Category: 3. Business

  • Europeans shunning US as Emirates and Asia travel prove popular, says Tui | Travel & leisure

    Europeans shunning US as Emirates and Asia travel prove popular, says Tui | Travel & leisure

    Europeans are booking fewer trips to the US, Europe’s biggest travel operator has said, as appetite for long-haul travel wanes and concerns linger around Donald Trump’s immigration policies.

    Tui, which receives most of its bookings from customers in Europe, has seen “significantly lower demand” for travel into the US, according to its chief executive, Sebastian Ebel.

    “What we do see is growing business to the Emirates and Asia,” he said. “We also see European demand to the Caribbean, which – due to capacity – had not been the biggest priority in the past, but there we see now potential again to grow.”

    It comes amid signs that demand for long-haul travel across the Atlantic is waning.

    A report by the European Travel Commission, which surveyed travellers from Australia, Brazil, Canada, China, Japan, South Korea and the US, found 42% of long-haul travellers were considering a trip to Europe this year, down from 45% last year. In the US, only 34% intended to travel to Europe, down from 37%.

    In Europe, several countries have issued advisories about travel to the US owing to stricter border scrutiny, the detention of some visitors and protests over the Immigration and Customs Enforcement (ICE) agency.

    Since Trump took office, reports have emerged from US border of tourists being detained and interrogated, people with work permits sent to ICE detention centres and people being wrongly deported.

    Overseas visits to the US from western Europe were down 4% in December compared with the same month last year, according to the US National Travel and Tourism Office.

    Last year, Ebel said Tui had seen a “significant decline” in travel to the US, owing to a multitude of factors including “the atmosphere, what you hear from border control”.

    While demand for US holidays has been weaker, Tui hailed its best first quarter in just over a decade.

    The German travel operator, which is headquartered in Hanover and employs about 67,000 people around the world, reported a 1% rise in revenue to €4.9bn (£4.3bn) in the quarter ending in December, and a 7.5% rise in operating profit to €72.9m.

    Aarin Chiekrie, an analyst at the investment broker Hargreaves Lansdown, said much of the success came from its cruise business, where profits rose by more than 70%.

    “Consumers continue to prioritise travel, which has seen Tui’s occupancy rates rise despite its fleet expansion,” he said. “All other business segments saw profitability improve over the period, except hotels and resorts, which suffered a double-digit decline due to losses resulting from the Jamaican hurricane, and the non-repeat of some one-off benefits last year.”

    Shares in Tui, which is listed in Frankfurt, ticked up 0.4% in early trading on Tuesday. The stock has risen by about 10% in the past year.

    Continue Reading

  • Fireblocks and Thales Expand Collaboration to Deliver Bank-Grade Digital Asset Security

    Fireblocks and Thales Expand Collaboration to Deliver Bank-Grade Digital Asset Security

    Collaboration enables regulated institutions to deploy digital asset services using certified, customer-owned hardware within existing compliance frameworks

    SINGAPORE, Feb. 10, 2026 /PRNewswire/ — Fireblocks, the enterprise platform securing more than $5 trillion in digital asset transfers annually, today announced an expanded collaboration with Thales, a global leader in cybersecurity and trusted provider of Luna Hardware Security Modules (HSMs), to deliver institutional-grade digital asset security architecture for financial institutions.

    The collaboration integrates Fireblocks’ digital asset platform with Thales’ Luna HSMs, enabling institutions to extend their existing certified hardware infrastructure into digital asset operations without re-architecting security models or compromising regulatory compliance.

    The architecture supports a wide range of institutional use cases, including custody, trading, tokenization, and onchain settlement, while integrating with existing security, governance, and audit processes. Organizations can securely manage cryptocurrencies, stablecoins, security tokens, and tokenized real-world assets across major blockchain networks – with support for multiple elliptic curves enabling broader cross-chain coverage and deeper liquidity.

    Unlike solutions that rely on opaque security models, Fireblocks provides banks and financial institutions with complete policy control and final authority over transactions – meeting regulatory expectations for accountability and clear governance. The joint solution maps security controls directly to compliance requirements through customer-owned Luna HSMs, multi-party computation (MPC), and cross-domain integrations that regulators understand and can assess for operational risk.

    This control is operationalized through Fireblocks KeyLink, which ensures private keys or key shares are generated, stored, and operated entirely within customer-owned Luna HSMs. All cryptographic operations are performed inside institution-controlled infrastructure – Fireblocks cannot unilaterally sign transactions or move assets. Instead, the platform provides policy enforcement, orchestration, and enterprise-grade governance across hot, warm, and cold operating models.

    Todd Moore, Vice President, Data Security Products at Thales, commented, “As digital assets reshape global finance, adoption will depend on a proven foundation of trust. Thales provides that foundation with Luna HSMs, protecting and controlling the cryptographic keys that underpin ownership and transaction authority. Combined with Fireblocks, we help institutions reduce key-exposure risk, strengthen governance, and move digital value with confidence across high-value digital ecosystems at scale.”

    “As banks and financial institutions accelerate production deployments as well as proofs-of-concept, they need digital asset infrastructure that aligns with the same governance, audit, and risk principles that underpin traditional financial infrastructure,” said Adam Levine, SVP, Head of Corporate Development and Partnerships at Fireblocks. “By expanding our partnership with Thales, we’re enabling the deployment of digital asset services using customer-owned, certified hardware they already trust – without compromising on control, compliance, or operational integrity.”

    Designed to handle institutional transaction volumes at scale, Fireblocks delivers the operational resilience and continuous availability that regulators require from mission-critical financial systems. With over 95 banks already using the platform in live environments, Fireblocks enables institutional digital asset adoption grounded in proven performance, regulatory alignment, and verifiable trust.

    To find out more about how to secure digital asset private keys in customer-owned certified Luna HSMs, join the webinar on 3rd March 2026: https://bit.ly/4an5zSu

    About Fireblocks

    Fireblocks is the world’s most trusted digital asset infrastructure company, empowering organizations of all sizes to build, manage and grow their business on the blockchain. With the industry’s most scalable and secure platform, we streamline stablecoin payments, settlement, custody, tokenization, and trading operations enabling – everything from institutional finance to consumer-facing digital experiences across the largest ecosystem of banks, payment providers, stablecoin issuers, exchanges and custodians. Thousands of organizations – including Worldpay, BNY, Galaxy, and Revolut – trust Fireblocks to secure more than $10 trillion in digital asset transactions across 150+ blockchains. Learn more at fireblocks.com

    About Thales

    Thales (Euronext Paris: HO) is a global leader in advanced technologies for the Defence, Aerospace, and Cyber & Digital sectors. Its portfolio of innovative products and services addresses several major challenges: sovereignty, security, sustainability and inclusion.

    The Group invests more than €4 billion per year in Research & Development in key areas, particularly for critical environments, such as Artificial Intelligence, cybersecurity, quantum and cloud technologies.

    Thales has more than 83,000 employees in 68 countries. In 2024, the Group generated sales of €20.6 billion.

    SOURCE Fireblocks

    Continue Reading

  • Oil major BP suspends buybacks in fresh sign of oil price pressure

    Oil major BP suspends buybacks in fresh sign of oil price pressure

    Trowbridge in Somerset, England, on March 15, 2025.

    Anna Barclay | Getty Images News | Getty Images

    British oil giant BP on Tuesday posted fourth-quarter profit in line with expectations and suspended share buybacks, seeking to shore up its balance sheet as lower crude prices take their toll.

    The London-listed energy firm reported underlying replacement cost profit, used as a proxy for net profit, of $1.54 billion for the final three months of 2025. That matched analyst expectations of $1.54 billion, according to an LSEG-compiled consensus.

    BP’s full-year 2025 net profit came in at $7.49 billion, missing analyst expectations of $7.58 billion. That’s down from nearly $9 billion in 2024.

    BP said the board decided to suspend the share buyback and fully allocate excess cash “to accelerate strengthening” of its balance sheet.

    “2025 was a year of strong underlying financial results, strong operational performance, and meaningful strategic progress,” Carol Howle, BP interim chief executive officer, said in a statement.

    “We have made progress against our four primary targets – growing cash flow and returns, reducing costs, and strengthening the balance sheet – but know there is more work to be done, and we are clear on the urgency to deliver,” she added.

    The results come at a tough time for Europe’s oil and gas sector.

    Oil prices notched their biggest annual loss since the Covid-19 pandemic last year, partly due to oversupply concerns, ratcheting up the pressure on Big Oil’s commitment to shareholder returns.

    BP’s industry rivals Equinor and Shell both reported weaker quarterly earnings last week, citing lower crude prices, among other factors.

    Equinor announced it would reduce share buybacks to $1.5 billion this year, down from $5 billion last year, while also trimming investments in its renewables and low-emission energy projects.

    Shell, for its part, kept its buybacks steady at $3.5 billion, a move that marked the firm’s 17th consecutive quarter of $3 billion or more in buybacks.

    This is breaking news. Please refresh for updates.

    Continue Reading

  • Access Denied


    Access Denied

    You don’t have permission to access “http://www.alvarezandmarsal.com/thought-leadership/saudi-arabia-tax-alert-amendments-to-the-excise-tax-implementing-regulations-december-2025” on this server.

    Reference #18.cfb31402.1770704362.41a9157b

    https://errors.edgesuite.net/18.cfb31402.1770704362.41a9157b

    Continue Reading

  • An agency subscription model takes shape at S4 Capital

    An agency subscription model takes shape at S4 Capital

    Subscriptions were supposed to save publishers. Now, they’re becoming part of the survival logic for agencies too.

    At agency holdco S4 Capital, the pivot is already taking shape.

    By the end of the year, about a quarter of revenue at its Monks arm is expected to come from what it calls subscriptions — not in the Netflix sense but as a commercial model where, instead of selling hours, the agency sells ongoing access to a bundle that combines senior talent, AI workflows, agents and institutional knowledge for a steady, recurring fee.

    Those agreements typically run for at least a year, with the heavy early lift of setting it all up folded into the subscription rather than billed as a one-off project, even as the tools and systems behind the work continue to improve over time.

    From there, the deal works less like a fixed checklist of tasks and more like a service that gets better over time. As the AI system improves, the agency can produce more work or do it faster without having to rewrite the contract. Those efficiency gains don’t show up as fewer hours billed, they show up as more output inside the same fee.

    As Monks’ co-founder and chief AI officer Wesley ter Haar put it, something that once delivered “50 of these [outputs] a month” might reach 70 as models get better and pipelines get smarter, creating ongoing value within the same commercial contract.

    “With the hunger for compute about to explode do we then have to add pass through [costs], which in an ideal world, as an agency, you don’t want to do because it complicates the ability for a client to sign off on a contract if you have every variable as a pass through cost. Procurement teams hate that. So we try and wrap that up into our subscription model,” said ter Haar.

    Clearly this stops well short of the outcome-based structure agency CEOs describe as the endgame. At most, subscriptions are a waypoint. The pressure behind them is more concrete. AI now handles work that used to take junior staff hours, while also introducing new, less visible costs in the form of model usage and compute. In that environment, charging by the hour fits the work less and less, pushing agencies toward models that reflect systems rather than time.

    “Just like software, the subscription gets upgrades, which is why we say it’s ongoing,” said ter Haar.

    Those upgrades play out across two interlocking tiers within the bundle.

    On the human side, AI is absorbing more junior-heavy production, giving clients greater access to senior operators with more flexibility in how time is deployed. Hours allocated for one quarter can roll into the next, allowing the work to follow momentum rather than the calendar.

    Alongside that sits the machine layer: repeatable marketing workflows powered by LLM-driven agents handling both standardized and bespoke tasks, supported by tiered knowledge bases that combine task logic, client data and broader industry intelligence. Together, these systems compress research and production time, even as most work remains under a people-in-the model rather than fully autonomous execution.

    “The billable hour does not allow for any meaningful innovation, which clients understand,” said ter Haar. “They’re open to new models.”

    So far one client has brought into it since last fall, and two more are expected to follow before the quarter closes.

    “My goal for this year is to have about 25% of our revenue running in this model, and that is based on hopefully having three quite sizable clients signed up at the end of Q1 and then having a decent amount of new business that starts in that space,” said ter Haar.

    What happens after that depends less on vision than mechanics. AI usage must remain economically manageable as tokens and inference costs fluctuate. Agencies have to decide whether to absorb or expose those tech expenses. Clients and procurement teams must accept a model that behaves differently from traditional scopes. At the same time, large legacy contracts inside organizations still built around billable hours have to unwind slowly enough for both sides to adjust. There’s also the structural risk in tying pricing too closely to raw AI consumption. The very technology meant to make work more efficiently can introduce volatility that neither side fully controls, complicating efforts to make the model feel predictable. 

    “Token costs are falling while usage is exploding — it’s an unstable foundation,” said Robert Webster, founder of AI marketing consultancy TAU Marketing Solutions. “It would be wrong for an agency to try to arbitrate that situation. Yes, AI usage is going to be really important as are the subsequent inference costs that it generates but I fear getting stuck in a world where large parts of the industry charge an arbitrage on tokens.”

    Continue Reading

  • NTT DATA Acquires Zero&One to Accelerate Cloud Growth across the Middle East

    NTT DATA Acquires Zero&One to Accelerate Cloud Growth across the Middle East

    February 10, 2026

    NTT DATA, Inc.

    DUBAI – 10 February 2026NTT DATA, a global leader in AI, digital business and technology services, has acquired Zero&One, the first homegrown Amazon Web Services (AWS) Premier Tier Services Partner in the Middle East and North Africa (MENA). The acquisition significantly strengthens NTT DATA’s cloud capabilities and positions it to tap into the rapidly expanding Middle East cloud services market.

    Founded in 2017 and headquartered in Dubai, Zero&One is a leading regional cloud consultancy. The company holds nine AWS competencies and was the first in the MENA to achieve AWS Generative AI Competency. In 2025, Zero&One was named AWS’s MENA Consulting Partner of the Year and received the Rising Star Partner of the Year and Design Partner of the Year awards at the EMEA level.

    The acquisition supports NTT DATA’s regional growth ambitions as the Middle East cloud market enters a period of significant growth, e.g. Saudi Arabia’s cloud services market was valued at $4.77 billion last year and is expected to more than double by the early 2030s, with AWS set to open its first data center there in 2026.

    “This acquisition enables us to deliver high-impact solutions and enhance the value we bring to organizations in the Middle East. Zero&One’s expertise strengthens our ability to deliver the speed, scale and technical depth clients need in today’s cloud-first environment,” said Burcak Soydan, Managing Director for the Middle East at NTT DATA.

    “Joining NTT DATA is the natural next step in our growth journey,” said Ali El Kontar, CEO of Zero&One. “We’ve built our reputation on delivering world-class cloud expertise to organizations across the Middle East. As part of NTT DATA, we can now combine our regional knowledge and AWS specialization with global resources, expanded service offerings and the ability to support clients on an even larger scale. Our teams share a commitment to innovation and client success, making this an ideal partnership”

    The acquisition enables NTT DATA to offer comprehensive cloud services to Middle East and African clients, including cloud migration, application modernization, cloud-native development, data analytics and AI solutions.

    About NTT DATA

    NTT DATA is a $30+ billion business and technology services leader, serving 75% of the Fortune Global 100. We are committed to accelerating client success and positively impacting society through responsible innovation. We are one of the world’s leading AI and digital infrastructure providers, with unmatched capabilities in enterprise-scale AI, cloud, security, connectivity, data centers and application services. Our consulting and industry solutions help organizations and society move confidently and sustainably into the digital future. As a Global Top Employer, we have experts in more than 70 countries. We also offer clients access to a robust ecosystem of innovation centers as well as established and start-up partners. NTT DATA is part of NTT Group, which invests over $3 billion each year in R&D.
    Visit us at nttdata.com

    About Zero&One

    Zero&One is the first homegrown AWS Premier Tier Services Partner in the MENA region, specializing in cloud-native services and solutions including application modernization, cloud operations, AI and machine learning and data analytics. Founded in 2017 and headquartered in Dubai, the company serves clients across multiple industries including financial services, retail, media and entertainment, healthcare and government. Zero&One holds nine AWS competencies and was the first in MENA to achieve AWS Generative AI Competency. For more information, visit www.zeroandone.me

    Continue Reading

  • Issue of S$500 million notes by Singapore Airlines Limited: Allen & Gledhill

    Issue of S$500 million notes by Singapore Airlines Limited: Allen & Gledhill










    9 February 2026

    Allen & Gledhill advised Singapore Airlines Limited (“SIA”) on the issue of S$500 million notes under its S$10 billion multicurrency medium term note programme.

    Advising SIA were Allen & Gledhill Partners Margaret Chin and Sunit Chhabra.

    Continue Reading

  • China Hazardous Chemical Safety Compliance Management Forum (March 11) – Events – Chemicals

    China Hazardous Chemical Safety Compliance Management Forum (March 11) – Events – Chemicals


    from CIRS
    by

    The Hazardous Chemicals Safety Law of the People’s Republic of China will take effect on May 1, 2026. This legislation comprehensively strengthens the primary responsibility of enterprises involved in hazardous chemicals, elevates compliance requirements across the entire supply chain, strictly controls licensing access, increases penalties for violations, and enhances interdepartmental regulatory coordination and enforcement collaboration. It will bring systemic and profound impacts and challenges to hazardous chemicals production and operation enterprises, as well as relevant parties such as universities and research institutions. To assist enterprises in anticipating policy trends and accurately grasping compliance essentials, the “Hazardous Chemicals Safety Compliance Management Forum” will convene in Shanghai on March 11, 2026. Hosted by the China Warehousing and Distribution Association, co-organized by the Association of International Chemical Manufacturers (AICM) and Hangzhou REACH Technology Group Co., Ltd., and undertaken by the Hazardous Materials Branch of the China Warehousing and Distribution Association.

    Highlights

    • Authoritative Interpretation of New National Laws and Standards with Implementation Highlights
    • Latest Trends in Customs Import/Export Supervision of Hazardous Chemicals
    • Practical Guidance on Hazardous Chemical Classification and Identification
    • Policy Analysis and Corporate Response Strategies for the “One Enterprise, One Product, One Code” Initiative
    • Latest Developments in the Revision of “GB15258 – Specifications for the Preparation of Chemical Safety Labels”
    • Latest Global GHS Updates and China’s Response Recommendations
    • Interpretation of Safety Technical Requirements for Storage of Hazardous Chemical Reagent Warehouses

    Arrangements

    • Conference Date: March 11, 2026
    • Meeting Format: In-Person
    • Venue: Shanghai, China (Shanghai Hongta Hotel)
    • Languages: Chinese + Japanese Simultaneous Interpretation
    • Hosted by: China Warehousing and Distribution Association
    • Co-organizers: Association of International Chemical Manufacturers (AICM), Hangzhou REACH Technology Group Co., Ltd.
    • Organized by: Dangerous Goods Branch of China Warehousing and Distribution Association
    • Conference Fee: 980 RMB/person*

    *Members of China Warehousing and Distribution Association and AICM enjoy a 20% discount; other enterprises registering 3 or more participants receive a 20% discount. . Fee includes materials, refreshments, and lunch. Transportation and accommodation are self-arranged.

    This forum will feature

    • Core drafting experts of the Hazardous Chemicals Safety Law
    • Relevant officials from the General Administration of Customs and local customs authorities
    • Senior experts from the Shanghai Emergency Management Affairs and Chemical Registration Center
    • Senior executives from prominent chemical manufacturers and hazardous chemical storage enterprises
    • Chemical Registration Center of the Ministry of Emergency Management

    Agenda

    Time

    Agenda

    Invited Guests

    8:30–9:05

    Registration

     

    9:10–9:20

    Opening Remarks

    China Warehousing and Distribution Association, Hazardous Materials Branch

    International Chemical Manufacturers Association (AICM)

    Hangzhou REACH Technology Group Co., Ltd.

    9:20–10:00

    Interpretation of the Hazardous Chemicals Safety Law

    Ma Daqing, Principal Drafting Officer of the Hazardous Chemicals Safety Law

    China Academy of Work Safety

    10:00-10:30

    Interpretation of Customs Import/Export Supervision Trends

    Chen Xiang, Head of the Dangerous Goods Section

    Shanghai Customs Industrial Products and Raw Materials Testing Technology Center

    10:30–10:50

    Coffee Break

     

    11:00-11:30

    Technical Requirements for the Safe Storage of Hazardous Chemical Reagents

    Chen Jinhe, Associate Chief Physician

    Chemical Registration Center, Ministry of Emergency Management

    11:30-12:00

    Latest Updates on the Revision of GB15258 “Regulations for the Preparation of Chemical Safety Labels”

    Chen Jun, Senior Engineer

    Chemical Registration Center, Ministry of Emergency Management

    12:00–12:30

    Q&A

     

    12:30–13:40

    Lunch

     

    13:40 –14:20 

    Hazardous Chemical Classification and Identification of Hazardous Properties

    Yu Xin, Senior Engineer/Section Chief

    Shanghai Emergency Management Affairs and Chemical Registration Center

    14:20 –14:50 

    Latest “One Product, One Code” Policy for Chemicals and Response Recommendations

    Zhao Dongjiao, GHS Lead, Industrial Chemistry Technology Department

    CIRS Group

    14:50-15:10

    Coffee Break

     

    15:10-15:50

    Impact of the Hazardous Chemicals Safety Law on Chemical Storage

    Lin Zhenyu, Secretary-General

    Dangerous Goods Branch, China Warehousing and Distribution Association

    15:50-16:20

    Global GHS Regulatory Updates

    Qian Zhanpeng, Manager, Industrial Chemicals Division

    CIRS Group

    16:20 – 17:00

    Q&A

     

    Who Shall Attend

    • Members of the China Warehousing Association’s Hazardous Materials Branch, hazardous materials warehousing and logistics enterprises, and heads of chemical industrial parks nationwide
    • Member companies of the Association of International Chemical Manufacturers (AICM)
    • Heads of Logistics, Compliance, and Procurement Departments from Other Chemical Production, Import, and User Enterprises
    • Institutions involved in hazardous materials storage facility planning and construction, logistics program directors at various academic institutions
    • Suppliers of hazardous materials storage facilities and equipment (security, environmental protection, etc.)
    • Heads and safety supervisors of universities, laboratories, scientific research institutions, etc.

    Organizer

    China Warehousing and Distribution Association

    The China Warehousing and Distribution Association is a non-profit social organization registered with the Ministry of Civil Affairs in 1997, representing the national warehousing industry. It currently operates specialized branches including joint distribution, cold chain, hazardous materials, bonded warehousing, financial warehousing, traditional Chinese medicine warehousing, technology application and engineering services, self-storage, packaging and unitized logistics, smart logistics, home logistics, and parts logistics.The association’s mission is to advance the modernization of China’s warehousing and distribution sector and promote the development of modern logistics. Guided by the principle of “grounding in warehousing, refining services, focusing on priorities, and building brands,” it concentrates on developing various warehousing facilities, expanding distribution centers, and driving innovation in warehousing, distribution services, and technology.

    China Warehousing and Distribution Association Hazardous Materials Branch

    The China Warehousing and Distribution Association Dangerous Goods Branch (formerly the Dangerous Goods Warehousing Branch of the China Warehousing Association) was established in Beijing on May 9, 2008, with approval from the Ministry of Civil Affairs. It is the nation’s first specialized association dedicated to dangerous goods warehousing.Its membership comprises enterprises engaged in hazardous materials warehousing, transportation, production, operation, usage, and waste disposal, as well as research institutions, educational organizations, warehouse design firms, storage equipment manufacturers, and relevant experts and scholars. It served as the primary drafting unit for the “General Rules for Storage of Hazardous Chemicals in Warehouses” (GB15603-2022).

    Association of International Chemical Manufacturers (AICM)

    The Association of International Chemical Manufacturers (AICM) is an international organization dedicated to advancing sustainable development in the chemical industry. Its membership includes nearly 70 multinational chemical companies with significant investments in China. Through organizing events, publishing reports, and promoting university-industry collaboration, AICM focuses on areas such as the circular economy, green manufacturing, and laboratory safety to deepen chemical companies’ commitment to social responsibility and sustainable development.

    CIRS Group

    CIRS Group is a global professional product safety management service provider established in 2007. Headquartered in Hangzhou, it maintains branches in Ireland,the United States, the United Kingdom, South Korea, Japan, Shanghai, Beijing, and Nanjing. CIRS provides one-stop compliance solutions—ranging from regulatory consulting and laboratory testing to R&D support and data services—for chemical, cosmetic, food, medical device, disinfectant, agrochemical, and consumer goods enterprises, research institutions, and industry associations. CIRS helps companies achieve product compliance, accelerate market access, and enhance global competitiveness.

    Registration and Contact

    Scan the QR code below to register directly

    https://www.cirs-group.com/files/bjaxmp0rnwn4/content/2026/01/fat7urxbdse8.png

    Or add on WeChat by scanning the QR code to inquire about registration and conference details.

    https://www.cirs-group.com/files/bjaxmp0rnwn4/content/2026/01/fat7l1bggcn4.jpg

    Email: pgl@cirs-group.com

      

    We have launched a LinkedIn newsletter to keep you up to date on the latest developments across the chemical industry including food and FCMs and personal and home care.

    Continue Reading

  • Takaichi and the AI trade in focus this week

    Takaichi and the AI trade in focus this week

    Japan’s Prime Minister Sanae Takaichi, leader of the ruling Liberal Democratic Party (LDP), speaks during a press conference at the LDP headquarters in Tokyo, Japan, on February 9, 2026.

    Franck Robicho | Anadolu | Getty Images

    There's nearly nothing that apparently can't be deployed as a trading strategy. We have the "TACO" trade, the Fed put trade, the artificial intelligence trade and, now, capturing traders' attention is the "Takaichi trade" — fueled by Japan's Prime Minister Sanae Takaichi's landslide victory in Sunday's elections.

    The Takaichi trade is fueled by expectations that the prime minister's economic policies will boost equities, while weakening the yen as she prefers a looser monetary policy and higher government spending.

    Indeed, Japanese stocks hit a record high on Monday, and extended gains on Tuesday. "The strong LDP win is warming the hearts of investors," said Frederic Neumann, chief Asia economist at HSBC.

    U.S. markets also closed higher overnight. Big Tech stocks mostly rebounded, with Oracle jumping 9.6% and Microsoft advancing 3.1%. That helped the S&P 500 climb 0.47% and the tech-heavy Nasdaq Composite jump 0.9%. The Dow Jones Industrial Average ticked up 0.04% — but that still lifted it to another record close.

    Heavy capex and financing concerns still swirl around Big Tech, however. Alphabet warned in its annual financial report last week that it could be left with "excess capacity" of data centers in a less-than-ideal scenario.

    That said, the Google-parent is still planning to raise $20 billion from a U.S. dollar bond sale — with one bond having a 100-year tenor and denominated in sterling — according to people familiar with the matter, who asked to remain unnamed because the details are confidential.

    In other tech news, ChatGPT is "back to exceeding 10% monthly growth," according to CEO Sam Altman's memo to employees. If the broader industry can enjoy such expansion over the long term, Alphabet is unlikely to face any "excess capacity" issues.

    — CNBC's Lim Hui Jie and Jennifer Elias contributed to this report.

    What you need to know today

    And finally...

    Gold and silver price swings are powering algo traders and machine-learning funds

    As gold and silver prices continue to seesaw, one corner of the hedge-fund industry is mining an opportunity from the huge swings in precious metals.

    Commodity trading advisors, also known as trend-following or managed futures funds, are computer-driven investment strategies that trade investment trends across different futures markets, including equities, bonds, currencies, and commodities.

    — Hugh Leask


    Continue Reading

  • REGENXBIO’s MPS II Gene Therapy RGX-121 Hit With CRL | NeurologyLive

    REGENXBIO’s MPS II Gene Therapy RGX-121 Hit With CRL | NeurologyLive

    REGENXBIO’s biologics license application (BLA) for clemidsogene lanparvovec (RGX-121), an investigational adeno-associated virus (AAV) vector-based gene therapy intended to treat mucopolysaccharidosis type 2 (MPS II, also known as Hunter syndrome), has received a complete response letter (CRL) from the FDA.1

    According to REGENXBIO, the FDA’sCRL, which it received on February 7, 2026, covered several reasons that the gene therapy product was not approved—despite the agency’s agreement with the study protocol in principle—including concerns about the ability of the clinical trial eligibility criteria to distinguish between neuronopathic disease and attenuated disease adequately, whether the external natural history control population used is sufficiently comparable to the trial population, and if there is reasonable likelihood that the surrogate end point used—heparan sulfate (HS) D2S6 levels in the cerebrospinal fluid (CSF)—can predict clinical benefit in an appropriate manner. Notably, the CRL contained several suggested pathways to a potential approval for the product, such as a new clinical trial, carrying out dosing of additional patients with longer follow-up, and implementation of an untreated control group on-study. Although, REGENXBIO stated that it has concerns about the difficulty of these pathways considering the ultrarare nature of MPS II.

    “This decision is devastating for the families of boys living with this progressive, life-threatening disease,” Curran M. Simpson, the president and chief executive officer of REGENXBIO, said in a statement.1 “We are concerned about FDA’s feedback regarding the overall development path and evaluation of the data in the context of the urgent need for this irreversible ultra-rare disease. We remain confident in the quality and volume of evidence demonstrating the long-term potential of RGX-121 to positively change the trajectory of Hunter syndrome. This program has been in development for over 10 years. We are incredibly grateful to all the patients, their families, investigators, and site staff who have supported this program and our continued efforts to bring a much-needed new treatment option to the Hunter syndrome community. We will continue those efforts.”

    REGENXBIO stated its intent to pursue a Type A meeting with the FDA to discuss a planned resubmission of the BLA, which it noted could include longer-term clinical data and “additional evidence from global MPS II experts to further clarify the neuronopathic patient population.”1 The company noted that it believed it had already addressed the FDA’s concerns through data updates and responses to information requests during the BLA review period and that analyses and reviews had been held between the FDA and “leading global MPS and biomarker experts” during this period.1

    “MPS II is a very complex disease, but its impact is well established, resulting in irreversible brain damage for the majority of patients; without appropriate treatments stopping this neurocognitive decline, the neuronopathic MPS II child will die prematurely, usually in their mid-teens,” Joseph Muenzer, MD, PhD, the director of Muenzer MPS Research and Treatment Center and a Bryson Distinguished Professor in the Division of Genetics and Metabolism in the Department of Pediatrics Genetics at University of North Carolina at Chapel Hill, added to the statement.1 “I remain encouraged by the clinical data behind RGX-121. New innovations like gene therapy could make a significant impact for these patients, and time is precious for these families.”

    Notably, the pivotal phase 1/2/3 CAMPSIITE clinical trial (NCT03566043) evaluating RGX-121 was placed on clinical hold by the FDA in January 2026.2 The hold was related to an intraventricular central nervous system tumor that occurred in 1 patient who was treated with RGX-111, a separate REGENXBIO AAV vector-based gene therapy product under evaluation for severe mucopolysaccharidosis Type I (MPS I, also known as Hurler syndrome) in a phase 1/2 clinical trial. The patient has not experienced symptoms, but the neoplasm was identified on a routine brain MRI 4 years after the patient was treated with the gene therapy product, and preliminary analysis indicated an AAV vector genome integration event associated with overexpression of PLAG1, a protooncogene. REGENXBIO noted that the tumor was resected, that the patient has shown positive developmental advancements, and that whether the serious AE was related to RGX-111 has not yet been determined. Although the event occurred in an RGX-111 trial, according to the company the FDA placed a hold on the RGX-121 program in addition to the RGX-111 program because of “similarities in products, study populations, and shared risk between the clinical studies.”2

    “We are surprised by FDA’s decision to place our RGX-121 program on hold while the investigation of this single, inconclusive incident in RGX-111 continues,” Simpson said in a January 2026 statement.2 “These are separate therapies, and the positive safety profile of RGX-121 in more than 30 patients treated, including those dosed nearly 7 years ago, remains unchanged. Patient safety is our top priority, and we, our investigators, and the patient community remain confident in the benefit-risk ratio of RGX-121 and are highly encouraged by the meaningful efficacy profile demonstrated in the pivotal trial. RGX-121 presents an opportunity to address the urgent, significant unmet medical need in this ultrarare disease community, and continued delay means continued neurodevelopmental decline in boys with MPS II.”

    REFERENCES
    1. REGENXBIO announces regulatory update on RGX-121 BLA for MPS II. News release. REGENXBIO Inc. February 9, 2026. Accessed February 9, 2026. https://ir.regenxbio.com/news-releases/news-release-details/regenxbio-presents-positive-twelve-month-pivotal-data-phase
    2. REGENXBIO announces regulatory update on ultra rare MPS programs. News release. REGENXBIO Inc. January 28, 2026. Accessed January 28, 2026. https://ir.regenxbio.com/news-releases/news-release-details/regenxbio-announces-regulatory-update-ultra-rare-mps-programs/

    Continue Reading