming he was unfairly dismissed for whistleblowing about patient safety concerns.

    The tribunal panel found Seryth Colbert, a consultant in oral and maxillofacial surgery, was sacked from the Royal United Hospital in Bath due to his behaviour, not the content of his concerns.

    The surgeon argued he had been subjected to detriment for exercising his rights under the Public Interest Disclosure Act (PIDA).

    The Bristol Employment Tribunal panel dismissed his claim and concluded his behaviour with some colleagues was unacceptable, with judgement issued on 30 May. Mr Colbert is planning to appeal against the decision.

    The surgeon claimed his dismissal in October 2023 was due to retaliatory victimisation, leading to the tribunal.

    This came after he raised concerns, which included allegations that cancer patients were not being treated and that a patient had been blinded during surgery.

    In October 2023, a disciplinary panel upheld 11 out of 14 allegations against Mr Colbert, leading to his dismissal.

    These included: bullying and aggressive behaviour, unwanted physical contact, undermining management, inappropriate use of trust processes and rude and dismissive communication.

    The employment tribunal panel found: “Some of this conduct is more serious than others. An isolated rude email is clearly insufficient to warrant summary dismissal.

    “Low level unwanted physical contact might also be regarded as somewhat innocuous.”

    Plans for appeal

    The panel added: “Similarly, the fact that the claimant raised issues brought to him by junior doctors with someone other than the clinical lead in the department, may seem a long way from repudiatory conduct.

    “However, once the context, intention and impact are considered, the conduct, taken collectively, does, we conclude, amount to repudiatory breach.

    “The claimant acted in a way which was coercive to junior colleagues, undermined a senior colleague and was intimidating.

    “Although, there is no doubt at all, that his treatment of other colleagues was exemplary, beneficial and inspiring, that does not detract from our findings.”

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  • EUDR saga: Parliament votes to undermine enforcement and EU credibility – WWF EU

    1. EUDR saga: Parliament votes to undermine enforcement and EU credibility  WWF EU
    2. EU countries seek more cuts to deforestation rules, letter shows  Reuters
    3. Stop complaining, start complying! The EUDR must apply as planned on 30 December 2025  greenpeace.org
    4. Cadbury-maker Mondelez calls for EUDR deforestation law delay  New Food magazine
    5. Indonesia warns EU deforestation rules threaten small farmers, exports  Indonesia Business Post

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  • Lioness Lucy Bronze uses ‘cycle syncing’ to get an edge on her competition — here’s how the practise works

    Lioness Lucy Bronze uses ‘cycle syncing’ to get an edge on her competition — here’s how the practise works

    England footballer Lucy Bronze recently said in an interview that “cycle syncing” gives her an edge on the pitch. This practice involves aligning your training schedule to the different phases of your menstrual cycle.

    Cycle syncing has become increasingly popular in recent years – especially among athletes who are looking to get an edge over the competition. Even Chelsea women’s football team have put this new approach to use, tailoring training schedules according to each player’s menstrual cycle.

    For the average person, tailoring your workouts to your menstrual cycle is probably not going to have much of an impact. But for a professional athlete such as Bronze, cycle syncing could be a gamechanging strategy in shaping her elite performance.


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    The menstrual cycle begins and ends with menstruation (a period). While the length of the menstrual cycle varies for each person, it’s usually around 28 days.

    The menstrual cycle is underpinned by fluctuations in levels of the female sex hormones oestrogen and progesterone. This is why the cycle is divided into three key phases: early follicular, late follicular and the luteal phase.

    The early follicular phase usually lasts around seven days and begins with the start of your period. This is when hormone levels are at their lowest.

    The late follicular phase follows on from the first seven days, and is where ovulation happens – usually around day 14 of the cycle, though this will depend on cycle length. Ovulation is when the egg is released and you’re at your most fertile.

    After that comes the luteal phase (lasting around 12-14 days), when progesterone peaks to prepare the body for pregnancy. If pregnancy doesn’t happen, hormones drop and the cycle begins again.

    It’s no secret that mood and energy levels can shift – sometimes significantly – throughout the menstrual cycle. This is why some female athletes have begun using cycle syncing. By tailoring training schedules to match hormonal fluctuations, women are gaining a deeper understanding of their bodies and the symptoms they experience throughout each phase – empowering them to train smarter, not harder.

    Bronze said the strategy has transformed her performance, saying that during certain phases of her cycle she feels “physically capable of more and can train harder”.

    Despite these testimonials, scientists are yet to reach a definitive conclusion on how the menstrual cycle affects athletic performance.

    Lucy Bronze smiles during a match.
    Bronze is just one of many female athletes putting ‘cycle syncing’ to the test.
    Christian Bertrand/ Shutterstock

    So far, there’s some suggestion that there may be a slight dip in performance (specifically to strength and endurance) during the early follicular phase. However, these effects are minimal – and highly dependent on the person. It’s also not entirely clear what mechanisms underpin these small performance dips that some women experienced.

    Other research suggests that certain aspects of the neuromuscular system (the network of nerves and muscles that make movement possible) – specifically how our muscles generate force – is altered during the luteal phase. Research has also found that certain muscles may fatigue less quickly during this phase as well.

    This implies that during the luteal phase, there may be changes in signals from the brain and spinal cord to the skeletal muscles. However, no changes in the neuromuscular function have been observed.

    Part of the reason it’s so difficult for researchers to gather enough evidence to draw firm conclusions on the menstrual cycle’s potential effects on athletic performance is because of the huge variability in menstrual cycle characteristics, which makes it difficult to study. Phase length, hormone levels and symptoms can differ widely between women – and even from cycle to cycle.

    The small effects seen in these studies will have little effect on how most of us train or exercise. But for an elite athlete, these minuscule differences could have an effect on their training and competition, which may be why so many are willing to give the practice a try.

    So while it isn’t entirely clear how much influence certain menstrual cycle phases have on performance, how you feel during different phases could certainly affect your ability to train at your best.

    Around 77% of female athletes experience negative symptoms in the days leading up to and during menstruation. Fatigue, feeling less motivated and even experiencing digestive issues such as bloating and nausea, could all affect your ability to train at your best.

    Trying cycle syncing

    If you’re still interested in giving cycle syncing a try to see if it has any effect for you, the best place to start is by tracking your menstrual cycle. This will help you understand your body, how you feel in each phase of your cycle and what effect certain symptoms have on your training.

    It’s recommended you track your cycle for at least three months before making any changes to your training to establish a baseline and spot trends over time.

    For example, if you notice you often feel fatigued when training in your luteal phase, it may help to focus on ensuring you fuel well with carbohydrates before and during workouts. Or on days where you feel more energetic and motivated to train, you might be able to push yourself a bit harder in your workouts.

    Whether you’re playing for England in the Euros or simply working towards your own fitness goals, understanding your cycle can help you train smarter, manage your symptoms better and stay consistent with your training.

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