Author: admin

  • Triglyceride levels substantially reduced with olezarsen compared to placebo

    Triglyceride levels substantially reduced with olezarsen compared to placebo

    Olezarsen decreased levels of triglycerides compared with placebo in patients with moderate hypertriglyceridemia and elevated cardiovascular risk, according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

    High levels of triglycerides are an important risk factor for atherosclerotic cardiovascular disease (ASCVD) and yet the effects of current therapies are modest. Olezarsen targets the mRNA of apolipoprotein C-III, which inhibits triglyceride clearance. Olezarsen has been shown to lower triglyceride levels in small phase II trials and in patients with very high triglyceride levels. We investigated the efficacy and safety of olezarsen in patients with moderate hypertriglyceridemia at high ASCVD risk in the ESSENCE-TIMI 73b trial.”


    Doctor Brian Bergmark, Principal Investigator, from the TIMI Study Group, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

    The placebo-controlled, double-blind phase III ESSENCE-TIMI 73b trial was conducted at 160 sites in North America and Europe. The trial included adult patients with moderate hypertriglyceridemia (triglycerides 150−499 mg/dL) and elevated cardiovascular risk due to an established diagnosis of ASCVD or increased ASCVD risk as a result of type 2 diabetes mellitus and age ≥55 years. Patients were expected to be on optimised stable low-density lipoprotein-cholesterol (LDL-C)-lowering therapy at enrolment. The ESSENCE-TIMI 73b trial also included patients with severe hypertriglyceridemia (triglycerides ≥500 mg/dL). The primary analytic cohort was patients with moderate hypertriglyceridemia as patients with severe hypertriglyceridemia are being studied in dedicated, separate trials.

    The primary analysis population included 1,349 patients with moderate hypertriglyceridemia and elevated cardiovascular risk who were randomised to olezarsen 50 mg (n=254), olezarsen 80 mg (n=766) or placebo (n=329) given every 4 weeks via subcutaneous injection for 12 months. The primary endpoint was the percent change from baseline in triglyceride levels at 6 months compared with placebo.

    The primary analysis population had a median age of 64 years and 40% were women. The median triglyceride level at baseline was 238.5 mg/dL.

    At 6 months, olezarsen significantly reduced levels of triglycerides: the placebo-adjusted least-squares mean difference in percent change from baseline was −58.4 percentage points for olezarsen 50 mg and −60.6 percentage points for olezarsen 80 mg (both p<0.001 vs. placebo).

    In the placebo group, 12.5% of patients had triglyceride levels <150 mg/dL at 6 months, compared with 85.0% of patients on olezarsen 50 mg and 88.7% on olezarsen 80 mg (p<0.001 for both). At 12 months, the proportions were 20.6%, 82.8% and 85.0% for placebo, olezarsen 50 mg and olezarsen 80 mg, respectively (p<0.001 for both vs. placebo). Olezarsen significantly reduced levels of other lipoproteins − remnant cholesterol, non-high-density lipoprotein cholesterol and apolipoprotein B – with no significant effect on LDL-C.

    The incidence of serious adverse events appeared similar: 9% with olezarsen 50 mg, 14% with olezarsen 80 mg and 11% with placebo. Liver transaminase elevations to any degree above the upper limit of the normal range were more common with olezarsen 50 mg (34.2%) and olezarsen 80 mg (38.3%) than with placebo (17.6%) (both p<0.001); however, clinically meaningful increases were rare and similar across groups.

    Summarising, Doctor Bergmark said: “In a population with moderate hypertriglyceridemia and elevated cardiovascular risk, monthly olezarsen resulted in substantial triglyceride lowering greater than would be expected from currently available therapies, with more than 80% of patients treated with olezarsen achieving normal triglyceride levels.

    Source:

    European Society of Cardiology (ESC)

    Continue Reading

  • Microsoft denies recent Windows 11 update is bricking SSDs

    Microsoft denies recent Windows 11 update is bricking SSDs

    The recent Windows 11 security update didn’t cause those SSD failures, according to Microsoft (via BleepingComputer). But the root cause is still unknown.

    Users began reporting their SSDs and HDDs getting bricked soon after installing a Windows update (KB5063878), released by Microsoft on Aug. 12. The issue was first noticed by Japanese users who reported failed and corrupted drives when working with large files or lots of files on SSDs that were over 60 percent full and had the new update installed. Users reported problems with SSD drives from brands including Corsair, Phison, Fikwot, Maxio, and others.

    Microsoft investigated the issue and said they were unable to reproduce the issue, finding no link between between the Windows 11 update and the bricked drives. “After thorough investigation, Microsoft has found no connection between the August 2025 Windows security update and the types of hard drive failures reported on social media,” said Microsoft said in an update to the service alert reported by Bleeping Computer.

    Mashable Light Speed

    Microsoft worked with controller-maker Phison to investigate why SSDs with their chips failed. Phison also said it was unable to reproduce any issues, but “continues to closely monitor the situation in collaboration with our industry partners,” in a statement to Neowin.

    Until the root cause is determined, Phison advised users to use a heatsink or thermal pad to prevent the device from overheating during long, power-heavy sessions. Additionally, a Phison spokesperson told BleepingComputer that users with over 60 percent storage used should “avoid downloading, copying, or writing large files” that are in the tens of gigabytes.

    Continue Reading

  • ‘The walls collapsed around me’: Afghans describe quake devastation | Afghanistan

    ‘The walls collapsed around me’: Afghans describe quake devastation | Afghanistan

    It was almost midnight when Hameed Jan was jolted awake in his bed by a deep rumble. Powerful tremors were shaking his small house in Piran village, in Afghanistan’s Kunar region, and he could see the walls beginning to crack.

    “I jumped out of bed and rushed to where my children and parents were sleeping,” Jan said. “I managed to rescue two of my children and brought them outside to safety. I went back inside to save my younger siblings, but as I did the roof and walls collapsed around me.”

    As the magnitude-6 earthquake hit eastern Afghanistan late on Sunday night, Jan found himself buried in the rubble of his own house. As much as he tried to claw at the debris, he struggled to push his head through the wreckage. It took villagers five hours to finally free him. When he finally broke through, he was greeted with scenes of tragedy and devastation.

    His wife, two sons and two brothers were among the dead after the powerful earthquake had razed entire villages across the region to the ground. In the poverty-stricken, mountainous terrain of Kunar, most homes in the affected villages had been made only of mud, giving people little defence from the debris and floods caused by the earthquake when it struck as they slept. Most homes lay in piles of rubble or had been washed away entirely.

    Damaged buildings in Kunar. Photograph: EPA

    “It felt as if the entire mountain was collapsing on us,” Jan said. “Our village has been completely devastated and residential areas wiped out.”

    The official death toll stood at 800 on Monday evening, with more than 2,500 injured, and was widely expected to rise significantly. Many in the villages of Kunar remained unaccounted for and rescuers continued to pull bodies from the rubble as all local hospitals declared a state of emergency.

    The Taliban, who took control of the country more than four years ago when its internationally recognised government collapsed, dispatched helicopters but many areas remained impossible to access.

    Rescue efforts after Afghanistan earthquake kills more than 800 – video

    Sanaullah, another resident of Kunar province, had been away from his village when the earthquake struck. When he travelled back on Monday, he found that his house had been reduced to rubble and his brother had been killed alongside his five children. “It is the story of each and every house here,” he said. “Everyone I know here has lost at least three to five family members.”

    Abdul Rahim, a cleric in Kunar, said graveyards in Mazar valley in Kunar were now overflowing with the dead. “Everywhere people are crying and embracing one another following a mass funeral,” he said. “The death toll is so high that graveyards are overflowing, and local people are busy digging graves in advance as bodies arrive every half hour.”

    Many of those affected were critical of the rescue efforts by the Taliban, which was widely seen to lack the resources, manpower and funds to deal with a crisis on this scale. Since the Taliban retook power in 2021, it has become increasingly difficult for NGOs to operate in the country, particularly amid the draconian ban on women’s employment and education, and most foreign governments have withdrawn aid from Afghanistan, now one of the poorest countries in the world.

    Afghan men search for their belongings in the rubble of a collapsed house. Photograph: Reuters

    Sohail Shaheen, a Taliban spokesperson, called on international organisations to step in and offer assistance in the wake of the disaster. “Many villages are not accessible yet,” he said. “I fear the casualties are very high.”

    One resident from the Maza Dara area, who asked to remain anonymous to speak freely, criticised the Taliban rescue efforts. “There are women and children pleading for help but there are no authorities present to help them,” he said.

    “Everyone is trapped under the rubble and we are helpless and seeing them dying in front of our eyes,” he added. “There is no one here to help those buried and alive in the debris. There is no one here to remove the dead.”

    Continue Reading

  • Google DeepMind Chief Scientist says AI already surpasses humans in most tasks: ‘Most people are not that good at…’

    Google DeepMind Chief Scientist says AI already surpasses humans in most tasks: ‘Most people are not that good at…’

    With artificial intelligence systems getting better day by day, the raging question in the AI community has been whether the new models will soon be able to surpass humans at most tasks we do today or attain a state of Artificial General Intelligence (AGI). Google DeepMind Chief Scientist Jeff Dean, while steering clear of the term AGI, believes that the current AI models may already have surpassed humans in most day-to-day tasks, with a few caveats.

    In an episode of the Moonshot Podcast, Dean says that the current models are “better than the average person at most tasks” that do not require physical activity.

    “Most people are not that good at a random task if you ask them to do that they’ve never done before, and you know some of the models we have today are actually pretty reasonable at most things.”

    “You know, they will fail at a lot of things; they’re not human expert level in some things, so that’s a very different definition and being better than the world expert at every single task,” Dean cautioned.

    The host then asked Dean how far away the current models are from making breakthroughs faster than humans. To which Dean replied, “We’re actually probably already you know close to that in some domains, and I think we’re going to broaden out that set of domains.”

    “There will be a lot of domains where automated search and computation actually can accelerate progress — scientific progress, engineering progress,” he said. “All these things I think are going to be important for advancing what we as people can do over the next five, 10, 15, 20 years,” he added.

    The one area that Jeff Dean won’t talk about:

    Dean, however, chose to stay clear of the AGI debate, in part because the term does not have any clear definition within the field of artificial intelligence.

    “The reason I tend to steer away from AGI conversations is lots of people have very different definitions of it and the difficulty of the problem varies by like factors of a trillion.”

    Dean’s boss and Google DeepMind CEO Demis Hassabis is more optimistic about AGI and claimed in a recent interview with WIRED that the breakthrough would be achieved in the next 5-10 years.

    Continue Reading

  • Nano Banana AI Launches in Los Angeles, Setting New Standard for Consistent, Intuitive Image Editing – GlobeNewswire

    1. Nano Banana AI Launches in Los Angeles, Setting New Standard for Consistent, Intuitive Image Editing  GlobeNewswire
    2. Nano Banana: Image editing in Google Gemini gets a major upgrade  The Keyword
    3. Google aims to be top banana in AI image editing  Axios
    4. When AI goes bananas  Tech in Asia
    5. Review | Masterful photo edits now just take a few words. Are we ready for this?  The Washington Post

    Continue Reading

  • Wakefield mining museum strike extended in row over pay

    Wakefield mining museum strike extended in row over pay

    Chloe AslettBBC News, Yorkshire

    Nicola Rees/BBC About 20 staff members on the picket line holding up signs with Unison's purple branding. They are mostly in casual clothing, many seemingly in their 60s.Nicola Rees/BBC

    The strike at the National Coal Mining Museum was now due to end on 12 October, Unison said

    A strike by more than 40 workers at the National Coal Mining Museum is to be extended until mid-October after the chief executive quit talks, a union has said.

    Members of Unison at the museum in Wakefield, many of whom, the union said, earned about £12.60 an hour, began a four-week strike in August calling for higher pay.

    Less than a week before the walkout, the museum offered a pay rise of 5%, or 80p more per hour, whichever was higher, but Unison said it was a “worse offer” than was previously discussed.

    Philip Marshall, chair of trustees, said the museum was “committed to fair and ethical pay”, but did not consider Unison’s claim for 5% or £1 more per hour to be “reasonable or affordable”.

    The trustees’ offer would lead to many employees receiving a rise of 14% over two years, and the charity would have to “find efficiencies and make savings” to afford it, Mr Marshall said.

    “The trustees were keen to support our chief executive and her team in finding a speedy resolution to the dispute,” he added.

    But Unison said museum chief executive Lynn Dunning’s “refusal” to return to pay talks had left it “no option but to extend the action further” and moved the strike’s end date from 14 September to 12 October.

    National Coal Mining Museum A general view of buildings at the National Coal Mining Museum in Wakefield. The building in the foreground has beige coloured bricks with a green door. Several red brick buildings stand in the background, with green doors and railings, with the Museum's red pit wheel at the top of the tallest building.National Coal Mining Museum

    Museum workers voted for strike action after claims a promised pay rise was pulled

    A Unison spokesperson said: “The union wants the chief executive to either step up and engage in meaningful talks to bring the dispute to an end, or step aside and let someone else get it sorted.

    The museum’s spending on private security guards and alternative attractions during the strike could have funded the pay claim “several times over”, according to the union.

    Responding, Mr Marshall said the museum had been incurring additional costs, including on security, but “not at the levels being suggested” by the union, which had estimated “almost £50,000” of extra spending.

    Some of the guides on strike at the National Coal Mining Museum had been part of the year-long miners’ strike in the 1980s, Unison said.

    Nicola Rees/BBC A headshot of a woman, smiling at the camera, with red lipstick, black hair, and a bright royal blue blazer. She is holding a purple sign which says "official picket" in white capital letters.Nicola Rees/BBC

    Rianne Hooley, from Unison, said striking staff were “desperate” to return to work

    Rianne Hooley, Unison’s regional organiser, said: “This isn’t just a job. It’s an opportunity [for staff] to keep the area’s coal mining heritage alive through their storytelling.

    “They’re desperate to be back doing what they love, but they want to be paid fairly and treated with respect.

    “If the chief executive continues to refuse to negotiate, staff have no choice but to continue their strike.”

    Mr Marshall said the museum remained “fully open to constructive dialogue” with the union, in an effort to find a solution which supported “staff and our long-term sustainability”.

    Continue Reading

  • Vivo takes aim at Apple with lighter, cheaper VR headset

    Vivo takes aim at Apple with lighter, cheaper VR headset

    When Apple’s Vision Pro arrived last year, it was hailed as a glimpse into the future of mixed reality. But its high price and heavy build drew criticism.

    Now, Chinese smartphone maker Vivo has stepped into the arena with its own answer — the Vivo Vision — a headset that looks strikingly familiar, but comes with some important differences.

    Unveiled during Vivo’s 30th anniversary event, the Vivo Vision Discovery Edition shares the sleek design and gesture-based interface of Apple’s headset. Yet it weighs only 398 grams, roughly a third lighter than its American rival, and is also expected to cost about one third of the price. That difference alone may draw many curious users.

    Keep updated, follow The Business Standard’s Google news channel

    It is a familiar strategy for Chinese hardware makers: offering high specifications at lower prices to beat the competition.

    The headset features two micro-OLED displays with a combined 8K resolution, designed to produce sharp, cinema-like visuals. It runs on Qualcomm’s Snapdragon XR2 Plus Gen 2 platform, which delivers more powerful graphics and faster processing than its predecessor.

    Eye tracking and fingertip gesture recognition allow users to control the system without physical controllers, while strap options offer flexibility for comfort.

    If the suggested price of around 10,000 yuan (roughly £1,100) holds true, the Vivo Vision would significantly undercut Apple’s Vision Pro, which starts at nearly 30,000 yuan in mainland China.


    Continue Reading

  • digital outpatient tech reduces heart failure readmission

    digital outpatient tech reduces heart failure readmission

    KiActiv’s digital cardiac rehabilitation programme has significantly reduced heart failure (HF) hospital readmissions while cutting healthcare costs.

    The 12-week therapy, which offers HF outpatients personalised daily physical activity regimens to help reduce the risk of cardiac event recurrence upon discharge, has been seen to reduce HF readmissions by 70% after 90 days.

    Novel data presented at the 2025 European Society of Cardiology (ESC) conference from a programme at the Liverpool University Hospitals NHS Foundation Trust has also revealed the technology’s potential to improve the mental well-being and quality of life of patients, offering improvements in 74% and 58% of patients, respectively.

    Notably, KiActiv also appeared to be superior to standard face-to-face HF cardiac rehabilitation programmes that are generally used by UK hospitals, with patient uptake being six-fold higher than traditional methods.

    The positive early outcomes of this programme follow the UK National Institute for Health and Care Excellence’s (NICE) call to conditionally recommend the technology to adult cardiovascular disease outpatients for cardiac rehabilitation in August 2025.

    This aligns with the NHS’ recently announced 10-Year Plan, which will see the public health body transition from analogue to digital, utilising technology to empower patients to pursue self-care treatment options.

    According to Dr Rajiv Sankaranarayanan, consultant cardiologist at the Liverpool University Hospitals NHS Foundation Trust and presenter of KiActiv’s ESC abstract, the technology is believed to be a “world-first” and will support efforts to boost patient rehabilitation rates outside of the hospital setting.

    Though the findings from this programme are based on KiActiv’s potential in HF outpatients, the technology’s creator, Tommy Parker, has touted the programme’s efficacy in other long-term conditions such as diabetes, obesity, long Covid and chronic fatigue syndrome.

    According to a NICE assessment, the technology will save the NHS £43.40 per £1 spent after ten years – highlighting its potential to reduce treatment costs for the public health service.

    Moving forward, KiActiv will work to solidify its footing in the ever-growing digital health market, which GlobalData, parent company of Medical Device Network, valued at $7bn in 2024.

    The shift towards patient-centric and convenient outpatient options will likely further drive up the sector’s value, with GlobalData’s analysts forecasting that the market will be worth $22bn by 2034.

    Currently, Oracle Health – formerly the Cerner Corporation – dominates the market, making just over 21% of the industry’s total revenue during 2024. This is followed by Otsuka Pharmaceutical and Medtronic, who earned $606m and $496m, respectively, in the same year.

    Meanwhile, the UK digital health market was worth $249.6m in 2023.

    “ESC 2025: digital outpatient tech reduces heart failure readmission” was originally created and published by Medical Device Network, a GlobalData owned brand.

     


    The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site.

    Continue Reading

  • Multiple Galaxy Z Fold 7 users report flaking paint issues like the Z Fold 6’s

    Multiple Galaxy Z Fold 7 users report flaking paint issues like the Z Fold 6’s

    Samsung’s latest foldables have only been on shelves for a month, but one is already picking up an unwelcome bit of déjà vu from last year’s Z Fold 6. As Android Authority drew our attention to, multiple Galaxy Z Fold 7 owners are reporting that the paint — or more accurately, the anodized finish — is chipping off their $2,000-plus devices. And in most cases, they swear it’s not from drops or abuse.

    A curious case of chipped paint

    Suspiciously similar to last year’s

    This is what the edge of the Blue Shadow model should look like with no flaking paint.

    Reports started surfacing on Reddit nearly three weeks ago. Multiple posts and comments have emerged containing photos of the aluminum frame showing flakes of missing finish near the power button, around the USB-C port, and along the side rails. One owner, who claims to have “babied my phone the day I purchased it,” said the coating started peeling despite only ever using Samsung’s 25W charger and a high-quality case. Another said they woke up to what looked like a speck of lint, only to discover it was a bare patch of aluminum after the finish chipped away further.

    If this sounds familiar, that’s because it is. The Fold 6 had a nearly identical controversy last year. That prompted Samsung to issue support documentation suggesting poorly grounded third-party chargers could degrade the anodization on its foldables. The company recommended using only first-party power bricks, warning that current leakage from non-OEM chargers might corrode the protective surface.

    However, the latest complaints complicate that narrative. Several users say they only used Samsung’s official charger, while others point out that the anodized layer shouldn’t fail under normal circumstances at all. One particularly detailed comment argued that the aluminum wasn’t treated properly during manufacturing, meaning the finish simply wasn’t bonded to the frame the way it should have been.

    What’s being done about the finicky anodization?

    Samsung-Galaxy-Z-Fold-7-standing-in-silver-blue-black-showing-cameras

    Most reports center on Blue Shadow, with few on Jetblack, and seemingly none on Silver Shadow.

    Samsung’s customer service responses seem mixed. A few users report being told cosmetic damage isn’t covered under warranty since it doesn’t affect performance. Others, like a Z Fold 7 buyer in Denmark, say Samsung arranged a pickup to evaluate whether the defect qualifies for repair or replacement. In at least one case, a service center escalated the issue to corporate for review.

    Still, for a phone that starts at over $2,000, spontaneous paint flaking is more than a minor annoyance. It’s a quality control problem. It also risks undermining confidence in Samsung’s premium foldables at a time when Chinese brands are heating up the competition.

    We’ve reached out to Samsung for comment and will update if the company provides an official response. In the meantime, if you’re the proud owner of a new Z Fold 7, try not to get caught up staring too closely at the frame.

    Continue Reading

  • Robin Wright found it ‘liberating’ to leave US to live in UK

    Robin Wright found it ‘liberating’ to leave US to live in UK

    Robin Wright is the latest Hollywood celebrity to say she’s happily living in the U.K.

    “America is a (expletive) show,” she told The Sunday Times in an interview published Aug. 30. She did not raise political issues in the conversation. “I love being in this country. There’s a freedom of self here. People are so kind. They’re living.

    “They’re not in the car in traffic, panicked on a phone call, eating a sandwich. That’s most of America. Everything’s rush, competition and speed.”

    She concluded: “It’s liberating to be done. Be done with searching, looking and getting 60% of what you wanted.”

    Wright has largely worked in England for the past several years, bouncing between rental homes. In Los Angeles, she says, “Everyone’s building a huge house and I’m just done with all that − I love the quiet.”

    What does mystify her is the British fixation on class, she told the Times. “It’s very evident when you’re in a room and you feel the judgment or the praise of someone who’s more elevated,” she says. “I’m trying to figure it out. Why are you guys so obsessed with who went to this boarding school or this university?”

    While living in the England, “I’ve met my person. Finally,” she said, referencing Henry Smith, a British-Australian architect she’s been involved with about a year. “I love being alone and I’ve done that many times. But I’m, like, I want to grow old with somebody, and travel and see the world.”

    Wright, 59, has been married three times, including to Sean Penn, with whom she has daughter Dylan and son Hopper. She said she doesn’t want to wed again. “No. God no. Why? That’s just unnecessary.”

    Her new Amazon Prime series “The Girlfriend,” a thriller about a mom (played by Wright) with a bad feeling about her son’s (Laurie Davidson) new love interest (Olivia Cooke), streams Sept. 10.


    Continue Reading