Category: 3. Business

  • Comparing Artificial Intelligence Large Language Models in Medical Training: A Performance Analysis of ChatGPT and DeepSeek on United States Medical Licensing Examination (USMLE) Style Questions

    Comparing Artificial Intelligence Large Language Models in Medical Training: A Performance Analysis of ChatGPT and DeepSeek on United States Medical Licensing Examination (USMLE) Style Questions


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  • Pakistan’s Oil and Gas Production Drops to Lowest in 20 Years

    Pakistan’s Oil and Gas Production Drops to Lowest in 20 Years

    Pakistan has reported its lowest oil and gas output in over two decades. Data from fiscal year 2025 (FY25) reveals a significant double-digit decline in both crude oil and natural gas production.

    Industry experts attribute the downturn to structural inefficiencies, regulatory challenges, and an oversupply of imported regasified liquefied natural gas (RLNG), which has displaced local production.

    According to a report by Topline Securities, Pakistan’s hydrocarbon production saw a sharp decline in FY25. Crude oil output dropped by 12% year-on-year (YoY), while natural gas production fell by 8% YoY. The decline was even more pronounced in the final quarter, with oil production decreasing by 8% quarter-on-quarter (QoQ) and 15% YoY, and gas production contracting by 7% QoQ and 10% YoY.

    The oversupply of RLNG played a significant role in this decline. A policy shift redirected industrial users from natural gas to the national power grid, while the government imposed an “off-grid levy” of Rs791 per million British thermal units (mmbtu) on captive gas consumption, raising the total cost to Rs4,291/mmbtu.

    This made gas-based electricity generation more expensive than grid power, discouraging industrial gas use and reducing demand for domestic production.

    Oil production averaged 62,400 barrels per day (bpd) in FY25, with major fields experiencing declines ranging from 3% to 46%. The Tal Block, which contributes around 17% of Pakistan’s total oil output, recorded a steep 22% YoY decline in the fourth quarter. Within the block, production from the Maramzai and Mardankhel fields plummeted by 54% and 52% YoY, respectively.

    Natural gas production also faced significant challenges, averaging 2,886 million cubic feet per day (mmcfd) in FY25. Major fields like Qadirpur and Nashpa saw sharp contractions in the fourth quarter, with output falling by 36% and 34% YoY, respectively. Even the Sui field, Pakistan’s largest gas producer, reported consistent declines.

    Topline Securities estimates that the increased reliance on imported fuels added over $1.2 billion to Pakistan’s foreign exchange burden in FY25. This reliance not only inflates the import bill but also leaves the country vulnerable to global fuel price volatility and potential supply disruptions.

    The outlook for FY26 remains bleak, with oil production projected to hover between 58,000-60,000 bpd and gas output expected to range from 2,750-2,850 mmcfd. Without significant policy changes or new investments in exploration and production (E&P), FY26 could mark the third consecutive year of declining hydrocarbon output.

    However, there is a glimmer of hope. The government is set to renegotiate its long-term RLNG supply agreement with Qatar in March 2026. Industry experts believe that more flexible contract terms could create room for domestic E&P companies to increase production, provided they prioritize field maintenance and capital investment. Balancing imported LNG with sustainable local production will be crucial for safeguarding Pakistan’s energy security and stabilizing its foreign exchange reserves.


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  • Dubai chocolate desserts hit state fairs as a hot-ticket item

    Dubai chocolate desserts hit state fairs as a hot-ticket item

    At the upcoming State Fair of Texas, confectioner Stephen El Gidi will offer up his own Dubai chocolate-inspired dessert — a base of rich Belgian chocolate and a pistachio spread layered like a sweet lasagna over cheesecake in a cup.

    It’s definitely a departure from the typical corn dogs and cotton candy.

    From the West Coast to Middle America, dessert creators at state fairs are hawking their own confections based on Dubai chocolate, a milk chocolate shell filled with creamy pistachio, tahini and crispy kataifi, a Middle Eastern pastry.

    The offerings derive inspiration from the original Dubai Chocolate, a bar created in 2021 by Sarah Hamouda, the founder of Fix Dessert Chocolatier, an online confectionary shop in Dubai.

    The bar quickly went viral, with influencers touting its gooey, crunchy goodness and Hamouda saying she was selling 100 bars per minute. Now, Dubai chocolate-inspired desserts have hit the masses and are popping up at a handful of state fairs for the first time this year.

    The Minnesota State Fair will offer a Dubai chocolate strawberry cup in late August. Wisconsin just featured its version of the Dubai chocolate bar. And the Orange County Fair in Southern California debuted a Dubai chocolate brownie last month. In May, the L.A. County Fair also sold a Dubai chocolate strawberry cup.

    Stephen El Gidi with his creation, Dubai Chocolate Cheesecake. State Fair of Texas

    El Gidi, who owns Drizzle Cheesecakes based in a Dallas suburb, is originally from Libya and moved to the U.S. in 2021 in hopes of becoming a business owner. He said he aims to sell between 15,000 and 20,000 cups this year at the state fair.

    “I became an entrepreneur because of my father, who is also a business owner. He inspired me to be my own boss,” El Gidi told NBC News.

    Stores like Trader Joe’s, Costco and even mall kiosks have featured their own versions of the chocolate bars for prices of around $3.99 and up. There’s even a Dubai chocolate pistachio shake at some Shake Shack locations featuring pistachio frozen custard with kataifi and a dark chocolate shell for $11.04.

    Currently, people in Dubai can order Hamouda’s bar, which she calls “Can’t get knafeh of it,” from her online shop or through a delivery service. It costs a little over $18 per bar. Additionally, chocolate aficionados can find the bar at Dubai International Airport’s duty-free store in Terminal 3.

    In May, product sales in the Confectionary category of Dubai Duty Free reached $20.2 million, up 81% thanks in part to Dubai chocolate, according to a press release from the company.

    The versions of Dubai chocolate people are buying in the U.S. are more a replication of the flavor profile than the real thing, says Kristie Hang, a food journalist based in Southern California’s San Gabriel Valley.

    These products are more wallet-friendly, selling for around $15 at grocery stores, and they’re made using standard ingredients like milk chocolate, strawberries and nut butters.

    Kristie Hang, food and culture expert, tries a viral Dubai chocolate cup.
    Kristie Hang, food and culture expert, tries a viral Dubai chocolate cup.Kristie Hang / via Instagram

    True Dubai chocolate, Hang says, is an artisanal dessert that’s made in small batches.

    “The pistachios are imported from Turkey and the chocolate is special chocolate with edible gold,” she said.

    There’s an element of luxury and craftsmanship to authentic Dubai chocolate, Hang added, noting a Dubai chocolate-covered strawberry confection would have only the finest, perfectly shaped strawberries dipped in high-quality Belgian or dark chocolate, paired with kataifi bits and pistachio cream from finely ground pistachios.

    “It’s definitely a mass fad at this point, but it’s far removed from what the original Dubai chocolate was intended for, which was an exclusive luxury item. Now, it’s being marketed as a very generic thing that anyone can get,” said Hang.

    From left, Arielle Federico Chellsie Duarte, Billy Duarte and Bianca Tamondong said they love trying food trends and posting about them.
    From left, Arielle Federico Chellsie Duarte, Billy Duarte and Bianca Tamondong said they love trying food trends and posting about them.Liz Rojas

    Texas-based food reviewer Zain Mohammed said he’s not a fan of the Dubai chocolate trend. Mohammed, who was born in Chicago, raised in Saudi Arabia and now reviews restaurants in Houston, said he thinks the proliferation of the dessert is glossing over the culture and the important role food plays in family.

    “There’s more to Dubai than just Dubai chocolate. I grew up in Saudi Arabia, and the Arab culture is very family-oriented and Arab hospitality is very unmatched.”

    He said he’s also worried about people benefiting from the trend without appreciating the culture. “I believe that there is cultural appropriation because of the fact that so many people are doing it — they are latching onto the trend and then advertising it as their own.”

    Bianca Tamondong, a college student who tried the Dubai brownie dessert from the Mom’s Bakeshoppe stand at the OC Fair, said she thought it was a winning combo. “I’ve tried so many other Dubai chocolate desserts before, such as the actual chocolate bar, ice cream variations and Dubai chocolate-covered strawberries. Ten dollars honestly seemed like such a steal since many other Dubai chocolate desserts cost $15.”

    “The pistachios balanced out the sweetness of the brownie perfectly,” she said.

    Confection connoisseur Dominic Palmieri sells a Dubai chocolate strawberry cup at the OC Fair.

    Dominic Palmieri points to a Dubai Chocolate Strawberry cup.
    Confection connoisseur Dominic Palmieri with a Dubai chocolate strawberry cup. OC Fair

    “It has all the components of the Dubai chocolate. However, we’re putting chocolate on top of the strawberries, and it’s got silky cream chocolate that doesn’t harden,” said Palmieri.

    It took more than three months to get enough pistachio cream for the fairs he’s participating in due to a pistachio shortage and high demand for pistachio cream. He projects securing around 2,000 gallons of pistachio cream and over 10,000 pounds of raw chocolate this year.

    It was rare for anyone to find Dubai chocolate in 2024. “You had to find it in specialty chocolate shops, sweet shops or different places that were doing dessert,” says Palmieri.

    Now, it’s everywhere, he says.

    “When you go to the fair, you’ll go get your corn dog, turkey leg, funnel cake, and you’ll get your Dubai chocolate strawberry cup. This one is quickly becoming a fan favorite,” Palmieri said.

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  • Gold price in Pakistan continues downward trend 

    Gold price in Pakistan continues downward trend 

    The price of gold in Pakistan as well as global market dropped for the sixth consecutive day on Saturday, reported 24NewsHDTV Channel. 

    According to the All Pakistan Sarafa Gems and Jewellers Association, the price of 24-karat gold per tola saw a drop of Rs900 on Saturday to reach Rs356,200. Similarly, the price of 10 grams of gold dropped by Rs771, taking it to Rs305,384. 

    The global market also witnessed a minor change, with the price of gold per ounce declining by just $9 to reach $3,335. The silver prices in Pakistan also witnessed a decline, with the price of a tola of 24-karat silver dropping to Rs4,031, and the price for 10 grams of silver to Rs3,455. 


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  • Exploring the role of lipid metabolism related genes and immune microenvironment in periodontitis by integrating machine learning and bioinformatics analysis

    Exploring the role of lipid metabolism related genes and immune microenvironment in periodontitis by integrating machine learning and bioinformatics analysis

    Identification of differentially expressed lipid metabolism related genes between periodontitis and healthy individuals

    The workflow of this study is display in Fig. 1A. A total of 74 differentially expressed lipid metabolism-related genes (DELMRGs) were identified through differential expression analysis. Among these, 44 genes were upregulated, while 30 genes were downregulated (Fig. 1B). The hierarchical clustering heatmap shows the detailed expression patterns of these DELMRGs (Fig. 1C). We then investigated the biological functions of the upregulated and downregulated LMRGs using GO and KEGG enrichment analyses. GO enrichment analysis revealed that the upregulated LMRGs were primarily involved in the phospholipid metabolic process, lipid catabolic process, regulation of phosphatidylinositol 3-kinase activity, regulation of inflammatory response, and regulation of lipid kinase activity (Fig. 1D). In contrast, the downregulated LMRGs were mainly associated with membrane lipid metabolism, membrane lipid biosynthesis, sphingolipid metabolism and biosynthesis, and fatty acid metabolism (Fig. 1F). KEGG enrichment analysis indicated that the upregulated LMRGs were significantly involved in the chemokine signaling pathway, phospholipase D signaling pathway, cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, and ether lipid metabolism (Fig. 1E). Meanwhile, the downregulated genes were primarily associated with arachidonic acid metabolism, fatty acid metabolism, and the biosynthesis of unsaturated fatty acids (Fig. 1G).

    Fig. 1

    Identification of differentially expressed lipid metabolism-related genes (LMRGs) in periodontitis and healthy individuals. (A) The workflow of this study. (B–C) Volcano plot (B) and hierarchical clustering heatmap (C) illustrating the 74 differentially expressed LMRGs in periodontitis and healthy individuals. (D–E) Significant terms of GO (Gene Ontology) enrichment analysis (D) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis (E) of the 44 upregulated LMRGs. (F–G) Significant terms of GO enrichment analysis (F) and KEGG enrichment analysis (G) of the 30 downregulated LMRGs.

    Hub lipid metabolism related genes identification by multiple machine learning approaches

    Next, three machine learning algorithms were employed to identify the most relevant diagnostic LMRGs for periodontitis. Random Forest (RF) identified 10 LMRGs based on importance scores, including FABP4, PLEKHA1, CWH43, CLN8, PDGFD, NEU1, HMGCR, CYP24A1, and OSBPL6 (Fig. 2A, B). Using LASSO regression, 16 LMRGs were identified after selecting the appropriate penalty parameter (Fig. 2C, D), with the coefficients of these genes shown in Fig. 2E. In the XGBoost model, the top 10 important LMRGs were CWH43, RORA, HSD11B1, PLEKHA1, ADGRF5, CLN8, FABP4, LYN, ENPP2, and OSBPL6 (Fig. 2F). Ultimately, five hub LMRGs were identified across these three algorithms: FABP4, CWH43, CLN8, ADGRF5, and OSBPL6 (Fig. 2G). We then explored the expression levels of these genes between periodontitis and healthy samples in the GSE16134 dataset. ADGRF5 and FABP4 were significantly upregulated in periodontitis samples compared to healthy tissues (Fig. 2H). Conversely, the expression levels of CWH43, CLN8, and OSBPL6 were significantly higher in healthy tissues than in periodontitis samples (Fig. 2H).

    Fig. 2
    figure 2

    Identification of hub lipid metabolism-related genes (LMRGs) as promising diagnostic biomarkers for periodontitis through machine learning framework. (A–B) Variable selection in the Random Forest algorithm. (A) Line plot illustrating the relationship between the number of trees and the misclassification rate and out-of-bag (OOB) error in the Random Forest model. (C–E) Variable selection in the least absolute shrinkage and selection operator (LASSO) regression model. (C) The variable selection process during LASSO regression, with the horizontal axis representing the penalized parameter lambda (log-transformed) and the vertical axis showing the coefficients of each variable. (D) The 10-fold cross-validation (CV) of the LASSO model. The blue line represents the value of lambda and the corresponding variable number with non-zero coefficients selected by lambda.1se, while the red line represents the value of lambda and the corresponding variable number with non-zero coefficients selected by lambda.min. (E) Bar plot displaying the coefficients of the LMRGs identified by LASSO regression. (F) The importance score of the top 10 variables identified by the XGBoost model. (G) Venn plot illustrating the common LMRGs identified by the three machine learning algorithms. (H–I) Facet boxplots (H) and receiver operator characteristics (ROC) curves (I) to demonstrate the expression pattern and diagnostic ability of key LMRGs in periodontitis. (J–K) Boxplots (J) and ROC curve (K) showing the expression pattern and diagnostic ability of the LMRGs score in periodontitis.

    Subsequently, ROC curves were used to evaluate the diagnostic ability of these LMRGs in distinguishing between periodontitis and healthy participants. The results demonstrated that these genes performed well in differentiating periodontitis from healthy individuals (Fig. 2I). The AUC value for CWH43 was 0.898 (0.848 − 0.947), followed by OSBPL6 (0.894 [0.849 − 0.939]), CLN8 (0.864 [0.810 − 0.918]), ADGRF5 (0.855 [0.808 − 0.903]), and FABP4 (0.850 [0.794 − 0.906]) (Fig. 2I). To further enhance the diagnostic ability of these genes for periodontitis, we developed an LMRGs score using the following formula: LMRGs score = 1.137 * FABP4 + (-1.113) * CWH43 + (-1.701) * CLN8 + 2.403 * ADGRF5 + (-1.642) * OSBPL6. As expected, periodontitis patients had higher LMRGs scores than healthy individuals (Fig. 2J). Integrating these genes into one index further improved the diagnostic ability, with the LMRGs score yielding an excellent discrimination ability between periodontitis and healthy samples, with an AUC of 0.954 (0.919 − 0.988) (Fig. 2K). We also validated the expression levels and diagnostic ability of the identified hub LMRGs and LMRGs score in an external validation cohort, with consistent results observed (Figure S1A-D). Ultimately, we also validated the protein expression level of these hub genes in healthy and periodontitis human samples through IHC staining. The results indicated that CLN8, CWH43, and OSBPL6 were upregulated in periodontitis tissues, while ADGRF5 and FABP4 were upregulated in healthy tissues (Figure S2). Taken together, these results indicate that these LMRGs and their integrated index, the LMRGs score, have promising diagnostic ability for periodontitis.

    Immune cell infiltration landscape and immune function status in patients with periodontitis

    Next, we investigated immune cell infiltration and immune function in periodontitis using ImmuCellAI and GSVA. In the GSE16134 cohort, we observed multiple immune cells, including CD4 + T cells, Th17, follicular helper T cell (Tfh), nTreg, CD4 naive T cells, iTreg, Th1, Th2, dendritic cells (DC), exhausted T cells, and CD8+ T cells (Fig. 3A). Consistent results were observed in the GSE10334 cohort (Fig. 3D). We then examined the association between LMRG scores and the infiltration levels of different immune cells in periodontitis and healthy tissues. A significant positive correlation was found between LMRG scores and the infiltration of CD4+ T cells, CD4 naive T cells, nTreg, Th1, Th17, Tfh, and exhausted T cells in periodontitis tissues in the GSE16134 dataset (Fig. 3B). In contrast, LMRG scores were significantly negatively correlated with the infiltration of macrophages and cytotoxic T cells (Fig. 3B). Similar correlation patterns were identified in healthy participants in the GSE16134 dataset (Fig. 3C) and all participants in the GSE10334 dataset (Fig. 3E, F). Boxplots demonstrated that periodontitis tissues had significantly higher infiltration levels of CD4+ T cells, Tfh, and Th17 than healthy tissues in both the GSE16134 and GSE10334 datasets (Fig. 3G, H). However, the infiltration levels of gamma delta T cells and macrophages in periodontitis were significantly decreased compared to healthy individuals (Fig. 3G, H).

    Fig. 3
    figure 3

    Immune cell infiltration and immune function estimation in periodontitis. (A–C) Hierarchical clustering heatmap (A) and correlation heatmap (B–C) illustrating the diverse immune cell infiltration status and their correlation with lipid metabolism-related genes (LMRGs) in periodontitis and healthy individuals in the GSE16134 cohort. (D–F) Hierarchical clustering heatmap (D) and correlation heatmap (E–F) illustrating the diverse immune cell infiltration status and their correlation with LMRGs in periodontitis and healthy individuals in the GSE10334 cohort. (G–H) Boxplots demonstrating the differences in immune cell infiltration estimated by ImmuneCellAI between periodontitis and healthy individuals in the GSE16134 (G) and GSE10334 (H) datasets. (I) Significant altered biological processes in periodontitis identified by Gene Set Enrichment Analysis (GSEA). ns no significance; * P-value < 0.05; ** P-value < 0.01; *** P-value < 0.0001.

    GSVA was performed to investigate immune function in periodontitis. The results indicated that antigen presentation processes were significantly activated in periodontitis, as evidenced by increased scores for APC co-stimulation, HLA, and aDCs (Figures SA, B). This further triggered T cell activation and inflammation responses in periodontitis, as indicated by the increased scores of multiple T cell subsets and the inflammation-promoting score in GSVA (Figure S3A, B). GSEA was then employed to investigate significantly altered biological processes and pathways between periodontitis and healthy participants. Consistent with the GSVA analysis, multiple immune-related processes and inflammation response-related pathways were significantly activated in periodontitis, as evidenced by the activation of inflammatory response, TNF-α signaling via NF-κB, IL2-STAT5 signaling, IL6-JAK-STAT3 signaling, and chemokine signaling pathways (Fig. 3I and Figure S4A). Furthermore, epithelial-mesenchymal transition (EMT), angiogenesis, apoptosis, and metabolism pathways were also significantly activated in periodontitis (Fig. 3I and Figure S4A). Collectively, these results revealed that the immune microenvironment plays pivotal roles in periodontitis.

    scRNA-seq analysis identifies cell subtypes and cell communication in periodontitis

    Considering the limitations of bulk RNA-seq data in reflecting the immune microenvironment components in patients, we performed scRNA-seq analysis to decipher the immune microenvironment of periodontitis at single-cell resolution. After quality control and dimensionality reduction, we identified 12 distinct clusters in both periodontitis and healthy gingival tissue (Fig. 4A and Figure S4B). The top five marker genes of each cluster were visualized using bubble plots (Fig. 4B) and heatmaps (Figure S4C). Ultimately, using the SingleR algorithm, we identified eight main cell types among the 12 clusters: plasma cells, monocytes, multipotent progenitor cells (MPP), fibroblasts, keratinocytes, CD8+ effector memory T cells (Tem), microvascular (mv) endothelial cells, and class-switched memory B cells (Fig. 4C). We then validated the expression levels of key LMRGs at the single-cell level. Our analysis revealed that ADGRF5 and FABP4 were primarily expressed in fibroblasts and microvascular endothelial cells, while CLN8 was expressed across all single-cell types. In contrast, OSBPL6 was not expressed in CD8+ Tem cells, plasma cells, or monocytes (Fig. 4D and Figure S5A-C). Subsequently, we mapped the cell communication network among these cell types, identifying strong interactions mediated by multiple signaling pathways, including MHC-II signaling, CXCL signaling, and ADGRE5 signaling (Fig. 4E). These pathways are crucial in antigen processing and the inflammatory response. Further investigation of these pathways revealed that HLA and CD4 primarily contributed to signaling from various cells to MPP (Figure S6A), CXCL12 and CXCR4 contributed to signaling from plasma cells to other cells (Figure S6B), and ADGRE5 and CD55 contributed to signaling from diverse cells (Figure S6C).

    Fig. 4
    figure 4

    Single-cell RNA sequencing analysis in periodontitis to decipher its immune microenvironment landscape. (A) The utilization of the t-distributed stochastic neighbor embedding (tsne) algorithm identified 12 clusters in gingival tissues from individuals with periodontitis and healthy individuals. (B) Dot plot visualization of the top five marker genes for each cluster. (C) Annotation of eight cell types in gingival tissues from individuals with periodontitis and healthy individuals. (D) Feature plots displaying the expression levels of hub lipid metabolism-related genes (LMRGs) across the cell subtypes. (E) Cell communication network and the contribution of MHC-II, CXCL, and ADGRE5 signaling among different cell types. (F) Ridge plots displaying the indicated biological pathway scores estimated by single-cell Gene Set Enrichment Analysis (GSEA) among different cell types.

    Single-cell GSEA was performed to investigate the most relevant biological functions of different cell subtypes in periodontitis. The results suggested that monocytes and MPPs primarily contributed to the inflammatory response and immune reaction in periodontitis by activating pathways such as the inflammatory response, TNF-α signaling via NF-κB, IL6-JAK-STAT3 signaling, IL2-STAT5 signaling, complement, and reactive oxygen species pathways (Figure S6D). Fibroblasts were mainly involved in processes like EMT, myogenesis, and Wnt/β-catenin signaling (Figure S6D). Keratinocytes and mv endothelial cells were engaged in cell proliferation by activating the E2F targets, MYC targets V1, and MYC targets V2 pathways (Figure S6D). We further performed single-cell GSEA to investigate the significantly altered biological processes of these cell types in periodontitis. Consistent with previous findings, the results indicated that the IL6-JAK-STAT3 signaling, inflammatory response pathway, TNF-α signaling via NF-κB, and interferon gamma response pathways were significantly activated in monocytes (Fig. 4F and Figure S6D). Meanwhile, EMT was exclusively activated in fibroblasts. The process of adipogenesis was activated in multiple cell types in periodontitis, except for CD8+ Tem and class-switched memory B cells (Fig. 4F and Figure S6D). Taken together, these findings highlight the important role of monocytes in periodontitis through the activation of inflammatory response pathways.

    Deciphering the heterogeneity among different monocytes clusters in periodontitis

    Given the important role and heterogeneity of monocytes in periodontitis, we further investigated the role of different subsets of monocytes by clustering them into distinct groups. Using the t-SNE algorithm, we identified five monocyte clusters, with the top five marker genes for each cluster summarized in Fig. 5A. Based on the unique expression patterns of these marker genes (Figure S7), we annotated the monocyte clusters as follows: C1 (APOE+SELENOP+ monocytes), C2 (CD1E+ monocytes), C3 (GZMB+PTGDS+ monocytes), C4 (CLEC9A+ monocytes), and C5 (IGHA1+ monocytes) (Fig. 5B). Trajectory analysis revealed three differentiation states among these monocyte subtypes. C1 represented the earliest stage of differentiation, while C4 appeared at the terminal stage (Fig. 5C). Additionally, BEAM analysis was conducted to investigate differentially expressed genes (DEGs) before and after branch point 1. We identified the top 100 DEGs, categorizing them into three subtypes as shown in Fig. 5D.

    Fig. 5
    figure 5

    Deciphering the heterogeneity of monocytes in periodontitis through single-cell analysis. (A) Dot plot visualization of the top five marker genes for each monocyte cluster. (B) Annotation of five monocyte subtypes based on their unique marker genes. (C) Cell trajectory and pseudotime analysis among monocyte subtypes. (D) Differentially expressed genes (DEGs) of branch 1 along the pseudotime were hierarchically clustered into three subclusters, and their biological functions were estimated by Gene Ontology (GO) enrichment analysis. (E) Hierarchical clustering heatmap showcasing the activity of diverse biological processes among different monocyte subtypes.

    GO enrichment analysis demonstrated that DEGs in cluster 1 were mainly involved in neutrophil activation, inflammatory response, and immune response. DEGs in cluster 2 were primarily associated with signal peptide processing, while DEGs in cluster 3 were linked to antigen presentation and T cell-mediated cytotoxicity (Fig. 5D). We further performed GSVA to explore the significantly altered biological processes in these monocyte subtypes. As illustrated in Fig. 5E, clusters C1 and C2 were predominantly involved in immune and inflammatory response pathways (Fig. 5E). Additionally, the EMT process was activated in C1 and C2 monocytes (Fig. 5E). In contrast, cell proliferation, adipogenesis, fatty acid metabolism, and oxidative phosphorylation were activated in C3, C4, and C5 monocytes (Fig. 5E). Single-cell GSEA was conducted to validate these findings, with consistent results observed (Figure S8). Taken together, different monocyte subtypes have distinct roles in periodontitis.

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  • Factoring the Cost of Carbon into Long-Term Decision-Making

    Factoring the Cost of Carbon into Long-Term Decision-Making

    INTRODUCTION

    Decarbonization is a major investment theme for long-term investors, given the worldwide shift already under way in energy infrastructure, transportation, agriculture, business models, and the built environment. Annual climate finance surpassed $1 trillion in 2021 and has been climbing since. Renewable energy generation will meet 35 percent of global demand by 2025; that mix was just 19.5 percent in 2010. Investment flows contrast with the global cost of climate change damages, which could range between $1.7 trillion and $3.1 trillion per year by 2050.

    Climate-related risks will have far reaching implications for the long-term investment portfolios of sovereign wealth funds, pension funds, insurance companies, and endowments. A recent survey of 200 asset owners found that 56 percent plan to increase climate investment over the next 1-3 years, and 46 percent said that navigating the transition is their most important investment priority over the same period.

    Despite momentum, progress feels incremental. Today’s volatile political and geopolitical context has upended climate and industrial policy, creating significant uncertainty for long-term investors. A reshuffling of global trade and supply chains also means a reshuffling of where emissions occur. To be clear, the climate transition was never assumed to progress in a linear fashion. At times, decarbonization pathways may appear to stagnate or even move in the wrong direction. While various regions are at different points in implementing climate policies, greater policy uncertainty has the effect of widening potential outcomes.

    Investors are probably wondering, where do we go from here?

    Successful long-term investing is built around having a future view of risks and opportunities, including how climate policy and regulations will affect future investment, and in particular, how economies move to price carbon emissions. This paper will provide a fresh look at how asset owners can approach risks and opportunities in the climate transition, by focusing on carbon price risk and how the cost of carbon could affect portfolios over the long run. The end of this chapter contains toolkits for asset owners and investors to facilitate analysis of transition risk in portfolios.

    Straight talk on climate risks and opportunities

    Imagine a market where the trajectory is unclear. It’s changing rapidly, and the instruments and rules are new and different. There may be disparate prices in different jurisdictions for the same instrument, while opportunities for making money seem overlooked. Is it high yield bonds or mortgage-backed securities in the 1980s? Hedge funds or emerging markets in the 1990s?

    Carbon markets today evoke that feeling – they’re nascent and perhaps even inefficient. They possess the ingredients that attract market participants and support the search for alpha, through unique insights, due diligence, and data analysis.

    Carbon markets and the cost of emissions within them are not a requirement or a commitment made by investors, but rather present as a financial input in computing future risk and return opportunities. Just as interest rates, inflation, growth, and other key macro-economic factors serve as building blocks for evaluating asset allocation, real estate deals, infrastructure and private equity, the cost of carbon can also serve as an input in the investment process. Specifically, a view on where carbon markets and policy are going, and how that could affect cash flows of investments over various time horizons.

    The entire investment industry is built around having a future view on macro-economic factors, yet there seems to be a prevailing thought in financial markets that the cost of emissions is far off in the future. But the future can sneak up on you, and no investor likes to be caught off guard. Investors may be happy collecting interest and dividends now, but if they’re unprepared, portfolios will not be resilient to shocks in carbon markets.

    Asset owners are in a unique position

    Asset owners that are ahead of the curve assess the cost of carbon as a financial input for transition plans, strategy, and risk assessment, regardless of their location, political views, or whether there is a net-zero commitment or not. Asset owners are at the center of a “value chain” of investment activity: they invest in companies and assets directly that generate emissions or hire external asset managers to invest on their behalf.

    Asset owners are currently navigating a period where parts of their portfolios may reflect the economics of carbon emissions, while others may not. In Decarbonizing Long-term Portfolios, FCLTGlobal research found that an adaptable, top-down approach to decarbonization provides long-term investors with multiple levers for addressing climate risk inside their investment portfolios while fulfilling their purpose and capitalizing on new opportunities.

    The companies that asset owners invest in may or may not use internal carbon prices (ICPs) or shadow carbon pricing to reflect the cost of emissions over time, or they may be subject to regulated carbon prices. A recent FCLTGlobal study found that 14 percent of MSCI ACWI companies reported using an internal carbon price. This was up from just 5 percent five years ago.

    The asset managers that asset owners hire serve as a bridge between portfolio companies and owners, on issues like strategy, company engagement, investment selection, and due diligence. Effective investment mandate design holds managers accountable to the owner’s expectations and views on climate change. Institutional Investment Mandates: Anchors for Long-Term Performance provides tools for asset owners and managers to create mandates that align both parties on long-term goals, including sample mandate terms that consider climate objectives.

    Investors face a patchwork of global policy and regulations

    Today, the world is at different points on internalizing the economics of emissions. One study places the global average price of carbon at around $23 a ton in 2023, while it is estimated that just 24 percent of global emissions are covered by direct or indirect pricing measures. Analysis from the World Bank Group includes measures such as direct carbon taxes, fuel taxes, and emissions trading schemes (ETS), net of fuel subsidies (exhibit 1). The majority of emissions pricing has been through fuel taxes, with ETS a small but growing portion.

    Policy sets the backdrop to climate action, yet regulatory treatment of carbon emissions is uneven around the world. Furthermore, carbon markets exist as mandatory (compliance) schemes as well as voluntary programs. Economists debate the merits of implementing quantity-based instruments (ETS), or price-based (fuel taxes) policies, without a strong consensus on an optimal approach for adoption in the current context. Green incentives and decarbonization subsidies, like tax credits for clean energy investment, have also been a major factor in shaping markets. As a result, investors face the challenge of investing in markets at various stages of developing their domestic policies for pricing carbon emissions. Are we in the midst of a “carbon carry trade” where capital is drawn to regions where emissions are relatively underpriced compared to regions where the cost of carbon is internalized by markets?

    It is a fast-evolving landscape, with policy taking steps forwards and backwards. Yet momentum has been building in local markets. The global value of traded carbon dioxide (CO2) permits reached a record $948.75 billion in 2023, while 12.5 billion metric tons of carbon permits changed hands. Exhibit 2 shows regions around the world that have implemented various policies to capture the cost of carbon in emissions.

    Even since this graphic was produced in May 2024, major markets have implemented pricing mechanisms. Brazil established the Brazilian Greenhouse Gas Emissions Trading System in November 2024, to be phased in over the next five to six years. Indonesia has been advancing cap-and-trade with plans to expand coverage to industrial sectors.

    Investors are closely following developments in the European Union and its Emissions Trading System, which is set to decrease the quantity of free emissions allowances, leading to potentially higher prices over time. New mechanisms are arising, such as carbon tariffs, which require importers to pay the same carbon prices as domestic producers to reduce “carbon leakage”. The first carbon-tariff system, the EU Carbon Border Adjustment Mechanism (CBAM), takes effect in October 2023 for reporting purposes, and becomes chargeable in January 2026. CBAM has the potential to significantly influence market development as it serves as an incentive for other countries to price emissions. Why would a country let other governments collect revenues that they could be collecting on local production that is exported to the EU?

    Understanding the barriers to evaluating the cost of carbon for portfolios and assets

    FCLTGlobal convened members for a working group in Q4 2024, with asset owners and asset managers sharing their experiences on the theme of climate change and managing transition and physical risks in portfolios. Member CEOs met at FCLTGlobal’s annual Summit in January 2025, where the subject of addressing future climate costs featured in the agenda. CEOs were concerned with carbon pricing realities and how low carbon prices translate into weak investment signals. They also highlighted the benefits of scenario planning based on climate science fundamentals – actual levels of CO2 in the atmosphere and projections going forward. Several things stood out from these discussions, including:

    • Uncertain financial impact – Regulatory uncertainty and the timing of policy development complicate short- and long-term capital allocation decisions. Individual company responses, as well as decarbonization pathways and how emissions cost will affect future earnings also contributes to financial uncertainty. An investor may determine little impact to future earnings, if, for instance, companies can pass through higher costs of carbon to consumers. Pass-through strongly depends on the market structure and the supply-demand equilibrium.
    • Low confidence in financial assumptions – Uncertainty around the trajectory and level of carbon prices leads to lower confidence in risk/ return assumptions. Low confidence in assumptions means that information output from models, scenario analysis, and due diligence does not significantly impact or influence investment decision making. There is no singular quantitative model or approach that fully captures the risk of carbon in portfolios. For analyzing real estate investment like a building, it’s more straightforward. A business, with complex supply chain, shipping routes, and energy sources, is much more complicated.
    • Focus on immediate financial performance – Some investors fall into the trap of prioritizing short-term financial performance. While carbon prices are comparably low in the current environment, assuming they will be low forever could expose portfolios to future shocks.
    • Cost and complexity – While disclosures have been improving, data collection and management as well as the complexity of measuring emissions has been a challenge for investors. Not all companies globally report on their emissions, requiring estimation methods in some instances. Yet you could also say that there is too much data, which makes focusing on what is material and impactful to a business more difficult to process and interpret.

    STAYING AHEAD OF THE CURVE

    The cost of carbon, reflected as a price per ton of emissions, is a critical financial input.

    68 percent of financial professionals in a recent survey believe that climate risk is mispriced in the stock market. Investors clearly grapple with uncertainty about the future path of climate change, the energy transition, policy parameters and adaptation by firms and households. Market pricing is also hampered by a lack of historical data, consistent methodologies, standardized metrics, and comparable disclosures around climate risks.

    There is a real risk of underestimating – or overestimating – the cost of emissions and its impact on asset prices, but that doesn’t mean it should be left out of the formula. Effective processes place less of an emphasis on accurately forecasting future carbon costs, and more on developing fundamental analysis around policy, market development, and company response, with an objective of embedding those views in decision making. Few investors accurately forecast the path for interest rates, yet that doesn’t mean investors shouldn’t develop views on how central banks may set monetary policy.

    Not all emissions are the same

    Measuring portfolio emissions is a daunting task. A number of asset owners and asset managers have developed methodologies to measure their carbon footprints – there are plenty of good practices for investors to follow in this regard. Yet there are gaps in that reporting, in asset classes like private equity where data may not be available, or other blind spots to consider. Ask an investor how confident they are in their assessment of carbon footprint and you may get a caveated answer.

    In developing decarbonization scenarios and cost scenarios, investors could make some simplifying assumptions (Exhibit 3). Considered to be mostly part of Scope 1 or 3, Unabatable emissions are the emissions that are too costly to reduce or eliminate, or there isn’t yet a technological solution to reduce them. These are the emissions that a company ends up paying for, affecting earnings. Scope 2 emissions would eventually be mitigated through the decarbonization of energy systems, with potential cost pass-through. As one investor put it at FCLTSummit 2025, “Would you rather own 1 ton of Scope 1 emissions, 5 tons of Scope 2, or 1 ton of Scope 3. I would take Scope 2 emissions because Scope 1 are hard to abate, the value at risk comes from Scope 1.” The source of emissions really matters: a company or asset with high Scope 1 will be more sensitive to the price of carbon, with an asset valuation as a function of how difficult they are to abate or mitigate.

    Climate winners and losers

    Building on the concept of asset valuation sensitivity to emissions, carbon pricing can be used to uncover which companies or assets are poised to benefit from higher carbon prices, and which will be harmed. Just as one can view that owning shares in an oil company is like being long the price of oil, it’s also tantamount to being short the price of carbon. The higher the price of carbon, the higher the risk to earnings of unmitigated emissions. The same can be said for companies that are “long carbon prices.” Depending on whether the price of carbon reflects a cost, or is a source of revenue, it’s like having a short or long call option on the price of carbon embedded in your portfolio.

    Tesla, which only manufactures electric vehicles, has earned billions of dollars selling emissions credits to other automakers, collecting $2.1 billion in the first nine months of 2024 alone, which was 43 percent of net profit. Carbon credits have been a key revenue driver for the automaker, even as other automakers have struggled to meet regulated emissions targets. A long/short mindset to the price of carbon reinforces the view that the price of carbon is a financial input or indicator in valuing an asset and recognizes that there will be winners and losers as carbon prices fluctuate.

    The market seems to overlook the possibilities of technological developments, especially in the energy sector, which could put downward pressure on carbon prices. Investing in low carbon technologies and research and development holds the potential to deliver winners and reduce carbon risk in portfolios.

    Financial tools in carbon markets are improving

    The investment industry spends significant time and resources developing forward-looking views on key financial variables, the price of carbon is just another to add to that mix. As carbon markets continue to mature, several developments in financial markets have supported investors and companies in managing risks. The emergence of derivatives markets is one such development. Futures and options markets volumes for the EUA, UKA, CCA, and RGGI, the largest cap and trade markets in the world, have been increasing (Exhibit 4).

    Broadly speaking, derivatives aid in the allocation of risks and provide tools for companies and investors to manage risks, and they can lower the cost of diversifying portfolios. It is also a compliance tool for meeting emissions caps placed on regulated entities. Companies can lock-in prices on their future carbon emissions through derivatives markets. Investors can trade derivatives contracts, speculate on prices, search for arbitrage opportunities, or hedge portfolio exposures. Negative carbon convenience yields have attracted the attention of carbon traders interested in exploiting arbitrage opportunities between carbon spot and futures markets. Furthermore, Investors can use price signals from carbon derivatives to assess climate transition risk in their portfolios.

    The forward price curves of futures contracts offer market views on the future price of emissions and is analogous to the term structure of interest rates (Exhibit 5). Although academic research in commodities markets finds that futures prices have not been reliable predictors of subsequent price movements, derivatives markets do provide a complementary source of information for investors to analyze.


    APPROACHES TO INTEGRATE RISKS AND OPPORTUNITIES IN PORTFOLIO INVESTMENT DECISION MAKING

    Given significant uncertainty in climate change policy, geopolitics, technology, and in some cases, backlash against sustainability initiatives, asset owners and long-term investors would benefit from a “reboot” of their approach to managing risks and opportunities resulting from climate change. Despite the near-term uncertainty, investors able to think long-term enough acknowledge the risk that the cost of carbon places on portfolios.

    A recent study combining climate scenario analysis with assessments of impacts on firm revenues and operating costs—capturing both winners and losers—found that aggregate losses on an equity portfolio composed of MSCI World Index companies could range from 0.5 to 6.0 percent. Sector-specific losses were found to be much higher, reaching as much as 10 percent to 60 percent in vulnerable industries such as utilities.

    One firm’s added cost could become another firm’s added revenue. As such, investors need forward-looking measures of transition risk and opportunity, that are flexible enough to apply to multiple scenarios, and that highlight the upside and downside to companies and industries.

    A handful of leading investors have developed tools

    Investors that are ahead of the curve have defined approaches to climate risk and opportunity, integrating tools into investment strategy and decision making. Investors recognize that we are in a period where not all parts of their portfolio reflect the economics of carbon prices. Some leading examples from asset owners include:

    Temasek. Singapore’s currently applies an internal carbon price (ICP) of $65 per tCO2e to embed the cost of carbon in its investment and operating decisions, and to further align its portfolio and business to the company’s net zero target. Review of the ICP is performed every two years, and takes into account carbon price projections by international bodies. Temasek has also developed a proprietary metric called the “carbon spread”, which reflects its ICP modelled as a spread on top of its risk-adjusted cost of capital, acting as a trigger for deeper analysis into the climate transition and decarbonization plans of prospective investee companies.

    GIC, also of Singapore, has published research on carbon markets and investment portfolio analysis. Carbon Earnings-at-risk Scenario Analysis (CESA) is a forward-looking risk measure that estimates the portfolio’s value at risk due to carbon prices. The tool can be incorporated directly into companies’ valuation analyses and is combined with a scenario analysis approach for assessing carbon earnings-at-risk at the total portfolio level, helping to identify specific areas of vulnerabilities within the portfolio for deeper due diligence. GIC finds that carbon price impact varies widely across climate scenarios, ranging from 0 percent to 14 percent for a global equities portfolio tracking the MSCI All Country World Index.

    Norway’s Norges Bank Investment Management (NBIM) estimates net portfolio losses associated with different climate scenarios using MSCI’s Climate Value at Risk (CVaR) model. CVaR is a bottom-up model that approximates the net climate costs of each individual portfolio company, rolling them up to the portfolio level. In broad terms, the loss estimates are the discounted sum of portfolio losses until 2080 associated with climate policy risk, technological opportunities, and physical climate impacts. Based on NBIM’s global equity investments at the end of 2024, the cumulative impact of climate change on the portfolio’s value by 2080 across various scenarios is estimated to result in a reduction ranging from 2 to 10 percent of present value, and 2 to 8 percent when technology opportunities are considered.

    Striking the right balance

    This report highlights several approaches, in the following toolkits, that enable asset owners and investors to “reboot” their assessments of climate risks and opportunities. During working groups, we heard from participants that striking the right balance between complexity and simplicity of tools was important. Complex methodologies benefit from additional rigor, yet it’s not necessarily precision that is required, but better guidance. Complex tools can be more costly to research and populate and can also be more difficult for investment committees and boards to interpret. Simpler methodologies are easier to accomplish and are less resource intensive and can be easier for investment decision makers to interpret. Although even simple approaches require a certain amount of rigor to support sound decision making.

    CONCLUSION

    The cost of carbon is no longer a hypothetical concern— it is a material financial input that will increasingly shape the investment landscape. As the global climate transition accelerates, asset owners and investors must adapt to a world where carbon pricing is fragmented but gaining traction. Integrating transition risks into financial decision-making, even amid uncertainty, is vital for building resilient portfolios. This involves not only recognizing which companies and sectors are most exposed to emissions costs but also identifying those poised to benefit from the shift to a low-carbon economy. Tools such as carbon beta, NoCEBITDA, and scenario-based valuation adjustments provide practical entry points for making climate risk analysis more actionable and investment-relevant.

    Ultimately, the climate transition is not just a risk to manage, but an opportunity to seize. Investors ahead of the curve are rethinking valuation methods, developing forward-looking tools, and embedding carbon cost assumptions into strategic investment decision making. By reframing carbon as a dynamic financial variable— similar to interest rates or inflation—long-term investors can better navigate an uncertain policy environment and uncover opportunities in a rapidly evolving world.


    TOOLKIT: INDICATORS FOR SCENARIO ANALYSIS

    This toolkit focuses on indicators that align with already established investment methodologies and concepts, essentially building on the “finance language” and expertise that committees and boards already possess, while applying it to climate concepts. These indicators are based on readily available data and disclosures and can complement climate scenario analysis using different assumptions on carbon price levels.

    Market-implied cost of hedging carbon price exposure: Similar to insurance for physical climate exposure, this indicator asks what the cost is to insure against transition risks for asset classes and individual assets with exposure to carbon price risk. The estimated cost to hedge carbon exposure can be used as a “haircut” to prospective returns, in order to map transition risks in equity industries and investments in private equity and real assets. The implied cost to hedge risks can be computed for an individual company, or at the sector/aggregate level, using underlying assumptions of unabated emissions, or emissions exposed to price risk. One study has found that the cost of hedging tail risks using options, on average, amounts to 2 percent of portfolio assets per year.

    NoCEBITDA – Net of Carbon Earnings Before Interest, Taxes, Depreciation, and Amortization: Carbon price risk can leave exposure to fluctuating costs, leading to volatile earnings. Estimations can also include sources of “green revenues” where companies are poised to benefit from higher carbon prices. Carbon adjusted EBITDA over multiple periods forms the basis of valuation models, which makes this tool well suited to analyze private equity, real estate, and infrastructure deals.

    Carbon-adjusted financial indicators, EPS, ROI, IRR: Adjusting EBITDA for carbon-related costs and changes in revenue can serve as a basis for calculating other financial indicators, notably earnings per share (EPS), return on investment (ROI), and internal rates of return (IRR) with applications in both public and private markets.

    TOOLKIT: CARBON BETA

    Carbon beta is a tool designed to measure transition risk in individual stocks and portfolios of stocks. It is a forward-looking measure that determines the extent to which an asset’s price correlates with a carbon risk factor.

    The beta of a stock is a traditional finance indicator of risk with a long academic history, and is a concept well understood in the finance world. It simply measures how the value of a stock or portfolio of stocks moves in relation to the market. For the purpose of computing carbon beta, the “market” is redefined as a group of high emitting stocks believed to possess high climate risk and face potential high costs for abating emissions. The carbon beta of an individual stock or portfolio is its valuation in relationship to the carbon risk portfolio. Huij et al. developed a methodology to estimate asset-level climate risk exposure by regressing stock returns on a pollutive-minus-clean portfolio. The authors find that, not surprisingly, climate risk is highest in energy and utility sectors, and lowest in healthcare and financials.

    The methodology is relatively simple and straightforward, and investors can readily replicate it using existing historical market data and emissions and transition risk disclosures. Investors can even develop their own methodologies on how climate risk is defined in the “market” portfolio. For example, the pollutive-minus-clean portfolio assumes that all emissions are the same, while investors might assign greater weight to some emissions over others. For firms whose emissions occur in the production of goods that reduce emissions elsewhere (e.g. solar panels), or that operate in sectors for which abatement is expected to be easier, investors might perceive lower risk exposures. Interestingly, Huij et al. find that returns to stocks with high carbon betas are lower during months in which climate change is more frequently discussed in the news, during months in which temperatures are abnormally high, and during exceptionally dry months.

    Carbon beta can also be a tool to identify firms that are investing in green technologies. Green innovation is largely driven by firms in the energy sector, yet paradoxically these firms are generally amongst the worst performers on environmental issues. Using green patents as an indicator, Huij et al. test the association of carbon beta with green innovation and find that green innovators are less exposed to climate risk, including firms in the energy sector.

    Carbon beta is but one factor to analyze amongst many. It is an indicator that can be used in concert with other factors while recognizing how factors can interact.


    INTRODUCTION – WHY CLIMATE EXTERNALITIES CAN’T BE IGNORED

    Despite the policy uncertainty and differences around the world, understanding climate-related risks and opportunities is essential to effective long-term capital allocation. Just as interest rates, inflation, and geopolitical risks shape investment decisions, so too do emissions costs, insurance premiums, and the growing financial toll of climate change., ,

    The effects of climate have slowly manifested not only in transition risk (e.g. a grey premium for carbon-intensive sectors like oil and gas), but also in physical risk (e.g. depressed exit-multiples among real estate developments in climate-affected areas)., While some companies still view such risks as immaterial to their strategy, over a long-enough horizon, these previously insignificant costs, are set to hit the bottom line at an ever-consequential rate.

    Climate externalities are the unpriced costs or benefits of business activities that impact the climate system, such as greenhouse gas emissions, water usage, or land degradation.

    These externalities vary by sector and jurisdiction but are increasingly prevalent worldwide. While some companies may currently view these risks as immaterial or choose to wait for regulatory developments, proactively addressing them (through, e.g. pricing carbon internally, hedging future climate risk, and scenario planning) can help manage uncertainty and enhance competitive positioning. Incorporating climate externalities into capital allocation decisions today—before they are fully reflected in regulations or markets—can enable companies to manage risks, seize opportunities, and build long-term resilience.

    While carbon emissions are among the most common and financially significant externalities, especially in emissions-intensive sectors, companies with inherently low carbon footprints—like those in software or professional services—may find other externalities more material. For instance, data centers operated by tech firms often consume substantial amounts of water for cooling purposes, which can strain local water resources, particularly in drought-prone regions.

    Many of these climate externalities ultimately are internalized and show up in the economics of a project, whether through costs, pricing dynamics, or asset values. Whatever assumptions companies make about them will inevitably reshape the risk-return profile of their investments.

    As such, identifying which climate externalities are material—when and where—and determining appropriate responses is a vital tool in helping companies stay ahead of the curve. By factoring future climate-related costs into investment decisions, companies can maximize long-term value.

    In practice, the path to do so is complex. While some firms actively embed climate considerations into their capital allocation decisions, many still struggle to weigh long-term climate risks against short-term financial pressures—particularly when the costs of carbon remain uncertain or inconsistently applied.

    Exhibit 6 (page 20) illustrates how emissions pricing might alter investment attractiveness between two hypothetical projects: when weighing two projects (A and B), their attractiveness to the company varies depending on whether the analysis factors in the future cost of carbon.

    If emissions are priced for the long-term project A may make more sense over project B, and vice versa if emissions are free. In truth, many payoffs to these investments follow a “j-curve”: companies are faced with the decision to “pay now or pay later” when it comes to climate (and carbon especially).

    This challenge is amplified by the fact that many of the tools and signals needed to inform long-term climate-adjusted decisions—such as internal carbon pricing, external regulatory coverage, and credible forward commitments—remain challenging to adopt or apply.

    While still early days, a few key data points illustrate how this plays out across company practice, market coverage, and credibility:

    1. 18% of MSCI ACWI companies reported using an internal carbon price as of 2024. Among those that do, the median price is $49 per ton.
    2. 24% of global carbon emissions are currently covered by an emissions trading system (ETS) or carbon tax —up from 13% in 2014.
    3. 26% of S&P Global BMI companies generated unpriced environmental costs that exceeded their net income—suggesting that externalities remain financially invisible in many corporate accounts.

    Evidence suggests that leading firms are increasingly developing internal views on climate externalities— particularly carbon—and are actively incorporating them into investment and strategy decisions.

    However, many others do not quantify or operationalize these externalities in capital allocation, especially in a time when carbon prices are uncertain, or policies are evolving. Deferring action altogether, adopting a “waitand-see” approach will lead companies to be behind the curve.

    GETTING AHEAD OF THE CURVE IS EASIER SAID THAN DONE

    Amid mounting short-term performance pressures and unclear financial payoffs, few companies meaningfully integrate climate considerations like carbon pricing into capital allocation decisions. , , ,

    For the past 12 months, companies have been scaling back sustainability pledges, as many over-promised and under-delivered. Companies have been called out for “greenwashing” and underperformance.

    Treating climate as a financial issue requires overcoming several key challenges that need to be overcome, as seen in the table below:

    In such a challenging current environment, how can companies perform sufficiently now while keeping an eye toward the future, and what can investors do to support companies in their journeys, while fulfilling their mandates and fiduciary duty?

    TURNING CLIMATE INSIGHTS INTO ACTION

    As companies weigh near-term pressures against long-term climate strategy, many are seeking clearer direction—not in theory, but in practice. They want to know: Who is doing this well? What frameworks are working? And how can we make sound decisions amid evolving regulations and stakeholder expectations?

    In our discussions with corporate and investor leaders, the message is consistent. Organizations are not just looking for metrics—they are looking for clarity. Clarity about how others are embedding climate into real capital allocation decisions. Clarity around how to navigate uncertainty across jurisdictions. And clarity about how to act decisively, without getting ahead of their boards or behind their peers.

    The toolkits on the following pages aim to meet that demand. By showcasing leading company examples and practical tools—ranging from internal carbon pricing and marginal abatement cost curves to climate-adjusted financial metrics—we provide a set of forward-looking approaches for navigating uncertainty, aligning decisions with long-term value, and staying ahead of the curve.

    CONCLUSION

    To get ahead of the curve on climate, forward-thinking companies are integrating climate externalities into overall strategy and capital allocation.

    Internalizing climate externalities like carbon is not a one-time fix—it requires ongoing recalibration of strategy, risk management, and investor communication. Organizations that begin now—by applying internal carbon pricing, stress-testing projects against future scenarios, and translating climate metrics into familiar financial language—will be better positioned to capture upside and avoid downside in a decarbonizing economy.

    The future will reward those who align capital with long-term value creation. Getting ahead of the curve today means thriving in the economy of tomorrow.

    Link to the full report can be found here. 


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    6 World Bank Group, “State and Trends of Carbon Pricing”, 21 May 2024. Link. (go back)

    7 Roncalli, Thierry, and Raphaël Semet, “The Economic Cost of the Carbon Tax”, Amundi Investment Institute, Working Paper 156, March 2024. Link. (go back)

    8 Twidale, Susanna, “Global Carbon Markets Value Hit Record $949 Billion Last Year – LSEG”, Reuters, 12 February 2024. Link. (go back)

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    11 Roncalli, Thierry, and Raphaël Semet, “The Economic Cost of the Carbon Tax”, Amundi Investment Institute, Working Paper 156, March 2024. Link. (go back)

    12 Bauer, Rob, Katrin Gödker, Paul Smeets, and Florian Zimmermann, “Mental Models in Financial Markets: How Do Experts Reason about the Pricing of Climate Risk?”, IZA Discussion Paper No. 17030, 14 June 2024. Link. (go back)

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    15 Davenport, Coral, and Jack Ewing, “Automakers to Trump: Please Require Us to Sell Electric Vehicles”, New York Times, 21 November, 2024. Link. (go back)

    16 Futures and options contracts are linked to the European Union Allowance (EUA), United Kingdom Allowance (UKA), California Carbon Allowance (CCA), and Regional Greenhouse Gas Initiative (RGGI), collectively covering a majority of the world’s traded carbon allowances and credits. (go back)

    17 Palao, Fernando and Angel Pardo, “The Inconvenience Yield of Carbon Futures”, September 2021. Link. (go back)

    18 International Swaps and Derivatives Association, “Role of Derivatives in Carbon Markets”, September 2021. Link. (go back)

    19 Nixon, Dan and Tom Smith, “What Can the Oil Futures Curve Tell Us about the Outlook for Oil Prices?”, Bank of England, 2012. Link. (go back)

    20 Bouchet, Vincent, Thomas Lorens, and Julien Priol, “Beyond Carbon Price: A Scenario-Based Quantification of Portfolio Financial Loss from Climate Transition Risks”, Scientific Portfolio, January 2025. Link. (go back)

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    26 Huij, Joop, Dries Laurs, Philip Stork, and Remco C.J. Zwinkels, “Carbon Beta: A Market-based Measure of Climate Risk Exposure”, April 2024. Link. (go back)

    27 ibid. (go back)

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    39 “FCLTCompass 2023 Report,” FCLTGlobal, 2023. (go back)

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    49 Goldstein, John and Chex Yu. “Climate Metrics 2.0: Measuring What Matters for Real Economy Climate Progress.” Goldman Sachs Asset Management, 2023. Link. (go back)

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  • Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens | BMC Public Health

    Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens | BMC Public Health

    Design

    A cross-sectional design that follows the STROBE (i.e., Strengthening the Reporting of Observational Studies in Epidemiology) checklist was adopted. Figure 2 is a flowchart of the study design.

    Study setting, participants, and recruitment

    The study setting was Accra, Ghana, and the participants were community-dwelling middle-aged and older adults aged 50 years or older. Multistage sampling was utilised to select the participants. We first classified the neighbourhoods of Accra into four cardinal blocks (i.e., north, south, west, and east) and randomly selected a representative number of neighbourhoods from each block. The participants were selected randomly from all selected neighbourhoods based on three selection criteria: (1) being aged 50 years or older; (2) being a permanent resident of Accra, and (3) availability and willingness to participate in the study. We calculated the minimum sample size necessary with the Daniel Soper’s sample size calculator for structural equation modelling [37, 38] based on standard statistics (i.e., moderate effect size = 0.3; power = 0.8, and α = 0.05). The sample size reached was 823, but we increased this number by 10% to allow for attrition. Thus, the minimum sample size of this study was 905.

    Variables, operationalization, and measures

    WSH, the dependent variable, was measured with a 5-item scale with five descriptive anchors (i.e., 1 – strongly disagree, 2 – disagree, 3 – somewhat agree, 4 – agree, and 5 – strongly agree). This measure was adopted in whole from a previous study [9] and was developed based on our earlier definition of WSH. Some of its items are “Overall, my workplace supports me in living a healthier life” and “Most employees here have healthy habits”. It yielded satisfactory internal consistency in the form of Cronbach’s α ≥ 0.7 (overall α = 0.76; men’s α = 0.74; women’s α = 0.77), which is within the recommended cut-off point [9, 39]. Scores on this tool obtained by summing up its items range from 5 to 25, with larger scores indicating higher WSH.

    Illness avoidance and functioning were measured with sub-scales from a previously validated successful ageing measure [11], associated with five descriptive anchors (i.e., 1 – strongly disagree, 2 – disagree, 3 – somewhat agree, 4 – agree, and 5 – strongly agree), and comprised 4 and 9 items respectively. Illness avoidance, the dependent variable, is a measure of overall health and the avoidance of medication as well as therapy. Some of its items are “I did not use medication or therapy” and “I was healthy enough to move around freely”. Functioning, the mediating variable, is a measure of cognitive functioning and how well one could perform physical and social tasks independently. Some of its items are “I had enough energy for daily life” and “When I tried to recall familiar names or words, it was not difficult for me to do so”. Illness avoidance (overall α = 0.72; men’s α = 0.76; women’s α = 0.81) and functioning [overall α = 0.84; men’s α = 0.87; women’s α = 0.80] produced Cronbach’s α ≥ 0.7. The ranges of scores on illness avoidance and functioning were 4–20 and 9–45 respectively, with larger scores indicating higher illness avoidance and functioning.

    OHL, the moderating variable, was measured with a 12-item standard measure adopted in whole from a previous study [36]. The scale was associated with four descriptive anchors [i.e., 1 – strongly disagree, 2 – disagree, 3 – agree, and 4 – strongly agree] and produced satisfactory Cronbach’s α ≥ 0.7 (overall = 0.75; men’s = 0.82; women’s = 0.74). Its scores range from 12 to 48, with higher scores indicating higher OHL. Appendix 1 shows items used to measure WSH, illness avoidance, functioning, and OHL.

    Eight potential covariates were measured following previous research [7, 34, 40, 41]. Chronic disease status was measured with a single question asking participants to report the number of chronic conditions they had, and the responses were coded into two groups (none – 1, and one of more – 2). Self-reported health was measured with a single question asking the participants to report whether their health was poor or good (poor – 1, and good – 2). Like chronic disease status and self-reported health, sex (men – 1, and women – 2), and marital status (not married – 1, and married – 2) were measured as categorical variables and coded into dummy-type variables. Job tenure, age, education, and income were measured as discrete variables. Job tenure was how long (in years) participants had worked in their current organization whereas age was a measure of chronological age. Education was measured as years of schooling whereas income was measured as the individual’s gross monthly earnings in Ghana cedis.

    Instrumentation

    Data were collected with a self-reported questionnaire comprising three sections. The first section presented a statement of the study’s aim, importance, ethical considerations, and general survey completion instructions. The second section presented measures on WSH, OHL, functioning, and illness avoidance, whereas the final part captured questions on the covariates and personal factors. We avoided or minimised Common Methods Bias (CMB) at the survey design stage by following recommendations in the literature [34, 42, 43] to structure sections and questions in the questionnaire. In this vein, specific instructions for completing each scale and section in the right context were provided. The general instructions provided guided the participants to avoid errors in their completion of the survey. Standard scales with concise and unambiguous items or questions were used. In the second stage, Harman’s one-factor approach, a statistical procedure, was followed to investigate the absence of CMB in the data.

    This technique required the use of an exploratory and confirmatory factor analyses to assess the factor structures of the scales used. With this technique, the absence of CMB in the data is confirmed if two or more factors are produced on each scale, or variances extracted are less than 40% [42, 43]. In the exploratory factor analysis, each scale yielded at least two factors, and each factor accounted for less than 40% of the total variance. WSH produced two factors (factor loadings of items ≥ 0.5; variance explained by factor 1 = 31.12, and variance explained by factor 2 = 23.09). OHL (number of factors extracted = 4), functioning (number of factors extracted = 3), and illness avoidance (number of factors extracted = 2) yielded similar results. Confirmatory factor analysis produced consistent results, signifying the absence of CMB in the data.

    Ethics and data collection

    The study received ethical review and clearance from the ethics review board of the Africa Centre for Epidemiology (no. 005-10-2022-ACE) after the board reviewed the study protocol. All the participants provided written informed consent before participating in the study. We gathered data with three specially trained research assistants who administered questionnaires at designated centres. Some participants could not complete the questionnaire at the centres, so they were allowed to take the questionnaires home and return them over two weeks through a private courier hired by the researchers. Data were gathered over four weeks between July and August 2023. Out of 1501 questionnaires administered, 1015 were analysed, 465 were not returned by the participants, and 21 were discarded because at least 50% of their questions were not answered.

    Statistical analysis

    We utilised SPSS 28 (IBM Inc., New York, USA) to summarise the data and perform exploratory data analysis, including the first sensitivity analyses for the ultimate covariates. Amos 28 was used to test the moderated mediation model. Data were summarised with descriptive statistics [i.e., frequency, and mean], enabling us to identify missing data. Marital status was the only variable with 1% missing data, but we performed the exploratory data analysis with the missing values as they were less than 10% (of the data on marital status) and were randomly distributed [34, 41]. We found no outliers in the data after using box plots to visualize the distribution of the data on all continuous variables. Previous studies [7, 34, 40] were then followed to perform the first sensitivity analysis for the ultimate covariates. We utilised this analysis to ensure that only measured covariates likely to confound the primary relationships were incorporated into the moderated mediation model. After following some standard steps (see Appendix 2), none of the measured covariates qualified as the ultimate covariate.

    Fig. 3

    The statical moderated mediation model fitted. Note: WSH – workplace support for health; OHL – occupational health literacy; e1 and e2 are errors

    Figure 3 shows the statistical moderated mediation model tested with Hayes’ Process Model [44, 45] through structural equation modelling. To create the interaction term (i.e., WSHxOHL), we centred the moderator (i.e., OHL) and multiplied it with WSH in harmony with Haye’s Process Model. The moderated mediation was fitted on the whole sample after computing the basic path coefficients (i.e., a, b, and c; see Fig. 3), Simple Slope (SS), Conditional Indirect Effect (CIE), and Index of Moderated Mediation (i.e., InModMed) using the “user-defined estimands” function in Amos 28. Appendix 3 shows the equations used to estimate the SS and CIE on the whole sample and sub-samples (i.e., men and women). The constant in each equation is the standard deviation of the moderator variable. The InModMed, SS, and CIE were estimated at different levels [i.e., low and high] of the moderator variable. The above parameters and their significance were based on 2000 biased corrected sampling iterations (bootstraps) with a 95% confidence interval.

    In the second sensitivity analysis, the statistical model (see Fig. 3) was fitted for men and women, and the relevant parameters (i.e., direct effects, indirect effects, SS, CIE, and InModMed) were estimated for these samples. A minimum of p < 0.05 was used to detect the statistical significance of the effects. The moderation effect was visualized with figures depicting the effect of WSH on functioning at two levels (i.e., low, and high) of OHL. Multivariate normal distribution of the data was not achieved in fitting the models possibly owing to the relatively large sample used [46], but this violation of the assumption was corrected with our 2000 biased-corrected bootstraps [46].

    Table 1 Summary characteristics on demographic and main variables (n = 1015)
    Table 2 Direct and indirect effects of workplace support for health on illness avoidance

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  • The Time-Sensitive World of Fertility Preservation for Patients With Cancer

    The Time-Sensitive World of Fertility Preservation for Patients With Cancer

    In a world where medical advancements are rapidly extending lifespans, the conversation around quality of life posttreatment is becoming increasingly important. For reproductive-age cancer patients, a critical component of that conversation is fertility preservation. Katherine McDaniel, MD, a reproductive endocrinology and infertility specialist with the University of Southern California and HRC Fertility, shed light on the evolving landscape of this crucial field, emphasizing the urgency, challenges, and hope it offers.

    What Fertility Preservation Entails

    Patient speaking with doctor: ©Mark Adams – stock.adobe.com

    McDaniel explains that fertility preservation is a vital option for patients whose cancer treatments, such as chemotherapy, radiation therapy, or surgery, could impact their reproductive health. The primary focus for women is freezing eggs, which can also be combined with sperm to freeze embryos. For men, the core practice is freezing sperm.

    She noted that while these are the main methods, there are advanced techniques for patients who aren’t candidates for traditional methods. “For instance, prepubertal girls aren’t candidates for egg freezing because they don’t have a mature connection between their brain and their ovaries,” McDaniel said. For these patients, a pioneering technique called ovarian tissue cryopreservation has emerged. “We actually remove a whole ovary, we freeze it, and then transplant it back into the patient when they’re ready to conceive, oftentimes decades down the road.”

    A Shift in Awareness and Urgency

    McDaniel has witnessed a significant change in the landscape of fertility preservation over the past decade, primarily in the form of increased awareness. “I think 10 or 15 years ago, many, many patients simply weren’t counseled on fertility preservation in the setting of their cancer diagnoses,” she said. “Understandably, because their teams wanted to focus on treating their cancer, saving their lives, which, of course, is extremely important.”

    Today, however, she sees a greater understanding within the oncology community, leading to more referrals. A crucial part of this shift is the recognition of the urgency involved. McDaniel emphasized that she wants to see patients as soon as they receive their diagnosis, so they can focus on fertility preservation, “maybe even before their oncology team has a treatment plan.” This early intervention is key to ensuring a patient’s reproductive future isn’t overlooked in the rush to begin life-saving treatment.

    The Barriers and the Hope for Change

    Despite the growing awareness, significant barriers remain, with access to care being a major issue.

    “So many of the treatments that we offer aren’t covered under insurance, so the cost is very prohibitive for a lot of patients,” McDaniel noted. She pointed to the variance in state-level mandates, highlighting the progressive step taken in California with Senate Bill 600, which mandates fertility preservation coverage. However, many states lack such mandates, leaving patients with substantial out-of-pocket costs.

    “That access to care issue is really big and will continue to be an issue over the next few years and decades,” she said.

    Additionally, as the age of cancer diagnoses decreases for certain cancers, a new challenge emerges: approaching young patients with sensitivity. McDaniel acknowledged that talking to teens about their reproductive future, especially those who may have had limited contact with the health care system, requires a delicate touch.

    “It’s definitely something that we all need to remain sensitive to, and perhaps even more sensitive to as we have more and more young patients diagnosed with cancer,” McDaniel said.

    A Call to Action for Oncology Colleagues

    McDaniel has a clear message for her oncology colleagues: “Keeping the ASCO recommendations in mind that all reproductive age patients should be counseled on the impact of the cancer therapies on their fertility.” Her primary piece of advice is to refer patients as soon as possible. “As soon as that diagnosis hits your inbox in a reproductive-age patient, please call us, email us, refer us to your patients,” she said.

    McDaniels highlighted that that fertility preservation treatments are time-sensitive and can be expedited to avoid treatment delays. “We are really sensitive to the expedited nature of treatment. We want to see these patients within 24 hours of them calling our clinics.”

    She also highlighted the swift nature of the process itself, noting that treatment can often begin on the first day and be completed within 2 weeks. “We absolutely do not want to delay treatment in any way, shape, or form,” she affirmed. The message is clear: early, swift collaboration between oncology and reproductive endocrinology is the best path forward for patients facing a cancer diagnosis.

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  • Nvidia and AMD’s ‘special treatment’ shakes up the global chip supply chain

    Nvidia and AMD’s ‘special treatment’ shakes up the global chip supply chain

    Donald Trump’s decision to let Nvidia and AMD export AI processors to China in exchange for a cut of their sales will have repercussions far beyond the U.S.

    The semiconductor supply chain is global, involving a wide array of non-U.S. companies, often based in countries that are U.S. allies. Nvidia’s chips may be designed and sold by a U.S. company, but they’re manufactured by Taiwan’s TSMC, using chipmaking tools from companies like ASML, which is based in the Netherlands, and Japan’s Tokyo Election, and using components from suppliers like South Korea’s SK Hynix.

    The U.S. leaned on these global companies for years to try to limit their engagement with China; these efforts picked up after the passage of the CHIPS Act and the expansion of U.S. chip-export controls in 2022. Washington has also pressured major transshipment hubs, like Singapore and the United Arab Emirates, to more closely monitor chip shipments to ensure that controlled chips don’t make their way to China in violation of U.S. law.

    Within the U.S., discussion of Trump’s Nvidia deal has focused on what it means for China’s government’s and Chinese companies’ ability to get their hands on cutting-edge U.S. technology. But several other countries and companies are likely studying the deal closely to see if they might get an opening to sell to China as well. 

    Trump’s Nvidia deal “tells you that [U.S.] national security is not really the issue, or has never been the issue” with export controls, says Mario Morales, who leads market research firm IDC’s work on semiconductors. Companies and countries will “probably have to revisit what their strategy has been, and in some cases, they’re going to break away from the U.S. administration’s policies.”

    “If Nvidia and AMD are given special treatment because they’ve ‘paid to play’, why shouldn’t other companies be doing the same?” he adds.

    Getting allies on their side

    The Biden administration spent a lot of diplomatic energy to get its allies to agree to limit their semiconductor exports to China. First, Washington said that manufacturers like TSMC and Intel that wanted to tap billions in subsidies could not expand advanced chip production in China. Then, the U.S. pushed for its allies to impose their own sanctions on exports to China. 

    “Export controls and other sanctions efforts are necessarily multilateral, yet are fraught with collective action problems,” says Jennifer Lind, an associate professor at Dartmouth College and international relations expert. “Other countries are often deeply unenthusiastic about telling their firms—which are positioned to bring in a lot of revenue, which they use for future innovation—that they cannot export to Country X or Country Y.”

    This translates to “refusing to participate in export controls or to devoting little or no effort to ensuring that their firms are adhering to the controls,” she says.

     Paul Triolo, a partner at the DGA-Albright Stonebridge Group, points out that “Japanese and Dutch officials during the Biden administration resisted any serious alignment with U.S. controls,” and suggests that U.S allies “will be glad to see a major stepping back from controls.”

    Ongoing trade negotiations between the U.S. and its trading partners could weaken export controls further. 

    Chinese officials may demand a rollback of chip sanctions as part of a grand bargain between Washington and Beijing, similar to how the U.S. agreed to grant export licenses to Nvidia and AMD in exchange for China loosening its controls on rare earth magnets. 

    Japan and South Korea may also bring up the chip controls as part of their own trade negotiations with Trump. 

    ‘Expect continuing diversions’

    A separate issue are controls over the transfer of Nvidia GPUs. The U.S. has leaned on governments like Singapore, Malaysia and the United Arab Emirates to prevent advanced Nvidia processors from making their way to China.

    Scrutiny picked up in the wake of DeepSeek’s surprise AI release earlier this year, amid allegations that the Hangzhou-based startup had trained its powerful models on Nvidia processors that were subject to export controls. (The startup claims that it acquired its processors before export controls came into effect).

    As of now, the two chips allowed to be sold in China–Nvidia’s H20 and AMD’s MI308–are not the most powerful AI chips on the market. The leading-edge processors, like Nvidia’s Blackwell chip, cannot be sold to China. 

    That means chip smuggling will continue to be a concern for the U.S. government. Yet “enforcement will be spotty,” Triolo says. “The Commerce Department lacks resources to track GPUs globally, hence expect continuing diversions of limited amounts of GPUs to China via Thailand, Malaysia, and other jurisdictions.”

    Triolo is, instead, focused on another loophole in the export control regime: Chinese firms accessing AI chips based in overseas data centers. “There is no sign that the Trump Commerce Department is gearing up to try and close this gaping loophole in U.S. efforts to limit Chinese access to advanced compute,” he says. 

    How much will the global supply chain change?

    Not all analysts think we’ll see a complete unraveling of the export control regime.

    “The controls involve a complex multinational coalition that all parties will be hesitant to disrupt, given how uncertain the results will be,” says Chris Miller, author of Chip War: The Fight for the World’s Most Critical Technology. He adds that many of these chipmakers and suppliers don’t have the same political heft as Nvidia, the world’s most valuable company. 

    Yet while these companies may not be as politically savvy as Nvidia, they’re just as important. TSMC, for example, is the only company that can manufacture the newest generation of advanced chips; ASML is the only supplier of the extreme ultraviolet lithography machines used to make the smallest semiconductors. 

    “I don’t believe it’s leverage that the Trump administration will easily give away,” says Ray Wang, a semiconductor researcher at the Futurum Group.

    Introducing the 2025 Fortune Global 500, the definitive ranking of the biggest companies in the world. Explore this year’s list.

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  • YouTube turns to AI to spot children posing as adults in US – Tech

    YouTube turns to AI to spot children posing as adults in US – Tech

    YouTube has started using artificial intelligence (AI) to figure out when users are children pretending to be adults on the popular video-sharing platform amid pressure to protect minors from sensitive content.

    The new safeguard is being rolled out in the United States as Google-owned YouTube and social media platforms such as Instagram and TikTok are under scrutiny to shield children from content geared for grown-ups.

    A version of AI referred to as machine learning will be used to estimate the age of users based on a variety of factors, including the kinds of videos watched and account longevity, according to YouTube Youth director of product management, James Beser.

    “This technology will allow us to infer a user’s age and then use that signal, regardless of the birthday in the account, to deliver our age-appropriate product experiences and protections,” Beser said.

    “We’ve used this approach in other markets for some time, where it is working well.”

    The age-estimation model enhances technology already in place to deduce user age, according to YouTube.

    Users will be notified if YouTube believes them to be minors, giving them the option to verify their age with a credit card, selfie, or government ID, according to the tech firm.

    Social media platforms are regularly accused of failing to protect the well-being of children.

    Australia will soon use its landmark social media laws to ban children under 16 from YouTube, a top minister said late last month, stressing a need to shield them from “predatory algorithms”.

    Communications Minister Anika Wells said four-in-ten Australian children had reported viewing harmful content on YouTube, one of the most visited websites in the world.

    Australia announced last year it was drafting laws that will ban children from social media sites such as Facebook, TikTok and Instagram until they turn 16.

    “Our position remains clear: YouTube is a video sharing platform with a library of free, high-quality content, increasingly viewed on TV screens,” the company said in a statement at the time. “It’s not social media.”

    On paper, the ban is one of the strictest in the world. It is due to come into effect on December 10.

    The legislation has been closely monitored by other countries, with many weighing whether to implement similar bans.

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