Category: 3. Business

  • Intuit Unveils Revolutionary System of Intelligence to Help Businesses Grow in the AI Era :: Intuit Inc. (INTU)

    Intuit Unveils Revolutionary System of Intelligence to Help Businesses Grow in the AI Era :: Intuit Inc. (INTU)





    New Intuit Accountant Suite, enhanced AI-native Enterprise Suite ERP solution, and Small Business innovations combine data, AI agents, and human expertise in one place to power prosperity

    LAS VEGAS–(BUSINESS WIRE)–
    Intuit Inc. (Nasdaq: INTU), the global financial technology platform that makes Intuit TurboTax, Credit Karma, QuickBooks, and Mailchimp, announced today major innovation to its all-in-one platform, including the introduction of Intuit Intelligence, a revolutionary system of intelligence that provides businesses and accounting firms with everything they need to compete and grow in the AI era. The announcement also included the launch of Intuit Accountant Suite, a new AI-native solution for accountants; new AI agents that transform how businesses run and grow; and several powerful enhancements to Intuit Enterprise Suite, the company’s modern ERP solution that serves growing mid-market businesses.

    Intuit CEO Sasan Goodarzi unveiled these transformational innovations before global accounting leaders at Intuit Connect, the company’s flagship event for multi-service accounting firms and professionals.

    “We are leading the largest technology disruption in our history that will fundamentally change how businesses compete and grow,” said Intuit CEO Sasan Goodarzi. “We’re creating the future, leveraging the power of data, AI, and human intelligence to give all businesses on the Intuit platform a distinct advantage to thrive in this new era.”

    Intuit Intelligence: A revolutionary system of intelligence that provides businesses with what they need to compete and grow

    At the core of Intuit’s all-in-one platform transformation is Intuit Intelligence, a revolutionary system of intelligence that will unify a business’s data and provide access to a powerful, virtual team of AI agents across all financial pillars—including growing and managing customers, payments, payroll, accounting, and tax. Intuit Intelligence is simple, ‘Ask Anything’:

    • Instant, Accurate Answers: Customers can ask any business question— from “How do I turn leads into sales?” to “What’s my projected profitability?”— and receive immediate, data-backed answers and customized recommendations that drive growth.

    • Automated Task Completion: Simply use a prompt, like “Run my payroll,” to complete complex tasks automatically, or build custom solutions that provide businesses with actionable insights that matter most to them.

    • Actionable Insights: Securely ingesting data from Intuit sources, third-party systems, and spreadsheets, Intuit Intelligence will instantly generate rich insights, reports, and KPI scorecards that drive confident, faster decisions.

    An All-in-One Platform with a Virtual Team of AI Agents and Trusted Human Experts

    Intuit’s all-in-one platform, powered by Intuit Intelligence, unlocks a virtual team of AI agents and trusted human experts who together deliver done-for-you experiences, data-backed insights, and recommendations that drive faster, more confident decisions. Now with new and enhanced embedded AI agents, including the sales, payroll, customer, payments, finance, project management, and accounting agents, businesses save as much as 12 hours a month with simplified day-to-day operations and access to insights that drive productivity and profitability. New and enhanced AI agents, along with a deeper integration of human expertise, introduced across the platform include:

    • NEW! Sales Tax Agent: Will help keep a business compliant by charging the correct sales tax for products and services, identifying potential sales tax issues, and suggesting fixes before filing.

    • NEW! Payroll Agent: Helps ensure payroll is run accurately and on-time, by proactively collecting hours directly from employees, spotting anomalies, generating insights, and sending a ready-to-approve payroll draft via text.

    • IMPROVED! Accounting Agent: Expanded anomaly detection, AI-powered reconciliations, and more accurate automated transaction categorizations across classes and dimensions, deliver cleaner, more accurate books.

    • IMPROVED! Project Management Agent: Now converts signed contracts into projects during project set-up, provides deeper project profitability insights that take into account changes in project scope or item cost increases, all summarized on a refreshed project overview dashboard.

    • More customised support from AI-Powered trusted human experts: Get the most out of the Intuit platform from day one, with Intuit experts who have access to AI-powered tools and agents to deliver guided set-up and onboarding, ongoing bookkeeping, and soon data migration and quarterly books and tax reviews.

    A Disruptive AI-Native Mid-Market Platform that Fuels the Success of Growing Businesses

    Intuit is redefining the mid-market ERP landscape with Intuit Enterprise Suite, a modern, AI-native ERP solution with built-in automation for multi-entity management, instant AI-driven insights, and a virtual team of AI agents. This AI-native solution offers a powerful alternative to costly, complex, and slow-to-implement legacy systems. Intuit Enterprise Suite is fast to deploy, easy to learn, and cost-effective to scale. Expanded and enhanced capabilities include:

    • Access to More Intuit AI Agents: Transform how a business runs with access to a virtual team of AI agents, from project management, to finance, payroll, payments, and more, that deliver done-for-you experiences and data-backed insights that save time and drive faster, better decision making.

    • Faster Onboarding: Improved data importing and AI-driven suggestions will standardize Chart of Accounts across entities and with new dimension capabilities, businesses optimize operations, focus on higher-value work, and simplify transaction management.

    • Advanced Multi-Entity Management: Expanded user controls and advanced multi-entity reporting will improve financial accuracy and decision-making. A new consolidated control center will allow businesses to manage apps, such as payroll, across entities, while AI-powered automations will detect anomalies, execute tasks, and surface personalized insights and actions.

    • Enhanced Reporting and KPI Dashboards: An extended catalog of financial and non-financial reports, combined with intelligent KPI dashboards, will deliver deeper, organization-wide insights into business performance.

    • Industry-Specific Editions: Beginning with construction, Intuit Enterprise Suite will soon offer tailored workflows, capabilities, and tools designed for larger, more complex, multi-entity construction businesses, helping them win and deliver more profitable projects on time.

    Intuit Accountant Suite: Putting Intuit Platform Power in the Hands of Accountants to Fuel Their Success

    The new Intuit Accountant Suite is an AI-native platform that helps firms manage their clients, practices, and teams, all in one place. Built for and with accountants, Intuit Accountant Suite is backed by the power of Intuit’s platform and system of intelligence. Intuit Accountant Suite:

    • Unifies Firm Management: Seamlessly integrates client management, collaboration, service delivery, business planning, and team management—all from a comprehensive, customizable dashboard.

    • Improves Client Collaboration: Provides document sharing and soon integrated web conferencing, meeting scheduling, and AI note-taking tools to ensure exceptional client service.

    • Answers Questions and Automates Tasks: With Intuit Intelligence, business questions like “Who’s my most profitable client?” will be immediately answered and tasks like “Run my payroll” along with the creation of firm-wide and client-specific reports and dashboards will automatically be completed because of secure access to Intuit and client data and data from third-party systems.

    • Improves Firm Capacity: Access to AI-powered capacity planning and forecasting and the ability to tap into Intuit’s trusted human experts will help firms better serve their clients when extra hands and specialized support are needed.

    Availability

    The new Intuit Accountant Suite, and Intuit’s system of intelligence, new AI-agents and access to experts, start rolling out to US-based businesses and accountants today in QuickBooks and Intuit Enterprise Suite. US QuickBooks customers will also soon see some agentic AI experiences in mobile.

    With integrated, powerful AI, automated workflows, and seamless collaboration with trusted experts, businesses and accounting firms on the Intuit platform gain real-time, personalized insights that help them move faster, operate smarter, and uncover new efficiencies and growth opportunities.

    About Intuit Connect

    Returning to Las Vegas for a fourth year, Intuit Connect brings together thousands of accounting professionals and leaders from high-growth, multi-service firms that serve small and growing mid-market businesses. Across three days of programming, accountants foster connections with one another, earn continuing professional education credits, hear from influential speakers, and see the latest Intuit platform innovations for all customers and accountants across Intuit Enterprise Suite, QuickBooks, and Mailchimp.

    About Intuit

    Intuit is the global financial technology platform that powers prosperity for the people and communities we serve. With approximately 100 million customers worldwide using products such as TurboTax, Credit Karma, QuickBooks, and Mailchimp, we believe that everyone should have the opportunity to prosper. We never stop working to find new, innovative ways to make that possible. Please visit us at Intuit.com and find us on social for the latest information about Intuit and our products and services.

    Feature availability varies by product.

    Experts only available with QuickBooks Live.

    1. 45% of customers save 12 hours each month on monthly bookkeeping with the new AI-powered bank feed. Based on a survey commissioned by Intuit of QuickBooks Online customers using the new AI-powered bank feed features as of April 2025.

    Money movement services are provided by Intuit Payments Inc., licensed as a Money Transmitter by the New York State Department of Financial Services. For more information about Intuit Payments’ money transmission licenses, please visit https://www.intuit.com/legal/licenses/payment-licenses/.

    This information is intended to outline our general product direction, but represents no obligation and should not be relied on when making a purchasing decision. Additional terms, conditions and fees may apply with certain features and functionality. Eligibility criteria may apply. Product offers, features, and functionality are subject to change without notice.

    Intuit Media Contact:

    Kim Amsbaugh,

    Kim_Amsbaugh@intuit.com

    Source: Intuit Inc.

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  • Proposed tariffs may impact trade finance in Europe

    Proposed tariffs may impact trade finance in Europe

    Trade finance has long been a cornerstone of supporting economic growth and global prosperity. However, recent developments in protectionist trade policies have heightened concerns about geopolitical risks and the stability of global supply chains.

    Despite these challenges, trade finance remains resilient. It continues to be a vital tool for organizations seeking to facilitate growth, manage emerging risks, and adapt to shifting trade dynamics. Trade credit insurance plays a crucial role by protecting businesses against customer defaults and non-payment, especially amid increasing trade uncertainties.

    How trade finance and protectionist policies are interconnected

    Post-World War II, supportive trade policies helped reduce the global average tariff rate from around 15% to approximately 5%, boosting international trade’s contribution to global GDP from 20% to nearly 50% before the 2008 financial crisis. However, subsequent years saw a slowdown, with trade’s share of global GDP stagnating and trade finance growth remaining subdued at just 1.4% CAGR between 2010 and 2015.

    From 2018 to 2023, trade finance experienced some recovery, but the landscape was marred by a fourfold increase in government interventions, geopolitical disruptions — including the Russia-Ukraine war — and rising interest rates. Trade tensions and EU sanctions against countries including Russia, have further complicated trade, especially with key trading partners like China and the US.

    While government support in 2020 and 2021 helped stabilize insolvency rates, the end of these measures, coupled with tighter monetary policies, has led to a rise in insolvencies across Europe. This environment underscores the importance of robust trade finance strategies, including trade credit insurance, to mitigate against current and future risks.

    The 2025 outlook for trade finance and trade policy in Europe

    Looking ahead, credit insurers anticipate that insolvency growth rates will stabilize at elevated levels amid ongoing macroeconomic uncertainties. However, significant tail risks persist. For example, although the European Central Bank (ECB) eased monetary policy by lowering interest rates in March 2025 and maintained them in September 2025 — measures expected to alleviate some systemic pressure — the unpredictable nature of the current trading conditions remains a concern. Whether driven by tariffs, sanction policies, energy market developments, or other unforeseen factors, the risk of a downside economic event capable of stressing balance sheets remains elevated.

    As Europe seeks to redefine its role in the transatlantic relationship, it is also reassessing its ties with China. The European Commission has voiced concerns about the baseline 15% tariff imposed by the US on EU exports, especially for key sectors. Discussions on content moderation and digital competition, as well as technology taxes, could further complicate trade flows. While China is the EU’s second-largest trading partner, relations have become increasingly complex amid disagreements on competitiveness, export controls, and the issue of the Russia-Ukraine war.

    Furthermore, the Global Trade Policy Uncertainty Index is at its highest since records began in 1960, reflecting widespread uncertainty that could deter investment and disrupt supply chains across Europe. This uncertainty is particularly impactful for less-diversified businesses and those most impacted by US tariffs, such as chemicals, machinery, and vehicles, or sectors that had developed a reliance on exports to China, including manufactured goods.

    Potential impacts of tariffs on European trade finance

    In 2025, the threat of disruption appears more significant from previous US tariffs. In 2019, US tariffs affected almost US$7.5 billion worth of European products, while in 2025, the EU’s Trade Commissioner stated that about 70% of EU exports to the US, valued at €382 billion (approximately US$449 billion), are currently affected by US tariffs.

    Longer-term, these tariffs could reduce global trade values by more than 7% by 2030, with Europe potentially bearing a substantial share of this decline.

    While the EU and the US seem to have reached a temporary resolution on trade, the risk of additional US tariffs targeting critical EU sectors (such as pharmaceuticals), remains. Coupled with the potential for future economic and political developments to reignite tensions, businesses may consider the implications of further disruptive trade measures and counter actions. 

    Protecting your business with trade credit insurance

    Given the uncertain environment, the risk of insolvencies surpassing forecasts warrants serious consideration — especially for key suppliers and distributors in exposed markets.

    Trade credit insurance remains a proven tool for managing these risks. It provides coverage for losses due to supplier or counterparty insolvencies, regardless of whether defaults are caused by tariffs, trade barriers, or other geopolitical factors. As supply chains evolve and new routes emerge, businesses may increasingly rely on trade finance and credit insurance to safeguard their transactions.

    It is advisable for companies to review their existing trade credit policies, ensuring they include coverage for defaults triggered by government actions and trade policy disruptions. Businesses without such policies are encouraged to consult with their Marsh representative to assess their risk exposure and explore suitable protective measures.

     

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  • Targeted T-cell Therapy Beneficial in Rare Form of Melanoma – Medscape

    1. Targeted T-cell Therapy Beneficial in Rare Form of Melanoma  Medscape
    2. Eyes Widen for Uveal Melanoma Treatment: Sapna Patel’s Groundbreaking Findings at ESMO 2025  CU Anschutz newsroom
    3. Immatics (IMTX) Is Up 8.6% After Strong Anzu-cel Trial Data in Metastatic Uveal Melanoma—Has the Bull Case Changed?  simplywall.st
    4. ESMO 25: Immatics Makes An Impact With Stellar Rare Eye Cancer Data  Citeline News & Insights
    5. Novel T-Cell Therapy Promising in Tough-to-Treat Eye Cancer  MedPage Today

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  • ShebaMiles and Etihad Guest Loyalty Program Partnership Launch

    Addis Ababa, 28 October 2025

    Ethiopian Airlines, the largest airline in Africa and one of the fastest growing airline brands globally, is excited to announce a partnership between its loyalty program, ShebaMiles, and Etihad Airways’ loyalty program, Etihad Guest, effective October 2025.

    The ShebaMiles program has been operating for more than 26 years and has a membership base of over 5.38 million. ShebaMiles has four tier levels — Blue, Silver, Gold, and Platinum — offering increasing benefits, engagement, and recognition for premium members.

    Regarding the program partnership, Ethiopian Airlines Group Marketing Vice President Mrs. Rahel Assefa said, “As a customer centric airline, we are delighted to expand our passengers’ connectivity and flexibility in earning miles. This program partnership is a great opportunity for loyalty program members of both airlines. At Ethiopian, we continue to elevate our passengers’ experience through innovation and meaningful partnerships.

    In addition to its loyalty program, Ethiopian partners with 25 Star Alliance member airlines and maintains partnerships with strategic airline partners across Africa and with Gol Airlines of Brazil.

    The Etihad Guest loyalty program has been in operation for over 19 years and serves a membership base of more than 12 million. Etihad Guest has five tier levels — Bronze, Silver, Gold, Platinum, and the exclusive Emerald — and its award-winning program now features partnerships with 26 airlines, the largest portfolio of airline partners outside an alliance.

    Mark Potter, Managing Director Etihad Guest, commented, “We’re delighted to welcome Ethiopian Airlines as a frequent flyer partner, expanding the benefits and opportunities available to our Etihad Guest members across Africa and beyond. This partnership reflects our commitment to rewarding our guests with greater choice, flexibility, and seamless connectivity as part of the growing cooperation between our airlines. With the launch of our flights between Addis Ababa and Abu Dhabi, we’re proud to strengthen ties with one of Africa’s leading carriers and look forward to offering even more value to our loyal members and welcoming ShebaMiles members onboard.

    Both loyalty programs provide compelling opportunities to earn and redeem miles through flights and through diverse non-airline partnerships, including financial institutions, hotels, car rental companies, shopping centers, co-branded cards, points exchanges, and more.

    This partnership provides frequent flyers of both programs with improved connectivity, greater flexibility, and more convenience in earning and redeeming miles, as well as consistent recognition and seamless delivery of benefits for premium members across our global networks.

    About Ethiopian

    Ethiopian Airlines Group (Ethiopian) is a true African success story, transforming a visionary dream into a globally renowned reality for nearly eight decades. Operating flights to more than 160 domestic and international passenger, and cargo destinations across five continents, Ethiopian bridges the gaps between Africa and the world. Emphasizing passenger comfort and environmental sustainability, Ethiopian utilizes ultra-modern aircraft such as Boeing 737s, 777s, 787s, Airbus A350-900, A350-1000 and De Havilland Q400.

    Ethiopian, the Star Alliance member airline, champions in various coveted awards including Skytrax’s ‘Best Airline in Africa Award’ for eight consecutive years, APEX ‘Best Overall in Africa’ award and ‘Leadership in Connecting Africa through Transport’ Award among others. Ethiopian aims to further excel in its success through a strategic plan dubbed ‘Vision 2035’ and become one of the top 20 most competitive and leading aviation groups in the world. Embracing a Pan-African spirit, Ethiopian is pursuing multi-hub strategy through hubs in Lomé, Togo with ASKY, in Lilongwe, Malawi with Malawi Airlines, in Lusaka, Zambia with Zambia Airways, and in Kinshasa, Democratic Republic of the Congo (DRC) with Air Congo.

    For more information, visit our website at  www.ethiopianairlines.com  email us at CorporateCommunication@ethiopianairlines.com , or call us at (251-11)517-8913/8165/8907.

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  • The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

    The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

    Microtubular transport of different organelles within the lysosomal system is essential for their proper function. Among the small GTPases that regulate late endosome/lysosome positioning, Rab7 (Fujiwara et al., 2016; Jordens et al., 2001; Ma et al., 2018; van der Kant et al., 2013) and Arl8 (Bagshaw et al., 2006; Boda et al., 2019; Hofmann and Munro, 2006; Marwaha et al., 2017; Rosa-Ferreira and Munro, 2011; Rosa-Ferreira et al., 2018) are well-studied. However, the positioning of autophagosomes is less understood. Autophagosome transport has been primarily studied in highly polarized neurons under basal conditions. In neuronal cells, dynein-mediated transport, regulated by several suggested adaptor molecules, has been described. However, most reporters and reagents used for studying autophagosome transport cannot differentiate between pre-fusion and post-fusion autophagic vesicles. Therefore, the regulation of non-fused autophagosome motility remains unclear. We propose that an autophagosome should not be considered as such once its lumen has started to acidify or undergo fusion, transitioning to a maturing autolysosome.

    To address this issue, we established a genetic system generating mosaic cells where Vps16A, a central HOPS subunit, is silenced. Without Vps16A, cells are unable to fuse autophagosomes with lysosomes or late endosomes (Takáts et al., 2014), thus preventing the formation of autolysosomes. This system allowed us to study autophagosome positioning without misidentifying autolysosomes as autophagosomes. Given that fat cells have perinuclear non-centrosomal MTOCs, we hypothesized that non-fused autophagosomes move in a minus-end direction, likely driven by dyneins. This hypothesis was supported by our observation that relocating the ncMTOC using shot RNAi also relocated autophagosomes to this region.

    Loss of dyneins and dynactins not only blocked perinuclear autophagosome positioning but also redistributed them to the cell periphery, suggesting that kinesin-regulated motility becomes available for starvation-induced autophagosomes in these conditions. Importantly, we showed that not all dyneins or dynactins are required for this transport. A dedicated cytosolic dynein complex, composed of Dhc64 (a heavy chain subunit), sw (an intermediate chain subunit), Dlic (a light intermediate chain subunit), and robl (a light chain subunit), activated by a dynactin complex, is required for autophagosome transport. This is consistent with observations that autophagosomes can move bidirectionally in neurons and that purified autophagosome fractions contain both dyneins and kinesins (Maday et al., 2012). Our results also reinforce findings that microtubule inhibitors block centrosome-directed autophagosome transport in mammalian cells (Fass et al., 2006).

    Taking these observations into consideration, we investigated the relationship between dyneins and kinesins in autophagosome transport. Overexpression of kinesin motors blocked minus-end transport, while autophagosomes in kinesin and dynactin double knockdown cells appeared immobile. Moreover, expressing a recombinant minus-end kinesin (Clark et al., 1997) partially rescued the peripheral relocation of autophagosomes upon dynactin silencing, indicating a competitive relationship between minus- and plus-end motors in autophagosome positioning. The possibility of plus-end transport as a secondary mechanism raises questions about its physiological role. Besides enabling bidirectional movement (Jahreiss et al., 2008; Maday et al., 2012), it is possible that autophagosomes transport kinesins to autolysosomes, similar to endosomes, which are suggested to transport dyneins to autophagic vacuoles (Cheng et al., 2015). Therefore, if kinesins are present but are downregulated on autophagosomes, the absence of dyneins could potentially release them from inhibition. Autophagic vesicles are suggested to move towards the plus end (Mauvezin et al., 2016; Pankiv et al., 2010), and loss of various kinesins leads to autophagosome accumulation in the cell center in mammalian cells (Cardoso et al., 2009; Korolchuk et al., 2011). The plus-end transport of autophagic vesicles by the Klp98A kinesin in Drosophila promotes autophagosome-lysosome fusion and degradation (Mauvezin et al., 2016). However, our tests indicated that Rab14 and its interactor Klp98A likely transport autolysosomes, not autophagosomes, as evidenced by the non-autophagosomal localization of YFP-Rab14 and that their RNAi-s had no effect on autophagosome positioning in starved, HOPS-depleted cells. Since neither kinesin RNAi altered the perinuclear accumulation of autophagosomes in Vps16A-depleted cells, we propose that the default direction is towards the MTOC at the minus-ends of microtubules.

    Among Rab small GTPases, we identified Rab7 and Rab39 as regulators of autophagosome positioning. Rab7, crucial for autophagosome-lysosome fusion, appears on autophagosomes (Hegedűs et al., 2016). Its knockdown resulted in autophagosomes remaining randomly positioned in the cytosol, highlighting its importance in bidirectional motility. Consistent with our findings, Rab7 regulates both minus- and plus-end directed motility of lysosomes or endosomes, involving several adaptors such as Plekhm1 and FYCO1 (Fujiwara et al., 2016; Jordens et al., 2001; Ma et al., 2018; Pankiv et al., 2010; Tabata et al., 2010; van der Kant et al., 2013). However, only one Rab7 interactor, the autophagy adaptor Epg5 (Gillingham et al., 2014; Wang et al., 2016), produced a similar phenotype to Rab7 in our tests. Additionally, we demonstrated that Epg5 coprecipitates with Dhc64C, and localizes to Rab7 and Atg8a-positive vesicles in cultured fruit fly cells. As Epg5 loss did not significantly impact the endolysosomal system, it appears to function in the autophagic pathway. Epg5 interacts with Rab7 and LC3 to mediate autophagosome-lysosome fusion in fly, worm, and mammalian cells (Hori et al., 2017; Wang et al., 2016), and its mutations are linked to Vici syndrome, a severe neurodegenerative disorder in humans (Balasubramaniam et al., 2018; Byrne et al., 2016; Meneghetti et al., 2019). We thus identify a potential new role for Epg5 in autophagosome positioning.

    Silencing Rab39 and its interactor ema (Gillingham et al., 2014) produced a phenotype similar to Rab7 or Epg5 loss. Rab39 regulates lysosomal function and interacts with HOPS in mammalian cells (Lakatos et al., 2021; Zhang et al., 2023). Ema promotes autophagosome biogenesis (Kim et al., 2012) and endosomal maturation through HOPS interaction (Kim et al., 2010). Our results suggest that Rab7-Epg5 and Rab39-ema interactions are both necessary for bidirectional autophagosome motility. Further studies are required to clarify their exact roles and interrelations. YFP-tagged Rab7 and Rab39 both colocalized with autophagosomes, supporting their role in motility. Rab2, Rab7, and Arl8 are known lysosomal fusion factors (Boda et al., 2019; Hegedűs et al., 2016; Lőrincz et al., 2017b), but unlike Rab7, neither Rab2 nor Arl8 knockdown affected autophagosome positioning. Since YFP-Rab2 was also found to colocalize with autophagosomes, our results suggest that its sole role on autophagosomes is to regulate maturation. Although our RNAi screen identified a molecular machinery potentially sufficient for autophagosome transport, other small GTPases, adaptors, or motor subunits may also influence this process. Because validating the proper loss-of-function effect for every RNAi line used in the screen was impractical, we cannot exclude the possibility that some negative results were due to inefficient silencing. It is also important to note that Drosophila cells exhibit a wide variety of microtubule-organizing centers (MTOCs) during development, including both centrosomal and non-centrosomal types (Tillery et al., 2018). A key future direction will be to examine autophagosome motility in additional cell types to determine whether the same positioning machinery operates universally, or whether cell-type–specific mechanisms exist.

    Given the small Arl8-positive lysosomes in the perinuclear region upon Vps16A silencing, we hypothesized that pre-fusion lysosomes might exhibit similar motility to autophagosomes. This was largely confirmed, as minus-end transport of immature lysosomes depended on dyneins, Rab7, Rab39, and ema. However, Epg5 did not influence lysosome positioning, indicating that its function is likely exerted at the surface of autophagosomes. Conversely, Rab2 was identified as a regulator of minus-end-directed lysosome transport. These findings suggest similar but distinct regulatory mechanisms for pre-fusion organelle transport, possibly to enhance fusion efficiency by converging them towards the cell center. Rab2’s interaction with motor adaptors such as Bicaudal D (Gillingham et al., 2014) likely regulates lysosome motility.

    Moreover, mature autolysosomes, but not pre-fusion ones, redistributed to the cell periphery upon Rab39 silencing, similar to dynein-depleted cells, suggesting that Rab39 exclusively regulates minus-end movement at the post-fusion level. Considering that plus-end directed lysosome motility is regulated by Arl8 (Bagshaw et al., 2006; Boda et al., 2019; Hofmann and Munro, 2006; Marwaha et al., 2017; Rosa-Ferreira and Munro, 2011; Rosa-Ferreira et al., 2018), which is dispensable for autophagosome motility, it is plausible that Rab39 promotes bidirectional transport of pre-fusion organelles, while its role post-fusion is restricted to minus-end directed motility.

    An important question is why pre-fusion autophagosomes and lysosomes travel to the same destination. It is feasible to think this is because they need to fuse with each other. We found that loss of minus-end directed motility reduced autolysosome maturation; in dynein- or dynactin-depleted cells, only smaller autolysosomes were produced, and autophagosome-lysosome fusion decreased. This aligns with previous observations that dynein-regulated autophagosomal motility is indispensable for efficient lysosomal fusion (Jahreiss et al., 2008; Kimura et al., 2008). Conversely, inhibiting kinesins did not impede autophagosome-lysosome fusion, and concentrating autophagosomes and lysosomes to a smaller ectopic ncMTOC via shot RNAi resulted in enlarged lysosomes, allowing autophagosome-lysosome fusion to proceed.

    Therefore, we propose a model in which pre-fusion organelles travel towards the MTOC in a cytosolic dynein-dependent manner regulated by small GTPases and their adaptors (Rab7-Epg5 and Rab39-ema on autophagosomes; Rab7, Rab39-ema, and Rab2 on lysosomes) to enhance fusion probability. After fusion, autolysosomes can move to the periphery in an Arl8-dependent manner and back, regulated by Rab39 (Figure 11).

    Model of the transport of autophagosomes and lysosomes in starved fat cells.

    Before fusion, autophagosomes and lysosomes are transported towards the perinuclear non-centrosomal microtubule organizing center (ncMTOC) by a cytosolic dynein complex in starved fat cells to ensure proper fusion and effective degradation. This process requires Rab7, Rab39, and their interactors Epg5 and ema on autophagosomes, and Rab2, Rab7, Rab39, and the Rab39 interactor ema, but not Epg5, on lysosomes. After fusion, Arl8 mediates the plus-end transport of autolysosomes, while Rab39 promotes dynein-regulated minus-end directed transport. Thus, the motility of pre-fusion and post-fusion organelles is differently regulated: pre-fusion organelles generally move towards the MTOC, while post-fusion organelles exhibit bidirectional motility. This spatial regulation ensures proper fusion rates and degradation efficiency.

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  • Change to Emergency Contingency Surcharge Indian Subcontinent to North Europe & Mediterranean (E3W & E4W)

    We would like to inform you of changes to the Emergency Contingency Surcharges (ECS) for Indian Subcontinent to North Europe & Mediterranean (E3W & E4W) trades, related to the ongoing situation in the Red Sea / Gulf of Aden. There will be changes in charges for the following route:

    • India, Pakistan, Sri Lanka, and Maldives to North Europe & Mediterranean

    The situation continues to cause industry-wide disruptions, including delays at ports. We are experiencing industry-wide equipment and capacity shortages, as well as long-term additional costs and strong demand from our customers.

    We know our customers are facing challenges too and we are continually reviewing our surcharges in this constantly evolving environment. Due to market developments, changes will take effect from the Price Calculation Date (PCD) 1 November 2025. You can see the changes to the ECS surcharge here.

    All surcharge changes are subject to any required regulatory approvals and notice periods, after which the surcharge will apply. You will see any relevant surcharges on your latest invoices, and we will keep you updated of any further changes.

    For the latest information, including on changes to surcharges, please visit our dedicated Red Sea / Gulf of Aden page on Maersk.com. We urge you to regularly check the surcharge pages to remain informed on changes regarding surcharges.

    If you have any further questions, please contact your local Maersk office or Maersk representative. They are standing by to help. Thank you for your understanding during this time. We remain committed to supporting you and your business with your supply chain needs.

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  • investors look ahead to interest rate decision

    investors look ahead to interest rate decision

    U.S. Treasury yields moved lower on Tuesday as investors looked ahead to the Federal Reserve’s interest rate decision.

    At 7:10 a.m. ET, the benchmark 10-year Treasury yield was down one basis point to 3.981%, while the 2-year Treasury note yield was less than a basis point lower at 3.492%. The 30-year bond yield fell more than 1 basis points to 4.554%.

    One basis point equals 0.01% (1/100th of 1%) and yields and prices move inversely to one another.

    Investors are anticipating the start of the two-day Fed meeting on Tuesday, as policymakers are widely expected to cut rates.

    Traders are pricing in a nearly 98% chance that the overnight fed funds rate will fall to a range of 3.75% to 4.00% down from a range of 4.00% to 4.25% today, per the CME FedWatch Tool.

    Fed Chair Jerome Powell’s speech which follows the interest rate decision announcement, will also be closely watched for clues about whether the central bank will cut again at its final meeting in December.

    Meanwhile, as the U.S. government shutdown continues, investors are still dealing with an economic data blackout.

    U.S. President Donald Trump and Chinese President Xi Jinping are due to meet on Thursday in South Korea. As both countries have agreed on a framework for a potential trade deal, investors are expecting that trade tensions will ease.

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  • Cygnet Energy to acquire Kiwetinohk in $1 billion deal – Reuters

    1. Cygnet Energy to acquire Kiwetinohk in $1 billion deal  Reuters
    2. Cygnet Energy Enters into Agreement to Acquire Kiwetinohk Energy Corp.  Newswire Canada
    3. Kiwetinohk announces a cash sale for $24.75 per share under Arrangement Agreement with Cygnet Energy  MarketScreener
    4. Kiwetinohk Announces a Cash Sale for $24.75 Per Share under Arrangement Agreement with Cygnet Energy Ltd.  The Globe and Mail

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  • Barcode scanner maker Zebra forecasts upbeat Q4 on resilient demand, lower tariffs – Reuters

    1. Barcode scanner maker Zebra forecasts upbeat Q4 on resilient demand, lower tariffs  Reuters
    2. Zebra Technologies to Report Q3 Earnings: What’s in the Offing?  Yahoo Finance
    3. Zebra Technologies Announces Third-Quarter 2025 Results  The AI Journal
    4. Zebra Technologies Tops Q3 Views, Guides Above Estimates  Investor’s Business Daily
    5. Zebra earnings beat by $0.15, revenue topped estimates  Investing.com

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  • Hydrogen Europe

    Hydrogen Europe

    The entire west coast of Finland has been officially designated as a hydrogen valley by the European Union. The newly established BotH₂nia Hydrogen Valley encompasses the NUTS3 regions of Southwest Finland, Satakunta, Pirkanmaa, Ostrobothnia, Central Ostrobothnia, North Ostrobothnia, and Sea Lapland.

    The designation comes from the EU’s Clean Hydrogen Partnership programme, recognising the region’s potential to produce substantial volumes of hydrogen using affordable renewable electricity. Currently, the valley generates more than two-thirds of Finland’s wind power, contributing to some of the lowest electricity prices in Europe. By 2030, the region is expected to produce nearly 300,000 metric tonnes of clean hydrogen annually, primarily through electrolysis powered by renewable energy.

    BotH₂nia Hydrogen Valley is projected to attract over €3 billion in investments by 2030, positioning it as a key player in Europe’s clean hydrogen and e-fuel production. The region is home to a dynamic ecosystem of innovative companies, with 17 distinct hydrogen value chains already identified. Global leaders such as ABB, Danfoss, Hitachi Energy, and Wärtsilä, alongside smaller tech firms and start-ups, are collectively investing €350 million annually in research and development, driving innovation and scalability.

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