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  • Indian women’s cricket team loses final match of England series

    Indian women’s cricket team loses final match of England series

    The Indian women’s cricket team lost to England by five wickets in the fifth and final game of the ENG-W vs IND-W T20 2025 series at Edgbaston, Birmingham, on Saturday.

    Despite the loss, India will head back home with a 3-2 series win, having come into the final game with an unassailable 3-1 lead. This also caps off India’s first-ever bilateral T20 series win against England in women’s cricket history.

    They had lost all six of their previous multi-game bilateral series’ in the format against the English. India did win a one-off T20 against England at Derby back in 2006, which was also the first-ever meeting between the two teams in the format.

    The match also saw Indian T20 captain Harmapreet Kaur play her 334th international match for India, taking her past former skipper Mithali Raj as the most-capped Indian woman in cricket history.

    Sent in to bat first by the hosts, India lost opener Smriti Mandhana and Jemimah Rodrigues early with the scoreboard reading 19/2 midway through the third over.

    However, Shafali Verma and Harmanpreet Kaur steadied the ship with a 66-run stand for the third wicket before the Indian captain’s stumps were rattled by Charlie Dean.

    Shafali, meanwhile, scored her 11th T20I half-century in just 23 balls, making it the second-quickest ever in the format by any Indian on the heels of Richa Ghosh’s 18-ball fifty against the West Indies last year.

    Dean played spoilsport again as she dismissed the Indian opener for 75 after Maia Bouchier took a brilliant catch in the deep to affect the dismissal.

    Shafali’s exit derailed the Indian innings for a bit but cameos by Richa (20 off 14), Radha Yadav (14* off 14) and Arundhati Reddy (9* off 5) saw India post a very credible 167/7 in their 20 overs.

    England openers Sophia Dunkley and Danni Wyatt-Hodge got the hosts’ chase to a flying start and put up 57/0 on the board in the powerplay overs.

    Wyatt-Hodge, making her 300th international appearance for England, raced to her 21st T20I fifty in just 32 deliveries.

    Radha Yadav gave India the breakthrough in the 11th over after castling Dunkley four short of her fifty. England were at 101/1 at the time.

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  • Protein Intake Shields Against Muscle Loss on Anti-Obesity Drug

    Protein Intake Shields Against Muscle Loss on Anti-Obesity Drug

    SAN FRANCISCO—Women and older adults taking the anti-obesity drug semaglutide may be at higher risk for muscle loss, but higher protein intake may help prevent muscle loss in these patients, according to a small study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.

    Losing muscle (or lean mass) is a common side effect of weight loss in adults with obesity and may negatively affect metabolism and bone health. This is because muscle helps control blood sugar after meals and plays an important role in keeping bones strong, according to study lead researcher Melanie Haines, M.D., of Massachusetts General Hospital and Harvard Medical School in Boston, Mass.

    Approximately 40% of the weight lost from taking semaglutide—a type of weight-loss medication known as a GLP-1—comes from lean mass, including muscle. It is not yet known who is at highest risk for muscle loss or how it affects blood sugar levels, Haines said.

    The researchers studied 40 adults with obesity for three months. Of these patients, 23 were prescribed semaglutide, while 17 followed a diet and lifestyle program for weight loss called Healthy Habits for Life (HHL). The researchers evaluated how their muscle mass changed.

    Study participants who were prescribed semaglutide lost more weight than those who participated in the diet and lifestyle program, but the percent of weight loss that was lean mass was similar between the two groups.

    After accounting for weight loss, the researchers found that in the semaglutide group, being older, female or eating less protein was linked to greater muscle loss. Also in this group, losing more muscle was linked to less improvement in blood sugar (HbA1c levels).

    “Older adults and women may be more likely to lose muscle on semaglutide, but eating more protein may help protect against this,” Haines said. “Losing too much muscle may reduce the benefits of semaglutide on blood sugar control. This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity.”

    Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications.

    /Public Release. This material from the originating organization/author(s) might be of the point-in-time nature, and edited for clarity, style and length. Mirage.News does not take institutional positions or sides, and all views, positions, and conclusions expressed herein are solely those of the author(s).View in full here.

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  • How on-screen portrayals of mental illness have changed since One Flew Over the Cuckoo’s Nest : NPR

    How on-screen portrayals of mental illness have changed since One Flew Over the Cuckoo’s Nest : NPR

    As the Academy Award-winning film One Flew Over the Cuckoo’s Nest marks its 50th anniversary, on-screen portrayals of mental illness and treatment have evolved.



    SCOTT DETROW, HOST:

    Nearly 50 years ago, theatergoers were introduced to Milos Forman’s film “One Flew Over The Cuckoo’s Nest.” It was based on Ken Kesey’s best-selling novel, and it starred Jack Nicholson as a new patient at a state psychiatric hospital.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    JACK NICHOLSON: (As Randle Patrick McMurphy) If that’s what being crazy is, then I’m senseless, out-of-it, gone-down-the-road wacko.

    DETROW: “One Flew Over The Cuckoo’s Nest” won multiple Oscars, including best picture, at the 1976 Academy Awards. As NPR’s Mandalit del Barco reports, a restored version will be screening at theaters tomorrow and on Wednesday, July 16.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    NICHOLSON: (As Randle Patrick McMurphy, laughter) Whoo. Hoo-hoo-hoo (ph).

    MANDALIT DEL BARCO, BYLINE: In “One Flew Over The Cuckoo’s Nest,” Jack Nicholson’s character, R.P. McMurphy, has been convicted of rape, but he avoids time on a prison work farm by faking mental illness. He’s portrayed as a charismatic rebel, butting heads with the controlling Nurse Ratched, and he inspires a rebellion by the other patients who, unlike him, are in the institution voluntarily.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    NICHOLSON: (As Randle Patrick McMurphy) How about it, you creeps, you lunatics, mental defectives?

    DEL BARCO: Actor Danny DeVito played a patient named Martini.

    DANNY DEVITO: Real harmless, really sweet guy.

    DEL BARCO: DeVito first played the character in an off-Broadway production. He says to prepare for that role, he and the stage cast visited the state-run psychiatric institution on Wards Island in New York. The film was shot on location at a mental health facility in Salem, Oregon. And he says the casting was perfect.

    DEVITO: They found this guy to play McMurphy – ha, ha, ha – this brilliant guy, Jack Nicholson. He was, like, just a trip, man. He was, like, the best.

    DEL BARCO: In the film, Nicholson’s character is held down to undergo electroshock therapy.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    UNIDENTIFIED ACTOR #1: (As character) Here we go.

    (SOUNDBITE OF ELECTRICITY)

    NICHOLSON: (As Randle Patrick McMurphy, groaning).

    DEL BARCO: He ends up with a lobotomy.

    KEN DUCKWORTH: The meta message that you could be punished, lobotomized, held down against your will isn’t a great message for help-seeking in terms of the mental health field.

    DEL BARCO: Ken Duckworth is a psychiatrist and the chief medical officer for the National Alliance on Mental Illness. He remembers seeing “One Flew Over The Cuckoo’s Nest” at a theater in 1975 when he was 17.

    DUCKWORTH: And believe it or not, my father was in and out of a state hospital for very bad bipolar disorder. When I visited him, the industrial, institutional coldness of it all felt familiar to me in the film.

    DEL BARCO: Duckworth says it’s a brilliant film with kernels of truth about the overcrowded institutions of the 1960s, when the story was set. But he says it left a lasting impression.

    DUCKWORTH: You talk to somebody with major depression. They’d be on multiple meds. You say, were you ever exposed to electroconvulsive therapy or shock therapy? Oh, no. I saw what happened to Jack Nicholson. I’m not letting them do that.

    (SOUNDBITE OF FILM, “THE SNAKE PIT”)

    UNIDENTIFIED ACTOR #2: (As character) Don’t be afraid, Mrs. Cunningham.

    DEL BARCO: Before “Cuckoo’s Nest,” the 1948 film “The Snake Pit” was set in a psych ward. Olivia de Havilland earned an Oscar nomination for portraying a woman who has a nervous breakdown and undergoes shock therapy.

    (SOUNDBITE OF FILM, “THE SNAKE PIT”)

    OLIVIA DE HAVILLAND: (As Virginia Cunningham, groaning).

    DEL BARCO: These days, electroconvulsive therapy happens under anesthesia, lobotomies are almost never performed and patients are no longer being warehoused in large mental institutions. Duckworth says, increasingly, films and TV shows offer more humanistic and empathetic portrayals.

    (SOUNDBITE OF FILM, “SILVER LININGS PLAYBOOK”)

    BRADLEY COOPER: (As Patrizio Solitano) I used to be on lithium and Seroquel and Abilify, but I don’t take them anymore, no.

    DEL BARCO: In the 2012 film “Silver Linings Playbook,” Bradley Cooper’s and Jennifer Lawrence’s characters compare meds.

    (SOUNDBITE OF FILM, “SILVER LININGS PLAYBOOK”)

    COOPER: (As Patrizio Solitano) You ever take Klonopin?

    JENNIFER LAWRENCE: (As Tiffany Maxwell) Klonopin? Yeah.

    COOPER: (As Patrizio Solitano) Right?

    LAWRENCE: (As Tiffany Maxwell) Jesus.

    COOPER: (As Patrizio Solitano) Like, I said what?

    LAWRENCE: (As Tiffany Maxwell) Yeah (laughter).

    COOPER: (As Patrizio Solitano) What day is it?

    DEL BARCO: Series like “Shrinking” feature caring therapists with their own vulnerabilities. And even “The Sopranos” showed everyone could use talk therapy, says DeVito.

    DEVITO: Yeah. Like, Tony Soprano’s not going to lay down for a lobotomy, right? Nah.

    DEL BARCO: Like that HBO classic, “One Flew Over The Cuckoo’s Nest” remains a cultural touchstone. Mandalit del Barco, NPR News.

    Copyright © 2025 NPR. All rights reserved. Visit our website terms of use and permissions pages at www.npr.org for further information.

    Accuracy and availability of NPR transcripts may vary. Transcript text may be revised to correct errors or match updates to audio. Audio on npr.org may be edited after its original broadcast or publication. The authoritative record of NPR’s programming is the audio record.

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  • How on-screen portrayals of mental illness have changed since One Flew Over the Cuckoo’s Nest

    SCOTT DETROW, HOST:

    Nearly 50 years ago, theatergoers were introduced to Milos Forman’s film “One Flew Over The Cuckoo’s Nest.” It was based on Ken Kesey’s best-selling novel, and it starred Jack Nicholson as a new patient at a state psychiatric hospital.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    JACK NICHOLSON: (As Randle Patrick McMurphy) If that’s what being crazy is, then I’m senseless, out-of-it, gone-down-the-road wacko.

    DETROW: “One Flew Over The Cuckoo’s Nest” won multiple Oscars, including best picture, at the 1976 Academy Awards. As NPR’s Mandalit del Barco reports, a restored version will be screening at theaters tomorrow and on Wednesday, July 16.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    NICHOLSON: (As Randle Patrick McMurphy, laughter) Whoo. Hoo-hoo-hoo (ph).

    MANDALIT DEL BARCO, BYLINE: In “One Flew Over The Cuckoo’s Nest,” Jack Nicholson’s character, R.P. McMurphy, has been convicted of rape, but he avoids time on a prison work farm by faking mental illness. He’s portrayed as a charismatic rebel, butting heads with the controlling Nurse Ratched, and he inspires a rebellion by the other patients who, unlike him, are in the institution voluntarily.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    NICHOLSON: (As Randle Patrick McMurphy) How about it, you creeps, you lunatics, mental defectives?

    DEL BARCO: Actor Danny DeVito played a patient named Martini.

    DANNY DEVITO: Real harmless, really sweet guy.

    DEL BARCO: DeVito first played the character in an off-Broadway production. He says to prepare for that role, he and the stage cast visited the state-run psychiatric institution on Wards Island in New York. The film was shot on location at a mental health facility in Salem, Oregon. And he says the casting was perfect.

    DEVITO: They found this guy to play McMurphy – ha, ha, ha – this brilliant guy, Jack Nicholson. He was, like, just a trip, man. He was, like, the best.

    DEL BARCO: In the film, Nicholson’s character is held down to undergo electroshock therapy.

    (SOUNDBITE OF FILM, “ONE FLEW OVER THE CUCKOO’S NEST”)

    UNIDENTIFIED ACTOR #1: (As character) Here we go.

    (SOUNDBITE OF ELECTRICITY)

    NICHOLSON: (As Randle Patrick McMurphy, groaning).

    DEL BARCO: He ends up with a lobotomy.

    KEN DUCKWORTH: The meta message that you could be punished, lobotomized, held down against your will isn’t a great message for help-seeking in terms of the mental health field.

    DEL BARCO: Ken Duckworth is a psychiatrist and the chief medical officer for the National Alliance on Mental Illness. He remembers seeing “One Flew Over The Cuckoo’s Nest” at a theater in 1975 when he was 17.

    DUCKWORTH: And believe it or not, my father was in and out of a state hospital for very bad bipolar disorder. When I visited him, the industrial, institutional coldness of it all felt familiar to me in the film.

    DEL BARCO: Duckworth says it’s a brilliant film with kernels of truth about the overcrowded institutions of the 1960s, when the story was set. But he says it left a lasting impression.

    DUCKWORTH: You talk to somebody with major depression. They’d be on multiple meds. You say, were you ever exposed to electroconvulsive therapy or shock therapy? Oh, no. I saw what happened to Jack Nicholson. I’m not letting them do that.

    (SOUNDBITE OF FILM, “THE SNAKE PIT”)

    UNIDENTIFIED ACTOR #2: (As character) Don’t be afraid, Mrs. Cunningham.

    DEL BARCO: Before “Cuckoo’s Nest,” the 1948 film “The Snake Pit” was set in a psych ward. Olivia de Havilland earned an Oscar nomination for portraying a woman who has a nervous breakdown and undergoes shock therapy.

    (SOUNDBITE OF FILM, “THE SNAKE PIT”)

    OLIVIA DE HAVILLAND: (As Virginia Cunningham, groaning).

    DEL BARCO: These days, electroconvulsive therapy happens under anesthesia, lobotomies are almost never performed and patients are no longer being warehoused in large mental institutions. Duckworth says, increasingly, films and TV shows offer more humanistic and empathetic portrayals.

    (SOUNDBITE OF FILM, “SILVER LININGS PLAYBOOK”)

    BRADLEY COOPER: (As Patrizio Solitano) I used to be on lithium and Seroquel and Abilify, but I don’t take them anymore, no.

    DEL BARCO: In the 2012 film “Silver Linings Playbook,” Bradley Cooper’s and Jennifer Lawrence’s characters compare meds.

    (SOUNDBITE OF FILM, “SILVER LININGS PLAYBOOK”)

    COOPER: (As Patrizio Solitano) You ever take Klonopin?

    JENNIFER LAWRENCE: (As Tiffany Maxwell) Klonopin? Yeah.

    COOPER: (As Patrizio Solitano) Right?

    LAWRENCE: (As Tiffany Maxwell) Jesus.

    COOPER: (As Patrizio Solitano) Like, I said what?

    LAWRENCE: (As Tiffany Maxwell) Yeah (laughter).

    COOPER: (As Patrizio Solitano) What day is it?

    DEL BARCO: Series like “Shrinking” feature caring therapists with their own vulnerabilities. And even “The Sopranos” showed everyone could use talk therapy, says DeVito.

    DEVITO: Yeah. Like, Tony Soprano’s not going to lay down for a lobotomy, right? Nah.

    DEL BARCO: Like that HBO classic, “One Flew Over The Cuckoo’s Nest” remains a cultural touchstone. Mandalit del Barco, NPR News. Transcript provided by NPR, Copyright NPR.

    NPR transcripts are created on a rush deadline by an NPR contractor. This text may not be in its final form and may be updated or revised in the future. Accuracy and availability may vary. The authoritative record of NPR’s programming is the audio record.


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  • Hubble Images Used to Create a Beautiful Portrait of the Abell 209 Galaxy Cluster

    Hubble Images Used to Create a Beautiful Portrait of the Abell 209 Galaxy Cluster

    The Hubble Space Telescope continues to observe the cosmos and deliver some of the most breathtaking views of astronomical objects ever taken. The telescope recently imaged Abell 209, a galaxy cluster located 2.8 billion light years away in the constellation Cetus. The picture was selected as the NASA/ESA Hubble Space Telescope Picture of the Week, as it beautifully illustrates the galaxies that constitute it and the lensing effect it has surrounding space. The galaxies appear as brightly shining points in the image, emitting light that appears to take an oval shape, crowded around a particularly massive one.

    The image also shows several similarly sized spiral galaxies that appear blueish and have various shapes. Other smaller, more distant galaxies can be seen around the cluster’s edges and the brightest galaxy in the center-right. These appear warped and elongated by the gravitational lensing effect produced by the cluster. But there’s far more to observe in this cluster than even the venerable Hubble can see. For example, while the cluster contains over 100 galaxies separated by millions of light-years, the space between is filled with hot, diffuse gas that can only be seen in X-ray wavelengths.

    There’s also the unseen mass that permeates this cluster and accounts for roughly 80% of the Universe’s mass: the elusive Dark Matter. This mass does not interact with normal, “luminous” matter (i.e., in visible light), and can only be inferred from the gravitational interactions in and around the cluster. Its influence can also be gauged based on how much it warps spacetime, distorting and amplifying light from more distant objects (aka, gravitational lenses). This makes observations of large-scale cosmic structures useful to astronomers because they can provide insight into the fundamental mysteries of the cosmos.

    The Hubble Space Telescope has helped astronomers to chart the evolution of the cosmos. Credit: NASA

    This includes Dark Matter and Dark Energy, which account for 25% and 70% of the mass-energy density of the Universe (respectively). Gravitational lenses allow astronomers to map the matter distribution of galaxies and clusters, leading them to constrain the influence of Dark Matter. They also allow astronomers to peer deeper into the cosmos, allowing for distance measurements that can help them measure the rate of cosmic expansion (the Hubble Constant) and the influence of Dark Matter.

    Furthermore, these clusters and their gravitational lenses are an effective means of testing Einstein’s Theory of General Relativity and other theories of how our Universe evolved. In this respect, Hubble continues to live up to its legacy and is still helping astronomers explore the deeper mysteries of the cosmos.

    Further Reading: ESA

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  • Australia make steady progress to tea in day/night third Test against West Indies – France 24

    1. Australia make steady progress to tea in day/night third Test against West Indies  France 24
    2. West Indies vs Australia, 3rd Test  Cricbuzz.com
    3. Lyon, Braithwaite dropped for Jamaica day-night Test  ESPNcricinfo
    4. Follow live updates from Sri Lanka vs Bangladesh  The Independent
    5. Why is Nathan Lyon not playing in third Test against West Indies?  India TV News

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  • Australia make steady progress to tea in day/night third Test against West Indies – France 24

    1. Australia make steady progress to tea in day/night third Test against West Indies  France 24
    2. West Indies vs Australia, 3rd Test  Cricbuzz.com
    3. Lyon, Braithwaite dropped for Jamaica day-night Test  ESPNcricinfo
    4. Follow live updates from Sri Lanka vs Bangladesh  The Independent
    5. Why is Nathan Lyon not playing in third Test against West Indies?  India TV News

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  • Google Contacts adds ‘Recent activity’ with messages, calls

    Google Contacts adds ‘Recent activity’ with messages, calls

    One of the most useful aspects of Pixel VIPs is how it shows recent calls and messages, and the Google Contacts app is now gaining that functionality with “Recent activity.”

    Recent activity is a new card in-between Contact info and Connected apps. It shows the most recent call and message from the contact you’re viewing. The former notes when it occurred and duration, or if you missed the call.

    You can also see the last sent text/chat in Google Messages, with Contacts also noting what number was used. A tap opens the conversation directly.

    Recent activity might already be populated with call information, but you have to enable the SMS permission to “view messages from your contacts.” A prompt guides you through that process.

    Advertisement – scroll for more content

    This can also be accessed through the Google Phone app (though access to Contacts is being deprioritized), and builds on how the homescreen widget can show notifications.

    This functionality matches Pixel VIPs. Personally, I’ve been using the widget to immediately get into conversations. It speaks to how a dedicated Google Messages widget might be useful. 

    We’re seeing this live with version 4.58 of Google Contacts. It has been rolling out in the past week or so, but is now seeing wider availability.

    Thanks Tushar

    FTC: We use income earning auto affiliate links. More.

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  • Towards a Muscarinic Agent Solution for the Presynaptic Dopamine Problem in Schizophrenia

    Towards a Muscarinic Agent Solution for the Presynaptic Dopamine Problem in Schizophrenia

    CONFERENCE REPORTER

    “It’s new medicine, brand new mechanism, which is very distinct from what we have for the past 70 years,” Jonathan Meyer, MD said of new xanomeline-trospium (X-T) treatment for schizophrenia. Moving away from traditional dopamine blocking mechanisms, new treatments for schizophrenia pivot to target cholinergic pathways with muscarinic agents. Muscarinic agents may be a solution to the issue of excess dopamine in the presynapse, with X-T showing improvement of positive schizophrenia symptoms and no side effects of tardive dyskinesia like traditional prescriptions.

    Gus Alva, MD, Jonathan Meyer, MD, and Chelsie Monroe, APN, presented these latest findings in schizophrenia medication in their session “Visualizing the Role of Novel Muscarinic Agents in the Management of Schizophrenia” at the 2025 Southern California Psychiatry Conference.1

    The long-held belief that positive symptoms of schizophrenia result from excess dopamine in the mesolimbic pathway has recently been questioned, with human models suggesting the issue may actually lie in presynaptic dopamine release specifically in the striatum. Clinicians have managed positive symptoms by using D2 antagonists for decades, but with new drug developments that can adjust presynaptic activity—rather than react to change postsynaptic activity—positive symptoms can be better managed.2

    In this session, presenters detailed a promising alternative to D2 antagonists: targeting the muscarinic acetylcholine receptors (focused on M1 and M4) as a way to regulate dopamine release presynaptically without blocking dopamine receptors directly. This new investigational therapy combines xanomeline, a selective M1 and M4 agonist, with trospium, a peripheral anticholinergic that avoids unwanted side effects by limiting activity outside the central nervous system.

    The unique action of xanomeline-trospium modulates neurotransmitter pathways upstream of dopamine, thereby avoiding the motor and endocrine side effects commonly seen with D2 antagonists. M1 receptor activation reduces dopamine indirectly through GABA and glutamate signaling, while M4 agonism acts from the lower level, modulating acetylcholine production in the ventral tegmental area. This mechanism allows for much stronger safety profiles because there is not a potential for major motor issues like tardive dyskinesia many patients can suffer from with traditional D2 antagonists.

    Data showed significant reductions in Positive and Negative Syndrome Scale (PANSS) scores, with patients seeing average declines of 33.6 points by week 52. Most notably, there were no cases of tardive dyskinesia, and the most common side effects were brief and manageable cholinergic issues. Dr. Alva noted that X-T may be particularly beneficial for chronic schizophrenia patients who have not responded well to traditional treatments. While currently approved by the FDA as a monotherapy, discussions and research are ongoing about X-T’s potential use alongside other antipsychotics.

    However, this new medication comes with important practical considerations for prescribers. X-T must be taken one hour before or two hours after a meal, as taking it with food reduces trospium absorption by up to 90%. If a patient has issues with nausea due to being unable to take X-T with food, extra trospium can be added to their regimen to reduce these side effects. Starting X-T also involves titration to mitigate cholinergic side effects like urinary or bowel issues caused by trospium. Patients who are already on other antipsychotic medications also may need a closely watched cross titration process, as many traditional medications have anticholinergic properties that can interfere with X-T.

    With this new muscarinic focused approach, there is less focus on reacting to downstream, postsynaptic effects of excess dopamine, and instead X-T alters presynaptic dopamine. The FDA approval of xanomeline-trospium introduces a new chapter in schizophrenia treatment, offering long awaited relief from motor symptoms of traditional antipsychotics and lessening positive psychotic symptoms.

    References

    1. Alva G, Meyer J, Monroe C. Visualizing the Role of Novel Muscarinic Agents in the Management of Schizophrenia. Conference Proceedings of the Southern California Psychiatry Conference. July 2025;11-12. Huntington Beach, CA.

    2. Kaul I, Sawchak S, Claxton A. et al. Efficacy of xanomeline and trospium chloride in schizophrenia: pooled results from three 5-week, randomized, double-blind, placebo-controlled, EMERGENT trials. Schizophr. 2024;10:102.

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  • Emotional health of parents tied to well-being of children with growth hormone deficiency

    Emotional health of parents tied to well-being of children with growth hormone deficiency

    Strong emotional links between children with chronic conditions and their family caregivers suggest that improving parent well-being may directly benefit a child’s overall health and coping mechanisms, according to a study being presented Saturday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. 

    The study observed children with growth hormone deficiency and their caregivers to better understand the impact that physical or emotional distress can have. Findings suggest that when parents or caregivers of children with growth hormone deficiency report symptoms of stress, anxiety and depression, so does the child they are caring for. Conversely, when caregivers exuded hope and emotional stability, children with growth hormone deficiency were better able to cope with their condition and showed improved overall health.

    “We’ve long recognized the stress caregivers face, but our study shows just how intertwined parent and child health really are,” said Luis Fernandez Luque, Ph.D., chief scientific officer and co-founder of Adhera Health in Santa Cruz, Calif., which developed the digital companion platform used by the caregivers in the study. “Supporting the caregiver isn’t just helpful—it is essential to improving outcomes for children with growth hormone deficiency or other chronic pediatric conditions.”

    The study followed 50 caregivers of children with growth hormone deficiency over a three-month period during participation in Adhera Health’s digital health program focused on caregiver wellbeing. Caregivers completed a series of validated assessments measuring their own emotional and mental health and reported on the child’s physical and emotional status.

    Findings indicated that a children’s emotional and physical health are strongly correlated with caregiver well-being. Greater child distress, such as negative feelings about treatment or difficulty coping with growth hormone deficiency, was associated with higher caregiver stress, anxiety and depressive symptoms. In addition, caregiver hopefulness about the future was linked to better emotional outcomes in the child.

    “This research confirms the well-being of children with chronic conditions is inseparable from the emotional health of their caregivers,” said Ricardo C. Berrios, CEO and co-founder of Adhera Health, who was a co-author of the study. “Adhera’s AI-powered platform was designed from the ground up to support this dynamic, combining behavioral science and responsible AI to empower families—not just patients. These findings strengthen our conviction that improving outcomes for children requires an ecosystem approach, one that puts caregivers at the center of pediatric chronic care.”

    The study was supported by Merck KGaA in Darmstadt, Germany.

    About Endocrine Society
    Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

    The Society has more than 18,000 members, including scientists, physicians, educators, nurses, and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at www.endocrine.org. Follow us on X (formerly Twitter) at @TheEndoSociety and @EndoMedia.


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