Van Andel Institute scientists have developed an improved technique to comprehensively profile DNA methylation in single cells, an advance that will help researchers better study the role of epigenetics in cancer and other diseases.
DNA methylation is an epigenetic mechanism that influences how and when the instructions in DNA are used without changing the DNA sequence itself. As a result, DNA methylation is a key player in many fundamental biological processes including development, gene expression and cell differentiation. Methylation errors are well-known contributors to cancer and have been implicated in a host of other disorders.
The new method, called scDEEP-mC, yields very high-resolution maps of DNA methylation and is the most efficient single-cell DNA methylation technique developed to date. Scientists can use scDEEP-mC to reveal powerful new insights into single-cell biology and identify differences that set rare cell types apart from other cells. scDEEP-mC also supports many cutting-edge analyses in single cells, including estimation of cellular age using epigenetic clocks, analysis of hemimethylation and creation of whole-chromosome X-inactivation epigenetic profiles.
A study describing scDEEP-mC was recently published in the journal Nature Communications. VAI’s Peter W. Laird, Ph.D., and Hui Shen, Ph.D., are co-corresponding authors.
“scDEEP-mC allows us to see DNA methylation at varying stages of DNA replication in individual cells – something that has not been possible until now,” said Nathan Spix, Ph.D., co-first author of the study and a postdoctoral fellow in the Laird Lab. “For example, scDEEP-mC can help us pinpoint early DNA methylation changes in single cells that go on to become cancerous. If we know what goes wrong in the early stages of this process, we can use that information to develop new ways to detect and treat disease.“
Because of technical limitations, other DNA methylation analysis methods do not allow for direct comparisons between cells. Instead, they require scientists to average signals from groups of cells, obscuring important but subtle differences between individual cells. scDEEP-mC’s high-resolution data enables scientists to more effectively identify cell subtypes, methylation patterns and other important features such as differences between older cells and newly replicated cells.
Source:
Van Andel Research Institute
Journal reference:
Spix, N. J., et al. (2025). High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics. Nature Communications. doi.org/10.1038/s41467-025-61589-1.
Optus Sport customers who paid an annual fee for the service will receive a refund when it shuts down next month – but only by cheque in some cases.
Optus announced on 30 June its sport streaming service would close on 1 August, after it transferred the rights to broadcast the Premier League, FA Cup and other competitions to Nine Entertainment and Stan.
In an email to customers on Monday – seen by Guardian Australia – Optus said eligible customers would need to provide their postal and email address by 29 August to get a refund on the unused portion of their $199 annual subscription.
“We can only issue your refund via a cheque,” the email said.
A spokesperson for Optus said a “subset group” of customers had been told their refund would be issued via cheque.
“This is not the standard practise and is occurring where electronic banking is unavailable due to our billing and subscription management system constraints or where the credit card has been cancelled, expired or failed,” they said.
In 2023 the government announced that cheques would be phased out in a “gradual, coordinated and inclusive” transition to purely digital payment services, after a 90% decline in the use of cheques over 10 years.
One former Optus customer commented on X: “Cheque refund @OptusSport … what sort of medieval transaction is this. Havnt been to a ye old bank for years.”
In a February 2024 submission to the government’s consultation process on the transition away from cheques, Optus noted there were “limited circumstances” where cheques were still used.
“Cheques remain beneficial where a large volume of payments is required to be made, particularly where such payments are unable to be provided via the original payment method (for example, for former customers or where details are no longer current) …
“In addition, cheques remain a secure way of providing payments without needing to contact customers / former customers and requesting updated financial details. This is important in an environment where Government and organisations are taking steps to reduce and disrupt scam activity.”
In November 2024 the government confirmed that cheques could no longer be issued after 28 June 2028, and would not be accepted after 30 September 2029.
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A spokesperson for the Australian Competition and Consumer Commission said consumer law did not specify what method should be used for refunds.
“However, businesses that use cheques to provide customers with refunds should be planning for how they will transition to other payment methods in line with the government’s transition plan for the phasing out of cheques,” the spokesperson said.
“Businesses should also consider ways to ensure that their customers are actually able to receive any refunds, particularly consumers in remote areas with less access to banking facilities.”
The digital policy director at the Consumer Policy Research Centre, Chandni Gupta, said digital products had a clear path between product and payment – if money came in one way, it should be returned the same way.
“Placing the onus on individuals to go through extra steps to claim a refund that is rightly theirs creates an unnecessary barrier for someone who has already lost time and money,” Gupta said.
“It’s unfair for customers to have to jump through hoops to access their refund, but sadly it’s not illegal.”
The director of legal practice at the Consumer Action Law Centre, Stephen Nowicki, said he generally did not see a problem with refunding money via cheque, and it might even be preferable to reduce the potential for scams.
“But if somebody prefers to get an online refund then I would hope Optus Sport gives them that option,” Nowicki said.
A landmark study published in Cell has unveiled a first-of-a-kind optogenetic screening platform, developed by scientists at Integrated Biosciences, a biotechnology company integrating optogenetics, chemistry and AI to discover small molecule therapeutics for age-related diseases. The new peer-reviewed publication demonstrates the platform’s capabilities by applying it to the integrated stress response (ISR), a key aging- and disease-associated signaling pathway implicated in neurodegeneration, cancer and viral infection.
In the Cell study, Integrated Biosciences scientists used optogenetic control to selectively activate the ISR, leading to the discovery of several ISR-potentiating compounds that sensitize stressed cells to apoptosis without inducing cytotoxicity across diverse cell types and stressors – an elusive therapeutic profile not achievable with traditional ISR drugs in development. The lead compounds identified in the study showed broad-spectrum antiviral activity in vitro, and one compound significantly reduced disease pathology and viral titers in a mouse model of ocular herpesvirus infection.
The versatile platform that is featured in the study allows for precise and dynamic control of biological targets and processes, unlocking a powerful new approach to drug discovery. By integrating programmable, light-responsive domains with automated high-throughput screens, the platform interrogates biological systems with millisecond temporal precision and micron-scale spatial resolution. This uniquely modular system allows researchers to resolve compound effects in real time, across diverse targets, cell types, and disease-relevant contexts, providing a level of precision and control not achievable with conventional screening technologies.
Synthetic biology tools like optogenetics allow us to precisely tune complex cellular processes, something traditional drug screening cannot do. Our platform lets us activate specific targets and pathways with light, generating clean, interpretable readouts and the discovery of high-precision compounds, often with unprecedented mechanisms of action, that were previously inaccessible.”
Maxwell Wilson, Ph.D., Co-Founder and Chief Scientific Officer of Integrated Biosciences
Unlike traditional perturbation agents and pharmacological tools, the platform enables selective, pathway-specific activation without the off-target or systemic confounding effects, generating clean, high-fidelity, on-pathway datasets. This is especially critical in phenotypic screening and AI-driven discovery where data quality remains a major bottleneck to extracting meaningful insights.
“This work by the team at Integrated Biosciences is a powerful demonstration of how synthetic biology can reshape therapeutic discovery,” said James J. Collins, Ph.D., Scientific Co-Founder and Chair of the Scientific Advisory Board at Integrated Biosciences, and Termeer Professor of Medical Engineering and Science at MIT. “Using this novel platform, Integrated Biosciences can now interrogate disease-relevant biology and systematically explore chemical space with a level of nuance and specificity that was previously out of reach.”
Beyond the ISR, Integrated Biosciences’ optogenetic platform offers a generalizable strategy for discovering small molecules that modulate complex, traditionally hard-to-drug targets and pathways, including those central to aging. Because the system is modular and tunable, it can be rapidly adapted to explore a wide range of biological processes with on-pathway, on-phenotype precision – a major advantage over traditional screening tools.
“This is only the first demonstration of what our optogenetic platform can do,” said Wilson. “Synthetic biology gives us the control we need to build more accurate, disease-relevant discovery systems. Our goal is to bring this level of precision to other pathways where conventional tools have failed.”
This work further strengthens the company’s AI-driven discovery engine, which leverages graph neural networks – an architecture the team helped pioneer through foundational studies published in Nature, Nature Aging and Nature Protocols. Together, these advances position Integrated Biosciences at the forefront of a new era in drug discovery, where high-fidelity data and sophisticated computational modeling converge to unlock previously inaccessible therapeutic opportunities.
Source:
Journal reference:
Wong, F., et al. (2025). Optogenetics-enabled discovery of integrated stress response modulators. Cell. doi.org/10.1016/j.cell.2025.06.024.
Police in India have arrested a man in connection with the death of Fauja Singh, the world’s oldest marathon runner, in a hit-and-run case.
According to the police, the accused, Amritpal Singh Dhillon was driving a speeding SUV when he struck the 114-year-old British-Indian runner. Singh sustained critical injuries and died shortly after being taken to hospital.
The incident took place in the northern state of Punjab on Monday, where Singh was out on his afternoon walk.
Singh, a global icon, set records by running marathons across multiple age categories, including when he was over 100. He began running at 89 and ran nine full marathons between 2000 and 2013, when he retired.
A white-coloured SUV, allegedly used in the incident, has also been recovered by the police.
The hit and run occurred near Fauja Singh’s birth village of Beas Pind, close to Jalandhar city.
Police said Singh was crossing a road when he was struck by a vehicle. Locals rushed him to hospital, where he later died.
According to Indian media reports citing the police complaint, the runner’s life might have been saved had the 26-year-old driver immediately taken Singh to the hospital.
Singh had many records to his name.
In 2011, he reportedly became the first person over 100 to finish a full marathon, in Toronto. He also carried the Olympic torch at the 2012 London Olympics.
Despite his achievements, Guinness World Records could not recognise him as the oldest marathon runner because he did not have a birth certificate from 1911.
The BBC earlier reported that Singh’s British passport showed his date of birth as being 1 April 1911, and that he had a letter from the Queen congratulating him on his 100th birthday.
Guinness said they wanted to give him the record but could only accept official documents from the year of birth.
His marathon trainer had earlier said that birth certificates were not issued in India at the time.
His running club and charity, Sikhs In The City, said its upcoming events in Ilford, east London, where he had lived since 1992, would be a celebration of his life and achievements.
As a young boy, Singh was often teased in his village in Punjab because his legs were weak. He couldn’t walk properly until the age of five.
“But the same boy, once mocked for his weakness, went on to make history,” he told BBC Punjabi in June.
Singh never went to school and didn’t play any sports growing up. He worked as a farmer and lived through both World Wars and the turbulent partition of India.
“In my youth, I didn’t even know the word ‘marathon’ existed,” he said.
He started running much later in life, after going through deep personal loss.
In the early 1990s, after his wife died, Singh moved to London to live with his eldest son. But during a visit to India, he witnessed his younger son Kuldeep’s death in an accident, which left him devastated.
Back in the UK, Singh was overtaken by grief. One day, during a visit to the local gurdwara in Ilford, he met a group of older men who went on regular runs. That’s where he also met Harmander Singh, who later became his coach and his journey as a runner began.
Singh shot to international fame when Adidas signed him for their 2004 Impossible is Nothing advertising campaign, which also featured legends such as Muhammad Ali.
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New Trains on the Sengkang-Punggol LRT (Photo courtesy of SBS Transit LTD)
Tokyo, July 16, 2025 – Mitsubishi Heavy Industries, Ltd. (MHI) has completed delivery of the first trains for a project to enhance the transport capacity of the Automated Guideway Transit (AGT) system(Note1) used on the Sengkang-Punggol Light Rapid Transit (SPLRT)(Note2) network serving the northeast area of Singapore, based on an order received jointly with MHI’s regional subsidiary Mitsubishi Heavy Industries Asia Pacific Pte. Ltd. (MHI-AP) and Mitsubishi Corporation (MC) in 2022 from the Land Transport Authority (LTA) of Singapore.(Note3)
First two new trains were delivered and began commercial operation on July 15. On the same day, LTA hosted a ceremony to commemorate the commencement of commercial operations, attended by Singapore’s Deputy Prime Minister Gan Kim Yong. MHI group will plan for sequentially deliver a total of 25 trains by 2028.
The new trains retain the similar exterior design as the existing trains. In addition, our married-pair trains have achieved optimization of onboard equipment such as signaling system. The driver’s cab inside the vehicle is equipped with a touch panel that allows settings to be adjusted for each piece of equipment. Further, MHI responded to various requests from the operator for improvements, such as continually accumulating vehicle information during operation and utilizing this data to enhance the speed of maintenance and troubleshooting.
The population of the Sengkang and Punggol areas is growing rapidly, and the number of users of the SPLRT is increasing. Expectations for this project are high among the people involved and the surrounding residents. MHI based on their track record of stable operation and after-sales service since the start of operations, will steadily implement the project.
MHI Group will continue to contribute to the world through services that support the comfortable and safe transport of people and goods.
1Automated Guideway Transit (AGT) is an electric power-driven, fully automated transportation system. A key feature is the rubber-tired carriages that provide a smooth ride with low noise. AGT is used around the world for intra-city transportation, and moving people through airports and to surrounding areas.
2Conventionally, LRT is used as the abbreviation of “Light Rail Transit,” but in the case of Singapore’s Sengkang-Punggol LRT, the “R” refers to “Rapid” in accordance with that network’s high-speed operation.
3For more information on the Sengkang-Punggol LRT transport capacity enhancement project, see the following press releases. https://www.mhi.com/news/220217.html https://www.mhi.com/news/23050901.html
About Mitsubishi Heavy Industries Asia Pacific Pte. Ltd. (MHI-AP) Mitsubishi Heavy Industries Asia Pacific Pte. Ltd. (MHI-AP) is a subsidiary of Mitsubishi Heavy Industries, Ltd. (MHI), one of the world’s leading industrial firms. Located in Singapore, the Asia Pacific headquarters supports the growth of markets in Singapore, Malaysia, Thailand, Indonesia, Philippines, Vietnam, India, Australia and other parts of the region. MHI-AP builds on its global outlook and deep local insights to deliver integrated solutions to the region in urban development and infrastructure, energy and utilities, as well as logistics and transportation. As a market leader in Asia Pacific, MHI-AP provides reliable and innovative solutions that move the world forward. For more information, visit www.mhi.com/.
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Brown hyenas are reported to be housed in only two zoos in the UK
A young pair of one of the world’s rarest carnivores has arrived at a Cornish zoo.
Newquay Zoo said it was the only zoo in the south-west of England and one of two zoos in the UK to house endangered brown hyenas, also known as strandwolves.
Flo and Quinn, a sibling pair aged just under two years old, arrived from Hamerton Zoo Park in Cambridgeshire on Wednesday.
Newquay Zoo’s curator of plants and animals John Meek said: “For people to be able to see them up close is a powerful reminder of why zoo conservation matters.”
Helen Black Photography
Mr Meek says Quinn is one of the rarest species of hyena
“They are one of Africa’s least understood carnivores – shy, solitary and beautifully adapted for survival in some of the toughest environments on Earth,” he added.
He said brown hyenas (Parahyaena brunnea) were the rarest of the four hyena species, with as few as 5,000 estimated to remain in the wild, in southern Africa.
Mr Meek explained the species played “a crucial role in maintaining ecosystem health as nature’s clean-up crew” because they ate carcasses that prevented disease spread and helped recycle nutrients back into the environment.
Helen Black Photography
Flo is one of the sibling pair moved from Hamerton Park Zoo
He described brown hyenas as “perfectly adapted scavengers”, which ate almost every part of a carcass, including bone, while also supplementing their diet with fruit, eggs and insects.
Flo and Quinn had been housed in the old lion enclosure, he added, where their habitat included shelter areas, naturalistic landscaping and space for enrichment opportunities to encourage natural behaviours.
Stuart Spray, here using the VR equipment at Torbay Hospital, says he is feeling a lot healthier than he did before
A hospital in Devon has been demonstrating new technology which is helping patients manage long-term chronic pain in a different way from medication alone.
The virtual reality (VR) immersive therapy at Torbay Hospital involved patients stepping into another world and moving in ways where they were not concentrating on the pain, staff said.
The Torbay and South Devon NHS Foundation Trust has been offering the therapy to patients as an eight-week course.
Some patients who had been using the VR system by Cureo said they had seen in improvement in the way they moved and had reduced their pain medication.
Physiotherapist Phillipa Newton-Cross, the service lead for the pain rehabilitation team, said: “Working with pain is like trying to work with a central nervous system that is on high alert and hot-wired and alarmed all the time.
“It’s really difficult to move when you are like that.”
Physiotherapist Phillipa Newton-Cross said the nervous system was “on high alert and hot-wired and alarmed all the time”
“Learning these smooth calming skills allows you to work with your pain system less in a high alert fight-or-flight response.
“That’s enough that you’ll find that they [patients] can then manage to do better with conventional exercise.”
The team was awarded £29,000 from the NHS trust’s League of Friends to support a clinical rehabilitation pathway using virtual reality technology.
David Malpas is a patient with progressive myopathy who has problems moving his neck. He has completed an eight-week programme of therapy sessions.
He said: “It enabled me to move my body in different ways that I didn’t know how to.
“I can’t look left and right because of my neck being so pinned up and the pain.
“They managed to work out some different muscles in my body that I can use. So I can turn my body left and turn my body right.
His wife Claire said: “When we first started, I thought: ‘It’s no going to do much.’
“But, after eight weeks and the input from all of the staff at the unit, the progression to moving more easily was astounding.
“I couldn’t believe what I was seeing.”
Patient David Malpas and his wife Claire at Torbay Hospital
Stuart Spray has chronic pain and has been taking painkillers for 23 years, ending up on the highest dose of codeine that could be prescribed.
Since attending the sessions, he said he had stopped taking codeine and was feeling a lot healthier than before.
He said: “My mind has to be occupied; that’s the way am, I have to be analysing constantly.
“When I put one of these headsets on, I just disappear. I’m more concerned about me now than solving the problem.
I came off codeine three months ago completely.”
Since its introduction, 50 patients have used the system in south Devon.
This particular software has been available in other countries since 2017, but Torbay’s pain team is understood to be the first to use it in the UK.
This report is from this week’s CNBC’s UK Exchange newsletter by Ian King. Like what you see? You can subscribe here.
The dispatch
England, Napoleon Bonaparte reputedly once said, is a nation of shopkeepers.
These days, he might observe that it is more a nation of administrators, insolvency practitioners and restructuring advisors.
Barely a day passes without news of another retailer going bust or closing dozens of stores.
To take a handful of headlines from the last week: advisors have been appointed to salvage part of Claire’s U.K., the British arm of the global accessories chain, which has 281 outlets nationwide; Hamleys, the world famous U.K. toy retailer, has closed 29 stores after shutting 40 in 2023; and Seraphine, the maternity retailer whose customers included the Princess of Wales, has stopped trading altogether.
They are just the tip of the iceberg. Poundland, recently offloaded for just £1 by its Polish-listed former parent Pepco to the U.S. investment group Gordon Brothers, is widely expected to close dozens more stores on top of those already announced as its restructuring begins in earnest. Hobbycraft, the arts and crafts retailer, and the Original Factory Shop, a general retailer, are both closing scores of outlets following their acquisition by Modella Capital, the U.K. private equity firm currently in the process of buying the high street arm of WH Smith, the stationery retailer now best known for its outlets in airports around the world. Some of its branches are also likely to shut.
British retail faces a reckoning as 232-year-old chain looks to sell its high street stores
The pain is being felt most acutely in fashion retail, reflecting increased competition from online competitors like ASOS and Shein.
New Look, which has delighted generations of teenagers and 20-somethings for 55 years, is fighting for its life and earlier this year announced plans to shut 100 outlets, around a quarter of its total, when their leases expire.
The even-older River Island — which dates back to 1948 and, in the swinging 1960s, rebranded itself Chelsea Girl as it rode the mini-skirt boom — has also called in advisors to help with a possible restructuring. It currently employs some 5,500 people across more than 250 stores.
They follow a long line of well-known U.K. retailers to have closed their doors during the last decade or so — some still soldiering on as online-only brands — including Topshop, Dorothy Perkins, Ted Baker, Thorntons, Carpetright, Paperchase and Debenhams. Others, such as the Body Shop and Wilko, are under new owners, which tends to come with a vastly reduced store estate.
The retail sector is not alone in suffering. Hospitality is also afflicted with even established names like Byron Burger, Chipotle, Frankie & Benny’s and Papa John’s closing sites across the U.K. The most recent casualty was Ping Pong, a popular dim sum chain, which closed for good last week after 20 years in business. There may also soon be closures at Côte, a brasserie chain which once had 100 outlets, whose private equity investors are now seeking new investment.
In all, around 17,350 retail sites are expected to shut down this year, with the loss of almost 202,000 jobs, according to the Centre for Retail Research, a data provider. It estimates that, during 2024, some 13,479 stores closed, following 10,494 closures during 2023. To say the trend is accelerating is both accurate and worrying.
A perfect storm
There are several short-term reasons for this carnage and plenty of long-term ones.
The most important of the former is the rise in employers’ National Insurance Contributions (NICs), a payroll tax, introduced by Chancellor Rachel Reeves in April this year. However, more damaging than the increase in the rate — which rose from 13.8% to 15% — was a drop in the threshold at which it is paid from £9,100 to £5,000. That has increased the cost of employing people and, in particular, the part-time workers crucial to retail and hospitality.
A number of employers have blamed it for both job losses and branch closures.
British businesses pile on the pressure on UK Financial Minister Reeves ahead of budget update
Among them was Bob Wigley, co-owner of Margot, a popular restaurant in London’s Covent Garden recently forced to close.
Wigley, previously one of the City’s best-known investment bankers, posted on LinkedIn that one of the restaurant’s managers had told him: “We survived Covid but we can’t survive Labour.”
The government told CNBC that its tax changes were “tough but necessary,” and are needed to “protect working people’s payslips from higher taxes,” and invest in public services.
The British Retail Consortium, the main industry body, has estimated that the hike in employers’ NICs will cost the retail sector alone some £2.3 billion.
Other near-term factors include the recent rise in the minimum wage from £11.44 ($15.38) an hour to £12.21. The age at which it kicks in was also reduced from 23 to 21 — making it more expensive to hire younger workers — while the rate for 18-20-year-olds rose from £9.60 an hour to £10. Wages have also been rising more broadly, following several years of above-average earnings growth across the economy, a result of the U.K.’s tight labor market and the rise in economic inactivity since the pandemic.
But as unemployment — and with it, job insecurity — starts to rise, consumers are increasingly eating into their savings or becoming more frugal. The U.K.’s savings ratio, which spiked during the pandemic and remained high afterwards, is now falling for the first time this decade.
Closing down sale red poster on Oxford Street on 23rd March 2025 in London, United Kingdom.
Mike Kemp | In Pictures | Getty Images
As Clive Black, head of consumer research at the investment bank Shore Capital and one of the City’s most renowned retail-watchers, put it in a recent client note: “U.K. consumers are low on confidence, fed up with broken Britain.”
Local councils have also pushed up parking charges and introduced so-called “low traffic neighborhoods,” making high-street shopping tricky for those who rely on their cars, prompting many bigger operators —the likes of Next and Marks & Spencer — to shift to out-of-town retail parks.
But there are also longer-term factors. Business rates — a tax dating back 400 years levied on the “rateable value” of most non-domestic properties such as shops, offices, pubs and warehouses — hit bricks-and-mortar retailers much harder than online retailers like Amazon, which is also blamed for sucking business away from the high street.
In its election manifesto last year, the governing Labour Party promised to “level the playing field between the high street and online giants,” but its solution — hitting larger properties more heavily to fund lower rates for smaller premises — has alarmed many in the sector, including supermarket multiples like Tesco, Sainsbury’s and the Co-op. The government says its business rates system is designed to “protect the high street” and support investment.
Regardless, the acceleration in store closures has raised fears that this is a structural downturn, rather than just cyclical. There is some evidence for this.
In the past, when an established retailer was forced out of business, other operators stepped in to take its place. A good example is the U.K. arm of Woolworths, the much-loved variety store chain, whose 807 outlets closed — with the loss of 27,000 jobs — in late 2008 and early 2009 at the height of the financial crisis. New tenants were quickly found for many of these as rivals, such as B&M, stepped in to take the sites at a cheaper rent. Many of these, including the likes of Poundland, Poundstretcher and Original Factory Shop are now themselves struggling.
However, more recently when a store has closed, it has remained closed, which, added to the exodus to retail parks, has left many high streets with a sense of decay. When a big retail destination closes or moves out, footfall is reduced.
Accordingly, a typical British high street, which in the 1980s or 1990s boasted familiar names like Boots, Woolworths and Marks & Spencer, is more likely these days to be home to vape shops, American-style candy stores, tattoo parlors and charity shops (the latter of which benefit from significantly lower business rates).
The sense that this is a structural change also reflects a shift in retail property ownership. The big U.K. commercial property players such as Land Securities and British Land, where they have exposure to the retail sector at all, will do so largely via retail parks or shopping centers. The typical high street landlord is more likely these days to be a “mom and pop” operator unable to offer tenants better terms when they run into difficulty.
All of this sounds like a perfect storm, yet there is another, less frequently acknowledged factor at play: going into the 21st century, when Amazon began eating the lunch of the old bricks-and-mortar retailers, there were simply too many players.
Many retailers will not countenance the idea, but perhaps what we have seen over the last quarter century is simply over-capacity being taken out of the market.
— Ian King
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Need to know
In the markets
U.K. stocks have been strong outperformers over the past week, with the FTSE 100 gaining 1.6%. The index notched a record intraday high above 9,000 points on Tuesday.
London-listed companies have been boosted by the fact that the U.K. has already negotiated a trade deal with the White House, while business in the European Union remain mired in uncertainty — and under threat of 30% U.S. duties — heading into earnings season.
Further support has come from a decline in sterling, which has dropped 1.5% against the U.S. dollar to $1.339 over the past week, as Bank of England Governor Andrew Bailey suggested the central bank would be more forceful with interest rate cuts if the labor market weakens. A weaker pound can be beneficial to FTSE 100 firms, a majority of which derive their revenue overseas.
The gilt market has been relatively calm following its recent spell of volatility. The 10-year yield has eased to 4.62% from 4.63% over the past seven days, while the 2-year yield is down to 3.83% from 3.88%.
The performance of the Financial Times Stock Exchange 100 Index over the past year.
The Harris hawks have been wowing the crowd at The Open, their handler says
Golf fans flocking to Northern Ireland’s north coast to watch The Open will be hoping to see more than a fair share of birdies and eagles.
But it is a team of birdies of the feathered variety that are working hard to protect the golfing public over the coming days.
A cast of Harris hawks has been drafted in by tournament organisers to keep hungry seagulls away from the course.
Falconer David Trenier told BBC News NI the hawks are making sure golf fans can enjoy their food in peace.
“They are very, very sociable, used to working with large crowds and are big enough to spook the gulls enough to move them off,” he said.
Four hawks have been on the course “morning and night” since the gates opened to the public on Sunday, Mr Trenier said.
The birds – named Aurora, Belle, Caine and Cheyenne – will rotate in shifts throughout the tournament.
The team from Clear Skies Falconry Pest Control is specifically tasked with patrolling the skies over areas where food is served.
Clear Skies Falconry
Hawks Cheyenne (left) and Caine (right) and their handlers are part of a team that patrol the skies over the Portrush golf course
Situated on the north Antrim coast, Portrush is a familiar haunt for seagulls.
Often, Mr Trenier said, the gulls can have “an aggressive nature for food”.
“When they come in, the presence of the hawk on the course puts them off, they make sure the gulls don’t come down” he said.
They are the ideal bird for the job, Mr Trenier added, and a “clean and green method of pest control”.
It is a method used frequently at other major sporting events.
Previous Open Championships at Troon and St Andrews have similarly called on birds of prey, while Rufus, an American Harris hawk, has been scaring pigeons at Wimbledon for more than 15 years.
PA Media
Rufus first patrolled Wimbledon in 2008, when he was only 16 weeks old
The tournament-going public seem to love them, Mr Trenier said.
“It is so lovely to see the public reaction, they want to talk and they want to ask questions.
“The kids want to have a picture taken and know more about them.”
The Harris hawks will be joined over the weekend by Pilgrim – Clear Skies Falconry’s 24-year-old bald eagle.
“He will definitely disturb the gulls,” Mr Trenier said.
He added that Pilgrim’s presence also tips a cap to the large contingent of American golfers playing at Portrush because the species is the national bird of the United States.
More than 275,000 spectators are expected during the eight days of practice and competition, making it the largest sporting event held in Northern Ireland.