Category: 3. Business

  • UK can create 5,400 jobs if it stops plastic waste exports, report finds | Plastics

    UK can create 5,400 jobs if it stops plastic waste exports, report finds | Plastics

    The UK could end its reliance on exporting plastic waste by 2030 to support the creation of 5,400 new jobs and take responsibility for the environmental impact of its waste, according to research.

    The report said up to 15 new recycling facilities could be built by the end of the decade, attracting more than £800m of private investment. The increase in capacity would help generate almost £900m of economic value every year; providing at least £100m of new tax revenues annually.

    The report by Hybrid Economics comes as Britain’s plastic exports rose by 5% in 2024 to nearly 600,000 tonnes of waste.

    Exporting plastic creates environmental problems for many countries that receive it, as they do not have the ability to recycle it. It also, the report argues, removes valuable feedstock for a British recycling industry.

    Campaigners want the loophole that makes it cheaper to export plastic waste rather than recycle it in the UK, closed.

    Exports have soared in the first part of this year to Indonesia in particular – a country struggling with an environmental crisis from plastic pollution – amounting to more than 24,000 tonnes.

    The report said that by exporting the unprocessed plastic waste it produces, the UK is evading its responsibility to deal with its own waste and was denying itself an economic opportunity.

    The Guardian revealed last month that, in the past two years, 21 plastic recycling and processing factories across the UK have shut down owing to the scale of exports, the cheap price of virgin plastic and an influx of cheap products from Asia.

    Neville Hill, partner at Hybrid Economics, which produced the report, said the UK was only using half of its potential for recycling plastic waste. He said: “Ending exports of unprocessed plastic packaging waste by 2030 would allow the UK to take control of its environmental responsibilities and seize a clear economic opportunity.

    “Our analysis shows the sector can expand significantly with no call on public funds, provided government sets the right framework.”

    The way payments are made up at present incentivises the export of plastic waste, rather than encouraging businesses to keep it in the UK to be recycled.

    James McLeary, the managing director of Biffa Polymers, which commissioned the report, said the company had recycled 10bn plastic HDPE milk bottles in the last 20 years. He described this as a circular economy success story.

    “The lesson is simple. When the right conditions are in place, UK recycling grows, investment follows and the environmental and economic benefits build year after year. The UK can replicate that success across all plastic packaging and take responsibility for processing its own waste onshore.”

    The report is calling for an increase in the plastic packaging tax, which is imposed on producers who fail to include at least 30% of recycled plastic in their products, to 50% and a total phasing out of exports of unprocessed plastic packaging waste.

    Continue Reading

  • Benoy appointed lead urban designer and commercial strategist for SAR 1 billion Riyadh East scheme

    Benoy appointed lead urban designer and commercial strategist for SAR 1 billion Riyadh East scheme

    Dar wa Emaar has appointed Benoy as lead urban designer and commercial strategist for Riyadh East, a SAR 1 billion, mixed-use neighbourhood spanning 116 hectares on the eastern edge of Riyadh. 

    The partnership was marked by the signing of a strategic agreement between Dar wa Emaar and Benoy last week at Cityscape Global.

    Developed by Benoy’s Commercial Strategy and Masterplanning & Urban Design teams, Riyadh East offers a welcoming new neighbourhood shaped around contemporary living and generous climate-responsive green corridors that bring nature into daily life. Its mix of homes, community facilities, learning spaces, pocket parks and neighbourhood hubs creates a commercially viable, walkable community for families and young professionals alike.

    Ruchi Chakravarty, Director, Masterplanning & Urban Design, said: Riyadh East sets a bold new standard for Saudi urbanism, where sustainability and social value lead the design. It represents an ambitious yet grounded vision that elevates Riyadh’s long-term growth and defines the future of high-quality neighbourhoods in the Kingdom.”

    Amr Elfeky, Executive Director, Development & Investment at Dar wa Emaar commented: Our partnership with Benoy marks a pivotal step in shaping Riyadh East into a next-generation community. Benoy’s global design expertise, coupled with their deep understanding of how people live and interact with spaces, aligns seamlessly with our vision for a human-centered, future-ready masterplan. Together, we are setting a new benchmark for community development in the Kingdom.”

    Strategically positioned along the Riyadh – Dammam corridor, Riyadh East will be anchored by a curated mix of exciting new amenities, all designed to welcome passing visitors and drive commercial investment. 

    Andrew McVicker, Director, Commercial Strategy, said: Riyadh East will redefine dynamic, contemporary community living. Our approach ensures a vibrant, multi-use destination designed for long-term economic sustainability and enduring value.”

    A continuous green spine forms the ecological and social backbone of the district, promoting active mobility, biodiversity, and climate resilience while uniting the community through a shared landscape. District neighbourhoods are conceived as walkable clusters, each with its own architectural and landscape identity. This mosaic approach supports inclusivity, housing diversity, and flexible, phased growth, allowing the district to evolve with lasting character.

    Aligned with the Mostadam framework and the ambitions of Saudi Vision 2030, Benoy’s vision for Riyadh East demonstrates how a commitment to integrated design and commercial insight can deliver a district that is both highly liveable and economically robust. 

    Continue Reading

  • NIO Inc. Reports Unaudited Third Quarter 2025 Financial Results – NIO – Home

    1. NIO Inc. Reports Unaudited Third Quarter 2025 Financial Results  NIO – Home
    2. NIO’s Q3 revenue climbs 16.7% to $3.1B  breakingthenews.net
    3. Nio Narrows Losses in Q3, Cuts Q4 Guidance Risking Profitability Target  eletric-vehicles.com
    4. (NIO) Nio Expects Q4 Total Revenue Range 32.76B Renminbi – 34.04B Renminbi, vs. FactSet Est of 35.23B Renminbi  MarketScreener
    5. Niu Technologies Reports Robust Q3 2025 Financial Results with Strong Growth in China  TipRanks

    Continue Reading

  • European shares muted as markets turn cautious ahead of US data – Reuters

    1. European shares muted as markets turn cautious ahead of US data  Reuters
    2. European stocks open slightly higher, tracking Wall Street rebound  CNBC
    3. DE40: European tech and defence stocks sell-off  XTB.com
    4. European Shares Seen Lower As Investors Await US Data  Nasdaq
    5. European Stocks Set to Drop Following Wall Street Reversal  Bloomberg.com

    Continue Reading

  • COP30: African Development Bank Group Backs Increased Access to Climate Finance for Electricity Grids and Energy Storage – African Development Bank Group

    1. COP30: African Development Bank Group Backs Increased Access to Climate Finance for Electricity Grids and Energy Storage  African Development Bank Group
    2. Africa secures $57mln for a just energy transition, Mission 300  ZAWYA
    3. AfDB Secures Nearly €50 Million For African Energy Access At COP30  News Ghana
    4. COP30: AfDB’s SEFA mobilises nearly EUR50 million in new commitments for just energy transition and Mission 300  CediRates

    Continue Reading

  • BASF Coatings sets innovation benchmark with Lean Lab in Wuerzburg

    • New laboratory concept drives innovative, customer-centric product development
    • Optimized material flow delivers high CO₂ savings  

    With a new laboratory at its site in Wuerzburg, Germany, BASF Coatings reinforces its position as a pioneer in digitalization, occupational safety, efficiency, and sustainability. The innovative “Lean Lab” concept focuses on developing and producing waterborne basecoats for customers in the European automotive industry.  

    “The Lean Lab in Wuerzburg is part of our global rollout. With this infrastructure, we are laying the foundation for modern, digitalized, and flexible product development, reaffirming our commitment to driving innovation and sustainability consistently across all regions,” emphasizes Dr. Ralf Otte, Vice President, Global Technology, Automotive OEM Coatings at BASF Coatings. “I am very proud of our project team, who implemented the concept with great commitment within the planned timeframe.” 

    The Lean Lab concept is currently being introduced at additional BASF Coatings sites worldwide and adapted to specific local requirements. The strategy is based on clear specialization: wet work is handled in the process laboratory, the product laboratory focuses on intensive customer support and continuous product optimization, and the laboratory services organize the provision of raw materials and supplies. Accordingly, work is divided into three areas: process laboratory, product laboratory, and laboratory services.  

    All workstations are ergonomically designed and equipped with state-of-the-art IT infrastructure. Every process is fully digitally recorded and efficiency oriented. The laboratory’s central location, close to production, enables close interdisciplinary collaboration and ensures rapid implementation of innovations. 

    The Lean Lab already meets future EU requirements for raw material classification and occupational safety. It drives digitization and efficiency in product development, with a strong focus on sustainability: optimized material flow, direct logistics connections, and centralized space save 25.1 tons of CO₂ annually. Resource utilization is further improved through consumption-based material supply. 

    Customized laboratory software and an RFID-based warehouse system in the new laboratory ensure transparent processes and automated data collection. Warehouse management, including raw material ordering, is also fully digital. A modern working café fosters creativity, teamwork, and employee well-being. 

    The BASF Coatings team in Wuerzburg develops and produces waterborne basecoats for automotive OEM customers around the globe. The new laboratory concept further strengthens the site’s role as a key hub and attractive employer in the region. 
     

    Continue Reading

  • policy progress, challenges, and pathways forward – CEPS

    policy progress, challenges, and pathways forward – CEPS


    Gender equality and gender mainstreaming have been established as central priorities within the European Union’s current Framework Programme for Research and Innovation (R&I), Horizon Europe (2021–27). The European Commission has demonstrated a strong commitment to promoting gender equality through measures such as mandatory Gender Equality Plans (GEPs) and the systemic integration of the gender perspective in research. However, despite progress, available data indicate that advancements remain slow, underscoring the need for more robust action by the EU to achieve meaningful equality in this field. 

    Drawing on existing literature and data, this paper introduces a new theoretical framework for analysing the integration of gender equality and gender mainstreaming in Horizon Europe across three interrelated dimensions: structural, epistemic and substantive. It conceptualises gender equality in R&I as a circle, where progress in one dimension can mutually reinforce advancement in the others. The paper further identifies emerging themes and priority areas for the next Framework Programme, addressing persistent challenges in gender equality, and proposes seven targeted policy actions. 

    Implementing these measures would enhance the EU’s capacity to mainstream gender in research, strengthen its leadership in promoting gender equality, and its position as a global example for gender-responsive R&I. 

     

    To read all publications in the ‘EU R&I and Health Policy’ series, please click here.

    Continue Reading

  • Yamanaka S. Pluripotent stem cell-based cell therapy-promise and challenges. Cell Stem Cell. 2020;27(4):523–31.

    Google Scholar 

  • Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022;7(1):272.

    Google Scholar 

  • Galipeau J, Sensébé L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824–33.

    Google Scholar 

  • Kabat M, Bobkov I, Kumar S, Grumet M. Trends in mesenchymal stem cell clinical trials 2004-2018: is efficacy optimal in a narrow dose range? Stem Cells Transl Med. 2020;9(1):17–27. https://doi.org/10.1002/sctm.19-0202.

    Google Scholar 

  • Yin JQ, Zhu J, Ankrum JA. Manufacturing of primed mesenchymal stromal cells for therapy. Nat Biomed Eng. 2019;3(2):90–104.

    Google Scholar 

  • Taherian Fard A, Leeson HC, Aguado J, Pietrogrande G, Power D, Gómez-Inclán C, et al. Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. Geroscience. 2024;46(1):999–1015. https://doi.org/10.1007/s11357-023-00829-y.

    Google Scholar 

  • Miclau K, Hambright WS, Huard J, Stoddart MJ, Bahney CS. Cellular expansion of MSCs: shifting the regenerative potential. Aging Cell. 2023;22(1):e13759. https://doi.org/10.1111/acel.13759.

    Google Scholar 

  • Huang Y, Li Q, Zhang K, Hu M, Wang Y, Du L, et al. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019;10(5):368.

    Google Scholar 

  • López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243–78.

    Google Scholar 

  • Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, et al. NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation. Aging Cell. 2022;21(2):e13551. https://doi.org/10.1111/acel.13551.

    Google Scholar 

  • Weng Z, Wang Y, Ouchi T, Liu H, Qiao X, Wu C, et al. Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies. Stem Cells Transl Med. 2022;11(4):356–71.

    Google Scholar 

  • Weber L, Lee BS, Imboden S, Hsieh CJ, Lin NYC. Phenotyping senescent mesenchymal stromal cells using AI image translation. Curr Res Biotechnol. 2023;5:100120. https://doi.org/10.1016/j.crbiot.2023.100120.

    Google Scholar 

  • Li X, Luo X, He Y, Xu K, Ding Y, Gao P, et al. Micronano titanium accelerates mesenchymal stem cells aging through the activation of senescence-associated secretory phenotype. ACS Nano. 2023;17(22):22885–900.

    Google Scholar 

  • Brunet A, Goodell MA, Rando TA. Ageing and rejuvenation of tissue stem cells and their niches. Nat Rev Mol Cell Biol. 2023;24:45–62.

    Google Scholar 

  • Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, et al. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013;13(2):246–54.

    Google Scholar 

  • Jiao H, Walczak BE, Lee MS, Lemieux ME, Li WJ. GATA6 regulates aging of human mesenchymal stem/stromal cells. Stem Cells. 2021;39(1):62–77.

    Google Scholar 

  • Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab. 2021;3(12):1706–26.

    Google Scholar 

  • Zhang C, Han X, Liu J, Chen L, Lei Y, Chen K, et al. Single-cell transcriptomic analysis reveals the cellular heterogeneity of mesenchymal stem cells. Genomics Proteomics Bioinformatics. 2022;20(1):70–86.

    Google Scholar 

  • Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature. 2018;562(7728):578–82.

    Google Scholar 

  • Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, et al. Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy. 2022;24(5):456–72.

    Google Scholar 

  • Ross EA, Turner LA, Donnelly H, Saeed A, Tsimbouri MP, Burgess KV, et al. Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells. Nat Commun. 2023;14(1):753.

    Google Scholar 

  • Yuan H, Xu Y, Luo Y, Zhang JR, Zhu XX, Xiao JH. Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells. Aging Cell. 2022;21(9):e13686. https://doi.org/10.1111/acel.13686.

    Google Scholar 

  • Xu Y, Yuan H, Luo Y, Zhao YJ, Xiao JH. Ganoderic acid D protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK/NRF2 signaling pathway. Oxid Med Cell Longev. 2020;2020:8291413. https://doi.org/10.1155/2020/8291413.

    Google Scholar 

  • Wong PF, Dharmani M, Ramasamy TS. Senotherapeutics for mesenchymal stem cell senescence and rejuvenation. Drug Discov Today. 2023;28(1):103424. https://doi.org/10.1016/j.drudis.2022.103424.

    Google Scholar 

  • Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28:1556–68.

    Google Scholar 

  • Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun. 2018;9(1):5435.

    Google Scholar 

  • Chelyapov N, Nguyen TT, Gonzalez R. Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs. Biochem Biophys Rep. 2022;32:101380. https://doi.org/10.1016/j.bbrep.2022.101380.

    Google Scholar 

  • Tang X, Deng B, Zang A, He X, Zhou Y, Wang D, et al. Characterization of age-related immune features after autologous NK cell infusion: protocol for an open-label and randomized controlled trial. Front Immunol. 2022;13:940577. https://doi.org/10.3389/fimmu.2022.940577.

    Google Scholar 

  • Bayik D, Lathia JD. Cancer stem cell-immune cell crosstalk in tumour progression. Nat Rev Cancer. 2021;21(8):526–36.

    Google Scholar 

  • Bobyleva P, Gornostaeva A, Andreeva E, Ezdakova M, Gogiya B, Buravkova L. Reciprocal modulation of cell functions upon direct interaction of adipose mesenchymal stromal and activated immune cells. Cell Biochem Funct. 2019;37(4):228–38.

    Google Scholar 

  • Valencic E, Loganes C, Cesana S, Piscianz E, Gaipa G, Biagi E, et al. Inhibition of mesenchymal stromal cells by pre-activated lymphocytes and their culture media. Stem Cell Res Ther. 2014;5(1):3.

    Google Scholar 

  • Bobyleva PI, Andreeva ER, Gornostaeva AN, Buravkova LB. Tissue-related hypoxia attenuates proinflammatory effects of allogeneic PBMCs on adipose-derived stromal cells in vitro. Stem Cells Int. 2016;2016(1):4726267. https://doi.org/10.1155/2016/4726267.

    Google Scholar 

  • Al-Azab M, Safi M, Idiiatullina E, Al-Shaebi F, Zaky MY. Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting. Cell Mol Biol Lett. 2022;27(1):69.

    Google Scholar 

  • Olsen Saraiva Camara N, Lepique AP, Basso AS. Lymphocyte differentiation and effector functions. Clin Dev Immunol. 2012;2012:510603.

    Google Scholar 

  • Van der Meide PH, Schellekens H. Cytokines and the immune response. Biotherapy. 1996;8(3–4):243–9. https://doi.org/10.1007/BF01877210.

    Google Scholar 

  • Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature. 2009;458:1127–30.

    Google Scholar 

  • Rodríguez JA. Interplay between nuclear transport and ubiquitin/SUMO modifications in the regulation of cancer-related proteins. Semin Cancer Biol. 2014;27:11–9.

    Google Scholar 

  • Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018;25(1):190–203.

    Google Scholar 

  • Chang HM, Yeh ETH. SUMO: from bench to bedside. Physiol Rev. 2020;100(4):1599–619.

    Google Scholar 

  • Burczynski ME, Peterson RL, Twine NC, Zuberek KA, Brodeur BJ, Casciotti L, et al. Molecular classification of Crohn’s disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. J Mol Diagn. 2006;8(1):51–61.

    Google Scholar 

  • Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109(4):E177-86.

    Google Scholar 

  • Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell. 2014;31(6):722–33.

    Google Scholar 

  • Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, et al. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science. 2022;378(6616):192–201.

    Google Scholar 

  • Prata LGPL, Ovsyannikova IG, Tchkonia T, Kirkland JL. Senescent cell clearance by the immune system: emerging therapeutic opportunities. Semin Immunol. 2018;40:101275. https://doi.org/10.1016/j.smim.2019.04.003.

    Google Scholar 

  • Carvalho AÉS, Sousa MRR, Alencar-Silva T, Carvalho JL, Saldanha-Araujo F. Mesenchymal stem cells immunomodulation: the road to IFN-γ licensing and the path ahead. Cytokine Growth Factor Rev. 2019;47:32–42.

    Google Scholar 

  • Mabuchi Y, Okawara C, Méndez-Ferrer S, Akazawa C. Cellular heterogeneity of mesenchymal stem/stromal cells in the bone marrow. Front Cell Dev Biol. 2021;9:689366. https://doi.org/10.3389/fcell.2021.689366.

    Google Scholar 

  • Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, et al. Cellular senescence is immunogenic and promotes antitumor immunity. Cancer Discov. 2023;13(2):410–31.

    Google Scholar 

  • Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169(1):132-147.e16.

    Google Scholar 

  • Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, et al. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nat Commun. 2019;10(1):2387.

    Google Scholar 

  • Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, et al. Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes. Nature. 2022;611(7935):358–64.

    Google Scholar 

  • Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012;483(7391):598–602.

    Google Scholar 

  • Naik S, Larsen SB, Gomez NC, Alaverdyan K, Sendoel A, Yuan S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550(7677):475–80.

    Google Scholar 

  • Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, et al. Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories. Science. 2021;374(6571):eabh2444.

    Google Scholar 

  • Lanna A, Vaz B, D’Ambra C, Valvo S, Vuotto C, Chiurchiù V, et al. An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory. Nat Cell Biol. 2022;24(10):1461–74.

    Google Scholar 

  • Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574(7779):553–8.

    Google Scholar 

  • Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc Natl Acad Sci U S A. 2016;113:E5024–33.

    Google Scholar 

  • Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, et al. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016;18(7):777–89.

    Google Scholar 

  • Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït-Hamou N, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011;25(21):2248–53.

    Google Scholar 

  • Li W, Liu Q, Shi J, Xu X, Xu J. The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment. Front Immunol. 2023;14:1074863.

    Google Scholar 

  • Magne B, Dedier M, Nivet M, Coulomb B, Banzet S, Lataillade JJ, et al. IL-1β-primed mesenchymal stromal cells improve epidermal substitute engraftment and wound healing via matrix metalloproteinases and transforming growth factor-β1. J Invest Dermatol. 2020;140(3):688-698.e21.

    Google Scholar 

  • Renner L, von Soosten D, Sipka A, Döll S, Beineke A, Schuberth HJ, et al. Effect of conjugated linoleic acid on proliferation and cytokine expression of bovine peripheral blood mononuclear cells and splenocytes ex vivo. Arch Anim Nutr. 2012;66(2):73–85.

    Google Scholar 

  • Dagur PK, McCoy JP Jr. Collection, storage, and preparation of human blood cells. Curr Protoc Cytom. 2015;73:5.1.1-5.1.16.

    Google Scholar 

  • Fu YP, Yuan H, Xu Y, Liu RM, Luo Y, Xiao JH. Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings. Phytomedicine. 2022;99:154006.

    Google Scholar 

  • Wang AT, Zhang QF, Wang NX, Yu CY, Liu RM, Luo Y, et al. Cocktail of hyaluronic acid and human amniotic mesenchymal cells effectively repairs cartilage injuries in sodium iodoacetate-induced osteoarthritis rats. Front Bioeng Biotechnol. 2020;8:87.

    Google Scholar 

  • Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. [RNA-Seq]. NCBI, GEO. 2025. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307002.

  • Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. [RNA-Seq]. NCBI, GEO. 2025. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307003.

  • Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. ProteomeXchange. 2025. Accession: PXD066147, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD066147.

Continue Reading

  • Lower Costs, Greater Efficiency: Adami Trasporti Relies on Continental Tires

    Lower Costs, Greater Efficiency: Adami Trasporti Relies on Continental Tires

    The family-owned company Adami Trasporti, which now has 280 employees, has specialized in food transport for more than four generations. The fleet consists of modern tanks and tank containers designed for the transport of liquid food products. “With one of the most modern truck and trailer fleets in Europe, we guarantee our customers the highest quality standards and maximum service flexibility,” says Stefano Adami. The 200 vehicles operate from Verona and three other strategic locations in Castelmassa, Italy; Bratislava, Slovakia; and Beilngries, Germany – along the European and national north-south and east-west transport axes. “We transport liquids such as fruit juices, glucose, wine, milk, chocolate, and cooking oil. Everything is always done in compliance with the highest food safety standards,” says the freight forwarder.

    Continue Reading

  • Siemens showcases the future of autonomous production at SPS 2025 | Press | Company

    Siemens showcases the future of autonomous production at SPS 2025 | Press | Company

    [{“nid”:0,”name”:”Products & Solutions”,”tid”:0,”url_str”:”https://www.siemens.com/global/en/products.html”,”alias”:”https://www.siemens.com/global/en/products.html”,”level”:1,”image”:{“fid”:false,”furl”:””},”options”:{“menu_icon”:{“fid”:false},”external”:true},”depth”:1,”parent”:false,”children”:[]},{“nid”:0,”name”:”Industries”,”tid”:1,”url_str”:”https://xcelerator.siemens.com/global/en/industries.html”,”alias”:”https://xcelerator.siemens.com/global/en/industries.html”,”level”:1,”image”:{“fid”:false,”furl”:””},”options”:{“menu_icon”:{“fid”:false},”external”:true},”depth”:1,”parent”:false,”children”:[]},{“nid”:0,”name”:”Company”,”tid”:2,”url_str”:”https://www.siemens.com/global/en/company.html”,”alias”:”https://www.siemens.com/global/en/company.html”,”level”:1,”image”:{“fid”:false,”furl”:””},”options”:{“menu_icon”:{“fid”:false},”external”:true},”depth”:1,”parent”:false,”children”:[]}]

    Continue Reading