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  • Lung cells generated from mouse embryonic fibroblasts in just 7 to 10 days

    Lung cells generated from mouse embryonic fibroblasts in just 7 to 10 days

    Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse embryonic fibroblasts without using stem cell technology. The AT2-like cells were generated in just 7 to 10 days-a significant reduction compared to the approximately one month typically required by conventional stem cell-based differentiation methods.

    This approach may pave the way for treating serious respiratory diseases, such as interstitial pneumonia and chronic obstructive pulmonary disease, which currently lack effective treatments. The study was published in npj Regenerative Medicine.

    AT2 cells are essential for maintaining lung homeostasis. They produce surfactant and serve as progenitor cells for alveolar repair. In patients with severe lung diseases, such as interstitial pneumonia, these cells are often reduced in number or functionally impaired, which highlights the therapeutic potential of regenerating AT2 cells.

    The advent of the induced pluripotent stem cell (iPSC) technology in 2006 has enabled the generation of AT2 cells in approximately one month, but this method is costly and carries risks of tumor formation and immune rejection. To overcome these disadvantages, we focused on direct reprogramming instead. The direct reprogramming approach produces AT2-like cells in just 7 to 10 days, with lower tumor risk and potential for autologous use.”


    Professor Makoto Ishii of Nagoya University Graduate School of Medicine

    Professor Ishii and colleagues, including Professor Koichi Fukunaga, Assistant Professor Takanori Asakura, and Joint Researcher Atsuho Morita from Keio University School of Medicine, conducted a study to generate AT2-like cells from fibroblasts in mice through direct reprogramming, which had never been accomplished before.

    First, the researchers selected 14 candidate genes associated with lung development. Then, they investigated the expression levels of the AT2 cell marker, surfactant protein-C (Sftpc), to determine the gene combination with the highest reprogramming efficiency. They found that a combination of four genes-Nkx2-1, Foxa1, Foxa2, and Gata6-was the most effective for reprogramming AT2 cells.

    The four genes were introduced into a three-dimensional culture made from mouse embryonic fibroblasts that express green fluorescent protein (GFP) in response to Sftpc. As a result, approximately 4% of the cells became Sftpc/GFP-positive in 7 to 10 days, showing their success in inducing AT2-like cells, called induced pulmonary epithelial-like cells (iPULs).

    The researchers analyzed iPULs after isolating GFP-positive cells by flow cytometry. These purified iPULs exhibited lamellar body-like structures, which are organelles characteristic of normal AT2 cells. In addition, transcriptomic analysis revealed that their gene expression profiles were highly similar to those of native AT2 cells.

    Next, they transplanted purified iPULs into mouse lungs with interstitial pneumonia. Forty-two days later, the transplanted cells had successfully engrafted in the alveolar region. Notably, some of the cells had differentiated into alveolar epithelial type 1 (AT1)-like cells, which are essential for lung tissue regeneration.

    Ishii concluded: “In this study, we succeeded in direct reprogramming of fibroblasts into AT2-like cells in mice. We now aim to explore the application of this technology to human cells, with the ultimate goal of developing a safe regenerative therapy using a patient’s own fibroblasts.”

    This study was funded by JSPS KAKENHI Grant Numbers JP24K02113, JP24K23468, JP22KJ2672, JP21J21344, JP21H02926, JP19K17682, JP18K19566, JP18H02821, JP15K19945, and AMED Grant Numbers JP21bm0404053, JP23wm0325031, and JP24ym0126807.

    Source:

    Journal reference:

    Morita, A., et al. (2025). Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells. npj Regenerative Medicine. doi.org/10.1038/s41536-025-00411-4.

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  • Oscar Piastri not expecting Silverstone fight to just be with Lando Norris as he predicts ‘interesting weekend’

    Oscar Piastri not expecting Silverstone fight to just be with Lando Norris as he predicts ‘interesting weekend’

    Oscar Piastri has predicted a potential multi-team battle at the British Grand Prix, with the Australian suggesting that it will not just be a fight between himself and McLaren team mate Lando Norris.

    A race-long scrap played out between the pair last time out in Austria, in which Norris fended off the challenge from Piastri to claim his third win of the season. Piastri, however, still leads the championship standings by a margin of 15 points.

    When asked if he was ready for another battle with Norris this weekend at his team mate’s home track, Piastri smiled: “Let’s wait and see. I think it’s going to be an interesting weekend – Silverstone always is. The weather’s always a factor and it looks like it will be again this weekend.

    “Let’s wait and see, I don’t think it will just be two McLarens this time. I think Mercedes will probably be quick, Red Bull honestly you never really know but they’ve been quick here in the past, Ferrari as well looked to be a little bit stronger in Austria, so let’s see.

    “It’s a track I always enjoy, and I’m expecting it to be a good fight with whoever it is.”

    A sequence has emerged during the campaign so far in which, whenever Norris has won a race, Piastri has proven victorious at the following Grand Prix.

    In terms of whether that might be on his mind during the weekend ahead, the 24-year-old answered: “I have found the same pattern as you, but there’s nothing conscious about it. I think it’s just been coincidence.

    “I always go into every weekend, just trying to do the best that I can. I felt like maybe in China there was a bit of extra motivation but more because of how painful Melbourne was, more than anything else.

    “I just go into every weekend trying to do my best, go in with the best state of mind that I can and I think I’m always learning things about myself, about how I need the car as well, and [I’m] learning lessons all the time.”

    And given the psychological element at play in the championship fight, Piastri was also quizzed on how important it would be to beat Norris at the Briton’s home track.

    “I don’t really think so,” the seven-time race winner said. “Every driver wants to win their home race, but at the end of the day it’s only worth the same amount of points as everywhere else. Monaco is kind of a similar feeling but, yes, would I love to win this weekend? Of course.

    “So let’s see what happens. It’s a track I enjoy, a track I’ve had good success at in the past, so hopefully can be a good weekend.”

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  • E Ink is turning the laptop touchpad into an e-reader for AI apps

    E Ink is turning the laptop touchpad into an e-reader for AI apps

    E Ink has developed a new touchpad for laptops featuring the same electronic paper technology found in e-readers. It’s not the first company to look at the ever-growing size of laptop touchpads and see the potential of additional functionality, but instead of serving as a second smaller screen for the computer’s OS, E Ink is positioning its touchpad as a dedicated home for AI applications and assistants.

    A mockup image shared by the company features a laptop with a touchpad upgraded with a color E Ink screen similar to what’s in use by devices like the Amazon Kindle Colorsoft. Instead of it being an extension of a laptop’s main screen, E Ink envisions its new touchpad as being a separate place where AI-generated text summaries could appear under your hands while working on a document, or you could maintain a constant conversation with an AI chatbot without having to juggle desktop windows.

    E Ink’s display technology only consumes power when it’s being updated. That’s a big benefit given the higher demands of AI tools on a laptop’s battery life.

    Similar to Apple’s now discontinued Touch Bar, E Ink also says the touchpad display could provide quick access to frequently used shortcuts, display notifications or the weather, or provide temporary playback controls without having to sacrifice a laptop keyboard’s row of function keys. It would also help reduce battery anxiety, because unlike LCD or OLED panels, E Ink’s display technology only consumes power when it’s being updated. That’s a big benefit given the higher demands of AI tools on a laptop’s battery life.

    What’s not currently known are more in-depth technical specifications. Aside from the touchpad potentially using color e-paper displays, E Ink hasn’t revealed if it will adapt one of its current panels, or if it’s developed an entirely new one with increased resolutions. Today’s announcement specifically references compatibility with Intel-based AI PCs, but E Ink didn’t go into details about whether the touchpad display would be powered by a laptop’s primary OS, or if it would feature its own. The company also didn’t provide a timeline for when these touchpads might start showing up in laptops or which hardware makers may be interested.

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  • Amex Cardmembers can now pay for flight bookings and onboard purchases on Wizz Air – American Express

    1. Amex Cardmembers can now pay for flight bookings and onboard purchases on Wizz Air  American Express
    2. Wizz Air adds Amex acceptance for flights and in-flight payments  The Paypers
    3. Wizz Air Enhances Travel Experience With New American Express Payment Option For Flights And Extras  Travel And Tour World
    4. Wizz Air expands payment options to include American Express  Aviation.Direct

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  • Traffic plan unveiled, MA Jinnah road to be closed for security measures

    Traffic plan unveiled, MA Jinnah road to be closed for security measures

    Listen to article


    KARACHI:

    Almost 50,000 police personnel will be deployed for the security of Muharram processions in Sindh, said Senior Minister Sharjeel Inam Memon addressing a press conference on Thursday.

    The tense geopolitical situation of the region compounded by collaboration of anti-state elements with the hostile neighbour warrants heightened security for the mass gatherings of Muharram.

    Sharjeel assured that the Sindh government has made foolproof security arrangements for Muharram.

    Most important was the unity of Ummah to defeat the designs of enemies of the country to use Muharram days to fan sectarian hatred and violence.

    The senior minister stated that the Chief Minister Murad Ali Shah held meetings with scholars from various schools of thought to assure harmony and reviewed the security plan for gatherings and processions.

    Sharjeel told the media that 14,546 police personnel would be deployed for gatherings and 35,116 for Muharram processions, with over 14,000 additional personnel assigned to ensure the security of all events.

    He announced that a total of 49,662 police personnel will be deployed across Karachi, Hyderabad, Sukkur, Larkana, Mirpurkhas, and Shaheed Benazirabad from the 8th to 10th of Muharram to prevent any untoward incidents and maintain peace.

    He emphasised that while the Sindh government tolerates criticism, it will not allow anyone to dictate its policies. He added that the government had also proposed allocating a large designated area for protests to ensure that public life remains unaffected.

    Traffic plan for three days of Muharram

    The Traffic Police have announced a special traffic plan for 8th, 9th, and 10th of Muharram. Under the plan, MA Jinnah Road will remain closed from Guru Mandir to Tower on all three days due to security concerns. The main Muharram processions will begin from Nishtar Park and conclude at Hussainia Iranian Imambargah, passing through its designated routes. Vehicles bearing special stickers issued for the procession will be allowed to join.

    As per the announced plan for traffic, commuters from Nazimabad can travel through Lasbela Chowk via Nishtar Road and Garden. Those coming from Liaquatabad can turn right at Teen Hatti towards Lasbela Chowk or to left towards Central Jail and Martin Road.

    Motorists coming from Hassan Square and heading to the PP Chowrangi can use Kashmir Road under Jail Flyover, Society Light Signal, Sharah-e-Quaideen, and Nishtar Road via Teen Hatti and Lasbela Chowk.

    Commuters from Sharea Faisal towards Sharah-e-Quaideen and Noorani Kabab to Numaish can take a right turn at Society traffic light towards Kashmir Road. Those heading to Guru Mandir or MA Jinnah Road via Jail Gate or Jamshed Road can take Bahadur Yar Jang Road and pass through Soldier Bazaar. Similarly, those at Garden Zoo heading to MA Jinnah Road will be diverted via Anklesaria to either Gul Plaza or Coast Guard, near Holy Family Hospital.

    All heavy and commercial vehicles from Super Highway or Gulberg towards MA Jinnah Road will be diverted from Liaquatabad No10 to Nazimabad Chowrangi No2, and then proceed via Habib Bank Flyover, State Avenue Road, and Shershah to Mauripur. The same route will apply for return.

    Heavy traffic coming from National Highway will take Sharea Faisal or Rashid Minhas Road, Stadium Road, Sir Shah Suleman Road, Hassan Square, Liaquatabad No10, and Nazimabad Chowrangi No2 towards Mauripur, and will follow the same route back.

    The Traffic Police spokesperson clarified that no small or large vehicles will be allowed beyond Guru Mandir Chowk on the procession route. All such traffic will be diverted towards Bahadur Yar Jang Road and Soldier Bazaar. Vehicles with stickers will be allowed entry from Sharah-e-Quaideen via Society Light Signal.

    Participants arriving from Nazimabad may enter via Lasbela, Al-Bela, Garden Jamaat Khana, Soldier Bazaar No3 traffic light to Numaish. Those from Liaquatabad, Teen Hatti, Jehangir Road, Guru Mandir, Society signal, Gulistan-e-Johar, Gulshan-e-Iqbal, University Road, Old Sabzi Mandi, Kashmir Road can also through Numaish.

    Vehicles distributing niaz or tabarruk will only be allowed entry into the procession from Tower near Memon Masjid. No vehicle will be permitted to park along the procession route.d

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  • Putin tells Trump he won’t back down from goals in Ukraine, Kremlin says – World

    Putin tells Trump he won’t back down from goals in Ukraine, Kremlin says – World

    Russian President Vladimir Putin told United States President Donald Trump in a phone call on Thursday that Moscow wants a negotiated end to the Ukraine war, but will not step back from its original goals, a Kremlin aide said.

    In a wide-ranging conversation that also covered Iran and the Middle East, Trump “again raised the issue of an early end to military action” in Ukraine, the aide, Yuri Ushakov, told reporters.

    “Vladimir Putin, for his part, noted that we continue to seek a political and negotiated solution to the conflict,” Ushakov said.

    Putin briefed Trump on the implementation of agreements reached between Russia and Ukraine last month to exchange prisoners-of-war and dead soldiers, Ushakov said, and told him that Moscow was ready to continue negotiations with Kyiv.

    “Our president also said that Russia will achieve the goals it has set: that is, the elimination of the well-known root causes that led to the current state of affairs, to the current acute confrontation, and Russia will not back down from these goals,” he added.

    There was nothing in the Kremlin readout to suggest that Putin had made any shift in Moscow’s position during the conversation with Trump, who took office with a promise to end the war swiftly but has voiced frequent frustration with the lack of progress between the two sides.

    The phrase “root causes” is shorthand for the Kremlin’s argument that it was compelled to go to war in Ukraine to prevent the country from joining Nato and being used by the Western alliance as a launch pad to attack Russia.

    Ukraine and its European allies say that is a specious pretext for what they call an imperial-style war, but Trump in previous public comments has shown sympathy with Moscow’s refusal to accept Nato membership for Ukraine.

    Putin and Trump did not talk about the US decision to halt some shipments of critical weapons to Ukraine, Ushakov said.

    On Iran, he said, “The Russian side emphasised the importance of resolving all disputes, disagreements and conflict situations exclusively by political and diplomatic means.”

    Trump last month sent US stealth bombers to strike three Iranian nuclear sites, in a move condemned by Moscow as unprovoked and illegal.

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  • Cape Town’s water crisis reveals about ancient climate shifts and our future

    Cape Town’s water crisis reveals about ancient climate shifts and our future

    Think of Earth’s water cycle as a well-choreographed dance, and climate change has started remixing the music. Some places are now drenched with extreme rain and flooding, while others are drying up under record-breaking droughts.

    Between 2015 and 2020, Cape Town, South Africa, faced a severe drought so extreme that officials warned the city was nearly out of water, calling it “Day Zero.”

    Scientists have puzzled over whether these events are just natural hiccups or driven by human-made climate change. Models suggest warming plays a role, but models aren’t the whole story, so researchers are digging into Earth’s past to see what history might reveal.

    In a new study, published in Nature Communications, researchers analyzed ancient plant matter preserved in a column of sediment drilled off the coast of South Africa. By analyzing hydrogen isotopes inside the plants from the rainfall, they could trace what the climate was like long ago.

    New technology to monitor near-real-time drought conditions

    They focused on a time called the Mid-Pleistocene Transition, about 1.25 to 0.7 million years ago, when Earth’s ice ages and atmosphere changed dramatically.

    They found that shifts in global air circulation, especially the Hadley cell (which moves air between the equator and 30° latitude), caused swings between wet and dry periods in Southern Africa, similar to the extreme drought Cape Town faced during its “Day Zero” crisis.

    The study shows that Earth’s climate has dramatically shifted before, triggering drought patterns like those seen in Cape Town’s “Day Zero” crisis. These ancient changes mirror today’s extremes, pointing to global climate change as a key driver behind such events, both in the past and now.

    EES graduate Claire Rubbelke ’25 Ph.D. said, “One big question I’m left with is whether these short droughts—and the Day Zero drought was relatively short-lived—will become more prolonged and eventually a permanent feature of the regional climate. The fact that past droughts appear in the sediment record suggests they persisted for many years.”

    Drought might not be the driver behind the disruption of Maya society

    In her future postdoctoral work, Rubbelke aims to study rainfall patterns along Africa’s eastern coast to compare them with past changes in the southwest. She hopes to uncover how shifting precipitation influenced early human evolution, especially in regions like the Cradle of Humankind. By examining how changes in vegetation and water sources affected where hominin species lived and thrived, her research could shed light on the environmental pressures that shaped our ancient ancestors.

    Journal Reference:

    1. Rubbelke, C.B., Bhattacharya, T., Farnsworth, A., et al. Southern Hemisphere subtropical front impacts on Southern African hydroclimate across the Mid-Pleistocene Transition. Nat Commun 16, 3501 (2025). DOI: 10.1038/s41467-025-58792-5

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  • Pakistan: Negligence by several departments uncovered in Swat drowning incident – ANI News

    1. Pakistan: Negligence by several departments uncovered in Swat drowning incident  ANI News
    2. Premier gets differing views on what to do with KP govt  Dawn
    3. Construction along Swat River diverted water flow, leading tourists into danger: report  The Express Tribune
    4. PM briefed on Swat River tragedy by KP Governor, orders enhanced preventive measures  Ptv.com.pk
    5. PHC demands accountability over Swat tragedy, seeks reports on rescue operations  Pakistan Today

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  • Pakistan Champions reveal jersey for WCL 2025

    Pakistan Champions reveal jersey for WCL 2025



    Pakistan Champions’ Shoaib Malik (centre) celebrates taking a wicket with teammates during their World Championship of Legends semi-final against the West Indies at The County Ground in Northampton on July 12, 2024. — Instagram/wclpakistanchampions

    Runners-up of the first World Championship of Legends (WCL), Pakistan Champions, unveiled their jersey for the second season of the event, scheduled to be held in Birmingham later this month.

    The star-studded franchise revealed its new emblem on the social media platform X, accompanied by the caption: “Proud to unveil the official jersey of the Pakistan Champions for the World Championship of Legends 2025.”

    Following a first successful season last year, the WCL T20 League is ready to come back for its second one in the July–August window.

    From six countries — India, Australia, Pakistan, South Africa, England, and the West Indies—the tournament includes cricketing legends.

    In the first season, Pakistan Champions ran an amazing campaign with overwhelming victories in the group stage.

    Their trip started with a victory against Australia, after which they crushed the West Indies. They posted 243/4 in a memorable high-scoring battle against their arch rivals India before limiting the Men in Blue to 175/9.

    Led by former Pakistan skipper Younis Khan, the squad kept up their remarkable form with a victory against England; their only groupstage loss came against South Africa.

    Securing a 20-run win to book a place in the final against India, the Men in Green progressed to the semifinals where they overcame the West Indies once again.

    Pakistan set a target of 157 in a tight final, but India pursued it down in 19.1 overs to take the championship with a five-wicket victory.

    For the unversed, on July 18, Pakistan Champions will play England Champions at the famous Edgbaston Stadium in Birmingham to start the second season of the WCL.

    Scheduled for July 20 at the same location is the much awaited conflict between archrivals India and Pakistan.

    Complete Tournament Schedule

    League Stage

    July 18 (Friday): England Champions vs Pakistan Champions

    July 19 (Saturday): West Indies Champions vs South Africa Champions

    July 19 (Saturday): England Champions vs Australia Champions

    July 20 (Sunday): India Champions vs Pakistan Champions

    July 22 (Tuesday): England Champions vs West Indies Champions

    July 22 (Tuesday): India Champions vs South Africa Champions

    July 23 (Wednesday): Australia Champions vs West Indies Champions

    July 24 (Thursday): South Africa Champions vs England Champions

    July 25 (Friday): Pakistan Champions vs South Africa Champions

    July 26 (Saturday): India Champions vs Australia Champions

    July 26 (Saturday): Pakistan Champions vs West Indies Champions

    July 27 (Sunday): South Africa Champions vs Australia Champions

    July 27 (Sunday): India Champions vs England Champions

    July 29 (Tuesday): Australia Champions vs Pakistan Champions

    July 29 (Tuesday): India Champions vs West Indies Champions

    Knockout Stage

    July 31 (Thursday): Semi-Final 1 – SF1 vs SF4 (Edgbaston Stadium, Birmingham)

    July 31 (Thursday): Semi-Final 2 – SF2 vs SF3 (Edgbaston Stadium, Birmingham)

    August 2 (Saturday): Final (Edgbaston Stadium, Birmingham)

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  • 160 People Wanted to Be Buried in Space. Their Capsule Slammed Into the Ocean Instead.

    160 People Wanted to Be Buried in Space. Their Capsule Slammed Into the Ocean Instead.

    Here’s what you’ll learn when you read this story:

    • A spacecraft called the Nyx capsule recently crashed in the Pacific Ocean after the landing parachutes failed to deploy.

    • The capsule carried cargo including cannabis and human remains, all of which were lost in the crash.

    • After apologizing to the families who lost their loved one’s remains, the company responsible for the spacecraft said this “partial success” should serve as an important learning opportunity for future reusable space flight missions.


    As part of a rideshare mission with SpaceX, the Nyx capsule launched from the Vandenberg Space Force Base on June 23rd. The next day, after successfully re-entering the atmosphere on June 24th, the capsule crashed into the Pacific Ocean and lost some unexpected cargo: cannabis and human remains.

    The Nyx capsule and its launch was part of the program “Mission Possible” led by a German start-up called The Exploration Company (TEC). The launch marks TEC’s second spacecraft to reach orbit in under four years.

    Now, the cannabis plant matter and seeds weren’t for recreational use—they’re part of an open-source citizen science project called Martian Grow. The project seeks to understand the effect of microgravity on germination and resilience, potentially shedding light on how life could survive in non-terrestrial environments.

    The human remains, however, were on the capsule for a much more… wholesome reason: to memorialize loved ones. Celestis—a Texas-based tribute company—provided ashes from over 160 deceased individuals to make the trip into space (sadly, this is not the first time Celestis lost a payload, the first being in 2023 when a rocket carrying a late NASA astronaut’s ashes exploded over New Mexico).

    “We apologize to all our clients who entrusted us with their payloads,” TEC wrote in a statement. “We thank our teams for their hard work and their dedication to success. We have been pushing boundaries in record time and cost. This partial success reflects both ambition and the inherent risks of innovation. Leveraging the technical milestones achieved yesterday and the lessons we will extract from our ongoing investigation, we will then prepare to re-fly as soon as possible.”

    The founder and CEO of TEC, Hélène Huby, also apologized for the lost cargo, suggesting the mission is something the space tech world can grow from.

    “We all hoped for full success; partial success is often part of the road for those who take risks and push boundaries to change the world positively.” she said in a press release. “I take full responsibility and present my apologies to our customers for not achieving full success.”

    TEC explained in the press release that the spacecraft crashed because the landing parachutes failed to deploy. In the same release, the company stated the parachute system wasn’t drop-tested—a risk that “lower costs, shorten development time, and yield a deeper understanding of the vehicle with each flight,” according to TEC. The parachute model had previously been used on SpaceX’s Dragon.

    According to TEC, the recent setback won’t stop their mission—in fact, it’s only helped progress it.

    “We are continuing our journey, eager to implement these learnings in our next vehicle,” Huby said in the press release. “We will learn from Mission Possible and improve, together as a team. I express my profound gratitude to The Exploration Company’s team members who are demonstrating outstanding solidarity, resilience, and commitment to the success of our mission.”

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