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  • Long-Term Proton Pump Inhibitor Use and the Risk of Kidney Disease, Dementia, and Fractures: A Systematic Review – Cureus

    1. Long-Term Proton Pump Inhibitor Use and the Risk of Kidney Disease, Dementia, and Fractures: A Systematic Review  Cureus
    2. A Systematic Review of the Adverse Effects of Long-Term Proton Pump Inhibitor Use on the Gastrointestinal System in the Adult Population  Cureus
    3. Warning over commonly prescribed drug millions take every day  Wales Online
    4. Acid reflux drug taken by millions could HARM your digestion, warns top pharmacist  Daily Mail
    5. Pharmacist shares hidden’ dangers of pill taken by millions in UK  The Mirror

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  • Space Machines completes in-house propulsion engine

    Space Machines completes in-house propulsion engine

    Space Machines Company has announced the completion of a proprietary propulsion engine. The Scintilla engine has achieved extended burn durations of 65 seconds with over 1,200 seconds of total testing time and 40 restarts and counting, representing a critical advancement in the company’s Rapid Response Vehicle – Optimus Viper, designed for rapid orbital manoeuvring and space domain awareness missions.

    Developed entirely in-house by SMC’s propulsion team, Scintilla delivers 50 Newtons of thrust while maintaining 92% efficiency, exceeding the company’s initial 90% efficiency target with a clear pathway to near-100% efficiency in future iterations. The metal 3D-printed engine represents a new approach to satellite propulsion, prioritising reliability, scalability, and rapid iteration capabilities.

    “We’ve achieved faster progress than even our most optimistic schedules predicted,” said Rajat Kulshrestha, Co-Founder and CEO of SMC. “The engine has reached steady-state conditions and demonstrated the ability to run for extended periods – a critical requirement for our satellite operations. We can now run this engine for minutes, limited only by total propellant supply from our tanks.”

    Unlike traditional satellite manufacturers who typically outsource propulsion systems, Space Machines Company has invested in complete vertical integration for this mission-critical technology. The decision reflects the central role propulsion plays in the company’s satellite capabilities, with the Optimus Viper platform designed around extensive orbital manoeuvring requirements.

    “Propulsion is absolutely core to what Space Machines needs to do,” explained Ian Partis, Vice President, Engineering and Mission Operations at SMC. “The better the propulsion system and the more delta-v available, the greater range of orbits we can access and the faster we can get there. This is so fundamental to our mission that the satellite is essentially a propulsion system with a payload on top.”

    The completed Scintilla engine progressed through preliminary design, development testing, and critical design review phases. Final accomplishments include:

    • Extended burn capability: 65-second continuous operation with demonstrated ability for longer durations
    • High efficiency: 92% performance with an engineering pathway to 99%+ efficiency
    • Scalable design: Architecture capable of 10 x  thrust output with minimal modifications
    • Restart capability: Multiple ignition cycles for complex orbital manoeuvres
    • Robust operational envelope: Tested across varying conditions to ensure reliable performance

    The propulsion system’s design allows for significant performance scaling, with the ability to increase thrust from the current 50 Newtons to 100-500 Newtons through relatively minor modifications.

    The successful completion of Scintilla demonstrates the effectiveness of SMC’s “build-to-learn, learn-to-build” development philosophy. The team discovered failure modes through rapid iteration, maintained multiple backup systems, and ensured continuous learning capabilities through co-located testing and manufacturing facilities.

    “Having everything vertically integrated means we can respond immediately to design changes without external contractor delays,” noted Rajat Kulshrestha. “When the team identified an issue during testing, they were able to diagnose it within 10 minutes and implement solutions immediately. This kind of responsiveness is impossible when working with external suppliers.”

    With the engine development complete, Space Machines Company is now proceeding to full subsystem integration, incorporating flight-grade valves and propellant management systems. The Scintilla engine will power the company’s Rapid Response Vehicle – Optimus Viper, designed for space domain awareness and rapid orbital manoeuvring missions.

    “This achievement demonstrates that small, focused teams can deliver world-class propulsion systems on accelerated timelines,” said Ian Partis. “The propulsion-centric design of our Optimus Viper satellite represents a fundamentally different approach to space missions, where manoeuvrability and rapid response are paramount.”


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  • Orlando Bloom shares aspirations for ‘Pirates of the Caribbean’ reboot

    Orlando Bloom shares aspirations for ‘Pirates of the Caribbean’ reboot



    Orlando Bloom shares plans for ‘Pirates of the Caribbean’ reboot

    Pirates of the Caribbean, with Disney preparing to breathe new life into the franchise, Orlando Bloom is making it clear that he wants to reunite with his old crew.

    The actor, who played Will Turner in four of the five films, recently told fans at Fan Expo Chicago that the best way forward for the series would be to bring the original cast back together, including Johnny Depp and Keira Knightley. 

    “Everything is in the writing, right? Everything is on the page, and I think there’s definitely, I’m sure there’s a way to create something,” Bloom said. 

    “I would personally love to see everybody back. I think the way to win on that one is to get everybody back. If they can, and if everybody wanted to go back.”

    Bloom and Knightley both appeared in the first three films, The Curse of the Black Pearl, Dead Man’s Chest and At World’s End, before returning alongside Depp for Dead Men Tell No Tales in 2017. 

    The only installment they skipped was 2011’s On Stranger Tides

    For Bloom, a potential return would only make sense if the story was strong enough. 

    “My thing is, if the script was great and, ideally it was everybody, it’d be kind of like in for a penny, in for a pound, you know,” he added.

    Producer Jerry Bruckheimer confirmed last year that writer Jeff Nathanson is working on a reboot, while a separate spin-off project, written by Christina Hodson and once attached to Margot Robbie, is still in development. 

    Bloom admitted the challenge is figuring out the right approach. 

    “What they’re thinking…is how to do it,” he said. “Do you bring in a female leading character that replicates Jack in some way? I don’t know. The jury is out on how to do it again.”

    Bruckheimer has also said he believes Depp could return as Captain Jack Sparrow if the script hits the right note. Knightley, however, has been vocal about stepping away from large franchises. 

    Reflecting on her experience with Pirates, she shared last year, “The hours are insane. It’s years of your life, you have no control over where you’re filming, how long you’re filming, what you’re filming.”

    For now, fans will have to wait and see whether Bloom’s wish for a full cast reunion can become reality, or whether Disney takes the franchise in an entirely new direction.

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  • Thailand requires banks to cap most online transfers at $1,500 daily to thwart scammers

    Thailand requires banks to cap most online transfers at $1,500 daily to thwart scammers

    BANGKOK — Banks in Thailand are now required to set a daily limit of 50,000 baht ($1,537) on many online transfers to lessen financial fraud, particularly those involving customers judged vulnerable such as children and older people.

    The rule announced Tuesday by the Bank of Thailand is meant to help combat the huge criminal industry of online scams, which makes billions of dollars annually and is especially active in Southeast Asia. In many countries there is increasing pressure on banks to play a more active role in safeguarding the assets of customers targeted by scammers.

    The new measure aims to curb financial fraud by preventing criminals from receiving and transferring a large amount of money at one time, and enabling timely freezing of illicit funds in order to increase the chances that victims will be able to recover at least some of their money, according to Daranee Saeju, the bank’s assistant governor for Payment Systems Policy and Financial Consumer Protection.

    The daily transfer limit will be applied to transfers in three different tiers: under 50,000 baht ($1,537), under 200,000 baht ($6,147) and above 200,000 baht ($6,147), depending on each customer’s risk profile and the banks’ assessment under know-your-customer, or KYC, rules.

    Customers with established records of responsibility can continue transferring at their usual levels.

    This measure will be implemented for new mobile banking and internet banking customers by the end of this month and for existing customers by the end of this year.

    Thailand has around 12 million mobile banking users, according to a report Wednesday in the Bangkok Post newspaper. It said previous central bank safeguards capped mobile banking transfers at 50,000 baht ($1,537) per transaction — with facial recognition required — and 200,000 baht ($6,147) per day in total.

    In June alone this year, 24,500 scam cases related to money transfers were reported to the authorities, causing total losses of 2.8 billion baht ($86.1 million) — an average of 114,000 baht ($3,504) per case. The largest single fraudulent transfer amounted to 4.9 million baht ($150,591), the Post reported, citing the central bank.

    On average, scammers needed only three minutes to siphon off half of the stolen funds, while victims typically took 19–25 hours to report the crime, the newspaper reported.

    For the first six months of this year, children under 15 were involved in 78,468 financial scam cases, while victims over 65 years of age accounted for 416,453 cases, it said.

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  • Coco Gauff splits with coach as US Open looms on horizon

    Coco Gauff splits with coach as US Open looms on horizon

    Two-time Grand Slam champion Coco Gauff has parted ways with coach Matt Daly just days before the US Open tennis begins.

    The world No. 3 split with Daly, a grip expert who she brought on board late last year, replacing him with biomechanics specialist Gavin MacMilan, according to various reports.

    MacMilan was seen practising with Gauff – who has yet to address the change herself – on Wednesday (20 August) at the US Open in New York. Her long-time coach Jean-Christophe Faurel stays with the team.

    MacMilan is widely credited in the industry for rectifying Aryna Sabalenka’s serve. Sabalenka is currently the world’s top-ranked player.

    Gauff has had double fault issues as of late and is counting on MacMilan to work his magic the way he did with Sabalenka.

    At last week’s Cincinnati Open, a WTA 1000 tournament, Gauff was eliminated in the quarter-finals by Jasmine Paolini.

    The main draw of the US Open starts on Sunday.

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  • Baidu Sales Slide Most Since 2022 in Fierce China AI Contest

    Baidu Sales Slide Most Since 2022 in Fierce China AI Contest

    A Baidu AI Cloud advertisement featuring humanoid robots at the Hongqiao International Airport in Shanghai.

    Baidu Inc.’s quarterly revenue fell its most in about three years, hurt by an economic downturn that’s capping its ability to fight bigger rivals in AI and make inroads in newer areas.

    The Ernie chatbot creator’s sales in the June quarter fell 4% to 32.7 billion yuan ($4.6 billion), weighed down by a slowdown in its core internet search operations. Net income rose 33%, versus projections for a decline, helped by a boost from long-term investments. The company’s shares slid as much as 3% in Hong Kong Thursday.

    Most Read from Bloomberg

    China’s internet search leader is betting big on generative AI to drive future growth, but it faces mounting pressure from open-sourced models like DeepSeek as well as a wave of AI-native apps encroaching on its turf. The company will continue to invest in artificial intelligence even as margins and revenue come under pressure in the near term, Chief Financial Officer Henry He said.

    That’s while its mainstay search business loses ground to social-video platforms like Xiaohongshu and TikTok’s Chinese twin Douyin. Online advertising revenue declined 15%. But non-marketing revenue grew a better-than-expected 34%, aided by demand for its cloud unit.

    “Since the AI search monetization is still in very early stages and has yet to scale, our revenue and margins are under considerable pressure in the near-term with Q3 expected to be especially challenging,” He said. “We see potential for margin improvement as our core advertising business recovers and stabilizes.”

    Baidu’s Shares Drop After Revenue Slowdown: Street Wrap

    Baidu is counting on Ernie to underpin an AI ecosystem and drive demand for its cloud division, whose sales have grown by double-digits in recent quarters.

    It’s also accelerating an overseas push by its Apollo Go robotaxi service, through partnerships with Uber Technologies Inc. and Lyft Inc. Baidu’s driverless rides in the June quarter more than doubled to 2.2 million, with cumulative rides passing 14 million in August, it said.

    Baidu plans to take its fleet of self-driving robotaxis — common in Beijing, Guangzhou and Wuhan — to Singapore and Malaysia as early as this year, Bloomberg reported. The company is now running trials in Hong Kong.

    But in China’s increasingly crowded AI arena, Baidu faces rivals Alibaba Group Holding Ltd. and Tencent Holdings Ltd. — both with far more firepower and larger global footprints — as well as nimble upstarts. Baidu’s stock price is up around 6% this year, trailing both of the bigger internet leaders.

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  • ‘We rely on how Leo feels, and it wasn’t the best’ – Inter Miami assistant coach Javier Morales explains why Lionel Messi was ruled out vs. Tigres

    ‘We rely on how Leo feels, and it wasn’t the best’ – Inter Miami assistant coach Javier Morales explains why Lionel Messi was ruled out vs. Tigres

    • The Herons advanced with a Luis Suárez brace.
    • Morales gave no further details on Messi’s fitness
    • Jordi Alba also picked up an injury
    Get the MLS Season Pass today!

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  • Tencent’s ‘Valorant’ Tops iPhone Chart With $1 Million Debut

    Tencent’s ‘Valorant’ Tops iPhone Chart With $1 Million Debut

    Valorant

    Tencent Holdings Ltd.’s made a strong debut on mobile this week, earning $1 million in gross player spending on iPhones on its first day out in China.

    The colorful shooting game, first released on PC in 2020, is one of Tencent’s big mobile launches this year, closely watched as an indicator of the company’s strategy to sustain what it calls evergreen franchises. It had roughly 170,000 downloads on day one, about as many as Tencent’s a year earlier, and remains No.1 in downloads among all iPhone apps, according to Appfigures data.

    Most Read from Bloomberg

    Co-developed by Tencent’s Riot Games and Lightspeed Studios, is available only in China so far, with no clear launch date for global markets. The game is free to play, with in-app purchases and character cosmetics making up the revenue. That’s the same monetization method as , though that game earned roughly five times as much on its release, whereas is currently sixth on the charts for highest-earning games, Appfigures said.

    Tencent is a global leader in shooting games, having previously adapted to smartphones. Its executives have said they aim to offer a diverse range of options to gamers, though it remains an open question whether these games will cannibalize each other. On mobile alone, Tencent runs shooting franchises including , , and its in-house and .

    The company said last week that attracted more than 70 million pre-registrations across all platforms. Appfigures does not track spending and downloads on Android, which has several app stores in China.

    The original PC game is known for its unforgiving speed, where players can be eliminated very quickly. It remains to be seen whether such gameplay will be as much of a hit on smartphones, where touch controls make precision more difficult. Last year, one of Tencent’s studios tested , a mobile game with similar gameplay to , but the title was shut down soon after launch.

    –With assistance from Zheping Huang.

    Most Read from Bloomberg Businessweek

    ©2025 Bloomberg L.P.

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  • The Effect of Women’s Empowerment on Unmet Needs for Family Planning in Tanzania: Analysis of 2022 Tanzania Demographic and Health Survey (TDHS) | BMC Public Health

    The Effect of Women’s Empowerment on Unmet Needs for Family Planning in Tanzania: Analysis of 2022 Tanzania Demographic and Health Survey (TDHS) | BMC Public Health

    This research employed a cross-sectional design, using secondary data from the most recent 2022 Tanzania Demographic Health Survey (TDHS) dataset. The Demographic Health Survey (DHS) is nationally representative carried out every five years in over 85 low- and middle-income countries globally [21]. Participants in the survey are selected through a multistage sampling process. The methodology employed in the 2022 TDHS is present at https://www.dhsprogram.com/publications/publication-fr382-dhs-final-reports.cfm?cssearch=1811439_1[21].

    A total of 15,254 eligible women age 15–49 years from 15,705 households were successfully interviewed. The survey had a response rate of 97%. For the purpose of this study, only women who were married or cohabiting were included. This was because the Survey-based Women Empowerment (SWPER) Global required primarily women who were cohabitting or married to create the empowerment scale [22]. This brought the final sample size for the study to 9000 women age 15–49 years.

    The detail description of the methodology used for the 2022 TDHS is freely available in the DHS website (https://www.dhsprogram.com/publications/publication-FR382-DHS-Final-Reports.cfm) [21]. Figure 1 shows a summary of the sampling process in a flow chart.

    Fig. 1

    Sampling process used in this study

    Data Collection and Data Collection Instrument

    This study’s data is obtained from the responses in the woman’s questionnaire. The Woman’s questionnaire or also called the individual questionnaire collected data on maternal and child health issues, including but not limited to background characteristics (age, marital status, education, exposure to media, etc.), child birth and mortality history, family planning use and knoweldge, etc.

    The SWPER (Survey-based Women’s emPowERment) Global Index is created using 14 questions from the woman’s individual questionnaire in the Demographic and Health Surveys (DHS) [22, 23]. These questions are grouped into three domains of women’s empowerment:

    1. (1)

      Social Independence: Access to information (frequency of reading newspapers or magazines), Educational attainment, Age at marriage, Age at first child, Differences in age and education between the woman and her cohabiting partner.

    2. (2)

      Decision-Making: Who makes decisions in the household on large purchases, Who makes decisions about the woman’s health care, Who makes decisions about visits to family or relatives, and Whether the woman worked in the previous year.

    3. (3)

      Attitudes to Violence: Woman’s opinion on whether a husband is justified in beating his wife in specific situations (e.g., leaving the house without telling the husband, neglecting the children).

    These variables are combined using principal component analysis (PCA) to create the SWPER Global Index.

    Study variables

    Outcome variable

    The focus of this study is on the unmet needs for FP among women age 15–49 years in Tanzania. Unmet needs for family planning is described as a fecund woman, who are sexually active and wishes to either space their birth or limit the number of children but are not using any modern contraceptive method [24]. These unmet needs are categorized into two distinct measures:

    Unmet Need for Spacing: This refers to fertile women who wish to space their births but are not currently using any modern contraceptive methods.

    Unmet Need for Limiting Births: This pertains to fertile women who do not desire any more children but are not using any modern contraceptive methods.

    The primary outcome variable for this study is the unmet need for FP, (coded as 0 = no unmet for FP and 1 = unmet for FP), which includes both the unmet needs for spacing or need for limiting births. This outcome variable is not directly listed in the DHS dataset. It was obtained by recoding of data on family planning use among the women. The recoding process is available at https://github.com/DHSProgram/DHS-Indicators-Stata/tree/master/Chap07_FP.

    Explanatory variables

    The primary explanatory variable in this study is women’s empowerment, measured using the SWPER Global index. This index is a meticulously crafted measure of women’s empowerment, derived from the Demographic and Health Surveys (DHS) data for 62 low- and middle-income countries [20, 23]. The SWPER Global index encompasses three key domains:

    Attitude Towards Violence: This domain evaluates a woman’s opinion on whether a husband is justified in beating his wife in specific situations.

    Social Independence: This domain assesses a woman’s access to information, attainment of a desirable educational level, age at marriage and first childbirth, and the differences in age and education between the woman and her cohabiting partner.

    Decision Making: This domain measures who makes decisions in the household and whether the woman is employed.

    Women are categorized into low, medium, and high empowerment levels based on the cutoff points defined in the SWPER Global methodology. The comprehensive design of this index is detailed by Ewerling and colleagues. The STATA do-file for calculating the SWPER index is available at https://goo.gl/isGonn [22].

    The study also included covariates that is used to control for the primary explanatory variables. These covariates are obtained are significant variables associated with unmet needs for FP in previous studies [4, 25,26,27,28,29,30]. These variables were categorized into individual level variables and community level factors. Some of the community level variables we aggregated individual responses within each cluster, or “community,” and used the average response for categorization [31].

    Community-level variables were generated by aggregating individual responses within each primary sampling unit (PSU), which served as a proxy for “community”. For continuous variables such as educational attainment or wealth index, we calculated the mean or proportion within each cluster. We then created binary indicators for each community-level variable using the following rule:

    Educational attainment (community level): The average number of years of education among women in the cluster was calculated. Women living in clusters above the national mean were coded as “high education community” and those below as “low education community”.

    Wealth index (community level): Using the DHS wealth quintile scale (1 = poorest to 5 = richest), we computed the average wealth index per cluster. Communities with a mean index ≥ 3 (middle or above) were classified as “high wealth”; <3 were “low wealth”.

    Knowledge of family planning (FP): Proportion of women in a cluster who knew at least one modern contraceptive method. Clusters with ≥ 50% of women reporting FP knowledge were classified as “high knowledge”.

    Exposure to FP messages: Defined by the proportion of women in the cluster who reported exposure to family planning messages via radio, newspapers, or any media. Communities with ≥ 50% were labeled “high exposure”.

    All thresholds (e.g., national mean, ≥ 50% cut-off) were selected based on literature precedence and practical distributional cut-points in DHS-based studies [31].

    For instance, suppose in one cluster, the average years of education is 8 years. If a woman’s education level is below 8 years, she is coded as part of a “low-education” community. If her education level is 8 years or higher, she is coded as part of a “high-education” community. Again, let’s say the average wealth index in a community is 2.5 on a scale of 1 to 5, where a lower score indicates lower poverty. If a woman’s wealth index is 2.6 or higher, she is in a “high wealth” community. If her index is below 2.5 or lower, she falls into a “low-wealth” community.

    Table 1 shows each of the study variables and how they are coding.

    Conceptual framework and assumptions

    To guide our model specification and clarify hypothesized relationships, we developed a conceptual model (Fig. 2). This figure represents our theoretical assumptions regarding the directionality and potential confounding or mediating relationships among variables influencing unmet need for family planning.

    Fig. 2
    figure 2

    Conceptual framework for study

    Data analysis

    The data for this study was downloaded in STATA statistical analysis format and the data analysis performed in four stages using STATA version 18 statistical software, with sampling weights from the DHS data applied to adjust for the sampling design.

    In this first stage, we generated a descriptive summary of the variables, including frequency distributions for the sociodemographic characteristics of the women, the unmet needs for FP and SWPER domains.

    In the second stage of the analysis, Pearson’s chi-test was used to test for association between unmet needs for FP and the primary explanatory variables and covariates. Statistical significance was set at p < 0.05.

    In the third stage of the analysis, explanatory variables, which were statistical significantly associated with unmet needs for FP, were included in a regression model to test for multicollinearity using variance inflation factor (VIF). Variables found with vif of 5 or more were excluded from the next stage of the analysis [32].

    In the final stage of the analysis, a mixed-multilevel logistic regression analysis was conducted to identify women empowerment and its association unmet needs for FP. Five regression models were created. The first model (null model) was fitted without explanatory variables to test the random variability in the intercept and show the total variance in the unmet needs for FP among women in different communities. The second model (Model I) fitted women empowerment domains to test the effect of women empowerment on unmet needs for FP. In the third model (Model II), the individual-level factors were also fitted to examine their effect on unmet needs for FP. The Model III examined the effect of community-level factors on unmet needs for FP. The final model (Model IV) examined the combined effect of all statistically significant (p < 0.20) explanatory variables in the preceding models on unmet needs for FP among the women.

    Fixed-effect results were reported as odds ratios with 95% confidence intervals. The Intraclass Correlation Coefficient (ICC) was calculated for each model to quantify the proportion of variation attributable to higher-level clustering and to facilitate comparisons between models.

    In the analysis, the ’svy’ command in STATA was used to allow for adjustments for the cluster-sampling design of the data collection and weights. This was also done to account for selection bias in the study. The “melogit” STATA command was also used for the logistic regression, “estat icc” for the intra-class correlations and “estat ic” for the information criterions (Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC)).

    Missing data

    The data were cleaned by checking and correcting all inconsistencies and discrepancies. Also, missing data were handled by STATA’s default listwise deletion method.

    Ethical consideration

    The data used in this study were secondary and publicly accessible, therefore individual consent was not required by the ICF International Institutional Review Board. This study proceeded with the necessary permissions from the DHS Program, and all data were carefully managed to ensure privacy during the processing and analysis stages of the study.

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  • Japan’s 20-Year Yield Rises to Highest Since 1999 on Fiscal Woes – Bloomberg.com

    1. Japan’s 20-Year Yield Rises to Highest Since 1999 on Fiscal Woes  Bloomberg.com
    2. Japanese Bond Yields Climb To Multi-Year Highs After Weak Auction  Finimize
    3. JGBs inch down amid caution for US inflation data  Business Recorder
    4. Long-Term JGB Yields Little Changed Ahead of Japan CPI, Jackson Hole  MSN
    5. Japan bonds fall after auction; 10-year yield hits 17-year high  TradingView

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