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  • Asian shares retreat after Alphabet and AI stocks nudge Wall Street to more records

    Asian shares retreat after Alphabet and AI stocks nudge Wall Street to more records

    MANILA, Philippines — Asian shares retreated on Friday after Wall Street inched to more records as gains for Alphabet and artificial-intelligence stocks helped offset a steep tumble for EV-maker Tesla.

    Japan’s Nikkei 225 fell 0.7% to 41,511.09 after two days of gains following President Donald Trump’s announcement of a trade deal that would place a 15% tax on imports from Japan. That’s lower than the 25% rate that Trump had earlier said would kick in on Aug. 1.

    Data released on Friday showed the inflation rate in Japan’s capital Tokyo rose 2.9% year-on-year in July, down from 3.1% in June. Japanese government efforts to moderate inflation are working, though underlying Tokyo price pressures remain elevated, ING Economics said in a commentary. It expects the Bank of Japan to hold interest rates steady at its July 30-31 meeting, but said the central bank would likely raise its forecast for inflation.

    In the Chinese markets, Hong Kong’s Hang Seng shed 1.1% to 25,383.07 and the Shanghai Composite index slid 0.3% to 3,593.38.

    On Thursday, China and the European Union issued a joint call to action on climate change during an otherwise tense bilateral summit in Beijing riven with major disagreements over trade and the war in Ukraine.

    Next week, U.S. Treasury Secretary Scott Bessent has said he will meet with Chinese officials in Stockholm, Sweden, to work toward a deal with Beijing ahead of a tariff truce that expires on Aug. 12. Trump has said a China trip “is not too distant” as trade tensions ease.

    “One big question for markets is whether the tariff ceasefire is extended. We expect that an agreement will be attainable, but, in the interim, markets will watch closely to see if there are adjustments to current tariff rates in either direction,” ING Economics said.

    In South Korea, the Kospi picked up 0.3% to 3,199.91, while Australia’s S&P/ASX 200 shed 0.4% to 8,673.80.

    Taiwan’s Taiex dropped 0.1% and in India, the Sensex fell 0.1%.

    On Thursday, the S&P 500 added 0.1% to its all-time high set the day before, closing at 6,363.35. The Dow Jones Industrial Average fell 0.7% to 44,693.91, while the Nasdaq composite rose 0.2% to a record 21,057.96.

    Alphabet climbed 1% after the company behind Google and YouTube delivered a fatter profit for the latest quarter than analysts expected. It’s leaning more into artificial-intelligence technology and said it’s increasing its budget for AI chips and other investments this year by $10 billion to $85 billion.

    That helped push up other stocks in the AI industry, including a 1.7% rise for Nvidia. The chip company was the strongest single force lifting the S&P 500 because it’s the largest on Wall Street in terms of value.

    But an 8.2% drop for Tesla kept the market in check. Elon Musk’s electric-vehicle company reported results for the spring that were roughly in line with or above analysts’ expectations, and Musk is trying to highlight Tesla’s moves into AI and robotaxis.

    The focus, though, remains on how Musk’s foray into politics is turning off potential customers, and he said several rough quarters may be ahead as “we’re in this weird transition period where we’ll lose a lot of incentives in the U.S.”

    Stocks have broadly been rallying for weeks on hopes that President Donald Trump will reach trade deals with other countries that will lower his stiff proposed tariffs, along with the risk that they could cause a recession and drive up inflation.

    In other dealings on Friday, U.S. benchmark crude oil added 13 cents to $66.16 per barrel. Brent crude, the international standard, rose 12 cents to $68.48 per barrel.

    The U.S. dollar edged higher to 147.21 Japanese yen from 147.00. The euro fell to $1.1737 from $1.1748. ___

    AP Business Writer Stan Choe contributed.

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  • At least four children dead in school roof collapse in India | Infrastructure News

    At least four children dead in school roof collapse in India | Infrastructure News

    Rescue teams race to find survivors after deadly school building collapse in western India.

    At least four children have been killed and 17 others injured after the roof of a school building collapsed in India’s western state of Rajasthan, according to local reports.

    The tragedy took place on Friday morning shortly after daily prayers at a government-run school in Barmer district. Authorities say about 25 to 30 students were inside the classroom when the ceiling suddenly gave way.

    Local police believe the building’s deteriorating structure, worsened by recent heavy rainfall, may have caused the collapse. “Some of the injured are in critical condition,” senior police officer Amit Kumar told the Press Trust of India.

    Rajasthan’s education minister, Madan Dilawar, said he had instructed officials to oversee the medical treatment of the injured and ensure families receive support. “I have directed the authorities to make proper arrangements and to oversee the injured children’s treatment, and to ensure they do not face any kind of difficulties,” he told AajTak news channel.

    Dilawar added that a formal investigation would be launched to determine the exact cause. “I have also spoken to the collector and directed authorities to take stock of the situation and help in whatever way possible,” he said.

    Footage broadcast on Indian television showed locals and emergency workers using cranes to clear debris as anxious parents looked on. The sound of relatives wailing could be heard near the site.

    Rescue efforts were ongoing late into the day. Local media said 32 students had been pulled out alive so far, though some were severely injured.

    “Instructions have been given to the concerned authorities to ensure proper treatment for the injured children,” Rajasthan Chief Minister Bhajanlal Sharma said in a statement on X.

    Rajasthan, known for its extreme weather, has experienced intense monsoon rains in recent weeks, raising concerns over the safety of ageing infrastructure in rural schools.

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  • New study uncovers how prior obesity impacts viral consequences

    New study uncovers how prior obesity impacts viral consequences

    A study comparing the effects of SARS-CoV-2 infection in lean and obese primates found different long-term consequences of the virus depending on prior obesity and metabolic disease. The results, which also highlighted how widespread long COVID symptoms are in animals, were published July 24th in the open-access journal PLOS Pathogens by Charles Roberts of Oregon Health & Science University, USA, and colleagues.

    Long-term adverse consequences of SARS-CoV-2 infection, termed “long COVID” or post-acute sequelae of COVID (PASC), are a major component of the overall COVID-19 disease burden. Prior obesity and metabolic disease are known to increase the severity of acute disease, but SARS-CoV-2 infection also contributes to the development of new-onset metabolic disease.

    In the new study, researchers studied the effects of infection with the SARS-CoV-2 delta variant in lean as well as obese and insulin-resistant adult male rhesus macaques over a 6-month time course. The majority of animals had consistently altered parameters months after the resolution of initial infection. Levels of virus in the respiratory system, viral antibodies, and inflammatory factors in the blood were generally similar between lean and obese animals.

    Other responses varied by metabolic status. While obesity increased risks like persistent lung damage and longer-term weight loss, lean animals were more likely to develop signs of metabolic disruption.

    Notably, lean animals experienced a significant decline in the ratio of the blood concentration of the hormone adiponectin to that of the hormone leptin, thereby lowering their level of this metabolic health marker to the level seen in obese peers.Because many long-term effects were physiological rather than symptomatic, the study suggests long COVID may be more common than human self-report data indicates.

    “Some parameters changed more robustly in obese animals, while others changed more robustly in lean animals. Thus, persistent effects of SARS-CoV-2 infection are both obesity-dependent and independent,” the authors say.

    “I think one of the most striking results of our study was the extent of long-term adverse effects seen after a what outwardly appeared to be a very mild initial disease course. This suggests that long COVID can indeed result from a mild infection.”


    Charles Roberts, Professor, Oregon Health & Science University

    Dr. Roberts adds, “Since we saw increased levels of inflammatory factors and changes in biomarkers of cardiometabolic disease risk 6 months after infection, some symptoms of long COVID may only become apparent long after the initial infection.”

    Coauthor Dr. Kristin Sauter notes, “Our development of a macaque model of long COVID will allow us to directly compare the intrinsic differences between the effects of the delta variant described in this study with the effects of later variants such as omicron, which is the subject of our current NIH-supported work.

    This is possible because the macaques used in our studies have never been exposed to the SARS-CoV-2 virus previously, so any different responses can be attributed to differences in the variants themselves, rather than being due to varying levels of existing immunity, which complicate human studies.”

    Source:

    Journal references:

    Sauter, K. A., et al. (2025). Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates. PLOS Pathogens. doi.org/10.1371/journal.ppat.1012988

     

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  • New method uses magnetism for targeted drug delivery

    New method uses magnetism for targeted drug delivery

    Researchers have demonstrated that microscopic drug delivery containers can be magnetically steered to their targets, advancing the development of precision medicine for treating diseases such as cancer.

    A multi-university team led by Jie Feng, a professor of mechanical science and engineering in The Grainger College of Engineering at the University of Illinois Urbana-Champaign, demonstrated that magnetic particles encapsulated in lipid vesicles can be used to steer the vesicles through fluids.

    This work, published in the Royal Society of Chemistry journal Nanoscale, builds on earlier results showing that lipid vesicles can be engineered to release drugs when illuminated with laser light. The resulting system, combining both results, is a comprehensive prototype for precision and targeted drug delivery.

    “The appeal of lipid vesicles for drug delivery is that their structure is similar to a cell, so they can be made to interact only with particular kinds of cells – a significant advantage for cancer treatment. One of the challenges to realizing such vehicles is knowing how to steer them to the correct site. We have shown how to do this using magnetic fields, solving the last big problem before we begin demonstrations ex vivo.”


    Jie Feng, Professor, Mechanical Science and Engineering, The Grainger College of Engineering, University of Illinois Urbana-Champaign

    Feng noted that existing medical technologies such as MRI could be repurposed to steer drug delivery vehicles with their magnetic fields, especially since these fields are designed to penetrate the human body. This can be achieved by encapsulating a superparamagnetic particle within the drug delivery vehicle, so it interacts with the externally controlled magnetic field.

    The first step in creating magnetically steerable lipid vesicles was developing a reliable method to encapsulate magnetic particles in the vesicles. Vinit Malik, an Illinois Grainger Engineering graduate student in Feng’s laboratory and the study’s lead author, used the method of “inverted emulsion,” in which magnetic particles are added to a solution of dissolved lipids, leading to lipid droplets forming around the particles.

    “It was not obvious what the best way to encapsulate lipid particles would be, so there was a large literature search and some trial and error,” Malik said. “We had to determine what the best magnetic particle size is, and then we had to figure out that the inverted emulsion method has the highest yields for encapsulated particles.”

    Next, the researchers demonstrated that magnetic fields could direct the lipid vesicles. Malik developed a 3D-printable platform to mount the magnets securely on a microscope and to place the vesicles in a solution between the magnets. By observing the resulting motion, the researchers observed how speed varied with the ratio of magnetic particle size to vesicle size. They also confirmed that the vesicles only release their cargo when illuminated with laser light after moving to the end of the microfluidic channel.

    While these experiments showed that the lipid vesicles moved as expected in magnetic fields, it was necessary to also understand how the magnetic particle pushes the vesicle from within to understand the behavior of the whole device.

    The Illinois researchers partnered with investigators at Santa Clara University to computationally study the internal dynamics of the vesicle to predict the motion speed. Using the lattice Boltzmann method, they observed how the magnetic particle drags the whole vesicle when moving through a magnetic field.

    “It allowed us to expand on our experiments, since it is otherwise difficult to observe or predict the response of such a vesicle system,” Malik said. “It gives us predictive power that will enhance design guidelines and allow us to understand the physical mechanisms governing the motion.”

    Armed with experimental demonstrations of light-induced drug release and magnetic steering, Feng’s laboratory now aims to begin in vitro studies demonstrating that the lipid vesicles can be magnetically steered to specific locations through fluids like human blood.

    “Our combined results lay the foundation for a comprehensive precision drug delivery system, and we’re ready to explore the potential uses in treatment,” Feng said. “We’re working towards the next step: using a real drug and performing an in vitro study in a microfluidic system that simulates features of biological environments.”

    Source:

    University of Illinois Grainger College of Engineering

    Journal references:

    Malik, V. K., et al. (2025). Magnetically driven lipid vesicles for directed motion and light-triggered cargo release. Nanoscale. doi.org/10.1039/D5NR00942A

     

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  • In-depth look at breast tumor growth and surgical delay effects

    In-depth look at breast tumor growth and surgical delay effects

    Using a novel method to analyze tumor growth rates, researchers at Fox Chase Cancer Center have provided the most in-depth assessment to date of how fast breast cancers grow in patients and how surgical delays may affect breast cancer staging, which measures the extent of cancer spread in the body. The newly published study offers new insight into how tumors progress in the time between diagnosis and surgery.

    “It is the first study ever to use pathologic tumor sizes to determine how fast tumors of different sizes and traits grow in the patient while they’re waiting for treatment.”


    Richard Bleicher, MD, FACS, Study Lead Author and Chief, Division of Breast Surgery, Fox Chase Cancer Center

    Pathologic tumor size refers to the size of a tumor after it is surgically removed from the patient and examined. Clinical size, which is determined by imaging equipment such as X-rays or CT scans before surgery, is typically less accurate.

    “Patients who are diagnosed with breast cancer are always worried about how fast breast cancer grows while they wait for their surgery and the likelihood that it will spread from that growth,” Bleicher said. “This study finally gives patients and their physicians that information for tumors of different sizes and types to make the best decisions they can.”

    The study, which Bleicher conducted with several colleagues at Fox Chase, found that the upstaging rates associated with delays are still relatively small and consistent with prior data showing that even months-long delays between diagnosis and surgery result in only single-digit mortality risks. Upstaging refers to when a patients localized cancer spreads to other parts of the body.

    “Many patients fear that delays in care will allow their cancer to grow and spread beyond the point of cure. This study provides the most comprehensive evaluation of how treatment delays may affect the likelihood that a tumor will be upstaged or be at a more advanced stage at the time of surgery than initially estimated at diagnosis,” Bleicher said.

    The research team used the differences between the initial clinical tumor size and the pathologic tumor size to calculate growth and upstaging risk between diagnosis and surgery. Accounting for inaccuracies in clinical staging, this method more accurately demonstrates the associated risks of tumor growth and progression.

    The study utilized data from the National Cancer Database for over one million patients treated between 2010 and 2020. These patients had non-metastatic, non-inflammatory breast cancer and were undergoing surgery as their first treatment.

    “Interestingly, a significant proportion of the observed upstaging is not from tumor progression, but from the inaccuracy of clinical staging. In other words, when breast cancers are upstaged at surgery, it’s more likely because we didn’t appreciate the initial extent of disease than because the tumor had time to spread,” said Bleicher.

    “The findings in this study expand our knowledge and offer new data to help counsel individuals diagnosed with breast cancer. As we continue to refine our diagnostic tools and clinical assessments, we will reduce the risk of upstaging even further,” he added.

    “We may not be able to stop time, but armed with this new knowledge, we can use it more wisely, empowering patients to ensure that they feel urgency and not fear.”

    Source:

    Temple University Health System

    Journal references:

    Bleicher, R. J., et al. (2025). Breast Cancer Upstaging Risk and In Vivo Tumor Growth Rates Associated with Preoperative Delays. Annals of Surgical Oncology. doi.org/10.1245/s10434-025-17867-9

     

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  • Breakthrough sensor tech uncovers slow-motion quakes beneath New Zealand

    WELLINGTON, July 25 (Xinhua) — Advanced seismic sensor technology is now deployed to study New Zealand’s Hikurangi Subduction Zone, revealing insights into slow-slip earthquakes.

    Scientists have installed advanced borehole sensors off New Zealand’s east coast to monitor frequent slow-slip events and potential large quakes in the Hikurangi Subduction Zone.

    The sensors detect slow-slip earthquakes, seismic events releasing energy over days or weeks, that play a key role in building and releasing tectonic stress along major faults, according to a statement released by Earth Sciences New Zealand (ESNZ).

    “It’s like a ripple moving across the plate interface,” the statement said, quoting Josh Edgington of the University of Texas Institute for Geophysics in the United States, who led the project with Charles Williams, ESNZ geodynamic modeler.

    New data from the Hikurangi Subduction Zone, expected later this year, may reveal more about slow-slip earthquakes and their role in the quake cycle, aiding hazard assessment of major faults in the active Pacific Ring of Fire, the ESNZ said. Enditem

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  • Bilateral House Flap Anoplasty for Severe Anal Stenosis: Our Experience at a Tertiary Care Center in India

    Bilateral House Flap Anoplasty for Severe Anal Stenosis: Our Experience at a Tertiary Care Center in India


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  • All you need to know about Wuyang in Overwatch 2: Abilities, perks and more | Esports News

    All you need to know about Wuyang in Overwatch 2: Abilities, perks and more | Esports News

    (Image via Blizzard Entertainment)

    Overwatch 2 is about to bring a new wave with a new Support hero, Wuyang. The character, since its announcement, has been the center of speculation and leaks. While Blizzard Entertainment has not officially confirmed all things, the revelations are offering a solid look at Wuyang’s abilities, unique perks and weapons. Here is all we know so far about him.

    Wuyang Overwatch 2 abilities and weapons

    The core kit of Wuyang, Overwatch 2 new support hero revolves around the manipulation of water for aid and offense. Wuyang primary weapon is Xuanwu Staff— the fire-damaging water orbs. Players can hold fire to guide the path of the orb and charge it for a much bigger explosion. For healing, Wuyang’s alt-fire Restorative Stream places steady healing on an ally. To hold the button would intensify the healing but consume dedicated resources.Wuyang’s active abilities help enhance mobility and team support. Guardian Wave sends forth the water surge. It can boost healing that’s received by allies it touches, while it can forcefully knock down the enemies. On the other hand, the passive abilities of Wuyang help to regenerate health quickly.To reposition, Rushing Torrent allows Wuyang to surf the wave and gain a significant amount of jump height and speed. Tidal Blast, Wuyang ultimate ability, further encases him or the ally in the protective water. The bubble shortly after explodes, as it knocks down the nearby foes and delivers massive healing to the protected target.

    Wuyang perks and playstyle offering strategic advantages

    Beyond base abilities, leaked perks further added depth to Wuyang’s playstyle. Some minor perks provide tactical boosts. Like Overflow can instantly refill ammo and healing resources when Rushing Torrent gets used. Balance, on the other hand, rewards aggression, ensuring to damage enemies using water orbs, temporarily and increasing passive healing using Restorative Stream.Some major perks that significantly help alter the ability function. Like, Ebb and Flow can make Guardian Wave automatically return to the origin point, after they have reached the end. However, it does deal with less damage on the return trip.Falling Rain further transforms Wuyang’s primary fire. It allows simultaneous better control of 3 weaker water orbs for having wider area pressure, but with the reduced individual impact. All these perks suggest rewarding players who can master the positioning and ability combos.The leaked design of Wuyang points to high-mobility and dynamic Support that’s focused on the burst healing windows and disruption of enemy positioning. The reliance of Wuyang on resource management and the perk choices further promise a high skill ceiling. While the Overwatch 2 trial dates are soon (August 14, 2025, to August 18, 2025), the Blizzard Entertainment hero leaks offers a clear picture of the new aquatic hero in Overwatch 2.


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  • BBVA completes its first venture debt transaction in Germany with Roadsurfer for €25 million

    BBVA completes its first venture debt transaction in Germany with Roadsurfer for €25 million

    This agreement benefits from the support of the European Union and the European Investment Fund (EIF) under the InvestEU program, enabling the establishment of more favorable conditions for both parties and delivering a financing solution tailored to the company’s specific needs.

    “Roadsurfer represents the type of company BBVA wants to support: digital, innovative, and committed to fostering more sustainable ways of traveling and consuming. Its growth reflects the dynamism of the European entrepreneurial ecosystem and our commitment to providing flexible financial solutions to internationally ambitious companies,” said Donatella Callegaris, Head of Venture & Growth Lending at BBVA in Europe.

    “These financing rounds reflect our partners’ confidence in our business model. The collaboration with BBVA was marked by constructive dialogue and a shared understanding of long-term value creation,” noted Markus Dickhardt, co-founder and CEO of Roadsurfer.

    Founded in 2016, Roadsurfer has established itself as one of the most recognized brands in the camper van rental sector. It currently operates a fleet of nearly 10,000 vehicles and is present in more than 90 locations across 16 countries, including Germany, Spain, France, Portugal, the U.S., and Canada. Its offering includes rental, subscription, and sales services for camper vans, in addition to its “Roadsurfer Spots” platform, which connects travelers with private landowners for camping.

    A complementary transaction aligned with its financing strategy

    The financing provided by BBVA complements a previous €60 million asset-backed securitization (ABS) operation led by Macquarie Group, bringing Roadsurfer’s total financing capacity to over €500 million.

    Both transactions reflect the company’s comprehensive capital strategy, focused on strengthening its fleet, consolidating key markets, and continuing to develop digital solutions that make camper travel more accessible, sustainable, and appealing.

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  • Stereotactic Radiosurgery and Fractionated Stereotactic Radiotherapy With a Linear Accelerator (LINAC) for Acromegaly Remission: Clinical Experience From a Tertiary Neurological Center in Latin America

    Stereotactic Radiosurgery and Fractionated Stereotactic Radiotherapy With a Linear Accelerator (LINAC) for Acromegaly Remission: Clinical Experience From a Tertiary Neurological Center in Latin America


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