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  • RSV vaccines estimated to be 58% to 83% protective in older adults

    RSV vaccines estimated to be 58% to 83% protective in older adults

    Two new real-world studies estimate the effectiveness of a single dose of a respiratory syncytial virus (RSV) vaccine against hospitalization among older adults at 83% in Denmark and 58% in the United States, respectively.

    83% effectiveness among Danish adults

    The first study, a phase 4 randomized, controlled, open-label trial, finds an 83% effectiveness for the bivalent (two-strain) RSV prefusion F protein-based (RSVpreF; Abrysvo) vaccine in Danish adults aged 60 years and older.

    For the trial, published in the New England Journal of Medicine, a Copenhagen University Hospital–led research team randomly assigned 131,276 participants in a 1:1 ratio to receive RSVpreF vaccine or no vaccine during the 2024-25 respiratory virus season. 

    The researchers analyzed baseline and outcome data from electronic health records and national registries to determine rates of hospitalization for RSV-related respiratory tract disease and, secondarily, hospitalization for RSV lower respiratory tract disease and for all-cause respiratory tract disease from 14 days post-vaccination to May 31, 2025. 

    “Phase 3 trials of RSVpreF vaccines against RSV-related lower respiratory tract disease have shown vaccine efficacy levels of 88.9%, 82.6%, and 83.7% for nonadjuvanted, adjuvanted, and mRNA-based forms, respectively,” the study authors wrote. “However, the trials were not designed or powered to evaluate severe outcomes such as hospitalization.” An adjuvant is an immune-enhancing addition. 

    Study authors included representatives from RSVpreF manufacturer Pfizer, who participated in the trial design and development of the protocol and statistical methods but not in the conduct of the trial or in data collection or analysis. 

    Statistical success criterion met

    During follow-up, 2,236 RSV tests were performed in 2,175 participants (1.7%), including 1,089 participants (1.7%) of RSVpreF recipients and 1,086 (1.7%) in the control group, and 6,660 influenza tests were performed. Of 619 participants hospitalized for any respiratory disease, 22.8% underwent RSV testing—65 of 284 participants (22.9%) in the RSVpreF group and 76 of 335 participants (22.7%) among controls.

    Hospitalization for RSV respiratory tract disease occurred in 3 of 65,642 RSVpreF participants and 18 of 65,634 unvaccinated controls (0.11 events vs 0.66 events per 1,000 participant-years; vaccine effectiveness [VE], 83.3%). This finding met the criterion for statistical success of the vaccine (minimum effectiveness of greater than 20%). 

    Approximately 416,500 to 655,500 of these events could be prevented with the RSVpreF vaccine if the vaccine effectiveness was identical in all populations.

    RSVpreF recipients also had fewer hospitalizations for RSV lower respiratory tract disease than controls (1 vs 12; VE, 91.7%) and for all-cause respiratory tract disease (284 vs 335; VE, 15.2%). At least one serious adverse event (SAE) occurred in 3,010 participants—1,341 in RSVpreF recipients and 1,669 in controls during the 6-week safety surveillance period.

    An SAE considered related to RSVpreF occurred in five participants. Of these events, two were expected side effects (two cases of headache or malaise), and three were unexpected (one case each of Bell’s palsy, abdominal pain with elevated liver enzymes, and pericarditis, or inflammation of the membrane surrounding the heart).

    A total of 50 fatal SAEs occurred (17 in the RSVpreF group and 33 in controls), but none were considered related to the vaccine. By the end of the first season of follow-up, 146 fatal events had occurred in RSVpreF recipients, and 120 had occurred in controls; the between-group difference was not statistically significant.

    “An estimated 470,000 to 787,000 RSV-related hospitalizations occur annually among older adults in industrialized nations, and with the estimated vaccine effectiveness observed in this trial, approximately 416,500 to 655,500 of these events could be prevented with the RSVpreF vaccine if the vaccine effectiveness was identical in all populations,” the authors wrote. “Moreover, the true burden of RSV is probably underestimated, in part because of limited testing.” 

    Significantly lower VE in immune-compromised adults

    The second study, which also aimed to determine RSV hospitalization rates among adult patients aged 60 years and older, was published in JAMA.

    Researchers with the US Centers for Disease Control and Prevention (CDC) led the multicenter, test-negative, case-control study of 6,958 adult RSV patients hospitalized for acute respiratory illness at 1 of 26 centers in 20 US states from October 2023 to March 2024 or October 2024 to April 2025 and tested within 10 days of illness onset. 

    Case-patients (821) tested positive for RSV only, while controls (6,137) tested negative for RSV, SARS-CoV-2, and flu. The median participant age was 72 years, 50.8% were women, 62.0% were White, 20.1% were Black, and 26.3% had weakened immune systems. In total, 63 case-patients (7.7%) and 966 controls (15.7%) were vaccinated against RSV.

    The researchers obtained demographic and clinical data from patient interviews and electronic health records, estimating a 58% VE a median of 233 post-vaccination during two respiratory virus seasons, regardless of RSV subtype. VE was 69% when vaccination occurred in the same season before symptom onset and 48% when it occurred the previous season, but these estimates weren’t significantly different.

    One dose is recommended for all adults aged 75 years or older and those aged 60 to 74 years at increased risk of severe RSV; however, duration of protection is unknown.

    The vaccine was 46% effective in adults aged 60 to 74 years and 68% among those aged 75 or older. Protection against poor in-hospital outcomes was maintained over 2 years, with a VE against invasive mechanical ventilation or death of 72%.

    A sensitivity analysis limited to adults with healthy immune systems found no VE difference between adults aged 60 to 74 years (67%) and older patients (68%). VE was significantly lower among immune-compromised adults (30%) than among adults with healthy immune systems (67%) in both seasons and among those with cardiovascular disease (56%) versus those without (80%).

    RSV vaccines for adults aged 60 years and older became available in the United States in 2023. “One dose is recommended for all adults aged 75 years or older and those aged 60 to 74 years at increased risk of severe RSV; however, duration of protection is unknown,” the investigators wrote, adding that the CDC’s Advisory Committee on Immunization Practices expanded RSV vaccination to adults aged 50 to 59 years at elevated risk of severe RSV.

    Need to determine revaccination intervals

    Risk factors for RSV hospitalization despite vaccinated status were having a higher median Charlson Comorbidity Index score (meaning having underlying medical conditions) and a greater proportion of moderate or severe immune-compromising conditions (44.4% vs 22.2%). 

    In addition to Abrysvo, Arexy (made by GSK) and mRESVIA (Moderna) have also been recommended for use in older adults. The first two are protein-subunit vaccines recommended in June 2023, and the latter is an mRNA vaccine recommended in June 2024. In this study, of the 953 vaccinated patients with known vaccine-manufacturer, 55.5% received Arexvy, 44.2% received Abrysvo, and 0.3% received mRESVIA.

    Early findings suggest certain subpopulations, including adults with immunocompromise and those with cardiovascular disease, may require additional doses of RSV vaccine earlier than those without these conditions.

    “The findings of effectiveness of RSV vaccines during 2 seasons are consistent with findings from prelicensure RSV vaccine trials,” the authors wrote. “However, early findings suggest certain subpopulations, including adults with immunocompromise and those with cardiovascular disease, may require additional doses of RSV vaccine earlier than those without these conditions.” 

    “As RSV vaccine policy for adults evolves, ongoing monitoring of RSV VE during subsequent seasons is needed to more fully characterize waning of protection and to inform revaccination intervals,” they concluded.

    In 2024, the study group published a study on the VE of RSV vaccines against related hospitalization during the first season of use (2023 to 2024) in a diverse population in which nearly a quarter of patients had moderately or severely weakened immune systems. 

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  • Scientists Respond to the Planned Termination of the Only U.S. Antarctic Research Vessel – Lamont-Doherty Earth Observatory

    1. Scientists Respond to the Planned Termination of the Only U.S. Antarctic Research Vessel  Lamont-Doherty Earth Observatory
    2. Doomsday Glacier at risk—the US loses its only scientific icebreaker in Antarctica, and experts fear a lost decade of data  Pedirayudas.com
    3. The withdrawal of the icebreaker Nathaniel B. Palmer leaves the United States blind to the “Doomsday Glacier”—jeopardizing research that could save the country’s coastlines  La Grada

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  • Alternate flood management possibilities

    Alternate flood management possibilities

    After the widespread destruction wreaked by the 2010 floods in Pakistan, it took the government five years to devise a comprehensive national flood protection plan. This ten-year plan envisioned several new infrastructural interventions including the construction of more embankments, dikes, spurs, retaining walls and diversion channels. This plan also identified the need to improve the largely neglected national drainage infrastructure. Many of these ambitious plans, however, remained confined to paper.

    The massive devastation caused by the 2022 floods again prodded policymakers to reiterate the need for Integrated Flood Risk Management, which proposed pursuing a blend of ‘hard’ infrastructure and more nature-based solutions to minimise flood damages. Yet, the lack of attention paid to implementing such a holistic strategy was again evident given the havoc wreaked by the current monsoonal floods.

    It is time for our policy planners and implementers to take the need for flood mitigation more seriously. Nature-based solutions merit particular attention as they offer the possibility of bolstering flood resilience without requiring a lot of capital, which is often secured via taking on more foreign loans. Pakistan already has some flood diversion and storage infrastructure in the form of barrages and canals, but these structures are heavily geared towards enabling irrigation rather than flood absorption. Varied experts have recommended building more flood retention reservoirs and reviving natural floodplains to ecologically manage the increasing intensity of climate charged monsoonal floods.

    Attention has also been drawn to the possibility of channeling floodwater into ponds, wetlands or artificial lakes. ‘Floodwater harvesting’ or ‘managed flood retention’ can reduce peak flows downstream, thus lowering the risk of destructive floods. This stored water can then percolate down to aquifers via recharge basins to replenish depleted groundwater reserves and be pumped out for use during dry months. These are not merely theoretical suggestions.

    Adelaide in Australia has created many recharge basins. Pakistan now seems poised to do the same via the ‘Recharge Pakistan’ initiative, which finally began its implementation phase last year. One major activity of this initiative is to create recharge basins and retention areas across DI Khan, Ramak, Manchar and Chakar Lehri watersheds. Lessons learnt from these efforts must be used to create replicable retention models which can be scaled up significantly to curb flooding.

    Major rivers like the Indus carry enormous flood volumes, so creating a small number of small ponds or other retention areas will not be enough. Floodwater is also silt-laden, so ponds and artificial lakes will also silt up quickly and thus need regular maintenance. Also, creating new flood retention areas may require resettlement of communities, which is always a contentious process. However, these are not insurmountable problems, and adopting such nature-based solutions is much less damaging and disruptive than creating more concrete-laden dams or barrages.

    Other innovations worth paying attention to include Chinese ‘sponge cities’ which aim to integrate green infrastructure (parks, wetlands, permeable pavements, green roofs) to absorb, store and reuse urban floodwater. In Karachi, some ‘sponge city’ principles are being piloted to reduce urban flooding. Lahore has set up some underground rainwater storage tanks as well. And Islamabad has established several groundwater recharge wells. If these initiatives yield positive results, then housing societies and commercial buildings could be required to invest in such measures to better manage flash floods and help stabilise urban water tables.

    The private sector and civil society can also step forward to help devise more small-scale flood retention areas. Cumulatively, such efforts have the potential to not only make Pakistan more climate resilient, but more water secure as well.

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  • “High Heels Are My Kryptonite”: Coco Gauff Debuts A Miu Miu Curation With a Tennis-Themed Party

    “High Heels Are My Kryptonite”: Coco Gauff Debuts A Miu Miu Curation With a Tennis-Themed Party

    Held at Miu Miu’s opulent, multi-level 57th Street flagship in Midtown Manhattan, the entire second floor of the boutique was transformed into a tennis court dedicated to Gauff’s collection debut. A bright-green turf that resembled a grass court filled the space, with her wardrobe pieces meticulously displayed around it. Gauff graciously posed for photos with a throng of guests and chatted happily as partygoers perused the racks while sipping Honey Deuce—the signature cocktail of the US Open—and nibbling mini vanilla-and-lime macarons designed to look like tennis balls.

    “For the Miu Miu Select collection, I tried to reflect what my closet looks like. I tried to include things that I wear on the court and things that I wear off-court, and that’s mixing masculine and feminine pieces together,” Gauff said. “It was important to put in something for everyone and for them to be represented. So, I wanted to make sure that it wasn’t just all about me, but also for everyone that I see.”

    One item missing from her collection: high heels. Don’t expect the 21-year-old tennis star to be wearing stilettos anytime soon. “There’s a reason why you don’t see me in heels that much—I’m really bad at walking in them,” she laughed. “Other than maybe going to church, the last time I wore heels was at the Oscars. You can’t show up to the Oscars wearing sneakers!” Gauff isn’t completely forgoing stilettos, though. “I do enjoy the look of them. I think they elevate an outfit, and a lot of times I do want to wear them, but I haven’t mastered the comfort and ignoring the pain, so that’s why I am a sneaker girl at heart. High heels are my Kryptonite!”

    Fortunately, Gauff had on her Miu Miu x New Balance 530 SL sneakers and was able to hit the dance floor at last night’s bash. The third floor of the boutique was converted into a moody disco club with dark-red lighting. Guests sipped tequila–yuzu citrus cocktails as a DJ spun remixes of chart-topping hits, while others lined up at an oversized gumball machine filled with Miu Miu–branded tennis balls.

    By 8:30 p.m., Gauff and her team strolled out of Miu Miu’s flagship in comfort after enjoying some non-alcoholic Honey Deuces.

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  • Apple’s AirPods Live Translation isn’t available in the EU

    Apple’s AirPods Live Translation isn’t available in the EU

    Earlier this week, Apple unveiled the iPhone 17, iPhone 17 Pro, iPhone 17 Pro Max, iPhone Air, and the AirPods Pro 3. The new earbuds come with Live Translation, which is also available for the AirPods 4 with ANC and the AirPods Pro 2 on the latest firmware version and paired to an iPhone running iOS 26 – which is coming out in just a few days.

    But Live Translation isn’t available in the EU, according to Apple’s own feature availability page. Specifically, the page says:

    Live Translation with AirPods is not available if you are in the EU and your Apple Account Country or Region is also in the EU.

    That’s obviously not good news for people in the EU who were eager to try out this feature. Do note that Live Translation is currently limited to English (US, UK), French, German, Portuguese (Brazil), and Spanish.

    Later this year, Italian, Japanese, Korean, and Chinese (Simplified) will also be added. It’s unfortunately unclear whether the feature will start working in the EU in the near future, later on, or never.

    Of course, there are other reasons to get the AirPods 3 in the EU, including the improved ANC, smaller size, better battery life, and built-in heart rate monitor.

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  • 108 million degrees: Solar flares are far hotter than thought, study suggests

    108 million degrees: Solar flares are far hotter than thought, study suggests

    Our sun’s fiery flares are even more extreme than scientists had thought, blasting particles to temperatures six times hotter than earlier estimates, according to new research.

    Solar flares are colossal explosions in the sun’s atmosphere that hurl out bursts of powerful radiation. These events are notorious for disrupting satellites, scrambling radio signals and potentially posing dangers to astronauts in space.

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  • Prince Harry beaks silence after emotional reunion with father King Charles: ‘Yes, he’s great’

    Prince Harry beaks silence after emotional reunion with father King Charles: ‘Yes, he’s great’

    Prince Harry has spoken about his long-awaited meeting with his father, King Charles III, marking their first face-to-face conversation in more than 19 months.

    The Duke of Sussex, 40, arrived at Clarence House, the King’s London residence, on Wednesday (September 10) for what is described as “a private tea”. The meeting lasted nearly an hour and was the first time the two had met since February 2024, shortly after Charles revealed his cancer diagnosis.

    Harry’s reflection on the reunion

    At an Invictus Games event later that day, the Duke of Sussex when asked by a reporter about his father following the meeting, Harry said simply: “Yes, he’s great. Thank you.”

    Longstanding rift

    Notably absent from the gathering was Prince William, who has been estranged from his younger brother and Meghan Markle for years.

    Harry previously admitted that strained ties had left him cut off from his father. In a May interview with the BBC, he said: “My father won’t speak to me because of this security stuff … but I would love reconciliation with my family. There’s no point in continuing to fight anymore. And life is precious.”

    “I don’t know how much longer my father has … but it would be nice to reconcile,” he told the BBC earlier this year.

    Past tensions

    The Duke has been outspoken about his challenges growing up within the monarchy, especially after stepping back from royal duties in 2020 and relocating to California with wife Meghan Markle. His memoir Spare and television interviews have only deepened tensions.

    “Of course some members of my family will never forgive me for writing a book,” Harry said earlier this year.

    Tribute to Queen Elizabeth II

    Before the reunion, Harry visited St George’s Chapel at Windsor Castle to honor the late Queen Elizabeth II on the third anniversary of her death. He laid a wreath and flowers at her resting place, paying tribute to his grandmother.

    A step toward reconciliation?

    Harry’s brief but positive comments about his father offered a glimmer of hope for reconciliation.

    The meeting comes as King Charles, 76, continues cancer treatment and as Harry balances his role as founder of the Invictus Games with ongoing tensions within the royal family.

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  • Floods and Pakistan

    Floods and Pakistan

    By now everyone in Pakistan who watch TV should know the science and interrelationship of cloud and glacial burst, flash floods, deforestation and landsliding, hopefully the difference between Cusec as a measure of flow quantum and thus intensity, and MAF as the volume of water which flows through our rivers, floods or no floods. And if you know the science of it, one must also know the consequences, the catastrophe and the loss associated with such levels of water flow. One must also be able to thus place in perspective the politics associated with the issue of water between provinces or between states or the irony of it.

    Here is a bit more of science – in fact there is much more but I don’t want to laden you with it; let that lie in the domain of specialists. The water flow in our rivers has reduced to around 100 MAF annually from 135MAF that they carried in 1947. Population growth and reduction in the flow together have pushed Pakistan in the category of water scarce nations. Of the 100 MAF Pakistan stores only 16 MAF in its dams and reservoirs which is abysmal.

    Per one estimate, this year with excess rainfall in catchment areas, augmented by cloud and glacial burst, the water that will flow or spread through our rivers will be in the order of 185-195 MAF. Almost twice the amount usually carried. Sadly, it will cause, and has already, caused loss of precious lives, home and hearth, livestock and devastation of the crops which were under cultivation causing cumulative loss of billions of dollars in relief, rehabilitation, recovery and economic loss, making deficiencies in food, health and exports an existential challenge. What is more, almost all of the water will either flow into the ocean — none being preserved and stored, because we have no storage facilities — or stand idle in perfectly good agricultural fields turning brackish over time and salinating our lands. This is quadruple whammy.

    And yet we may not have seen such a consequence. Most of it, if not all, is through adverse human intervention and even poorer leadership which has persistently failed to comprehend the challenges that now stare us in the face and have caused immense devastation. From science must emerge the art of management as well as leadership but only if the science of it is first well understood. 185 MAF flow in the rivers will anyway be too much to carry for any river system if the inherent capacity is far lower but there is a case to be made for appropriate infrastructure to manage and control the flow in floods.

    Usually, the rivers are a stream only for most of the year. Is there a case permitting controlled dredging by the construction companies and builders to remove the layers of sand that have almost filled the rivers till their upper edges where water above the holding capacity will spread out? Similarly, the embankments can be deepened and reinforced to contain the water flow. Just as we desilt canals in the off season, let this be a recurrent work on the rivers too. Incremental improvement will help mitigate a super-flood.

    Next is channeling the water flow. There was a huge furor on digging Thar canals in parochial characterisation of a common national asset. Just as we have deferred nay obviated the thought of Kalabagh Dam in our consideration, we gave up on digging more canals.

    The Sutlej came to life in a ferocious return and remains the river in fury as the rest have tended to settle down. With a canal system for and through Thar, it would have made for a perfect water reserve. Further, it would turn arid land cultivable over time with right treatment. Of course, the canals would take a long time building and the waters would have done what they did through the channels that exist at this time but as climate threatens perpetually there will be more such deluges. Maybe we will be able to store better and save better and be better and rationally ready to mitigate the loss and use it as an opportunity to benefit out of.

    Canals in Thar will still lie in Thar and should be designed to carry and distribute water when even Indus can hold it in its banks. Climate change will make that possible more often than we like. Should bane not turn into a boon with little innovation and breaking out of stereotypical shackles? Dams, reservoirs and canals remain the primary sources of mitigating floods and storing water. They must remain our topmost priority for the deluges that will now be the routine.

    Urban flooding is the result of unplanned urban growth without compatible infrastructure. Our roads, water and electricity, and sewerage infrastructure in cities can only support so many people. Our cities have only grown in multiples outrunning their capacity. Karachi is a prime example. It will be very difficult to dislodge people now but whatever main arteries of water and sewage remain will need seasonal clearing to keep them functional and running. These are known steps but are never paid attention to by municipal authorities. Even routine administrative function can ensure this little is done.

    Subsequently, over time, planned distribution of populations that crowd our city choke points need to be relocated. Infrastructure to support such dislocation must be built in parallel. Rural to urban migration must be curbed. For it, money needs to be spent equitably in all areas to enable growth and job opportunities closer to population points.

    Climate change is a constant. It isn’t going away. It will define the environment in which humanity will need to coexist. It will rain even more next year and cause severer floods. Infrastructure will take time to develop. Meanwhile, what shall our flood mitigation strategy be with what we have? Can we put in place improved water aquifers to channelise urban flooding into useable storage, at least in Lahore where some sort of rudimentary infrastructure exists?

    Institutions such as Flood Control Commission or a similar entity along with better equipped and better led Disaster Management and Mitigation Authority at Federal and Provincial levels need to be established. It can be enhanced later to include all types of contingencies needing emergency rescue and relief measures. It should be a specialist-manned and specialist-led entities. We have played enough by keeping generalists in the lead in our bureaucracy. It is time to make that change.

    We are not short of resources or structures, just that over time we let those structures decay with inattention and lack of scrutiny to keep those relevant. It is time to revamp the entire governance paradigm if we must retain the integrity and relevance of government with the people of Pakistan. We can’t give them health or education, we should at least be able to save their lives when catastrophes strike.

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  • André Onana leaves Man United for Trabzonspor on loan

    André Onana leaves Man United for Trabzonspor on loan

    Manchester United goalkeeper André Onana has completed a season-long loan move to Trabzonspor, the Premier League club confirmed on Thursday.

    Onana makes the move to the Turkish Super Lig after an inconsistent two-year spell at Old Trafford and a poor start to this season that saw the Cameroon international usurped by Altay Bayindir as United’s No. 1.

    Sources told ESPN that there is no loan fee or an option to make the deal permanent, meaning Onana will return to Manchester next summer. The sources added that United will not have to pay any of Onana’s wages while he is away on loan.

    Onana made the decision to leave United following Senne Lammens’ arrival at the club from Antwerp on deadline day after wanting to stay and fight for his place at the club earlier in the summer, sources told ESPN.

    The 29-year-old joined United in a deal worth an initial £43.8 million ($59.1m) from Inter Milan in 2023.

    – Will Onana’s exit solve anything at Man United?
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    A short club statement read: “Manchester United goalkeeper Andre Onana has joined Trabzonspor on loan for the duration of the 2025/26 season, subject to international clearance and registration.

    “The move has been completed ahead of the Turkish transfer window closing on Friday. We would like to wish Andre good luck.”

    Onana made 102 appearances for United and helped the team win the FA Cup in 2024.

    The Turkish transfer window closes on Friday.

    Following the international break, United return to action away to rivals Manchester City on Sunday.

    Information from ESPN’s Rob Dawson contributed to this report.

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  • Prince Harry 'loved' being back in UK on visit: spokesperson – France 24

    1. Prince Harry ‘loved’ being back in UK on visit: spokesperson  France 24
    2. Harry’s tea with Charles could be small but significant step to reconciliation  BBC
    3. Prince Harry says King is ‘great’ after they have private tea in first meeting for 19 months  Sky News
    4. King Charles and Prince Harry finally reunite after 19 months apart  CNN
    5. Prince Harry friends make shocking revelations about the Duke  Geo.tv

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