- PM reaffirms Pakistan’s commitment to serving humanity RADIO PAKISTAN
- Dar urges global solidarity to address rising humanitarian crises Associated Press of Pakistan
- Humanity transcends all boundaries, relationships: CM Maryam Dunya News
- PM reiterates Pakistan’s commitment to serving humanity on World Humanitarian Day Dunya News
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PM reaffirms Pakistan's commitment to serving humanity – RADIO PAKISTAN
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Normal abnormal – Newspaper – DAWN.COM
THE humidity hangs heavily in the air but doesn’t deter the quiet protest by a small group of women. They sit silently, their heads bowed, a small splash of colour against the grey concrete. With their old-fashioned hand fans, they occupy a sheet of plastic in the middle of the road.
The nearby green areas, which once allowed Pakistan to bring its problems to Islamabad by holding protests there, is closed to these women. The earth and grass are far too comfortable for them to be allowed there. They have to sit on the road, close to a busy commercial area, but away from the business in the area, as traffic barriers create a boundary, separating them from life in the capital. They have been here for a month but have not managed to disturb the life of the city or the government. How can they when even the doors of the washrooms of the press club close by are closed to them? Those who should be the flag-bearers of freedom of information are now a part of a system which bears down on citizens rather than standing up for the oppressed.
So it’s not just the washrooms but also coverage which is denied. These protesters are ignored, blacked out. There was a time, when such a gathering would have galvanised enough opinion to put any government on the back foot. Not anymore. The women’s steadfastness in this heat and in these circumstances moves no one. Perhaps partly because most people do not even know they are here and partly because this government has no space to even pretend to care about human rights.
The protest has been rendered invisible.
But then the political suffering of women has been normalised in the abnormal times we live in — the women in Islamabad who are not even allowed to sit on grass lest it prove too comfortable, or Mahrang Baloch who has been imprisoned with little chance of any relief in the near future. In Lahore, Yasmin Rashid has been behind bars for two years, with little concern for anyone outside of her party (which can barely do more than pay lip service to the matter). Her age moves no one; neither do the elderly women sitting on the road in this heat in a corner of Islamabad, carrying pictures of their missing loved ones in their heavily wrinkled hands. Their endless wait is for closure as well as some compassion from those in charge.
Ask the government about anything untoward and they simply shrug it off.
But suffering and lack of compassion have been normalised in the abnormal times we live in. As has been the indifference of political parties, which can no longer even pretend to care. Not even those who continue to bask in the glory of a woman who was once the lone symbol of suffering and the target of the powerful ones.
This is not all that has been normalised.
Consider journalism. Arrests, FIRs, disappearances — temporary and permanent — were part of what journalists signed up for. What it meant was that only the brave ones would continue down certain paths (most opened the door and walked through to the compound where awards adorn one’s resumé). But despite this, we have seen a fair share of brave souls who continued to face the dangers. Here too, though, there is an effort to remind them that this may not prove enough.
In recent times, at least two journalists have spoken about how the bank accounts of family and even acquaintances have been blocked. Parents, siblings and even vendors who made the mistake of selling to pesky journalists have been affected. The only recourse left to them were the courts, which, too, are now enveloping themselves in the mantle of indifference. But the message is that collective punishment is the fate of those who will not heed more specific messages about falling in line. Or that the element of surprise will always be their fate. When blocked bank accounts did not prove enough, one of them was stopped from flying out of the country recently. Since then, a PTI politician’s daughter has also found her way to the list. Her father is neither in power nor in parliament and is perhaps not in a position to make any decision but still had to be sent a message. And for this, a university student was stopped from leaving the country, putting her education at risk.
In all of these random, seemingly disconnected incidents, there is a commonality — no one can be asked about them or even shamed. The government has moved beyond this — ask them about anything untoward and they simply shrug it off. There must be a reason, a valid reason, is the only answer. If it’s a journalist, he or she must have done something wrong to attract the ‘long arm of the law’. And if there is a story involving a politician from the opposition, the easiest response is to either hint at the former’s non-patriotic credentials or feign ignorance and move on.
Indifference has been normalised in these abnormal times.
And while some of us do express horror, grief and shock, it amounts to little; the second such incident is taken in its stride. It has already happened to others and if the previous incident was accepted, so should the new one. The shock and horror turns into acceptance.
But then, these are abnormal times, we tell ourselves. And they might not last and neither will these stories. However, this provides little comfort for I can remember when we first began to hear of ‘missing people’; when stories about the missing were read avidly because it was so new. Or when suicide bombings first happened in Pakistan. Then the times changed, leaders changed but we learnt to live with the missing and the suicide bombers. Times don’t last necessarily but the abnormal soon becomes normal.
The writer is a journalist.
Published in Dawn, August 19th, 2025
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On a wing and a prayer – Pakistan
WHEN most European countries and Volodymyr Zelensky were praying together with American neocons for the collapse of Vladimir Putin’s Alaska summit with Donald Trump, India was vocal in hoping for its success. The Indian idea was laudable, only the argument was a tad self-regarding. If the talks ended on a positive note, assorted Indian analysts reasoned, the impugned oil trade with Russia would no longer draw Trump’s ire. Putin would have saved the day for New Delhi.
On a wing and a prayer, the Modi foreign policy has bodily lifted its model from international sports contests where the ousted team pulls out its pocket calculators to desperately speculate its chance of returning to the contest should some other team beat another team. China is also affected by Trump’s frowning on its Russian oil imports. But the Communist Party-backed Global Times headline seemed in no tearing hurry to eye Beijing-centred success or failure in the otherwise important US-Russia talks. All the paper said was: “Trump and Putin addressed a joint press conference.”
And that is more or less what we know did happen. Much else is speculative. It is evident, Prime Minister Modi’s foreign policy prefers to ride piggyback on future outcomes over which it exerts no control. This is not how it used to be. A vital difference has emerged between then and now.
Indira Gandhi took Soviet help to bridge military and economic gaps. Yet she censured Moscow when the ally invaded Afghanistan. Nehru had the best of relations with Britain and even made India a member of the Commonwealth for which he was criticised roundly by his leftist supporters. Majrooh Sultanpuri found himself writing some memorable songs for the blockbuster movie Andaz from prison where he was sent for penning an acerbic poem against Nehru’s Commonwealth membership. But even as a member of the Commonwealth Nehru stoked the anti-colonial fervour in Asia and Africa, which won him lifelong friendships in the Global South.
Why is it so difficult to instil a simple, inexpensive idea for diplomacy?
Nehru supported the rise of China as a major post-colonial power but was misled by a combination of historians and cartographers into laying claim on tracts of Tibet that China had refused to accept during British rule. Nehru paid the price for his decision, until his grandson travelled to shake hands with Deng Xiaoping in a memorable move in 1988. Even Atal Bihari Vajpayee decided for better or worse to accept the heavy cost of declaring India a nuclear power even though he slipped up by explaining to Bill Clinton that the bomb was aimed at China. Everyone did what they deemed good for the country, which can’t be said of Narendra Modi. He has been doing whatever he could to appease the US until Trump poured cold water on the enthusiasm.
And yes, Indira Gandhi waged a decisive war on Pakistan but bore no ill will towards its people. She had a landmark meeting with Z.A. Bhutto in Shimla. Likewise, Rajiv Gandhi and Benazir Bhutto had a widely cheered rendezvous in Pakistan. Vajpayee and Manmohan Singh came close to resolving the Kashmir issue and, importantly, they did so with the help and support of their people, not of a foreign prompter. That’s what is missing in the pocket calculator diplomacy today, the engagement of the people on both sides of the equation, be it with Pakistan, or Bangladesh or Sri Lanka. India’s military has a problem with Pakistan’s military. But it’s Pakistan’s people that are known to have shown the door to many dictators, military or civilian. Modi has sidelined people on both sides. Faiz Ahmed Faiz’s daughters were denied visas for the first time in India’s history. Now, Modi has announced an iron dome-like project to protect the country from enemy attacks. Many see it as a wasteful idea given the hammering a heavily guarded Israel took from Iran recently.
Why is it so difficult to instil a simple, inexpensive idea for diplomacy? Why not let the masses — as opposed to state-backed mobs — take the initiative to build inevitable excellent ties, and see the menace called terrorism vanish in a jiffy?
Many current foreign policy preferences are, of course, rooted in Modi’s ideological pursuit of Hindutva. Or more accurately, it’s about marrying big business with Hindutva and passing it off as national interest. Of course, other than pervasive corruption, this has led to little else, as can be gleaned from the criminal cases in the US involving a major tycoon.
Bureaucracies, too, play a role in the wrack and ruin of India’s fair name. Inured to the social costs that state policies incur, they formulate or conjure ‘national interest’ from personal expediencies or biases, which currently seem to be heavily tilted towards the West. Much has been said about Modi’s Mittyesque media, which cut a sorry figure in the recent military engagement with Pakistan. But what does one make of respected current and former diplomats? One such served in Islamabad as high commissioner. In his view, in the absence of a decisive military victory, India should periodically “mow the grass” in Pakistan, a phrase used by Israel for periodically raiding Gaza and killing Palestinians before the events of October 2023. Mow the grass in nuclear Pakistan?
India has experienced many economic woes, mostly caused by oil price fluctuations. When the prices went through the roof in 1990, and the USSR had all but disappeared, the country pawned gold reserves to stave off defaulting. People accepted it. V.P. Singh was prime minister when the oil crisis began. He announced rationing on petrol. People understood. There were regulations about using cars. People took it in their stride. Something has changed today. It’s more about guarding the interests of this or that business house refining Russian oil to ship it off to Europe. From the dominant Indian perspective, the Alaska summit was about Russian oil, sadly, not about saving the world from nuclear annihilation.
The writer is Dawn’s correspondent in Delhi.
jawednaqvi@gmail.com
Published in Dawn, August 19th, 2025
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Targeting a sugar metabolism pathway offers hope for treating rare and aggressive childhood cancer
A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that might be exploited to improved treatments for patients.
MPNST is a rare and deadly childhood cancer, which mainly affects teenagers and young adults. These tumors grow quickly, spread easily, and don’t respond well to current treatments. Metastasis is the leading cause of death in MPNST and there currently are no targeted treatments for metastatic disease.
The study, led by University of Iowa researchers Eric Taylor, PhD, professor of molecular physiology and biophysics, and Rebecca Dodd, PhD, associate professor of internal medicine, identifies a specific metabolic pathway that is critical for MPNST cells’ survival and growth, which could potentially be targeted with future therapies.
Targeting cancer metabolism to slow tumor progression
To better understand these tumors, the UI researchers used gene editing to create new research models that closely match the cancer-driving mutations found in patients. Using these models, they then applied state-of-the-art genomic and metabolomic tools to map the metabolic pathways that fuel tumor growth in MPNST.
The study, published in Science Advances, found that these cancers rely on a key metabolic pathway to help them survive oxidative stress and drive tumor growth. This pathway, known as the Pentose Phosphate Pathway (PPP), metabolizes sugar to produce a critical antioxidant molecule that the cancer cells require to combat oxidative stress. When the researchers blocked the PPP, the tumors grew more slowly and were more vulnerable to chemotherapy.
This is the first time this specific metabolic pathway has been linked to MPNST tumor growth, making it a completely new target for therapy in this cancer type. It opens the door to treatment strategies that haven’t been explored before and could lead to more effective treatments and better outcomes for patients who urgently need new options.”
Rebecca Dodd, PhD, associate professor of internal medicine, University of Iowa
The highly collaborative study combined Dodd’s expertise in cancer biology with Taylor’s expertise in metabolism. The lead author was UI graduate student Gavin McGivney, PhD, from Bayard in Guthrie County, Iowa, who was co-mentored by Dodd and Taylor. McGivney graduated from the UI Cancer Biology graduate program in 2024, and is now a postdoctoral scholar at University of Chicago. Dodd and Taylor are both members of UI Health Care Holden Comprehensive Cancer Center, and Taylor is a member of the UI Fraternal Order of Eagles Diabetes Research Center.
In addition to Dodd, Taylor, and McGivney, the research team also included UI researchers in the Departments of Internal Medicine, Molecular Physiology and Biophysics, and Radiation Oncology at the UI Roy J. and Lucille A. Carver College of Medicine. Researchers at Washington University School of Medicine, University of Texas MD Anderson Cancer Center, and the University of Toronto, were also part of the team.
The research was funded in part by grants from the Children’s Tumor Foundation, the National Institutes of Health, the American Heart Association, the U.S. Department of Defense, and the American Cancer Society through Holden Comprehensive Cancer Center.
Source:
University of Iowa Health Care
Journal reference:
McGivney, G. R., et al. (2025). Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Science Advances. doi.org/10.1126/sciadv.adu2906.
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Worst civilian era? – Newspaper
NONE of our past regimes established durable progress and many have even put us back. But perhaps only Zia’s era, our worst one by far, matches the reversals we have seen under the current hybrid set-up in just 18 months, contrary to claims of making major progress.
The main harm has been done to democracy as civilian sway is at its lowest in key areas. While our two oldest parties are ruling overtly, they seemed to have nixed the political progress of yore. They began by violating their Charter of Democracy oath not to win power with the establishment’s aid. In 2013, they had ensured our only fair civilian power transfer but won this time through arguably our most rigged poll since the 2002 one held under martial law. To end rigging by incumbents, both had adopted the global good model of neutral caretakers that bars them from joining the next set-up to reduce conflict of interest. But in 2024, they bent their own good law to induct caretakers in cabinets.
Our post-2009 higher judiciary hiring system too was among the best globally as its use of judicial and balanced bipartisan assembly committees ended the executive’s hold. But instead of improving it by adding merit criteria and open applications, they re-cemented the executive hold, which has harmed the judiciary. A crackdown is underway against the PTI, nationalist Baloch and KP groups and even ordinary citizens reminiscent of the Zia era. Media and other freedoms are being nixed via bad laws. While they had rightly criticised the PTI’s era for such political sins, their own have now left the former behind.
The government has achieved fragile economic stability but is clueless about durable growth. The real economic reversal, though, is the loss of ambition. CPEC, along with the Gulf inflows, was a solid way of industrialising. But 10 years later, greater attention is focused on US ties in controversial areas like crypto and natural wealth — a globally feared curse for misruled states like ours — plus remittances and establishment-led farming. The last seems to reflect a concern that greater industrialisation may bring in meritorious rulers, and so dubious sectors are a better focus for the rulers’ narrow interests. Zia had done the same. Ayub and Bhutto had at least adopted varied, though faulty, state-led ways to industrialise. But Zia moved the focus to predatory sectors such as US aid, real estate, etc.
The main harm has been done to democracy.
Insecurity is increasing and negatively affecting the gains of the 2008-18 era. While this set-up rightly pins the blame for this trend on the PTI-era hybrid government for resettling TTP fighters in KP, its own steps have exacerbated matters. Its forcible approach to Balochistan, even towards peaceful marchers, is pushing common people away from normal politics. Oddly, we tell other states facing terrorism to address the root causes but avoid doing so ourselves in Balochistan. Many say the state’s distinction among ‘good and bad’ Taliban stokes terrorism in KP and new operations will only add to people’s miseries.
The big reversal externally is the rekindling of that old, on-off romance with the US via personal, non-civilian ties instead of normal state ties. While the regime calls it progress, many vividly recall the damage three decades of such ties did. The chances of us being fourth time lucky are slim as the key actors on both sides resemble past ones. For us, it’s again a set-up desperately seeking global patrons to overcome its low domestic legitimacy and su-rvive. For the US, it’s a very short-visioned and self-centred (Trump) regime even by US norms. So, many fear the results may benefit our ruling elites but harm the masses.
So, all the reversals approach those in non-civilian eras, making one wonder if this will be the worst civilian era ever and how much more harm it will cause. Sages say talks are the best way out of the mess. But strong autocracies don’t voluntarily concede; instead, they use talks to pressure dissidents to yield and give themselves legitimacy. The current set-up might only accept calls for fair polls, civilian sway, judicial freedom and end to crackdowns if dissidents form a strong joint platform, which seems unlikely for now.
Though the nation is angry, it remains divided. Diverse angry groups are angry on diverse issues and often don’t relate to and even oppose the basis of anger of other angry groups. So, regime may cave in under the weight of its own missteps, as always pushed gently and jointly by dissidents.
The writer has a PhD from the University of California, Berkeley, in political economy and 25 years of grassroots to senior-level experiences across 50 countries.
murtazaniaz@yahoo.com
X: @NiazMurtaza2
Published in Dawn, August 19th, 2025
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Chikungunya fever cases continue to drop in south China
A staff member sprays insecticide at Zhuangtou Village in Shunde, Foshan City, south China’s Guangdong province, July 25, 2025. [Photo/Xinhua]
The number of local cases of Chikungunya fever has dropped from a daily peak of over 600 to less than 100 in Foshan, south China’s Guangdong province, indicating further progress delivered by effective prevention and control measures during the early stage, according to experts with a national disease control and prevention team dispatched to the city.
Statistics from Foshan’s public health authority showed that 84 new confirmed cases of Chikungunya fever were reported on Aug. 14 in the city, which has been hit the hardest by the mosquito-borne viral disease since its recent outbreak in China. Starting from Aug. 9, the city’s tally of newly confirmed cases has continued to decline at a steady pace.
At present, new cases in Foshan are sporadic, said Ren Dongsheng, a researcher with the Chinese Center for Disease Control and Prevention (China CDC), adding that in the next step, prevention and control measures will be taken in a more precise and targeted manner to further stem the transmission of the disease.
Chen Zhihai, director of the infectious disease center of Beijing Ditan Hospital affiliated with Capital Medical University, noted that while fever, rash and joint pain constitute major symptoms of this disease, there has been no report of after-effects among all Chikungunya fever patients in Foshan.
The experts noted that the environmental conditions in Guangdong are relatively suitable for the survival of mosquitoes, and adult mosquitoes can survive for one to two months or even longer.
Therefore, the extermination of adult mosquitoes is a key measure in the prevention and control of Chikungunya fever.
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Landmark robotic spine surgery advances pediatric orthopedic care at Ochsner Children’s
Ochsner Children’s has achieved a major milestone by performing the first robotic-assisted pediatric spine deformity surgery in Louisiana and the Gulf South. This recently completed procedure represents a significant step forward in patient safety and precision reaffirming Ochsner Children’s leadership in innovative pediatric orthopedic care.
The procedure was performed by Ochsner Children’s pediatric orthopedic surgeons, Ryan Farmer, MD and Lawrence Haber, MD, on a patient diagnosed with Scheuermann’s kyphosis, a spinal condition characterized by a severe forward leaning curvature in the spine. The surgery utilized Globus Medical’s revolutionary ExcelsiusGPS® robotic system, a state-of-the-art platform technology that enhances the surgeon’s ability to plan and execute precise implant placements, significantly improving the safety and accuracy of spinal procedures.
Robotic-assisted surgery is on the cutting-edge of pediatric spine surgery and is a big win for all our kids with spinal conditions. With advanced imaging and computer guidance, we can place implants with greater accuracy-making surgery safer for our patients.”
Dr. Ryan Farmer, MD, Ochsner Children’s pediatric orthopedic surgeon
Robotic-assisted spine surgery advantages extend beyond precision. By incorporating this technology, Ochsner Children’s empowers its surgical teams with the ability to meticulously plan procedures in advance, determining the size, trajectory, and placement of each implant while enhancing control.
“This is an important step forward for families in Louisiana and the Gulf South,” said Dr. Haber, who also serves as Ochsner Children’s section head of pediatric orthopedics. “Our goal is always to make surgery safer, more precise, and to improve outcomes for kids. This new procedure is a big moment for pediatric care-and a sign of what’s possible when we explore innovative solutions to treat children with complex conditions.”
The integration of robotic technology into pediatric orthopedics marks the continuation of Ochsner’s legacy of pioneering advancements in patient care. By adopting cutting-edge solutions, Ochsner Children’s is shaping the future of pediatric healthcare and reaffirming its role as a trusted partner for families seeking expert medical treatment.
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Treaty impasse – Newspaper – DAWN.COM
RECENT efforts in Geneva by some 183 countries on a global plastics treaty ended in stalemate. There were deep divisions between nations pushing for production caps and those prioritising recycling and waste management. Now, without any consensus, the world remains without a binding agreement to curb the worsening crisis of plastic pollution, which has left not only our oceans and soil contaminated, but also our bloodstreams. Pakistan’s delegation at the conference took a strong line, highlighting equity and justice concerns. Climate Minister Musadik Malik highlighted how it is developing nations that suffer disproportionately from plastic pollution while wealthier states — often the largest producers and consumers — benefit most from green financing. Pakistan pressed for fair access to funds, technology transfer and capacity-building, and even floated the idea of a plastic credits market to support recycling and the livelihoods of waste workers. Furthermore, by seeking to build alliances across the Global South, Islamabad pointed out that poorer countries cannot shoulder the burden of transition without adequate support.
However, Pakistan’s advocacy on the global stage must be matched by discipline at home. While all the provinces have issued decrees banning single-use plastic bags, the flimsy carriers still change hands in bazaars from Karachi to Peshawar. Our understanding of and emphasis on recycling is rudimentary, waste is rarely segregated and collection has become the burden of poorly paid, unprotected waste pickers. The state must prove it means business: enforce provincial bans, punish violators and back the spread of biodegradable packaging. Changing entrenched consumer habits needs sustained awareness drives, while investment in proper garbage collection and waste segregation is essential to stem the tide of plastic litter. Policymakers must encourage innovation in packaging, nurture a viable recycling industry and bring the informal army of waste pickers into the formal economy with protections and pay. Calls for fairness abroad will carry more weight if they are backed by action at home.
Published in Dawn, August 19th, 2025
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Market exchange rates in China — Aug. 19-Xinhua
BEIJING, Aug. 19 (Xinhua) — The following are the central parity rates of the Chinese currency renminbi, or the yuan, against 25 major currencies announced on Tuesday by the China Foreign Exchange Trade System:
Currency Unit Central parity rate in yuan
U.S. dollar 100 713.59
Euro 100 834.27
Japanese yen 100 4.8391
Hong Kong dollar 100 91.247
British pound 100 966.20
Australian dollar 100 464.62
New Zealand dollar 100 424.26
Singapore dollar 100 556.92
Swiss franc 100 885.61
Canadian dollar 100 518.35
Pataca 112.94 100
Malaysian ringgit 59.042 100
Ruble 1,119.50 100
Rand 246.58 100
Korean won 19,379 100
UAE dirham 51.322 100
Saudi riyal 52.433 100
Hungarian forint 4,732.69 100
Polish zloty 50.922 100
Danish krone 89.47 100
Swedish krona 133.60 100
Norwegian krone 142.49 100
Turkish lira 571.028 100
Mexican peso 262.73 100
Thai baht 453.51 100
The central parity rate of the yuan against the U.S. dollar is based on a weighted average of prices offered by market makers before the opening of the interbank market each business day.
The central parity rate of the yuan against the Hong Kong dollar is based on the central parity rate of the yuan against the U.S. dollar and the exchange rate of the Hong Kong dollar against the U.S. dollar at 9 a.m. in international foreign exchange markets on the same business day.
The central parity rate of the yuan against the Pataca is based on the central parity rate of the yuan against the Hong Kong dollar and the exchange rate of the Pataca against the Hong Kong dollar at 9 a.m. in international foreign exchange markets on the same business day.
The central parity rates of the yuan against the other 22 currencies are based on the average prices offered by market makers before the opening of the interbank foreign exchange market. ■
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Rain likely in various parts of country: PMD – RADIO PAKISTAN
- Rain likely in various parts of country: PMD RADIO PAKISTAN
- Sindh govt says arrangements in place as parts of Karachi receive light rain Dawn
- Fresh deluge feared as NDMA issues urgent warning The Express Tribune
- NDMA advises public to avoid travel in mountainous areas amid heavy rains, landslides Business Recorder
- Emergency control rooms established at all tourist, historical sites nation.com.pk
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