Category: 3. Business

  • Graphene-cobalt hexacyanoferrate modified sensor doped with molecularly imprinted polymer for selective potentiometric determination of bupropion

    Graphene-cobalt hexacyanoferrate modified sensor doped with molecularly imprinted polymer for selective potentiometric determination of bupropion

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  • Starian Secures Over US$ 115 Million (R$ 640 Million) Investment from General Atlantic to Accelerate Growth

    Starian Secures Over US$ 115 Million (R$ 640 Million) Investment from General Atlantic to Accelerate Growth

    Funding follows the launch of Starian as an independent multi-vertical software provider to the private sector in June 2025

    Starian intends to use this capital to pursue organic growth and accretive M&A, strengthen its product offerings, and expand into new business verticals

    Florianópolis, August 22, 2025 –Starian (or “the Company”), a leading multi-vertical software provider to the private sector in Brazil, announced that it has secured R$ 640 million (over US$ 115 million) in strategic funding from General Atlantic, a leading global investor. This investment follows the carve-out of Starian from Softplan, one of the largest SaaS technology companies in Brazil, in June 2025. Following the division of operations into two independent businesses, Starian manages all private sector solutions from Softplan, while Softplan continues to focus exclusively on the public sector.

    Starian develops highly specialized vertical software ecosystems to provide end-to-end Software as a Service (SaaS) solutions to private sector businesses in Brazil across three verticals: Construction, built around the Sienge Ecosystem; Legal Intelligence, spearheaded by the Projuris brand; and Operational Efficiency, supported by the operations of the Checklist Fácil and Runrun.it brands. In each of these software verticals, Starian has established itself as a trusted partner in industries that remain fragmented and underpenetrated, with digital adoption still in its early stages. Starian distinguishes itself through its comprehensive functional coverage, localized customer support, and its unique ability to address Brazil’s complex regulatory and compliance requirements, creating deep workflow integrations and durable customer relationships.   

    “Over more than 30 years, we have built a solid foundation that validates our strategy of reinforcing the vertical SaaS model. Now, with a fully autonomous operation and General Atlantic’s funding—bringing not just capital but also global expertise in technology—we can unlock our growth potential faster, strengthen our leadership in existing business units, and expand into new verticals,” said Ionan Fernandes, CEO of Starian.

    Starian currently boasts an initial portfolio of more than 16,000 clients. As it begins on its next stage of growth in partnership with General Atlantic, Starian intends to further pursue organic growth and accretive M&A to expand its capabilities, strengthen its product offerings, and explore new business verticals. 

    “The software landscape in Brazil remains fragmented, and the market is vastly underserved,” said Rodrigo Catunda, Managing Director and Co-Head of General Atlantic in Brazil. “We see Starian as a unique player poised to lead the consolidation of vertical software in Brazil, combining industry-leading products, professionalized management, and a disciplined integration strategy. We are excited to support the company in this new phase of accelerated growth, with a focus on acquisitions and long-term value creation.”

    With the signing of the Share Purchase Agreement (SPA), the transaction’s closing remains subject to customary market conditions, including regulatory approvals and other steps outlined in the timeline.

    About Starian

    Starian is a leading Brazilian multi-vertical software platform operating across three core verticals: Construction, Legal Intelligence, and Operational Efficiency. Starian focuses on building comprehensive ecosystems within its verticals to create winner end-to-end solutions across its market segments. With over 34 years serving the private sector, the company has a workforce of more than 1,500 employees and aims to support 20,000 clients by 2025.

    About General Atlantic

    General Atlantic is a leading global investor with over four decades of experience providing capital and strategic support to more than 830 companies throughout its history. Founded in 1980, General Atlantic continues to be a dedicated partner to visionary founders and investors seeking to build dynamic businesses and create long-term value. The firm leverages its patient capital, operational expertise, and global platform to support a diversified investment platform spanning Growth Equity, Credit, Climate, and Infrastructure strategies. General Atlantic manages approximately $114 billion in assets under management, inclusive of all strategies, as of June 30, 2025, with more than 900 professionals in 20 counties across five regions. For more information on General Atlantic, please visit: www.generalatlantic.com

    Contacts

    Starian
    [email protected] 

    General Atlantic
    Sara Widmann & Jess Gill
    [email protected]

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  • 5 Key Skills to Lead Through Disruption – Harvard Business Review

    5 Key Skills to Lead Through Disruption – Harvard Business Review

    1. 5 Key Skills to Lead Through Disruption  Harvard Business Review
    2. Purpose is the North Star: Why mission-driven companies are thriving in the age of AI  ImpactAlpha
    3. Steering Through Disruption: Strategic Choices in an Ever-Changing Tech Landscape  Vocal
    4. How I Built a Business That Thrives Through Constant Disruption — and How You Can Too  Entrepreneur
    5. Change, Technology, and the Wisdom We Carry Forward  The Washington Informer

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  • Tech frenemies: Meta strikes a $10+ billion AI cloud deal with rival Google

    Tech frenemies: Meta strikes a $10+ billion AI cloud deal with rival Google

    By Christine Ji

    Meta has signed a six-year deal to use Google’s cloud-computing services as it builds out its AI infrastructure

    As Meta races to “build personal superintelligence,” it taps cloud computing resources from Google.

    Meta Platforms Inc. has signed a $10+ billion cloud deal with Alphabet Inc.’s Google to build out its artificial-intelligence infrastructure.

    Meta (META) will use Google’s (GOOGL) (GOOG) cloud-computing services for the duration of the six-year contract, The Information reported.

    The deal counters speculation about a pullback in Meta’s AI ambitions, which followed news that the company had frozen hiring in its AI unit.

    The deal highlights just how intense the AI arms race between the biggest tech companies has become. In July, Meta Chief Executive Mark Zuckerberg said that the company was planning to invest “hundreds of billions of dollars” to develop superintelligence. Meta is building two massive data centers, named Prometheus and Hyperion, which will both provide multiple gigawatts of capacity. The company has also aggressively poached top AI talent from OpenAI and invested $14.3 billion into AI startup Scale AI.

    The sheer scale of developing AI often results in rivals teaming up. While Meta is building out its own data centers, Prometheus isn’t expected to come online until 2026, and Hyperion will take until 2030 to be ready. In the meantime, Meta is looking for immediate access to AI infrastructure through its agreement with Google. To accelerate its timeline, Meta is taking creative measures by housing temporary data-center capacity in tents, the company confirmed last month.

    Earlier this year, OpenAI also partnered up with Google to access its cloud infrastructure. The AI startup had previously exclusively used Microsoft Corp.’s (MSFT) cloud-computing services due to Microsoft’s significant stake in OpenAI. But as compute demand outpaced supply, OpenAI tapped into outside sources.

    Last month, Meta announced during its second-quarter earnings report that it expects total capital expenditures for 2025 to be between $114 billion and $118 billion.

    Representatives from Meta and Google did not immediately respond to MarketWatch’s request for comment.

    Also read: This is the critical detail that could unravel the AI trade: Nobody is paying for it.

    -Christine Ji

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal. 

    
  (END) Dow Jones Newswires
    

    
  08-22-25 0926ET
    

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Analysts Suggest ChatGPT Web Power Is Fading to Old Search Giants

    Analysts Suggest ChatGPT Web Power Is Fading to Old Search Giants

    AI-driven referral traffic is undergoing a significant transformation. Since July 21, referrals from ChatGPT to various websites have plummeted by 52%. It is a major shift sparked by changes in how the platform gathers and prioritizes information. This analysis, which looked at over a billion citations and a million referral visits, shows a clear trend towards platforms like Reddit, Wikipedia, and TechRadar as preferred sources for quick answers.

    Josh Blyskal from Profound has shed some light on the situation:

    Citations from Reddit have skyrocketed by 87% since July 23, now making up over 10% of all ChatGPT citations.

    Wikipedia has also seen a 62% increase from its low in July, reaching nearly 13% of the share.

    When combined with TechRadar, these three sites now account for 22% of all citations, a remarkable 53% rise in just a month.

    This shift started even before the release of GPT-5, suggesting that the changes in citation weighting are intentional rather than a result of modifications to the underlying model.

    OpenAI’s reshuffling of citations seems to favor communities that provide straightforward answers, boosting the visibility of general informative sources while pushing branded content further down the list. Blyskal advises brands to shift their focus from conversion-driven messaging to creating valuable, educational content that addresses the actual questions users are asking.

    Multiple analyses highlight the instability of ChatGPT referrals and emphasize the increasing need to optimize content specifically for visibility in AI.

    On a broader scale, industry leaders like Cloudflare CEO Matthew Prince are warning that these trends could jeopardize the traditional internet model that relies on referral traffic. As AI “answer engines” take over search navigation, content creators might find themselves losing crucial visibility, and revenue.

    News publishers are also feeling the pinch, facing a decline in organic traffic not only from AI platforms but from traditional sources as well. Google’s AI Overviews have cut referral traffic by as much as 25%, making it even tougher for publishers to maintain their audience.

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  • James D. Chalmers, MBChB, PhD

    James D. Chalmers, MBChB, PhD

    In part 2 of an interview with James D. Chalmers, MBChB, PhD, professor of respiratory medicine at the University of Dundee in Scotland, he expands upon the safety and tolerability profile of brensocatib (Brinsupri; Insmed), which received FDA approval last week for the treatment of patients with non–cystic fibrosis bronchiectasis.

    Watch part 1 to hear his insights on the ASPEN trial (NCT04594369) that supported this approval and how the therapy may change the treatment landscape for this patient population.

    This transcript has been lightly edited for clarity; captions are auto-generated.

    Transcript

    What should clinicians know about the safety and tolerability profile of brensocatib? How do you expect it to be managed in practice?

    The safety was very reassuring. The incidence of adverse events—which is always what we look for in clinical trials—and serious adverse events were very similar between the placebo group and the 2 treatment groups, so there was no evidence that there was any significant safety issue.

    We particularly look for the frequency of infections because, I think, clinicians, when they hear that you’ve got an anti-inflammatory drug, they think, “Oh, is that going to increase the risk of infection?” The really reassuring thing to let everyone know is that there was no increased risk of pneumonia or other types of infections, which is remarkable for a treatment that targets the neutrophil as an anti-inflammatory approach. That’s also really reassuring.

    There is this rare genetic condition called Papillon-Lefèvre syndrome, which is incredibly rare, and it’s caused by a knockout in this gene called dipeptidyl peptidase 1, which is the mechanism of action of the drug. We look very carefully for dental adverse effects and skin adverse effects, because those are the manifestations of that disease.

    We don’t see any dental issues in the trial, and there were no clinically significant issues either in the phase 2 trial from a dental point of view. The only thing that really showed up in the phase 3 trial was this slightly higher frequency of hyperkeratosis. Just to put that in some context for your viewers, there were 4 cases in the placebo group, 8 cases in the 10 mg group, and 16 cases in the 25 mg group.

    When you consider that there are more than 500 patients in each of those arms, these are quite rare [adverse] effects. Importantly, they were mild and manageable. There was actually only 1 patient in the whole trial who discontinued because of their hyperkeratosis as an adverse effect.

    In practice, I don’t think we’re going to have any significant issues with this. Some patients will develop a bit of hyperkeratosis that seems to respond in the trial to a treatment interruption; it just goes away. That’s how I would expect to manage it in clinical practice.

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  • 10 things to watch in the stock market Friday including the Fed and Nvidia’s China plans

    10 things to watch in the stock market Friday including the Fed and Nvidia’s China plans

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  • Alibaba.com Honors Pakistan’s Top Exporters, Unveils Major Trade Assurance Upgrade

    Alibaba.com Honors Pakistan’s Top Exporters, Unveils Major Trade Assurance Upgrade

    Alibaba.com, a leading global business-to-business (B2B) e-commerce platform, today celebrated the nation’s top e-commerce businesses at the KEL Awards 2025 ceremony while launching its enhanced Trade Assurance 2.0 service in Pakistan. The event brought together key industry leaders, including Omer Khalid, Vice President of SCCI and Sayyed Ahmad Masud, Project Director of the National Incubation Center Islamabad, to honor local exporters who have leveraged Alibaba.com to transform their operations and expand their businesses globally.

    The launch of Trade Assurance 2.0 was a key highlight, introducing major enhancements designed to empower Pakistani exporters. This updated service directly addresses their needs by offering reduced transaction fees, free withdrawals, higher order and credit limits, and more payment options, empowering local businesses to conduct international trade with greater efficiency and security.

    “Pakistan represents a high-potential supplier market for Alibaba.com, boasting robust production capabilities and a diverse range of product categories that capture substantial global buyer interest. To capitalize on this potential, we have deliberately upgraded Trade Assurance 2.0 to provide suppliers with the essential tools to overcome challenges related to cost and credit. This service is designed to enable Pakistani businesses to secure higher-value orders and drive substantial growth in their global operations.” said Summer Gao, Head of Global Supply Chain Services at Alibaba.com.

    Honoring Pakistan’s Top Global Exporters

    The KEL Awards 2025 showcased the remarkable achievements of six Pakistan’s top e-commerce finalists, each delivering insightful presentations on the strategies that fueled their success on the Alibaba.com platform. The ceremony honored top performers across a wide range of sectors, from apparel to surgical goods, with winners recognized in two categories, Global Trade Innovators and E-commerce Export Masters.

    This year’s top honors of Alibaba.com Pakistan Key E-commerce Leader were awarded to Mr. Muhammad Usman Humayun from Gray Rocks Enterprise, Mr. Haider Ali from IMPEX Pakistan, and Mr. Muhammad Azam Rahmat from Mangoes Fashion. Additionally, the event featured a People’s Choice Award for 2025, which was presented to Mr. Muhammad Wasim from Blue Hands International based on audience voting. The finalists were evaluated by a distinguished judging panel with the challenging mission of selecting the winners including, Omer Khalid (Vice President of SCCI), Sayyed Ahmad Masud (Project Director of National Incubation Center Islamabad), Usman Chughtai (Key E-commerce Influencer), Berry Ma (Head of Pakistan Business, Alibaba.com), Summer Gao (Head of Global Supply Chain, Alibaba.com).

    Berry Ma, Head of Pakistan Business at Alibaba.com, emphasized the significance of the awards, stating, “The Pakistan KEL Awards are more than just a competition. They’re a powerful celebration of the ingenuity and resilience of Pakistan SMEs. We’re honored to provide a platform that enables exporters to not only succeed but also inspire. These finalists prove that with the right tools, Pakistani businesses can push the boundaries of global trade and seize opportunities in the global marketplace.”

    One of the six finalists, Muhammad Azam Rehmat, from Mangoes Fashion shared a compelling story that underscores the transformative power of ambition and innovation in e-commerce. As a farmer’s son, began his two-person garments company, Mangoes Fashion, in 2020. Despite having local manufacturing expertise, breaking into the competitive global market felt nearly impossible without a trusted channel to connect with international buyers. The solution came in 2021 when the company joined Alibaba.com. By leveraging the platform’s ecosystem and securing a Verified tag, Mangoes Fashion gained the credibility and visibility needed to transform its small-scale operation into a global venture, providing a direct channel to buyers worldwide.

    The results were transformative and rapid. Mangoes Fashion achieved over 200% annual growth, securing landmark deals including a single order worth $62,545 and six subsequent orders of $20,000 each. Today, what started as a small team exports apparel to key markets across the United States, Europe, Australia, and Canada, proving that local businesses can leverage digital tools to achieve significant global success. This impressive growth was not only a highlight of Azam’s entrepreneurial journey but also serves as an inspiration for aspiring entrepreneurs in Pakistan to harness technology in the pursuit of their dreams.

    Finalists in the Alibaba.com KEL Award 2025 Finale include:

    ● Mr Muhammad Wasim from Blue Hands International

    ● Mr Haider Ali from IMPEX Pakistan

    ● Mr Usman Asif from Moytei Sports

    ● Mr Muhammad Azam Rahmat from Mangoes Fashion

    ● Mr Imran Iqbal Bajwa from Producing Peak

    ● Mr Muhammad Usman Humayun from Gray Rocks Enterprise


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  • Tech war: which Chinese firm is supplying next-generation AI chips to DeepSeek?

    Tech war: which Chinese firm is supplying next-generation AI chips to DeepSeek?

    The Hangzhou-based start-up’s cryptic one-line post on WeChat triggered online discussions about which AI chip supplier, or suppliers, would unveil this breakthrough, even as US tech restrictions remain in place.
    DeepSeek’s post on Thursday said the “UE8M0 FP8 scale” of its V3.1 AI model was particularly designed “for home-grown chips to be released soon”. Apart from not identifying the supplier, the firm did not specify how the new AI chips would be used – for training of models or inferencing, the stage where an AI system puts its learning into action.
    “It’s also likely that the new model will support a number of AI chips, not just those from Huawei or another company,” Liu Jie, an engineer at a Shanghai-based developer of graphics processing units (GPUs), said on Friday.

    The speculation reflects not only growing confidence in the capabilities of locally designed and produced integrated circuits, but also how China’s semiconductor industry has steadily overcome US tech sanctions.

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  • Surging US LNG exports to fuel growth in shale gas production – Reuters

    1. Surging US LNG exports to fuel growth in shale gas production  Reuters
    2. US gas-heavy power pipeline set to stoke LNG exporter tensions  Reuters
    3. Evan Simon, Floodlight  WWNO
    4. Expanded LNG exports bring pollution, rising prices, and resistance along the Gulf Coast  ehn.org
    5. Trump-fueled LNG boom has fenceline Gulf Coast communities on edge  Louisiana Illuminator

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