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  • You’re definitely having a laugh! Six hot comedy debuts at Edinburgh fringe 2025 | Edinburgh festival 2025

    You’re definitely having a laugh! Six hot comedy debuts at Edinburgh fringe 2025 | Edinburgh festival 2025

    Molly McGuinness: Slob

    “There should be a buffet at every comedy gig,” says Manchester-based Molly McGuinness – and luckily for us, she’s making that happen for her Edinburgh debut. Her laugh-packed sets, served with snacks and a warm conversational style, are inspired by the standup of Caroline Aherne. “I like it to feel as if I’m talking to a friend,” she says. Slob began as a turning-30 existential crisis about reaching your potential, but when a rare disease left McGuinness in a coma, everything shifted. She will share the “bizarre and surreal” experience of coma-induced delirium, tender reflections on “the sweetness of the nurses” that cared for her, and a blossoming love story. “A lot of people feel like a slob, but we’re doing the best we can,” she says.
    Monkey Barrel, 28 July–24 August

    Simple Town

    US group Simple Town make consistently brilliant short films, where everyday conundrums (what’s the meaning of “adroit”? What happens if you’re late for a funeral?) escalate to extremes, or descend into meta-narratives about the absurdity of online content. The foursome, who started performing regularly in New York around 2017, are bringing an hour of “pure sketch comedy” for their fringe debut. Their previous visits to the UK sold out fast. “Our work is somewhere between alternative and crowd-pleasing. Sometimes it’s brainy, ‘comedian’s comedian’ humour, but we also work very hard for the shows to be silly, broad, fast-paced, and fun,” they say. “So hopefully, both kinds of audiences will find something in the show to hate.”
    Pleasance Courtyard, 11–24 August

    Jessica Barton in Dirty Work. Photograph: Paul Westbrook

    Dirty Work

    Australian performer Jessica Barton started out in musical theatre and got her first taste of comedy at French clown school Gaulier. She began to “play using song and movement, physical comedy and clowning”, moved to London and immersed herself in its alternative comedy scene. Dirty Work combines her vocal talents with playful audience interaction. In character as Floppins – a Mary Poppins-esque figure intent on cleaning up the stage – she cleverly explores gendered domestic roles. “Expect to have a lot of fun,” she says. “Expect to be challenged and to rise to the occasion. Especially the men in the audience.” Dirty Work was awarded best newcomer at Melbourne international comedy festival and as she gets deeper into the character: “I’ve enjoyed finding new things within the world I’ve created.”
    Underbelly Cowgate, 31 July–24 August

    Ayoade Bamgboye: Swings and Roundabouts

    Her assured presence and sideways perspective make Ayoade Bamgboye stand out on any lineup, despite having only three years of live comedy under her belt. She had been working as a writer when someone suggested she try it and Bamgboye is always experimenting, incorporating clowning, multimedia forays and different personae into her performances. She “grew up between London and Lagos” and gives a unique twist on observational comedy: “I’m looking at everything as if I’m on safari. I’m a curious silly billy.” Bamgboye says her comedy has sometimes been “confrontational and caustic” with spicy punchlines on racism and colonialism, but with her debut she’s ready to be more vulnerable, too: “Audiences should expect something bittersweet.”
    Pleasance Courtyard, 30 July–24 August

    Sharon Wanjohi: In the House. Photograph: Rebecca Needmenear

    Sharon Wanjohi: In the House

    She first tried standup at university in Southampton (“We had a comedy society where all the nerds went”) and quickly racked up finalist spots at the Funny Women and BBC new comedy awards. Now, Sharon Wanjohi is making her fringe debut with a show about self-help culture and the zeitgeisty coping mechanisms that are “shoved down our throats” every day. “I’m presenting myself as this 90s talkshow host, in the mould of Trisha and Oprah”, Wanjohi says. “I’m satirising self-help, but also breaking out of character to do standup.” You’ll get a gen Z spin on societal issues like the housing crisis, but something “goofy, silly, less grounded in reality,” Wanjohi promises.
    Pleasance Courtyard, 30 July–24 August

    Roger O’Sullivan: Fekken

    This 90s-tinted debut from Irish comedian Roger O’Sullivan explores his relationship with his farmer father via Tekken and the rest of young Roger’s favourite PlayStation games. He started out on Cork’s small comedy scene eight years ago, where “there weren’t really any stakes, so any gig you’d do something new and try the weirdest thing. That’s the mentality I’ve had from early on.” He’s had success online with lo-fi animations, which he works into the show to great effect. “I wanted to end with a callback to retro video games and thought it would be really funny if I learned 3D animation just for that.” Expect warm standup that melds “a little bit of heart with absurdism”.
    PBH’s Free Fringe @ Carbon and Hoots @ The Apex, 2–23 August

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  • The Strad – Tanzania’s Daraja Music Initiative: making an impact through conservation and music education

    The Strad – Tanzania’s Daraja Music Initiative: making an impact through conservation and music education

    Discover more Featured Stories like this in The Strad Playing Hub 

    It’s 6:30am in Moshi, Kilimanjaro region. The sun is starting to rise daily at the same time as it is near the equator. The singing of roosters and other birds blends with the sounds of beeping boda bodas from the nearby road. The snow-covered top of Mount Kilimanjaro is coming out from the clouds. The security guard keeps talking loudly on the phone near the home windows, keeping some volunteers awake. It is another day of teaching at Daraja Music Initiative, the programme that bridges music education and nature conservation.

    The programme was initiated by Michele Von Haugg under the name ’Clarinets for Conservation.’ She got the inspiration to come to Tanzania after seeing a documentary Mpingo – the tree that makes music. Now the programme is run by executive director clarinetist Ian Tyson from New York. First, it was a clarinet-only programme, but later on, the violin was added to it. Some of the students can play both the violin and the clarinet. 

    Mpingo, the African Blackwood tree, is special – it is the national tree of Tanzania. Not only are beautiful carvings made of this durable and expensive tree, but also musical instruments such as clarinets, oboes, and parts of the string instruments such as fingerboards, chin rests, pegs, and bow frogs.

    The tree is over-harvested and not enough replenished, but during the 15 years of the programme, many trees have been planted at local Moshi schools, and students are being taught about the environmental and economic value of the tree and how to take good care of it.

    IMG_3735 2

    The programme is truly building community and empowering students and local families in many ways. A former student of the programme, Michael Boaz, opened his own NGO non-profit organisation in Dar es Salaam called ’Music for Hope’ three years ago. Many older students aspire to travel abroad for the first time and have dreams to come to study in foreign universities to obtain music education degrees.

    Every Thursday, students, together with volunteer teachers, perform at the local coffee shop ’Union Coffee’ owned by a parent of a student. These performances are very special as all students can showcase their skills, like a new scale or just the new three notes that they have learnt on the D-string.

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    A touching moment for me was playing together my arrangement of Mbuga Za Wanyama Tanzania. One of the seven-year-old violin students was conducting our little ensemble, and the whole audience joined in singing and cheering at the end. We were using my battery-operated lantern because the lights were so dim that we could barely see the music, but luckily, I also brought many spare batteries for the stand lights.

    Weekly Friday performances of the programme take place in the Courage Cafe. This cafe is special because it supports women who have been victims of sexual abuse and trafficking. Women who are recovering from these severely challenging circumstances make clothes, bracelets, earrings, and other souvenirs that are sold at the store of this cafe.

    The programme has run for 15 years, and many of the small students have grown and now are in need of the full-size violins. There is a lack of full-size violins, and many students need to play on violins that are a size or two too small. Even though there are many violins donated to the programme, the challenge is how to transport them from the US to Tanzania. I was able to bring three new violins to the programme, generously donated by my student Shwetha Manimaran and her mom, Nivetha. 

    In Tanzania, there are no shops where you can buy violins or strings, and no luthiers. One day, I was checking Makumira College student Fraterin Shayo’s violin to see if it had no open seams and was changing his three-year-old strings to a new set, and I noticed that his bridge was very crooked. I had a brand new spare bridge with me from America, and we decided to put it on. In the process of changing the bridge, the sound post fell down. I had never put in the sound post before that. After watching a YouTube video tutorial and one and a half hours of trying and failing, I managed to put the sound post back in with the tools that the programme luckily had. A few days later, the sound post fell down again. With another hour and a half and a more careful try, I was able to put it back in, and the violin sounded so beautiful with an open and ringing tone. I was extremely relieved that we managed to do it without access to any of the luthiers, and I only ended up with one bloody finger because of pinching it with the sharp edge of the tool. 

    Tanzania is a country to fall in love with and return to, and music is a universal language that can bridge and build international communities. Planting seeds of mpingo trees and planting the seed of education, kindness, and resilience in each and every student, and then watching it grow and flourish.

    There are important lessons to learn from the community of Daraja Music Initiative – in a world full of hatred, conflict, and division, there is something beautiful and more important, which is the future of our planet and children. It’s in our daily steps that we can either build or destroy. With every note we play, with each lesson we teach, and with each tree we plant, we can create a compound and sustainable effort that will make an impact on our future generations.

    All photos courtesy Aija Reke.

    Best of Technique

    In The Best of Technique you’ll discover the top playing tips of the world’s leading string players and teachers. It’s packed full of exercises for students, plus examples from the standard repertoire to show you how to integrate the technique into your playing.

    Masterclass

    In the second volume of The Strad’s Masterclass series, soloists including James Ehnes, Jennifer Koh, Philippe Graffin, Daniel Hope and Arabella Steinbacher give their thoughts on some of the greatest works in the string repertoire. Each has annotated the sheet music with their own bowings, fingerings and comments.

    Calendars

    The Canada Council of the Arts’ Musical Instrument Bank is 40 years old in 2025. This year’s calendar celebrates some its treasures, including four instruments by Antonio Stradivari and priceless works by Montagnana, Gagliano, Pressenda and David Tecchler.

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  • Argentina v England: How tourists can close out series win in San Juan

    Argentina v England: How tourists can close out series win in San Juan

    The strength of England’s bench has been questioned this year. In theory, with 13 players on duty in Australia, it should be under even more pressure.

    However, England finished on the front foot in the first Test, pushing for more points rather than clinging on for victory.

    It is a young set of replacements – six of the eight are 24 or under – and the experience gained at the business end of a Test series in front of a loud, away support will be priceless.

    Borthwick spoke about this tour being a chance to build and reveal Test-match temperament in his youngsters. That focus may be most acute on these finishers.

    Twenty-year-old Asher Opoku-Fordjour, who came under pressure in Sale’s Premiership semi-final defeat by Leicester, will relish the chance to prove himself.

    Chandler Cummingham-South, who is attempting to add second row to his repertoire, needs to rediscover his rampaging best.

    The broken field and tired opposition might suit the all-court skills of Theo Dan, centrally-contracted, but third choice at hooker behind Luke Cowan-Dickie and Jamie George.

    Cadan Murley is exorcising the ghosts of a difficult debut in Dublin, while Jack van Poortvliet, who would have travelled to the last World Cup as England’s first choice scrum-half but for a late injury, is pushing hard to move up the pecking order.

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  • B2-SINE RNAs Boost Nerve Regeneration in Mice

    B2-SINE RNAs Boost Nerve Regeneration in Mice

    Unlike the brain and spinal cord, peripheral nerve cells, whose long extensions reach the skin and internal organs, are capable of regenerating after injury. This is why injuries to the central nervous system are considered irreversible, while damage to peripheral nerves can, in some cases, heal, even if it takes months or years. Despite decades of research, the mechanisms behind peripheral nerve regeneration remain only partially understood. In a new study published in Cell, researchers from Prof. Michael (Mike) Fainzilber’s lab at the Weizmann Institute of Science discovered that a family of hundreds of RNA molecules with no known physiological function is essential to nerve regeneration. Remarkably, the study showed that these molecules can stimulate growth not only in the peripheral nervous system of mice but also in their central nervous system. These findings could pave the way for new treatments for a variety of nerve injuries and neurodegenerative diseases.

    For a peripheral nerve to regenerate, it must maintain communication between the neuron’s cell body and its long extension – the axon – which in humans can reach more than a meter in length. In a series of studies over the past two decades, Fainzilber’s lab has revealed key components of this communication: proteins that act like postal couriers, delivering instructions for the production of growth-controlling factors and other proteins, from the cell body to the axon. These molecular couriers also help assess the distance between the cell body and the axon tip, allowing the neuron to modulate its growth accordingly. Yet one central issue remained: What triggers the regenerative growth after injury, and why does this not happen in central nervous system cells?

    “While the growth acceleration observed in our study is not yet sufficient to address clinical paralysis, it is definitely significant”

    In the new study, Dr. Indrek Koppel of Fainzilber’s lab, in collaboration with Dr. Riki Kawaguchi of the University of California, Los Angeles (UCLA), examined a specific kind of gene expression in the peripheral nerves of mice following injury. The researchers were surprised to find that one day after damage, the neurons increased the expression of an entire family of short genetic sequences called B2-SINEs, whose role was previously unknown. These sequences do not encode any proteins, and because they are known for “jumping” around the genome, meaning that they can appear at the wrong place or time, they have a bad reputation. But the researchers found that after injury, the neurons began expressing many B2-SINE RNA transcripts, in parallel with other processes preparing the cell for regeneration and repair.

    However, B2-SINE is an enormous family, comprising some 150,000 sequences scattered throughout the mouse genome. The initial analysis could not determine which of these were responsible for promoting growth. Dr. Eitan Erez Zahavi, also of Fainzilber’s lab, who led the new study alongside Koppel, used bioinformatics tools to identify 453 B2-SINE sequences that are highly expressed after injury, promoting nerve growth. Collaborating with international research teams, the scientists showed that this overexpression after injury is unique to peripheral nerve cells and does not occur in the central nervous system.

    The periphery leads, the center follows

    The researchers then tested whether B2-SINEs from peripheral nerve cells could also stimulate neuronal growth in the central nervous system. They induced retinal neurons in mice to overexpress RNA molecules of the B2-SINE type and observed faster regeneration after injury. A similar experiment in the mouse motor cortex – the brain region that controls muscle movement via long axons projecting to the spinal cord – showed that neurons expressing high levels of B2-SINE also regenerated faster than control neurons.

    “There are still no effective treatments to accelerate nerve cell growth and regeneration,” Fainzilber notes. “While the growth acceleration observed in our study is not yet sufficient to address clinical paralysis, it is definitely significant. Of course, the path from basic research to clinical application is long, and we must make sure that enhancing growth mechanisms does not, for example, increase the risk of cancer.”

    One final mystery remained: How do B2-SINE RNA molecules actually promote regeneration? With help from Prof. Alma L. Burlingame’s group at the University of California, San Francisco, the researchers discovered that these RNAs promote a physical link between the molecular “couriers” carrying instructions for producing growth-associated proteins and the ribosomes that read these instructions and carry them out. This means that production of the critical factors takes place closer to the cell body rather than to the tip of the axon. The researchers believe that this signals to the neuron that it is “too small,” triggering a growth response.

    “There are over a million sequences called Alu elements in the human genome, the human equivalent of B2-SINEs in mice,” says Fainzilber. “These molecules had been previously shown to bind to ribosomes and mail couriers, but why this happens was unknown. We’re now trying to determine whether Alu or other noncoding RNA elements are involved in nerve regeneration in humans.”

    “Recovery from peripheral nerve injuries, or from systemic diseases like diabetes that affect these nerves, can be very slow,” he adds. “That’s why we’re now testing a therapy that might speed up regeneration by mimicking B2-SINE activity. This therapy involves small molecules that connect the couriers to ribosomes while keeping them close to the nerve cell body, promoting faster growth. We are conducting this research in collaboration with Weizmann’s Bina unit for early-stage research with applicative potential.”

    Beyond promoting peripheral nerve regeneration, the new study also hints at an even broader prospect: regeneration in the central nervous system. “We are currently working with UCLA on a study showing that the mechanism we discovered plays a role in recovery from stroke in mouse models,” Fainzilber says. “Additionally, we’re collaborating with Tel Aviv University, Hebrew University and Sheba Medical Center to study its possible role in ALS, a progressive neurodegenerative disease. Neurodegenerative conditions affect many millions of people worldwide. While the road ahead is long, I truly hope we’ll one day be able to harness our newly discovered regeneration mechanism to treat them.”

    Reference: Zahavi EE, Koppel I, Kawaguchi R, et al. Repeat-element RNAs integrate a neuronal growth circuit. Cell. 2025. doi: 10.1016/j.cell.2025.04.030

    This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source. Our press release publishing policy can be accessed here.

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  • Major airlines suspend flights to middle east amid ongoing safety concerns

    Major airlines suspend flights to middle east amid ongoing safety concerns





    Major airlines suspend flights to middle east amid ongoing safety concerns – Daily Times



































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  • England vs India cricket LIVE: Third Test, day two, Lord’s – scores, radio & highlights

    England vs India cricket LIVE: Third Test, day two, Lord’s – scores, radio & highlights

    Crawley,caught Pant, bowled Nitish

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    Crawley,

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    c Pant

    b Nitish

    18

    43

    37

    4

    0

    67

    41.86

    Duckett,caught Pant, bowled Nitish

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    b Nitish

    Duckett,

    caught Pant, bowled Nitish

    c Pant

    b Nitish

    23

    40

    29

    3

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    64

    57.50

    Pope,caught substitute, bowled Jadeja

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    b Jadeja

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    b Jadeja

    44

    104

    79

    4

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    169

    42.31

    batting,Root,not out

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    batting,

    103

    197

    132

    10

    0

    315

    52.28

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    39

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    124

    37.14

    Extras,

    no balls 2, wides 0, byes 4, leg byes 11, total 17

    Extras,

    no balls 2, wides 0, byes 4, leg byes 11, total 17

    Total,255 for 4

    84.3 overs

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  • Wolves share emotional memorial as Liverpool fans prepare tribute

    Wolves share emotional memorial as Liverpool fans prepare tribute

    Wolves Pay Tribute to Jota in Poignant Molineux Memorial

    Molineux unites in grief and gratitude

    In the heart of Wolverhampton, where memories linger with every blade of grass, Wolves paid a moving tribute to Diogo Jota, a player who once carried their hopes and now leaves behind a legacy far greater than goals alone. The club’s first-team squad and coaching staff made a solemn pilgrimage to Molineux, gathering around the growing memorial at the Billy Wright statue.

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    Footage shared by Wolves captured the emotional moment. Silence enveloped the group as they walked from the team bus, each step measured with reverence. The Portuguese head coach, Vitor Pereira, stood in silent prayer, crossing himself and gripping the metal railing surrounding the floral tributes. His visible emotion mirrored the depth of the collective loss.

    Photo @Wolves on X

    A career remembered in gold and red

    Between 2017 and 2020, Jota made 131 appearances in Wolves colours, scoring 44 goals and playing a pivotal role in their journey from Championship contenders to a confident Premier League outfit. His energy, eye for goal and instinctive link-up play became hallmarks of the club’s attacking identity.

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    In 2020, he crossed over to Anfield, wearing Liverpool red with distinction. His contributions in front of goal, his work ethic and his humility soon made him a fan favourite. Under Arne Slot, Jota won the Premier League and brought the same intensity that had lit up Molineux to the big stage at Anfield.

    Photo: IMAGO

    Liverpool and Wolves share the pain

    The outpouring of emotion has not been confined to the Midlands. Liverpool, too, have been touched by messages, flowers and tributes from across the football community. There have been poignant moments at Anfield, with figures such as David Moyes, Arne Slot, Andy Robertson and Jordan Henderson each paying their respects.

    Photo IMAGO

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    This weekend’s fixture against Preston North End will go ahead, with All Red Video confirming live coverage. A moment of remembrance is expected before kick-off, allowing fans to reflect once more on a man who meant so much to both clubs.

    Jota remembered with dignity and love

    Wolves shared the video with a single line: “Our coaching staff and players remember Diogo.” The sentiment needed no embellishment. The flag above Molineux flew at half-mast, and those who knew the player best paused to honour a man who gave them pride.

    Diogo Jota’s legacy lives in every tribute, every tear and every memory shaped by his brilliance and character.

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  • IEA forecasts slowest oil demand growth since 2009 outside of pandemic – Financial Times

    IEA forecasts slowest oil demand growth since 2009 outside of pandemic – Financial Times

    1. IEA forecasts slowest oil demand growth since 2009 outside of pandemic  Financial Times
    2. Oil Market Report – July 2025 – Analysis  IEA – International Energy Agency
    3. World oil market may be tighter than it looks, IEA says  MSN
    4. IEA boosts 2025 oil supply forecast after latest OPEC+ hike  Yahoo Finance
    5. IEA boosts 2025 oil supply forecast after latest OPEC+ hike By Reuters  Investing.com

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  • Rubio meets China's Wang Yi as trade tensions deepen – Reuters

    1. Rubio meets China’s Wang Yi as trade tensions deepen  Reuters
    2. Rubio says Asia might get ‘better’ tariffs than others  Dawn
    3. Chinese, US top diplomats meet for 1st time in Malaysia  Anadolu Ajansı
    4. US, China set for high-stakes talks at ASEAN Summit  DW
    5. Rubio meets Wang Yi in a first in-person meeting, his second with rival counterparts in 24 hours  Firstpost

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  • EUROPEAN GOLDS AWARDED TO MARTÍNEZ ALMENDROS AND MONCHOIS

    EUROPEAN GOLDS AWARDED TO MARTÍNEZ ALMENDROS AND MONCHOIS

    TIGHT MEN’S FINAL CLOSES WITH MONCHOIS ON TOP

    In the men’s final, Nao Monchois of France pocketed the gold medal with a score of 34+, placing just ahead of Swiss climber Nino Grünenfelder, who had to settle for silver placing just one move behind Monchois at 33+. Another French athlete, Younès Aubert Masmoudi, took bronze, also climbing just one hold less than the athlete ahead o him – 32+.

    For the men’s Lead complete results click here.

    NEXT UP

    The next European Cup is scheduled to take place in St. Pölten, Austria, on 17 August, featuring a Speed competition and being held alongside a Youth European Cup, also in Speed.

    News and updates about all IFSC events will be available on the IFSC website and on the Federation’s digital channels: Facebook, Instagram, LinkedIn, Threads, TikTok, X, YouTube, and exclusively for the Chinese audience, Douyin, Weibo, and Xiaohongshu.


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