Category: 3. Business

  • Department of Labor & Workforce Development

    December 23, 2025 

    TRENTONAs the Murphy Administration celebrates eight years of progress, the New Jersey Department of Labor and Workforce Development (NJDOL) is highlighting the major advancements made since 2018 to strengthen worker protections, expand benefits, modernize critical systems, and prepare New Jersey’s workforce for the jobs of the future. Backed by landmark bipartisan legislation, rigorous enforcement, and significant investments in training and career services, New Jersey has emerged as a national leader in worker support and customer-centered innovation. 

    During this period, a record 120 new laws were added to NJDOL’s purview, expanding its abilities to protect New Jersey’s workforce, strengthen businesses, and promote the dignity of work. 

    “Over the past eight years, we have worked closely with the Department of Labor and Workforce Development to deliver historic advancements for New Jersey workers,” said Governor Murphy. “Through landmark legislation and major investments, we have strengthened worker protections, expanded benefits including paid sick and family leave, and enhanced workforce development opportunities. These efforts have been essential to building a stronger economy while ensuring fair treatment and equal pay for New Jersey workers. In the face of unprecedented challenges during the pandemic, the labor systems we have modernized reflect our commitment to supporting the working families and labor unions who make our state strong.”

    “Even as we triaged historic levels of unemployment claims during a once-in-a-century pandemic, our department never stopped pushing forward. We modernized our systems, expanded worker protections, improved customer service, and built lasting capacity that will benefit New Jersey for decades,” said Labor Commissioner Robert Asaro-Angelo. “Delivering record benefits was a milestone, but so was everything we achieved alongside it. And the teams at this labor department are not done yet. This mission isn’t about the work of one administration but rather maintaining progress so our workers and employers have the strong, reliable support they deserve.”  

    Expanding Worker Protections and Benefits  

    New Jersey has enacted some of the strongest, bipartisan worker protection laws in the country. This includes statewide earned sick leave, an expanded suite of Temporary Disability and Family Leave benefits, and significant increases in the minimum wage. Workers now have greater access to enhanced wage-replacement rates; and more flexible paid leave options to care for themselves or their families without sacrificing their livelihood. Additionally, New Jersey’s minimum wage rate will increase to $15.92 in January 2026, which not only raises workers’ income, but typically reduces poverty and stimulates the economy through increased spending. 

    Strengthening Enforcement and Combating Worker Misclassification  

    The Administration has prioritized fair treatment for workers and accountability for employers. NJDOL has implemented a gold-standard enforcement strategy to eliminate wage theft, protect legally earned benefits, and prevent the misclassification of employees as independent contractors. NJDOL created new oversight units, issued over 200 stop-work orders across multiple industries, and secured major settlements that returned tens of millions of dollars to workers. These actions hold violators accountable while ensuring a level playing field for responsible employers.  

    As a result, NJDOL’s Divisions of Wage and Hour Compliance and Employer Accounts have helped put $100 million back into the pockets of workers.  

    Modernizing Unemployment and Improving the Customer Experience  

    Building on improvement efforts spotlighted during the COVID-19 pandemic, when the state delivered nearly $40 billion in unemployment benefits, NJDOL has continued modernizing its Unemployment Insurance system. Recent upgrades include a redesigned application portal, improved communication tools, and a more responsive call-center platform. With the Unemployment Insurance Trust Fund restored to its strongest level in more than two decades, the state has also reduced UI tax burdens for employers.  

    In May 2024, NJDOL launched a completely rebuilt online UI application. The new version uses simplified language, conditional logic, and fewer questions. According to users, it is also now easier to complete on mobile devices, tablets, or desktops. These improvements alone have dramatically reduced the time needed to complete the application — saving applicants as much as 45 to 47 minutes compared to the legacy system. A modern, cloud-based phone system was also implemented in 2024 reducing callback times from up to an hour to around 90 seconds, drastically improving customer service for those who still need to speak with UI agents.  

    Protecting New Jerseyans Through Fraud Prevention  

     As part of modernization, NJDOL deployed a new UI fraud-prevention solution. Recognized by the National Association of State Workforce Agencies (NASWA) with the 2025 Merrill Baumgardner Innovation in Information Technology Award, the system leverages advanced analytics to detect and mitigate fraudulent claims while protecting public funds.  

    Investing in Workforce Development and Apprenticeship Growth  

    New Jersey has increased apprenticeship programs in the state by 155 percent over the previous administration through $100 million in investments. DOL-recognized programs have been expanded into a wide variety of occupations such as construction, early childhood education, registered nursing, pharmacy technicians, stagehands, water treatment plant operators, fiber optic technicians, and more. This funding has also helped onboard nearly 23,000 new apprentices. The state currently has approximately 9,500 active apprentices in about 1,460 programs.  

    Meeting New Jersey Workers Where They Are 

    The Department has expanded access to its services and strengthened community outreach through several key initiatives. Career services are now offered in person, virtually, and by phone, ensuring jobseekers can get support in whatever way works best for them. New tools like SkillUp NJ, providing free online training, and My Career NJ, an AI-powered platform offering personalized recommendations on jobs, training, and career transitions, make it easier for residents to navigate today’s labor market.  

    Through the Office of Strategic Outreach and Partnerships, the Department is also engaging employer organizations, worker advocates, and community groups to broaden awareness of workplace rights and responsibilities. NJDOL’s Cultivating Access, Rights, and Equity (CARE) program grantees have already connected with more than a quarter million workers and employers, extending vital information to communities that need it most.  

    Protecting Vulnerable Workers Through New Authorities 

    NJDOL established protections for temporary and domestic workers to address their vulnerability to exploitation. Temporary worker protections ensure fair treatment, including transparent employment terms, equitable wages, and safe conditions. Domestic worker protections safeguard the rights of those in private households, focusing on fair compensation, reasonable hours, and a respectful work environment. These measures underscore New Jersey’s commitment to worker rights and the unique needs of these often underrepresented labor groups. 

    Partnering with New Jersey’s Industry Leaders 

    Launched in the early days of the Murphy Administration, New Jersey’s Industry Partnerships program is a business-led, sector-focused initiative run that brings together employers, educators, workforce and economic-development partners to collaboratively address industry needs and strengthen regional economies. Organized by key sectors such as manufacturing, health care, energy, life sciences, and transportation, the partnerships rely on industry leaders to identify workforce challenges and priorities, while public partners align training, education, and resources to support those needs. This results in a responsive talent pipeline, improved coordination across agencies, and relevant training and career pathways to help New Jersey industries remain competitive.  

    Bridging Opportunity Gaps 

    Throughout the Murphy Administration, NJDOL awarded more than $19 million in New Jersey Builder’s Utilization Initiative for Labor Diversity (NJBUILD) funding to support the training of approximately 1,559 women, minorities, and veterans in the construction trades. This is a part of a larger effort that seeks to eliminate economic barriers commonly associated with investing in skills training and work readiness and connect minority populations and women to quality career and training opportunities in the building and construction industry. 

    The Growing Apprenticeship in Nontraditional Sectors (GAINS) grant program has provided unprecedented opportunities for women and people of color, with more than two-thirds of participants being women or minorities – twice the average among all apprenticeship programs in the state. Women account for 67 percent of GAINS apprentices, greater than seven times the statewide average of female apprentices when Governor Murphy took office in January 2018. The GAINS program has doubled the number of women in Registered Apprenticeships throughout the state.  

    Advancing Prosperity, Jobs, and Opportunity   

    These efforts represent a portion of the state’s expansive worker-focused agenda that reflects its commitment to building a future in which every New Jerseyan can earn competitive wages, feel safe and protected when providing for their families, and find meaningful opportunities for professional growth through the Garden State.  

    For more information about the mission of the Department, visit:  

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  • City of Palm Coast Hosts Final Community Engagement Session for Prosperity 2035 Vision Plan

    City of Palm Coast Hosts Final Community Engagement Session for Prosperity 2035 Vision Plan

    The City of Palm Coast invites residents, business owners, and community leaders to attend the final community engagement session for the Community-Driven Economic Development Vision Plan, Prosperity 2035, on Thursday, January 15, from 6–8 p.m. at the Palm Coast Community Center, 305 Palm Coast Parkway NE. The meeting is free and open to the public.

    This final session will give the community an opportunity to learn what was heard throughout the engagement process led by the Northeast Florida Regional Council (NEFRC). Attendees will hear a summary of key themes, priorities, and feedback gathered from residents and stakeholders, and will have the opportunity to provide final input before the plan is finalized.

    Residents are also reminded that the Prosperity 2035 Community Survey remains open through January 15. The survey is a critical part of the process and provides an easy way for community members to share their priorities, even if they are unable to attend the meeting in person. The survey can be accessed at https://www.menti.com/alczumkgrbdq.

    Following the conclusion of the engagement process, the final Prosperity 2035 results and recommendations will be presented to the Palm Coast City Council in April 2026, helping guide future economic development decisions and initiatives.

    The Prosperity 2035 initiative is focused on strengthening Palm Coast’s economic future while preserving the quality of life that makes the city a great place to live, work, and do business.

    For more information, email palmcoastvision@nefrc.org or visit palmcoast.gov/events/home/details/prosperity-2035.

    Stay informed with the latest news and information from the City of Palm Coast by following us on FacebookInstagramTwitterYouTube, and LinkedIn. You can sign up for weekly updates by visiting www.palmcoastgov.com/government/city-manager/week-in-review


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  • Fannie and Freddie Empowered to Support Middle-Class Homeownership

    Fannie and Freddie Empowered to Support Middle-Class Homeownership

    Washington, D.C. – Today U.S. Federal Housing issued a final rule that establishes new, better affordable housing goals for Fannie Mae and Freddie Mac. Thanks to this fix, Fannie and Freddie will continue to fully support mortgages for families from every walk of life. 

    “For too long, Biden distorted the housing market with harmful mandates that prioritized government quotas at the expense of middle-class families,” said Director William J. Pulte. “Thanks to President Trump, Fannie Mae and Freddie Mac will now focus on supporting affordable homeownership for all Americans while fulfilling their statutory duties.”

    The 2026–2028 Enterprise Housing Goals final rule can be found here.

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    The Federal Housing Finance Agency regulates Fannie Mae, Freddie Mac, and the 11 Federal Home Loan Banks. These government-sponsored enterprises provide more than $8.5 trillion in funding for the U.S. mortgage markets and financial institutions. Additional information is available at www.FHFA.gov, on X @FHFA, YouTube, Facebook, and LinkedIn.

     

    Contact: MediaInq​uiries@FHFA.gov

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  • DLR and LDA Welcome Planning Approval for Dundrum Central Development Delivering 934 Homes

    A key element of Dundrum Central will be the associated services and facilities being delivered, including a community centre with a multipurpose sports facility, a medical centre, retail units, a café, a crèche and a new public plaza. 

    In May 2023, a separate permission was granted by An Bord Pleanála for 852 affordable homes, however, the development has not proceeded due to a legal challenge, which is being defended by the LDA.  Responding to concerns that were raised during the initial consultation phase, the approved scheme includes reduced apartment building heights, now ranging from 2-8 stories. When realised, Dundrum Central will create a well-serviced new community in a prime location in South Dublin, which will be sustainably integrated into the surrounding locality. 

    Reacting to the decision, John Coleman, CEO of the Land Development Agency said:

    ‘The LDA welcomes the decision from An Coimisún Pleanála to approve this planning application at Dundrum Central. This is an important milestone for a long-awaited project, which is vital to delivering much needed affordable housing in an area with a significant unmet need.   Having engaged with the community since project inception, we understand how necessary this project is. We are eager to progress the project and deliver on our commitments to current and future residents through our partnership with Dún Laoghaire- Rathdown County Council.’

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  • Fighting Forward: A New Strategic Plan for Georgia Workers and Businesses

    Fighting Forward: A New Strategic Plan for Georgia Workers and Businesses

    By Georgia Labor Commissioner Bárbara Rivera Holmes

    My grandfather used to say, “Luchando Pa’lante” — fighting forward. Those words carried my family from Cuba to America and shaped everything I believe about opportunity in this country and in this state. Since stepping into this role earlier this year, I’ve come to see that fighting forward is not only a family motto; it’s also a Georgia value. It’s the grit of workers who show up before sunrise, the resilience of small businesses that anchor our communities, and the determination of every Georgian striving for a better future.

    That spirit of resilience shaped our bold, comprehensive plan to transform how the Georgia Department of Labor (GDOL) serves every Georgian. When Gov. Brian Kemp appointed me Labor Commissioner earlier this year, I didn’t begin with speeches. I started behind the wheel, driving across the state — to manufacturing floors, career centers, farms, small businesses, and boardrooms — listening directly to the people who power Georgia’s economy.

    Parents told me about waiting weeks for unemployment checks. Employers shared how hard it is to find skilled workers quickly enough to meet demand. Community leaders talked about workforce potential that goes untapped because the systems supporting it are outdated or too difficult to navigate.

    Those conversations inspired every initiative in our plan — from how we deliver unemployment benefits to how we connect talent and employers. In Fall 2026, we’ll launch the largest unemployment insurance modernization in Georgia’s history. The agency will replace its outdated platform with a secure, cloud-based system designed to improve user experience, reduce fraud, and accelerate claims processing. This upgrade tackles long standing challenges — from call center delays to digital access barriers — that have slowed workers and employers alike.

    The system we’re replacing was built in the 1980s — back when Ataris were popular, payphones were everywhere, and Journey’s “Don’t Stop Believin” topped the Billboard charts. It served its time, but it’s slow, clunky, and out of step with today’s needs. With this modernization, claims will process faster, fraud prevention will be stronger, and workers and employers will have a more reliable, responsive system.

    But this plan is not just about technology; it’s about people. That’s why we’re rewriting every communication in plain language, making our processes easier to navigate, and removing red tape so Georgians can get the help they need.

    This transformation runs on partnership. We’re expanding our job matching infrastructure and strengthening relationships with employers, educators, workforce boards, and community leaders to build a talent pipeline that meets the needs of the moment — connecting Georgians to mortgage paying jobs and businesses to the skilled workers they need. At the same time, we’re enhancing digital access, improving call center responsiveness, and cultivating a more agile, service oriented agency.

    This work matters because Georgia’s economy is evolving faster than ever. Automation, artificial intelligence, and advanced manufacturing are reshaping the jobs of tomorrow. A modern labor system is no longer a convenience; it is a competitive advantage. If we want Georgia to remain the No. 1 state for business, we must build systems that match that ambition.

    When I return home to Albany after traveling across the state or working out of our Atlanta office, I’m greeted by my family, our dogs, and our backyard flock of hens. Coming home grounds me and fuels my commitment to this work. That commitment extends to families across Georgia, who are counting on us to deliver clarity in communication, consistency in service, and opportunity for growth. They deserve a department that meets the urgency and integrity they bring to their work every day.

    Georgia leads by embracing what’s next — and, in many cases, by creating it. This plan carries that tradition forward not with small tweaks, but with a full reimagining of how government serves its people and a path to making Georgia the nation’s top state for talent.

    We are building an agency that fights forward — with modern systems, clearer communication, stronger partnerships, and a renewed commitment to public service.

    Our work is a journey, and like the classic rock anthem that played when our legacy system was built, we remind all Georgians: Don’t stop believing. With workers and businesses leading the way, Georgia’s best days are ahead.

    Let’s move forward — juntos, together.

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  • Minutes of the Meeting of the Court of Directors held on 28 October 2025

    Minutes of the Meeting of the Court of Directors held on 28 October 2025

    Present Committee members:

    David Roberts, Chair
    Andrew Bailey, Governor
    Sarah Breeden, Deputy Governor – Financial Stability
    Clare Lombardelli, Deputy Governor – Monetary Policy
    Sir Dave Ramsden, Deputy Governor – Markets & Banking
    Sam Woods, Deputy Governor – Prudential Regulation (until item 11)
    Jonathan Bewes
    Sabine Chalmers
    Lord Jitesh Gadhia
    Dame Anne Glover
    Sir Ron Kalifa
    Diana Noble
    Tom Shropshire

    In attendance:

    Sarah John, Chief Operating Officer (until item 10)

    Secretary:

    Sebastian Walsh, Secretary of the Bank

    1. Conflicts, Minutes and Matters Arising

    There were no conflicts declared in relation to the present agenda.

    The minutes of the meeting held on 19 September were approved.

    The Chair noted this would be Ron Kalifa’s last Court meeting, and on behalf of the Bank, thanked him for his service.

    2. Governor’s Update

    The Governor updated Court on the Bank’s business and workforce planning, noting the two critical aspects were now to engage the Bank’s broader leadership on the programme and to ensure the Bank had the capacity to deliver planned changes.

    The Governor informed Court that following Court’s approval of the changes to the Bank’s FX balance sheet, the Bank had successfully issued an additional dollar bond.

    Court heard that the Bank would launch the consultation on the stablecoins regime on 10 November. Dave Ramsden noted the Bank had engaged with other authorities to discuss how the regime could impact them.

    The Governor updated Court on the results of the public consultation on the design of the next series of banknotes.

    3. Audit and Risk Committee (ARCo) Update

    Jonathan Bewes gave an update on the recent meeting of ARCo. In the Audit meeting, ARCo heard from the external auditors, Ernst & Young, on the planning for next year’s audit and had a discussion on how the workforce planning programmes would be accounted for. ARCo also received an update from Internal Audit on recently completed audits.

    In the Risk meeting, ARCo received an update on decisions regarding the investment portfolio, as well as the revised Risk directorate strategy and its implementation. ARCo reviewed the new cyber-security dashboard and had an update on access management metrics. Directors noted the increase in cyber-attacks by state actors in other jurisdictions and the importance of the Bank remaining vigilant.

    The Chair asked that an assessment of cyber-risk come to Court.

    4. Remuneration Committee (RemCo) Update

    Diana Noble gave an update on the recent meeting of RemCo. RemCo approved the creation of a Mutually Agreed Resignation (MAR) Scheme and the terms of the scheme. RemCo discussed the actions needed to ensure effective engagement with staff around the scheme. RemCo also emphasised the importance of ensuring the scheme was used to deliver sustainable cost savings.

    Directors confirmed support for the proposals.

    5. COO Update

    Sarah John updated Court on the Bank’s annual salary review and negotiations with the Union on the offer and said that the Union had recommended the Bank’s offer to staff. She added that progress had been made on the SharePoint migration, and the first new and improved laptops had been rolled out.

    In response to questions, Sarah John said the Bank remained committed to reaching 500 staff in Leeds. She added that Governors had agreed that, to further progress towards this target, Executive Directors would be required to recruit 50% of any external recruitment to the Leeds office.

    • Finance Modernisation Project (FMP) Update

    Court approved a revised budget for FMP.

    6. 2025/2026 Q2 Financial Forecast

    (Afua Kyei)

    Court congratulated Afua Kyei on being voted the most influential person of African or African Caribbean heritage in the United Kingdom in the 2026 Powerlist.

    Afua Kyei gave an update on the current financial position, noting an underspend is expected in 25/26 due to areas making a start on meeting the 8% cost challenge in 26/27. This underspend would be used to support workforce planning programmes.

    In response to questions from Directors, it was confirmed that the Bank would still seek to meet the 8% cost challenge target in year and would consider how plans could be revised to deliver this.

    7. Business Planning 2026/27 Update

    (Jo Hill, Afua Kyei and Louise Buckley)

    Jo Hill introduced the paper noting that with the Bank’s strategic goals having been set, these were now the necessary steps to deliver them.

    Directors raised the importance of embedding transformation and productivity in the Bank’s culture. Directors noted that the 8% target was applied equally across the Bank.

    The Chair noted the importance of delivering the benefits of the transformation programmes to staff, including better technology, to show the positive impact of the Bank changing. Court approved the plans.

    8. Location Strategy Project (LSP) – Strategic Business Case

    (Vivienne Grafton and Tom Horn)

    Vivienne Grafton introduced the paper, noting this was a once in a generation opportunity to improve both the Bank’s premises and its geographical reach. Vivienne Grafton noted that the cost savings from exiting Moorgate meant the project had a positive net present value with a capacity to absorb potential cost overruns, which was important as some risks to projected costs were to be expected when working on a historic building.

    Directors discussed the importance of value for money and ensuring the Bank maintained the building appropriately, which was of substantial historical interest and a national asset. Directors noted there was a reputational risk around the rebuild and that the robustness of the business case and communications were critical.

    Directors discussed the effective limit on London based headcount the programme would create for the future. They noted that, in the event the Bank needed to grow in future, this could be accommodated by growing headcount in Leeds.

    Directors asked that the project consider the case for independent expert challenge on the project, noting it was outside of the Bank’s usual responsibilities.

    9. Six-Monthly Risk Report

    (Jonathan Rand)

    Jon Rand introduced the Risk report and said that the Bank’s important business services remain resilient, although some of the more obsolete systems the Bank continues to need to run require continual maintenance. Jon Rand said that reviews of cyber-risk in the supply chain had been positive but that supply chain risk, especially for cyber, was an area of heightened concern due to external events.

    Directors discussed the heightened people, operational and delivery risks coming from running major operational change programmes and workforce change programmes concurrently. Jon Rand said that Risk would seek to identify leading indicators for risks crystallising through workforce changes and that business areas would seek to identify single points of failure.

    10. Banknote Innovation Programme

    (Victoria Cleland and Jennifer Small)

    Victoria Cleland introduced the paper, explaining that the programme to deliver the next series of banknotes compromised three strands: the printing contract, the design of the next series of notes and property adaptations at Debden to support continued printing.

    Cout discussed the continued demand for banknotes and the continued risk from counterfeiting. In response to questions on the pace of innovation in counterfeiting, Victoria Cleland and Jen Small outlined the current innovations in banknote security features and forward planning to prevent counterfeits.

    Court approved the paper and budget. Court delegated authority to the COO and Governor to approve a contingency of up to an additional 10% and to the Chair of Court and the Governor for a further 5% (up to 15% in total).

    11. Chair’s Monetary Policy Committee (MPC) effectiveness review 2025

    Court discussed the effectiveness review, noting the contributions and debates of the MPC surrounding the changes to the forecast process following the Bernanke Review.

    12. Support for Monetary Policy: Annual Report to Court 2024/2025

    (Iain de Weymarn and Fergal Shortall)

    Court noted the report.

    13. SMD Auction and Bilateral Trading Review (SABR) Programme

    Court approved the Programme. Court agreed that a 10% contingency, if required, could be released upon agreement by the COO and the Governor.

    14. Revised ‘Our Code’ Conflicts of Interest Policies and Statutory Committees’, Conflicts of Interest Codes of Practice

    Court approved the policies and Codes of Practice.

    15. FPC Members External Communications Code

    Court approved the Code.

    16. Committee Appointments and Conflicts update

    Court noted the report.

    17. Papers for Information

    Court noted:

    • Monetary Policy Committee Report
    • Approved minutes from Committee meetings since the last meeting of Court on 19 September 2025
      • ARCo minutes 24 June 2025

    The meeting of Court was closed.

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  • NINDS Preclinical Common Data Elements/Data Standards Webinar Series

    NINDS Preclinical Common Data Elements/Data Standards Webinar Series

    Image

    The National Institute of Neurological Disorders and Stroke (NINDS) is pleased to invite you to the Preclinical Common Data Elements (CDE)/Data Standards Webinar Series Kick-off on January 28, 2026.  This monthly webinar series is designed to be interactive and to engage researchers and stakeholders with up-to-date information on preclinical common data elements (CDEs) and data standards. Webinars will address a breadth of topics related to preclinical research such as experimental design, rigor, reproducibility, metadata, data repositories, injury models, EEG& seizures, biomarkers, -omics, histopathology and imaging and best practices for data sharing. Working group members from the Neurotrauma Preclinical Common Data Elements (CDE) & Data Standards (NT-PRECEDS) Program will present the preclinical CDEs that are being developed. Invited speakers will share best practices for data standardization and highlight resources to streamline and harmonize preclinical research datasets. The webinar aims to showcase essential tools that support data harmonization, facilitate data sharing and robust cross-study analyses by promoting the FAIR and TRUST data sharing principles and aligning with NIH strategic plan and Data sharing policy.

     

    These webinars are open to the public. Everyone is welcome to attend.

    Register here to receive the webinar invitations and recordings.

    For additional information, visit the NT-PRECEDS program webpage. 

    For questions, contact Claudio Villalobos-Dintrans

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  • Trained Immunity: RoadMap for drug discovery and development

    Trained Immunity: RoadMap for drug discovery and development

    1 NCT ID NCT06257212 Title Live Vaccines and Innate Immunity Training in COPD Dates 2024/02/28 to 2025/09 Phase Phase 4 Enrolment 60 (Estimated) Condition(s) COPD Intervention(s) BCG vaccine
    MMR vaccine Primary Outcome Innate immune training measured by fold-changes in cytokine production capacity of innate immune cells following pro-inflammatory stimulation. Measured from inclusion in the trial to 4 months’ post-inclusion. Cytokines include: IL-1β, IL-10, TNF-α, IFN-γ 2 NCT ID NCT06266754 Title The Non-Specific Immunological Effects of Providing Oral Polio Vaccine to Seniors in Guinea-Bissau Dates 2024/01/29 to 2024/12/31 Phase Phase 4 Enrolment 80 (Estimated) Condition(s) Vaccine Reaction Intervention(s) Oral Polio vaccine Primary Outcome
    1. Levels of proinflammatory cytokines (including IL1-β, TNF-α, IFN-γ) after stimulation of PBMCs with non-OPV antigens and mitogens 1 month after intervention

    2. Levels of plasma markers of systemic inflammation (e.g. TWEAK and SIRT2) 1 month after intervention

    3. Investigating epigenetic changes in PBMCs by single-cell ATAC-sequencing and whole-genome methylation assays 1 month after intervention

    4. Investigate transcriptional effects on immune cells by single-cell RNA-sequencing 1 month after intervention. Identifying proportions of immune cell subsets

    3 NCT ID NCT05208060 Title Study to Evaluate the Ability of Sublingual MV130 to Induce the Expression of Trained Immunity in Peripheral Blood Cells Dates 2023/09/01 to 2025/12/31 Phase Phases 1 and 2 Enrolment 48 (Estimated) Condition(s) Immune Response Intervention(s) MV130 vaccine Primary Outcome Increase in ex vivo PBMCs cytokine response (TNF-α, IL-6, IL-1β) to secondary restimulation compared to placebo at days 15, 45, and 70 with respect to baseline Selected Secondary Outcomes relevant to Trained Immunity
    1. Epigenetic and metabolic changes in purified monocytes from PBMCs, including specific Trained Immunity-associated miRNAs (miR155, miR146, miR21), lactate production, glucose consumption, and mitochondrial activity at day 45 with respect to baseline

    2. Change in proportions of immune cells (including T cells, B cells, NK cells, and subsets of monocytes) in peripheral blood at days 15, 45, and 70 with respect to baseline

    4 NCT ID NCT02403505 Title Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer Dates 2021/12/28 to 2025/02/28 Phase Phase 1 Enrolment 20 (Estimated) Condition(s) Rectal Cancer Intervention(s) CEA protein antigen and BCG vaccine mix for percutaneous use Primary Outcome Timeframe: up to 90 days

    1. Participants with positive CEA blood test

    2. Participants with positive IGRA blood test with CEA protein antigen after percutaneous use

    3. Participants with IGRA blood test with TB antigens (negative before percutaneous use, positive after percutaneous use)

    5 NCT ID NCT05507671 Title The Role of BCG Vaccine in the Clinical Evolution of COVID-19 and in the Efficacy of Anti-SARS-CoV-2 Vaccines Dates 2021/05/27 to 2023/12/31 Phase Phase 3 Enrolment 556 (Estimated) Condition(s) COVID-19 Intervention(s) BCG vaccine Primary Outcome
    1. Incidence of SARS-CoV-2 infection. Timeframe: 6 months from recruitment day

    2. Incidence of COVID-19 symptoms. Timeframe: 6 months from recruitment day

    3. Intensity of efficacy of first dose of vaccine against COVID-19. Timeframe: 6 months from recruitment day

    4. Duration of efficacy of the second vaccine dose against COVID-19. Timeframe: 1 year from recruitment day

    Selected Secondary Outcomes relevant to Trained Immunity Serum concentrations of cytokines TNF-α, IFN-γ, IL-1β, IL-4, IL-6, and IL-10 in 50 participants of BCG group versus 50 participants of placebo group 2 months after recruitment 6 NCT ID NCT06628544 Title Trained Immunity in Fungal Infection and Its Mechanism Dates 2020/09/01 to 2023/12/01 Phase Early Phase 1 Enrolment 79 (Actual) Condition(s) BCG vaccination Intervention(s) BCG vaccine
    Metformin Primary Outcome IL-6 and TNF-α cytokine production by PBMCs isolated after 5 days of continuous medication and restimulated with C. albicans or Mycobacterium tuberculosis 7 NCT ID NCT03296423 Title Bacillus Calmette-Guérin Vaccination to Prevent Infections of the Elderly Dates 2017/09/21 to 2020/11/30 Phase Phase 4 Enrollment 200 (Actual) Condition(s) Infection
    Hospitalization
    Mortality Intervention(s) BCG vaccine Primary Outcome Time to first infection. Timeframe: 12 months Selected Secondary Outcomes relevant to Trained Immunity
    1. Cytokine stimulation from PBMCs. Timeframe: month 3

    2. Epigenetic changes of circulating monocytes. Timeframe: month 3

    8 NCT ID NCT02114255 Title Effects of BCG on Influenza Induced Immune Response Dates 2014/05 to 2014/09 Phase Phases 2 and 3 Enrolment 40 (Actual) Condition(s) Influenza virus infection
    Trained Immunity Intervention(s) BCG vaccine Primary Outcome
    1. Difference in influenza antibody titers at days 14, 21, 28, and 42

    2. Difference in thrombocyte function at days 0, 14, 21, 28, and 42

    Selected Secondary Outcomes relevant to Trained Immunity
    1. IFN-γ, IL-10, type 1 IFN, IL-17, IL-22 production by ex vivo leukocytes stimulated with inactivated/live influenza virus at days 0, 14, 28, and 42

    2. Production of inflammatory mediators (including TNFα, IL-1β, IFN-γ, IL-10, IL-17, and IL-22) by ex vivo leukocytes stimulated with different stimuli (including M. tuberculosis, S. aureus, C. albicans, and inactivated influenza) at days 0, 21, 28, and 42

    3. qPCR/microarray of inflammatory transcriptional pathways at days 0, 14, 21, 28, and 42.

    4. Granzyme B production by ex vivo leukocytes stimulated with inactivated/live influenza virus at days 0, 14, 21, 28, and 42

    9 NCT ID NCT01734811 Title Efficacy and Safety Evaluation in Recurrent Wheezing Attacks (MV130) Dates 2012/10 to 2017/02 Phase Phase 3 Enrolment 120 (Actual) Condition(s) Bronchospasm
    Bronchiolitis
    Bronchitis Intervention(s) MV130 vaccine Primary Outcome Number of Recurrent Bronchospasm (Wheezing Attacks) (b) Trials investigating modulation of Trained Immunity for therapeutic benefit 10 NCT ID NCT06624436 Title Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dates 2024/10/24 to 2025/12 Phase Phase 4 Enrolment 52 (Estimated) Condition(s) Sepsis
    Neuroinflammatory Response
    Immunosuppression
    Endotoxemia Intervention(s) Dexamethasone
    Tocilizumab
    Anakinra Primary Outcome
    1. Plasma TNF concentrations upon second LPS challenge

    2. Cerebrospinal fluid TNF concentrations during repeated experimental human endotoxemia

    Selected Secondary Outcomes relevant to Trained Immunity
    1. Plasma cytokine (IL1RA, IL-6, IL-8, IL-10, MIP-1α, MIP-1β, MCP-1, G-CSF, IP-10, CX3CL1, YKL-40) concentrations (plasma and cerebrospinal fluid), other inflammatory protein biomarkers (Olink Target 96 inflammation panel) (plasma and cerebrospinal fluid), and mHLA-DR during first and second LPS challenges

    2. Blood leukocyte single-cell and bulk mRNA profiles/transcriptomic pathways upon LPS challenges

    3. Cytokine production of ex vivo leukocyte cultures

    11 NCT ID NCT03332225 Title A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis Dates 2017/12/15 to 2019/12/31 Phase Phase 2 Enrolment 36 (Actual) Condition(s) Sepsis
    Macrophage Activation Syndrome Intervention(s) Anakinra
    Recombinant human IFN-γ Primary Outcome Mortality. Timeframe: 28 days Selected Secondary Outcomes relevant to Trained Immunity
    1. Cytokine stimulation from PBMCs. Timeframe: 4 and 7 days

    2. Gene expression of PBMCs. Timeframe: 7 days

    3. Epigenetic changes of circulating monocytes. Timeframe: 7 days

    (c) Trials investigating inhibition of Trained Immunity for therapeutic benefit 12 NCT ID NCT05790499 Title LDL-c Level Variability and Trained Immunity Dates 2023/03/20 to 2024/01/31 Phase N/A Enrollment 12 (Estimated) Condition(s) Cholesterol Variability
    Trained Immunity Intervention(s) Atorvastatin Primary Outcome Changes in LDL-C levels between baseline and atorvastatin treatment cycles. Timeframe: 16 weeks Selected Secondary Outcomes relevant to Trained Immunity Timeframe: 16 weeks

    1. PBMCs subgroup percentage and activation status

    2. PBMCs secreting cytokines

    3. PBMCs change in gene expression

    4. Levels of hs-CRP, IL-6, IL-18, and sVCAM-1

    13 NCT ID NCT05210725 Title Trained Immunity by Dual-pathway Inhibition in Coronary Artery Disease Dates 2022/03/01 to 2022/07/01 Phase Phase 4 Enrolment 20 (Actual) Condition(s) Coronary Artery Disease Intervention(s) Rivaroxaban and Acetylsalicylic acid Primary Outcome Whole blood immune responsiveness to LPS stimulation when switching from acetylsalicylic acid monotherapy to acetylsalicylic acid and low-dose rivaroxaban dual pathway inhibition. Timeframe: 12 weeks Selected trial outcomes relevant to Trained Immunity
    1. White blood cell count and distribution. Timeframe: 3 months

    2. Monocyte immune responsiveness to LPS stimulation. Timeframe: 3 months

    3. Enrichment of epigenetic gene marks. Timeframe: 3 months

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  • CFS Aero Opens New State-of-the-Art APU Test Cell in Warwick

    Published: Tuesday, 23rd December 2025

    CFS Aero, a leading independent aerospace engineering company, officially opened its new Auxiliary Power Unit (APU) Test Cell on Wednesday 10 December.

    With an opening ceremony conducted by Cllr Naveen Tangri, Chairman of Warwick District Council.

    CFS Aero, which relocated to Warwick after its former site at Coventry Airport was earmarked for demolition, has become a valued part of the district’s growing high-technology and engineering community. The company expressed its gratitude to Warwick District Council for the practical support and guidance it provided during the relocation process, which helped secure skilled jobs and technical capability for the region.

    The new APU Test Cell represents a major investment in the company’s future and in Warwick’s reputation for advanced engineering. It features the latest digital monitoring systems, allowing engineers to view live performance data and conduct remote test observations from anywhere in the world. Its design also promotes efficiency and cleanliness, with a modern “plug-and-play” setup that allows preparation work to take place outside the test area in a controlled environment.

    The project has also been made possible thanks to the support of the AMSCI Scheme, administered by Frontier Development Capital, who were established by Finance Birmingham and funded to help innovative British manufacturers grow and compete internationally.

    CFS Aero currently employs 35 people at its Warwick facility and plans to double its workforce over the next four years as demand for its specialist services continues to increase.

    Gareth Sheridan, CFS Aero’s Director responsible for APU operations, commented:

    “We’re proud to be investing in Warwick and to be part of its dynamic manufacturing sector. The new APU Test Cell will help us expand into new markets, create more local jobs, and continue delivering the quality and reliability that CFS Aero is known for.”

    Councillor Naveen Tangri, Chairman of Warwick District Council added:

    “From the Council’s perspective it is extremely rewarding that following our assistance with their relocation from Coventry Airport CFS Aero has put down firm roots in Warwick District and continues to thrive. In addition, their participation in the UKSPF funded Warwickshire Manufacturing Growth Programme is enabling them to bring even more skilled employment opportunities to our area. We want to offer our congratulations for everything they have achieved and look forward to their future success.”

    The opening of the new APU Test Cell marked an important step in CFS Aero’s continuing growth and reinforces Warwick’s standing as a hub for advanced engineering and innovation in the UK.

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  • ESMA publishes latest Spotlight on Markets newsletter featuring updates on market integration and transparency

    The European Securities and Markets Authority (ESMA), the EU’s financial markets regulator and supervisor, has today published the latest edition of its Spotlight on Markets newsletter.

    This edition opens with ESMA welcoming the European Commission’s ambitious proposal on market integration, underlining the importance of deeper, more integrated and efficient EU capital markets and the role of robust governance and market infrastructure in supporting these objectives.

    Another highlight is the announcement of the selected applicant for the equity consolidated tape provider (CTP), a significant milestone towards a more transparent and integrated equity markets landscape in the EU. The newsletter also features ESMA’s final report on Regulatory Technical Standards (RTS) for non-equity transparency, as well as references to the five-year review of tiering and recognition, the report on cross-border investment activity of firms, and a TRV risk article on the application of the fund names guidelines.

    ESMA will also launch a Common Supervisory Action focusing on MiFID II conflicts of interest requirements, reinforcing supervisory convergence and sound governance practices across Member States.

    In parallel, the European Supervisory Authorities (ESAs) have designated critical ICT third-party providers under the Digital Operational Resilience Act (DORA). This represents an important step in strengthening governance and oversight of critical service providers in the EU financial system.

    The newsletter also highlights ESMA’s findings on UCITS distribution costs, contributing to ongoing work on transparency and investor protection.

    Other key topics:

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