Category: 3. Business

  • ‘It’s more critical than ever to address’

    ‘It’s more critical than ever to address’

    ChatGPT’s popularity exploded instantly upon its November 2022 debut — acquiring a staggering 100 million active users in two months — but concerns about the technology’s drain on resources have risen in tandem.

    Quantifying the environmental impact of generative artificial intelligence (AI) and large language models (LLMs) like ChatGPT has been an elusive endeavor, and as The Guardian observed, OpenAI and CEO Sam Altman have been frustratingly opaque about the energy demands of its newest offering, GPT-5.

    What’s happening?

    Per The Guardian, as of mid-2023, a simple query using ChatGPT used “about as much electricity as an incandescent bulb consumes in 2 minutes.”

    Research published as a preprint in March 2023 looked at ChatGPT’s water usage, asserting that training the GPT-3 model could “directly evaporate 700,000 liters of clean freshwater, but such information has been kept a secret.”

    On August 7, ChatGPT’s parent company OpenAI introduced GPT-5, its latest and most feature-heavy offering.

    GPT-5 represented “a significant leap in intelligence over all our previous models, featuring state-of-the-art performance across coding, math, writing, health, visual perception, and more,” OpenAI claimed as the model was unveiled.

    The Guardian’s coverage pointed out that ChatGPT’s usage of resources would likely increase in conjunction with its capabilities, adding that OpenAI had been markedly silent on the subject over the past five years.

    While OpenAI hasn’t been forthcoming, experts weighed in on what they suspect is necessarily a thirstier, energy-gobbling ChatGPT model.

    “A more complex model like GPT-5 consumes more power both during training and during inference … I can safely say that it’s going to consume a lot more power than GPT-4,” said University of Illinois professor Rakesh Kumar, who researches AI and energy usage.

    Why is GPT-5’s energy usage concerning?

    ChatGPT’s leap from a million to 100 million users wasn’t a blip — back in March, TechCrunch analyzed more recent usage trends following its introduction in November 2022.

    “By November 2023, ChatGPT had reached another milestone of 100 million weekly active users, which grew to 300 million by December 2024, then 400 million in February 2025,” the outlet explained.

    Citing initial calculations from the University of Rhode Island’s AI lab on Friday, August 8, The Guardian surmised that GPT-5’s capabilities could require an amount of energy that “would correspond to burning that incandescent bulb for 18 minutes.”

    Put another way, GPT-5 could use as much daily energy as 1.5 million households in the United States.

    University of California, Riverside, AI researcher Shaolei Ren said GPT-5’s energy requirements “should be orders of magnitude higher than that for GPT-3” based on its size alone.

    What can be done about AI’s environmental impact?

    Although AI researchers can make credible estimates, experts called for responsible corporate disclosures.

    “It’s more critical than ever to address AI’s true environmental cost. We call on OpenAI and other developers to use this moment to commit to full transparency by publicly disclosing GPT-5’s environmental impact,” said University of Rhode Island professor Marwan Abdelatti.

    Join our free newsletter for good news and useful tips, and don’t miss this cool list of easy ways to help yourself while helping the planet.

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  • S$0.002 (vs S$0.06 in 1H 2024)

    S$0.002 (vs S$0.06 in 1H 2024)

    SGX:KJ5 1 Year Share Price vs Fair Value

    Explore BBR Holdings (S)’s Fair Values from the Community and select yours

    BBR Holdings (S) (SGX:KJ5) First Half 2025 Results

    Key Financial Results

    • Revenue: S$114.4m (up 1.5% from 1H 2024).

    • Net income: S$510.0k (down 97% from 1H 2024).

    • Profit margin: 0.4% (down from 17% in 1H 2024).

    • EPS: S$0.002 (down from S$0.06 in 1H 2024).

    AI is about to change healthcare. These 20 stocks are working on everything from early diagnostics to drug discovery. The best part – they are all under $10bn in marketcap – there is still time to get in early.

    earnings-and-revenue-history
    SGX:KJ5 Earnings and Revenue History August 17th 2025

    All figures shown in the chart above are for the trailing 12 month (TTM) period

    BBR Holdings (S) shares are down 12% from a week ago.

    Risk Analysis

    Before we wrap up, we’ve discovered 4 warning signs for BBR Holdings (S) that you should be aware of.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team (at) simplywallst.com.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

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  • Qube Holdings Limited (ASX:QUB) Shares Could Be 43% Below Their Intrinsic Value Estimate

    Qube Holdings Limited (ASX:QUB) Shares Could Be 43% Below Their Intrinsic Value Estimate

    ASX:QUB 1 Year Share Price vs Fair Value

    Explore Qube Holdings’s Fair Values from the Community and select yours

    • The projected fair value for Qube Holdings is AU$7.82 based on 2 Stage Free Cash Flow to Equity

    • Qube Holdings’ AU$4.43 share price signals that it might be 43% undervalued

    • The AU$4.32 analyst price target for QUB is 45% less than our estimate of fair value

    How far off is Qube Holdings Limited (ASX:QUB) from its intrinsic value? Using the most recent financial data, we’ll take a look at whether the stock is fairly priced by taking the forecast future cash flows of the company and discounting them back to today’s value. We will use the Discounted Cash Flow (DCF) model on this occasion. It may sound complicated, but actually it is quite simple!

    We would caution that there are many ways of valuing a company and, like the DCF, each technique has advantages and disadvantages in certain scenarios. If you want to learn more about discounted cash flow, the rationale behind this calculation can be read in detail in the Simply Wall St analysis model.

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    We are going to use a two-stage DCF model, which, as the name states, takes into account two stages of growth. The first stage is generally a higher growth period which levels off heading towards the terminal value, captured in the second ‘steady growth’ period. To begin with, we have to get estimates of the next ten years of cash flows. Where possible we use analyst estimates, but when these aren’t available we extrapolate the previous free cash flow (FCF) from the last estimate or reported value. We assume companies with shrinking free cash flow will slow their rate of shrinkage, and that companies with growing free cash flow will see their growth rate slow, over this period. We do this to reflect that growth tends to slow more in the early years than it does in later years.

    Generally we assume that a dollar today is more valuable than a dollar in the future, and so the sum of these future cash flows is then discounted to today’s value:

    2026

    2027

    2028

    2029

    2030

    2031

    2032

    2033

    2034

    2035

    Levered FCF (A$, Millions)

    AU$229.5m

    AU$368.2m

    AU$481.6m

    AU$590.0m

    AU$688.5m

    AU$775.4m

    AU$851.1m

    AU$917.2m

    AU$975.6m

    AU$1.03b

    Growth Rate Estimate Source

    Analyst x3

    Analyst x2

    Est @ 30.82%

    Est @ 22.51%

    Est @ 16.69%

    Est @ 12.62%

    Est @ 9.76%

    Est @ 7.77%

    Est @ 6.37%

    Est @ 5.39%

    Present Value (A$, Millions) Discounted @ 8.2%

    AU$212

    AU$315

    AU$381

    AU$431

    AU$465

    AU$485

    AU$492

    AU$490

    AU$482

    AU$470

    (“Est” = FCF growth rate estimated by Simply Wall St)
    Present Value of 10-year Cash Flow (PVCF) = AU$4.2b

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  • AGL Energy Full Year 2025 Earnings: Revenues Beat Expectations, EPS Lags – uk.finance.yahoo.com

    AGL Energy Full Year 2025 Earnings: Revenues Beat Expectations, EPS Lags – uk.finance.yahoo.com

    1. AGL Energy Full Year 2025 Earnings: Revenues Beat Expectations, EPS Lags  uk.finance.yahoo.com
    2. Half the price, a lot more dense, but still very smart: Why baseload giant has doubled down on big batteries  RenewEconomy
    3. AGL grabs big share of EV home charging market as it plots future beyond coal  The Driven
    4. AGL’s looming capital crunch set to trigger asset sales  Capital Brief
    5. Australia’s top polluter bets on batteries as fossil fuel costs climb  The Sydney Morning Herald

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  • Companies Like Cordlife Group (SGX:P8A) Are In A Position To Invest In Growth

    Companies Like Cordlife Group (SGX:P8A) Are In A Position To Invest In Growth

    Even when a business is losing money, it’s possible for shareholders to make money if they buy a good business at the right price. For example, although software-as-a-service business Salesforce.com lost money for years while it grew recurring revenue, if you held shares since 2005, you’d have done very well indeed. Having said that, unprofitable companies are risky because they could potentially burn through all their cash and become distressed.

    So, the natural question for Cordlife Group (SGX:P8A) shareholders is whether they should be concerned by its rate of cash burn. In this article, we define cash burn as its annual (negative) free cash flow, which is the amount of money a company spends each year to fund its growth. First, we’ll determine its cash runway by comparing its cash burn with its cash reserves.

    This technology could replace computers: discover the 20 stocks are working to make quantum computing a reality.

    You can calculate a company’s cash runway by dividing the amount of cash it has by the rate at which it is spending that cash. When Cordlife Group last reported its June 2025 balance sheet in August 2025, it had zero debt and cash worth S$52m. In the last year, its cash burn was S$9.9m. Therefore, from June 2025 it had 5.3 years of cash runway. While this is only one measure of its cash burn situation, it certainly gives us the impression that holders have nothing to worry about. The image below shows how its cash balance has been changing over the last few years.

    SGX:P8A Debt to Equity History August 17th 2025

    View our latest analysis for Cordlife Group

    Cordlife Group actually ramped up its cash burn by a whopping 97% in the last year, which shows it is boosting investment in the business. That does give us pause, and we can’t take much solace in the operating revenue growth of 2.8% in the same time frame. Considering both these metrics, we’re a little concerned about how the company is developing. In reality, this article only makes a short study of the company’s growth data. You can take a look at how Cordlife Group has developed its business over time by checking this visualization of its revenue and earnings history.

    Cordlife Group seems to be in a fairly good position, in terms of cash burn, but we still think it’s worthwhile considering how easily it could raise more money if it wanted to. Generally speaking, a listed business can raise new cash through issuing shares or taking on debt. Many companies end up issuing new shares to fund future growth. By comparing a company’s annual cash burn to its total market capitalisation, we can estimate roughly how many shares it would have to issue in order to run the company for another year (at the same burn rate).

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  • Media Advisory for CUPE Air Canada Flight Attendants – Business Wire

    1. Media Advisory for CUPE Air Canada Flight Attendants  Business Wire
    2. Air Canada flight attendants in Winnipeg angry after feds order binding arbitration  CBC
    3. Air Canada and union ordered to bargaining table to end strike  BBC
    4. Canadian jobs minister intervenes in Air Canada strike, orders flight attendants back to work  CNN
    5. Canadian government moves to end Air Canada strike, seeks binding arbitration  Reuters

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  • Top Stocks, REITs, and Market Moves to Watch

    Top Stocks, REITs, and Market Moves to Watch

    The stock market continues to power ahead, with both Singapore and US equities presenting fresh opportunities. From top-performing stocks of the past decade to high-potential growth plays riding the AI and digitalisation wave, this week’s selection covers strategies for both capital gains and income investors. We also explore the winners and losers from Singapore’s telco shake-up, and highlight blue-chip and REIT ideas for long-term portfolios.

    Here are this week’s top articles:

    The Top 10 Singapore Stocks Over the Past Decade – And Which Ones Still Look Good Today
    A look back at the biggest winners over the last 10 years – and which ones could continue delivering strong returns in the years ahead.

    The Bull Market is Raging On: Should You Buy, Sell, or Hold Your Shares?
    With markets hitting new highs, we explore how to decide whether to lock in profits, stay invested, or add to your positions.

    4 Singapore REITs Unlocking Value to Boost Their DPU
    These REITs are enhancing their portfolios through acquisitions, asset enhancements, and strategic moves to grow unitholder returns.

    5 US Technology Growth Stocks to Ride the Digitalisation and AI Waves
    From cloud computing to AI, these US tech stocks are well-placed to benefit from powerful secular trends.

    Singapore’s Telco Consolidation: Who Are the Winners and Losers?
    The local telco landscape is evolving fast – here’s what it means for the major players and their investors.

    Earn While You Sleep: Build Passive Income with These 3 Singapore Dividend Stocks
    Looking for reliable dividend payers? These companies offer a steady stream of income alongside capital stability.

    4 Singapore Blue-Chip Stocks That You Can Own for Life
    Stalwarts with enduring business models that could anchor your portfolio for decades.

    SGX Added Two More Hong Kong Singapore Depository Receipts: Here’s What You Need to Know
    An update on SGX’s growing list of Hong Kong SDRs, offering investors a gateway to more cross-border opportunities.

    Here’s the best way to spend 5 minutes each week: Smart Reads. It gives you a fast, focused investing roundup so you don’t waste hours scrolling through the news.

    We handpick the best stories, ideas, and market updates that matter. Whether it’s dividend gems, capital growth plays, or key market shifts, you get them all in one email for free.

    Click here to join our community in Smart Reads, your smartest 15-minute read of the week.

    Follow us on Facebook, Instagram and Telegram for the latest investing news and analyses!

    The post Smart Reads of the Week: Top Stocks, REITs, and Market Moves to Watch appeared first on The Smart Investor.


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  • Claire’s was glitz ‘heaven’ for kids before Shein and TikTok came along

    Claire’s was glitz ‘heaven’ for kids before Shein and TikTok came along

    Matthew Chattle/Future Publishing via Getty Images Shoppers inside a Claire's store with rows of merchandiseMatthew Chattle/Future Publishing via Getty Images

    Claire’s has appointed administrators in the UK and Ireland

    For Beth Searby, a Saturday as a teenager wasn’t complete without going to Claire’s with her friend.

    But that tweenage rite of passage looks uncertain as the future of the chain hangs in the balance.

    Beth and her friends would use their pocket money in the late noughties to buy magnetic earrings, badges and toe rings from the accessories brand.

    “You never went home empty-handed,” says Beth, now 30.

    Shopping there was like an “analogue Temu,” she says.

    “You could go in with your bits of change that you had left from buying your McDonald’s or your Burger King and you could pick up a pair of earrings or a necklace or a badge to put on your school bag and you’d be spending 50p, £1, £2.”

    Beth Searby A teenager with curly shoulder-length brown hair smiles, in a brown cardigan and patterned shirt and blue necklace, with her elbow resting on a CybermanBeth Searby

    Beth’s teenage years included weekly trips to Lincoln, where she’d invariably end up in Claire’s

    Claire’s has appointed administrators in the UK and Ireland after battling with falling sales and high competition.

    It said its 278 shops in the UK and 28 in Ireland would continue trading while it considered “the best possible path forward”, but it’s stopped online sales.

    Originally a US brand, Claire’s opened its first UK store in the mid-90s and quickly became a mainstay among tweens who flocked there for affordable hair ties, glittery butterfly clips, matching friendship necklaces and lip gloss.

    “It was the ultimate shop for young people,” says Ella Clancy, 29.

    She remembers using her pocket money to buy earrings, scrunchies and Lip Smacker lip balms from Claire’s as a teenager.

    Particularly memorable are the so-called “nerd glasses” she and her friends got there – glasses with chunky, dark frames and no prescription.

    The shops were always “super pink and colourful and girly,” she says.

    “When you’re a little girl, it’s sort of like heaven,” says Vianne Tinsley-Gardener, 23.

    She would go to the Claire’s stores in Braintree, Essex, to buy keyrings, earrings and stationery.

    The shops were full of “unique little knick-knacks”, she says.

    Its lucky dips bags – where you didn’t know what you were getting – and multibuy offers like its five items for £10 deal turned shopping there into a treasure hunt and catered to tweens’ budgets.

    Claire’s was a staple for young people getting their ears pierced, too – and it often had special deals.

    Grace Dean/BBC Rows of matching "best friends" necklaces on rails at Claire's, including butterflies, hearts and other designsGrace Dean/BBC

    Claire’s sells matching friendship necklaces, for which the brand has become well known

    But many Claire’s shoppers found that some point during their time at secondary school, the brand just stopped being cool.

    They turned to places like Accessorize, Topshop and Primark instead.

    This was the case for Ceara Silvano, 23. She remembers it became too “kiddish” when she was about 13 and she started shopping at Primark instead.

    “You do just grow out of stuff like that,” Ceara says – though she still returned later to have her ears pierced at Claire’s.

    Grace Dean/BBC Items on sale at a Claire's store, next to a pink sign that says "Buy 3 get 3 free - absolutely everything"Grace Dean/BBC

    Claire’s still offers deals, like buying three items and getting another three for free

    Al Thomann loved Claire’s when they were younger because of its use of bright colours, glitter and floral designs.

    But as they grew up, they too started to see the brand as “childish” and stopped shopping there.

    “You start to feel like you’re a young adult, and all around me, most of the adults were not shopping at Claire’s,” Al, now 25, says.

    “Aspiring to be an adult meant rejecting that sort of childlike, colourful, rainbow, unicorn whimsy.”

    How young people shop is changing

    Back in the 2000s and 2010s, young people bought things because they liked them, rather than because they were trendy, says Constance Richardson, who owns the personal styling business By Constance Rose.

    But thanks to rising use of social media, young people are keeping up-to-date with what’s stylish online.

    “Shein can spot a trend on TikTok and have that live within days, often for much less money” than Claire’s, says Georgia Wright, a reporter at Retail Gazette.

    Shein, a Chinese online fast-fashion giant, sells a huge range of items including clothes, accessories and stationery for low prices.

    Claire’s, in comparison, doesn’t pounce on trends as quickly, Ms Wright says.

    And it can’t compete on price, Miss Richardson says. “They’re still selling novelty products at a non-novelty price.”

    Grace Dean/BBC Stickers, water bottles and tumblers on sale at Claire'sGrace Dean/BBC

    Claire’s has been trying to follow trends, but Georgia Wright says it can’t keep up with the likes of Shein

    Another factor is that young people are often influenced by creators on social media who are much older than them – and don’t shop at Claire’s.

    “Kids are growing up faster than ever,” says Ms Wright. “You’ve got 11 year olds with five-step skincare routines.”

    At the other end of the spectrum to Shein, they’re turning to more premium brands like Sephora, Space NK and Astrid and Miyu, she says.

    Claire’s “just doesn’t deliver the same excitement,” Ms Wright says.

    Al Thomann A person with shoulder-length wavy hair takes a selfie in a mirror, wearing a purple animal-shaped hat, a necklace and a black t-shirt. In the background is a computer and a fan with the Japanese flagAl Thomann

    Al says they use Claire’s products to display their identity

    But the brand still holds a special place in many people’s hearts.

    Ceara says she feels nostalgic about shopping at Claire’s and wishes she’d kept some items as mementoes.

    Whenever Ella walks past Claire’s stores, “it brings a little smile to my face”.

    And some people say they still enjoy shopping at the brand.

    “As I started university and started thinking about my own sexuality and gender identity and how I wanted to present myself, the sort of items that Claire’s sold once again came back into my field of knowledge,” Al says.

    “All of the really beautiful, very unique earrings and necklaces, bracelets, flower crowns, those kinds of things, were almost instruments to display my own identity in a way that was visible.”

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  • Trump tariffs target ‘Made in USA’ cowboy boots

    Trump tariffs target ‘Made in USA’ cowboy boots


    OUDTSHOORN:

    The manufacture of iconic “made in the USA” cowboy boots is set to suffer from President Donald Trump’s 30-percent tariffs on South African exports that came into force in August.

    Texas’s most renowned makers of the southern US fashion staple source the ostrich leather they require exclusively from the small South African town of Oudtshoorn, 400 kilometres (250 miles) east of Cape Town.

    Known as the world’s “ostrich capital”, Oudtshoorn is nestled in the semi-arid Little Karoo valley just inland from the southern coast and is home to a few hundred thousand people and about as many of the giant flightless birds.

    “We just don’t know how bad the impact will be, but positive it wouldn’t be,” said ostrich farmer Laubscher Coetzee of the tariffs that kicked in after South Africa appeared unable to negotiate a new trade deal with Trump.

    More than half of the global supply of ostrich-derived products — from feathers to leather and meat — comes from nearly 200 farmers around Oudtshoorn who are joined in the Cape Karoo International (CKI) group, said its managing director Francois de Wet.

    South Africa as a whole supplies about 70 percent of the world’s production, he said.

    Luxury handbag manufacturers in France and Italy are among the CKI’s main clients. It also ships 20 percent of its ostrich leather to top Texas bootmakers such as Lucchese, Justin and Rios of Mercedes, whose boots are sold at several hundreds of dollars a pair.

    Ostrich is “an extremely important leather in our industry”, Ryan Vaughan, CEO of the Rios of Mercedes manufacturer, told AFP.

    “It’s very resilient, it forms to the foot,” he said, wearing a typical cowboy hat. Coming from “a long line of cattle ranchers”, his family brand was born in Texas in 1853 and employs 250 people.

    The tariffs “would make a dramatic impact in our business and in the western industry,” he said, “because it’s not just us that build a lot of cowboy boots out of ostrich leather”.

    It is also the case of Tony Lama, an El Paso bootmaker supplied by CKI that has given a pair to every recent Republican president. Donald Trump received cowboy boots emblazoned with “MAGA” made out of “American alligator” skin, according to a press release.

    De Wet from the CKI said he believed the South African supply of ostrich leather to the US manufacturers did not run counter to a push by the Trump administration for production to be brought home.

    The United States did not have enough ostriches to provide the required leather, he said.

    “We export the raw material, the ostrich leather. They can’t produce it from local ostriches in the US. They don’t have them,” he told AFP.

    “They do all the value-adding in the United States,” he said. “So therefore, in terms of the pure definition of what the Trump administration would like to see, in this case, we do it already.”

    The soft skins, recognisable by spots left by the large ostrich feathers, are currently sold to American manufacturers for around $20 a square foot.

    “We exported more than the usual volume of ostrich leather to the US in the past two-three months, so we have a little bit of a buffer,” said de Wet.

    “For the moment we don’t expect any layoffs in the short term,” he said. But “in the long term, if we have to pick up the full tariff, it will definitely… cause a shrinkage of our business.”

    The consumer could also not be expected to pay an extra 30 percent for the already pricey boots, he said.

    “So the tariff will have to be split between the exporter… and the importer, and preferably also a part paid by the end consumer.”

    It is the unique climate of the Little Karoo, which gets less than 400 millimetres (nearly 16 inches) of rain a year, that makes it ideal for ostrich rearing, said Coetzee, a fourth-generation Oudtshoorn farmer.

    “That is the reason the ostrich industry is still here 200 years after (it started),” he said.

    His great-grandfather built the family home in 1896, when the price of ostrich feathers rivalled that of gold because of their value to the women’s fashion industry.

    The extravagant “ostrich palaces” of the time are a reminder of the industry’s previous major crisis, when the market collapsed in the early 1900s as the arrival of the low-roofed motor car ended the fashion for high-feathered hats.

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  • Guselkumab Improves Symptoms, Stigmatization with Long-Term Use for Psoriasis

    Guselkumab Improves Symptoms, Stigmatization with Long-Term Use for Psoriasis

    Long-term guselkumab use may improve skin symptoms, sexual impairment issues, and feelings of stigmatization in those with psoriasis, new data suggest.1

    These findings from the G-EPOSS study were recently published in the Journal of Dermatology and authored by such investigators as Sascha Gerdes, MD, of the Department of Dermatology at the University Medical Center Schleswig-Holstein, Campus Kiel in Germany. Gerdes and colleagues highlighted that issues related to sexual impairment can be experienced by more than half of all patients with psoriasis, especially those with anogenital psoriasis.2

    Additionally, the investigative team noted that perceived stigmatization is often experienced by an even greater number of patients, in turn exacerbating mental health issues and decreasing well-being.3

    “The G-EPOSS study aims to evaluate the long-term effectiveness of guselkumab for improving psoriasis, HRQoL, sexual impairment, and perceived stigmatization outcomes in patients with moderate-to-severe plaque psoriasis in routine clinical practice,” Gerdes and coauthors wrote.1,4 “Primary endpoint findings were previously published; here, we present key secondary endpoints from the final week (W)76 data cut, reporting outcomes across diverse patient subgroups.”

    G-EPOSS Trial Design

    The investigative team highlighted the design of G-EPOSS, noting that the study was an observational, prospective, multi-center investigation carried out in Germany. The team focused their attention on adult patients living with with moderate-to-severe plaque psoriasis. Those deemed eligible to participate in G-EPOSS had a confirmed diagnosis of moderate-to-severe plaque psoriasis with a baseline Psoriasis Area and Severity Index (PASI) score above 3, were at least 18 years of age, and were considered appropriate candidates for systemic medications.

    The implementation among these patients of non-biologic concomitant psoriasis drugs was permitted by Gerdes et al in accordance with routine clinical practice. The investigators’ patient recruitment period took place between October 2019 – August 2021 across 44 study sites. Those involved as participants were then treated with guselkumab 100 mg at the point of baseline, the 4-week mark, and subsequently every 8 weeks until the 76-week mark. This was noted as consistent with local clinical practice and guidelines for prescribing.

    Gerdes and coauthors’ primary endpoint was determined to be attainment of PASI ≤3 at Week 28, and such results were reported previously.4 Over the course of the full 76-week treatment period, the investigative team looked at such secondary endpoints as Dermatology Life Quality Index (DLQI), Nail Psoriasis Severity Index (NAPSI) scores, anogenital Physician’s Global Assessment (aPGA), Relationship and Sexuality Scale (RSS), Patient Benefit Index (PBI), the results of the Perceived Stigmatization Questionnaire (PSQ), and rates of drug survival.

    The team conducted their analyses among those in the overall cohort and in subgroups. These subgroups were defined by patients’ ages, body mass index (BMI), duration of disease, presence of anogenital psoriasis, sex, depression, and attainment of “super-responder” status. The latter group’s status was defined as PASI = 0 at both the 20 and 28-week marks.

    Guselkumab Effects on Psoriasis

    There were 295 patients included in the final analysis. Gerges and colleagues highlighted that at baseline, trial subjects’ mean disease duration had been 17.4 years and their mean PASI and aPGA scores were 15.3 and 2.7, respectively. In terms of prior biologic exposure, it had been observed among 26.4% of the G-EPOSS participants. At the 76-week mark, the team found that 87.5% of subjects reported PASI ≤3, and 47.3% achieved complete clearance (PASI = 0).1

    The investigators noted a substantial increase in response rates among trial participants showing a shorter duration of their disease. Overall, Gerdes et al found that 18.3% of the subjects met the aforementioned criteria for super-response. In those who entered the analysis with nail involvement (NAPSI ≥1) or anogenital disease (aPGA ≥1), complete clearance was seen in 52.2% (NAPSI = 0) and 75.8% (aPGA = 0) by the 76-week mark, respectively.

    Complete clearance of psoriasis in the anogenital region (aPGA = 0) was found by the investigators to be consistently high across all of the BMI categories. The team also noted significant improvements across all of the patient-reported outcomes they had assessed (DLQI, RSS, PSQ), and these benefits extended across each of the subgroups. Those with shorter psoriasis duration tended to report having greater improvement in some measures. 88.1% of subjects at Week 76 showed a PBI of >3, and treatment persistence was estimated at 88.7%. Notably, Gerdes and coauthors found no new safety concerns were during G-EPOSS.

    “The findings emphasize the importance of involving the patient’s view and considering sensitive topics not always openly communicated by patients,” the investigators concluded.1 “In summary, a holistic view of patients and their treatments is important for optimal care; G-EPOSS supports findings that guselkumab not only addresses physical symptoms but also improves overall patient wellbeing.”

    References

    1. S Gerdes, P Weisenseel, D Groß, et al. “Long-Term Impact of Guselkumab on Skin, Sexuality, and Perceived Stigmatization in Patients With Psoriasis in Routine Clinical Practice: Week 76 Effectiveness and Safety Results From the Prospective German Multicenter G-EPOSS Study,” The Journal of Dermatology (2025): 1–14, https://doi.org/10.1111/1346-8138.17866.
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