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  • Dementia Linked With Treatment For Chronic Lower Back Pain : ScienceAlert

    Dementia Linked With Treatment For Chronic Lower Back Pain : ScienceAlert

    A drug widely used to treat nerve pain and epilepsy has been linked with an increase in cases of dementia and mild cognitive impairment.

    A team from Case Western Reserve University School of Medicine, Arizona State University, and the MetroHealth Medical Center in the US crunched the numbers on 26,416 records of patients with chronic lower back pain, looking at the relationship between prescriptions for the anticonvulsant gabapentin and dementia diagnoses.

    Having six or more gabapentin prescriptions was linked to a significant increase in dementia risk and mild cognitive impairment (MCI), the data showed: those in that group were 29 percent and 85 percent more likely to be diagnosed with dementia and MCI respectively, within 10 years.

    Related: Massive Study Links 15 Factors to Early Dementia Risk

    The increase was higher among patients aged between 35 and 49, and also rose with the number of prescriptions given, the researchers found. Though the study can’t establish a cause for the increase, physicians are encouraged to keep a close eye on patients taking the drug.

    “Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults,” write the researchers in their published paper.

    “Physicians should monitor cognitive outcomes in patients prescribed gabapentin.”

    Sold under brand names including Neurontin, gabapentin has proved to be less addictive than opioids, making it more likely to be prescribed in recent years. The drug does have some known side effects though, including extreme moods and allergic reactions.

    This isn’t the first time researchers have examined associations between gabapentin and dementia, but previous studies haven’t agreed on whether or not concerns are warranted.

    Gabapentin is a commonly prescribed medication for pain relief and epilepsy. (Gabapentin by Dominic Milton Trott, CC BY 2.0)

    One of the study’s strengths is the relatively large sample size of its participants, though the sample largely consisted of just one group of people – those with chronic lower back pain. A study published in 1997 found no link between gabapentin and cognitive decline in people with epilepsy, so it’s important to continue to widen the data set.

    These conflicting results could suggest unique mechanisms among patients with the type of backpain that leads to a gabapentin prescription that also increases their risk of dementia, like a certain type of location of inflammation.

    But gabapentin works by dampening some of the brain’s key communication channels, in order to provide relief from pain or make seizures less likely. So the worry is that it could also be damaging links between neurons in ways that might lead to dementia – a concern backed up by this latest study.

    Dementia is a challenging condition to study with so many potential factors to account for, but each study gets us closer to the full picture of how the brain breaks down over time.

    “We hope the current study promotes further research to delineate whether gabapentin plays a causal role in the development of dementia and the underlying mechanisms of this relationship,” write the researchers.

    The research has been published in Regional Anesthesia & Pain Medicine.

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  • Here’s How to Watch : ScienceAlert

    Here’s How to Watch : ScienceAlert

    One of the best meteor showers of the year is almost here! The Perseids peak in mid-August, and should put on a decent show.

    The Perseids meteor shower arrives every year between July and September, as Earth swings into the debris trail of the comet 109P/Swift-Tuttle. It’s one of the most popular events on the skywatching calendar, thanks to the frequency of meteors visible and their tendency to burn brighter and longer than those in many other showers.

    The fact that it’s summer in the Northern Hemisphere, where they’re most visible, probably helps draw crowds beneath the cool night sky.

    In dark conditions, Perseids can appear to be particularly prolific, with 50 to 75 visible meteors per hour at their peak. And they’re quick, zipping by at up to 59 kilometers (37 miles) per second.

    Related: Three Epic Meteor Showers Are About to Light Up July – Here’s Your Guide

    This year, the shower will be visible from July 17 to August 23, peaking in the early hours of August 13.

    Sadly, the Moon is being a bit of a glory hog this time around, being 84 percent full on the peak night. That extra light will wash out the fainter meteors, leaving only the brightest to shine through and reducing the visible activity to about 25 meteors per hour.

    (Jbout/Wikimedia commons/CC0-1.0)

    Even so, it’s well worth the effort. Not only is that still more meteors than some other showers, but they’ll be only the best and brightest the Perseids have to offer.

    For best results, get yourself out to a nice, dark spot away from city lights in the hours before dawn. Look to the northeast, towards the constellation of Perseus – the shower’s namesake – which is where the meteors will appear to be radiating from. Avoid using your phone, to give your eyes time to adjust to the dark. Then, bust out the popcorn.

    If you miss the Perseids, don’t worry. There are still plenty of other meteor showers to see out the year.

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  • Air India crash probe focuses on actions of plane's captain, WSJ reports – Reuters

    1. Air India crash probe focuses on actions of plane’s captain, WSJ reports  Reuters
    2. Exclusive | New Details in Air India Crash Probe Shift Focus to Senior Pilot  The Wall Street Journal
    3. How Air India flight 171 crashed and its fatal last moments  Al Jazeera
    4. India orders its airlines to check fuel switches on Boeing jets  Dawn
    5. Doomed Air India pilot’s medical records probed amid reports of depression, other mental health struggles  New York Post

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  • Govt offloads another white elephant

    Govt offloads another white elephant

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    ISLAMABAD:

    The government on Wednesday reaffirmed its decision to close the lossmaking Utility Stores Corporation from the end of this month and constituted a panel to consider giving a golden handshake to 11,421 employees that may cost it over Rs29 billion.

    It was not clear whether the government would give the severance package to all 11,421 employees or limit it to regular 5,217 employees. The discussions took place during a meeting of a committee constituted by the Prime Minister to oversee the closure and privatization of the Utility Stores Corporation (USC).

    Finance Minister Muhammad Aurangzeb chaired the meeting, which was attended by other cabinet members.

    The committee has been tasked with ensuring a smooth and transparent closure process, formulating a suitable VSS for USC employees, and recommending a structured timeline for privatisation, said the Ministry of Finance.

    The finance ministry said that the committee reviewed the progress made in the light of the tasks assigned to it and held detailed deliberations on the way forward.

    “It was reaffirmed that, in accordance with the government’s directives, all operations of USC will be closed by July 31, 2025,” according to the Ministry of Finance. The committee discussed at length the formulation of a fair and financially viable Voluntary Separation Scheme (VSS) for the USC employees, it added.

    Trading entities like USC struggled with high liabilities, ineffective subsidy utilisation, and operational inefficiencies, according to the SOEs performance report that the Ministry of Finance released last week. It added that dependence on delayed government subsidies creates cash flow crisis, while poor inventory management worsens fiscal risks

    The Finance Ministry report stated that the USC lost Rs6.1 billion at the operating level during July-December period of last fiscal year and it was riddled with finance costs, adding to the burden due to compounding operational losses.

    The USC model is subsidy-driven rather than market and cumulative losses stood at Rs15.9 billion as of December last year, according to the Finance Ministry. It added that the balance sheet revealed a weak equity of just Rs1.8 billion, heavily overshadowed by current liabilities of Rs50.7 billion, reflecting solvency risks and negative working capital.

    According to the official documents, there were a total 11,421 employees of the USC, including 5,217 regular employees. The total cost of the golden handshake is estimated at Rs29.2 billion, including Rs22.8 billion for the regular employees. However, these figures are not final and the cost of the severance package will be determined by another committee.

    The details showed that the regular employees having over 20 years association with the USC would get two running basic pays of the completed years while those having less than 20 years of experience will get either three running basic pay of completed years or 125% of the basic pay of the remaining months, whichever is higher.

    The regular employees will also get terminal dues and house rents.

    There are 3,319 contractual employees who are proposed to receive two running basic pay of completed years as compensation, which will cost Rs3.5 billion. Another 2,885 are the daily wagers who are proposed to be given two salaries of the completed years that will cost Rs2.9 billion.

    The entity has 21 properties and it also faces a major issue of non-payments of promised subsidies of over Rs50 billion by the Ministry of Finance.

    The Finance Ministry handout stated that during the course of the meeting, the members examined various dimensions of the proposed VSS, including its projected size, potential fiscal impact, and legal and operational implications associated with its structure and rollout. The Committee recommended that the Privatization Commission be consulted regarding the optimal structuring and feasibility of privatization or alternatively asset sales linked with the USC operations.

    To facilitate a comprehensive analysis, the Chair constituted a sub-committee headed by the Secretary Establishment Division, stated the ministry.

    The committee will include representatives from the Finance Division and the Industries & Production Division to examine the legal and operational aspects, contours, size, and structure of the proposed VSS and submit its report to the main Committee by the end of the week.

    This will enable the Committee to consolidate its findings and finalize its report and recommendations to be submitted to the Prime Minister in line with the Terms of Reference, said the Ministry of Finance.

    The SOEs report stated that USC’s heavy reliance on government subsidies and declining sales highlighted systemic inefficiencies. The USC reflects a structurally weak and inefficient business model that is unsustainable without continuous government subsidies.

    The report showed that the company’s sales sharply dropped by more than 50% compared to the same period last year — showing the company’s inability to retain market share or operate competitively. However, one of the reasons for drop in sales was the government’s decision to wind up the entity.

    The report underlined that without structural reform, including privatization, supply chain digitization, direct beneficiary targeting (DBT) of subsidies, and converting to a lean wholesale model, USC will continue draining fiscal resources with no viable path to self-sustainability.

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  • Changes On Cricket’s Chief Executives’ Committee After Election Kick-Starts ICC Annual Conference

    Changes On Cricket’s Chief Executives’ Committee After Election Kick-Starts ICC Annual Conference

    Gurumurthy Palani (France), Anuraag Bhatnagar (Hong Kong) and Gurdeep Klair (Canada) won coveted spots on the Chief Executives’ Committee after Thursday’s election kick-started the International Cricket Council’s annual conference in Singapore.

    Three coveted Associate Member seats were up for grabs amid changing dynamics among cricket’s powerbrokers. Palani and Bhatnagar finished with 28 votes, while Klair had 21.

    The results mean the influential CEC will be new-look after Sumod Damodar, a veteran administrator and former chair of the African Cricket Association, did not retain his position after finishing with 16 votes.

    Damodar was the only incumbent to recontest in the eight-candidate field, with Rashpal Bajwa (Canada) and Denmark’s Umair Butt deciding not to.

    The election launched the annual conference, with a number of big issues set to be debated in a new era for the governing body led by new chief executive Sanjog Gupta and his Indian counterpart Jay Shah.

    The CEC’s role is to promote and develop cricket worldwide, while governing and regulating the sport at the international level. It is highly coveted for Associate chiefs and seen as a stepping stone to get onto the ICC board – where the real power lies in global cricket.

    ForbesICC’s AGM: Test’s Future, Expanded T20 World Cup And USA Cricket Scrutiny

    Former Hong Kong chief Tim Cutler (Vanuatu), ex USA cricket governing body administrator Sankar Renganathan (Sierra Leone), Stella Siale (Samoa) and Sarah Gomersall (Jersey) also ran.

    Damodar had three terms on the CEC until 2023 before returning late last year after Mubashshir Usmani, a rising administrator at the helm of the Emirates Cricket Board, was elected to the ICC board.

    The outspoken Damodar has been behind ambitious proposals such as reviving the Afro-Asia Cup and pushing more marquee events for Associate nations.

    Renganathan loomed as a wildcard and he has been well know as an outspoken critic of embattled USA Cricket, which is facing suspension.

    Voters were made up from 40 Associate Members and five regional representatives (Americas, Asia, Europe, East Asia-Pacific and Africa). Under ICC rules, candidates had to be a representative of an Associate Member or a current/past ICC director.

    Newly elected members will have two-year terms and will also be part of the Associate Member Committee helping govern and regulate the Associate level.

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  • July 31 deadline set to wind up Utility Stores – Business

    July 31 deadline set to wind up Utility Stores – Business

    ISLAMABAD: A meeting of the committee formed by the prime minister to oversee the closure and privatisation of the Utility Stores Corporation (USC) was held at the Finance Division on Wednesday.

    Chaired by Finance Minister Muhammad Aurangzeb, the meeting was attended by Special Assistant to the Prime Minister on Industries and Production Haroon Akhtar Khan, secretaries of the Establishment, Finance, and Industries & Production divisions, the USC managing director, and senior officials of the Finance Division.

    The committee, mandated to ensure a smooth and transparent closure process, is tasked with devising a fair Voluntary Separation Scheme (VSS) for USC employees and recommending a structured timeline for privatisation.

    To facilitate a comprehensive review, Mr Aurangzeb constituted a sub-committee led by the Establishment Secretary, with representation from the Finance and Industries & Production divisions. The sub-committee will examine the legal and operational framework, scale, and structure of the proposed VSS, and submit its report by the end of the week.

    Sub-body formed to finalise VSS and assess privatisation options

    The findings will allow the main committee to consolidate its recommendations for submission to the prime minister in accordance with its terms of reference.

    The committee reviewed progress on its assigned tasks and held detailed discussions on the path forward. It reaffirmed the government’s decision to wind up all USC operations by July 31.

    Deliberations focused on formulating a financially viable and equitable VSS, with particular attention to the projected size, fiscal impact, and the legal and operational complexities involved.

    It was also recommended that the Privatisation Commission be consulted to assess the most effective model for divestment, including the feasibility of full privatisation or selective asset sales associated with USC operations.

    Established in 1971, USC is a state-owned enterprise tasked with supplying essential commodities at subsidised rates, primarily targeting low-income households. It currently operates over 4,000 retail outlets nationwide.

    According to the Finance Ministry’s Federal State-Owned Enterprises (SOE) Performance Overview for the first half of FY25, USC posted a loss of Rs4.1bn over six months, with cumulative losses rising to Rs15.5bn — highlighting persistent structural and operational challenges.

    Published in Dawn, July 17th, 2025

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  • Jenna Bush reveals what really makes her husband ‘grumpy’

    Jenna Bush reveals what really makes her husband ‘grumpy’

    Jenna Bush reveals what really makes her husband ‘grumpy’

    Jenna Bush Hager’s husband, Henry Hager, has some clear boundaries when it comes to publicizing his family.

    In a recent chat on her Today with Jenna & Friends show, the 43-year-old host talked about her husband’s reaction when some personal stories were shared on her platform.

    “I think it’s in the same vein as when you’re writing,” Bush Hager shared July 16 episode of her show. “You’re like, ‘Wait, whose story is this? Am I telling my story or is this posting because the kids are doing something really cute?”

    “And will it embarrass them someday? It might feel funny and cute now, but if it’s up forever, will you regret posting it?” guest co-host Willie Geist reflected.

    Jenna, who tied the knot with Henry in 2008 and shares three children, Mila, 12, and Poppy, 9, and son Hal, 5, admitted her husband knows how to protect the family’s privacy.

    “One of the great things about Henry is he always is thinking that way, he just believes we should have privacy as a family. So if I say something — maybe on this show — that gets pickup, he gets grumpy about it.”

    The TV personality weighed in on Henry’s approach, noting, “It helps me realize that I should be better for Mila, for Poppy and Hal.”


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  • Pakistani drama group stages Ramayana

    Pakistani drama group stages Ramayana





    Pakistani drama group stages Ramayana – Daily Times


































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  • Ahsan Khan gets flak over clip with Javed Akhtar and Shabana

    Ahsan Khan gets flak over clip with Javed Akhtar and Shabana





    Ahsan Khan gets flak over clip with Javed Akhtar and Shabana – Daily Times


































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  • US firms eye investment in Pakistan’s port sector – Business

    US firms eye investment in Pakistan’s port sector – Business

    A participant speaks at the webinar on investment opportunities at Pakistani ports on Wednesday.—Courtesy US consulate

    ISLAMABAD: Over 65 US companies joined a landmark webinar on Wednesday to explore commercial opportunities at Karachi Port and Port Qasim.

    The webinar hosted by the US Department of Commerce’s International Trade Administration and the US Department of State, in collaboration with the Ministry of Maritime Affairs, part of the ‘Gateways to Growth: South Asia Port Opportunities’ series, has opened new doors for American commercial services in the port sector of Pakistan.

    The webinar served as a strategic platform for American companies to engage directly with Pakistani port officials and private operators.

    “US investors have made substantial contributions to Pakistan’s development, and we are confident that the port sector will be another area where we can achieve great success together,” said US Consul General Scott Urbom in Karachi, emphasising the role of partnership in fostering long-term commercial ties.

    “We believe that by working together, we can unlock the full potential of Pakistan’s port sector, create new opportunities for American businesses, and contribute to Pakistan’s economic development,” he said.

    Senior representatives from the Ministry of Maritime Affairs, Port Qasim Authority, Abu Dhabi Ports, which operates Karachi Gateway Terminal Ltd, and Dubai Ports World, which operates Qasim International Container Terminal, outlined Pakistan’s infrastructure goals, regulatory landscape, and trade priorities, and participated in the webinar.

    The hybrid session highlighted how American firms can support Pakistan’s port development plans, helping expedite trade flows and build new supply chain linkages between our countries.

    Ean Hundley, Director of ICT and Infrastructure Policy at the US International Development Finance Corporation, noted, “This initiative equips US companies with market intelligence and direct access to local decision-makers, enabling them to capitalise on infrastructure opportunities across South Asia.”

    Published in Dawn, July 17th, 2025

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