Category: 3. Business

  • Impact of Winter Weather on KLM Flights

    Impact of Winter Weather on KLM Flights

    Update January 3, 2:30 PM
    Persistent winter weather conditions are reducing runway capacity at Schiphol. As a result, KLM is forced to cancel 295 flights for January 4. We understand this is inconvenient for our customers. We advise them to keep checking the latest flight information. We are working hard to rebook passengers on the next available flight. We anticipate that these weather conditions will continue and that more cancellations will follow.

    Update January 3, 9:30 AM
    Schiphol is also experiencing disruptions today due to weather conditions: winter weather and an unfavorable wind direction. This has resulted in reduced runway capacity. Other airports in Europe are also dealing with winter weather. Yesterday, KLM had to cancel 114 flights for today. An additional 73 flights have been canceled today. Delays are also expected. We understand this is inconvenient for our customers. We advise them to keep checking the latest flight information. We are working hard to rebook passengers on the next available flight. We anticipate that these weather conditions will persist through the weekend and that more cancellations will follow.

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  • Vatican Governorate releases new app dedicated to St. Carlo Acutis

    Vatican Governorate releases new app dedicated to St. Carlo Acutis

    The Vatican Governatorate releases a new app offering the contents of its official website in a quick and intuitive way, making it possible to consult news, announcements, and official communications.

    Vatican News

    The new official app from the Governorate of the Vatican City State is dedicated to St. Carlo Acutis and his IT skills.

    The application offers the contents of the institutional informational website www.vaticanstate.va and has been designed to make access to information even easier, quicker, and more user-friendly on mobile devices.

    The new app allows users to quickly and intuitively browse news, announcements, and official communications, improving the browsing experience and making the information more accessible.

    Among the main features of the app are updated access to news and institutional communications, push notifications for the latest news, simplified navigation optimized for smartphones and tablets, and better accessibility and usability of content.


    Screenshots of the Vatican Governatorate’s new app

    Features 

    The application includes various sections: the saint of the day, news, interviews, videos, and links connecting to other institutions of the Governorate: CFN, Vatican Museums, Vatican Pharmacy, Vatican Post, Pontifical Villas, Vatican Observatory. Other features will be implemented in the future.

    This initiative is part of the digital innovation path promoted by the Governorate, with the aim of promoting transparency, participation, and the dissemination of institutional information through modern and inclusive tools.

    The new app is now available for free download.

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  • Outbound lanes of Parkway East from Oakland to Squirrel Hill Tunnel reopen after crash

    Outbound lanes of Parkway East from Oakland to Squirrel Hill Tunnel reopen after crash


    A crash shut down the eastbound lanes of the Parkway East in Pittsburgh for a brief period on Saturday morning. 

    According to PennDOT, all of the outbound lanes between the on-ramp from Bates Street at the Oakland interchange to the Squirrel Hill Tunnel were closed to traffic for about half an hour. 

    The crash was cleared, but it’s still unknown how many vehicles were involved.

    Two people had to be taken to the hospital, but their condition is unclear. 

    We’re working to learn what caused the crash. Stay with KDKA.com for the latest.

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  • Nuclear power ventures heat up around Washington state

    Nuclear power ventures heat up around Washington state

    Washington spent much of the 1970s trying to become a center for nuclear power, with plans for five huge fission reactors at Richland and Satsop.

    Then came cost overruns, construction problems, and one of the biggest municipal bond defaults in Wall Street history in 1983.

    Only one of the five proposed reactors of the Washington Public Power Supply System — or WPPSS, commonly pronounced “Whoops” — was finished at Richland. In 1998, WPPSS became Energy Northwest largely to erase the stigma, and completed the 1,150-megawatt reactor that became the Columbia Generating Station.

    Fast forward to today.

    Again, Washington is trying to become a hub for nuclear power. But instead of monster-size reactors, the state is now home to multiple ventures involving smaller reactors — all using technologies unheard of in the 1970s and 1980s.

    Construction at the Satsop Nuclear Power Plant took place in the late 1970s and early 1980s, as seen here. But the Washington Public Power Supply System project was never completed. The nuclear power technology companies are pressing ahead with today is much different than the fission reactors of decades past.

    Courtesy of Washington State Historical Society

    Fusion and small modular reactors are the emerging sources of nuclear power, although both are still fledgling technologies. Policymakers are looking at both. So, too, are some of the nation’s largest tech corporations, eager to find power for electricity-hungry data centers.

    One of the first commercially viable fusion reactors in the U.S. is under construction roughly 6 miles southeast of Wenatchee. It’s expected to be working by 2028, with power going to Microsoft. Fusion reactors are attractive in part because they don’t produce highly radioactive waste.

    Efforts are also underway to develop a different type of fusion reactor in Everett and Richland. These would be small portable units.

    And there are plans for what could be the nation’s second small modular reactor complex at Richland. Amazon is playing a part in that potential undertaking. Small modular reactors are essentially prefabricated mini-versions of traditional fission reactors. They are supposedly faster and cheaper to build than traditional reactors.

    In the works

    Founded in 2013 in Redmond, Helion Energy moved its main lab to Everett and recently began construction in July on a reactor site in the small Chelan County town of Malaga.

    “This is a first-of-its-kind generator,” said Helion co-founder Anthony Pancotti.

    The Malaga complex will house a 50-megawatt fusion reactor called Orion. The plan is for the reactor to deliver power to Microsoft under a contract between the two companies.

    Helion’s long-term plan is to eventually produce more of these reactors to be distributed worldwide, Pancotti said. Helion has roughly 450 employees at Everett and Malaga.

    Construction at the site of Helion’s planned fusion power plant in Malaga, Wash., in Chelan County. The company has a power purchase agreement to provide energy from the facility to Microsoft by 2028. It announced that it had begun work at the site in 2025.

    Construction at the site of Helion’s planned fusion power plant in Malaga, Wash., in Chelan County. The company has a power purchase agreement to provide energy from the facility to Microsoft by 2028. It announced that it had begun work at the site in 2025.

    Courtesy of Helion

    Small portable fusion reactors — about the size of a wine barrel and capable of generating 100 kilowatts — could become a reality in southern Seattle and Richland in a few years.

    “What we are going for is mobile power,” said Brian Riordan, cofounder of Avalanche Energy, a company based in the Seattle area that is developing space and underwater fusion reactors.

    Initial customers would likely buy the mini-reactors for military satellites and unmanned underwater vehicles. Riordan hopes to sell Avalanche’s first 100-kilowatt reactor before 2030.

    The company plans to branch out into other uses, for portable power generators, with Riordan noting that the fusion device needs to produce electricity cheaper than what is created by wind and solar power options.

    Avalanche’s headquarters and research facilities are near Boeing Field. The company recently leased a Port of Benton facility in northern Richland for an operation called FusionWERX.

    “FusionWERX is going to be the fusion industry’s equivalent of a commercial wind tunnel — an open-access facility where new ideas, technologies, and components can be tested and validated,” Avalanche’s CEO, Robin Langtry, said in a statement.

    Avalanche has roughly 70 employees split between Seattle and Richland.

    Another company, X-energy, signed agreements last year with Amazon and Energy Northwest for the retail giant to invest $334 million to study putting four modular reactors on the site of the half-built WPPSS Reactor No. 1, which is next to the Columbia Generating Station.

    This piece of federal land gives the project the advantage of existing infrastructure, including roads and utilities from the 1980s.

    Amazon’s interest is prompted by its plans to build data centers.

    The four-reactor proposal — dubbed the “Cascade Advanced Energy Facility” — would produce 320 megawatts, with the possibility of adding more reactors to reach 960 megawatts.

    A rendering released last year of the Cascade Advanced Energy Facility, which could end up being the first small modular reactor facility in the Pacific Northwest.

    A rendering released last year of the Cascade Advanced Energy Facility, which could end up being the first small modular reactor facility in the Pacific Northwest.

    Courtesy of Energy Northwest

    Energy Northwest has been doing environmental, safety and legal reviews on the proposal. Construction is tentatively set to begin at the end of this decade.

    Amazon has tentative plans to work with X-energy to build small modular reactors across the nation by 2039 that would collectively produce 5,000 megawatts of power.

    ‘The world’s leading hub for fusion’

    The concept of fusion has been around for roughly a century. Right now, around 40 fusion development projects using different technologies exist worldwide, while no commercially viable fusion reactors are currently producing electricity.

    A huge hurdle is that the amount of electricity needed to create a fusion reaction is greater than the power that would be produced. In 2022, the Lawrence Livermore National Laboratory in California used lasers to produce surplus electricity.

    Shortly afterward, Helion Energy achieved that same goal with a setup that slams two atoms together.

    Practical fusion is so new that the U.S. Nuclear Regulatory Commission — which routinely takes years to approve new designs for fission reactors — currently does not regulate fusion devices.

    Consequently, Helion and Avalanche do not need the commission’s approval for their devices. Instead, they obtain permits from the state and their host counties.

    That will likely change soon. Last July, the Nuclear Regulatory Commission sent a report to Congress on how it should license fusion devices.

    Related: To meet growing energy demand, Oregon is ‘nuclear curious,’ mostly cautious

    On Oct. 31, U.S. Sen. Maria Cantwell and U.S. Rep. Suzan DelBene, both Washington Democrats, along with other congressional members of both parties, announced the introduction of a bill to provide tax credits for fusion-related ventures.

    “The state of Washington is the world’s leading hub for fusion energy, which one day could provide vast amounts of the type of power we need to keep electricity prices down and increase America’s economic competitiveness,” Cantwell said in a press release.

    Then, in November, the U.S. Department of Energy created an Office of Fusion as the Trump administration moved away from renewable energy, such as wind and solar power, in order to shift money to nuclear and fossil fuel development.

    Fusion leaders met with the Energy Department on Dec. 9 to lobby for federal support for fusion.

    “Now is the time for the U.S. to make a significant investment, and that means over a billion dollars per year in annual appropriations and a one-time infrastructure investment,” Andrew Holland, CEO of the Fusion Industry Association, said at the time, according to Reuters.

    Pacific Northwest National Laboratory, a huge federal lab in northern Richland, is beginning two fusion-related materials projects. Materials are critical as, during operation, components of fusion reactors can reach temperatures hotter than the sun.

    The Tri-Cities area has deep roots and a strong workforce in the nuclear sector, tracing back to the Manhattan Project in 1943.

    Consequently, this region has great interest in new types of reactors, the fusion industry, and clean energy projects, said David Reeploeg, head of federal relations for the Tri-City Development Council, and Sean O’Brien, executive director of the council’s clean energy spinoff called the Energy Forward Alliance.

    The Tri-Cities, which include Kennewick, Pasco, and Richland, are also looking at attracting data centers with local nuclear power and having a long-time nuclear fuel assembly plant expand the types of fuel it can offer, Reeploeg and O’Brien said.

    “The key focus for us is keeping our workforce employed,” O’ Brien said.

    Related: Nuclear energy push stalls out, but opponents sense a ‘shift’ in Oregon

    Modular designs

    Small modular reactors are like prefabricated houses. There are locked-in designs and pre-built components, which are then taken to a site and assembled. Small modular reactors are designed so extra modules can be added as needed. This concept is supposed to lead to lower costs, faster construction and more flexibility.

    Each modular unit would be a mini-reactor capable of generating 50 to 300 megawatts of energy.

    Some U.S. and world leaders are pushing this new nuclear reactor as a carbon-emissions-free power technology to combat climate change.

    NuScale Power, based in Corvallis, Oregon, is the only U.S. venture so far to receive Nuclear Regulatory Commission approval for its small modular reactor design.

    The company obtained a contract to build a modular reactor complex at Idaho Falls for Utah Associated Municipal Power Systems, which is part of the Utah state government and provides electricity to four states.

    However, many of that project’s prospective customers dropped out, and the project was canceled in 2023.

    A diagram showing the basics of a small modular reactor unit.

    A diagram showing the basics of a small modular reactor unit.

    Courtesy of U.S. Department of Energy

    A 2022 Stanford University study raised questions about contamination from used nuclear fuel from small modular reactors. It looked at NuScale’s designs, as well as designs from two other companies submitted to the federal government. Not among them was X-energy’s, the company involved in the project with Energy Northwest and Amazon. The study picked NuScale’s design because it was the furthest along in the federal review process.

    The Stanford study concluded that NuScale’s design and the two others would produce greater volumes of radioactive waste than conventional reactors, and that the used reactor fuel would be roughly 50% more radioactive.

    NuScale contested those conclusions, saying the Stanford study looked at outdated designs.

    State legislation teed up

    Two Republican Washington state legislators — with high-ranking Democratic cosponsors — have introduced similar 2026 nuclear fission power reactor bills in the Senate and House.

    The bills, which do not mention fusion power, call for developing a nuclear power development master plan for Washington state by Dec. 15, 2026. Introduced by Sen. John Braun, R-Centralia and Rep. Stephanie Barnard, R-Pasco, the legislation points to signs that Washington’s push for alternative power sources might not meet the state’s needs.

    Washington is a net exporter of electricity, but the state government predicts it will be a net importer of power by 2050. Meanwhile, Montana and Wyoming were expected to send wind and solar power to Washington in the next few decades. But the legislation says that those power sources now look less promising.

    The proposed report would address future fission power reactor goals, plus what various governments and utilities should do. It would also look at financing, siting, consulting with tribes, workforce requirements, and regulatory needs.

    Washington State Standardis part of States Newsroom, a network of news bureaus supported by grants and a coalition of donors as a 501(c)(3) public charity.

    This republished story is part of OPB’s broader effort to ensure that everyone in our region has access to quality journalism that informs, entertains and enriches their lives. To learn more, visit opb.org/partnerships.

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  • What will it take to boost housing in N.L.? This advocate says a focused approach and targeted investing

    What will it take to boost housing in N.L.? This advocate says a focused approach and targeted investing

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    Newfoundland and Labrador needs more houses, and one advocate says it’s going to take a multi-pronged approach to boost construction.

    Kelly Rogers, an executive with the Canadian Home Builders Association’s Newfoundland and Labrador branch, said the latest data from the Canada Mortgage and Housing Corporation shows new housing construction in the province as “mixed.”

    “It’s generally showing a positive year-to-date trend in urban areas, despite some recent monthly volatility. The year-to-date housing starts from January to October … it was 880 units,” she told CBC News.

    In 2012, when the housing construction sector was “booming,” she said housing starts were 3,885.

    “We’re a long way from those steps,” Rogers said.

    There are a number of factors that can depress housing affordability and supply, she said, like higher interest rates, restrictive mortgage rules, development changes, red tape, as well as labour shortages.

    Over the summer, Prime Minister Mark Carney announced a GST rebate for first time home buyers, something Rogers said would result in significant savings for those customers. However, the bill wasn’t passed.

    ‘A huge feat’

    A 2024 Canada Mortgage and Housing Corporation report estimated Newfoundland and Labrador needed 60,000 new housing units built in the next six years, which would mean 10,000 new homes a year.

    “That’s quite significant and it is a huge feat, for sure,” said Rogers.

    During the recent provincial election, the Progressive Conservatives pledged to build 10,000 homes over five years.

    Rogers said to ramp up construction there needs to be targeted investment in housing to improve infrastructure. A big barrier to construction outside of St. John’s is municipal water, sewer and road systems capacity, she said.

    “We also need to remove the barriers to factory built homes, one of which includes financial institutions not offering proper construction financing products for modular homes,” Rogers said.

    Man standing in front of two microphones
    Housing Minister Joedy Wall says the province is looking at different types of housing builds, including modular homes and micro-units. (Julia Israel/CBC)

    The recently passed federal budget earmarked an initial $13 billion over the next five years to “supercharge” the housing industry, with money for developing factory-built housing and other affordable home options.

    “There’s still all kinds of regulations in place. It’s not as easy as just saying, ‘OK, let’s build 1,000 modular homes.’ There’s so many barriers to that,” Rogers said.

    Red tape a ‘major focus’

    Housing Minister Joedy Wall said building 10,000 homes in the next few years is an “ambitious goal” but the new Progressive Conservative government is ready for it.

    Wall said reducing red tape for municipalities will be a “major focus we’re going to be looking at,” adding — as a former mayor — he understands different towns have different regulations.

    “At the [Municipalities Newfoundland and Labrador] event in Corner Brook just a couple of weeks back … many towns want to have the chat, wanting to be part of the solution, which is great because as a provincial government we cannot do this alone,” he said.

    Wall said the province is also looking at different types of builds, modular homes and micro-units.

    Wall, who was speaking during a ground-breaking ceremony for a Habitat Humanity duplex in Mount Pearl at the time, said he hadn’t spoken with his federal colleagues on how federal initiatives could help the province boost its housing supply.

    Download our free CBC News app to sign up for push alerts for CBC Newfoundland and Labrador. Sign up for our daily headlines newsletter here. Click here to visit our landing page.

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  • Elon Musk promised a ‘major rebound’ for Tesla in 2025. Instead it fell behind its biggest rival from China

    Elon Musk promised a ‘major rebound’ for Tesla in 2025. Instead it fell behind its biggest rival from China

    Tesla lost its crown as the world’s bestselling electric vehicle maker on Friday as a customer revolt over Elon Musk’s right-wing politics, expiring U.S. tax breaks for buyers and stiff overseas competition pushed sales down for a second year in a row.

    Tesla said that it delivered 1.64 million vehicles in 2025, down 9% from a year earlier.

    Chinese rival BYD, which sold 2.26 million vehicles last year, is now the biggest EV maker.

    It’s a stunning reversal for a car company whose rise once seemed unstoppable as it overtook traditional automakers with far more resources and helped make Musk the world’s richest man. The sales drop came despite President Donald Trump’s marketing effort early last year when he called a press conference to praise Musk as a “patriot” in front of Teslas lined up on the White House driveway, then announced he would be buying one, bucking presidential precedent to not endorse private company products.

    For the fourth quarter, Tesla sales totaled 418,227, falling short of even the much reduced 440,000 target that analysts recently polled by FactSet had expected. Sales were hit hard by the expiration of a $7,500 tax credit for electric vehicle purchases that was phased out by the Trump administration at the end of September.

    Tesla stock fell 2.6% to $438.07 on Friday.

    Even with multiple issues buffeting the company, investors are betting that Tesla CEO Musk can deliver on his ambitions to make Tesla a leader in robotaxi services and get consumers to embrace humanoid robots that can perform basic tasks in homes and offices. Reflecting that optimism, the stock finished 2025 with a gain of approximately 11%.

    The latest quarter was the first with sales of stripped-down versions of the Model Y and Model 3 that Musk unveiled in early October as part of an effort to revive sales. The new Model Y costs just under $40,000 while customers can buy the cheaper Model 3 for under $37,000. Those versions are expected to help Tesla compete with Chinese models in Europe and Asia.

    For fourth-quarter earnings coming out in late January, analysts are expecting the company to post a 3% drop in sales and a nearly 40% drop in earnings per share, according to FactSet. Analysts expect the downward trend in sales and profits to eventually reverse itself as 2026 rolls along.

    Musk said earlier last year that a “major rebound” in sales was underway, but investors were unruffled when that didn’t pan out, choosing instead to focus on Musk’s pivot to different parts of business. He has has been saying the future of the company lies with its driverless robotaxis service, its energy storage business and building robots for the home and factory — and much less with car sales.

    Tesla started rolling out its robotaxi service in Austin in June, first with safety monitors in the cars to take over in case of trouble, then testing without them. The company hopes to roll out the service in several cities this year.

    To do that successfully, it needs to take on rival Waymo, which has been operating autonomous taxis for years and has far more customers. It also will also have to contend with regulatory challenges. The company is under several federal safety investigations and other probes. In California, Tesla is at risk of temporarily losing its license to sell cars in the state after a judge there ruled it had misled customers about their safety.

    “Regulatory is going to be a big issue,” said Wedbush Securities analyst Dan Ives, a well-known bull on the stock. “We’re dealing with people’s lives.”

    Still, Ives said he expects Tesla’s autonomous offerings will soon overcome any setbacks.

    Musk has said he hopes software updates to his cars will enable hundreds of thousands of Tesla vehicles to operate autonomously with zero human intervention by the end of this year. The company is also planning to begin production of its AI-powered Cybercab with no steering wheel or pedals in 2026.

    To keep Musk focused on the company, Tesla’s directors awarded Musk a potentially enormous new pay package that shareholders backed at the annual meeting in November.

    Musk scored another huge windfall two weeks ago when the Delaware Supreme Court reversed a decision that deprived him of a $55 billion pay package that Tesla doled out in 2018.

    Musk could become the world’s first trillionaire later this year when he sells shares of his rocket company SpaceX to the public for the first time in what analysts expect would be a blockbuster initial public offering.

    ____

    AP video journalist Mustakim Hasnath contributed to this report from London.

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  • Former Greengates bank to be converted into cafe and shop

    Former Greengates bank to be converted into cafe and shop

    A former bank is to be converted into a cafe and shop despite multiple objections.

    Developers were granted permission to convert the former NatWest bank in Greengates by Bradford Council in December, despite receiving 12 objections.

    The building on New Line, which is next to a pharmacy and Asda, has been vacant for more than a year, according to the council.

    Residents objecting to the plans said they were concerned about the negative impact on property values, potential damage to local businesses and an increase in parking.

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  • Ethiopia strikes draft restructuring deal on $1 billion bond with bondholder group – Reuters

    1. Ethiopia strikes draft restructuring deal on $1 billion bond with bondholder group  Reuters
    2. Ethiopia nears $1b bond restructuring  The Express Tribune
    3. Ethiopia reaches agreement in principle with Ad Hoc Committee of bondholders on principal financial terms of restructuring of 2024 Notes- Ministry of Finance – Addis Media Network -English  አዲስ ሚዲያ ኔትወርክ
    4. BREAKING NEWS: Ethiopia Reaches Deal in Principle on $1bln Eurobond  Birr Metrics
    5. News: #Ethiopia reaches preliminary deal with bondholders on restructuring of 2024 #Eurobond Ethiopia has reached an agreement in principle with a group of international bondholders on the main financial terms for restructuring its US$1 billion Eurobond th  facebook.com

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  • SLLEA AC/DC Adapter for Le Pan Mini TC802A TC802 Android Touch Screen Tablet Power Supply Cord Cable PS Charger Mains PSU

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    Product Description

    SLLEA AC / DC Adapter For Le Pan mini TC802A TC802 Android Touch Screen Tablet Power Supply Cord Cable PS Charger Mains PSU

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  • The OncFive: Top Oncology Articles for the Week of 12/28

    The OncFive: Top Oncology Articles for the Week of 12/28

    Welcome to OncLive®’s OncFive!

    Every week, we bring you a quick roundup of the 5 top stories from the world of oncology—ranging from pivotal regulatory decisions to key pipeline updates to expert insights on breakthroughs that are moving the needle in cancer care. This resource is designed to keep you informed on the latest updates in the space, in just a matter of minutes.

    Here’s what you may have missed this week:

    The FDA approved narsoplimab-wuug (Yartemlea) for the treatment of adults and pediatric patients aged 2 years or older with hematopoietic stem cell transplant–associated thrombotic microangiopathy (TA-TMA). The decision was supported by single-arm TA-TMA Study and expanded access program data showing a TMA complete response (CR) rate of 61% in evaluable patients, with consistent responses across adult and pediatric cohorts. Treatment led to improvements in platelet count, lactate dehydrogenase levels, organ function, and transfusion independence, with a 100-day survival rate of approximately 73% from TMA diagnosis. This marks the first FDA-approved therapy for TA-TMA, representing a practice-changing advance in post-transplant supportive care.

    A new drug application has been submitted to the FDA seeking approval of bezuclastinib (CGT0486) for use in patients with nonadvanced systemic mastocytosis, based on positive results from the phase 2 SUMMIT trial (NCT05186753). Bezuclastinib significantly improved total symptom score at week 24 compared with placebo and led to higher rates of clinically meaningful symptom reduction. The agent also showcased marked biologic activity, with over 95% of evaluable patients achieving at least a 50% reduction in serum tryptase levels. These data support bezuclastinib as a potential disease-modifying therapy in a population with limited approved options.

    China’s National Medical Products Administration approved ipilimumab N01 (IBI310; Tabosun) in combination with sintilimab (Tyvyt) as neoadjuvant therapy for patients with stage IIB to III resectable microsatellite instability–high/mismatch repair–deficient colon cancer. The decision was supported by data from the phase 3 NeoShot study (NCT05890742) demonstrating an 82% pathological CR (pCR) rate with the combination versus surgery alone, without increased surgical risk. Earlier phase 1b results showed significantly higher pCR rates with ipilimumab N01 plus sintilimab vs sintilimab monotherapy. This represents the world’s first approval of a CTLA-4 antibody in the neoadjuvant colon cancer setting.

    Japan’s Ministry of Health, Labour and Welfare approved tafasitamab-cxix (Minjuvi) plus rituximab (Rituxan) and lenalidomide (Revlimid) for the treatment of adults with relapsed or refractory follicular lymphoma. The decision was based on findings from the phase 3 inMIND trial (NCT04680052), which showed a significant progression-free survival (PFS) benefit over placebo plus rituximab and lenalidomide, at a median PFS of 22.4 months vs 13.9 months (HR, 0.43). Independent review confirmed durable PFS benefit, with median PFS not reached in the tafasitamab arm. This approval establishes a chemotherapy-free, dual CD19/CD20–targeted option in Japan for relapsed/refractory disease.

    In December 2025, the FDA issued multiple oncology approvals, including full approval of pirtobrutinib (Jaypirca) for relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma based on findings from BRUIN CLL-321 (NCT04666038) and clearance of lisocabtagene maraleucel (Breyanzi) for relapsed/refractory marginal zone lymphoma based on data from TRANSCEND-FL (NCT04245839). Additional approvals included niraparib plus abiraterone (Akeega) for BRCA2-mutated metastatic castration-sensitive prostate cancer based on findings from AMPLITUDE (NCT04497844) and fam-trastuzumab deruxtecan-nxki (Enhertu) plus pertuzumab (Perjeta) for frontline HER2-positive metastatic breast cancer based on data from DESTINY-Breast09 (NCT04784715). The agency also expanded access to subcutaneous formulations of amivantamab and hyaluronidase-lpuj (Rybrevant Faspro) and mosunetuzumab (Lunsumio VELO), improving treatment convenience without compromising efficacy. Collectively, these decisions reflect continued momentum toward precision oncology, novel drug delivery platforms, and earlier use of targeted and cellular therapies.

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