Category: 3. Business

  • Mass balance shift for UK’s plastic packaging tax

    Mass balance shift for UK’s plastic packaging tax

    The UK government confirmed it would be offering businesses the opportunity to use a mass balance approach (MBA) to measuring recycled plastic from April 2027, after consultations with the industry on revamping the way recycled content was measured.

    PPT is not charged on plastic packaging components containing more than 30% recycled plastic. Chemically recycled plastic has always been eligible for this exemption, however it can be hard to determine the exact amount of chemically recycled material in a specific output.

    Mass balance is a model used by industries to track materials through their chain of custody through the value process and allows recycled or sustainable inputs mixed with new materials during the process to be allocated to particular outputs.

    Since the tax was introduced in 2022, advancements in chemical recycling processes make it easier to recycle previously harder to deal with plastics. This new approach will enable businesses to take better advantage of these recycled plastics.

    Abigail McGregor, a tax expert with Pinsent Masons, said the move to making a mass balance approach available had been anticipated since a 2023 consultation exercise and the government’s response to it at Budget 2024.

    “The introduction of mass balance approach to achieve the 30% recycled threshold to claim exemption from PPT will be welcome to many businesses,” she said.

    “The requirement for recognised commercial certification is not surprising in the context of HMRC grappling with challenges over the evidential requirements for recycled plastic coming from overseas.”

    UK manufacturers and importers of plastic packaging will need to prove the supply chain for recycled material in their plastics is covered by an appropriate, PPT MBA standard-compliant certificate in order to qualify for the plastic tax relief. The government has committed to publishing a consultation in early 2026 on the introduction of this mandatory certification.

    Alongside the shift to enable MBA, the government will no longer allow the inclusion of pre-consumer waste as a source of recycled plastic in the 30%-plus recycled content needed for PTT exemption.

    Pre-consumer waste – which includes defective products and leftover scraps – can still be included in the recycling process but, the government said, the move to exclude it from tax relief in the switch to mass balance would provide an economic incentive to better recycling processes.

    “Some businesses will feel the impact of no longer being able to classify pre-consumer plastic – such as plastic that has come off their own manufacturing line, repelletised then recycled into the manufacturing line again – as recycled,” warned McGregor.

    “While the overall tax take is not expected to change as a result of the introduction of MBA, it may be that the burden of the liability shifts from one group of taxpayers – those currently unable to claim exemption due to the absence of the mass balance approach – to those who will no longer be able to use pre-consumer plastic to claim exemption.”

    The government also announced that the rate of PPT from 1 April 2026 will increase in line with CPI inflation as part of the 2025 UK Budget.

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  • Services PMI® at 52.6%; November 2025 ISM® Services PMI® Report

    Services PMI® at 52.6%; November 2025 ISM® Services PMI® Report

    Business Activity Index at 54.5%; New Orders Index at 52.9%; Employment Index at 48.9%; Supplier Deliveries Index at 54.1%

    TEMPE, Ariz., Dec. 3, 2025 /PRNewswire/ — Economic activity in the services sector continued to expand in November, say the nation’s purchasing and supply executives in the latest ISM® Services PMI® Report. The Services PMI® registered at 52.6 percent and is in expansion territory for the ninth time in 2025.

    The report was issued today by Steve Miller, CPSM, CSCP, Chair of the Institute for Supply Management® (ISM®) Services Business Survey Committee: “In November, the Services PMI® registered a reading of 52.6 percent, 0.2 percentage point higher than the October figure of 52.4 percent. The Business Activity Index continued in expansion territory in November, registering 54.5 percent, 0.2 percentage point higher than the reading of 54.3 percent recorded in October. The New Orders Index also remained in expansion in November, with a reading of 52.9 percent, 3.3 percentage points below October’s figure of 56.2 percent but 0.9 percentage point above its 12-month average of 51.7 percent. The Employment Index contracted for the sixth month in a row with a reading of 48.9 percent, a 0.7-percentage point improvement from the 48.2 percent recorded in October — the fourth consecutive monthly increase since a reading of 46.4 percent in July.

    “The Supplier Deliveries Index registered 54.1 percent, 3.3 percentage points higher than the 50.8 percent recorded in October and 2.2 percentage points above its 12-month average of 51.9 percent. This is the 12th consecutive month that the index has been in expansion territory, indicating slower supplier delivery performance. (Supplier Deliveries is the only ISM® PMI® Reports index that is inversed; a reading of above 50 percent indicates slower deliveries, which is typical as the economy improves and customer demand increases.)

    “The Prices Index registered 65.4 percent in November, its lowest reading since hitting 65.1 percent in April 2025. The November figure was a 4.6-percentage point drop from October’s reading of 70 percent. The index has exceeded 60 percent for 12 straight months.

    “The Inventories Index registered 53.4 percent in November, an increase of 3.9 percentage points from October’s figure of 49.5 percent, a return to expansion after two months in contraction territory. The Inventory Sentiment Index expanded for the 31st consecutive month, registering 54.8 percent, down 0.7 percentage point from October’s figure of 55.5 percent. The Backlog of Orders Index was in contraction territory for the ninth month in a row, registering 49.1 percent in November, an 8.3-percentage point increase from the October figure of 40.8 percent, and 3.8 percentage points above its 12-month average of 45.3 percent.

    “Twelve industries reported growth in November, one more than in October, while the number reporting contraction decreased from six to five. The November Services PMI® reading of 52.6 percent is 0.9 percentage point above the 12-month average of 51.7 percent. However, the 12-month average continues at its lowest level since August 2024 (51.7 percent) for the second month in a row, and the second lowest since June 2010 (51.4 percent).”

    Miller continues, “November’s Services PMI® is a continuation of a downward trend (as noted in the October report) of more than 10 percentage points in the 12-month average since February 2022, when it was 62.6 percent. The continued expansion in both the Business Activity and New Orders indexes in November, and the highest Backlog of Orders index reading since February 2025 are positive signs of an emerging recovery for the services sector. On the downside, tariffs and the government shutdown continue to be noted by survey respondents as impacting both demand and costs. The Employment index reading of 48.9 percent, while still in contraction, is its highest reading since it registered 50.7 percent in May 2025. The highest Supplier Deliveries index figure (54.1 percent) since October 2024 — a reading in expansion indicates slower deliveries by suppliers — was likely due to air traffic disruptions from the government shutdown and customs impacts related to changing tariffs. The tragic UPS plane crash on November 4 is also a sobering reminder, especially with the coming holidays that rely on timely deliveries, of the risks that logistics providers take every day on our roads, waterways and skies to ensure that supply chains operate smoothly.”

    INDUSTRY PERFORMANCE

    The 12 services industries reporting growth in November — listed in order — are: Retail Trade; Arts, Entertainment & Recreation; Accommodation & Food Services; Wholesale Trade; Health Care & Social Assistance; Educational Services; Public Administration; Agriculture, Forestry, Fishing & Hunting; Finance & Insurance; Information; Professional, Scientific & Technical Services; and Utilities. The five industries reporting a contraction in the month of November are: Construction; Real Estate, Rental & Leasing; Mining; Management of Companies & Support Services; and Transportation & Warehousing.

    WHAT RESPONDENTS ARE SAYING

    • “Suppliers are very inconsistent on how they are planning and executing pricing related to tariffs. Overall uncertainty on how to source and how much to source is as high as during the coronavirus pandemic era.” [Accommodation & Food Services]
    • “Residential home sales continue to be hampered by mortgage rates. Most of the industry is describing their slowdown as an intentional pause, while suppliers and labor are looking at cutting margins. To maintain build volume, subcontractors are tightening their belts.” [Construction]
    • “Increased activity due to year end project push.” [Finance & Insurance]
    • “Patient volumes appear to be leveling off a bit, providing teams a chance to catch their breath. Supply chains are operating surprisingly well, as measured by notably higher back-order and fill-rate performance. Labor remains a strong performer as well; staffing levels remain high and there is less demand for travel labor altogether. Cost of goods remains higher but there are pockets of softening beginning to appear. Forecast remains optimistic.” [Health Care & Social Assistance]
    • “Business still slow due to tariffs.” [Information]
    • “With the end of the federal government shutdown, we have resumed normal operations. However, we are cautious that there may be another shutdown at the end of January.” [Management of Companies & Support Services]
    • “Tariff uncertainty continues to add complexity to purchasing, and economic conditions remain mixed, with some indicators pointing to good prospects and others to worrying ones.” [Real Estate, Rental & Leasing]
    • “Business continues to be strong, driven by customer traffic. Pricing stable.” [Retail Trade]
    • “Business is ramping down for the end of the year — an overall great year.” [Utilities]
    • “We are anticipating demand to be consistent with what we have seen in 2025 thus far. Affordability continues to be a problem for an entire generation of buyers. We expect margins to erode as competitors fight for business. Lumber production is set to be reduced significantly, so prices should increase in 2026.” [Wholesale Trade]

    ISM® SERVICES SURVEY RESULTS AT A GLANCE

    COMPARISON OF ISM® SERVICES AND ISM® MANUFACTURING SURVEYS

    NOVEMBER 2025

    Index

     Services PMI®

    Manufacturing PMI®

    Series Index

    Nov

    Series Index

    Oct

    Percent
    Point
    Change

     

     

    Direction

     

    Rate of
    Change

     

    Trend*

    (Months)

    Series Index

    Nov

    Series Index

    Oct

    Percent
    Point
    Change

    Services PMI®

    52.6

    52.4

    +0.2

    Growing

    Faster

    2

    48.2

    48.7

    -0.5

    Business Activity/

    Production

    54.5

    54.3

    +0.2

    Growing

    Faster

    2

    51.4

    48.2

    +3.2

    New Orders

    52.9

    56.2

    -3.3

    Growing

    Slower

    6

    47.4

    49.4

    -2.0

    Employment

    48.9

    48.2

    +0.7

    Contracting

    Slower

    6

    44.0

    46.0

    -2.0

    Supplier Deliveries

    54.1

    50.8

    +3.3

    Slowing

    Faster

    12

    49.3

    54.2

    -4.9

    Inventories

    53.4

    49.5

    +3.9

    Growing

    From Contracting

    1

    48.9

    45.8

    +3.1

    Prices

    65.4

    70.0

    -4.6

    Increasing

    Slower

    102

    58.5

    58.0

    +0.5

    Backlog of Orders

    49.1

    40.8

    +8.3

    Contracting

    Slower

    9

    44.0

    47.9

    -3.9

    New Export Orders

    48.7

    47.8

    +0.9

    Contracting

    Slower

    5

    46.2

    44.5

    +1.7

    Imports

    48.9

    43.7

    +5.2

    Contracting

    Slower

    3

    48.9

    45.4

    +3.5

    Inventory Sentiment

    54.8

    55.5

    -0.7

    Too High

    Slower

    31

    N/A

    N/A

    N/A

    Customers’ Inventories

    N/A

    N/A

    N/A

    N/A

    N/A

    N/A

    44.7

    43.9

    +0.8

    OVERALL ECONOMY

    Growing

    Faster

    66


    Services Sector

    Growing

    Faster

    2


    ISM® Services PMI® Report data is seasonally adjusted for the Business Activity, New Orders, Employment and Prices indexes. ISM® Manufacturing PMI® Report data is seasonally adjusted for New Orders, Production, Employment and Inventories indexes.
    *Number of months moving in current direction.

    COMMODITIES REPORTED UP/DOWN IN PRICE, AND IN SHORT SUPPLY

    Commodities Up in Price
    Benefits; Copper Products (4); Electronic Components; Labor (4); Software Licensing (2); and Steel.

    Commodities Down in Price
    Cheese; Engineered Wood Products; Gasoline (9); and Lumber.

    Commodities in Short Supply
    Electrical Components; Labor; Steel; Transformers (2); and Wire and Cable.

    Note: The number of consecutive months the commodity is listed is indicated after each item.

    NOVEMBER 2025 SERVICES INDEX SUMMARIES

    Services PMI®
    In November, the Services PMI® registered 52.6 percent, a 0.2-percentage point increase compared to the October reading of 52.4 percent. A reading above 50 percent indicates the services sector economy is generally expanding; below 50 percent indicates it is generally contracting.

    A Services PMI® above 48.6 percent, over time, generally indicates an expansion of the overall economy. Therefore, the November Services PMI® indicates the overall economy is expanding for the 66th straight month. Miller says, “The past relationship between the Services PMI® and the overall economy indicates that the Services PMI® for November (52.6 percent) corresponds to a 1.3-percentage point increase in real gross domestic product (GDP) on an annualized basis.”

    SERVICES PMI® HISTORY

    Month

    Services PMI®

    Month

    Services PMI®

    Nov 2025

    52.6

    May 2025

    49.9

    Oct 2025

    52.4

    Apr 2025

    51.6

    Sep 2025

    50.0

    Mar 2025

    50.8

    Aug 2025

    52.0

    Feb 2025

    53.5

    Jul 2025

    50.1

    Jan 2025

    52.8

    Jun 2025

    50.8

    Dec 2024

    54.0

    Average for 12 months – 51.7

    High – 54.0

    Low – 49.9

    Business Activity
    ISM®‘s Business Activity Index continued in expansion in November; the reading of 54.5 percent is 0.2 percentage point higher than the 54.3 percent recorded in October. The index registered above 54 percent for the seventh time in 2025. Comments from respondents include: “Capital projects are at an all-time high” and “Government shutdown paused some projects due to permitting.”

    The 11 industries reporting an increase in business activity for the month of November — listed in order — are: Arts, Entertainment & Recreation; Retail Trade; Health Care & Social Assistance; Educational Services; Public Administration; Finance & Insurance; Wholesale Trade; Transportation & Warehousing; Professional, Scientific & Technical Services; Information; and Management of Companies & Support Services. The five industries reporting a decrease in business activity for the month of November are: Real Estate, Rental & Leasing; Other Services; Construction; Utilities; and Accommodation & Food Services.

    Business Activity

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    24.7

    58.4

    16.9

    54.5

    Oct 2025

    23.0

    61.7

    15.3

    54.3

    Sep 2025

    20.5

    64.4

    15.1

    49.9

    Aug 2025

    22.8

    63.0

    14.2

    55.0

    New Orders
    ISM®‘s New Orders Index registered 52.9 percent in November, 3.3 percentage points lower than the reading of 56.2 percent reported in October. The index has been in expansion territory in 33 of the last 35 months. Comments from respondents include: “Big pharma is spending at a faster pace than the first half of 2025” and “Customer uncertainty reducing ability to commit to new orders.”

    The 12 industries reporting an increase in new orders for the month of November — listed in order — are: Public Administration; Arts, Entertainment & Recreation; Retail Trade; Other Services; Wholesale Trade; Health Care & Social Assistance; Educational Services; Transportation & Warehousing; Finance & Insurance; Professional, Scientific & Technical Services; Utilities; and Information. The four industries reporting a decrease in new orders for the month of November are: Real Estate, Rental & Leasing; Management of Companies & Support Services; Construction; and Accommodation & Food Services.

    New Orders

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    23.7

    59.7

    16.6

    52.9

    Oct 2025

    27.8

    55.9

    16.3

    56.2

    Sep 2025

    20.6

    63.2

    16.2

    50.4

    Aug 2025

    27.2

    56.6

    16.2

    56.0

    Employment
    Employment activity in the services sector contracted in November for the sixth month in a row. The Employment Index registered 48.9 percent, up 0.7 percentage point from the October figure of 48.2 percent and its highest reading since May (50.7 percent). Comments from respondents include: “Filling vacancies” and “Still not getting a lot of applications for positions, as we require work from our offices now.”

    The six industries reporting an increase in employment in November, in order, are: Retail Trade; Accommodation & Food Services; Agriculture, Forestry, Fishing & Hunting; Wholesale Trade; Health Care & Social Assistance; and Utilities. The eight industries reporting a decrease in employment in November — listed in order — are: Mining; Transportation & Warehousing; Management of Companies & Support Services; Public Administration; Construction; Professional, Scientific & Technical Services; Finance & Insurance; and Information.

    Employment

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    15.6

    65.9

    18.5

    48.9

    Oct 2025

    14.3

    67.8

    17.9

    48.2

    Sep 2025

    12.1

    71.8

    16.1

    47.2

    Aug 2025

    10.3

    72.9

    16.8

    46.5

    Supplier Deliveries
    In November, the Supplier Deliveries Index indicated slower performance for the 12th month in a row. The index registered 54.1 percent, up 3.3 percentage points from the 50.8 percent recorded in October. This is its second highest reading since October 2022 (56.2 percent). A reading above 50 percent indicates slower deliveries, while a reading below 50 percent indicates faster deliveries. Comments from respondents include: “Tariffs — items being stopped at borders” and “We are being told that the government shutdown has led to slower customs processing at the borders.”

    The nine industries reporting slower deliveries in November — in the following order — are: Accommodation & Food Services; Management of Companies & Support Services; Information; Agriculture, Forestry, Fishing & Hunting; Real Estate, Rental & Leasing; Professional, Scientific & Technical Services; Finance & Insurance; Educational Services; and Utilities. The three industries reporting faster supplier deliveries for the month of November are: Construction; Retail Trade; and Health Care & Social Assistance. Six industries reported no change in Supplier Deliveries in the month of November.

    Supplier Deliveries

    %Slower

    %Same

    %Faster

    Index

    Nov 2025

    12.6

    82.9

    4.5

    54.1

    Oct 2025

    5.1

    91.4

    3.5

    50.8

    Sep 2025

    9.7

    85.7

    4.6

    52.6

    Aug 2025

    4.5

    91.5

    4.0

    50.3

    Inventories
    The Inventories Index returned to expansion territory, registering 53.4 percent, a 3.9-percentage point increase compared to the 49.5 percent reported in October. Of the total respondents in November, 28 percent indicated they do not have inventories or do not measure them. Comments from respondents include: “Coming off a quiet storm season for our service territory; the next step is to consume the materials over the next several months and begin ramping up again next spring” and “We have started reducing inventories to normal levels after some trade deals have been resolved.”

    The eight industries reporting an increase in inventories in November — in the following order — are: Arts, Entertainment & Recreation; Retail Trade; Real Estate, Rental & Leasing; Transportation & Warehousing; Utilities; Public Administration; Wholesale Trade; and Professional, Scientific & Technical Services. The six industries reporting a decrease in inventories in November — listed in order — are: Management of Companies & Support Services; Other Services; Educational Services; Construction; Information; and Health Care & Social Assistance.

    Inventories

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    19.0

    68.7

    12.3

    53.4

    Oct 2025

    13.8

    71.4

    14.8

    49.5

    Sep 2025

    12.5

    70.5

    17.0

    47.8

    Aug 2025

    19.3

    67.7

    13.0

    53.2

    Prices
    Prices paid by services organizations for materials and services increased in November for the 102nd consecutive month. The Prices Index registered 65.4 percent, 4.6 percentage points lower than the 70 percent recorded in October and 0.7 percentage point lower than its 12-month average of 66.1 percent.

    Fourteen industries reported an increase in prices paid during the month of November, in the following order: Accommodation & Food Services; Finance & Insurance; Information; Real Estate, Rental & Leasing; Management of Companies & Support Services; Professional, Scientific & Technical Services; Wholesale Trade; Agriculture, Forestry, Fishing & Hunting; Other Services; Educational Services; Health Care & Social Assistance; Utilities; Transportation & Warehousing; and Public Administration. Construction was the only industry reporting a decrease in prices paid in November.

    Prices

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    31.0

    64.6

    4.4

    65.4

    Oct 2025

    43.2

    51.4

    5.4

    70.0

    Sep 2025

    39.9

    56.9

    3.2

    69.4

    Aug 2025

    36.7

    60.7

    2.6

    69.2

    NOTE: Commodities reported as up in price and down in price are listed in the commodities section of this report.

    Backlog of Orders
    The ISM® Services Backlog of Orders Index was in contraction territory for the ninth consecutive month, and the reading of 49.1 percent was an 8.3-percentage point increase compared to the 40.8 percent reported in October, and its largest single-month increase since June 2022 (8.5 percent). Of the total respondents in November, 29 percent indicated they do not measure backlog of orders. Respondent comments include: “Our patient volume keeps increasing, and we are having difficulty hiring providers/staff for open positions” and “Additional orders/RFP for data center activity.”

    The six industries reporting an increase in order backlogs in November — in the following order — are: Educational Services; Utilities; Transportation & Warehousing; Management of Companies & Support Services; Public Administration; and Wholesale Trade. The five industries reporting a decrease in order backlogs in November are: Construction; Information; Professional, Scientific & Technical Services; Health Care & Social Assistance; and Real Estate, Rental & Leasing. Seven industries reported no change in order backlogs in the month of November.

    Backlog of Orders

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    15.9

    66.3

    17.8

    49.1

    Oct 2025

    13.8

    54.0

    32.2

    40.8

    Sep 2025

    15.0

    64.5

    20.5

    47.3

    Aug 2025

    6.9

    67.0

    26.1

    40.4

    New Export Orders
    Orders and requests for services and other non-manufacturing activities to be provided outside of the U.S. by domestically based companies contracted in November for the fifth straight month and eighth time in 2025. The New Export Orders Index registered 48.7 percent, up 0.9 percentage point compared to the October reading of 47.8 percent. Of the total respondents in November, 40 percent indicated they do not perform, or do not separately measure, orders for work outside of the U.S. Respondent comments include: “Europe is quite strong for the fourth quarter” and “Slower growth internationally due to tariffs.”

    The six industries reporting an increase in new export orders in November, in order, are: Educational Services; Transportation & Warehousing; Management of Companies & Support Services; Health Care & Social Assistance; Information; and Professional, Scientific & Technical Services. The five industries reporting a decrease in new export orders in November are: Real Estate, Rental & Leasing; Accommodation & Food Services; Wholesale Trade; Retail Trade; and Construction. Seven industries reported no change in exports in November.

    New Export
    Orders

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    11.2

    75.0

    13.8

    48.7

    Oct 2025

    14.1

    67.3

    18.6

    47.8

    Sep 2025

    11.4

    70.2

    18.4

    46.5

    Aug 2025

    11.5

    71.6

    16.9

    47.3

    Imports
    The Imports Index continued in into contraction territory in November, registering 48.9 percent, 5.2 percentage points higher than the 43.7 percent reported in October. Thirty-nine percent of respondents reported that they do not use, or do not track the use of, imported materials. Respondent comments include: “We are actively trying to source more products from U.S.-Mexico-Canada Agreement suppliers to mitigate the steep tariffs on food, apparel, and electronics from Asia” and “Imports remain at a lower level due to tariff uncertainty and resourcing strategy execution.”

    The six industries reporting an increase in imports for the month of November — listed in order — are: Arts, Entertainment & Recreation; Transportation & Warehousing; Management of Companies & Support Services; Utilities; Professional, Scientific & Technical Services; and Wholesale Trade. The five industries reporting a decrease in imports in November are: Real Estate, Rental & Leasing; Accommodation & Food Services; Other Services; Finance & Insurance; and Information. Seven industries reported no change in imports in November.

    Imports

    %Higher

    %Same

    %Lower

    Index

    Nov 2025

    12.3

    73.1

    14.6

    48.9

    Oct 2025

    6.9

    73.5

    19.6

    43.7

    Sep 2025

    11.7

    74.9

    13.4

    49.2

    Aug 2025

    18.9

    71.3

    9.8

    54.6

    Inventory Sentiment
    The ISM® Services Inventory Sentiment Index was in expansion (or “too high”) territory for the 31st consecutive month in November; the reading of 54.8 percent is a decrease of 0.7 percentage point from October’s figure of 55.5 percent. This reading indicates that respondents feel their companies’ inventory levels are too high when correlated to business requirements.

    The nine industries reporting sentiment that their inventories were too high in November — listed in order — are: Mining; Retail Trade; Wholesale Trade; Utilities; Agriculture, Forestry, Fishing & Hunting; Construction; Management of Companies & Support Services; Health Care & Social Assistance; and Transportation & Warehousing. The only industry reporting a decrease in inventory sentiment in November is Other Services. Eight industries reported no change in inventory sentiment in November.

    Inventory
    Sentiment

    %Too

    High

    %About
    Right

    %Too

    Low

    Index

    Nov 2025

    13.8

    81.9

    4.3

    54.8

    Oct 2025

    17.2

    76.6

    6.2

    55.5

    Sep 2025

    17.2

    76.9

    5.9

    55.7

    Aug 2025

    15.0

    80.9

    4.1

    55.5

    About This Report
    DO NOT CONFUSE THIS NATIONAL REPORT with the various regional purchasing reports released across the country. The national report’s information reflects the entire U.S., while the regional reports contain primarily regional data from their local vicinities. Also, the information in the regional reports is not used in calculating the results of the national report. The information compiled in this report is for the month of November 2025.

    The data presented herein is obtained from a survey of supply executives in the services sector based on information they have collected within their respective organizations. ISM® makes no representation, other than that stated within this release, regarding the individual company data collection procedures. The data should be compared to all other economic data sources when used in decision-making.

    Data and Method of Presentation
    The ISM® Services PMI® Report (formerly the Non-Manufacturing ISM® Report On Business®) is based on data compiled from purchasing and supply executives nationwide. Membership of the Services Business Survey Panel (formerly Non-Manufacturing Business Survey Committee) is diversified by the North American Industry Classification System (NAICS), based on each industry’s contribution to gross domestic product (GDP). The Services Business Survey Panel responses are divided into the following NAICS code categories: Agriculture, Forestry, Fishing & Hunting; Mining; Utilities; Construction; Wholesale Trade; Retail Trade; Transportation & Warehousing; Information; Finance & Insurance; Real Estate, Rental & Leasing; Professional, Scientific & Technical Services; Management of Companies & Support Services; Educational Services; Health Care & Social Assistance; Arts, Entertainment & Recreation; Accommodation & Food Services; Public Administration; and Other Services (services such as Equipment & Machinery Repairing; Promoting or Administering Religious Activities; Grantmaking; Advocacy; and Providing Dry-Cleaning & Laundry Services, Personal Care Services, Death Care Services, Pet Care Services, Photofinishing Services, Temporary Parking Services, and Dating Services). The data are weighted based on each industry’s contribution to GDP. According to U.S. Bureau of Economic Analysis (BEA) estimates (the average of the fourth quarter 2023 GDP estimate and the GDP estimates for first, second, and third quarter 2024, as released on December 19, 2024), the six largest services sectors are: Real Estate, Rental & Leasing; Public Administration; Professional, Scientific, & Technical Services; Health Care & Social Assistance; Information; and Finance & Insurance.

    Survey responses reflect the change, if any, in the current month compared to the previous month. For each of the indicators measured (Business Activity, New Orders, Backlog of Orders, New Export Orders, Inventory Change, Inventory Sentiment, Imports, Prices, Employment and Supplier Deliveries), this report shows the percentage reporting each response and the diffusion index. Responses represent raw data and are never changed. Data is seasonally adjusted for Business Activity, New Orders, Prices and Employment. All seasonal adjustment factors are subject annually to relatively minor changes when conditions warrant them. The remaining indexes have not indicated significant seasonality.

    The Services PMI® is a composite index based on the diffusion indexes for four of the indicators with equal weights: Business Activity (seasonally adjusted), New Orders (seasonally adjusted), Employment (seasonally adjusted) and Supplier Deliveries. Diffusion indexes have the properties of leading indicators and are convenient summary measures showing the prevailing direction of change and the scope of change. An index reading above 50 percent indicates that the services economy is generally expanding; below 50 percent indicates that it is generally declining. Supplier Deliveries is an exception. A Supplier Deliveries Index above 50 percent indicates slower deliveries and below 50 percent indicates faster deliveries.

    A Services PMI® above 48.6 percent, over time, indicates that the overall economy, or gross domestic product (GDP), is generally expanding; below 48.6 percent, it is generally declining. The distance from 50 percent or 48.6 percent is indicative of the strength of the expansion or decline.

    The ISM® Services PMI® Report survey is sent out to Services Business Survey Panel respondents in the first part of each month. Respondents are asked to ONLY report on U.S. operations for the current month. ISM® receives survey responses throughout most of any given month, with the majority of respondents generally waiting until late in the month to submit responses to give the most accurate picture of current business activity. ISM® then compiles the report for release on the third business day of the following month.

    The industries reporting growth, as indicated in the ISM® Services PMI® Report, are listed in the order of most growth to least growth. For the industries reporting contraction or decreases, those are listed in the order of the highest level of contraction/decrease to the least level of contraction/decrease.

    ISM PMI® Content
    The Institute for Supply Management® (“ISM®“) PMI® Reports, formerly Report On Business®, (Manufacturing and Services reports) (“ISM PMI®“) contain information, text, files, images, video, sounds, musical works, works of authorship, applications, and any other materials or content (collectively, “Content”) of ISM (“ISM PMI® Content”). ISM PMI® Content is protected by copyright, trademark, trade secret, and other laws, and as between you and ISM, ISM owns and retains all rights in the ISM PMI® Content. ISM hereby grants you a limited, revocable, nonsublicensable license to access and display on your individual device the ISM PMI® Content (excluding any software code) solely for your personal, non-commercial use. The ISM PMI® Content shall also contain Content of users and other ISM licensors. Except as provided herein or as explicitly allowed in writing by ISM, you shall not copy, download, stream, capture, reproduce, duplicate, archive, upload, modify, translate, publish, broadcast, transmit, retransmit, distribute, perform, display, sell, or otherwise use any ISM PMI® Content.

    Except as explicitly and expressly permitted by ISM, you are strictly prohibited from creating works or materials (including but not limited to tables, charts, data streams, time-series variables, fonts, icons, link buttons, wallpaper, desktop themes, online postcards, montages, mashups and similar videos, greeting cards, and unlicensed merchandise) that derive from or are based on the ISM PMI® Content. This prohibition applies regardless of whether the derivative works or materials are sold, bartered or given away. You shall not either directly or through the use of any device, software, internet site, web-based service, or other means remove, alter, bypass, avoid, interfere with or circumvent any copyright, trademark, or other proprietary notices marked on the Content or any digital rights management mechanism, device, or other content protection or access control measure associated with the Content including geo-filtering mechanisms. Without prior written authorization from ISM, you shall not build a business utilizing the Content, whether or not for profit.

    You shall not create, recreate, distribute, incorporate in other work or advertise an index of any portion of the Content unless you receive prior written authorization from ISM. Requests for permission to reproduce or distribute ISM PMI® Content can be made by contacting in writing at: ISM Research, Institute for Supply Management, 309 West Elliot Road, Suite 113, Tempe, Arizona 85284-1556, or by emailing [email protected]; Subject: Content Request.

    ISM shall not have any liability, duty or obligation for or relating to the ISM PMI® Content or other information contained herein, any errors, inaccuracies, omissions or delays in providing any ISM PMI® Content or for any actions taken in reliance thereon. In no event shall ISM be liable for any special, incidental, or consequential damages arising out of the use of the ISM PMI®. Report On Business®, PMI®, Manufacturing PMI®, Services PMI®, and Hospital PMI® are registered trademarks of Institute for Supply Management®. Institute for Supply Management® and ISM® are registered trademarks of Institute for Supply Management, Inc.

    About Institute for Supply Management®
    Institute for Supply Management® (ISM®) is the first and leading not-for-profit professional supply management organization worldwide. Its community of more than 50,000 in more than 100 countries around the world manage about US$1 trillion in corporate and government supply chain procurement annually. Founded in 1915 by practitioners, ISM is committed to advancing the strategy and practice of integrated, end-to-end supply chain management through leading edge data-driven resources, community, and education to empower individuals, create organizational value and to drive competitive advantage. ISM’s vision is to foster a prosperous, sustainable world. ISM empowers and leads the profession through the ISM® PMI® Reports (formerly Report On Business®), its highly regarded certification and training programs, corporate services, events and assessments. The ISM® PMI® Reports — Manufacturing and Services — are two of the most reliable economic indicators available, providing guidance to supply management professionals, economists, analysts, and government and business leaders. For more information, please visit: www.ismworld.org. 

    The full text version of the ISM® Services PMI® Report is posted on ISM®‘s website at www.ismrob.org on the third business day* of every month after 10:00 a.m. ET. The one exception is in January, the report is released on the fourth business day of the month.

    The next ISM® Services PMI® Report featuring December 2025 data will be released at 10:00 a.m. ET on Wednesday, January 7, 2026.

    *Unless the New York Stock Exchange is closed.

    Contact:

    Kristina Cahill


    PMI® Reports Analyst


    ISM®, PMI®/Research Manager


    Tempe, Arizona


    +1 480.455.5910


    Email: [email protected] 

    SOURCE Institute for Supply Management

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  • Bitcoin May Drop, But Crypto is Here to Say, Experts Say

    Bitcoin May Drop, But Crypto is Here to Say, Experts Say

    On Oct. 6, bitcoin hit an all-time high. 

    Things haven’t been going well since, with the cryptocurrency down 17% in November alone, and December starting out with a 7% drop, and then a 7% gain.

    What’s happening on the blockchain?

    Northeastern University cryptocurrency experts Ravi Sarathy and Alper Koparan said many macroeconomic factors — as well as the inherent volatility of bitcoin and other cryptocurrencies — are contributing to the recent wide swings in valuation.

    “I would say that, more than not, there is an overenthusiasm for all things crypto,” said Sarathy, professor of international business and strategy at Northeastern.

    But the experts also said bitcoin and cryptocurrencies in general are likely here to stay.

    “Cryptocurrency markets, I believe those markets will be there forever, regardless of the price of bitcoin,” said Koparan, an assistant teaching professor of finance. “It’s like a playground for individual investors. It’s something you can do over the internet without any limitations, restrictions. That activity will continue.”

    Bitcoin hit an all-time high of around $126,000 on Oct. 6, after rising 33% in 2025. But the world’s largest cryptocurrency by market value has since tanked — down roughly 14% by the end of October, down 17% in November,  and down another 7% on Dec. 1, although it erased that most recent loss the next day.

    Sarathy and Koparan both said that bitcoin — which arose from the 2008-2009 Great Recession as a decentralized, easy and fast, peer-to-peer trading network — is inherently volatile for several reasons. 

    First, its demand exceeds the total circulating supply, and its production is limited to 21 million coins, which the cryptocurrency is rapidly approaching. 

    Cryptocurrencies like bitcoin are also not tied to any country’s currency and are readily accessible to individual investors through the blockchain — a digital ledger where transactions are recorded. 

    Finally, cryptocurrencies have limited regulation. This can lead to frequent speculation — either buying bitcoin or a cryptocurrency and hoping to sell it for a quick profit or shorting it — or using bitcoin as leverage to buy more of a financial product. 

    “That’s really where I think the big, big volatility comes from,” Sarathy said.

    But it’s not just individual investors who are in on the game.

    While the Securities and Exchange Commission under President Joe Biden seemed “somewhat skeptical” of cryptocurrencies and blockchain-based ventures, the second Trump administration marked a “fairly dramatic shift” toward these ventures, Sarathy said.

    This encouraged institutional and corporate investors to enter the crypto market, particularly bitcoin, by investing in exchange-traded funds, or ETFs, related to crypto, Koparan said.

    But recently, institutional investors have reversed course, favoring safer assets such as gold and silver.

    “Within the last two years, we have seen significant inflow from funds or institutional investors on ETFs,” Koparan said. “But the end of October and November were months with negative flows.”

    Moreover, Koparan said global bond markets are in flux. 

    The Bank of Japan is expected to raise interest rates that have been around 0% for over a decade, while the Federal Reserve is expected to cut interest rates in the United States, Koparan explained. 

    This is prompting concerns of a reversal in the flow of “carry trades” that have fueled growth in the United States and other popular markets, Koparan said. 

    In a carry trade, an investor borrows in the currency of a country where interest rates are low, (for example, Japan) and uses it to invest in a currency where interest rates are higher, (for example, the United States) and then, upon the investments’ maturity, converts the net amount back to the original currency.

    “It may be certain investors read this as a warning signal,” Koparan said. “And what you would do in such a situation is you would simply exit high-risk investments, and bitcoin is one of them.”

    So, will the crypto market collapse as institutional investors flee bitcoin?

    Not necessarily. 

    “In the history of bitcoin, there are multiple time frames that we can relate to the events of today,” Koparan said. “The only difference today is that this price movement, price action is mostly due to institutional investors.”

    The market has weathered downturns before, most notably in the November 2022 FTX collapse, Sarathy added. 

    But he noted that the long-term trend for bitcoin should be considered. 

    In about 15 years, bitcoin has gone from zero to $120,000, and now it’s down to about $91,000, Sarathy said. “But it’s still pretty amazing.”

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  • SFO issues new guidance to end ‘box ticking’ corporate compliance

    SFO issues new guidance to end ‘box ticking’ corporate compliance

    Hinesh Shah and Melanie Ryan of Pinsent Masons were commenting after the SFO issued updated guidance clarifying its approach to evaluating businesses’ compliance programmes, particularly in light of the new failure to prevent fraud offence.

    The guidance outlines six scenarios in which the SFO may need to evaluate an organisation’s compliance programme, including: when considering prosecutions; deferred prosecution agreements (DPAs); compliance terms and monitorships; potential defences to corporate offences, and sentencing considerations.

    The biggest change follows the introduction of the new failure to prevent fraud offence, which was introduced by the Economic Crime and Corporate Transparency Act 2023 (ECCTA) and came into effect in September 2025.

    Under this new offence, a large organisation will be liable for economic crimes committed by an ‘associated person’, which includes directors, employees and agents of the organisation, who act for the benefit of the business or for the benefit of another associated person of the organisation. A ‘large organisation’ is one which meets two of three criteria: having a turnover of more than £36 million; a balance sheet total of more than £18m; and having more than 250 employees. Penalties include unlimited fines for businesses and separate criminal convictions for any individuals involved in committing the offence.

    The SFO says an organisation may have a defence “if, at the time of the offence, they had reasonable procedures in place to prevent fraud” or if the organisation can demonstrate that “it was not reasonable in the circumstance” to expect it to have any procedures in place. However, it reiterates that the burden of proof to prove this line of defence falls to the organisation itself.

    Shah, a forensic accountant at Pinsent Masons, said the updated guidance would send a strong signal to businesses to get their compliance procedures in order. “The refreshed SFO guidance reinforces the importance of practical compliance measures,” he said. “Organisations must go beyond having policies on paper and demonstrate real-world effectiveness, particularly in light of the new failure-to-prevent fraud offence under ECCTA. This means investing resources, embedding controls, ongoing monitoring, and effecting cultural change to mitigate risk and satisfy regulatory expectations.”

    Although the SFO acknowledges that many businesses already have “some level” of compliance in place, it says policies alone are insufficient and that compliance should entail developing and implementing anti-fraud and anti-bribery cultures, not tick-box exercises. It says that evaluation will be based on an organisation’s individual circumstances, not a one-size-fits-all model, and expects the revamped guidance to help determine how businesses’ “policies and procedures translate into conduct on the ground.”

    The updated guidance follows the publication of joint guidance on corporate prosecution issued by the SFO together with the Crown Prosecution Service in August 2025 and the SFO’s guidance on corporate cooperation and enforcement in relation to corporate criminal offending in April 2025. Separately, the Home Office also published its own statutory guidance in November 2024 that highlighted procedures that businesses can implement to prevent “associated persons from committing fraud” (PDF 46 pages / 516KB).

    Ryan, an investigations specialist at Pinsent Masons, said businesses should pay close attention to the new evaluation criteria to minimise the risk of failing to comply. “The updated guidance does not change the law – it clarifies how the SFO will evaluate compliance programmes and apply public interest factors,” she said. “Companies should focus on evidencing adequate or reasonable procedures, as these will be critical in defending enforcement actions and influencing decisions on deferred prosecution agreements.”

    The guidance applies to businesses operating across England, Northern Ireland and Wales. The SFO’s jurisdiction does not extend to Scotland, which operates its own self-reporting regime under the Crown Office and Procurator Fiscal Service (the COPFS).

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  • Focus: Hedge funds double down using near-record leverage in quest to boost returns – Reuters

    1. Focus: Hedge funds double down using near-record leverage in quest to boost returns  Reuters
    2. Bond termites, not vigilantes, are the big risk  Reuters
    3. Bank of England sounds alarm as foreign hedge funds snap up UK debt – latest updates  The Telegraph
    4. The Hedge-Fund ‘Basis Trade’ Is Booming in the U.K.—And the Bank of England Is Wary  The Wall Street Journal
    5. BOE Warns of Growing Gilt Risks From Hedge Funds’ Basis Trades  Bloomberg.com

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  • Developing Countries’ Debt Outflows Hit 50-Year High During 2022-2024

    World Bank Was Largest Provider of Net New Financing to 78 Most Vulnerable Countries

     

    WASHINGTON, December 3, 2025—Developing countries paid out $741 billion more in principal and interest on their external debt than they received in new financing between 2022 and 2024—the largest gap in at least 50 years, according to the World Bank’s latest International Debt Report released today.

    Still, most countries gained some breathing room on their debt last year as interest rates peaked and bond markets opened up again. That enabled many countries to stave off the risk of default by restructuring their debt. In all, developing countries restructured $90 billion in external debt in 2024, more than any time since 2010. Bond investors, meanwhile, pumped in $80 billion more in new financing than they received in principal repayments and interest. This helped several complete multi-billion-dollar bond issuances. However, the funds came at a high price—interest rates hovered around 10%, about double those before 2020.

    “Global financial conditions might be improving, but developing countries should not deceive themselves: they are not out of danger,” said Indermit Gill, the World Bank Group’s Chief Economist and Senior Vice President for Development Economics. “Their debt build-up is continuing, sometimes in new and pernicious ways. Policymakers everywhere should make the most of the breathing room that exists today to put their fiscal houses in order—instead of rushing back into external debt markets.”

    In 2024, the combined external debt of low- and middle-income countries hit an all-time high of $8.9 trillion—with a record $1.2 trillion owed by the 78 mainly low-income countries eligible to borrow from the World Bank’s International Development Association (IDA), the new report shows. The average interest rate that developing economies will pay to their official creditors on their newly contracted public debt in 2024 stood at a 24-year high. The average paid to private creditors was at a 17-year high. 

    In all, these nations paid a record $415 billion in interest alone—resources that could have gone to schooling, primary healthcare, and essential infrastructure. For instance, an average of one out of every two people in the most highly indebted countries was unable to afford the minimum daily diet necessary for long-term health.

    Low-cost financing became harder to obtain, except from multilateral development banks such as the World Bank, which was the single-largest provider of financing for IDA-eligible countries. In 2024, the World Bank provided a record $18.3 billion more in new financing to IDA-eligible countries than it received in principal and interest payments. It also provided a record $7.5 billion in grants to these countries. 

    Official bilateral creditors—mainly governments and government-related entities—retreated after participating in a wave of restructurings that cut the long-term external debt of some countries by as much as 70 percent. In 2024, bilateral creditors took in $8.8 billion more in principal and interest than they disbursed in new financing for developing countries. With options for low-cost financing dwindling, many developing countries turned to domestic creditors—local commercial banks and financial institutions. Of 86 countries for which domestic-debt data are available, more than half saw their domestic government debt grow faster than external government debt.

    “The rising tendency of many developing countries to tap domestic sources for their financing needs reflects an important policy accomplishment,” said Haishan Fu, the World Bank Group’s Chief Statistician and Director of its Development Data Group. “It shows their local capital markets are evolving. But heavy domestic borrowing can spur domestic banks to load up on government bonds when they should be lending to the local private sector. Domestic debt also comes with shorter maturities, which can raise the cost of refinancing. Governments should be careful not to overdo it.”

    The report also offers troubling new insights into how high debt levels have affected the daily lives of people in developing countries. It finds that among the 22 most highly indebted countries—those whose external debt stock exceeds 200% of export revenue—an average of 56% of the population is unable to afford the minimum daily diet necessary for long-term health. Eighteen of these countries are IDA-eligible countries, where nearly two-thirds of the population cannot afford the necessary diet. 

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  • EU unveils €3bn strategy to cut dependency on China for raw materials | Mining

    EU unveils €3bn strategy to cut dependency on China for raw materials | Mining

    The EU has unveiled a €3bn (£2.63bn) strategy to reduce its dependency on China for critical raw materials amid a global scramble triggered by Beijing’s “weaponisation” of supplies of everything from chips to rare earths.

    The ReSourceEU programme will seek to de-risk and diversify the bloc’s supply chains for key commodities with a funding initiative to support 25-30 strategic projects in the sector.

    The EU said the strategy was designed to reduce the impact of “market shocks” such as the recent disruption to the car industry caused by the recent, now lifted, ban on exports of chips by China in response to the Dutch government taking control of the Chinese-owned chip firm Nexperia.

    Senior EU officials said that “while the direction is clear” there was also a need to “accelerate the process” as China continued to “weaponise” its hold on raw materials for “geopolitical purposes”.

    These projects cover rare earths – a group of 17 heavy metals that are actually abundant but difficult and costly to extract – as well as the elements gallium, germanium, cobalt and lithium, used in batteries for electric vehicles.

    The plan centres on creating a European hub for critical materials that would pool company orders and build joint stockpiles for key projects including urgent defence programmes, an effort driven by the EU industry commissioner, Stéphane Séjourné

    The discussion comes as the French president, Emmanuel Macron, visits China, which has threatened to expand its controls on the exports of rare earths, including magnets used in everything from car and fridge doors to MRI scanners.

    As part of the new strategy, the EU will redouble efforts to recycle aluminium with fresh restrictions on scrap exports in 2026 of the metal and of scrap copper if necessary.

    It will also build a raw materials trading platform that can “aggregate demand” and procurement across the bloc and launch a stockpiling pilot in early 2026.

    Brussels has long complained that no matter how many defence measures it puts in place to protect against dependency on China, industry suppliers still buy from the country because it is cheaper than Chile, Brazil, Australia and Canada.

    The EU will also look at financial supports to bridge the cost of buying from pricier alternative locations.

    Demand for lithium is expected to increase nearly 60-fold by 2050. More than 78% of the EU’s lithium needs in 2020 came from Chile. Photograph: Luis Bustamante/The Guardian

    The strategy is designed to reboot the 2024 Critical Raw Materials Act that set targets for supplies for 2030 including capacity to extract 10% of the bloc’s needs locally, process 40%, and recycle 25%.

    Illustrating the scale of the reliance on Beijing, EU officials revealed that the bloc buys about 20,000 tonnes of permanent magnets a year, used in everything from car and fridge doors to MRI machines.

    Of that “17,000 to 18,000” tonnes come from China, 1,000 are produced in the EU with the remainder from other countries.

    Up to €3bn in funding will be mobilised within the next 12 months with €2bn a year made available by the European Investment Bank in the form of loans, venture debt and private debt plus financing such as loans already issued to a Finnish lithium mine project Keliber.

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    This dwarves the £50m announced last month by Keir Starmer for a similar initiative in the UK.

    Concerns that Europe could fall behind the US, Japan, Canada and Australia are widespread in industry, with large American car companies already working with mining conglomerates to reduce reliance on Beijing.

    Efforts by the US, the EU and the UK to reduce dependency on China for supplies took on a fresh urgency in October when China threatened to introduce sweeping controls on global exports of rare earths from December.

    That threat was lifted as part of the tariff deal struck between Xi Jinping and Donald Trump in South Korea six weeks ago, but the reprieve only holds for 12 months, preserving China’s future leverage on supply chains.

    The commission has previously estimated that the demand for rare earths and lithium alone is expected to increase five to 12 times and nearly 60 times, respectively, by 2050. In 2020, more than 98% of the EU’s rare earths imports came from China and 78% of its lithium needs were sourced from Chile.

    ReSourceEU is part of a wider package being unveiled on Wednesday that the commission calls its economic security doctrine, intended to make European firms more self-sufficient.

    Europe’s only lithium hydroxide factory, operated by AMG Lithium in Germany, cost £150m to build, and the company was already in the mining business.

    Earlier this year, its chief executive, Stefan Scherer, said that the EU might as well “apply to be a province of China” so little was being done in practice to cut reliance. “Europe has to become independent of China, otherwise it’s just blah blah blah,” he said.

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  • Today in Energy – U.S. Energy Information Administration (EIA)

    Today in Energy – U.S. Energy Information Administration (EIA)

    Filter by article type:







    In-brief analysis

    Dec 3, 2025






    Data source: Bloomberg L.P.
    Note: Data through November 26, 2025. All crack spreads are calculated against the Dated Brent crude oil spot price.


    Global refinery margins for diesel have widened since late October and increased to their highest level all year, following refinery outages in Russia and in the Middle East and new sanctions on Russia’s crude oil, leading to limited refinery production and a decreased global diesel supply. The impact was most pronounced in the Atlantic Basin, contributing to higher prices at the Amsterdam, Rotterdam, Antwerp (ARA) shipping hub, a key benchmark for European prices, as well as at New York Harbor and the U.S. Gulf Coast. The higher global prices also affected prices in the United States because U.S. refiners can sell into both domestic and international markets.

    Read More ›


    In-brief analysis

    Dec 1, 2025



    U.S. electric power interruptions


    U.S. electricity customers experienced an average of 11 hours of electricity interruptions in 2024, or nearly twice as many as the annual average experienced in the decade before, according to our Electric Power Annual 2024 report. Major events such as Hurricanes Beryl, Helene, and Milton accounted for 80% of the hours without electricity in 2024.

    Read More ›


    In-brief analysis

    Nov 26, 2025



    weekly U.S. average regular gasoline retail price


    Data source: U.S. Energy Information Administration, Gasoline and Diesel Fuel Update; U.S. Bureau of Labor Statistics (BLS)
    Note: Weekly data reflect U.S. average regular gasoline retail price for all formulations; real price is calculated using Consumer Price Index from BLS.



    On the Monday before Thanksgiving, the U.S. retail price for regular-grade gasoline averaged $3.06 per gallon (gal), just 2 cents/gal higher than the same time last year. After adjusting for inflation, however, this year marks the lowest average gasoline price for the Monday before the Thanksgiving holiday weekend since 2020, when the pandemic disrupted gasoline demand and travel plans.

    Read More ›


    In-brief analysis

    Nov 24, 2025



    California electricity generation by source


    Data source: U.S. Energy Information Administration, Electric Power Monthly
    Note: Coal represents less than 1% each year.



    Although natural gas generation still provides more electricity than any other source in California, electricity generation from natural gas has decreased over the past several years while generation from solar has increased.

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    In-brief analysis

    Nov 21, 2025



    annual natural gas production in major U.S. crude oil producing regions



    Data source: Enverus Drillinginfo
    Note: For consistency, the various state pressure bases used to measure natural gas volumes have been converted to the federal pressure base of 14.73 pounds per square inch absolute (psia) and 60°F.


    U.S. production of associated dissolved natural gas, also known as associated natural gas, increased by 6% last year, mirroring the growth in crude oil production from the Permian region. Associated natural gas production averaged 18.5 billion cubic feet per day (Bcf/d) in 2024, according to data from Enverus DrillingInfo.

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    In-brief analysis

    Nov 19, 2025



    Alaska average annual crude oil production


    • In our latest Short-Term Energy Outlook, we forecast crude oil produced from Alaska will reach 477,000 barrels per day (b/d) in 2026, the most since 2018.
    • After decades of decline, we expect a 13% (55,000 b/d) increase in Alaska oil production, the largest annual increase since the 1980s.
    • The recent growth is attributable to two projects on Alaska’s North Slope:
      • The Nuna project, owned by ConocoPhillips, started production in December 2024 and is expected to produce 20,000 b/d at its peak. In August 2025, the project produced 7,000 b/d, offsetting existing production declines.
      • The Pikka Phase 1 project, jointly owned by Santos and Repsol, is expected to start production during the first quarter of 2026 and reach peak production of 80,000 b/d by mid-2026, nearly 20% of total Alaska oil production in 2025.

    • The wells from these new projects outperform most Alaskan wells. Based on recent production records from the Alaska Oil and Gas Conservation Commission, these wells produce about 480 barrels of oil equivalent per day (BOE/d) on average, whereas 78% of Alaskan wells produced less than 400 BOE/d in 2023.
    • Our latest forecast for 2026 production—an increase from our initial forecast—reflects Santos’s expectations for an accelerated ramp-up to peak production for the Pikka Phase 1 project and recent well tests demonstrating high productivity.

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    In-brief analysis

    Nov 17, 2025



    U.S. lower 48 oil and gas rig count



    Data source: Baker Hughes Company
    Note: Excludes any miscellaneous rigs



    The average number of active rigs per month that are drilling for oil and natural gas in the U.S. Lower 48 states has declined steadily over the past few years from a recent peak of 750 rigs in December 2022 to 517 rigs this October. The declining rig count reflects operators’ responses to declining crude oil and natural gas prices and improvements in drilling efficiencies.

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    In-brief analysis

    Nov 14, 2025



    lower 48 states end-of-injection season natural gas inventories


    Working natural gas in storage in the Lower 48 states ended the natural gas refill season (April 1–October 31) with more than 3,900 billion cubic feet (Bcf), according to estimates based on data from our Weekly Natural Gas Storage Report released on November 6. U.S. inventories are starting winter 2025–26 at about the same level as last year, the most since 2016. As of October 31, inventories are 4% above the five-year (2020–24) average after above-average injections into storage throughout much of the injection season.

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    In-brief analysis

    Nov 13, 2025



    annual average retail and spot natural gas prices


    Driven by an increase in wholesale natural gas prices, retail U.S. natural gas prices for every sector have increased so far this year, although the increases are uneven across sectors. In our latest Short-Term Energy Outlook, we expect the 2025 annual average price of natural gas paid by electric power plants to increase by 37% and the price paid by industrial sector customers to increase by 21% compared with the 2024 averages. We forecast that natural gas prices for customers in the commercial and residential sectors will increase by less, at 4% each.

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    In-brief analysis

    Nov 10, 2025



    status of new U.S. solar photovoltaic generating capacity


    In the third quarter of 2025, solar projects representing about 20% of planned capacity reported a delay, a decrease from 25% in the same period in 2024, based on data compiled from multiple Preliminary Monthly Electric Generator Inventory reports.

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    In-brief analysis

    Nov 7, 2025



    top natural gas production countries and regions in 2023


    • The United States produced 104 billion cubic feet per day (Bcf/d) of natural gas, 75% more than the world’s second-largest natural gas producer, Russia, in 2023, the most recent year for which we have comprehensive worldwide data on natural gas production.
    • The United States has been the world’s largest producer of natural gas since 2009. More recently, U.S. natural gas production has increased further, averaging 106 Bcf/d for the first half of 2025 (1H2025).
    • Three regions in the United States are among the top 10 natural gas-producing areas in the world when ranked independently against other natural gas-producing countries:
      • The Appalachia region, in the northeastern United States, encompasses the Marcellus and Utica shale plays and ranked as the second-largest producer with 33 Bcf/d in 2023. More recently, production from the region has continued to average 33 Bcf/d in 1H2025.
      • The Permian region, in Texas and New Mexico, ranked fifth worldwide with 21 Bcf/d in 2023. Production from the Permian has since increased to average 25 Bcf/d in 1H2025.
      • The Haynesville region, in Texas, Louisiana, and Arkansas, ranked as the eighth-largest natural gas-producing area with 15 Bcf/d in 2023. Production from the Haynesville has declined slightly to average 14 Bcf/d in 1H2025.


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    In-brief analysis

    Nov 5, 2025



    lower 48 states crude oil and natural gas production by well vintage



    Data source: Enverus
    Note: Well vintage is the year a well first begins producing crude oil or natural gas



    As U.S. crude oil and natural gas production have increased, so has the volume of production declines from existing wells. To offset the increasing declines, operators today must bring on new wells to sustain or increase production levels.

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    In-brief analysis

    Nov 3, 2025



    port of Singapore bunker fuel sales by type


    Data source: U.S. Energy Information Administration, Maritime and Port Authority of Singapore (MPA), Bunker Sales
    Note: 2025 data are an estimate based on data through September. Distillate fuel oil includes marine gasoil (MGO), marine diesel (MDO), and low-sulfur marine gasoil (LSMGO). Heavy fuel oil includes marine fuel oil (MFO).


    When the International Maritime Organization’s lower marine sulfur limit known as IMO 2020 took effect in January 2020, commercial shippers pivoted sharply to fueling their vessels with low-sulfur fuel oil (LSFO). In the years since, high-sulfur fuel oil has reclaimed some market share, as a growing number of commercial vessels install sulfur scrubbers that allow operators to use the heavier, cheaper fuel oils while complying with the new sulfur emission limits.

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    In-brief analysis

    Oct 31, 2025



    quarterly U.S. coal exports


    • According to data released by the U.S. Census Bureau in September, the United States exported 46.8 million short tons (MMst) of coal in the first half of 2025 (1H25), an 11% decline from 1H24.
    • Steam coal exports totaled 22.5 MMst, a 10% decline from 1H24. Metallurgical coal exports totaled 24.2 MMst, a 13% decline from 1H24.
    • Reduced coal exports to China (4.4 MMst) accounted for 73% of the decline in total U.S. net coal exports. China accounted for 76% of the decline in metallurgical coal exports and 68% of the decline in steam coal exports.
    • U.S. exports to China decreased after China imposed a 15% additional tariff on imports of U.S. coal in February and a 34% reciprocal tariff on imports from the United States in April.
    • The reduction in total exports also reflects a global market characterized by declining coal prices caused by ample supply and soft demand. Meanwhile, coal consumption in the U.S. electric power sector has risen due to more demand and higher natural gas prices.

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    In-brief analysis

    Oct 29, 2025



    Brazil liquefied natural gas import capacity


    Companies operating in Brazil have expanded the country’s liquefied natural gas (LNG) regasification infrastructure since 2020, more than doubling its import capacity as the country seeks to diversify its energy supply and enhance energy security. Brazil’s regasification capacity grew from 2.5 billion cubic feet per day (Bcf/d) in 2020 to 5.1 Bcf/d in August 2025.

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  • Argentina’s Critical Minerals Sector: Opportunities and Challenges for Taiwanese Investment and Trade

    Argentina’s Critical Minerals Sector: Opportunities and Challenges for Taiwanese Investment and Trade

    Over the years, the Argentine government has taken significant steps to liberalize its mining sector. Under President Javier Milei (2023-present) and through the newly introduced Incentive Regime for Large Investments, Argentina is aiming to attract large-scale foreign direct investment (FDI) in mining, extraction, and processing of critical minerals such as lithium, gallium, germanium, and rare earths. [1] At the same time, there is a rising global demand for minerals in the technology, energy, and semiconductor industries. For Taiwan, which has an economy that is heavily reliant on advanced manufacturing, securing stable supplies for critical minerals is strategically relevant. In this context, Argentina presents an opportunity for Taiwanese investment and trade.

    Argentina: Mineral Resources, Policy, Trade & Investment Framework

    Argentina is endowed with a wide range of critical minerals. According to the Organization for Economic Cooperation and Development (OECD), beyond sizable lithium reserves, Argentina holds abundant copper, cobalt, chromium, rare earths, graphite, nickel, platinum-group elements, zinc, and other strategic minerals. In particular, Argentina is part of the “Lithium Triangle” (with Chile and Bolivia) and ranks among the world’s top lithium producers. Copper has also become a rapidly emerging focus, as numerous exploration projects are underway and the metal is considered essential for electrification and renewable energy infrastructure.

    Following the election of President Javier Milei in 2023, Argentina has advanced a legal and regulatory framework aimed at attracting large-scale mining investment. Key material factors include:

    • The Incentive Regime for Large Investments: Offers tax, customs, and foreign exchange benefits for projects exceeding USD 200 million, with 30 years of regulatory stability.
    • Export-Duty Reductions: In August 2025, Argentina eliminated export duties on 225 mining products through the Executive Decree No. 563/2025.
    • Transparency Commitments: Since joining the Extractive Industries Transparency Initiative in 2019, Argentina has maintained an online platform providing public access to mining, environmental, and cadastre data.
    • Institutional Framework: The Argentine Chamber of Mining Firms represents major companies and serves as a key industry interlocutor with the government.

    Together, these policies and institutions make Argentina a relatively favourable jurisdiction for mining investment—and one of the more open jurisdictions in the Lithium Triangle. In this regard, Argentina is the only country in the Lithium Triangle that allows private companies to own and commercialize lithium resources, while Chile and Bolivia maintain greater state control.

    Furthermore, following the results of Argentina’s October 2025 legislative elections, the current administration is expected to retain stronger control over Congress, reinforcing policy continuity and investor confidence. In this context, characterized by an openness to foreign capital, favorable investment conditions, and a liberalized mining regime, Argentina presents a unique opportunity for Taiwan to strengthen its non-official economic ties while ensuring greater resilience against potential disruptions from the People’s Republic of China (PRC) in its semiconductor supply chain. Additionally, President Milei’s alignment with the United States, the European Union, and other like-minded democracies further enhances the political feasibility of deeper Taiwan-Argentina cooperation.

    Taiwan: Dependence on Critical Minerals and Supply-chain Risks

    Taiwan’s advanced technology, semiconductor, and electronics industries rely heavily on a stable supply of critical minerals such as rare earth elements, lithium, copper, and germanium. However, due to its limited natural endowments and lack of domestic reserves, Taiwan’s supply chain remains highly dependent on external sources. 

    Critical minerals are fundamental to advanced technologies. Lithium, nickel, and cobalt underpin battery performance, while rare earth elements are indispensable for components in electric vehicle motors. However, Taiwan remains heavily dependent on external suppliers. In the first half of 2025, imports from the PRC and Hong Kong totaled USD 43.2 billion, with electronic components, information and communication products, and electrical machinery showing particularly strong growth. Taiwan also imported USD 58.1 million worth of mineral raw materials in 2024. Although its dependence on the PRC is significantly lower in the commodities category, accounting for only 1.6 percent of total mineral raw material imports, these figures still underscore Taiwan’s constrained access to the upstream raw materials needed to sustain its high-value manufacturing sectors.

    Source: External Trade Report in the First Half of 2025- Taiwanese Ministry of Finance

    It is worth noting that the critical minerals supply chain begins with upstream activities, which consist of exploration and extraction. Following extraction, the minerals enter the processing and refining stage, which serves as a bridge between raw mining output and industrial applications. Here, materials are transformed into usable forms. The downstream stages involve the industrialization of refined minerals as they move into manufacturing, where countries have greater opportunities to add value and diversify their production. The chain concludes with end-of-life management, which seeks to close the loop through recycling and reuse, ultimately reducing the demand for virgin materials.

    However, the distribution of capabilities across these stages is uneven, and this imbalance creates strategic vulnerabilities. In particular, mineral refining and processing capacity is highly concentrated in the PRC (accounting for almost 70 percent of the market share), posing significant geopolitical risks for Taiwan. Beijing’s imposition of export controls on critical minerals creates vulnerabilities for Taiwan. These factors could potentially lead to an economic blockade, disrupting the upstream of the mining industry and exacerbating supply chain bottlenecks. 

    A notable example is tungsten, a strategic metal essential to Taiwan’s industrial infrastructure. Taiwan does not produce its own raw tungsten and relies entirely on imports, with approximately 90 percent of its supply originating from China. In February 2025, China added tungsten to its export control list and eliminated value-added tax rebates for raw exports, effectively discouraging global supply and altering market dynamics. Industry managers have warned that a complete disruption in tungsten supply could force “half of Taiwan’s people” to take unpaid leave, highlighting the metal’s strategic importance.​ Additionally, in October 2025, Beijing introduced sweeping new export restrictions requiring companies worldwide to obtain licenses for any product containing more than 0.1 percent Chinese-origin rare earth elements by value. While Taiwan does not directly rely on China for rare earth elements used in its domestic chipmaking processes, it remains vulnerable through indirect channels—especially via its dependence on semi-finished products and components manufactured in Japan or Southeast Asia that use Chinese-refined rare earth elements.​

    Hence, diversification is essential for Taiwan to strengthen its industrial resilience and preserve its global competitiveness in high-tech sectors. Critical minerals are indispensable inputs for semiconductors, smart machines, electronics, battery systems, and green technologies. In particular, Taiwan’s semiconductor industry (anchored by firms such as Taiwan Semiconductor Manufacturing Company [TSMC, 台灣積體電路製造公司]), constitutes the foundation of its export economy and strategic position in the international system, given the large market share they hold. Any disruption in the supply of raw materials could pose systemic economic and security risks for not just Taiwan, but for the whole world.

    Although Taiwan and Argentina lack formal diplomatic relations, Taipei maintains commercial and cultural engagement through the Taipei Economic and Cultural Office in Argentina (駐阿根廷台北商務文化辦事處). Despite persistent pressure from the PRC, Taiwan has succeeded in promoting economic and institutional cooperation through Memoranda of Understandings (MOUs) between firms, chambers of commerce, and academic institutions. Building on these mechanisms, Taiwan can further advance bilateral ties with Argentina and other resource-rich partners to secure access to critical minerals and enhance the resilience of its industrial supply chains.

    Opportunities and Challenges for Taiwanese Investment and Trade

    For Taiwan, engaging with Argentina’s critical-minerals sector offers a route to diversify supply chains away from heavy reliance on the PRC and a narrow set of sources. By gaining access to minerals such as lithium, copper, rare earths and germanium from Argentina, Taiwanese firms can strengthen their upstream security of supply for semiconductors, electronics, magnets, battery technologies and smart machines. Given the geopolitical risks associated with China’s dominance in mineral processing and refining, diversification into Argentina is both economically prudent and strategically significant.

    Furthermore, instead of being purely downstream manufacturers, Taiwanese firms might explore upstream participation through joint ventures, equity shares, or trade partnerships in Argentina. Notable examples include the memorandum of understanding between the Chinese International Economic Cooperation Association (CIECA) and the Argentine Chamber of Commerce and Services (Cámara de Comercio y Servicios de la República Argentina), as well as the cooperation agreement between CIECA and the Chamber of Industry and Commerce of Mercosur and the Americas (Cámara de Industria y Comercio del Mercosur y de las Américas). This would allow Taiwan to evolve from a passive consumer of raw materials to an integrated actor within the Argentine emerging mining sector, improve value-chain capture, secure supply stability, and reinforce the competitiveness of its high-tech industries.

    In the absence of formal diplomatic relations between Taiwan and Argentina, cooperation can advance through provincial and regional levels, particularly in mining-rich provinces, such as Jujuy, Catamarca, and San Juan. Through chambers of commerce, investment promotion agencies, and sister-city agreements, access could be facilitated while circumventing federal-level diplomatic constraints. This decentralized approach would complement existing trade promotion mechanisms and foster ground-level partnerships.

    In addition, these engagements may also open doors in neighboring countries for Taiwan to build a regional critical minerals network, strengthen its political and economic position in Latin America’s Southern Cone -Brazil, Paraguay, Uruguay, and Chile-, reduce its diplomatic isolation, and increase its presence in a strategically significant region. Participation in the Argentine mining boom could also enhance Taiwan’s leverage in the global competition over supply chains, particularly vis-à-vis the PRC.

    However, the critical minerals sector in Argentina also presents notable challenges for Taiwanese businesses and investors. Geopolitically, the influence of the PRC remains substantial, reinforced by the Belt and Road Initiative (BRI, formerly known as “One Belt, One Road,” 一帶一路)  and extensive commercial presence in the country. As of September 2025, China had become Argentina’s second-largest trading partner, with the bilateral trade balance reflecting a USD 6.5 million deficit for Argentina. Moreover, the PRC maintains significant foreign direct investment in strategic sectors including energy, manufacturing, mining, real estate, ICT, infrastructure, agroindustry, and finance.

    At the same time, mining operations in Argentina face strict regulations and community opposition, with legislation that limits and restricts mining activity and investment. These issues are compounded by Argentina’s macroeconomic instability, including high inflation and uncertain investment and economic conditions, which may pose financial risks despite recent reforms. Altogether, these geopolitical, environmental, financial, and diplomatic constraints form a challenging landscape that Taiwan must carefully navigate to participate effectively in Argentina’s emerging critical minerals market.

    Recommendations

    In order to capitalize on the benefits of closer economic relations, Taiwan should:

    1. Sign an MOU between the Taipei Economic and Cultural Office in Argentina and the Argentine Chamber of Mining Firms [Cámara Argentina de Empresas Mineras]. The MOU should establish a framework for investment and dialogue, including information sharing, high-level reciprocal visits, and matchmaking between Argentine mining firms and Taiwanese investors.
    2. Direct the Taiwan External Trade Development Council (TAITRA, 中華民國對外貿易發展協會) to organize at least one annual trade mission to the Argentine provinces of Jujuy, Catamarca, and San Juan, focused on identifying trade and investment opportunities in critical mineral sectors. These missions should involve forming a working group among Taiwanese firms interested in diversifying raw material sourcing for semiconductors, as well as relevant Argentine stakeholders (federal, provincial, and regional governments, mining firms, and legislators). Through the Contact Taiwan platform, TAITRA should facilitate linkages between investors and recipients, and specify mining and processing projects suited for Taiwanese participation.
    3. Coordinate with like-minded partners, such as the United States, Canada, and the European Union (countries that already have significant investments in Argentina) to establish a multilateral forum on critical minerals. The forum would align investment cooperation frameworks and ensure Taiwan’s inclusion in broader supply chain initiatives.

    The main point: For Taiwan, the time is ripe to deepen its presence in Argentina’s mining sector; not merely as a buyer of raw materials, but also as a strategic partner in extraction, processing, and supply-chain integration. Doing so would strengthen Taiwan’s techno-industrial base and enhance its economic diplomacy in Latin America.


    [1] Critical minerals are defined as any mineral, element, substance, or material designated as critical by the Secretary of the Interior, acting through the director of the US Geological Survey. The Critical Materials List includes the following: Critical materials for energy: Aluminum, cobalt, copper, dysprosium, electrical steel, fluorine, gallium, iridium, lithium, magnesium, metallurgical coal for steelmaking (inclusive of anthracite), natural graphite, neodymium, nickel, platinum, praseodymium, silicon, silicon carbide and terbium. Critical minerals: Aluminum, antimony, arsenic, barite, beryllium, bismuth, cerium, cesium, chromium, cobalt, dysprosium, erbium, europium, fluorspar, gadolinium, gallium, germanium, graphite, hafnium, holmium, indium, iridium, lanthanum, lithium, lutetium, magnesium, manganese, neodymium, nickel, niobium, palladium, platinum, praseodymium, rhodium, rubidium, ruthenium, samarium, scandium, tantalum, tellurium, terbium, thulium, tin, titanium, tungsten, vanadium, ytterbium, yttrium, zinc, and zirconium.

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  • Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

    Mutations in the dynein cargo adaptor BICD2 have been linked to SMALED2 (Koboldt et al., 2020). Mutations in the heavy chain of the dynein motor have also been implicated in a version of this disorder (Chan et al., 2018; Das et al., 2018), suggesting that defects in dynein-mediated transport contribute to its etiology. However, the molecular and cellular mechanisms underlying SMALED2 pathogenesis remain poorly understood. Previous studies have characterized mutations within the first coiled-coil domain of BICD2, a region responsible for interactions with dynein and dynactin. These analyses elegantly demonstrated that mutants such as BICD2_N188T result in dynein hyperactivity (Huynh and Vale, 2017). In addition to these mutants, however, recent studies have identified several SMALED2-associated alleles within the C-terminal cargo-binding domain of BICD2 (Ravenscroft et al., 2016; Synofzik et al., 2014). Given BICD2’s role as a dynein cargo adaptor, these findings raise two important questions: (1) Is dynein hyperactivity a common feature of SMALED2-associated BICD2 mutations? and (2) Do these mutations alter the interactome of BICD2 relative to the wild-type protein? The goal of this study was to address these questions and elucidate potential molecular consequences of SMALED2-associated BICD2 mutations.

    BICD2 is one of the best characterized dynein cargo adaptors. However, most studies involving BICD2 have focused on the mechanism by which this adaptor activates dynein for processive motility. Relatively little is known regarding the cargo that is linked to dynein by BICD2. In Drosophila, BicD links the RNA-binding protein Egalitarian (Egl) with dynein for transport of specific mRNAs in the oocyte and embryo (Dienstbier et al., 2009; Goldman et al., 2021; Goldman et al., 2019; Mach and Lehmann, 1997; McClintock et al., 2018). Loss of either BicD or Egl compromises transport of these mRNAs and consequently results in defective oogenesis or embryogenesis. The first definitive cargo identified for mammalian BICD2 was the small GTP-binding protein, RAB6A (Matanis et al., 2002). Despite the ability of BICD2 to directly bind RAB6A, most vesicles containing RAB6A move towards the plus end of microtubules, suggesting that their transport is primarily driven by the Kinesin-1 motor, KIF5B (Grigoriev et al., 2007). Other cargos that have been shown to directly bind BICD2 are RANBP2, a nucleoporin, and Nesprin-2 (SYNE2), a LINC complex component involved in linking dynein and kinesin to the nuclear envelope (Gonçalves et al., 2020; Splinter et al., 2010).

    In order to determine whether SMALED2 alleles of BICD2 are associated with interactome changes, it was therefore critical for us to determine the interactome of wild-type BICD2. This was done using the promiscuous biotin ligase miniTurboID (mTrbo). In comparison to an RFP-mTrbo control, BICD2-mTrbo resulted in the biotinylation and purification of numerous known interacting partners including RANBP2, as well as several components of the dynein motor. One interesting group of potentially novel interacting proteins was components of the HOPS complex, a six-subunit complex of proteins involved in endocytic trafficking (Spang, 2016). Four of the six HOPS components were identified in the wild-type BICD2 interactome, with VPS41 being the fifth most enriched protein. However, unlike RANBP2, RAB6A, and NESPRIN-2, all of which are able to bind the isolated BICD2 cargo binding domain (Gonçalves et al., 2020; Matanis et al., 2002; Splinter et al., 2010), the HOPS complex components were only able to bind full-length BICD2. The BICD2 cargo binding domain was therefore necessary but not sufficient for interaction with HOPS components. In addition, contrary to our initial hypothesis that VPS41 was the direct binding partner between BICD2 and the HOPS complex, BICD2 retained its interaction with VPS16 and VPS18 in cells depleted of VPS41. This suggests that BICD2 likely recognizes a domain or motif present in several HOPS proteins. We attempted to use Alphafold2 multimer to predict the relevant domain within HOPS proteins that interact with BICD2. Although Alphafold2 was able to generate a high confidence prediction of the interaction site between BICD2 and RAB6A, consistent with published results (Zhao et al., 2024), it failed to produce a high confidence prediction for the BICD2-HOPS complex interaction (data not shown). Thus, although we were able to validate the in vivo association between BICD2 and VPS41, VPS16, and VPS18, we are not able to conclude whether BICD2 is capable of directly interacting with these proteins. To the best of our knowledge, this is the first example of BICD2 interacting proteins that display this binding characteristic. The ScaC protein from the intracellular pathogen Orientia tsutsugamushi was recently also shown to interact with BICD2, and although the binding site of ScaC was different from that used by RANBP2 or RAB6A, it was still able to interact with the isolated cargo binding domain of BICD2 (Manigrasso et al., 2025).

    Another unusual aspect of the BICD2-HOPS complex interaction is that it does not appear to be linked to dynein-mediated trafficking. Depletion of dynein heavy chain resulted in the peripheral distribution of GFP-VPS41 and LAMP1 vesicles, indicative of a reduction in minus end transport, and a net gain in plus end directed transport. By contrast, depletion of BICD2 resulted in the perinuclear accumulation of lysosomal vesicles that were mostly immotile. Interestingly, however, overexpression of BICD2 caused the outward spreading of LAMP1 vesicles, a process that depends on KIF5B (Guardia et al., 2016). Previous studies have shown that BICD2 is also able to interact with KIF5B via a central coiled coil domain (Grigoriev et al., 2007; Hoogenraad and Akhmanova, 2016). A recent report suggests that Drosophila BicD is capable of interacting with and activating the motility of Kinesin-1, the fly homolog of KIF5B (Ali et al., 2025). Consistent with the notion that BICD2 might link late endosomal vesicles with KIF5B, depletion of KIF5B in BICD2 overexpressing cells restored the normal localization of LAMP1 vesicles. Additional studies will be required to determine whether BICD2 is capable of directly interacting with these vesicles and whether these vesicles are directly linked to KIF5B by BICD2.

    The motility of LAMP1 vesicles has some similarity to the transport of RAB6A exocytic vesicles. RAB6A vesicles are transported from the area of the Golgi towards the cell periphery in a KIF5B-dependent manner, and loss of either kinesin-1 or dynein results in a sharp reduction in the number of motile particles (Grigoriev et al., 2007). In addition, mutations in BICD2 that compromise binding to RAB6A also result in vesicles that are largely immotile (Zhao et al., 2024). Thus, in the case of LAMP1 and RAB6A vesicles, instead of resulting in an increased rate of minus end transport, loss of BICD2 results in compromised vesicle motility, indicating that coordination between opposite polarity motors is critical for their motility.

    As noted earlier, mutations in the CC1 region of BICD2 hyperactivate dynein (Huynh and Vale, 2017). Our findings indicate that this property is also shared by BICD2_R694C and BICD2_R747C, mutations present within the C-terminal cargo binding domain. In the absence of cargo, BICD2 is thought to exist in an inhibited conformation due to intramolecular interactions between the N and C termini of the protein (Figure 1B; Liu et al., 2013; Terawaki et al., 2015; Wharton and Struhl, 1989). Cargo binding to the C-terminus of BICD2 counteracts the intramolecular interaction, enabling N-terminal residues within BICD2 to bind the dynein/dynactin complex (Goldman et al., 2019; Huynh and Vale, 2017; Liu et al., 2013; McClintock et al., 2018; Sladewski et al., 2018). How might mutations in BICD2 result in dynein hyperactivation? One possibility is that these mutations disrupt the autoinhibited state of BICD2, effectively causing BICD2 to be present in a more open and uninhibited conformation that promotes dynein/dynactin binding. Molecular dynamics simulations suggest that the R747C substitution causes a registry shift in the coiled coil, likely destabilizing this domain and thus disrupting the intramolecular interaction between the N and C termini of BICD2 (Cui et al., 2020). Another possibility is that the hyperactivation of dynein results in reduced binding between BICD2 and KIF5B. Our results are consistent with this scenario and suggest that the net effect of dynein hyperactivity results in three molecular changes; reduced intramolecular BICD2 interaction, increased interaction between BICD2 and dynein, and reduced interaction between BICD2 and KIF5B.

    In addition to hyperactivating dynein, all three mutations, including BICD2_N188T, alter the BICD2 interactome. This finding was unexpected for BICD2_N188T because this mutation is not within the cargo binding domain. One possible explanation for this phenotype is that BICD2_N188T is present in a more open conformation, and this change affects its binding properties. Another possibility that is not mutually exclusive is that the different binding profile results from the altered localization of BICD2_N188T within the cell. In comparison to wild-type BICD2, we generally observed greater centrosomal enrichment of BICD2_N188T. In comparing the three mutants, the general trend was that more proteins displayed a reduced interaction with the SMALED2 mutants in comparison to wild-type BICD2. Among the three mutants analyzed, BICD2_R747C displayed the most drastically altered interactome. This mutant displayed reduced association with RANBP2, importin beta, and HOPS complex components. Interestingly, this mutant also displayed numerous gain-of-function interactions. For instance, although minimal binding was observed between wild-type BICD2 and GRAMD1A, this protein abundantly interacted with BICD2_R747C. GRAMD1A is involved in non-vesicular transport of accessible cholesterol from the plasma membrane to the ER and is often concentrated at sites of plasma membrane-ER contact (Besprozvannaya et al., 2018; Sandhu et al., 2018). However, in cells expressing BICD2_R747C, this localization pattern was disrupted and GRAMD1A co-localized with BICD2_R747C adjacent to the centrosome.

    The GRAMD1 family consists of three isoforms: GRAMD1A, GRAMD1B, and GRAMD1C. Interestingly, our interactome analysis only identified GRAMD1A as a gain-of-function interaction partner with BICD2_R747C. It is unclear whether GRAMD1B and GRAMD1C also interact with BICD2_R747C. However, given that GRAMD1 proteins can form hetero oligomers (Naito et al., 2019), the BICD2_R747C-induced mislocalization of GRAMD1A could potentially affect the distribution of other GRAMD1 isoforms as well. The GRAMD1 proteins function to sense excess accessible cholesterol in the plasma membrane and to mediate the transport of this cholesterol to the ER. This reduces the rate of new cholesterol synthesis by the ER, enabling the cell to maintain cholesterol homeostasis (Sandhu et al., 2018). It will be interesting to determine whether endogenous GRAMD1A is mislocalized in motor neurons of SMALED2 patients with the BICD2_R747C mutation, and if this results in an expanded accessible pool of cholesterol at the plasma membrane.

    A recent study by Yi and colleagues examined the effect of the BICD2_R694C mutation on cargo binding (Yi et al., 2023). Using in vitro experiments, they found that this mutation enhanced RANBP2 binding while having no effect on NESPRIN-2 binding (Yi et al., 2023). Our results using full-length BICD2 are consistent with this finding. We also observed slightly higher binding of BICD2_R694C to RANBP2. However, due to experimental variability, the increase was not statistically significant. The authors also examined cargo binding using a BICD2 double mutant (F743I/R747C). Consistent with our results, this mutant displayed greatly reduced binding to RANBP2, but bound NESPRIN-2 at a much higher level than the wild-type protein (Yi et al., 2023). NESPRIN-2 was not identified as an interacting partner in our study for the wild-type protein or the BICD2_R747C mutant, possibly due to its low expression level in HEK293 cells. Nevertheless, these findings, along with our interactome analysis, indicate that mutations in the cargo binding domain of BICD2 can result in loss- and gain-of-function interactions.

    In conclusion, our study is the first to comprehensively examine the interactome of wild-type BICD2 and to identify changes that occur in SMALED2 linked mutant alleles of BICD2. We find that not only are mutations within the cargo binding domain associated with interactome changes, but these mutations are also capable of hyperactivating dynein. Some limitations of this study are worth noting. In the current study, we chose to determine the BICD2 interactome in HEK FLP-In cells (embryonic kidney cells). These cells were chosen because they enabled us to precisely integrate wild-type and mutant alleles of BICD2 at a specific locus. It also enabled us to expand cultures of these cells to levels that were sufficient for proteomic analysis. However, the main cell type affected in patients with SMALED2 is motor neurons. Primary motor neurons are harder to culture to scale and to genetically manipulate to express the desired wild-type or mutant BICD2 transgenes. Thus, although motor neurons were not used in our study, the next significant challenge will be to perform these types of experiments using motor neurons. In addition, although our study identified interactome changes between wild-type and mutant alleles of BICD2, we cannot conclude whether these changes are causative for the symptoms associated with SMALED2. Patients diagnosed with this disorder display a range of symptoms, from relatively mild to more severe (Frasquet et al., 2020; Koboldt et al., 2020). Even patients with the same genetic mutation can display a range of phenotypes (Storbeck et al., 2017). Furthermore, disease symptoms can result from one or two interactome changes that are critical for the health of motor neurons. Alternatively, symptoms might also be caused by many small changes in the interactome that cumulatively affect the health of motor neurons. Lastly, because SMALED2 is an autosomal dominant disorder, patients express wild-type and mutant versions of BICD2 in the same cell. Thus, to accurately model this disorder, studies will need to be conducted in motor neurons that are genetically edited to express disease-associated mutations in a heterozygous state.

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