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  • Best Movies Streaming in August 2025: ‘Final Destination Bloodlines’

    Best Movies Streaming in August 2025: ‘Final Destination Bloodlines’

    The Halloween season is still a couple months away, but some of the year’s buzziest horror movies of 2025 aren’t waiting to make their streaming debuts. “Final Destination Bloodlines,” which became the long-running horror franchise’s highest-grossing entry yet with $285 million this summer, debuts on Max this August, while Neon’s “The Monkey,” the latest horror endeavor from “Longlegs” filmmaker Osgood Perkins, heads to Hulu. Shudder is also debuting its twist-filled, indie horror favorite “Clown in a Cornfield” on streaming this month.

    For non-horror lovers, Netflix has Sofia Carson’s latest original romance (“My Oxford Years”), Max has A24’s family fantasy adventure “The Legend of Ochi,” and Prime Video has an original comedy that pairs Eddie Murphy and Pete Davidson (“The Pickup”).

    Check out a full rundown below of the biggest movies new to streaming platforms in August.

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  • Ready to Prescribe a GLP-1 Medication? Please Dive Deep Into the Patient’s History First, Advises John Bonnet, MD,

    Ready to Prescribe a GLP-1 Medication? Please Dive Deep Into the Patient’s History First, Advises John Bonnet, MD,

    As the use of glucagon-like peptide-1 receptor agonists (GLP-1s) for management of overweight and obesity continues to grow, an increasingly bright light is revealing that pharmacotherapy alone is not sufficient to achieve long-term weight loss success. The incretin-based antiobesity medications don’t work in a vacuum and without the support of individualized and intentional lifestyle strategies, patients may not realize the full benefits of treatment, could experience avoidable adverse effects, or even abandon treatment altogether.

    Jonathan Bonnet, MD, MPH, is coauthor of a new joint advisory titled “Nutritional Priorities to Support GLP-1 Therapy for Obesity,” a collaboration among members of the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. The multidisciplinary guidance for clinicians managing patients on GLP-1s for obesity covers a wide range of therapeutic considerations, including how to manage the ubiquitous GI side effects, how to protect against muscle loss, and the importance of monitored protein intake and resistance training as standard parts of the treatment plan.

    In a recent interview with Patient Care©, Bonnet focused specifically on the critical role of a thorough, detailed initial patient history for a successful weight loss outcome. Before even considering a GLP-1 medication prescription, a clinician must understand the patient’s history with weight loss and weight gain, dieting, emotional relationship with food, impact of life events on body weight, exercise preferences, and so much more. In the short video above, Bonnet details the elements of a comprehensive history and explains why each is essential to creating an individualized weight management program with the greatest opportunity for success.


    Jonathan Bonnet, MD, MPH, is the program director of medical weight loss at the Clinical Resource Hub Weight Management Center at Palo Alto Veteran’s Affairs in Palo Alto, California. He is also an associate professor (affiliate) at Stanford University School of Medicine, and serves on the board of the American Board of Lifestyle Medicine. Bonnet is board-certified in family, sports, obesity, and lifestyle medicine.


    The following transcript has been lightly edited for style and flow.

    Patient Care: So an essential starting point, the advisory says, before you begin prescribing a GLP-1 is to do a really thorough baseline nutritional assessment and screening. Is this an element of clinical management that you think could be overlooked before GLP-1s are started?

    Johnathan Bonnet, MD, MPH: It’s challenging because I do obesity medicine as a specialty, so I have more time to focus on patients and really dive into their history. But there are really critical pearls that you would want to get, even if you’re a primary care doctor. So understanding what a person’s weight loss or weight gain journey has been is essential, and includes understanding key triggering events or times in life, or if starting a medication caused a weight change.

    If people have a history of eating disorders and honestly, it’s not overly difficult to develop a disordered eating pattern if people are trying to do very extreme things. That can lead to nutrient deficiencies. So a lot of it is really understanding the history of the patient and what has gotten them to the state that they are in.

    You also have to understand what is driving their obesity? Is it sleep deprivation? Is it overconsumption of ultra-processed foods? Lack of activity? Is it medications? Is there a mental health problem, like underlying depression, anxiety, something else, that’s really driving a lot of the increased food intake and weight gain? And if you don’t take the time to understand those things, you’re just throwing out a drug that’s going to reduce appetite without necessarily addressing some of the foundational problems that could be causing this in the first place.

    [Without this history] I think you’re also missing the point. We’re here to help improve the health of patients, right? And weight is one thing, and obesity is a chronic condition, but there’s also so much more wrapped into what good health is. And again, addressing all those other factors, the lifestyle factors, is, I would say, equally important to make sure we get it right.

    So again, just to give somebody a drug just because you see an elevated BMI would really be a mistake. There are also some contraindications and things to using the drugs as well. There are a few medication interactions. So you could easily miss those if you’re not being thoughtful. All those are part of a comprehensive history you want to take with a patient before you prescribe an antiobesity drug for them.


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  • H5N1 in cows retains preference for infecting birds – Feedstuffs

    1. H5N1 in cows retains preference for infecting birds  Feedstuffs
    2. H5N1 found in dairy cattle retains preference for infecting birds, representing low risk to humans  St. Jude Children’s Research Hospital
    3. Dairy to poultry: Tracking avian influenza’s path  Feedstuffs
    4. Dairy cattle H5N1 virus remains adapted to birds, with little sign of human spread  Medical Xpress

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  • Collagen Decline Affects More Than Just Your Skin

    Collagen Decline Affects More Than Just Your Skin

    Collagen decline begins quietly. Like a WhatsApp group you once loved that now only sends birthday messages. One day, you’re bouncing out of bed with springy knees and plump skin, the next, your joints make new and unsettling noises. Your hair tie wraps around three times instead of two.

    What gives? Well, collagen: the protein shaping your face, bracing your joints and bolstering your hair from the root, which begins to decline in production during your mid-20s.

    So it’s no wonder collagen is having a moment. We’re stirring it into coffee, sipping it between meetings, popping tablets of it like candy.

    What is collagen?

    Collagen is the most abundant protein in our bodies. Think of it as the biological glue that keeps your features firm, your body upright, and your bounce intact. Humans have at least 28 types, but Types I, II and III are the headliners:

    • Type I: Skin, bones, tendons, ligaments, accounts for 90% of the body’s collagen
    • Type II: Cartilage and joints
    • Type III: Skin, blood vessels, internal organs

    Your body makes collagen by combining amino acids from protein-rich foods with help from vitamin C, zinc, and copper. But from your mid-to-late twenties onwards, production begins to dip by about 1% a year.

    As Dr Rinky Kapoor, consultant dermatologist at The Esthetic Clinics, tells Vogue: “The decrease is 1% every year post your 20s, and when you reach your 40s, the production dwindles even further, displaying signs of ageing.”

    What does collagen decline look like on the outside?

    Skin: Less bounce, more sag

    Collagen gives skin its structure and firmness. As levels drop, you start noticing:

    • Fine lines and wrinkles (the classics)
    • Loss of elasticity and plumpness
    • Dryness, dullness and slower wound healing

    “The collagen in our skin reflects a delicate equilibrium between synthesis and degradation,” Mercedes Abarquero Cerezo, pharmacist and head of scientific projects at L’Oréal Dermatological Beauty Spain, says. “As we age, the cells responsible for collagen production slow down. At the same time, a host of external and internal factors—from sun exposure and diet to stress and hormonal shifts, particularly during menopause—can speed up its breakdown.”

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  • Male Leopard Seals Sing Songs Similar To Nursery Rhymes To Woo Mates, Study Shows

    Male Leopard Seals Sing Songs Similar To Nursery Rhymes To Woo Mates, Study Shows

    Leopard seal opens it mouth for a photograph while laying out on the ice. (Photo by Tarpan on Shutterstock)

    In A Nutshell

    • Male leopard seals sing underwater during mating season, producing complex sequences using five distinct call types.
    • Their songs show statistical patterns that are more structured than random noise but more random than nursery rhymes.
    • Compared to other animals, the seals’ songs are less predictable than humpback whale songs but more organized than dolphin and monkey vocalizations.
    • The vocal sequences are consistent across days, suggesting the songs may help identify individual seals across vast Antarctic distances.

    SYDNEY — Beneath Antarctic ice, one of the ocean’s most fearsome predators is belting out underwater ballads that follow recognizable patterns, and scientists say they carry a statistical structure not unlike a nursery rhyme. Male leopard seals, solitary marine mammals known for hunting penguins, spend hours each day during breeding season performing elaborate vocal sequences that show more order than randomness.

    New research published in Scientific Reports shows that these apex predators create underwater vocalizations with statistical patterns that are comparable to nursery rhymes in their predictability, but with more randomness. Scientists analyzed songs from 26 male leopard seals in Eastern Antarctica and found that their vocalizations are more structured than random noise, but less constrained than many forms of human music.

    As the University of New South Wales researchers write, “The estimated information entropy of the leopard seal songs is comparable to nursery rhymes but unsurprisingly, lower than contemporary, classical and baroque music.”

    A leopard seal in the wild resting on an ice floe in Antarctica.A leopard seal in the wild resting on an ice floe in Antarctica.
    A leopard seal in the wild resting on an ice floe in Antarctica. (Photo by Michelle Sole on Shutterstock)

    How Do Leopard Seals Create Their Underwater Songs?

    Leopard seals perform their songs using five distinct call types: high double trills, medium single trills, low descending trills, low double trills, and a hoot with a low single trill. Males arrange these into long underwater sequences, surfacing briefly to breathe before diving back down to continue their vocal routines.

    “They’re like the songbirds of the Southern Ocean,” study co-author Tracey Rogers says in a statement. “During the breeding season, if you drop a hydrophone into the water anywhere in the region, you’ll hear them singing.”

    To assess how structured these sequences are, the researchers used a mathematical tool called information entropy. In simple terms, a completely random sequence has high entropy, while a more predictable sequence has lower entropy.

    Recordings from 1992 to 1998 revealed that leopard seal songs aren’t just random collections of sounds. Knowing one call made it statistically more likely to predict the next, though the songs were still more random than nursery rhymes.

    How Do Leopard Seal Songs Compare to Other Animal Communication?

    Compared to other animals, leopard seal vocalizations occupy a middle ground of complexity. The study found that their songs have less predictable temporal structure than those of humpback whales and bottlenose dolphins, including dolphin whistle sequences. Entropy estimates for squirrel monkeys were similar to those of leopard seals, suggesting comparable levels of vocal complexity, though the paper does not state a clear hierarchy between them. Importantly, all of these animal vocalizations were far more structured than random sequences, indicating meaningful patterning in how sounds are arranged.

    Compared to human music, leopard seal songs were more predictable than compositions by the Beatles and far more so than classical works by composers like Bach or Mozart, which exhibit much higher variation and entropy. The seals’ vocalizations were statistically comparable to simple nursery rhymes, though slightly more random.

    This distribution of vocal complexity appears to reflect the biological needs of each species. For leopard seals, which remain solitary and widely dispersed during mating season, structured songs may help individuals identify each other across long distances.

    “The greater structure in their songs helps ensure that distant listeners can accurately receive the message and identify who is singing,” explains lead author Lucinda Chambers. “It’s like they’re saying, ‘I’m the biggest and the strongest, look how long and how loud I can sing’.”

    Why Do Leopard Seals Use Predictable Song Patterns?

    The study found that individual males repeat signature vocal patterns with strong consistency. According to the paper, “Individual leopard seals were observed to retain their particular sequences over three days which suggests that the sequences are stable and could encode information about the singer’s identity.”

    Singing also demands significant energy. “Larger males maintain a more consistent call rate that does not vary throughout the breeding season,” the paper notes, while smaller seals often reduce their singing over time, likely due to fatigue.

    The researchers conclude: “The greater structure of the leopard seal’s song improves the ability of distant listeners to accurately receive signals and identify singers, which is essential for this widely dispersed species”.

    This study is part of a growing effort to understand how animals encode and transmit information. Rather than focusing on what the sounds mean, researchers used statistical methods to study how the sequences are built.

    While leopard seal songs aren’t as tightly structured as human compositions or whale songs, they’re clearly not random. Their structure likely evolved to help communicate identity or fitness across the vast icy expanses of Antarctica, suggesting even solitary predators rely on remarkably intricate signals.


    Paper Summary

    Methodology

    Researchers recorded leopard seal vocalizations in the Davis Sea, Eastern Antarctica, between 1992-1998 during the breeding season (November-January). They analyzed songs from 26 individual male seals, converting the acoustic sequences into symbolic codes using five distinct call types. The team applied information entropy analysis using three different mathematical models: independent and identically distributed (i.i.d.), first-order Markov models, and sliding window match length (SWML) estimation. They compared the entropy values to other animal communications and human music to determine relative complexity and predictability.

    Results

    Leopard seal songs showed entropy estimates ranging from 0.63-2.38 bits, with values comparable to nursery rhymes but lower than classical music. All songs demonstrated more sequential structure than random sequences, with knowing previous calls helping predict subsequent ones. However, 21 of 26 seals showed patterns too complex for simple first-order Markov models to fully capture. The songs were more predictable than contemporary classical music but less predictable than humpback whale songs, suggesting intermediate complexity in animal communication systems.

    Limitations

    The study used recordings from a single geographic region and time period (1990s), limiting generalizability across leopard seal populations. Sample sizes for some analyses were constrained by the need for sufficient sequence length. The SWML entropy estimator contained positive bias that couldn’t be analytically corrected. Comparisons with other species were limited by different methodological approaches and sample sizes in previous studies. The biological meaning of the statistical patterns remains unknown.

    Funding and Disclosures

    The authors declared no competing interests and stated no financial conflicts that could influence the research objectivity. No specific funding sources were mentioned in the paper. The study was conducted by researchers from the University of New South Wales Sydney, Australia, and the University of Massachusetts Dartmouth, USA.

    Publication Information

    “Leopard seal song patterns have similar predictability to nursery rhymes” by Lucinda E. H. Chambers, John R. Buck, and Tracey L. Rogers was published in Scientific Reports (2025), volume 15, article number 26099. The paper is available under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. DOI: https://doi.org/10.1038/s41598-025-11008-8.

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  • To infinity and beyond! Supercharging stem cells in space

    To infinity and beyond! Supercharging stem cells in space

    Earlier this week, the Kennedy Space Center launched the 11th SpaceX crew to the International Space Station’s (ISS) orbital laboratory, seeking to advance regenerative medicine.

    The four-astronaut crew will produce stem cells in a microgravity environment, study blood vessels in engineered liver tissue, and prepare in-orbit data storage and analytics for scalable expansion in manufacturing capabilities. NASA astronauts Zena Cardman and Mike Fincke will respectively serve as mission commander and pilot, while specialists Kimiya Yui (Japan Aerospace Exploration Agency) and Oleg Platonov (Roscosmos) will fill out the crew.

    Two sponsored investigations will focus on the production and differentiation of stem cells within a microgravity environment, which is thought to hasten the aging process and quicken cell determination. BioProcess Insider reported on another mission aboard the ISS in June 2024, where microgravity was used to induce and maintain pluripotency in cells.

    Researchers from Cedars-Sinai Medical Center and the University of Colorado aim to determine whether stem cells can be produced faster and in large quantities for application to therapeutics for heart and neurodegenerative diseases.

    The Wake Forest Institute for Regenerative Medicine will lead the groundwork for growing transplant organs in space, specifically studying engineered liver tissue that contains blood vessels. The project was initially part of NASA’s Vascular Tissue Challenge, a $500,000 initiative concluded in 2021 where teams worked to create metabolically functioning human vascularized organ tissue. The research seeks to grow single human cells into fully vascularized organs that can be transplanted into astronauts that need them during long-duration missions.

    Related:The value of analytical ultracentrifugation in characterizing lipid nanoparticles

    Crew members will also participate in a pioneering DNA experiment that high school students pitched as part of an ISS initiative to empower young people to get involved with space-station research. New York high schoolers Isabelle Chuang and Julia Gross proposed the experimental design of inciting bacteriophages to attack and kill viruses in space as a means of combatting antibiotic resistance.

    Finally, the crew will work to increase orbital data storage with commercial collaborator Red Hat. The partners will leverage the Device Edge platform for real-time analytics of experiments aboard the ISS, important for upscaling manufacturing capabilities in orbiting labs.

    BioProcess Insider recently delved into space biotech company Varda, which is using the benefits of microgravity and low-orbit laboratories to produce improved uniformity in crystal morphology for drug formulations.

    Related:From mentees to market leaders: MBI Spark program graduates three promising companies

    Although space may be the final frontier, it offers limitless possibilities for biotechnology innovations beyond Earth’s boundaries.


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  • Timberwolves Sign Forward Enrique Freeman to Two-Way Contract – NBA

    Timberwolves Sign Forward Enrique Freeman to Two-Way Contract – NBA

    1. Timberwolves Sign Forward Enrique Freeman to Two-Way Contract  NBA
    2. Just two days ago, the Pacers withdrew their …  HoopsHype
    3. Enrique Freeman Excited to be in NBA Free Agency, First Camp a Success  rg.org
    4. Timberwolves’ latest moves make Tristen Newton’s future unclear  Dunking with Wolves
    5. Former Pacers Big Reacts to Surprisingly Getting Cut After NBA Finals Run  Sports Illustrated

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  • Robert Wilson dead: Visionary playwright, director, visual artist dies

    Robert Wilson dead: Visionary playwright, director, visual artist dies

    Robert Wilson, a leader in avant-garde theater who collaborated with Philip Glass, David Byrne and Lady Gaga over his six-decade career, has died. He was 83.

    The “Einstein on the Beach” director died Thursday at his home in Water Mill, N.Y., after a “brief but acute illness,” according to his website.

    “While facing his diagnosis with clear eyes and determination, he still felt compelled to keep working and creating right up until the very end,” the statement reads. “His works for the stage, on paper, sculptures and video portraits, as well as the Watermill Center, will endure as Robert Wilson’s artistic legacy.”

    Wilson was born on Oct. 4, 1941, in Waco, Texas, to a conservative Southern Baptist family. He struggled with a speech impediment and learning disabilities as a child but was aided by his ballet teacher, Byrd Hoffman.

    “She heard me stutter, and she told me, ‘You should take more time to speak. You should speak slowly,’ ” he told the Observer in 2015. “She said one word over a long period of time. She said go home and try it. I did. Within six weeks, I had overcome the stuttering.”

    In 1968, Wilson opened an experimental theater workshop named after his mentor: the Byrd Hoffman School of Byrds. He created the Byrd Hoffman Water Mill Foundation in 1969, under which he established the Watermill Center in 1992.

    In his early 20s, Wilson moved to Brooklyn, N.Y., where he studied interior design and architecture at the Pratt Institute. Later, he joined the recreation department of Goldwater Memorial Hospital, where he brought dance to catatonic polio patients with iron lungs.

    “Because the patients were largely paralyzed, the work he was doing with them was more mental than physical,” wrote his former colleague Robyn Brentano in Frieze. “With his unconventional frankness and tenderness, he drew out people’s hidden qualities.”

    Wilson started teaching movement classes in Summit, N.J., while he wrote his early plays. One day in 1968, he witnessed a white police officer about to strike a deaf, mute Black boy, Raymond Andrews, while walking down the street. Wilson came to Andrews’ defense, appeared in court on his behalf and eventually adopted him. Together, Andrews and Wilson created “Deafman Glance,” a seven-hour “silent opera,” which premiered in 1970 in Iowa City, Iowa.

    “The world of a deaf child opened up to us like a wordless mouth. For more than four hours, we went to inhabit this universe where, in the absence of words, of sounds, 60 people had no words except to move,” wrote French Surrealist Louis Aragon after the 1971 Paris premiere. “I never saw anything more beautiful in the world since I was born. Never, never has any play come anywhere near this one, because it is at once life awake and the life of closed eyes, the confusion between everyday life and the life of each night, reality mingles with dream, all that’s inexplicable in the life of deaf man.”

    In 1973, Glass attended a showing of Wilson’s “The Life and Times of Joseph Stalin,” which ran for 12 hours from 7 a.m. to 7 p.m. The two artists, united by their interest in experimenting with time and space in theater, soon teamed up to create “Einstein on the Beach,” which premiered in 1976 in Avignon, France.

    “We worked first with the time — four hours — and how we were going to divide it up,” Glass told the Guardian in 2012. “I discovered that Bob thinks with a pencil and paper; everything emerged as drawings. I composed music to these, and then Bob began staging it.”

    Times classical music critic Mark Swed called “Einstein” “easily the most important opera of the last half century,” even though “nothing about what composer Philip Glass and director Robert Wilson put onstage was opera.” Indeed, “Einstein” has become a cult classic despite the fact it has no Einstein, no beach and no narrative.

    Wilson and Glass partnered again to create “the CIVIL warS: a tree is best measured when it is down,” which also featured music from Talking Heads frontman Byrne, for the 1984 Summer Olympics in Los Angeles. The project, meant to span 12 hours, was ultimately never completed due to funding problems. In 1995, Wilson shared his concerns about arts funding in the U.S. with The Times.

    “The government should assume leadership,” Wilson told Times contributor Jan Breslauer. “By giving the leadership to the private sector in a capitalistic society, we’re going to measure the value of art by how many products we can sell. We need to have a cultural policy [instead]. There has to be a balance between government and the private sector.

    “One of the few things that will remain of this time is what artists are doing,” Wilson says. “They are the journal and the diary of our time.”

    In addition to his stage work, Wilson created drawings, sculptures, furniture and installations, which he showed at the Paula Cooper Gallery in New York beginning in 1975. In 2004, Wilson produced a series of video portraits featuring Brad Pitt, Winona Ryder, Renée Fleming and Alan Cumming. He would return to the medium again in 2013 with Lady Gaga as his subject.

    His work on the installation “Memory/Loss” earned him a Golden Lion for sculpture at the Venice Biennale in 1993.

    One of Wilson’s last projects was an installation commissioned by Salone del Mobile in April Centering on Michelangelo’s Rondanini Pietà at Milan’s Castello Sforzesco, the project explored the Virgin Mary’s pain following Christ’s death with a combination of music, light and sculpture.

    “I’m creating my own vision of the artist’s unfinished masterpiece, torn between a feeling of reverential awe and profound admiration,” he told Wallpaper.

    Wilson is survived by Andrews; his sister, Suzanne; and his niece, Lori Lambert.

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  • ‘Sex and the City’ sequel ‘And Just Like That…’ to end after 3 seasons

    ‘Sex and the City’ sequel ‘And Just Like That…’ to end after 3 seasons

    And just like that, a universe of fun, friendship and fashion is coming to an end.

    Michael Patrick King, showrunner of the “Sex and the City” sequel “And Just Like That …,” announced on Instagram that the series will end after the third season concludes. Fans have a two-part finale to savor later this month.

    “It’s with great gratitude we thank all the viewers who have let these characters into their homes and their hearts over these many years,” he wrote.

    King said he decided to wrap things up while writing the season’s final episode. He then split the finale into two episodes. The last episode will drop Aug. 14.

    In a long, heartfelt Instagram post of her own, Sarah Jessica Parker, who played the iconic Carrie Bradshaw character in both series, called the sequel “all joy, adventure, the greatest kind of hard work alongside the most extraordinary talent.” She included a montage of Carrie’s fashion and moments.

    Parker added: “I am better for every single day I spent with you. It will be forever before I forget. The whole thing. Thank you all. I love you so.”

    Parker, Kristin Davis and Cynthia Nixon returned for the sequel. Largely absent was Kim Cattrall and her Samantha Jones, though Cattrall did make a brief, uncredited cameo in the Season 2 finale. Samantha’s absence was explained as a move to London. Reports of pay and personal disputes bubbled over behind the scenes.

    The original series ran from 1998 to 2004, taking pop culture by storm with the style and drama of the 30-something friends in New York City. They shopped. They brunched. They dated, leaning on each other as Parker’s Carrie, a writer, chronicled it all.

    The sequel picks up their lives in their mid-50s, to mixed reviews. Carrie became a widow. Nixon’s Miranda Hobbes came out as queer. Davis’ Charlotte York Goldenblatt copes with husband Harry’s prostate cancer diagnosis.

    Fashion remains ever-present, including all those iconic heels still clacking through New York’s brownstone-lined streets.

    In her farewell post, Parker wrote of her stylish Carrie that she, “Changed homes, time zones, boyfriends, her mind, her shoes, her hair, but never her love and devotion to New York City.” She called Carrie “my professional heartbeat for 27 years.”


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