Category: 3. Business

  • Will Landmark Data Center Deals Reshape Schneider Electric’s (ENXTPA:SU) Digital Infrastructure Narrative?

    Will Landmark Data Center Deals Reshape Schneider Electric’s (ENXTPA:SU) Digital Infrastructure Narrative?

    • At the recent Innovation Summit North America, Schneider Electric revealed multiple high-value collaborations, including a US$1.9 billion supply capacity agreement with Switch, a US$373 million deal with Digital Realty, and a global supply chain decarbonization programme with Marks & Spencer, supporting sectors such as AI data centers, utilities, and retail sustainability.

    • These partnerships highlight Schneider Electric’s central role in driving resilient, scalable energy infrastructure and advancing digital and environmental innovation across several industries worldwide.

    • We’ll consider how Schneider Electric’s landmark data center agreements may strengthen its position within the evolving digital infrastructure market.

    We’ve found 15 US stocks that are forecast to pay a dividend yield of over 6% next year. See the full list for free.

    Schneider Electric investors are buying into a vision centered on accelerating demand for digital infrastructure, electrification, and energy efficiency solutions worldwide. The recent US$1.9 billion and US$373 million data center agreements with Switch and Digital Realty meaningfully reinforce near-term catalysts tied to the AI-driven data center buildout, which remains a key growth engine; however, these deals do not materially reduce exposure to ongoing margin pressure from negative product mix, particularly as heavy investments ramp up to capture future demand.

    Among the latest announcements, the large-scale Supply Capacity Agreement with Switch is particularly relevant, as it demonstrates Schneider Electric’s ability to capture a greater share of the rapidly expanding AI and hyperscale data center market, directly supporting the company’s multi-year growth pipeline in this sector.

    In contrast, investors should be aware of ongoing risks around margin compression, particularly if growth in lower-margin Systems outpaces more profitable Product lines and leads to…

    Read the full narrative on Schneider Electric (it’s free!)

    Schneider Electric’s narrative projects €48.6 billion in revenue and €6.7 billion in earnings by 2028. This requires 7.3% yearly revenue growth and a €2.4 billion increase in earnings from €4.3 billion today.

    Uncover how Schneider Electric’s forecasts yield a €265.10 fair value, a 15% upside to its current price.

    ENXTPA:SU Community Fair Values as at Nov 2025

    Eight Simply Wall St Community fair value estimates for Schneider Electric range from €144.43 to €265.10 per share, highlighting widely differing views. While some participants see strong upside, the company’s exposure to ongoing margin headwinds could be a crucial factor shaping future performance; explore how other investors assess these potential trade-offs.

    Explore 8 other fair value estimates on Schneider Electric – why the stock might be worth as much as 15% more than the current price!

    Disagree with existing narratives? Create your own in under 3 minutes – extraordinary investment returns rarely come from following the herd.

    Our top stock finds are flying under the radar-for now. Get in early:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include SU.PA.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • Gemini 3 gives Google a boost in the AI race against OpenAI and Nvidia

    Gemini 3 gives Google a boost in the AI race against OpenAI and Nvidia

    Google just threw another twist in the fast-changing AI race. And its biggest competitors are taking notice.

    “We’re delighted by Google’s success — they’ve made great advances in AI and we continue to supply to Google,” Nvidia wrote in a November 25 post on X, before adding that “NVIDIA offers greater performance, versatility, and fungibility than ASICs,” (the application-specific integrated circuits) like those made by Google.

    “Congrats to Google on Gemini 3! Looks like a great model,” OpenAI CEO Sam Altman also wrote on X.

    The posts came just days after mounting buzz about Google’s Gemini 3 model — and the Google-made chips that help to power it. Salesforce CEO Marc Benioff wrote on X that he’s not going back to ChatGPT after trying Google’s new model. “The leap is insane — reasoning, speed, images, video… everything is sharper and faster. It feels like the world just changed, again,” he wrote.

    Now Meta is said to be in talks with Google about buying its Tensor chips, according to The Information, coming after Anthropic said in October that it plans to significantly expand its own use of Google’s technology.

    Shares of Google were up nearly 8% last week, while Nvidia’s were down a little over 2%.

    At stake is more than just bragging rights or a few sales contracts. As the tech industry claims AI will reshape the world — including investment portfolios belonging to everyone from billionaires to 401k-holding retirees — what company and what vision comes out on top could affect nearly every American.

    At face value, Nvidia’s post says the company isn’t worried about Google encroaching on its territory. And for good reason — Google’s chips are fundamentally different from Nvidia’s offerings, meaning they aren’t a match-for-match alternative.

    But that OpenAI and Nvidia felt the need to acknowledge Google at all is telling.

    “They’re in the lead for now, let’s call it, until somebody else comes up with the next model,” Angelo Zino, senior vice president and technology lead at CFRA, told CNN.

    Google and Meta did not immediately respond to a request for comment. Nvidia declined to comment.

    Google is hardly an AI underdog. Along with ChatGPT, Gemini is one of the world’s most popular AI chatbots, and Google is one of the few cloud providers large enough to be known as a “hyperscaler,” a term for the handful of tech giants that rent out cloud-based computing resources to other companies on a large scale. Google services like Search and Translate have used AI as far back as the early 2000s.

    Even so, Google was largely caught flat-footed by OpenAI’s ChatGPT when it arrived in 2022. Google management reportedly issued a “code red” in December 2022 following ChatGPT’s seemingly overnight success, according to The New York Times. ChatGPT now has at least 800 million weekly active users, according to its maker, OpenAI, while Google’s Gemini app has 650 million monthly active users.

    But Gemini 3, which debuted on November 18, now sits at the top of benchmark leaderboards for tasks like text generation, image editing, image processing and turning text into images, putting it ahead of rivals like ChatGPT, xAI’s Grok and Anthropic’s Claude in those categories.

    Google said over one million users tried Gemini 3 in its first 24 hours through both the company’s AI coding program and the tools that allow digital services to connect to other apps.

    But people tend to use different AI models for different purposes, says Ben Barringer, the global head of technology research at investment firm Quilter Cheviot. For example, models from xAI and Perplexity are ranked higher than Gemini 3 search performance in benchmark tests.

    “It doesn’t necessarily mean (Google parent) Alphabet is going to be … the end-all when it comes to AI,” said Zino. “They’re just kind of another piece to this AI ecosystem that continues to get bigger.”

    Google began making its Tensor chips long before the recent AI boom. But Nvidia still dominates in AI chips with the company reporting 62% year-over-year sales growth in the October quarter and profits up 65% compared to a year ago.

    That’s largely because Nvidia’s chips are powerful and can be used more broadly. Nvidia and its chief rival, AMD, specialize in chips known as graphics processing units, or GPUs, which can perform vast amounts of complex calculations quickly.

    Google’s Tensor chips are ASICs, or chips that are custom-made for specific purposes.

    Components of a Nvidia Corp. GB3000 GPU on display during Hon Hai Tech Day conference in Taipei, Taiwan, on Friday, Nov. 21, 2025.

    While GPUs and Google’s chips can both be used for training and running AI models, ASICs are usually designed for “narrower workloads” than GPUs are designed for, Jacob Feldgoise, senior data research analyst at Georgetown’s Center for Security and Emerging Technology, told CNN in an email.

    Beyond the differences in the types of chips themselves, Nvidia provides full technology packages to be used in data centers that include not just GPUs, but other critical components like networking chips.

    It also offers a software platform that allows developers to tailor their code so that their apps can make better use of Nvidia’s chips, a key selling point for hooking in long-term customers. Even Google is an Nvidia client.

    “If you look at the magnitude of Nvidia’s offerings, nobody really can touch them,” said Ted Mortonson, technology desk sector strategist at Baird.

    Chips like Google’s won’t replace Nvidia anytime soon. But increased adoption of ASICs, combined with more competition from AMD, could suggest companies are looking to reduce their reliance on Nvidia.

    And Google won’t be the only AI chip competitor, said Barringer of Quilter Cheviot, and it’s doubtful it will achieve Nvidia’s dominance.

    “I think it’s a part of a balance,” he said.

    Continue Reading

  • ‘Untold story’ of Charlie Munger’s last years

    ‘Untold story’ of Charlie Munger’s last years

    Charlie Munger at Berkshire Hathaway’s annual meeting in Los Angeles California. May 1, 2021.

    Gerard Miller

    (This is the Warren Buffett Watch newsletter, news and analysis on all things Warren Buffett and Berkshire Hathaway. You can sign up here to receive it every Friday evening in your inbox.)

    ‘He never stopped learning’

    In an “exclusive” article headlined “The Untold Story of Charlie Munger’s Final Years,” The Wall Street Journal’s Gregory Zuckerman reveals the “Berkshire vice chair was making gutsy investments, forging unlikely friendships and facing new challenges to the end.”

    Munger died two years ago on Nov. 28, 2023, at the age of 99, just a bit over a month shy of his 100th birthday.

    The Journal writes, “Friends and family say Munger’s eventful last period offers lessons for investors—and a blueprint for how to age with grace, equanimity and purpose.”

    It quotes his stepson, Hal Borthwick as saying, “To the day he died, his mind was running. He never stopped learning.”

    He also never stopped looking for new investments, leafing through data on publicly traded companies in green Value Line binders.

    He went against conventional wisdom in 2023 by investing in two companies involved with coal, which he believed would still be needed due to rising demand for energy, despite environmental concerns.

    Borthwick tells The Journal, “He read an article that said coal was down the chute. He said, ‘Horse feathers.’”

    Friends say he had paper gains of more than $50 million on coal miner Consol Energy and Alpha Metallurgical Resources, which provides coal for steel production.

    (Consol completed a merger with Arch Resources early this year to form Core Natural Resources.)

    Coal is excavated.

    Jim Urquhart | Reuters

    Munger also invested in real estate with an unusual partner.

    In 2005, Munger started mentoring a 17-year-old neighbor whose ADHD was contributing to his difficulties in school.

    Avi Mayer, now 37, tells the WSJ“He listened to my problems and talked about life principles and personal values.”

    “I watched him in action and learned from him, and he handed me books once in a while.”

    Later, Munger backed a real estate company Mayer and a childhood friend established that has become one of the largest owners of low-rise “garden” apartments in California with around $3 billion in holdings.

    Munger “remained involved until the end,” helping to negotiate a building purchase that closed days after he died.

    CNBC Special Podcast: Charlie Munger – A Life of Wit and Wisdom

    The Journal says that as Munger grew older, he spent more time with friends, including a regular Tuesday morning country club breakfast with business associates that could go on for hours.

    He became less “cranky and acerbic,” telling the group, “At my age, you make new friends, or you don’t have any friends.”

    And after many years, Munger’s family gave up on trying to keep him on a healthy diet.

    The wife of his grandson reports Munger’s last food delivery was a whole Korean fired chicken, kimchi fried rice, and waffle fries.

    A friend relates that even as Munger joked that he longed to be “86 again,” he remained optimistic about Berkshire’s future.

    “Once it’s built, you don’t need to be Warren and Charlie. What we have is a framework for looking at investments.”

    BUFFETT AROUND THE INTERNET

    Some links may require a subscription:

    HIGHLIGHTS FROM THE ARCHIVE

    Munger: ‘A life properly lived is just learn, learn, learn’ (2017)

    Charlie Munger explains why making mistakes is vital to success.

    AUDIENCE MEMBER: With all due respect, Mr. Buffett, this question is for Mr. Munger. (Laughter)

    In your career of thousands of negotiations and business dealings, could you describe for the crowd which one sticks out in your mind as your favorite or is otherwise noteworthy?

    CHARLIE MUNGER: Well, I don’t think I’ve got a favorite. But the one that probably did us the most good as a learning experience was See’s Candy.

    It’s just the power of the brand, the unending flow of ever-increasing money with no work. (Laughter)

    AUDIENCE MEMBER: Sounds nice. (Laughter)

    CHARLIE MUNGER: It was. And I’m not sure we would have bought the Coca-Cola if we hadn’t bought the See’s.

    I think that a life properly lived is just learn, learn, learn all the time. And I think Berkshire’s gained enormously from these investment decisions by learning through a long, long period.

    Every time you appoint a new person that’s never had big capital allocation experience, it’s like rolling the dice. And I think we’re way better off having done it so long. And —

    But the decisions blend, and the one feature that comes through is the continuous learning. If we had not kept learning, you wouldn’t even be here.

    You’d be alive probably, but not here. (Laughter)

    WARREN BUFFETT: There’s nothing like the pain of being in a lousy business — (laughs) — to make you appreciate a good one.

    CHARLIE MUNGER: Well, there’s nothing like getting into a really good one. That’s a very pleasant experience and it’s a learning experience.

    I have a friend who says, “The first rule of fishing is to fish where the fish are. And the second rule of fishing is to never forget the first rule.” (Laughter)

    And we’ve gotten good at fishing where the fish are.

    BERKSHIRE STOCK WATCH

    BERKSHIRE’S TOP EQUITY HOLDINGS – Nov. 28, 2025

    Berkshire’s top holdings of disclosed publicly traded stocks in the U.S. and Japan, by market value, based on the latest closing prices.

    Holdings are as of September 30, 2025, as reported in Berkshire Hathaway’s 13F filing on November 14, 2025, except for:

    The full list of holdings and current market values is available from CNBC.com’s Berkshire Hathaway Portfolio Tracker.

    QUESTIONS OR COMMENTS

    Please send any questions or comments about the newsletter to me at alex.crippen@nbcuni.com. (Sorry, but we don’t forward questions or comments to Buffett himself.)

    If you aren’t already subscribed to this newsletter, you can sign up here.

    Also, Buffett’s annual letters to shareholders are highly recommended reading. There are collected here on Berkshire’s website.

    — Alex Crippen, Editor, Warren Buffett Watch

    Continue Reading

  • Amazon (AMZN) Stock Gets Boost as AWS Growth Accelerates and AI Demand Surges

    Amazon (AMZN) Stock Gets Boost as AWS Growth Accelerates and AI Demand Surges

    Amazon.com, Inc. (NASDAQ:AMZN) is one of the AI Stocks Making Headlines on Wall Street. On November 25, TD Cowen analyst John Blackledge reiterated a Buy rating on the stock with a $300.00 price target.

    The firm is optimistic on the stock and believes it is well-positioned amid surging AI demand and cloud infrastructure growth. Blackledge noted how Amazon’s AWS revenue accelerated to 20.2% year-over-year growth in the third quarter of 2025, up from 17.5% in the second quarter.

    Amazon.com, Inc. (NASDAQ:AMZN), Logo, Sign, Brand, Symbol, Isolated,

    rvlsoft / Shutterstock.com

    Management also cited a $200B backlog which doesn’t include several unannounced deals from October. The firm also highlighted Amazon’s recent multi-year deal with OpenAI comprising a $38BN commitment for the AI startup to leverage AWS compute “including ‘hundreds of thousands’ of Nvidia GPUs and the potential to scale to ‘tens of millions’ of CPUs for agentic workloads.”

    Moreover, AWS’s Trainium chips business have also reached a multi-billion dollar run rate, growing more than 150% quarter-over-quarter in the third quarter of 2025.

    “Meanwhile, AWS’s Trainium chips business is now at a multibillion-dollar run rate and growing 150%+ q/q in 3Q25. We project AWS will reach $128.1BN in revenue in 2025, up 19.1% y/y, rising to $348.5BN in 2030 (a 22% CAGR). We forecast AWS operating income to rise to $45.9BN in 2025 and $117.8BN in 2030 (21% CAGR).”

    Amazon.com Inc. (AMZN) is an American technology company offering e-commerce, cloud computing, and other services, including digital streaming and artificial intelligence solutions.

    While we acknowledge the potential of AMZN as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

    READ NEXT: 10 AI Stocks in Focus on Wall Street and 10 Hot AI Stocks to Keep on Your Radar

    Disclosure: None.

    Continue Reading

  • Airlines work to fix software glitch on A320 aircraft and some flights are disrupted

    Airlines work to fix software glitch on A320 aircraft and some flights are disrupted

    Airlines around the world reported short-term disruptions heading into the weekend as they fixed software on a widely used commercial aircraft, after an analysis found the computer code may have contributed to a sudden drop in the altitude of a JetBlue plane last month.

    Airbus said Friday that an examination of the JetBlue incident revealed that intense solar radiation may corrupt data critical to the functioning of flight controls on the A320 family of aircraft.

    The FAA joined the European Union Aviation Safety Agency in requiring airlines to address the issue with a new software update. More than 500 U.S.-registered aircraft will be impacted.

    The EU safety agency said it may cause “short-term disruption” to flight schedules. The problem was introduced by a software update to the plane’s onboard computers, according to the agency.

    In Japan, All Nippon Airways, which operates more than 30 planes, canceled 65 domestic flights for Saturday. Additional cancellations on Sunday were possible, it said.

    The software change comes as U.S. passengers were beginning to head home from the Thanksgiving holiday, which is the busiest travel time in the country.

    American Airlines has about 480 planes from the A320 family, of which 209 are affected. The fix should take about two hours for many aircraft and updates should be completed for the overwhelming majority on Friday, the airline said. A handful will be finished Saturday.

    American expected some delays but it said it was focused on limiting cancellations. It said safety would be its overriding priority.

    Air India said on X that its engineers were working on the fix and completed the reset on more 40% of aircraft that need it. There were no cancellations, it said.

    Delta said it expected the issue to affect less than 50 of its A321neo aircraft. United said six planes in its fleet are affected and it expects minor disruptions to a few flights. Hawaiian Airlines said it was unaffected.

    Pope Leo XIV is on his inaugural foreign trip, to Turkey and Lebanon, and is flying along with the papal delegation and press corps aboard an ITA Airways Airbus A320neo charter.

    The Vatican spokesman, Matteo Bruni, said Saturday that ITA was working on the issue. He said the necessary component to update the aircraft was on its way to Istanbul along with the technician to install it. Leo was scheduled to fly from Istanbul, Turkey to Beirut, Lebanon on Sunday afternoon.

    In France, Transport Minister Philippe Tabarot said the situation has stabilized as several software updates had already been installed. He said the impact was limited in the country with an “almost complete return to normal in French airports.”

    In the U.K., disruption also was minimal. British Airways, for example, said only three of its aircraft required the update, while EasyJet indicated there may be changes to its flying schedule as a result of the update, in which case passengers will be informed.

    Germany’s Lufthansa said most software updates were completed during the night and on Saturday morning. No Lufthansa Group Airlines flights are expected to be canceled due to the current situation, but there may be minor delays over the weekend, it said.

    Scandinavia’s SAS said its flights were operating as normal Saturday, after teams worked overnight to install the required software.

    Mike Stengel, a partner with the aerospace industry management consulting firm AeroDynamic Advisory, said the fix could be addressed between flights or on overnight plane checks.

    “Definitely not ideal for this to be happening on a very ubiquitous aircraft on a busy holiday weekend,” Stengel said from Ann Arbor, Michigan. “Although again the silver lining being that it only should take a few hours to update the software.”

    At least 15 JetBlue passengers were injured and taken to the hospital after the Oct. 30 incident on board the flight from Cancun, Mexico, to Newark, New Jersey. The plane was diverted to Tampa, Florida.

    Airbus, which is registered in the Netherlands but has its main headquarters in France, is one of the world’s biggest airplane manufacturers, alongside Boeing.

    The A320 is the primary competitor to Boeing’s 737, Stengel said. Airbus updated its engine in the mid-2010s, and planes in this category are called A320neo, he said.

    The A320 is the world’s bestselling single-aisle aircraft family, according to Airbus’ website.

    ___

    Associated Press writers Mari Yamaguchi in Tokyo, Jennifer Kelleher in Honolulu, Geir Moulson in Berlin, Pan Pylas in London and Nicole Winfield in Istanbul contributed to this report.

    Continue Reading

  • How Do Recent Renewable Investments Impact HF Sinclair’s Soaring 50.6% Stock Price?

    How Do Recent Renewable Investments Impact HF Sinclair’s Soaring 50.6% Stock Price?

    • If you have ever wondered whether HF Sinclair’s current share price reflects the true value of the company, you are not alone. Let’s take a closer look together.

    • The stock is up 50.6% year-to-date and has surged 35.8% over the past twelve months, indicating that investors may be reassessing its future potential or the risks in play.

    • Recently, news of HF Sinclair’s strategic investments in renewable energy have caught the market’s eye, raising questions about how these moves might influence long-term profitability. These updates have come alongside industry-wide shifts in energy demand, providing vital context for understanding share price momentum.

    • Based on our valuation framework, HF Sinclair scores a 1 out of 6 on undervalued metrics, which you can review in detail here. In the next sections, we will break down what this means using several approaches to valuation and introduce a more insightful way to put these numbers into context at the end.

    HF Sinclair scores just 1/6 on our valuation checks. See what other red flags we found in the full valuation breakdown.

    A Discounted Cash Flow (DCF) model estimates a company’s true value by projecting its future free cash flows and discounting them back to today’s value using an appropriate rate. This approach helps investors understand whether the current stock price reflects its real, underlying financial potential.

    For HF Sinclair, the latest reported Free Cash Flow (FCF) stands at $784 million. Analysts estimate that by the end of 2027, annual free cash flow could decline to around $415 million, with further projections extending to 2035 using industry growth assumptions. Over the next decade, forecasts show gradually decreasing free cash flows, with Simply Wall St extrapolating beyond what analysts provide directly.

    According to this DCF model, the estimated intrinsic value of HF Sinclair’s stock is $38.50 per share. However, this value suggests the market price is currently 37.4% above the fair value implied by the model. In other words, the stock appears significantly overvalued based on the cash flow projections.

    Result: OVERVALUED

    Our Discounted Cash Flow (DCF) analysis suggests HF Sinclair may be overvalued by 37.4%. Discover 920 undervalued stocks or create your own screener to find better value opportunities.

    DINO Discounted Cash Flow as at Nov 2025

    Head to the Valuation section of our Company Report for more details on how we arrive at this Fair Value for HF Sinclair.

    The Price-to-Earnings (PE) ratio is a common valuation tool for profitable companies like HF Sinclair because it illustrates how much investors are willing to pay for each dollar of earnings. Choosing the right PE multiple depends on expectations for a company’s growth and the risks associated with its future earnings. Generally, a higher expected growth and lower perceived risk can justify a higher PE ratio.

    Continue Reading

  • America’s chip sanctions backfired: China’s innovation engine is now unstoppable – Medium

    1. America’s chip sanctions backfired: China’s innovation engine is now unstoppable  Medium
    2. Lithography breakthrough: China creates 14nm chip with compact EUV light source  South China Morning Post
    3. Compact ultraviolet light source helps China enhance 14 nm chip yields  Interesting Engineering
    4. China’s New EUV Light Source Sparks Fears of Rapid Semiconductor Dominance  TechJuice

    Continue Reading

  • Real-World Data Shows Vorasidenib Could Address Earlier Treatment Needs in IDH-Mutant Glioma

    Real-World Data Shows Vorasidenib Could Address Earlier Treatment Needs in IDH-Mutant Glioma

    Earlier treatment options, such as vorasidenib (Vorangio), could address unmet needs for patients with slow-growing IDH-mutant gliomas, according to real-world data reported in a poster presented during the 2025 Society for Neuro-Oncology Annual Meeting.

    In the study, vorasidenib treatments demonstrated minimal toxicity for patients with slow-growing IDH-mutant gliomas researchers have reported— with a treatment approved in 2024 by the FDA, possibly helping to address this issue.

    Real-world observation rates and treatment patterns among patients aged 12 years and older with IDH-mutated glioma and their implications for targeted therapy use were reported.

    Researchers reported that 5,894 with IDH-mutant glioma were identified, of whom 3,212, or 54%, had grade 2 tumors and 2,682, or 46%, had grade 3 tumors. The median age at diagnosis was 39 (range 31-50) years.

    After initial surgery, 2,058 patients were on observation, and 3,660 initiated therapies within 90 days. Of the former group, 1,568 remained on observation until the end of the study period in 2022, while 490 received chemotherapy/radiation after an initial period of observation.

    By 90 days after surgery, 70% of patients who were age 40 years or older had initiated therapy, compared with 57% of those aged 12 to 39 years. At 90 days, 43% of patients age 12 to 39 years and 30% of patients age 40 years or older remained on observation, with 34% and approximately 22%, respectively, still on observation after 5 years.

    Additionally, by 90 days following surgery, 47% of patients with a grade 2 glioma and 82% of patients with a grade 3 glioma had initiated therapy, and at 90 days 53% of patients with a grade 2 glioma and 18% with a grade 3 glioma remained on observation, with 43% and 10%, respectively, still on observation after 5 years.

    “Historical management patterns show that a substantial proportion of patients with [IDH]-mutated glioma were managed with observation, suggesting an unmet need for an effective early intervention,” researchers concluded in their poster presentation of the data. “While younger patients (aged 12 to 39 years) and those with World Health Organization (WHO) grade 2 glioma were more likely to undergo observation, a substantial proportion of patients aged [at least] 40 years and those with WHO grade 3 glioma also underwent observation.”

    Researchers further noted that the fact that patients age 40 years and older or those with grade 3 glioma received radiation or chemotherapy, given those treatments’ well-established long-term adverse effects, should highlight the need for less-toxic alternative treatment options.

    Vorasidenib, researchers stated in the poster “offers an early, effective, low-toxicity treatment option across these patient groups.”

    More Information About Vorasidenib

    Vorasidenib was approved the FDA in August 2024 for the treatment of adult and pediatric patients at least 12 years old with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery including biopsy, sub-total resection, or gross total resection. An IDH1 and IDH2 inhibitor, vorasidenib was the first systemic therapy approved by the agency for patients with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation, according to a notice from the FDA.

    Additionally, longer-term results announced earlier this month showed that vorasidenib continued to benefits patients in this population, according to updated phase 3 INDIGO trial data published in The Lancet Oncology.

    At a median follow-up of 20.1 months, patients treated with vorasidenib experienced superior progression-free survival to those who received placebo, with disease progression in 32% of patients who received the drug and 64% of those who did not.

    References

    1. “Real-world observation rates and treatment patterns in IDH-mutated glioma: Implications for targeted therapy use;” Ostrom Q., Bhagnani T., Benedetti J. et al., presented at the 2025 Society for Neuro-Oncology Annual Meeting, Nov. 19 to 23, Honolulu, Hawaii, poster INNV-37.
    2. “Voranigo Approved by FDA For Astrocytoma or Oligodendroglioma,” CURE, Aug. 6, 2024; https://www.curetoday.com/view/voranigo-approved-by-fda-for-astrocytoma-or-oligodendroglioma
    3. “Voranigo Continues to Benefit Patients With Grade 2 IDH-Mutated Glioma,” CURE, Nov. 4, 2025; https://www.curetoday.com/view/voranigo-continues-to-benefit-patients-with-grade-2-idh-mutated-glioma

    Continue Reading

  • America’s chip sanctions backfired: China’s innovation engine is now unstoppable – Medium

    1. America’s chip sanctions backfired: China’s innovation engine is now unstoppable  Medium
    2. Chip Industry Week In Review  Semiconductor Engineering
    3. Compact ultraviolet light source helps China enhance 14 nm chip yields  Interesting Engineering
    4. China’s New EUV Light Source Sparks Fears of Rapid Semiconductor Dominance  TechJuice

    Continue Reading

  • Nvidia (NVDA) Responds to Competition Fears as Meta Explores Google’s TPUs

    Nvidia (NVDA) Responds to Competition Fears as Meta Explores Google’s TPUs

    NVIDIA Corporation (NASDAQ:NVDA) is one of the AI Stocks Making Headlines on Wall Street. On November 25, Bank of America maintained a positive outlook on the stock, along with AMD and Broadcom, despite intensifying competition in the artificial intelligence chip market.

    The reiterated buys follows reports that Meta (META) is considering using Google’s (GOOG) TPUs in addition to its existing Nvidia GPU supply.

    “Late yesterday, media reports indicated the possibility of Google renting out the TPUs to Meta next year, potentially followed by on-premise deployments (with Meta and maybe others) in 2027. Neither company has made any official comments regarding any such transaction, but if true, it can intensify the competitive landscape for Meta’s current GPU suppliers NVDA and AMD.” – Bank of America analyst Vivek Arya.

    A data analyst with a headset, looking intently at the information unfolding on her screen.

    In response, Nvidia issued a statement contending that it is still the leader in the market.

    “NVIDIA is a generation ahead of the industry — it’s the only platform that runs every AI model and does it everywhere computing is done. NVIDIA offers greater performance, versatility, and fungibility than ASICs, which are designed for specific AI frameworks or functions.”

    According to Arya, Nvidia will still likely dominate the market, albeit at a 75% market share from the estimated 85% it currently holds.

    NVIDIA Corporation (NASDAQ:NVDA) specializes in AI-driven solutions, offering platforms for data centers, self-driving cars, robotics, and cloud services.

    While we acknowledge the potential of NVDA as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

    READ NEXT: 10 AI Stocks in Focus on Wall Street and 10 Hot AI Stocks to Keep on Your Radar

    Disclosure: None.

    Continue Reading