Author: admin

  • Jude Law on being in the driver’s seat for Netflix’s ‘Black Rabbit’

    Jude Law on being in the driver’s seat for Netflix’s ‘Black Rabbit’

    Jude Law and his producing partner Ben Jackson have been on plenty of film sets, absorbing lessons from masters including Anthony Minghella (“Cold Mountain”) and Steven Soderbergh (“Side Effects”).

    But for Law, Jackson and their production company, Riff Raff Entertainment, their new Netflix limited series “Black Rabbit,” debuting Sept. 18, marks a big step: It’s their first episodic TV effort produced from inception.

    Created by Zach Baylin and Kate Susman, the eight-episode series stars Law as the ambitious owner of a New York hot spot whose life is thrown into turmoil when his drug- and gambling-addicted brother, played by Jason Bateman, comes back into the business. It’s a sort of grim and gritty Cain-and-Abel story for the restaurant scene, complete with debt-collecting goons, severed digits and armed robbery.

    “It was a slice of New York life that we felt we both knew,” Law said by video from London. “What I loved was the fraternal heartbeat in its center and the question it raised: How far does one go for someone you love?”

    Founded in 2017, Riff Raff locked in millions of dollars in financing from venture firm Calculus Capital about three years ago to expand its development slate and hire additional executives.

    Law isn’t going to lie. It can be easier for him to sell a movie or TV series he has in development when he’s planning to star in it.

    But simply making vehicles for the “Talented Mr. Ripley” actor isn’t all he and Jackson have in mind for Riff Raff. Of the dozens of projects the firm has in development, only a handful have the actor attached. Upcoming efforts include a Sharon Horgan-scripted romantic drama film, a historical drama from Justin Kuritzkes and a major TV drama by writer Jonathan Glatzer.

    The five-person Riff Raff is based primarily in London but has a growing presence in Los Angeles, where Jackson spends half his time. Previous credits include the 2024 thriller “The Order” and the 2021 drama “True Things.”

    This interview was edited for clarity and length.

    Why did you want to make this show, “Black Rabbit”?”

    Jude Law: “Black Rabbit” is a very good example of what we hoped to build and foster in the company. It came out of relationships that we had forged. So in this example, Zach Baylin, whom we’ve worked with on “The Order,” had mentioned this idea for a show he had with his partner, Kate Susman, and passed it on to Ben. It felt familiar, and yet it felt like there was fresh territory being covered.

    Ben Jackson: It also felt that there could be something incredibly cinematic about this piece as well, which is something that as a company we really want to bring to any TV we do.

    Law: We were very much along for the ride on “The Young Pope” and “The New Pope,” learning as young producers. But with this, being front and center and really being able to steer it and relish what episodic TV offers you. … If you trust the map you have, and you trust the team around you, that’s a very exciting creative situation to be in. And that was a really wonderful experience for Ben and me to flex a new muscle as producers in the driver’s seat.

    What learnings did you pick up from “The Young Pope” and “The New Pope?”

    Law: I mentioned those two because we were fortunate enough to have a producer credit. But I would honestly credit every set and every director that Ben and I have been on a set with for the last 20-odd years together. You learn pretty quickly what you think works and what you think doesn’t work. One of the reasons Ben and I ended up creating the company was the inspiration we drew from our experiences of being on a set with Anthony Minghella or Steven Soderbergh.

    Jackson: There’s no better way of learning anything than doing it. It’s osmosis. Everybody makes mistakes, but you see how things work. The late, great Anthony Minghella — whose set I first worked on with “Cold Mountain” — had this overriding sense of family. Everybody was included. Everybody had a role to play.

    Having Troy Kotsur as a menacing bad guy in the show was pretty interesting, given that I think a lot of people know him as the dad from “CODA.”

    Law: I wish one of us could take responsibility for that brilliant choice. It actually came while Zach was on the Academy campaign trail for “King Richard.” His path crossed with Troy, who was similarly attending those events for “CODA.” I think Troy suggested it. They talked about potential roles and Troy said, “I would love to play a really bad guy.” And that germinated in Zach’s imagination, and he wrote a wonderful role for Troy. But Troy turned up and absolutely delivered. There’s an incredible intensity and stillness, and I think we all learned a huge amount from working with him.

    What’s different about Riff Raff and what you guys are trying to do here with this company?

    Law: Like most other companies, we’re trying to make great work. We’re trying to empower people we believe in and are inspired by to make great work. This has always been, for me personally, an opportunity to stretch my input into filmmaking beyond what I do in front of the camera. At the same time, I really appreciate and love the potential of having a company where it’s allowed me as an actor to hold the reins a little firmer and introduce roles that I think the marketplace might not associate me with. But so many of these projects have their own legs, and our aim is to build a brand that people go to because they enjoy our output, not because it’s attached to me.

    Jackson: I think there’s a danger when you have a talent-led company, where people say, oh, well, if it’s his company, we know what we’re going to get. And I think our goal is to make sure that it’s eclectic.

    With “Black Rabbit,” were you always attached to play Jake, the brother who owns the restaurant?

    Law: I was absolutely attached, but …my focus was in the belief of the whole piece. And you know what it was, even when we went to Jason and we were interested in asking him to come on board and for him to direct, I think I had the idea: “Well, shouldn’t Jason be the brother?” But I wasn’t sure at the time whether I was Vince or Jake. And so, yeah, that conversation was had quite late in the day. You know, there was plenty of time for us to learn our lines and swap costumes.

    Jason’s a good choice because he’s done the dirtbag kind of guy before. Even in “Arrested Development,” he’s got a bit of a mean streak.

    Law: But he does it with an incredible — uh, wink, yeah — humor and humanity, which is a very hard nuance to pull off.

    How much has the company grown over the years?

    Law: Ben really changed it all in that it was sort of being financed by myself. We were doing it over my kitchen table on the hoof. And I think he realized we had to make the leap and really decide whether we were going to make a go of it or not. And it was a vital decision to make, and we were fortunate enough to find funding, and fortunate enough, therefore, to be able to broaden the team. And then obviously, first-look deals give us some firepower to develop and produce, and the team has just empowered us to embark on sourcing the slate.

    Jackson: We’re also very aware of what our limits are. We don’t want to be a company that’s going around going, “Oh, that’s an issue, but we’ll option that,” and then it sits there, going nowhere. It’s a lot of work put into developing anything, and so you’ve all got to be on board. Otherwise, things drift. Momentum is key in this industry. You need to keep things moving.

    What’s the market like right now from your perspective in terms of getting things greenlit?

    Law: I think the problem is nobody knows. You have to have conviction in what you’re trying to say. If you have a writer with a great track record, or a director with a great track record, there’s a certain amount of, “Look, I’ve done it before, I can do it again.” But even then everyone is second-guessing right up to the end. It’s just a case of nudging it forward without losing sight of the reason you all got on board in the first place and not budgeting yourself into a position where you’re putting too much pressure on yourselves.

    I go back to relationships, building relationships with the people you can trust, as distributors, who you know will have your back, or a company like Netflix, which has had our back on this from day one.

    Jackson: You have to be adaptable. I think there’s no finite formula for making a successful film or show. Does it fit the world we live in right now? No one knows. I think what you have to be is you have to be committed to what you’re doing.

    What’s the right level of activity for the company?

    Law: Well, that’s hard to say. But we have a slate of 30-plus projects.

    Having now really got a good foothold with the team that we’ve been allowed to assemble in the U.K., we’re very keen to purchase a more significant foothold in the U.S. Ben spends half his time there, and we’re hoping to just build. I think recognizing the bridge between the U.K. and the U.S. markets is very important.

    Well, studios are making so many of their productions in the U.K. these days.

    Law: So much so that it’s almost impossible to get crew and studio space, so it’s possible that we may end up in Budapest, Prague or Berlin.

    What other projects are you excited about?

    Law: Something that we’ve been developing with Justin Kuritzkes (“Challengers”), based loosely on the documentary “Best of Enemies,” is a very exciting script that we’re putting together. It was interesting, the new book on William F. Buckley Jr. just came out, and all the reviews are talking about his influence on the current Republican Party, which is something we spotted a while back.

    Is there any sort of through line for what you find yourselves drawn to?

    Law: It’s a really good question. I hope that I have demonstrated through the choices I’ve made as an actor that I find most genres and most forms of storytelling interesting. I’ve really relished being in big-budget, heavy IP [intellectual property] pieces and working on tiny independents. I hope the company will reflect that. I hope our signature is quality.

    Stuff we wrote

    Number of the week

    $3.67 billion

    The summer box office totaled an unimpressive $3.67 billion in ticket sales from May through Labor Day, down slightly from last year’s similarly soft tally and way below prepandemic levels, when grosses typically exceeded $4 billion.

    That’s bad. Blame a lack of true blockbusters, streaming, shortened theatrical windows and an over-reliance on aging franchises. Read Samantha Masunaga’s story for more on the winners and losers.

    Finally …

    Listen: Cass McCombs, “Interior Live Oak”; The Beths, “Straight Line Was a Lie.”

    Continue Reading

  • Cannabis May Help You Sleep Better, Researchers Say

    Cannabis May Help You Sleep Better, Researchers Say

    Share on Pinterest
    A new study found that daily cannabis use improved sleep in people with insomnia. Getty Images
    • Cannabis products consumed on a daily basis resulted in better sleep for people with insomnia in a new study.
    • Participants also reported improvements in anxiety and depression as well as pain levels.
    • Cannabis continued to reduce insomnia throughout the 18-month trial, although the effects waned over time.
    • Experts caution that tolerance for cannabis may reduce its value as a long-term sleep aid, and note other health risks associated with chronic cannabis use.

    People with insomnia experienced improved sleep with regular cannabis use in a new study.

    The authors report that participants experienced less insomnia using cannabis products daily throughout the 18-month study period. The findings were published on August 27 in PLOS Mental Health.

    Estimates of the number of people who have difficulty sleeping range from 10%, as cited by the study authors, to as high as 30%.

    Effective medical treatments for insomnia are available, but they often come with side effects and a risk of developing a dependence.

    In the new study, researchers recruited people who had been diagnosed with primary insomnia and who were registered with the UK Medical Cannabis Registry. The final study cohort was 124 participants, 18 years old or older.

    Individuals were each prescribed the same controlled daily dosage of cannabis supplied by the authors of the study.

    Cannabis was consumed in oil or dried flower form, or a combination of both. No external cannabis was allowed during the trial period.

    A total of 11 participants experienced 112 adverse events, including fatigue, dry mouth, and insomnia, though none of these were considered disabling or life threatening.

    At the end of the 18-month trial, participants said that cannabis was still helping them sleep. However, the strongest benefit was observed during the first month of the trial and slowly decreased through the study period.

    In addition to reporting insomnia relief, individuals said they also experienced less pain and that their levels of anxiety and depression improved throughout the trial.

    “Many people with anxiety and depression have trouble falling asleep because of racing thoughts, so that’s where cannabis helps in the short term.”

    Previous research studying the effects of cannabis on sleep quality has not consistently confirmed its value.

    The study followed participants for a year and a half, however, it’s unclear whether cannabis is a viable long-term sleep aid.

    The authors note that one potential issue is how the body develops a tolerance for cannabis, meaning that consuming more and more of it may be necessary to achieve the same result.

    They suggest that the decrease in the effectiveness of cannabis over time is likely related to participants’ growing tolerance.

    “There is evidence indicating the consistent medical use of cannabis is associated with higher usage over time, resulting in increased risk of tolerance and dependence,” Patel said.

    Bonaguro noted that cannabis use often becomes a cycle. “It gives short-term relief of anxiety or depression, but with prolonged use, tolerance builds, dependency develops, and both mood and sleep get worse,” she said.

    The study investigated daily consumption of cannabis products for insomnia, and Patel noted there are side effects associated with frequent use.

    However, as a 2021 review notes, cannabis may compare favorably “in regards to safety and tolerability with other drugs, such as opioids, and it is important to weigh up the benefits of use vs the risk of dependence.”

    The review further notes that the risk of adverse side effects, such as tolerance or dependence, may not outweigh the medicinal benefits of using cannabis for the management of chronic health conditions, “highlighting the need for a medicine with a good safety profile.”

    As for sleep, however, cannabis use may be disruptive for some. Some research suggests that cannabis may affect slow-wave (N3) sleep. There is also suspicion that it fractures REM and deep sleep.

    “One more thing I frequently heard from clients who use it regularly or sporadically is that they can’t remember their dreams,” said Bonaguro. “This makes sense since THC is well-documented to suppress REM sleep, which is when most dreaming occurs.”

    Patel added that chronic cannabis use has also been linked to psychiatric problems in susceptible individuals.

    The authors of the study conclude their report with an expression of their own concern.

    They note the likelihood that insomnia patients will develop a tolerance for cannabis may ultimately limit the substance’s usefulness as a long-term therapy, however successful it proved throughout the relatively short-term of the study period.

    Those successes alone, they argue, merit further randomized controlled trials of cannabis use in treating insomnia.

    Continue Reading

  • Clinical Audit of Acute Oxygen Therapy: Enhancing Patient Care at Atbara Teaching Hospital

    Clinical Audit of Acute Oxygen Therapy: Enhancing Patient Care at Atbara Teaching Hospital


    Continue Reading

  • Beta Blockers After Milder Heart Attacks Unhelpful, Possibly Harmful – Inside Precision Medicine

    1. Beta Blockers After Milder Heart Attacks Unhelpful, Possibly Harmful  Inside Precision Medicine
    2. Common heart attack drug doesn’t work and may raise risk of death for some women, new studies say  CNN
    3. Study finds beta blockers may raise risk of death in women | Tap to know more | Inshorts  Inshorts
    4. Effectiveness of Beta-Blockers in Reducing Mortality and Recurrence After Myocardial Infarction: A Systematic Review of Contemporary and Foundational Evidence  The Cureus Journal of Medical Science
    5. Research on beta blockers shows conflicting results  Semafor

    Continue Reading

  • ‘It’s a big result’ – Esteban Ocon and Ollie Bearman “very satisfied” with double-points finish for Haas at Zandvoort

    ‘It’s a big result’ – Esteban Ocon and Ollie Bearman “very satisfied” with double-points finish for Haas at Zandvoort

    Ollie Bearman managed to recover from a pit lane start to finish an incredible sixth in the Dutch Grand Prix, giving Haas much to celebrate as they brought home a double-points finish, with Esteban Ocon crossing the line in 10th.

    The result was extra impressive when considering their starting positions, but the drivers were keen to stress it was one born out of hard work, with excellent strategy calls contributing to their haul of points in Zandvoort.

    Bearman’s drive was arguably the more surprising, given the youngster opted for a pit lane start to change some power unit components after qualifying just 19th on Saturday. He started on the hard tyre and ran a very long first stint, Haas opting not to pit under the first Safety Car unlike the majority of the field.

    The team needed another Safety Car to make their strategy work, and they got just that when Charles Leclerc and Kimi Antonelli crashed, Bearman diving into the pits for his one and only stop. That left him solidly in the top 10, and not only did he hold station, but the rookie kept close enough to Antonelli to profit when the latter’s time penalties were applied.

    “We got lucky today for sure, but sometimes you need to be in the right place at the right time,” Bearman explained after the race.

    “Good calls on strategy, the car was quick as well which always has to be the case as well. The guys did a good job, gave me a great car. We were a bit unlucky I would say after Qualifying, we had a few misfortunes which meant that we started from last, but to score points today is a very good feeling.”

    Bearman had to work hard for his score, sticking close to his team mate in the first stint as both started to struggle on aging tyres, and then keeping some faster, fresher shod cars at bay. It was his first points score since Bahrain, and his best finish of the season so far.

    “Nice to get back in the points. It has been a long time coming for sure, the team have been working incredibly hard, and I think we are getting there step by step.

    “We’ve got some things to work on and also myself, I’m far from perfect, still making too many mistakes. But we are on the right path and I really have high hopes,” he concluded.

    Team work was key in Zandvoort, with Ocon – who started 18th and was the first Haas driver to breach the top 10 – helping Bearman at points in the race. The Frenchman could have felt aggrieved that his team mate finished ahead, given Ocon was running in front for much of the race – but he stopped one lap earlier than Bearman, and that cost him a handful of places.

    “It’s very positive as a team to have a double-points finish for both of us,” Ocon said. “Got a little bit unlucky with the Safety Car, I think I lost maybe three positions or four. But overall, very satisfied with that. Well done to Ollie, he has done a fantastic race also and that’s big for us, it is a big result.

    “We helped ourselves during the race. We were 10th and 11th during the time and Ollie dropped back from DRS and the team asked me to give him DRS [drag reduction system] and we just kept pushing forward, both of us together.

    “And then I boxed and the Safety Car came at the wrong time so I fell backwards, but Ollie benefited from that. So as a team it was good, definitely strong points. I knew there was something we could play here, even starting from the back, it makes crazy races for sure. But happy with the outcome for the team and hopefully we can do more of that at the next one.”

    Haas remain ninth in the Teams’ Championship, but at least have kept in touch with Kick Sauber ahead, and only need another strong weekend to close the gap in what is increasingly turning into an incredibly tight midfield fight.

    Continue Reading

  • Tech From NASA’s Hurricane-hunting TROPICS Flies on Commercial Satellites

    Tech From NASA’s Hurricane-hunting TROPICS Flies on Commercial Satellites

    NASA science and American industry have worked hand-in-hand for more than 60 years, transforming novel technologies created with NASA research into commercial products like cochlear implants, memory-foam mattresses, and more. Now, a NASA-funded device for probing the interior of storm systems has been made a key component of commercial weather satellites.

    The novel atmospheric sounder was originally developed for NASA’s TROPICS (short for Time-Resolved Observations of Precipitation structure and storm Intensity with a Constellation of SmallSats), which launched in 2023. Boston-based weather technology company Tomorrow.io integrated the same instrument design into some of its satellites.

    Atmospheric sounders allow researchers to gather data describing humidity, temperature, and wind speed — important factors for weather forecasting and atmospheric analysis. From low-Earth orbit, these devices help make air travel safer, shipping more efficient, and severe weather warnings more reliable.

    In the early 2000s, meteorologists and atmospheric chemists were eager to find a new science tool that could peer deep inside storm systems and do so multiple times a day. At the same time, CubeSat constellations (groupings of satellites each no larger than a shoebox) were emerging as promising, low-cost platforms for increasing the frequency with which individual sensors could pass over fast-changing storms, which improves the accuracy of weather models.

    The challenge was to create an instrument small enough to fit aboard a satellite the size of a toaster, yet powerful enough to observe the innermost mechanisms of storm development. Preparing these technologies required years of careful development that was primarily supported by NASA’s Earth Science Division.

    William Blackwell and his team at MIT Lincoln Laboratory in Cambridge, Massachusetts, accepted this challenge and set out to miniaturize vital components of atmospheric sounders. “These were instruments the size of a washing machine, flying on platforms the size of a school bus,” said Blackwell, the principal investigator for TROPICS. “How in the world could we shrink them down to the size of a coffee mug?”

    With a 2010 award from NASA’s Earth Science Technology Office (ESTO), Blackwell’s team created an ultra-compact microwave receiver, a component that can sense the microwave radiation within the interior of storms.

    The Lincoln Lab receiver weighed about a pound and took up less space than a hockey puck. This innovation paved the way for a complete atmospheric sounder instrument small enough to fly aboard a CubeSat. “The hardest part was figuring out how to make a compact back-end to this radiometer,” Blackwell said. “So without ESTO, this would not have happened. That initial grant was critical.”

    In 2023, that atmospheric sounder was sent into space aboard four TROPICS CubeSats, which have been collecting torrents of data on the interior of severe storms around the world.

    By the time TROPICS launched, Tomorrow.io developers knew they wanted Blackwell’s microwave receiver technology aboard their own fleet of commercial weather satellites. “We looked at two or three different options, and TROPICS was the most capable instrument of those we looked at,” said Joe Munchak, a senior atmospheric data scientist at Tomorrow.io.

    In 2022, the company worked with Blackwell to adapt his team’s design into a CubeSat platform about twice the size of the one used for TROPICS. A bigger platform, Blackwell explained, meant they could bolster the sensor’s capabilities.

    “When we first started conceptualizing this, the 3-unit CubeSat was the only game in town. Now we’re using a 6-unit CubeSat, so we have room for onboard calibration,” which improves the accuracy and reliability of gathered data, Blackwell said.

    Tomorrow.io’s first atmospheric sounders, Tomorrow-S1 and Tomorrow-S2, launched in 2024. By the end of 2025, the company plans to have a full constellation of atmospheric sounders in orbit. The company also has two radar instruments that were launched in 2023 and were influenced by NASA’s RainCube instrument — the first CubeSat equipped with an active precipitation radar.

    More CubeSats leads to more accurate weather data because there are more opportunities each day — revisits — to collect data. “With a fleet size of 18, we can easily get our revisit rate down to under an hour, maybe even 40 to 45 minutes in most places. It has a huge impact on short-term forecasts,” Munchak said.

    Having access to an atmospheric sounder that had already flown in space and had more than 10 years of testing was extremely useful as Tomorrow.io planned its fleet. “It would not have been possible to do this nearly as quickly or nearly as affordably had NASA not paved the way,” said Jennifer Splaingard, Tomorrow.io’s senior vice president for space and sensors.

    The relationship between NASA and industry is symbiotic. NASA and its grantees can drive innovation and test new tools, equipping American businesses with novel technologies they may otherwise be unable to develop on their own. In exchange, NASA gains access to low-cost data sets that can supplement information gathered through its larger science missions.

    Tomorrow.io was among eight companies selected by NASA’s Commercial SmallSat Data Acquisition (CSDA) program in September 2024 to equip NASA with data that will help improve weather forecasting models. “It really is a success story of technology transfer. It’s that sweet spot, where the government partners with tech companies to really take an idea, a proven concept, and run with it,” Splaingard said.

    By Gage Taylor

    NASA’s Goddard Space Flight Center, Greenbelt, Md.

    Continue Reading

  • Timing perfect again for Dwight Howard as he soars into Hall of Fame

    Timing perfect again for Dwight Howard as he soars into Hall of Fame

    Check out the top plays that made Dwight Howard a perennial All-Star throughout his career.

    When change came upon the NBA without warning or apology, when philosophical shifts meant the game would never be the same again, no one had a better sense of timing than Dwight Howard.

    He went straight from high school to the NBA in 2004, just before the league abolished that loophole leap.

    He arrived as a low-post big man and focal point of the offense, just before that species was diminished and all but declared extinct when the floor was spread and enhanced by the 3-point shot.

    Yes, all true.

    But most of all, and the reason he’ll be inducted Saturday into the Naismith Memorial Basketball Hall of Fame, Howard took advantage of the situation before the door slammed shut. He wasn’t a farce, unlike some highly touted talents. Instead, he was a force, especially on defense, where he distanced himself from the peers of his generation.

    Eight-time All-NBA, three-time Kia Defensive Player of the Year, a five-time rebounding champion, a two-time blocked shot leader — all accomplished by the time he turned 28.

    He was both self-appointed and, during the first several seasons of his career, Superman.

    A few words about that caped crusader: Howard famously wore the garb and the “S” on his chest during the 2008 dunk contest (which he won, the rare center to do so), and it captured, for both better and worse, the personality of the player.

    Howard was hopelessly happy-go-lucky, charmingly goofy at times, and forever searching for a good time no matter the situation. His critics, of which there were a few both inside and outside the league, thought he didn’t take the game seriously enough.

    Perhaps more accurately, Howard didn’t take himself so seriously. He knew he was living a dream and refused to be swallowed up by the fantasy world in which he and other millionaire athletes lived.

    And most of that time was spent, coincidentally, in the home of make-believe and cartoon characters. Disney World may have had bigger attractions, but none involving basketball, where Howard repositioned Orlando and the Magic not long after the defection of Shaquille O’Neal.

    He took the Magic to the NBA Finals in 2009, and in the seasons both before and after that, Howard was arguably the most dominant big man in basketball, especially with O’Neal long past his prime by then. From 2007-10, he averaged 19.8 ppg, 13.7 rpg and 2.6 bpg, and in his first six seasons, he missed just four games.

    His career soon took him on a multi-team journey punctuated by false starts, dead ends, injuries, a brief resurgence and finally, a championship with the Lakers in 2020. So this is really about two Dwight Howards stretched over 18 years: one who dominated during the decline of the low-post big man, the other who managed to carve out productivity and longevity during a changing game.

    He came into the league as a savior, an 18-year-old who stood 6-foot-10 with shoulders already broad enough to shed defenders and carry a team — in this case, the desperate Magic. Orlando was fresh off a 21-win season and seemingly far removed from the Shaq-Penny Hardaway rambunctious seasons.

    Initially, Howard was raw, especially offensively, but steady. In his rookie season, he set records as the youngest to average 10 rebounds in a season, the youngest to average a double-double and the only player ever to start all 82 games directly out of high school.

    He actually was a power forward then, but after adding weight, Howard shifted permanently to center in his second season. He was undersized in center matchups, yet had the strength to hold his own against heavier players. And the big difference — Howard was far quicker than the competition.

    That’s why Howard was at times unstoppable. He was quicker to rebounds, could beat his man down the floor for dunks and layups, was able to spin free for lob passes and more easy buckets, and reacted swiftly on defense for blocked shots.

    His offense was slower to adjust, and Howard’s inability to expand his shooting range would eventually cost him in his career. Still, Howard could dominate in the playoffs, and his 40-point, 14-rebound showing in Game 6 of the 2009 Eastern Conference Finals vs. Cleveland was his defining moment. He was beastly in that game to clinch Orlando’s berth in the Finals.

    The Magic lost to Kobe Bryant and the Lakers in that series, and never returned with Howard. By 2012, turbulence between the franchise and Howard emerged, and the two sides drifted apart in multiple ways.

    As if that wasn’t enough, Howard suffered a back injury, which required surgery that summer. The injury haunted Howard for another season, which was spent in L.A. with the Lakers. That and frequent clashes with Bryant contributed to a disappointing season. The Lakers went from championship favorites to being swept in the first round by the Spurs, with Howard ejected early in the third quarter of Game 4.

    The search for happiness and the right fit was about to begin for Howard. His Lakers experience lasted just one season. He signed with the Houston Rockets to pair up with James Harden, but a knee injury sapped Howard’s production and he never jelled with Harden.

    Next stop, Atlanta, his hometown. Again, what began with high expectations soon soured as Howard lasted one season before the Hawks shipped him to the Charlotte Hornets in what was essentially a giveaway.

    The next two years were odd. Howard technically spent it with four teams, but he was cut by the Nets and Grizzlies before playing a game. He played just nine games with the Wizards because of back issues. The league by then favored big men who could shoot. Howard was inching closer to being obsolete — along with being old and injury-prone.

    This is where he found a measure of satisfaction, in an unlikely place. The Lakers, thin in the middle beyond Anthony Davis, needed big man insurance and took out a policy on Howard, giving him another chance in LA. Although his role would change drastically along with diminished minutes and touches, Howard seized the chance to go out in style.

    Which he did. He came off the bench in 2019-20, playing 69 games while averaging a very respectable 7.3 rpg in just 19 minutes per game. Even better, Howard meshed with Davis and LeBron James for that one friction-free season.

    To summarize, this was a Hall of Fame career, and actually, Howard had a strong case just on his eight seasons in Orlando alone.

    Dwight Howard delivers an unbelievably accurate impersonation of Charles Barkley.

    What’s intriguing is how Howard was left off the NBA’s 75th Anniversary team. That remains a sore subject with him, as it should. Howard’s three Kia Defensive Player of the Year trophies and two trips to the Finals should’ve almost automatically qualified him.

    Unquestionably, he was among the best at his position and in his role during his generation. The double-doubles, rebounding titles, impact in the paint and his game-changing defensive play placed him in very select company.

    In retrospect, Howard was perhaps better off staying in Orlando than his ill-fated season with the Lakers and Bryant, at least from a perception standpoint. But he wanted a championship badly and thought his chances were better in L.A. than Orlando.

    Turns out that hunch was true — just several years later, when, by then, he was a supporting player during his second Lakers stint.

    Here’s what they said about Howard:

    • LeBron James: “While everyone else was writing him off, we felt like we could give him a great opportunity (with the Lakers), and we believed in him. We believed his word, and he’s making the most of it, and we’re truly excited to have him here right now.”
    • Jameer Nelson, Magic point guard from 2004-14: “Dude could run and he could catch. You could throw bounce passes, chest passes, over the top, whatever. His hands were crazy .. and defensively, you know people, they see Dwight as silly and playful, but dude was the smartest defender I’ve ever been on a team with.”
    • Alex Martins, Orlando Magic CEO: “Players are young when they are playing in the NBA. They don’t recognize at the time the impact that a coach has on them. Or the impact that the franchise has on them. But then they look back on their career and see the many places they have been and the experiences that they had, they know the places that meant the most to them. Clearly, of all the places Dwight has played, this organization, this city meant more to him than any place in his career. We look fondly on his time as well.”

    * * *

    Shaun Powell has covered the NBA for more than 25 years. You can e-mail him here, find his archive here and follow him on Twitter.

    The views on this page do not necessarily reflect the views of the NBA, its clubs or Warner Bros. Discovery.


    Continue Reading

  • Reed to defend at Link Hong Kong Open, Watson enters field

    Reed to defend at Link Hong Kong Open, Watson enters field

    Kho, a Hong Kong Golf Club ambassador, Asian Games gold medalist and the first Hongkonger to win on the Asian Tour, is thrilled to return to his home Open.

    He said: “It is always a special occasion to play at Hong Kong Golf Club in front of family, friends and golf fans. This is a historic tournament I grew up watching as a youngster and now to compete in it as a professional, on my home course against some of the biggest names in world golf, is a real privilege.”

    First played in 1959, the tournament is the longest-running international sporting event in Hong Kong and one of Asia’s most prestigious golf championships, a tradition spanning more than 65 years.

    Hong Kong Golf Club captain Andy Kwok said: “We are all set for four magnificent days of action, as the historic Link Hong Kong Open continues to grow in prestige on the international stage.

    “To be selected as one of only a handful of pathway events reflects the rich heritage of our Club and the 65-year-old championship, but also Fanling’s global reputation as one of golf’s foremost tournament venues. We very much look forward to seeing the fans come out in force to support our Hong Kong players and watch some of the most exciting players in the game.”

    It is not just the Link Hong Kong Open title at stake – important Rankings points are also up for grabs.

    The tournament is the eighth stop on The International Series, the set of 10 elevated events on the Asian Tour calendar that provides a pathway onto the LIV Golf League for the end-of-season Rankings champion.

    “The International Series is all about providing players with opportunity, and a pathway to elite-level golf,” said Rahul Singh, Head of The International Series. “This year’s edition of the Link Hong Kong Open is the perfect example of our ethos. With the promise of vital rankings points in the race for a LIV Golf spot as well as a pathway to two majors for the champion, we look forward to another thrilling edition.”

    Held throughout the year across Asia, Europe and the Middle East, The International Series contributes $23 million (U.S.) to the Asian Tour’s 2025 total prize fund.

    “The Asian Tour is braced for a thrilling second half of the season, with the Link Hong Kong Open once again set to play a pivotal role. This year’s event will reach a new level of recognition as the winner will receive an invite to the Masters Tournament and The Open – an incredible endorsement for one of Asia’s most illustrious national opens.” said David Rollo, Chief Operating Officer for the Asian Tour.

    Starting in 2024, Link Asset Management Limited (Link) became title sponsor of the Hong Kong Open golf championship for three years. Through this iconic partnership, the Hong Kong Golf Club and Link aim to promote the game of golf within the wider local community across the city and make it more accessible to the public.

    Link Group CEO George Hongchoy said: “As Link celebrates its 20th anniversary in 2025, we are proud to mark our second year of partnership with the prestigious Link Hong Kong Open. This collaboration exemplifies our role as a Hong Kong-headquartered real estate investment manager embracing international opportunity, while reflecting our belief in sport’s power to inspire communities and bring people together. With Hong Kong also hosting the golf competition of the 15th National Games this November, we are excited to celebrate the vibrancy and shared joy of golf across the city.”

    In keeping with the event theme of the Link Hong Kong Open – Open For All – admission is free for the first two rounds on Thursday and Friday. Season passes, including the final two days on Saturday and Sunday, cost HK$300 for a weekend pass or HK$200 per day. Fans 18 and under will enjoy free entry across all four days when accompanied by a ticketed adult or with a photo ID containing date of birth.

    With off-course entertainment to complement the world-class action, the Link Hong Kong Open 2025 is a great day out for the entire family, featuring an array of activities in the tournament fan village.

    More big names will be announced soon. For more information, please visit www.thehongkongopen.com. Purchase tickets by clicking here.

    Continue Reading

  • Miranda JJ, Barrientos-Gutiérrez T, Corvalan C, Hyder AA, Lazo-Porras M, Oni T, et al. Understanding the rise of cardiometabolic diseases in low- and middle-income countries. Nat Med. 2019;25:1667–79. https://doi.org/10.1038/s41591-019-0644-7.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Han Y, Hu Y, Yu C, Sun D, Pang Y, Pei P, et al. Duration-dependent impact of cardiometabolic diseases and Multimorbidity on all-cause and cause-specific mortality: a prospective cohort study of 0.5 million participants. Cardiovasc Diabetol. 2023;22:135. https://doi.org/10.1186/s12933-023-01858-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kivimäki M, Kuosma E, Ferrie JE, Luukkonen R, Nyberg ST, Alfredsson L, et al. Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe. Lancet Public Health. 2017;2:e277–85. https://doi.org/10.1016/s2468-2667(17)30074-9.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen W, Wang X, Chen J, You C, Ma L, Zhang W, et al. Household air pollution, adherence to a healthy lifestyle, and risk of cardiometabolic multimorbidity: results from the China health and retirement longitudinal study. Sci Total Environ. 2023;855:158896. https://doi.org/10.1016/j.scitotenv.2022.158896.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Su B, Liu C, Chen L, Wu Y, Li J, Zheng X. Long-term exposure to PM2.5 and O3 with cardiometabolic multimorbidity: evidence among Chinese elderly population from 462 cities. Ecotoxicol Environ Saf. 2023;255:114790. https://doi.org/10.1016/j.ecoenv.2023.114790.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zhang D, Tang X, Shen P, Si Y, Liu X, Xu Z, et al. Multimorbidity of cardiometabolic diseases: prevalence and risk for mortality from one million Chinese adults in a longitudinal cohort study. BMJ Open. 2019;9:e024476. https://doi.org/10.1136/bmjopen-2018-024476.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yu B, Jia S, Sun T, Liu J, Jin J, Zhang S, et al. Sarcopenic obesity is associated with cardiometabolic Multimorbidity in Chinese middle-aged and older adults: a cross-sectional and longitudinal study. J Nutr Health Aging. 2024;28:100353. https://doi.org/10.1016/j.jnha.2024.100353.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Collaboration TERF. Association of cardiometabolic Multimorbidity with mortality. JAMA. 2015;314:52. https://doi.org/10.1001/jama.2015.7008.

    Article 
    CAS 

    Google Scholar 

  • Dove A, Xu W. Cardiometabolic Multimorbidity and cognitive decline. Lancet Healthy Longev. 2023;4:e241–2. https://doi.org/10.1016/s2666-7568(23)00053-3.

    Article 
    PubMed 

    Google Scholar 

  • Zhang H, Jiang S, Hao M, Li Y, Hu Z, Jiang X, et al. Association of cardiometabolic Multimorbidity with motoric cognitive risk syndrome in older adults. Alzheimers Dement (Amst). 2023;15:e12491. https://doi.org/10.1002/dad2.12491.

    Article 
    PubMed 

    Google Scholar 

  • Fortin M, Dubois M-F, Hudon C, Soubhi H, Almirall J. Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes. 2007;5:52. https://doi.org/10.1186/1477-7525-5-52.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu X, Zhang Y, Luo D, Chen B, Lai C, He C, et al. Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cardiometabolic Multimorbidity among middle-aged and older adults in China. BMC Public Health. 2025;25:570. https://doi.org/10.1186/s12889-025-21757-w.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ascaso JF, Pardo S, Real JT, Lorente RI, Priego A, Carmena R. Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism. Diabetes Care. 2003;26:3320–5. https://doi.org/10.2337/diacare.26.12.3320.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Adeva-Andany MM, Martínez-Rodríguez J, González-Lucán M, Fernández-Fernández C, Castro-Quintela E. Insulin resistance is a cardiovascular risk factor in humans. Diabetes Metab Syndr. 2019;13:1449–55. https://doi.org/10.1016/j.dsx.2019.02.023.

    Article 
    PubMed 

    Google Scholar 

  • Tahapary DL, Pratisthita LB, Fitri NA, Marcella C, Wafa S, Kurniawan F, et al. Challenges in the diagnosis of insulin resistance: focusing on the role of HOMA-IR and tryglyceride/glucose index. Diabetes Metab Syndr. 2022;16:102581. https://doi.org/10.1016/j.dsx.2022.102581.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6:299–304. https://doi.org/10.1089/met.2008.0034.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wu Z, Liu L, Wang W, Cui H, Zhang Y, Xu J, et al. Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients with premature coronary artery disease: a retrospective cohort study. Cardiovasc Diabetol. 2022;21:142. https://doi.org/10.1186/s12933-022-01576-8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jiang Y, Shen J, Chen P, Cai J, Zhao Y, Liang J, et al. Association of triglyceride glucose index with stroke: from two large cohort studies and Mendelian randomization analysis. Int J Surg. 2024;110:5409–16. https://doi.org/10.1097/js9.0000000000001795.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wen J, Wang A, Liu G, Wang M, Zuo Y, Li W, et al. Elevated triglyceride-glucose (TyG) index predicts incidence of prediabetes: a prospective cohort study in China. Lipids Health Dis. 2020;19:226. https://doi.org/10.1186/s12944-020-01401-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • The Emerging Risk Factors Collaboration. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011;377:1085–95. https://doi.org/10.1016/s0140-6736(11)60105-0.

    Article 
    PubMed Central 

    Google Scholar 

  • Jabłonowska-Lietz B, Wrzosek M, Włodarczyk M, Nowicka G. New indexes of body fat distribution, visceral adiposity index, body adiposity index, waist-to-height ratio, and metabolic disturbances in the obese. Kardiol Pol. 2017;75:1185–91. https://doi.org/10.5603/kp.a2017.0149.

    Article 
    PubMed 

    Google Scholar 

  • Pasdar Y, Moradi S, Moludi J, Saiedi S, Moradinazar M, Hamzeh B, et al. Waist-to-height ratio is a better discriminator of cardiovascular disease than other anthropometric indicators in Kurdish adults. Sci Rep. 2020;10:16228. https://doi.org/10.5603/kp.a2017.0149.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Moltrer M, Pala L, Cosentino C, Mannucci E, Rotella CM, Cresci B. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) e waist body mass index (wBMI): which is better? Endocrine. 2022;76:578–83. https://doi.org/10.1007/s12020-022-03030-x.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Dang K, Wang X, Hu J, Zhang Y, Cheng L, Qi X, et al. The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018. Cardiovasc Diabetol. 2024;23:8. https://doi.org/10.1186/s12933-023-02115-9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ren Q, Huang Y, Liu Q, Chu T, Li G, Wu Z. Association between triglyceride glucose-waist height ratio index and cardiovascular disease in middle-aged and older Chinese individuals: a nationwide cohort study. Cardiovasc Diabetol. 2024;23:247. https://doi.org/10.1186/s12933-024-02336-6.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xu F, Su X, Dai F, Ye Y, Hu P, Cheng H. Association between triglyceride glucose-waist height ratio and stroke: a population-based study. Front Endocrinol (Lausanne). 2025;16:1510493. https://doi.org/10.3389/fendo.2025.1510493.

    Article 
    PubMed 

    Google Scholar 

  • Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China health and retirement longitudinal study (CHARLS). Int J Epidemiol. 2014;43:61–8. https://doi.org/10.1093/ije/dys203.

    Article 
    PubMed 

    Google Scholar 

  • Xu J, Cai D, Jiao Y, Liao Y, Shen Y, Shen Y, et al. Insights into the complex relationship between triglyceride glucose-waist height ratio index, mean arterial pressure, and cardiovascular disease: a nationwide prospective cohort study. Cardiovasc Diabetol. 2025;24:93. https://doi.org/10.1186/s12933-025-02657-0.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Han Y, Hu Y, Yu C, Guo Y, Pei P, Yang L, et al. Lifestyle, cardiometabolic disease, and multimorbidity in a prospective Chinese study. Eur Heart J. 2021;42:3374–84. https://doi.org/10.1093/eurheartj/ehab413.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lai H, Tu Y, Liao C, Zhang S, He L, Li J. Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018. Cardiovasc Diabetol. 2025;24:109. https://doi.org/10.1186/s12933-025-02667-y.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lenfant C, Chobanian AV, Jones DW, Roccella EJ, Joint National Committee on the Prevention. Detection, evaluation, and treatment of high blood pressure. Seventh report of the joint National committee on the prevention, detection, evaluation, and treatment of high blood pressure.(JNC 7): resetting the hypertension sails. Hypertension. 2003;41:1178–9. https://doi.org/10.1161/01.hyp.0000107251.49515.c2.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Khalaji A, Behnoush AH, Khanmohammadi S, Ghanbari Mardasi K, Sharifkashani S, Sahebkar A, et al. Triglyceride-glucose index and heart failure: a systematic review and meta-analysis. Cardiovasc Diabetol. 2023;22:244. https://doi.org/10.1186/s12933-023-01973-7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lee S-H, Kwon H-S, Park Y-M, Ha H-S, Jeong SH, Yang HK, et al. Predicting the development of diabetes using the product of triglycerides and glucose: the Chungju metabolic disease cohort (CMC) study. PLoS One. 2014;9:e90430. https://doi.org/10.1371/journal.pone.0090430.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen Q, Xiong S, Zhang Z, Yu X, Chen Y, Ye T, et al. Triglyceride-glucose index is associated with recurrent revascularization in patients with type 2 diabetes mellitus after percutaneous coronary intervention. Cardiovasc Diabetol. 2023;22:284. https://doi.org/10.1186/s12933-023-02011-2.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Su W, Wang J, Chen K, Yan W, Gao Z, Tang X, et al. A higher TyG index level is more likely to have enhanced incidence of T2DM and HTN comorbidity in elderly Chinese people: a prospective observational study from the reaction study. Diabetol Metab Syndr. 2024;16:29. https://doi.org/10.1186/s13098-024-01258-3.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bian K, Hou C, Jin H, Feng X, Peng M, Zhao X, et al. Association between triglyceride-glucose indices and ischemic stroke risk across different glucose metabolism statuses. Diabetes Res Clin Pract. 2025;222:112064. https://doi.org/10.1016/j.diabres.2025.112064.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Li S, An L, Fu Z, Zhang W, Liu H. Association between triglyceride-glucose related indices and all-cause and cause-specific mortality in the general population: a cohort study. Cardiovasc Diabetol. 2024;23:286. https://doi.org/10.1186/s12933-024-02390-0.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cheng L, Zhang F, Xue W, Yu P, Wang X, Wang H, et al. Association of dynamic change of triglyceride-glucose index during hospital stay with all-cause mortality in critically ill patients: a retrospective cohort study from MIMIC IV2.0. Cardiovasc Diabetol. 2023;22:142. https://doi.org/10.1186/s12933-023-01874-9.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yan Y, Wang D, Sun Y, Ma Q, Wang K, Liao Y, et al. Triglyceride-glucose index trajectory and arterial stiffness: results from Hanzhong adolescent hypertension cohort study. Cardiovasc Diabetol. 2022;21:33. https://doi.org/10.1186/s12933-022-01453-4.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Li F, Wang Y, Shi B, Sun S, Wang S, Pang S, et al. Association between the cumulative average triglyceride glucose-body mass index and cardiovascular disease incidence among the middle-aged and older population: a prospective nationwide cohort study in China. Cardiovasc Diabetol. 2024;23:16. https://doi.org/10.1186/s12933-023-02114-w.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wong CW, Kwok CS, Narain A, Gulati M, Mihalidou AS, Wu P, et al. Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis. Heart. 2018;104:1937–48. https://doi.org/10.1136/heartjnl-2018-313005.

    Article 
    PubMed 

    Google Scholar 

  • Leung CY, Huang H-L, Abe SK, Saito E, Islam MR, Rahman MS, et al. Association of marital status with total and cause-specific mortality in Asia. JAMA Netw Open. 2022;5:e2214181. https://doi.org/10.1001/jamanetworkopen.2022.14181.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17:122. https://doi.org/10.1186/s12933-018-0762-4.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Singhal A. Endothelial dysfunction: role in obesity-related disorders and the early origins of CVD. Proc Nutr Soc. 2005;64:15–22. https://doi.org/10.1079/pns2004404.

    Article 
    PubMed 

    Google Scholar 

  • Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30. https://doi.org/10.3389/fendo.2016.00030.

    Article 
    PubMed 

    Google Scholar 

  • Domingo E, Marques P, Francisco V, Piqueras L, Sanz M-J. Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases? Pharmacol Res. 2024;200:107058. https://doi.org/10.1016/j.phrs.2024.107058.

    Article 
    PubMed 

    Google Scholar 

  • Pieri BLdaS, Rodrigues MS, Farias HR, Silveira G, de Ribeiro B, de Silveira V et al. PCL,. Role of oxidative stress on insulin resistance in diet-induced obesity mice. Int J Mol Sci. 2023;24:12088. https://doi.org/10.3390/ijms241512088

  • Fan Y, Yan Z, Li T, Li A, Fan X, Qi Z, et al. Primordial drivers of diabetes heart disease: comprehensive insights into insulin resistance. Diabetes Metab J. 2024;48:19–36. https://doi.org/10.4093/dmj.2023.0110.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang T, Li M, Zeng T, Hu R, Xu Y, Xu M, et al. Association between insulin resistance and cardiovascular disease risk varies according to glucose tolerance status: a nationwide prospective cohort study. Diabetes Care. 2022;45:1863–72. https://doi.org/10.2337/dc22-0202.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • β Cell dysfunction. during progression of metabolic syndrome to type 2 diabetes – PubMed [Internet]. [cited 2025 Jun 14]. Available from: https://pubmed.ncbi.nlm.nih.gov/31424428/https://doi.org/10.1172/jci129188

  • Petrie JR, Guzik TJ, Touyz RM. Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Can J Cardiol. 2018;34:575–84. https://doi.org/10.1016/j.cjca.2017.12.005.

    Article 
    PubMed 

    Google Scholar 

  • Oishi Y, Manabe I. Organ system crosstalk in cardiometabolic disease in the age of multimorbidity. Front Cardiovasc Med. 2020;7:64. https://doi.org/10.3389/fcvm.2020.00064.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fu J, Yu MG, Li Q, Park K, King GL. Insulin’s actions on vascular tissues: physiological effects and pathophysiological contributions to vascular complications of diabetes. Mol Metab. 2021;52:101236. https://doi.org/10.1016/j.molmet.2021.101236.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sasaki N, Itakura Y, Toyoda M. Gangliosides contribute to vascular insulin resistance. Int J Mol Sci. 2019;20:1819. https://doi.org/10.3390/ijms20081819.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

Continue Reading

  • Apple iOS 26 set to dump 75M iPhones on the e-waste pile • The Register

    Apple iOS 26 set to dump 75M iPhones on the e-waste pile • The Register

    The pending release of Apple’s iOS 26 could see around 75 million iPhones rendered obsolete, generating more than 1.2 million kilograms of e-waste globally, according to new research.

    The next major version of Cupertino’s mobile operating system is scheduled to be released this month following its announcement at WWDC in June.

    That will affect the owners of aging iPhone XR, XS, and XS Max devices, which are to be excluded from the update, according to waste management operation Business Waste. While some owners will carry on using them, the kit will gradually become outdated and many users will choose to upgrade to a new model, potentially adding to the growing pile of e-waste.

    Business Waste is rather more interested in the materials that could be recovered from scrapping those old phones, which it calculates to be worth upwards of £271 million ($363 million).

    It reckons those 75 million devices represent over 1,208,800 kilograms of copper, 1,238,944 kilograms of palladium, and 2,569 kilograms of gold. The latter is the most valuable, potentially worth in excess of £200 million ($268 million).

    The best option for any such old unsupported devices is to recycle them, the firm says, rather than letting them end up in landfills.

    “E-waste is the world’s fastest-growing solid waste stream with more than 50 million tonnes generated globally each year,” Business Waste’s Graham Matthews said.

    He pointed out that e-waste which ends up in landfills can damage the environment and even human populations as hazardous substances leak out and contaminate the surrounding area. “So, it’s especially important to ensure you recycle old devices responsibly.”

    Despite this, a report from research biz CCS Insight claimed that fewer than a third of European consumers trade in or sell their old phones. This was holding back the supply of secondhand devices that might otherwise stimulate a market for more environmentally-friendly alternatives to buying new.

    A United Nations report published last year warned about the growing threat of electronic waste, which it said is piling up five times faster than it is being recycled.

    The report called for improvements in e-waste management and for governments to introduce policies to incentivize the reuse of devices or the recycling of their component materials by industry.

    And it isn’t just smartphones that are causing the problem: the US-based Public Interest Research Group (PIRG) network warned earlier this year that the looming end-of-life date for Windows 10 (October 14) will leave up to 400 million PCs unable to upgrade to the next version because of arbitrary hardware requirements.

    PIRG has also set up an online Electronic Waste Graveyard site that lists various devices which have gone to Silicon Heaven, calculates the total weight of all the dead gadgets, and allows users to sort the list by brand, category, and the reason for their discontinuation. ®

    Continue Reading